About the book
Cell number in eukaryotic organisms; a unique balance between cell proliferation, differentiation, and apoptosis is achieved and maintained. Cancer is caused by mutational changes in critical regulatory genes that control these mechanisms. The main consequence of the deterioration of these systems is cancer. The earliest information on the molecular basis of cancer has emerged with studies on retroviruses. Although the majority of human cancers are due to carcinogenic effects of environmental factors, they are present in spontaneous or familial origin. A small portion of all cancers, such as 10-20%, are caused by viruses. The remaining majority is due to chemical or radioactive carcinogen exposure. Abnormal cell proliferation, such as cancer, is caused by other causes such as loss of balance between protooncogenes and tumor suppressor genes that stabilize cell proliferation, or errors during DNA replication. Some of these are due to epigenetic mechanisms.
The main purpose of this book is to create a resource book for all types of researchers, doctors, and students dealing with oncogenes and their functions by covering all oncogene mechanisms.