Research Topic

Proteomics

PART OF IntechOpen Book Series: Biochemistry

ISSN 2632-0983

Research Topic on Proteomics - always open for submissions, with an Annual Volume published each calendar year with a dedicated ISSN and ISBN.

Led by Topic Editor Prof. Paolo Iadarola and an international Editorial Board, all submissions are peer-reviewed and published immediately after acceptance.

always open for submissions

Scope

With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.

keywords

Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE) Liquid Chromatography (LC) Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS) Proteins

Topic Editor

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Paolo Iadarola

University of Pavia, Italy

Topic Editor

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Simona Viglio

University of Pavia, Italy

Part of book series

Biochemistry

Publication details

DOI 10.5772/intechopen.72877

ISSN 2632-0983

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Contribute your work to the Topic Proteomics, always open for submissions. Your work will be published as part of the Annual Volume 2022, with a dedicated ISSN and ISBN.

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