Open access peer-reviewed Edited Volume

Oncogenes and Tumor Suppressor Genes

Metin Budak

Trakya University

Dr. Budak is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of the Medicine Faculty. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.


Oncogene Proto-Oncogenes Cell Growth Differentiation Mutation Tumor Suppressor Gene Apoptosis Necrosis Methylation Acetylation Cancer Environment

Register your interest in contributing to this book

Collaborate with our community and contribute your knowledge.

About the book

Cell number in eukaryotic organisms; a unique balance between cell proliferation, differentiation, and apoptosis is achieved and maintained. Cancer is caused by mutational changes in critical regulatory genes that control these mechanisms. The main consequence of the deterioration of these systems is cancer. The earliest information on the molecular basis of cancer has emerged with studies on retroviruses. Although the majority of human cancers are due to carcinogenic effects of environmental factors, they are present in spontaneous or familial origin. A small portion of all cancers, such as 10-20%, are caused by viruses. The remaining majority is due to chemical or radioactive carcinogen exposure. Abnormal cell proliferation, such as cancer, is caused by other causes such as loss of balance between protooncogenes and tumor suppressor genes that stabilize cell proliferation, or errors during DNA replication. Some of these are due to epigenetic mechanisms.

The main purpose of this book is to create a resource book for all types of researchers, doctors, and students dealing with oncogenes and their functions by covering all oncogene mechanisms.

Publishing process

Book initiated and editor appointed

Date completed: April 23rd 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: May 21st 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Register for the book

Approved chapters written in full and submitted

Deadline for full chapters: July 20th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: October 8th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: December 7th 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Metin Budak

Trakya University

Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.

View profile

Book chapters authored 3

Books edited 1

Introducing your Author Service Manager

Mrs. Sara Gojević-Zrnić

As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

Ask a question

Book will be abstracted and indexed in