About the book
Macrophages are ubiquitous and integrated part of both innate and adaptive immunity. These cells have been explored as extensive research tools in different contexts. Macrophages display a range of plasticity in their phenotype in different pathological conditions. Both peripheral and tissue macrophages together constitute the Reticuloendothelial system where they play major role in sensing pathogens and tumor antigens for their effective eradication. Out of various immune cells, macrophages display a range of plasticity which qualify them as one of potential target cells of body for the management of various human diseases clinically. Due to their plastic nature, these cells are literally involved in most of immunological and physiological process. Several groups including ours have demonstrated several MDR / XTR bacteria polarize M1 effector alveolar macrophages towards their M2 phenotype during their persistent infection. This seems to be the potential link to the sensitization for infection and may be for cancer development also.
Therefore the current mandate of research in macrophages immunobiology field mainly lies in the management of M1/M2 imbalance to minimize the risk of having cancer by chronic and persistent lung infection with intracellular pathogens like Chlamydia or Mycobacteria. This may be achieved by targeting major signaling pathways which drive M2 phenotype and are involved in cancer development e.g. Sphingolipids, Th2/Th17 responses.
In view of above, the major focus of this book is aimed to discuss research methodologies, resources / technologies by the dedicated biological community for identifying molecular signature involved in the polarization of M1 effector macrophages to M2 during disease. Within the umbrella of this ,the second major scope of this book is to explore how selective phenotype of macrophages would improve existing therapies with special emphasis at infection and cancer interface with special emphasis on lung cancers and various gastric inflammatory disease like IBD which are responsible for global mortality.
We invite scientists working on a cutting edge aspect of macrophages to submit their research to this project especially encouraging submissions that address macrophage-based therapeutic approaches.