Fabio Arturo Iannotti

Institute of Biomolecular Chemistry (ICB)

Dr. Fabio Arturo Iannotti received his master’s degree in Medical Biotechnology at the University Federico II, Italy in 2006. In 2010, Dr. Iannotti graduated with a Ph.D. in Neuroscience. During this time, he discovered the pro-differentiation and protective role of voltage-gated Kv7 K+ channels in skeletal muscle cells. Part of this research was carried out at the University of California-Davis, USA (2009–2010). In 2011, he began his postdoc at the Institute of Biomolecular Chemistry (ICB)/(CNR), initiating pioneering studies on the role of the endocannabinoid system as well as plant-derived cannabinoids in skeletal muscle disorders. In 2012–2013, he was invited as visiting researcher at the University of Reading, UK. In 2014, he became a permanent researcher at the ICB.

1books edited

2chapters authored

Latest work with IntechOpen by Fabio Arturo Iannotti

Skeletal muscles are the vastest tissue in the human body with an essential role in maintaining posture, moving, and regulating internal body temperature and metabolism. Consequently, skeletal muscle injuries or diseases can have a profound effect on one’s life. In Advances in Skeletal Muscle Health and Disease, Fabio Arturo Iannotti has assembled contributions from international experts to provide a conclusive guide to what continues to be a rapidly developing research field. After a short introductory chapter, the book continues by looking at the biochemical, genetic, and molecular elements and mechanisms underlying skeletal muscle health and disease.

Go to the book

Advances in Skeletal Muscle Health and Disease

Edited by Fabio Arturo Iannotti

Chapters authored

Pharmacological Actions and Potential Therapeutic Use of Cannabinoids in Duchenne’s Muscular Dystrophy

By Fabio Arturo Iannotti

The scientific community uses the term endocannabinoid system (ECS) to refer to a large group of molecules that in our body control the production and function of the two major cannabinoid lipid mediators, namely, anandamide (AEA) and 2-arachidonoylglycerol (2-AG). Following their discovery, an impressive number of studies have shown that both AEA and 2-AG play a key role in a large plethora of functions in living organisms. Consequently, functional impairment or dysregulation of AEA and 2-AG activity leads to a variety of disorders affecting the nervous system as well as peripheral organs and tissues. For this reason, cannabinoids and/or cannabinoid synthetic drugs currently represent an important area of research for their potential therapeutic use to treat many human diseases having or not a genetic component. Despite these evidences, the role of the endocannabinoid system and hence potential changes in its activity in inherited muscular dystrophies remains largely unknown. Only recently, the role of endocannabinoid CB1 receptors was identified in Duchenne’s muscular dystrophy (DMD). In this chapter, I summarize the chemical properties and functional role of the endocannabinoids as well as plant-derived cannabinoids during skeletal muscle formation and repair under physiological conditions as well as DMD.

Part of the book: Muscular Dystrophies

Introductory Chapter: Skeletal Muscle Disorders – Emerging New Avenues for the Diagnosis and Treatment

By Fabio Arturo Iannotti

Part of the book: Advances in Skeletal Muscle Health and Disease

Fabio Arturo Iannotti

Latest work with IntechOpen by Fabio Arturo Iannotti

Advances in Skeletal Muscle Health and Disease

Chapters authored

Related collaborators

Samuel Honório

Tomoko Yamamoto

Marco Batista

João Serrano

Helena Mesquita

João Petrica

Jorge Santos

Jaime Ribeiro

Yoichiro Kato

Noriyuki Shibata