Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the expression, structure, and function of molecular and cellular components. While a daunting task, learning is facilitated by identifying common, effective signaling pathways employed by nature to sustain life. As the primary example, the cellular interplay between intracellular Ca2+ increases and changes in plasma membrane potential is integral to coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating genetic expression. Further, in this manner, understanding the systemic interplay between the cardiovascular and nervous systems has become more important than ever as human populations age and mechanisms of cellular oxidative signaling are utilized for sustaining life. Altogether, physiological research enables our identification of clear and precise points of transition from health to the development of multi-morbidity during the inevitable aging process (e.g., diabetes, hypertension, chronic kidney disease, heart failure, age-related macular degeneration; cancer). With consideration of all organ systems (e.g., brain, heart, lung, liver; gut, kidney, eye) and the interactions thereof, this Cell Physiology Series will address aims to resolve (1) Aging physiology and progress of chronic diseases (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling and (3) How changes in plasma membrane produced by lipid peroxidation products affect aging physiology.
Neurodevelopment and Neurodevelopmental Disease Free Radicals Tumor Metastasis Antioxidants Essential Fatty Acids Melatonin Lipid Peroxidation Products and Aging Physiology