The potential plant compounds as botanical pesticides and respective target pests.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7210",leadTitle:null,fullTitle:"New Trends in High Voltage Engineering",title:"New Trends in High Voltage Engineering",subtitle:null,reviewType:"peer-reviewed",abstract:"For public access to electric energy, exploitation of high-voltage networks is inevitable. Meanwhile, high-voltage engineering plays a basic role in designing and operating network insulation. On the other hand, modern high-voltage engineering trends are developing environmentally friendly and recyclable insulators. Recently, nano-doping of environmentally friendly polypropylene/inorganic nano-composites has shown improvement to its characteristics and increased the use of HVDC insulation. In this book, research is carried out on nano-doping effects on the performance and future development of polypropylene nano-composites. Also, the characteristics of CF3I gas and its combination with nitrogen by experimental results are investigated. Installation of capacitors may result in voltage increment at the point where the capacitors are connected to the network. This issue is important when a harmonic resonance has occurred. The harmonic resonances may lead to voltage stress on the power network insulation. The book also discusses the effect of harmonic resonance on the insulation.",isbn:"978-1-78984-903-5",printIsbn:"978-1-78984-902-8",pdfIsbn:"978-1-83881-769-5",doi:"10.5772/intechopen.74085",price:100,priceEur:109,priceUsd:129,slug:"new-trends-in-high-voltage-engineering",numberOfPages:68,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"a6e25d2b75bbeb9b7e4719aa5d90e58c",bookSignature:"Reza Shariatinasab",publishedDate:"December 19th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/7210.jpg",numberOfDownloads:4531,numberOfWosCitations:2,numberOfCrossrefCitations:5,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:7,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:14,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"January 23rd 2018",dateEndSecondStepPublish:"April 5th 2018",dateEndThirdStepPublish:"June 4th 2018",dateEndFourthStepPublish:"August 23rd 2018",dateEndFifthStepPublish:"October 22nd 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"110072",title:"Prof.",name:"Reza",middleName:null,surname:"Shariatinasab",slug:"reza-shariatinasab",fullName:"Reza Shariatinasab",profilePictureURL:"https://mts.intechopen.com/storage/users/110072/images/6589_n.jpg",biography:"Reza Shariatinasab received the B.S. degree in electrical engineering from Ferdowsi University, Mashhad, Iran, in 2000, and the M.S. and Ph.D. degrees in electrical engineering from Amirkabir University of Technology, Tehran, Iran, in 2003 and 2009, respectively. In September 2007, he was a Visiting Scientist with Doshisha University, Kyoto, Japan.\nIn 2009, he joined the Electrical and Computer Eng. Department, University of Birjand, Birjand, Iran, where he is currently a Professor of Electrical Engineering. He is the author or co-author of 2 books, one book chapter, and more than 100 scientific papers published in reviewed journals and presented at international conferences. His research interests include High voltage engineering and Lightning transients.\nProf. Shariatinasab is a senior member of IEEE.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Birjand",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"116",title:"Electrical and Electronic Engineering",slug:"electrical-and-electronic-engineering"}],chapters:[{id:"63145",title:"Introductory Chapter: New Challenges in High-Voltage Engineering",doi:"10.5772/intechopen.80623",slug:"introductory-chapter-new-challenges-in-high-voltage-engineering",totalDownloads:1333,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Reza Shariatinasab",downloadPdfUrl:"/chapter/pdf-download/63145",previewPdfUrl:"/chapter/pdf-preview/63145",authors:[{id:"110072",title:"Prof.",name:"Reza",surname:"Shariatinasab",slug:"reza-shariatinasab",fullName:"Reza Shariatinasab"}],corrections:null},{id:"62889",title:"A Review of Polypropylene and Polypropylene/Inorganic Nanocomposites for HVDC Cable Insulation",doi:"10.5772/intechopen.80039",slug:"a-review-of-polypropylene-and-polypropylene-inorganic-nanocomposites-for-hvdc-cable-insulation",totalDownloads:1241,totalCrossrefCites:5,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Due to its excellent electrical and thermal performance, as well as satisfying the needs for developing the environmentally friendly and recyclable cable insulation material, polypropylene has caused widespread concern. Nanodoping can effectively improve the electrical, thermal and mechanical properties of polypropylene nanocomposites, which provides a new method to solve the problems in its application in HVDC cable insulation. This chapter introduces research achievements on polypropylene and polypropylene/inorganic nanocomposites, which states the effects of nanodoping on the electrical properties, such as space charge behaviors, electrical tree aging, breakdown strength, etc. thermal conductivity and mechanical properties of the polypropylene and its multi-blends. The aging mechanism under different conditions is also discussed. The analysis shows that the surface treatment of nanoparticles can reduce the aggregation of nanoparticles and strengthen the interface effect, thus improving the comprehensive properties of polypropylene nanocomposites. This chapter also summarized the feasibility and future development of the polypropylene and its nanocomposites application in the insulation of HVDC cables.",signatures:"Boxue Du, Zhaohao Hou and Jin Li",downloadPdfUrl:"/chapter/pdf-download/62889",previewPdfUrl:"/chapter/pdf-preview/62889",authors:[null],corrections:null},{id:"63281",title:"The Performance of Insulation and Arc Interruption of the Environmentally Friendly Gas CF3I",doi:"10.5772/intechopen.79968",slug:"the-performance-of-insulation-and-arc-interruption-of-the-environmentally-friendly-gas-cf3i",totalDownloads:1030,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Many researches of trifluoroiodomethane (CF3I) have shown that CF3I has many excellent properties that make it one of the possible alternatives of SF6. This paper reveals the effect laws of CF3I gas content, gap distance, gas pressure, polarity, and electric field nonuniform coefficient on the insulation performance of CF3I gas mixtures. In general, CF3I-N2 gas mixtures present a superior dielectric strength than CF3I-CO2 under different electric field sets. The experimental results indicate that 20 and 30% content CF3I-N2 gas mixtures can achieve nearly 50 and 55% insulation strength of pure SF6. In addition, to evaluate the arc interruption performance of environmentally friendly gas CF3I, we set up a CF3I transient nozzle arc model to study its thermodynamic and transport property. The analysis shows that CF3I gas has a good arc interruption capability, which mainly functions thermodynamic and transport properties approach that of SF6, and some are even better than SF6. The decomposition process is also aggravated by impurities including metal and water. The main by-products are greenhouse gases with GWP below that of SF6 and are lowly toxic and incombustible.",signatures:"Dengming Xiao",downloadPdfUrl:"/chapter/pdf-download/63281",previewPdfUrl:"/chapter/pdf-preview/63281",authors:[{id:"18115",title:"Dr.",name:"Dengming",surname:"Xiao",slug:"dengming-xiao",fullName:"Dengming Xiao"}],corrections:null},{id:"63732",title:"Analysis for Higher Voltage at Downstream Node, Negative Line Loss and Active and Reactive Components of Capacitor Current, and Impact of Harmonic Resonance",doi:"10.5772/intechopen.80879",slug:"analysis-for-higher-voltage-at-downstream-node-negative-line-loss-and-active-and-reactive-components",totalDownloads:927,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In a study, it was found that the voltage at the downstream node is higher than the voltage at the upstream node, even though all the current flows from the upstream node to the downstream node. In IEEE’s load flow simulation results for the 13-bus system, 34-bus system, and 123-bus system, it was also found that line losses in some feeders are negative. In this chapter, it has been analyzed how higher voltage at the downstream node and negative line losses in a phase appear in an AC power system. It has also been demonstrated that even though a capacitor generates only reactive power, its current has both active and reactive components with respect to the system reference. Finally the impact of harmonic resonance on capacitor has been discussed.",signatures:"Sushanta Paul",downloadPdfUrl:"/chapter/pdf-download/63732",previewPdfUrl:"/chapter/pdf-preview/63732",authors:[null],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6515",title:"Emerging Waveguide Technology",subtitle:null,isOpenForSubmission:!1,hash:"12ab2b13b1ca330409dc239647a53895",slug:"emerging-waveguide-technology",bookSignature:"Kok Yeow You",coverURL:"https://cdn.intechopen.com/books/images_new/6515.jpg",editedByType:"Edited by",editors:[{id:"188673",title:"Dr.",name:"Kok Yeow",surname:"You",slug:"kok-yeow-you",fullName:"Kok Yeow You"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6362",title:"Electric Field",subtitle:null,isOpenForSubmission:!1,hash:"70b535bf877d17b46ddd1678574792a0",slug:"electric-field",bookSignature:"Mohsen Sheikholeslami Kandelousi",coverURL:"https://cdn.intechopen.com/books/images_new/6362.jpg",editedByType:"Edited by",editors:[{id:"185811",title:"Dr.",name:"Mohsen",surname:"Sheikholeslami Kandelousi",slug:"mohsen-sheikholeslami-kandelousi",fullName:"Mohsen Sheikholeslami Kandelousi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6603",title:"Actuators",subtitle:null,isOpenForSubmission:!1,hash:"33056f58590b5920dd938eff4810e8dc",slug:"actuators",bookSignature:"Constantin Volosencu",coverURL:"https://cdn.intechopen.com/books/images_new/6603.jpg",editedByType:"Edited by",editors:[{id:"1063",title:"Prof.",name:"Constantin",surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9290",title:"Applied Electromechanical Devices and Machines for Electric Mobility Solutions",subtitle:null,isOpenForSubmission:!1,hash:"2e50c2d9cf3922f5f8fff01aaef1053e",slug:"applied-electromechanical-devices-and-machines-for-electric-mobility-solutions",bookSignature:"Adel El-Shahat and Mircea Ruba",coverURL:"https://cdn.intechopen.com/books/images_new/9290.jpg",editedByType:"Edited by",editors:[{id:"193331",title:"Dr.",name:"Adel",surname:"El-Shahat",slug:"adel-el-shahat",fullName:"Adel El-Shahat"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Avila Bernal",coverURL:"https://cdn.intechopen.com/books/images_new/7253.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"193020",title:"Dr.",name:"Jaime Andres",middleName:null,surname:"Perez Taborda",slug:"jaime-andres-perez-taborda",fullName:"Jaime Andres Perez Taborda"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"33329",title:"Prof.",name:"guifu",middleName:null,surname:"Ding",fullName:"guifu Ding",slug:"guifu-ding",email:"gfding@sjtu.edu.cn",position:null,institution:{name:"Shanghai Jiao Tong University",institutionURL:null,country:{name:"China"}}},{id:"244624",title:"Associate Prof.",name:"Congchun",middleName:null,surname:"Zhang",fullName:"Congchun Zhang",slug:"congchun-zhang",email:"zhcc@sjtu.edu.cn",position:null,institution:null},{id:"255541",title:"Mr.",name:"Jianze",middleName:null,surname:"Huang",fullName:"Jianze Huang",slug:"jianze-huang",email:"huangjz420@sjtu.edu.cn",position:null,institution:null},{id:"255547",title:"Mr.",name:"Chunsheng",middleName:null,surname:"Yang",fullName:"Chunsheng Yang",slug:"chunsheng-yang",email:"csyang@sjtu.edu.cn",position:null,institution:null}]},book:{id:"7253",title:"Coatings and Thin-Film Technologies",subtitle:null,fullTitle:"Coatings and Thin-Film Technologies",slug:"coatings-and-thin-film-technologies",publishedDate:"January 3rd 2019",bookSignature:"Jaime Andres Perez-Taborda and Alba G. Avila Bernal",coverURL:"https://cdn.intechopen.com/books/images_new/7253.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"193020",title:"Dr.",name:"Jaime Andres",middleName:null,surname:"Perez Taborda",slug:"jaime-andres-perez-taborda",fullName:"Jaime Andres Perez Taborda"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11932",leadTitle:null,title:"New Materials and Enhanced Performance of Sodium-Ion Batteries",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tBecause sodium is abundant in nature compared to lithium and cost-effective, Li-ion batteries are being replaced by Na-ion batteries. However, the ability of battery components to improve battery performance is still the biggest problem. Also, sodium has a larger atomic radius than lithium, it has inevitably limited its practical applications, created problems of low electrochemical reaction kinetics, and reduced cyclic stability for sodium-ion batteries. Although the design of new materials, the porosity, and 3D-printing of electrodes with applying structural engineering/modification and especially the solid-state production of electrolyte provide serious benefits to improve the Na-ion battery performance, it can still be said that it doesn’t give the desired outcome.
\r\n\r\n\tThis book aims to provide the most up-to-date and latest approaches to solving these problems, as well as to provide new solutions that may come across in the coming period. The systematic presentation of the roles and effects of effective strategies will also make the study interesting.
",isbn:"978-1-80356-498-2",printIsbn:"978-1-80356-497-5",pdfIsbn:"978-1-80356-499-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"75c27a6f2739e8af817bace95b0e50d6",bookSignature:"Ph.D. Fatma SARF",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11932.jpg",keywords:"Cathode, Anode, Separator, Electrolyte, Nanofibers, Nanocarbon, Polymers, Solid-State, Rate Capability, Specific Capacity, Stability, Charge-Discharge Time",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 4th 2022",dateEndSecondStepPublish:"May 5th 2022",dateEndThirdStepPublish:"July 4th 2022",dateEndFourthStepPublish:"September 22nd 2022",dateEndFifthStepPublish:"November 21st 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Ph.D. Fatma Sarf has 13 SCI/SCI-Expanded articles, 1 book chapter, 1 international scholarship, and 1 young entrepreneur award. Member of Çanakkale.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"245850",title:"Ph.D.",name:"Fatma",middleName:null,surname:"SARF",slug:"fatma-sarf",fullName:"Fatma SARF",profilePictureURL:"https://mts.intechopen.com/storage/users/245850/images/system/245850.png",biography:null,institutionString:"Çanakkale Onsekiz Mart University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Çanakkale Onsekiz Mart University",institutionURL:null,country:{name:"Turkey"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"455410",firstName:"Dajana",lastName:"Jusic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/455410/images/20500_n.jpeg",email:"dajana.j@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"61433",title:"Essentials in Accident and Emergency Medicine Radiation Injury: Response and Treatment",doi:"10.5772/intechopen.76863",slug:"essentials-in-accident-and-emergency-medicine-radiation-injury-response-and-treatment",body:'\nDespite safety precautions and application of modern standards of radiation protection, injury from radiation can be generated from both intentional and unintentional situations and events. Injury can be catastrophic, immediately life-threatening, and survivors of exposure remain with a lifetime risk of secondary events including chronic health changes and malignancies. Even with the development of radiation protection standards and oversite organizations, accidents and misadministration of radiation deviant from intent continue to haunt daily application of radiation therapy. There is no antidote to radiation exposure and the fingerprints of injury remain for a lifetime. In this chapter we will review major incidents of public radiation exposure and accidents in history including cause and effect. We will review the application and evolution of standards and how this affects both the public and healthcare worker in modern care. We will review modern patient care and response assessment to radiation exposure including agents that may protect or mitigate radiation damage from radiation exposure. We will identify strengths of modern radiation therapy and the need for continuous process improvements to ensure optimal application of X-ray in a safe environment.
\nX-rays were discovered in 1895 by William Roentgen. In part due to the century old use of electricity in medicine, X-rays were rapidly assimilated into the medical armamentarium portfolio as beneficial applications of X-ray treatment were identified by early radiologists. Due to protracted exposure times and minimal knowledge of risk, early practitioners of the application of X-rays to treatment situations became victims themselves. Friedrich Otto Walkoff took the first dental radiograph in 1895 by placing a photographic plate between his teeth and tongue. He was able to generate an image with a 30-minute exposure time. He applied similar techniques to patients and reported epilation and skin blistering. Walkoff developed the first dental imaging laboratory in 1896 with Fritz Geisel. Geisel died in 1927 of metastatic carcinoma caused by heavy exposure of radiation to his hands. In 1896, a child was accidently shot in the head and was brought to a laboratory at Vanderbilt University (Nashville, TN). Investigators sought the location of the bullet by X-ray and a plate holder was tied to the head of the patient. The X-ray tube was placed at the patient’s head. The exposure was 1 hour. About 21 days after exposure there was epilation at the site of X-ray application. In 1896, HD Hawkes gave a demonstration of an X-ray unit in New York City. He had to discontinue work after 4 days due to injury to the skin of his hand and chest. Within 2 weeks he had significant skin injuries, his fingernails deteriorated, and he exhibited systemic signs of radiation injury. In the same year, William Levy sought out to localize a bullet that had been lodged in his skull for 10 years. He was warned about the potential of injury; however, chose to move forward. Images were created over a 14-hour period from three static positions at his forehead, his open mouth, and behind his right ear. Within 24 hours, the dermal surfaces of his head were blistered and within days his mouth and lips had sores and epilation occurred within 3 weeks. The bullet was found within an inch of the occipital protuberance. In this circumstance, the absorbed dose by the victim was at least 15 Gray (Gy). Clarence Dally worked at the Edison laboratory and had the role of being a glassblower for Thomas Edison. He is thought to be the first individual to die from chronic radiation workplace exposure in 1904 from metastatic carcinoma at the age of 39. It is thought that his exposure was at least 30 Gy. Numerous deaths were reported in X-ray manufacturers and workers with noted deaths of Nobel Laureates Marie Curie and her daughter Joliot Curie from radiation-associated diseases during the discovery of radium in 1898 and the near immediate application of radium to treat cancer.
\nWhile the benefits of the application of radium and X-rays were moving forward, the risk of injury was continually recognized at an international level. At the second international congress of radiology in 1928 held in Stockholm, Sweden, participating countries developed standards for radiation protection. These were centered on recommendations from the United Kingdom as guidelines for radiation protection had been employed for the previous decade. The congress established the International X-Ray and Radium Protection Committee which was remodeled after World War II (WWII) into two commissions that are active today. These are the International Commission on Radiological Protection (ICRP) and the International Commission on Radiation Units and Measurements (ICRU). In the United States today, the Environmental Protection Agency (EPA) is charged with the responsibility for providing guidance to federal agencies. The Nuclear Regulatory Commission (NRC) formulates rules for application of product materials and the Department of Energy is responsible for radiation safety regulations through the NRC. Multiple international agencies participate in radiation safety activities and help shape policy including health applications and strategy for nuclear energy [1, 2, 3, 4].
\nAs the benefits and power of X-rays and radium matured, the use of nuclear tools for weapons of mass destruction came to power. During WWII, efforts for harnessing nuclear power for destruction reached application on August 6, 1945 with the use of a 9000-pound uranium-235 bomb known a “Little Boy” over the manufacturing city of Hiroshima, Japan. The bomb was dropped with a parachute and detonated 2000 feet above the city with blast equal to 15 kilotons About 2–3 days later, a plutonium-239 bomb known as “Fat Man” was dropped over the city of Nagasaki. The primary target was Kokura; however, clouds shrouded the primary target area. The plutonium bomb was more powerful than the bomb used on Hiroshima. The bomb weighed 10,000 pounds and produced a 22-kilotons blast. The topography of Nagasaki limited the radius of impact as the city is in a narrow valley between mountains. Initial destruction and death was due to heat and fire as well as associated trauma related to building damage and other structural/public health-related matters; however, those not at the epicenter of the blast were exposed to radiation as a function of distance from the epicenter. Early impact resulted in microcephaly and mental retardation in the most vulnerable unborn and young population with lifelong health risks including chronic health issues in multiple organ systems and cancer risks affecting all survivors. We have earned much about studying the population of survivors and have been able to apply this knowledge to risk assessment for the general population, healthcare workers, and pregnant/potentially pregnant patients [5, 6, 7].
\nAfter WWII, there was a significant interest in accelerating the production of nuclear weapons as well as promoting the use of nuclear energy in lieu of fossil fuels and other sources of non-renewable energy reserves. While we knew individual risk of the indiscriminate use of radiation, despite the application of nuclear weapons, little was known about the impact of risk upon the general population about accidents in the application of nuclear power and the secondary development of nuclear weapons.
\nThe International Atomic Energy Agency (IAEA) maintains as website reporting nuclear accidents. As of 2014, there have been more than 100 serious accidents associated with the use of nuclear power. It is worrisome that more than 50% of the accidents have occurred since the accident at Chernobyl (1986) and that more than 60% of the accidents reported have occurred in the United States. These accidents have occurred over time due to many circumstances including poor design of the reactor and human judgment error in the attempt to prevent and mitigate the problem. Many of the most serious events will be described as follows [5, 6, 7].
\nIn 1946, Canadian investigators evaluating nuclear weapons brought two hemispheres of neutron-reflective beryllium around a plutonium core. The hemispheres were only separated by a screwdriver which was against policy. The screwdriver slipped which set off a chain reaction filling the room with radiation validated by the presence of blue light. Louis Slotin (physicist) rapidly separated the hemispheres preventing further exposure to co-workers; however, he died of radiation exposure 9 days later [5].
\nThis event was a radioactive decontamination accident in 1957. The accident occurred at Mayak which was a plutonium production site in the eastern Ural Mountains in the Soviet Union. The actual site was not marked on topographical maps, therefore the accident is named after a nearby town.
\nBecause the Soviet Union was behind the US in the development of uranium and plutonium nuclear weapons, the facility was constructed over a short period of time between 1945 and 1948. Initially, high levels of radioactive material were dumped into a nearby river which flowed into the Arctic Sea. The reactors (six) were located on a lake which was used for the cooling cycle. The primary lake was Lake Kyzyltash which became quickly contaminated and a secondary lake, Lake Karachay, also quickly became contaminated. A storage facility for liquid waste was built in 1953. It was a simple design with steel tanks mounted in concrete base 27 feet underground. Because the nuclear waste generated heat, a cooling system was built around each tank. Facilities for monitoring the operation were primitive.
\nOn the day of the event, the cooling system failed in one of the tanks containing 80 tons of liquid radioactive waste. The liquid evaporated, and an explosion ensued estimated at 1 kiloton. A 160-ton concrete lid was thrown into the air and an estimated 20 Millicuries (mCi) of radioactivity was released. Although most of the contamination was near the explosion, there was a plume of radionucleotides that spread over hundreds of miles through the air. The long-term contamination area is estimated to be more than 7000 square miles including cesium 137 and strontium 90. It is estimated that 22 villages were affected, and more than 10,000 people were evacuated from the site over a 2-year period. Due to secrecy surrounding the incident and limitations in obtaining documentation, estimates of health damage, cancer, and current conditions can only be estimated. It is known that the East Ural region remains contaminated to this day and there were scores of documented cases of chronic radiation syndrome with an elevated cancer rate including a high rate of death due to malignancy.
\nIn this situation, limited knowledge of reactor safety coupled with poor risk assessment resulted in an accident of significant magnitude, third only to the accidents at Fukashima and Chernobyl [5, 6, 8].
\nIn a similar manner, the British government initiated a nuclear weapons program after WWII using a plutonium-based platform. British physicists were involved in the Manhattan project and two reactors were built near the village of Seascale, UK, a few hundred feet apart from each other. The core of the reactors consisted of a large block of graphite with channels built for transport of uranium cartridges which would be pushed posteriorly into the back channel for cooling in a water filled channel. This was different from previous designs which had a constant supply of water that poured through the channels housed in the graphite. The first design was chosen because of fear of malfunction of the need for the constant water source. Filters were placed in situ in case one of the cartridges broke entering the water. Without water in the channels, cartridges did break and despite filters, radioactivity was documented around the site but not indicated to staff. One of the reactors was prone to heating and this was believed to be related to the graphite. It was known that neutrons created small fractures in the graphite which in turn could be annealed with increasing the heat of the system. This was known as the Wigner effect, named after physicist Eugene Wigner.
\nThere was considerable political pressure for quickly producing a weapon and the decision was made to generate Tritium which required augmented heating in the reactor. To produce Tritium, the cooling fins on the plutonium cannisters decreased in size to increase heat exchange. Windscale was modified by adding enriched uranium and lithium-magnesium to the fuel rods making the situation more vulnerable to combustion.
\nOn October 7, 1957, one of the reactors was heating more than norm and an additional Wigner annealing release was performed. This had the anticipated result except for one channel. A second Wigner release was performed which appeared to stabilize the situation. On October 10, 1957, a radiation detector in the chimney indicated a release of radiation. It was assumed that a rod had fractured. What was not recognized was the presence of a fire in the same channel likely started on October 7. To provide cooling, fans were augmented which unintentionally made the situation worse. Carbon dioxide and water did not extinguish the fire. It was estimated that 11 tons of uranium was ablaze. Leaders ordered evacuation and shut off all ventilation entering the reactor. This was successful and water flowing through the reactor was cold within 24 hours.
\nRadioactive material including Iodine 131 (740 Terabecquerel (TBq)), Cesium 137 (22 TBq), and Xenon 133 (12,000 TBq) was released. The presence of scrubbers and filters in the chimney proved to be important and likely limited damage. Both reactors were deemed unsafe for continued use and fuel was removed in 2012 [5, 6].
\nSL-1 was a US Army nuclear power reactor located at the national reactor testing station 40 miles west of Idaho Falls, Idaho. The reactor became operational in 1958. The reactor used enriched uranium fuel and was cooled by water flowing through plates of uranium/aluminum alloy. The design relied on a primary central fuel rod. The reactor was closed for maintenance on January 3, 1961 and was being prepared to restart after the 11-day shutdown. Procedures that required the central rod be withdrawn to connect to the central drive mechanism. The rod was withdrawn too far, and the reactor instantly became critical. Within 4 milliseconds, the heat generated by the power excursion caused water to vaporize and explode. Radioactive water became a pressure wave striking the ceiling and a loose metal pin impaled one of the workers to the ceiling structure. It was determined on review that the 26,000-pound internal vessel had moved more than 9 feet in the superior direction and the control rod mechanisms struck the ceiling. There were three workers on site who each died quickly of their injuries. Their radiation exposure would also have been lethal, if they survived physical trauma. Review of the incident suggested that the central rod may have become fixed in position and one of the workers was able to free it; however, in the process the rod moved too far which generated the reaction.
\nEven without a containment structure, the reactor contained most of the radioactivity. In late 1961, the cleanup process began and all core and building materials were buried approximately 1600 feet from the site of the reactor. One of the conclusions was that design focus on a single central structure created untoward risk that could not be easily mitigated. First responders may have received significant compounded radiation dose due to increased radiation dose in the environment and during removal of the waste and remains of those who died. Those involved in the response were awarded certificates for heroism [5, 6].
\nDuring the evening of March 27, 1979, one reactor at Three Mile Island nuclear station was running at near full capacity, while a second reactor was shut down for re-fueling. The root cause of the accident occurred 11 hours prior to the declaration of the emergency, when the cooling system filters were cleaned with air compression and cooling water. A valve that was thought to be shut was open and water entered an instrument airline which caused a turbine trip. Three auxiliary pumps should have been activated when heat and pressure increased due to lack of cooling; however, these pumps were closed due to re-fueling. This was not NRC policy. A third valve opened to relive pressure; however, did not close when pressure was released, therefore coolant escaped and became root cause in core disintegration. Human factors delayed recognition of the problem as a light indicated that the open valve was closed and secondary safety procedures were not followed. Even though there was persistent loss of coolant, water levels increased through the open valve creating bubbles of steam in the liquid. At 4:15 am on March 28, 1979, the pressurizer in the relief tank ruptured and radioactive coolant leaked into the containment structure. In a series of activated pumping mechanisms, the coolant was then pumped beyond the containment area. At 6 am on March 28, 1979, the temperature in a pilot valve was noted to be excessive by an employee beginning his work shift and a back valve was used to stop the flow of coolant. However, by that time 32,000 gallons of coolant had leaked, and radiation levels were 300 times expected. The containment building was significantly damaged; however, the radioactive material remained in situ as it did not extend beyond the reactor vessel despite that approximately half of the core uranium melted during the incident.
\nThe incident became an example of managing authority and responsibility in the nuclear industry. Lines of authority between private plant ownership, state authorities, and the NRC were not clear and accordingly in the early phase of the accident, it was difficult to obtain accurate information for risk assessment. This resulted in delayed evacuation. Clean up was not completed for more than a decade and long-term risks remain not well defined. Most of radioactive gas release was xenon, which was not considered significant; however, radioactive iodine was also released and the impact of increase in thyroid cancers remains uncertain [5, 6].
\nThe Chernobyl accident is one of the two most significant nuclear events in the history of unintentional radiation injury. The incident occurred on April 26, 1986. The irony of the event is that it occurred during a safety procedure evaluation and safety systems were intentionally disabled as part of the intended procedure. The reactor was brought to minimal activity with the expectation that cooling systems would manage the heat generated by thermal decay. The systems onsite unfortunately required more than 1 minute to activate and running the reactor at minimal power (below safety standard) resulted in the crisis. A series of events triggered by flaws in reactor design and poor decisions made by onsite personnel created situation where reactor cooling was inefficient and two steam explosions generated from thermal decay exposed the graphite core to air, which fueled the massive explosion. Exposure to oxygen fueled the explosion. The fires were extraordinary and sent radioactive elements and gas into the air for a week. Plumes of radioactive gas extended well into Western Europe for an extended period of time. Casualties were significant including first responders attempting to put out the fires as those involved were exposed to lethal levels of radiation. Scores of people were affected by radiation syndrome and estimates include thousands who will develop secondary cancers due to exposure. Cleanup continued for decades. It is estimated that more than 350,000 people relocated as part of a series of evacuations. Unfortunately, many evacuated during the initial phase of the accident were exposed to medically significant radiation as the exit road was directly under the parallax of the radioactive plume from the reactor fires. Reactor fires were eventually attenuated by helicopter droppings of cement, clay, sand, and boron to absorb neutron activity. The government decided to place a cover over the remains of the reactor and today this is referred to as a sarcophagus. Full understanding of risk and damage remains elusive due to limited access to information and lack of full disclosure for years by government sources [5, 6].
\nThe nuclear power plant at Fukashima sustained damage from a massive Tsunami 50 minutes after the Tohoku earthquake in 2014. At the time of the earthquake, a mandatory shutdown of the reactor took place; however, decay heat, despite the elimination of the fission component of the reactor energy generation, needed to be managed and cooled with backup generators and power. The secondary backup cooling systems were damaged in three of the reactors and consequently, heat generated explosions contaminated the environment with radioactive particles and gas. Unlike Chernobyl, three had no direct deaths associated with the explosions and radiation exposure; however, issues with the cleanup continue until today. In the construction of Fukashima, more advanced backup systems existed in modern construction sites and these withstood the injury. The affected reactor had an older cooling design. Deaths occurred as part of the evacuation process, due in part to damage to facilities and inability to move rescue supplies into the region. This also compromised restoring the cooling mechanisms to the backup systems as batteries and generators that may have been helpful could not be transported to the site. The damage to the environment continues to today. Fukashima and Chernobyl are considered as two most powerful nuclear accidents in our history [5, 6].
\nThe experiences listed depict the extraordinary damage created by nuclear accidents to people and the environment. Reactor design, poor secondary cooling backup systems for failure, poor response by onsite providers with decisions made in panic, and natural disasters with poor preparation have created an uncertain future for the safety and durability of nuclear power. Injuries for onsite providers are related to explosions, thermal and high dose radiation. The incidents can occur in fractions of seconds and the injuries and environmental impact can last generations. It is sobering to see the radiation injuries sustained by first responders and those who attempted to mitigate the disasters. Information for these people arriving onsite for disaster management was not clear and in retrospect was inaccurate. Their brave and self-sacrificing response could not overcome the power and danger imposed by the situation. The impact on the nearby population and environment will not be resolved for decades and the disaster at early accidents continues to haunt the environment. The impact on the lives of the victims has no clear limit or statute of limitations. We need improved safety, infallible design, and protective strategies moving forward. In the upcoming sections, we will describe what information is currently available for those involved in the triage of radiation injury for both acute and long-term injuries [5, 6, 7, 8, 9, 10, 11].
\nWith the interest in nuclear power, efforts were developed to use nuclear power for transportation. Submarine technology for nuclear power was developed as it limited the need to refuel and missions could be extended for a significant period. However, as such issues and safety within the nuclear power community, safeguards, and measures of protection could not be provided with security. In the Soviet submarine fleet, many accidents occurred which limited the safety and security of the power source. In 1961, similar to a nuclear power plant, the cooling system failed on the K-19 Soviet nuclear submarine and the temperature rapidly rose as a result of decay heat. The captain ordered a secondary cooling built and sailors/engineers in the process of building a cooling system were exposed to lethal doses (LDs) of radiation in the process of building the system. More than 20 died of radiation injury. In 1968, nine sailors died during an explosion that released radioactive gas. In 1985, 10 died in an explosion caused by malfunction of a lid designed to keep fuel rods in position and 49 people were exposed to significant radiation, many of whom were first responders to the explosion and subsequent fire. These events demonstrated that safety precautions including well understood policy and procedure were and remain essential to mission if nuclear energy sources were being used [5].
\nIn this section, we will describe a series of events that imposed injury to people and the environment from applications of therapeutic radiology and unintended overuse of imaging equipment. These events have significant consequence to unintended victims of equipment, safety measures, and human error.
\nIn 1984, an Irridium-192 radioactive source became dislodged from the safety container. A worker unintentionally took the source back to his residence which exposed himself, his family, and visitors to high doses of radiation with three people sent to the Curie institute for treatment. It is believed that eight deaths were caused by the accident and there is a report that some deaths were due to pulmonary hemorrhage. Similar injuries have been reported in patients with myeloma undergoing total body radiation therapy as part of preparation for bone marrow transplant noted at doses of less than 10 Gy [5, 11].
\nIn 1985, a Cesium-137 source was inadvertently left behind when a private radiation oncology clinic moved to a new facility. The source was found 2 years later by two people who brought the source and source carriage home and eventually ruptured the capsule of the source. During this time, hundreds of people were exposed and at least four died of radiation-related injuries. Cleanup processes took 6 months and at least 300 people were identified as having exposure to Cesium [5].
\nOn December 7, 1990, maintenance was performed on a linear accelerator at the radiation therapy clinic at Zaragoza, Spain and it returned to patient care service on December 10. What was not known was the accelerator (14 years in service) was incorrectly repaired and there was a breakdown in the internal control mechanism, therefore not detecting that patients were receiving much higher doses than specified with a higher beam energy. Initially, after 10 days of treatment, patients were identified as having accelerated dermal injuries. The first death associated with radiation injury was in February 1991. In total, 25 patients died in the first year after the event and 11 were attributed to injuries imposed by the incident [5].
\nIn 1989, an accident occurred in a facility using a Co-60 source to sterilize medical products. The device became frozen in the on position. The worker by-passed safety measures and entered the room with two other workers to try and free the equipment. The exposure was so high that one worker died within 6 months of exposure and the two other workers sustained injuries requiring amputation [6, 7, 9].
\nThe modern linear accelerator has a vast array of safety features including computer override systems which prevent improper application of therapy and internal monitoring diodes which monitor dose application. Safe operation of linear accelerators is a challenging task and users of modern equipment have to assume greater responsibilities for safe execution of patient care. Complex treatment plans and delivery system require thorough hands on understanding of machine operations and safety systems. Continuous process monitoring ensuring safe delivery of care is essential to mission to prevent abhorrent behavior of equipment. This includes well trained staff who can detect potential issues and report concerns to appropriate individuals for next step action to mitigate potential problems. Nevertheless, significant errors have occurred which continue to haunt patient care delivery. Advancement in therapy application often require tools that are developed by different companies and the tools must be harmonized through hardware and software adjustments to provide appropriate patient care. This has led to serious and life-threatening injuries when not applied appropriately. The most common errors in computer override situations are software flaws that indicate that a situation is safe when it is unsafe. Examples of software flaws include unintentionally reporting that multileaf jaws are moving appropriately during treatment when they are not and assuring the individual delivering therapy that system delivery is compliant to plan and calculation when the situation may be less secure. Treatments now require thousands of dynamic motions of individual leaves hidden in the gantry of the machine. Linear accelerators and radiation therapy treatment planning have become exceptionally complex. Treatment delivery capability has become exceptionally precise in its capability to deliver very high doses of treatment to small areas with submillimeter precision. The power of the new equipment is extraordinary; however, the power is often used as a marketing tool and does not recognize that new systems including training of personnel have not been appropriately vetted. This represents both the strength and weakness of modern care. The instrument is powerful; however, if not applied appropriately can cause significant harm. If not calibrated and executed properly, life-threatening injuries occur. In recent reporting through the New York Times, Walter Bogdanich accurately reported on misadministration of radiation therapy to multiple patients in several separate situations causing severe injury and death including injuries to tissues that could not be repaired. These are the innocent victims of our technology and their injuries are a sobering reminder that we must maintain a culture of safety [12].
\nAlthough software matters can be addressed, we must improve on right patient and right treatment. Human error remains too frequent in treatment delivery. Technology cannot resolve all causes of error and department processes including double identification and time out must be documented and validated to ensure patient safety. More sophisticated digital identification processes may be implemented into clinical operation including iris and fingerprint strategies for identification, similar to modern computer identification technologies. Written policies and validation that processes have been followed are crucial to successful clinical operation. Recent review of adverse events of radiation oncology devices from 1991 to 2015 revealed that adverse events increased over time and peaked in 2011. During this period of time, there was significant change in practice strategies including enterprise application of intensity modulation and the application of image guidance into daily therapy. About 50.8% of adverse events involved external therapy, 24.9% of events involved brachytherapy, 20.9% were mechanical, and 20.4% involved user error. While a department will perform 100 times more teletherapy treatments than brachytherapy applications, it was interesting to note that brachytherapy adverse events were only half of those reported for teletherapy, therefore potentially more prone to misadministration. Brachytherapy is done less often, and accordingly departmental processes may not be repeated frequently enough for flawless reproducibility and execution of care. Our department is responsible for more than 50,000 external treatments every year and each individual treatment and brachytherapy application must be correct. Injuries can be imposed by diagnostic X-ray equipment especially in situations requiring interventional radiology and the use of fluoroscopy. The radiation dose cannot be extracted once delivered and the injuries imposed often have no cure [6, 7, 9, 13, 14].
\nIn these circumstances, injuries imposed are related to strength of the radiation source and distance to the source of radiation. Thermal and mechanical injuries are immediately life-threatening. Within 15 minutes of exposure, victims exposed to high dose radiation can experience symptoms associated with the event. These symptoms are manifest with high exposure by neuromuscular changes and gastrointestinal effects. At very low-level exposure, the victim may appear well; however, gastrointestinal and bone marrow symptoms may become more visible in the upcoming month post exposure. Intermediate dose exposure results in upper abdominal symptoms and lassitude seen within hours of the exposure. High dose exposure results in more extreme symptoms including rapid fluid loss and hypotension associated with more pronounced neuromuscular symptoms. Often normal tissue sequelae associated with exposure can be divided into acute injury, sub-acute injury, and chronic injury. Unintentional exposure requires evaluation by a trained group of experts who can assess both injury to the victim and risk to others with continued exposure of radioactive sources either on or inhaled/ingested by the victim. The initial screening of victims requires evaluation by trained radiation safety officers and members of emergency services who can begin to apply best supportive care. In the initial phase of the evaluation, it is important to ascertain as accurate assessment of dose exposure as possible. Lymphocyte counts due to intermitotic death and chromosomal damage assessment can be qualitative surrogates for exposure in the early phase of response assessment. Healthcare workers will likely be monitored for exposure; however, the general public will not be monitored, therefore involving experts in radiation exposure early in response assessment is essential to mission in order to appropriately define the extent of the damage and risk of injury [7, 9, 15].
\nAcute injury occurs within 90 days of exposure, sub-acute injury occurs from 90 days to 2 years after exposure, and chronic injury occurs 2 years after exposure. All organ systems are affected by radiation exposure. At very high exposures of 10 Gy, death will occur within 24–48 hours due to unrelenting swelling within the central nervous system which compromises all neural processes. At exposure of 5–10 Gy, death will occur within 1–2 weeks due to de-population of gastrointestinal stem cells and bone marrow progenitors. Profound and uncontrollable fluid losses compounded by infection are the cause of death. Victims have survived exposures to this level if they can afford maximal supportive care with fluid replacement and bone marrow support. The term LD 50/30 is a term initially used in pharmacology to determine lethal dose (LD) in 50% of the population within 30 days. Historically, the LD 50/30 for radiation exposure was believed to be 2 Gy; however, with modern support services it is believed that this can be increased to 5 Gy.
\nIf the exposure is determined to be at or below 5 Gy, most experts recommend no immediate intervention other than best supportive care and symptom management. The victim will need to be carefully monitored for manifestations of acute and sub-acute injury as well as chronic events that can appear at any point in later life including the development of malignancy. If the exposure is determined to be greater than 5 Gy, then death by hematopoietic syndrome including loss of bone marrow progenitors becomes a visible concern. Intervention with barrier nursing and appropriate blood product support is needed to move the victim through this phase into recovery. Recent nuclear accidents have suggested that infection control and vigorous supportive care may help victims survive an exposure dose of up to 7 Gy. The role of bone marrow transplantation in this effort remains to be established. It is likely of benefit in selected patients [15, 16, 17].
\nSince the development of nuclear weapons and need for response metrics to injury, there is been a scientific interest in identifying compounds that can protect normal tissue from the effects of radiation exposure. Protectors are given either prior to or immediately thereafter exposure. Mitigators are compounds given after exposure to influence and diminish the impact of the exposure to normal tissue. Therapeutic compounds are applied when the event has occurred. After WWII, it has been known that sulfhydryl groups can function as radiation protectors with the simplest compound being cysteine which contains a natural amino acid. Sulfhydryl groups are toxic which can be decreased by the addition of a phosphate group. Once the compound enters the cell, the phosphate group is released, and the sulfhydryl group becomes a free radical scavenger. Sulfhydryl groups have been shown to protect mice from lethal doses of total body radiation. The only compound approved by the US Food and Drug Administration is amifostine (WR-2721). It is sold as ethyol and has been used to prevent xerostomia in patients treated with radiation therapy for head and neck malignancies. In clinical trials, the use of the compound has been shown to improve quality of life scores for patients undergoing radiation therapy. It has also been used to protect other mucosal surfaces (rectum) and pulmonary parenchyma in patients undergoing total body radiation therapy in preparation for bone marrow transplant. To date, there has been no defined tumor protective effect assigned to amifostine. There are complexities to outpatient clinical application which can be manifested as hypotension and nausea, therefore patients need to be carefully monitored both before and after administration. It is unusual in clinical practice for patients to receive every assigned dose each day. The success is well documented; however, with improvements in radiation dose delivery across salivary tissue, amifostine is not as commonly used in clinical practice as it was a decade earlier. Citron and colleagues have identified nitroxides as agents for protection. These function as well through a free radical scavenger mechanism. Superoxide dismutase (SOD) compounds with gene therapy applications have also been explored. The gene therapy vector has been used in animal models to enhance intracellular accumulation of SOD with SOD functioning as a free radical scavenger [18, 19, 20, 21].
\nMitigators are compounds that potentially limit damage of radiation exposure once the event has occurred without clinical manifestation of injury. These compounds influence the metabolic cascade of events that occur post exposure. These compounds include those that can stimulate bone marrow and dermal progenitors. These include granulocyte stimulating growth factor (G-CSF) and keratinocyte growth factor (KGF). KGF also appears to influence the recovery of mucosal surfaces as well as improve dermal integrity. Mitigators of late toxicity center around limiting fibrosis and the primary target is transforming growth factor beta (TGF beta) and interruption of the signaling pathway that promotes expression. Investigators at the University of Massachusetts have evaluated the use of interleukin 1 alpha to limit neutrophil infiltration into the site of radiation injury to limit the extent of injury in damaged dermal tissue. Knockout mice deficient in IL-1 alpha demonstrated both decreased dermal injury to radiation and more rapid time to repair injury. In another series of experiments, investigators at the University of Massachusetts studied optical imaging as a tool to evaluate radiation injury and determine if changes in metrics associated with oxygenation and deoxygenation can be related to dose. Optical imaging demonstrated that changes in dermal tissue associated with radiation within 12 hours of exposure and imaging defined consistent metrics for acute and chronic injury. In a separate patient breast cancer treatment protocol optical imaging successfully defined radiation dose and dose asymmetry (hot spots) in patients undergoing serial imaging during breast cancer radiation therapy. Chronic changes were likewise well defined on images obtained post treatment [18, 22, 23].
\nWith increased risk of nuclear weapons and exposure to radiation through accident and future air/space travel, it is of increasing importance that emergency services become more familiar with the management of radiation exposure and injury. Radiation experts and safety officers likewise need to be aware and available to support colleagues in emergency services to optimize care for those affected by unintended exposure in time of crisis. There have been numerous incidents of unintended radiation exposure with victims exposed to both partial and total body X-ray. The Medical Science Division of the Oak Ridge Institute for Science and Education operates a Radiation Emergency Assistance Center for the US Department of Energy. The center is a 24-hour consultation service with both medical and health physics support for issues associated with radiation and X-ray exposure. The resources are comprehensive and include expertise for dose assessment, computation of dose from radionucleotides, and laboratory support. The 24-hour emergency telephone is 865 576 3131 and the website is http://www.orau.gov/reacts [9, 13, 14, 15, 16, 24, 25].
\nThere is an increasing number of cancer survivors. It is estimated that in each primary care practice by 2025 that 20% of the panel of patients in every primary care practice will be a cancer survivor. This creates a challenge for both the primary care and oncology community as management of the normal tissue imprint of therapy on the survivor does not have clear definition as providers differ in their perceived responsibilities and expertise. Historically, the focus of cancer management was driven to tumor control as a sole endpoint. Today, success brings new challenges. With survivorship improving, more patients now live in symbiosis with the known and unknown sequelae of management. Accordingly, cancer survivorship is beginning to mature as a sub-specialty service defined in oncology and executed through primary care. Gaps in both anticipation of injury and responsibility of management often are initially recognized in crisis by emergency services and often are not easily recognized as sequela of management. Unfortunately, electronic medical records are often insufficient in providing necessary information to facilitate problem solving and management. Most radiation therapy equipment and radiation therapy planning volumetric archives reside in proprietary software systems that are used to operate and validate daily treatment operations. Commercial electronic record systems do not have access to this information as the information in radiation oncology resides in proprietary systems. Although interfaces can be built to facilitate note transfer and medical billing documentation, in evaluation of a patient, the volumetric imaging, and radiation dose information is an essential aspect of problem solving in the emergency environment. For example, in the cancer survivor being evaluated for new onset chest pain, it is essential that dose/volume relationships to cardiac subsegments be available for review for analysis of risk assessment. The evolving field of oncocardiology requires an accurate record of radiation dose volume analysis to specific subsegments including pericardium, vessels, myocardium, cardiac valves, and the electrical conducting system. Each area can be affected by specific dose volume review and this information becomes essential for evaluation of the modern patient. Radiation is not a drug and has specific residual fingerprints on the area treated. Modern management of the cancer survivor requires comprehensive understanding of the impact of treatment on normal tissue by those who evaluate the patient after treatment is completed. The imposition of therapy on normal tissue lasts for the lifetime of the patient, therefore information on treatment needs to be available and in an easily retrievable format for all providers. In the next section, we will evaluate injury to tissue that is both acute and chronic. Acute effects of radiation exposure affect cells of rapid self-renewal potential such as skin, bone marrow, and gastrointestinal progenitors. Every organ system can manifest a late effect from radiation exposure [9, 13, 14, 24, 25, 26].
\nSkin is the visible site of acute reactions to X-ray and harbors chronic changes from therapy. Dermal stem cells reside at the basement membrane of the epidermis and the self-renewal process for the epidermis is 3 weeks in tissues that are uninjured. Prior to the use of linear accelerators for patient care, diagnostic X-ray equipment was used to treat patients for malignancies. This resulted in a much higher dose to superficial tissues including skin. Both acute and late effects of radiation therapy are influenced by daily dose and fractionation. In this circumstance, the skin would receive significantly high dose to skin surfaces relative to target. This has importance because fluoroscopy used in interventional radiology and cardiology can deliver exceptionally high doses to skin surfaces, especially in procedures that are highly complicated. Patients would unintentionally receive higher daily dose and accordingly, dermal sequela of management was and still can be highly visible and a significant problem. Modern linear accelerator equipment delivers dose below the skin surface, therefore skin sequelae with traditional treatment fractionation models are less visible in the modern world. However, from an emergency services perspective, radiation beams resonate on dermal surfaces in skin folds and intertriginous regions. These include skin folds in the breast and regional lymph node regions and inguinal/gluteal regions of patients treated for pelvic and anal malignancies. Dose to these areas is higher daily, therefore may have desquamation, both moist and dry, as a consequence of management. Uninformed providers refer to this issue as a “burn”. This is inaccurate. Daily treatment limits the self-renewal capacity of stem cells and injury to the basement membrane exposes the dermis to air with resultant moist changes. Although this can be a future site of infection, conservative treatment measures uniformly outpace any barrier application applied in thermal injury, therefore symptom management is often the best approach in this situation. With interest in compressed fractionation schedules for selected patients, the degree of injury during the acute management phase may be more pronounced, therefore from an emergency services perspective, it is important to ask what for the daily dose, not just whether the patient has been treated. The skin is often hyperpigmented during this phase of treatment. Chronic changes appear as hypopigmentation and thinning of dermal tissue associated with fragments of visible surface blood vessels known as telangiectasia. In the chronic phase, the skin is functional; however, if injured, repair may be more protracted. Modern intensity modulation techniques can limit both the extent and volume of radiation dose asymmetry, thus ameliorating the extent of acute and chronic dermal injury for modern patients. It is also to recognize recall of injury by many medications including antibiotics. Modern targeted therapies including epidermal growth factor receptor (EGFR), B-Raf Proto-Oncogene (BRAF), and mechanistic target of rapamycin (mTor) therapies also result in dermal injury and the integrated use of radiation therapy may augment the reaction, even in areas not irradiated. Radiation oncology is evaluating the use of more compressed treatment strategies for outpatient care including stereotactic therapy. There are reports of dermal injury to patients due to equipment augmenting dose to skin. Treatment planning needs to limit this risk [19, 21, 22, 23, 27, 28, 29, 30, 31, 32, 33].
\nAcute effects of radiation therapy affect marrow elements with rapid self-renewal potential. Lymphocytes die an intermitotic death, therefore can be used as a highly qualitative biomarker for radiation dose during exposure. Neutrophils self-renew on a near daily basis, therefore are highly sensitive to X-ray exposure like platelets. Red cells do not have nucleus, therefore decreased red cell count requires further evaluation to rule out a source of cell loss or limitation in production. It is interesting that the use of intensity-modulated radiation therapy (IMRT) for patients with pelvic malignancies is demonstrating an increase in issues associated with blood counts in patients treated with standard chemotherapy for gynecologic and rectal malignancies. This is due to the fact that most radiation oncologists have applied tighter bowel constraints for attenuation of small and large bowel sequelae of management. This brings dose further into pelvic marrow elements and away from bowel. Radiation oncologists must be conscientious on these points. Modern investigators are using advanced technology MRI and metabolic imaging tools to distinguish between red and yellow marrow elements and use IMRT for conformal avoidance to address this point. Prior to the use of modern tools for image guidance, radiation oncologists used more generous planning target volumes, and this likewise contributed to the problem. Pancytopenia and bone marrow aplasia and dysfunction are becoming a common consequence of therapy including secondary liquid malignancies. Often, these are first identified in the acute care setting. Bone marrow deficiencies can often take years and decades to develop as a consequence of therapy, therefore vigilance remains important in this area as part of patient management moving forward [19, 20, 21, 33].
\nThe cells that line the gastrointestinal tract have a rapid self-renewal potential with gastric lining undergoing renewal every day and the small bowel every 3 days. The mucosa is dynamic and is responsible for absorption of nutrition and water. Without mucosal lining, body fluid is readily lost and with intermediate level total body exposure, repopulation of mucosa cannot keep pace with fluid loss, hence the genesis of gastrointestinal death from exposure. Infection is also an issue as the barrier is denuded and intestinal flora autoinfect the victim. Therefore, barrier nursing, blood and fluid support are essential to survival in victims who have received an intermediate dose of X-ray. Investigators have demonstrated that bone marrow progenitors may repopulate and differentiate in the gastrointestinal system, indicating a potential benefit to bone marrow transplantation in victims of radiological exposure.
\nTherapeutic X-ray impact on the gastrointestinal tract is influenced by several factors including co-morbidities and previous surgery. Sequelae can be seen in patients who receive intermediate therapeutic dose to large segments of bowel as well as those who receive high dose to small bowel segments. Strictures are not thought to be a direct effect from treatment; however, if a bowel segment is fixed in position by adhesions, if irradiated, this segment of the GI tract can be further injured and may require surgical removal if symptoms become too demanding and life-threatening. Late effects from management include every tissue component of the gastrointestinal tract. Atrophy of mucosa exposures underlying submucosal tissues to external injury can lead to chronic infection and malabsorption with pain as nerve roots become exposed in the unprotected internal environment. Insufficiency syndromes including the exocrine pancreas are now being observed [19, 20, 21, 33].
\nWith the marked increase in viral- and diet-induced liver disease, there is a significant increase in primary hepatic malignancies. Coupled with the improved efficacy of radiation therapy for metastatic disease to the liver, hepatic and diaphragmatic injury from radiation treatment is now well described. Although hepatic parenchyma does not have a rapid self-renewal component, injury to the hepatic reticulum results in disorderly repair limiting blood flow to parenchyma. This limits filtration of both nutrients and toxins. With increased vascular stasis due to disorganized repair, veno-occlusive disease (VOD) becomes an insidious issue and serves to complicate the delivery of care. Metrics for the degree of pre-existing VOD influence the radiation therapy approach to radiosurgery for both primary and metastatic patients. This is important in assessing hepatic disease in the acute care setting. One of the more challenging issues for emergency room providers and primary healthcare delivery teams is the fact that radiation therapy volumetric objects do not reside in a standard electronic medical record (EMR). This makes communication to the patient/family as well as disease assessment problematic including the delivery of intravascular therapy. In a chaotic vascular system, one can never be certain that dose intent is dose delivered. Efforts are made with external radiation therapy to limit mean liver dose and in an otherwise healthy liver to 30 Gy to 30% volume [19, 20, 21, 33, 34, 35].
\nSimilar to the liver, the kidney is a sensitive late responding critical organ. Radiation doses greater than 20 Gy in 2 Gy fractions can result in renal damage with downstream consequence of anemia and hypertension. Although not validated through clinical trials, the tolerance dose is lower is patients who have also received chemotherapy. With advanced treatment technologies, modern radiation oncologists can optimize dose to the kidney using intensity modulation; however, even modern technologies leave a footprint which can limit future function. In comparison with siblings, cancer survivors have a higher likelihood of renal failure. We need to be aware of the tolerance dose as we design care plans with imaging [19, 21, 33].
\nSimilar to the liver and kidney, the lung is a sensitive intermediate to late responding organ. In extreme situations, radiation injury to the lung is life-threatening. The period of active inflammation generally occurs 2–6 months post completion of therapy. Fibrosis can occur years after therapy and this can create distortions in pulmonary anatomy relative for the region treated and dose delivered. During the active inflammatory period, changes consistent with inflammation are visible on thoracic imaging. Interestingly, changes on imaging are often more frequent than symptoms, nevertheless, when symptoms occur at times management is challenging. Injury outside the radiation treatment field is often ascribed to radiation therapy and often we dismiss this as an event without merit. Recent investigations have demonstrated that nitric oxide gas is produced as a by-product of treatment which may explain, in part, why changes in untreated lung can be seen. It is important for radiation therapy treatment objects be available for acute care providers. Although the most recognized metric for pulmonary injury is the volume of parenchyma receiving 20 Gy, in selected situations, the volume of parenchyma receiving 10 and 5 Gy may be of equal importance in determining root cause of pulmonary dysfunction. Oncology treatment records are important for review as chemotherapy agent, targeted therapies and immunotherapy can significantly contribute to pulmonary toxicity. Cancer survivors have a higher risk of chronic pulmonary disease compared to siblings; therefore need to be vigilant to their long-term pulmonary health [21, 33, 36].
\nAlthough historically, the heart and large vessels were thought to be a late responding tissue to injury, modern cardiovascular evaluation and imaging have demonstrated that radiation therapy has an impact on all cardiac structures including coronary arteries, valves, myocardium, and the electrical conduction system. Although efforts in planning radiation therapy now focus on cardiac avoidance and compartment dose volume analysis, there are multiple generations of patients treated with traditional technologies that may remain at higher risk for cardiovascular injury. Chemotherapy agents also contribute to this risk and targeted therapies may unintentionally add to risk. For example, breast cancer patients are often treated with Adriamycin on an adjuvant basis. This agent has an established history of cardiotoxicity. After administration of Adriamycin, the recovering myocardium expresses Her 2 Neu. Her 2 Neu positive breast cancer patients will receive Herceptin after initial chemotherapy, therefore these patients are at higher risk for cardiac injury without radiation therapy. Modern radiation technologies including optical tracking of position, breath hold, and intensity modulation contribute to decreasing mean heart dose and limit radiation dose to specific cardiac volumes including the left ventricle which is an issue for left breast patients. The field of oncocardiology is an important field of study. Cancer survivors have a higher risk of cardiovascular disease compared to siblings and introducing cardiac-oriented survivorship plans as patients complete their primary therapy needs to become the standard of care. Long-term radiation injury is noted to the microvasculature in all organ systems; however, large vessels were thought to be less susceptible to injury. However, as we move to treatments that include non-traditional fractionation protocols and overlap of previous areas of radiation therapy, evaluation of large vessels with surveillance imaging including the carotid vessels for patients treated for head and neck cancer. With more patients being retreated for secondary events, conformal avoidance to cardiovascular structures as part of primary management and avoidance of radiation dose asymmetry will be important to optimize outcome moving forward [37, 38, 39, 40, 41, 42, 43].
\nThe brain has multiple cell systems susceptible to injury uniformly viewed as late responding tissues. Necrosis can occur after radiation therapy, especially in circumstances of compressed fractionation and stereotactic radiosurgery and radiotherapy. Although highly unusual, demyelinating syndromes can occur both in the brain and spinal cord associated with both radiation dose and volume treated. Toxicity is also increased with chemotherapy agents including but not limited to Ara-C and Methotrexate, both used in multiple disease settings due to penetrance beyond the blood-brain barrier. There are injuries noted to tissues with end arterial vascular systems. The optic chiasm is susceptible to injury with radiation therapy due to the unique arterial system at doses of 54 Gy. The cochlea is susceptible to injury especially when cis-platinum is used as part of the care plan. Brachial plexus injury was described in breast cancer patients at doses of 54 Gy; however, this is an issue which identification of this dose may be inaccurate. At the time of description of the injury, radiation therapy techniques unintentionally created overlap with anterior and posterior fields under the lateral third of the clavicle where the entire nerve plexus enters the upper extremity. It is rare to see plexopathy in head and neck patients, therefore the experience with the breast cancer population and regional treatment may have related to technique rather than radiation dose. This again point to the importance of increasing the knowledge of radiation therapy in the general medical community and acute care providers [33, 44].
\nHypothyroidism is exceptionally common in patients treated with both surgery and radiation therapy to the upper thorax and neck. This can have significant health issues and is often overlooked and underappreciated in the acute care environment. The thyroid is also highly vulnerable to injury with unintended exposure and a source of secondary malignancies due to exposure. Gonadal exposure leads to both fertility issues and endocrine dysfunction, which can affect every organ system including growth and development in children. Atrophy and dysfunction of multiple organ systems is identified in patients where limitations in estrogen and testosterone function are not identified. Pituitary dysfunction is well described in multiple disease systems especially in patients treated with high retropharyngeal adenopathy or primary disease in the nasopharynx. Modern survivorship plans need to include strategies for endocrine malfunction [33, 26].
\nChildren are a highly vulnerable population. Although treated at a young age, late effects often become more visible when these cancer survivors transfer their long-term care into adult medicine. At radiation doses of 20 Gy, limitations in musculo-skeletal development are seen and at dose of 55 Gy bone necrosis can occur, especially in patients treated with chemotherapy. Exit dose from cranio-spinal radiotherapy can impose changes in cardiovascular and pulmonary health and development. Treatment for Wilms tumor makes children vulnerable to renal health problems as adults. Because these children are treated as infants and young children, even low dose therapy affects gonadal function and other gastrointestinal injuries including maldevelopment of bowel segments. With advanced imaging techniques, structures once thought immune to radiation effects now are known to be more vulnerable to injuries. Sacral insufficiency fractures are now visible at radiation doses of 50 Gy. Stereotactic body radiosurgery is now associated with injuries once thought historical in nature including rib fractures from pulmonary therapy. Often childhood patients do not have survivorship plans that can detail what is needed when they become adult patients and adult physicians need to detail a plan when caring for these patients as they become adults to provide a comprehensive survivorship plan.
\nIntentional and unintentional radiation exposure can have significant impact on normal tissue, both immediate and late. In assessing acute exposure, it is essential to determine exposure and dose. Optical imaging may be a tool moving forward which can validate computational extrapolation of dose as injury can be seen within 12 hours of exposure. Appropriate support needs to be applied to victims of acute exposure and intentional therapy needs to be mitigated by strategic planning and application of therapy. Survivorship plans for those exposed to radiation including those with unintentional exposure need to be developed. An understanding of these effects is essential for modern healthcare providers in the acute care setting [19, 20, 21, 26, 33, 45].
\nIt has been more than 100 years since the discovery of X-rays and radium. The power of radiation is significant and appropriate application of radiation has saved lives and become an extraordinary source of energy. The devastating side of radiation is equally visible. Both intentional and unintentional injury remains at significant risk in spite of a century worth of knowledge concerning radiation safety and application of safety measures. Radiation therapy and diagnostic imaging remain tools that are essential to mission for patient care, nevertheless we must remain vigilant and apply continuous process improvements in practice to ensure optimal patient care and secure safe environment. Enhanced knowledge of the impact of radiation on normal tissue is important for emergency care workers.
\nThe authors certify that there is no conflict of interest in relation to this manuscript.
The entire world population is around 7.7 billion, which is growing steadily. One of the main predicaments is the lack of quality food for human beings due to environmental biotic and abiotic problems such as weeds, pests, and diseases [1]. Over 65,000 kinds of pests are recorded, including weeds, arthropods, and fungi or are also regarded primarily as plant pathogens [2]. The recent evidence recommended that pests prompted an 8-10% loss in wheat crops, 20% in sugar, 25% in rice, 30% in pulses, 35% in oilseeds, and 50% in cotton. The estimated annual crop loss caused by pests and diseases is USD 2000 billion. Therefore, different pesticidal technologies should be extended in these circumstances, particularly in developing countries, to subdue these food predicaments [1]. For the last several years, pest management in industrialized counties has depended on the application of pesticides. Hence, the application of pesticides was raised above 1900% within the 1940s-1980s. According to a calculation, today, 2.3 billion kg of pesticides have been applied annually, making up to $ 58.5 billion of the global exchange [2, 3].
Every year, almost 25% of the world’s crop production is destroyed by pests [4]. Many types of pests including
The pesticides are divided into chemical, biological, synthetic, microbial, biopesticides, biochemical, and plant-incorporated pesticides. Chemical pesticides are delivered to plants either directly for seed treatment and weed control or indirectly through spraying the chemical on plants. Some chemical pesticides show good pesticidal activity, but they exert negative impacts both on human health and the environment; for example, methyl bromide has been reported as a good pesticide over the last 40 years against soil-borne pathogens, pests, and nematodes in many crops like tomato, melon, pepper, and strawberry. But later on, due to its ozone depletion negativity, it was banned in 2015 following the Montreal Protocol. Moreover, some other chemicals like chloropicrin and dazomet are restricted in some areas due to their concern about food safety and human health [9].
Biopesticides, often known as biological pesticides, are insecticides derived from microorganisms or natural substances. Biopesticides are divided into three categories: microbial biopesticides, botanical biopesticides, and plant-incorporated protectants [10]. As an alternative to conventional insecticidal methods, biopesticides have recently gained much attention due to their potential target specificity, fewer harmful side effects, capacity to disintegrate fast, and high efficacy. Several substances have been investigated as biopesticides in recent years, including
The nano-biopesticides have superiority over the biopesticides and conventional techniques for many reasons, including environmentally friendly behavior, desired results within a few hours after applications, biodegradability, easy delivery to plants, and release slowly from the vector [15]. Furthermore, their small size makes them an effective carrier when combined with pesticides that can easily enter the plants. Another advantage of nano-biopesticides is that they did not have an adverse effect on soil microorganisms and phototoxicity of Ag-based nano-particles was suppressed by nano-coating them with biocompatible polyvinyl pyrrole compounds [17]. The nano-biopesticides can be synthesized by following two ways: either by extracting the biological active pesticidal compound (APC) from plants and blended it with nano-particles and inserted it into a suitable polymer that acts as a supporting material, or APC secrete the metallic salt with bind with nano-particles (NPs) that hemolyze and merge into an appropriate polymer. The APC integrated with NPs and merged into a compatible vector including micelles, liposomes, nanosphere, polymer, and nanofiber. These ingredients were used as a spray to kill the insect pests for food protection [18].
The accumulative data revealed that nano-biopesticides contain secondary plant metabolites and their mediated metal oxide nanomaterials. It was found that biopesticides have gained importance over chemical pesticides during the past few decades due to their eco-friendly behavior, high efficiency, and fewer side effects. The evidence reported that recently much research had been carried out on nano-biopesticides; either pests are attaining chemical pesticide resistance, or a small number of insecticides have expired due to severe environmental and human concerns. However, this situation demands novel plant-based pesticides on the nanoscale to formulate the nano-biopesticides for pest management. Recently, different biopesticides have been reported against different pests such as
Agricultural output has been increased dramatically in the early 20th century, especially in the United States, to keep up with the rapidly growing human population. During the last century, the world’s population has tripled from 1.5 billion in 1900 to 6.1 billion in 2000. The world’s population has grown by one billion people in the past decade, and the UN predicts it could reach 9.4 to 10 billion by 2050 if current growth rates continue [22]. A lateral increase in food production was needed during the 20th century to keep up with the increase in the world population. This was accomplished via the use of fertilizers and other agricultural inputs throughout the twentieth century. Bio-fertilizers (such as guano) were first used in the late 1800s; inorganic phosphate fertilizers (such as urea) were first used in the early 1900s and have steadily gained in favor ever since [23]. Phosphates helps to increase the crop diversity and yields and aided in the unprecedented “green revolution” for agricultural productivity. This caused a tenfold increase in grain production per unit surface area of agricultural land, leading to a global food surplus [24]. An increasing global population and increased phosphate production were shown to be positively linked throughout the 20th century, with an R2 of 0.97 for the period 1900–1988 [25].
Synthetic crop preservation agents were introduced to the market in the 1940s, which increased food output. It grew from 0.2 million tons in 1950 to over 5 million tons in 2000, up from 0.2 million tons the year before. Between 1950 and 2000, pesticide production grew by about 11%, from 0.2 million tons to over 5 million tons. Crop preservation chemicals, sometimes known as pesticides, are composed of various composites, including growth regulators, neonicotinoids, organochlorines, pyrethroids, organophosphates, carbamates, and more recently, biopesticides. This wide spectrum of chemicals and insecticides has been developed throughout history to protect crops from pests and diseases. All sorts of pesticide sales grew; however, herbicides were the group that extended the most, accompanied by fungicides and insecticides. Pesticide application has suffered owing to lack of global uniformity, high cost of chemicals, human resources, and the vast diversity of pests present in each climatic or geographical area. Using FAO data, it was found that the mean pesticide application rates per hectare of arable land ranged from 6.5 to 60 kg/ha, with the greatest mean values occurring in Asia and a few South American nations. Unlike Western Europe and North America, Asia has not witnessed a rise in the usage of herbicides in both urban and agricultural areas. Compared to the widespread use of insecticides, herbicide usage in Asia has remained relatively low in recent years, according to World Bank and International Food Policy Research Institute data [26].
Throughout the twentieth century, ancient synthetic pesticides intended for agricultural pest control, such as DDT, were often used to treat human parasites and animal ticks. So, for example, DDT was designed to be used in agricultural pest control. Despite of being prohibited, it is nevertheless extensively used as a food prophylactic for various fish in South Asia, and to control home pests and malaria vectors globally, albeit seldom illegally [27]. Pesticides have been administered in agricultural settings for decades, employing techniques ranging from truck and aircraft spraying to old-fashioned field worker spraying. Studies on the effects and toxicity of manufactured chemicals on human health and well-being have shown that individuals report euphoria after pesticide application. This research included peasants, farmworkers, and their families following pesticide treatments. They previously discovered that unintentional poisoning affects about 355,000 individuals annually and is linked to high susceptibility and poor chemical management. They also discovered that increased sensitivity and poor management of hazardous substances are closely linked to such toxicities [28]. The research was conducted to assess the number of pesticides in the environment that killed various animals. Among the animals that resided there were fish, birds, bees, amphibians, and tiny mammals. It was also noted how much they were killed and how they were slaughtered [29].
Following the introduction of synthetic chemicals into the environment, it was only a short amount of time before it was thought that crop protection pesticides were causing disease both locally and internationally [26]. Many believe that sprayed on-crop DDT is deported into water bodies, quickly converted into DDE, and bio-accumulated in aquatic food systems before being reintroduced into the environment and ultimately reaching people. To manufacture endosulfan at this time, a rigorous and scientific decision-making procedure is undertaken. Additionally, this strategy includes scientific research to enhance food production, food safety, and environmental security in addition to the other objectives listed above [26].
Common use of synthetic pesticides inhibits the development of plant pathogen strains resistant to these chemicals, causing the reemergence of illnesses in the environment. Pesticides are being used more often by farmers, which is good [30]. Synthetic pesticides include active ingredients that are absorbed and retained by plants after application. People suffer chronic health issues due to the high concentration of harmful chemical deposits in these crops cultivated for human use [31]. Synthetic pesticides include active ingredients that are absorbed and retained by plants after application. People are suffering from chronic health issues due to the high concentration of harmful chemical deposits in these crops cultivated for human use [32].
The need for biopesticides has been increased significantly in recent years, particularly in developing countries, due to restrictions placed on the use of some synthetic pesticides, such as organophthaloids, organochlorines, carbamates, and organophosphates, among other things. Synthetic pesticides are not only harmful to pests and diseases at the time of application, but they also have the potential to contaminate plant crops, posing a threat to human health, animal welfare, and environmental health. Synthetic pesticides are used to control pests and diseases in agriculture. In agriculture, synthetic pesticides are used to manage pests and illnesses that are introduced via the soil. As reported by the Environmental Protection Agency, synthetic pesticides are also harmful to both people and animals. They are also bad for the health of the ecosystem. When it comes to biochemistry, chemical pesticides are characterized by alterations in the signaling system, inhibition of enzymes, pH shifts, disruption of electrolytic balance, osmotic and membrane breakdown, pH gradients across membranes, and other characteristics. They also generate free radicals and other toxic compounds, which have the potential to damage proteins and DNA, as well as cause tissue degeneration, among other undesirable effects [14]. A wide range of diseases has been linked to the use of synthetic pesticides, including Parkinson’s disease and neurotoxicity, type 2 diabetes, endocrine disruption, many cancers, and obesity, among others. Parkinson’s disease is the most well-known of these disorders. It has been shown that the use of synthetic pesticides is linked with the development of these diseases, which may be due in part to the mechanisms of action of these chemicals, as well as the increasing exposure of individuals to these chemicals over time [33, 34, 35]. Despite the fact that it is regrettable, the majority of pesticides now in use are being phased out at a rapid rate, which is a good trend in the industry. On the other hand, pesticides that are still in use continue to accumulate in the human body with every meal that is eaten. In addition, employees who have been exposed to pesticides have been observed to get drunk as a result of the pesticides they have been exposed to over the course of their shift [36]. Natural pesticides offer many benefits over synthetic pesticides, the most significant of which is that they are less harmful to the environment and human health. However, this does not mean that they should be utilized recklessly or without consideration for the repercussions of their actions. Even if certain products have been authorized for use as biopesticides, it is conceivable that they may cause health issues among members of the general population. Large quantities of copper, which is an essential nutrient in the diets of both mammals and plants, have the potential to be poisonous to both humans and animals and hazardous to aquatic life if eaten over an extended period of time. There is also concern about toxic plant species, microalgae, and algae such as
As the name implies, biopesticides are pesticides that include active ingredients formed by microorganisms or natural materials rather than synthetic chemicals. They are used to control insects in a variety of circumstances and are referred to as “biopesticides.” Pesticides derived from plants are divided into three categories: (a) microbial biopesticides, which are microorganisms that are effective against diseases and insects; (b) botanical biopesticides; and (c) plant-incorporated protectants. Microbial biopesticides are microorganisms that are effective against diseases and insects. Microbial biopesticides are microorganisms that have been shown to be efficient against many illnesses and insects in the field. A microbial biopesticide is a bacterium that is effective against a wide range of diseases and insect species, including fungi [10].
The presence of fungus is associated with insect damage.
Non-toxic biochemical pesticides are natural insecticides produced by animals, plants, and insects. They do not damage the creatures that produce them. They are employed to manage pests without killing them. These chemicals may assist in growth and development by attracting or repelling pests (pheromones) and acting as plant growth regulators (PGR). It’s difficult to tell whether a biopesticide is hazardous since so few countries have committees to test metabolites.
As a consequence, evaluating a biopesticide’s safety is difficult [43]. Since their discovery, Auxin-type PGRs have been hailed as one of the most effective herbicides and biological control agents on the market. And for a good reason. It is generally recognized as one of the most efficient herbicides and biological control agents on the market today. Consider the difference in action selectivity between marijuana and PGR. Marijuana has a more selective effect, perhaps due to its fast detoxification process. Low concentrations of these chemicals promote cell elongation, biofertilizer activity, cell division, and cell growth. Dense doses cause weeds to get intoxicated and exhibit developmental abnormalities such as impaired respiration, carbon absorption, and transpiration. In the end, these anomalies harm weeds’ circulatory systems and membranes, leading to their demise [14].
When applied to crops, pesticides (chemical compounds and plant extracts) are used to prevent the growth of pests (including insects) of various types. Pesticides are used to limit, halt, or otherwise manage pests of many kinds, including insects. Some ways in which plant security may be achieved include the utilization of a variety of secondary metabolites produced from plant sources such as essential oils, phenolics, and terpenes, among other things [44]. The non-persistency of essential oils in the environment, along with the fact that they are non-toxic to animals, has led to their being widely regarded as one of the most efficient agricultural pesticides presently available. As acaricides and insecticides, these compounds have the potential to be utilized in the environment, where they may also be used to inhibit the growth of fungus and bacteria. When essential oils are applied to plant cultures, the anti-oxidant properties of the oils protect the plants from pro-oxidants found in proteins and DNA, which cause cytotoxicity, the formation of reactive oxygen species, as well as the breakdown of cell membranes and organelles in the microorganisms that infect the plants [45]. However, the effectiveness of a biological pesticide can be affected by several factors, including the mist of the substance harvested, the method of extraction used to obtain this type of biopesticide, and the age of the plant from which the oil will be collected. The toxicity of a biological pesticide can also be affected by several factors, including the phenological age of the plant from which the oil will be collected. Although agricultural pesticides have many advantages, their use has been restricted for a variety of reasons, including their inability to maintain stability over time, the complexity of the extracted combination, extraction techniques, or formulation of the active component, as well as difficulties encountered during the purification process [46].
There are a number of plants that have been recognized as intrinsic sources of agricultural pesticides, as described in Table 1. The pests that are targeted by the insecticides contained in those plants are also included in the table. The ethanolic plant extracts of ginger (
Plant | Host | Target pest | Reference |
---|---|---|---|
Human and animal sp., | [47, 48, 49] | ||
[50, 51, 52] | |||
Human and animals sp., | [53, 54] | ||
[55, 56, 57] | |||
Zea mays, | [58, 59] | ||
Human sp., Animal sp. | [60, 61] | ||
[62, 63] |
The potential plant compounds as botanical pesticides and respective target pests.
Because of a number of factors, biopesticides are not widely utilized as a pest and disease management alternative, despite the fact that they offer many benefits, including the preservation of the environment and the safety of food for human consumption. For the component compounds to be effective in field settings, high dosages of the compounds are required [67]. The emerging evidence revealed that the biopesticides isolated from plants have to face more challenges regarding activity because they are extracted from plants that also contain several other bioactive compounds that could change their chemical properties. Moreover, the utilization of organic compounds as a solvent for the extraction of pesticides is involved in environmental pollution through their disposal. It was also found that biopesticides have a short shelf life that is associated with a high biodegradability rate. In addition to botanical pesticides, microbial pesticides could prove to be better pesticides for a limited type of pest in the field, but they only showed activity against one type of pest, that is one of the biggest disadvantages of microbial pesticides. Furthermore, other environmental factors such as desiccation, heat, light, and UV reduce the activity of microbial pesticides, resulting in continuous crop destruction [68].
The number of bioactive compounds present in plants and the kind of habitat in which they develop is influenced by the environment in which they are grown. Furthermore, the diversity of plants and their differences have an impact on the amount and kind of active chemicals contained in them, resulting in differences in how they respond to illnesses [69]. The quality of plant extracts, on the other hand, varies depending on the extraction method employed. It may be difficult to get the appropriate active and inert components ratios during the formulation process in certain instances. Aside from that, there are no established processes for preparation or assessment of efficacy, especially in field situations when time is of the essence [70]. However, although
From 1959 to 1960, developments in nanotechnology and nanoscience have been made to explore the synthesis and role of nano-particles prior to using them for different biomedical applications. Norio Taniguchi, a professor at Tokyo University of Science, made several successful attempts to synthesize nanometer-sized semiconductors in 1974. Later, it laid the foundation for research to perform experimentation on different types of nano-particles and nanocomposites. Nano-particles are found naturally in plants such as algae in the form of superoxide nano-particles and insects in the form of nanostructures. Nano-particles can be synthesized through physical, chemical, and biological methods [72].
Nano-particles fabricated via physical, chemical, and biological methods are classified by their chemical composition, Nanoparticles in the form of metals such as Cu, Fe, Zinc, Au and in the form of oxides such as ZnO, CuO, AlO, in the form of semiconductors such as ZnS, CdS, ZnSe, carbon-based nano-particles in the form of graphene, diamond, fullerenes, in the form of silicates such as nano clays, in the form of nano-particles based on dendrite with long chains of fibers [73]. Different nano-particles are divided into different dimensions on the basis of their application in different biomaterials. The one-dimensional object possesses thin layers and fine surfaces. Second-dimensional possesses the wires with excellent flexibility and long tubes. Third-dimensional materials can be synthesized from metal oxides through physical and biological methods. These dimensions of the nano-particles have different applications in the fields of agriculture, medical, pharmaceuticals, pest management, and different industrial sectors [72].
Nano-biopesticides are attractive due to their tiny size, high surface-area-to-volume ratio, stability, enhanced efficacy, better solubility, mobility, and decreased toxicity. Nano-biopesticides are also suggested because of their low toxicity (see Figure 1). Chemical pesticides are directly applied to plants can possess toxins released by air into the food chain and cause environmental issues. To control these issues, pesticides with formulations of nano-particles such as micelles and nanocomposites reduce the chances of both environmental and health issues. Similarly, clay-based nanotubes deliver pesticides to control pests [75].
The importance of nanotechnology for the formulation of nano-based biopesticides. This figure is reproduced from Lade et al. [
Like nano-fertilizers, nano-biopesticides are contained in carriers that enable for regulated release of active ingredients to accomplish desired effects in a given environment. Stiffness and penetrability are two properties enhanced by adding nano-biopesticides to biopolymers. Crystallinity, thermal stability, solubility, and biodegradability are also enhanced [76, 77]. When nanomaterials were applied to the soils, nano-biopesticides containing nanomaterials resulted in the growth of mutualistic microorganisms that promote the pants’ activities [17]. Sometimes, toxicity can be induced by coatings of silver-based nano-particles that could be reversed by biocompatible coatings, thus increasing the chances of seed germination in plants. Recently, nano-emulsions, nano-encapsulates, nanocontainers, and nano-cages have been reported as some nano-pesticide delivery techniques with different functionalities for plant protection [77].
Further research shows that cationic polymers may bind to polyanionic surfaces of bacteria, disrupt cell membranes, and kill pests. In agriculture, plants may be treated with biopesticides, such as nano-biopesticides, which can decrease microbial resistance, whereas chemicals applied directly to plants are unable to suppress a wide range of bacterial growth. Tertiary ammonium groups may be found in nano-particles as lengthy amino acid chains. Depending on their structure, these groups may attack various pests and illnesses, including bacteria. Because of their high activity in a wide variety of environmental and chemical conditions, polymers with quaternary ammonium groups in their chains are widely used [78]. Many polymers with this characteristic have been found and researched throughout time. For example, amphiphilic copolymers, functionalized cationic polycarbonates, poly(amidoamines), polyethylenimine, poly(methyl methacrylates), amino celluloses and chlorinated cellulose acetates are now available [78, 79, 80].
Essential oils (EOs) are highly volatile secondary metabolites found in many higher plants and flowers and certain fruits and vegetables. In addition to their traditional uses in medicine and cosmetics, a new study indicates they represent a major natural source of ecologically friendly pesticides. Essential oils are often used to treat gardening pants to keep insects and bees out of the garden. Invertebrates become neurotoxic when their nervous systems are suppressed of GABA and acetylcholine esterase (ACE) [81]. This 2007 research evaluated the anti-pest effects of plant extracts, essential oils, their purified components, and plant-based nano-formulations, as well as their modes of action. Temperature, light, and oxygen supply all have an impact on the EO’s integrity. Researchers found that encapsulating flaxseed in gelatin and Arabic capsules may improve effectiveness by up to 84 percent, preventing the production of certain oxidants that stimulate the growth of some insects [82]. Sagiri
A variety of plants with nano-emulsions of ECs can be used to control the larval infections of different insects. These plants are
Nano-biopesticides can be tested against a specific pest in order to check their efficiency before applying them in different crops. Nano-biopesticides can be synthesized through the active pesticidal compounds and combinations of different nanomaterials such as zinc oxides, silver oxides, and aluminum oxides. [89]. The toxicity of nano-biopesticides can be measured through the minimum inhibitory concentration that employs the agar well diffusion method. Filter paper is usually coated with the outer surface of nano-biopesticides, and oral feeding directly applies to the target pest. The concentration of dead and alive pests can be precisely measured after 40 days of feeding [90].
The pupicidal activity of nano-biopesticides is helpful in preventing the attack of pupae of different insect groups. It can be measured after applying the nano-biopesticides applied to the pupae of the target insects. This activity strongly measures the mortality rate after one day, which depends on the concentrations of nano-biopesticides. The work of Sivapriyajothi
The larvicidal activity of nano-biopesticides can be measured by the leaf disc method by introducing them into the leaf, and concentrations of larvae can be determined after 96 hours. Some plants show larvicidal activity, such as leaf extract of
The anti-feeding activity of nano-biopesticides can be measured by applying them to the leaf disc of pest food. The one-third-instar larva is introduced to the leaf, and the condemnations of leaf eaten by larvae can be measured every 24 hours. Anti-feeding activity has been observed about 92.4% in
Nano-biopesticides can be applied to plants in the right concentration in order to protect them from seasonal diseases. These concentrations (LC 50 and LC 90) aid in the identification of specific larvae, insets, and bee attacks. Nano-biopesticides are also applied in changing environments such as temperatures, humidity, and environmental stresses. In these conditions, nano-biopesticides are directly applied in the form of sprays to protect the plants from pest attacks. Therefore, the use of nano-biopesticides has become the most effective method in controlling the attack of animal vectors and disease-transmitting pests.
Pests of stored grains are among the most difficult to manage in an agricultural system because of their large size [94]. Recently, it has been shown that alumina, silica, SiO2, zinc, and silver nano-particles have a substantial anti-pest effect against a range of pests when combined with other chemicals [95]. According to the researchers, when sprayed on plants or crops, nano-emulsions have been shown to be efficient in deterring the attack of attack insects that cause harm to grains that have been stored for extended periods of time. The researchers discovered that nano-biopesticide emulsions effectively prevented the spread of the
Creating nanosuspensions may be accomplished using two distinct approaches, which are referred to as the bottom-up approach and top-down technology. The bottom-up approach is the more traditional way of creating nanosuspensions. In order to achieve top-down drug particle reduction, a number of techniques such as high-pressure homogenization and media milling are used. Following the bottom-up approach, pesticides (that are to be converted into nanosuspension) are solubilized in a suitable organic solvent and precipitated with the aid of a suitable stabilizer that has been dissolved in an antisolvent as a result of this solubilization and precipitation (often water). Methods such as precipitation, microemulsion, and melt emulsification, to name a few, are among the most often used in this method, and they are described in more detail below [98, 99]. The following are some of the most important methods for the production of nanosuspensions, which are described below.
The advantage of this method is the production of pesticides that are poorly soluble in water via the use of high-pressure homogenization. Successful completion of this procedure depends on completing three essential steps: In the first stage, a finely powdered medication is dispersed in a suitable stabilizer solution, resulting in a pre-suspension that is then subjected to further treatment after being stabilized. The pre-suspension is homogenized at a low pressure throughout the following procedure to guarantee consistency. Finally, but certainly not least, it is homogenized at high pressure for about 10 to 25 cycles, or until the desired size is achieved. Despite this, this method is only suitable for the production of highly concentrated nanosuspension formulations rather than diluted nanosuspension formulations since the pesticides must be micronized before they can be delivered to the field [99, 100].
It has been shown that when exposed to high temperatures, precipitated plant extract nano-particles may crystallize and transform into microparticles. Greater energy pressures are thus required to homogenize them in order to avoid the development of microparticles. Because of their crystalline structure, these particles, which may be completely amorphous, completely crystalline, or slightly amorphous in nature, may cause bioavailability and long-term stability problems when used in pesticide formulations. It is necessary to homogenize the precipitated nanosuspension before it can be used to maintain the particle size achieved during precipitation. This method also has the benefit of being able to be used to produce pesticides that have low solubility in both organic and aqueous solutions, which is advantageous in both cases [101].
In this method, the plant extracts are exposed to an ultra-fine grinding medium, which results in the production of extract particles of a nanometer or smaller diameter. As a consequence of the contact of extracted particles with the milling medium, higher energy shear forces are produced throughout the milling process. This provides the required energy input to induce the microparticles to burst into nano-particles during the operation. For many days, milling material, which may consist of extract, a stabilizer, and water or another appropriate buffer, is rotated at a faster speed than the rest of the milling chamber and spun at a slower speed than the rest of the milling chamber [102].
When the plant extract is dissolved in an organic solvent of choice, it is dried, which is referred to as precipitation. The surfactant is mixed with water (antisolvent), which also includes surfactant, to create a cohesive combination in order to achieve cohesiveness in the final organic phase of the reaction (aqueous phase). It is feasible to oversaturate the plant extract by adding the prepared organic phase to the aqueous phase in a fast manner (organic solvent to antisolvent). As a consequence, ultrafine particles are produced in large quantities (crystalline or amorphous). This process involves, among other things, the creation of nuclei as well as the growth of crystals, depending on the temperature. A high nucleation rate combined with a slow crystal development rate is required to do this since a stable solution with a smaller particle size than is presently accessible cannot be achieved without doing so [103].
Any nano-effective formulation in real-world applications depends on effective distribution. Environmentally friendly use of water, fertilizers, and pesticides is possible using nano-sensors and smart delivery systems (see Figure 2). Using satellite pictures of their fields in combination may allow farm managers to identify agricultural pests and collect evidence of stress caused by high heat, floods, or drought. Nanomaterials and GPS will be combined with satellite images of fields to produce a more realistic environmental model. Using this technology, farmers can now change agricultural inputs automatically. So, nano-sensors in the field may be able to detect plant viruses and soil nutrients, allowing for more precise crop management. Pesticide use and contamination will be minimized when slow-release nano-biopesticides contained in nano-particles are delivered to their targets [105]. Another alternative is to utilize a nano-barcode, a new technology that may be used to check the quality of agricultural products. Cornell University researchers used supermarket barcodes to create a low-cost, efficient, quick, and simple method for decoding and detecting diseases and illnesses. The technique was developed using grocery barcodes. These tiny probes or nano-barcodes may be scanned with a microscope using self-folding branching DNA constructs. It is feasible to detect a disease biomarker on agricultural goods or on the farm using a fluorescent color ratio. Because nano-barcodes and pathogen biomarkers are so compatible, any fluorescent-based device capable of detecting infection or illness should be able to recognize them. This continuing study’s goal is to create a portable on-site detector that non-experts may utilize [106]. Auxins, plant hormones, are important in root development and seedling establishment in both young and mature plants. Purdue University researchers have created an auxin-detecting nano-sensor that may be used to detect it in the environment. The interaction of auxin with biosensors produces a signal that can be monitored and used to detect the amount of auxin present at different locations along the root’s length. Another method is to use mathematics to see whether neighboring cells absorb or release auxin at different rates. This advances auxin research by allowing scientists to better understand how plant roots adapt to their surroundings. This study’s findings may help improve agricultural research in the future [107].
The schematic diagram of delivery of nano-biopesticides to crop for pest management. This figure is reproduced from Lade and Gogle [
Using a micro- or nano-emulsion may enhance nano-biopesticide solubility, kinetic stability, optical transparency, and bioavailability while decreasing emulsion size and viscosity [108]. Despite not being intended for agricultural usage, a nano-permethrin formulation free of artificial polymers and stabilized with natural plant surfactants was shown to be an efficient larvicide. Developing nano-particles that act as a coating or protective layer for conventional nano-biopesticides and fertilizers may also be a future research topic. According to the National Science Foundation, nano-clay materials provide high aspect ratio interaction surfaces for encapsulating “agrochemicals such as fertilizers, plant growth stimulants, and insecticides” [109]. Incorporating silver nano-particles into electrospun polyacrylonitrile fibers is intriguing due to the possible antibacterial characteristics. This method may be used to entrap an active biopesticide or a nano-biopesticide for use in soil-applied pesticides or insecticides. To kill the soilborne bug, an electrospun nanofibrous mat loaded with nano-biopesticides is electrospun into the soil and subsequently removed [110].
Biopesticides have a variety of distinct modes of action that are distinct from one another and may be used in various settings, including agriculture. Through a variety of mechanisms, including parasitism, antibiosis, and predation, among others, microorganisms generate pesticides that are harmful to humans and animals. Botanical pesticides have been shown to be very effective since they kill insects while also interfering with the development of diseases. Prey is killed as a result of the attack by being parasitized or poisoned, which leads them to die as a result of the attack. Pests are attracted to the treatment area as a consequence of the application of the treatment, which results in the pests being killed or sterilized (see Figure 3). Extracts from plants belonging to the Asteraceae family have been reported to inhibit hyphal growth and induce structural modifications in the mycelia of plant pathogenic fungi [112].
The general mechanism of action of nano-biopesticides for pest insect management. This figure is reproduced from Mossa, [
There are different types of biopesticides, including sabadilla, pyrethrum, azadirachtin, and fluoroacetate that show different mechanisms of action against pests. For example, the alkaloid toxin of sabadilla significantly caused the loss of nerve cell membrane mechanism by affecting the nerve cell membrane of insects. It was found that sabadilla could kill most insects immediately after its use, but a few could survive up to few days in a state of paralysis before dying [115]. In addition, the emerging evidence revealed that a low dose of pyrethrins significantly causes the immediate death of insects. For humans and warm-blooded animals, pyrethrins are not toxic. Allergic responses to humans, however, are frequent. It may cause a rash, and inhaling the dust can lead to headaches and illness. By altering the process of sodium and potassium ion exchanges in insect nerve fibers, pyrethrins exert their deadly effects by inhibiting the normal transmission of nerve impulses. The insecticides containing pyrethrin work very quickly and produce paralysis in the insects very quickly. But many insects can swiftly metabolize (break down) pyrethrins in spite of their acute toxicity. However, piperonyl butoxide (PBO) and pyrethrin could be used as combined therapy against these insects [116].
A recently reported study revealed that administration of azadirachtin to third instar larvae significantly reduces food consumption compared to control [117]. But, its antifeedant activity surely depends on the insect species and dose concentration [118]. It was reported that the inhibition of feeding behaviors after azadirachtin dose from stimulation of deterrent receptors was coupled with sugar receptors that lead to food restriction, starvation, and bad nutrition [119]. Recently, various studies have demonstrated the weight loss behavior of azadirachtin in different insects, including
Nano-biopesticides are eco-friendly, possess biodegradation properties, and are transported to the different parts of plants. Due to their bioavailability in the plant system, they are helpful in understanding the interactions and behavior of different pests that tack on crops. Spraying silver nano-particles with combinations of aloe vera extract and silver nitrate is helpful to control the growth of pests such as
Nano-biopesticides are biodegradable and transported to the different tissues of pants. Some studies have shown that soil applications of nano-biopesticides under optimum conditions are helpful for the degradation of toxic metabolites that are produced in plants. These metabolites cause the accumulation of toxic metals. It leads to an increase in the chances of death of plant tissues. On the other hand, traditionally used chemicals also increase the chances of death of plant tissues due to cellular toxicity in some cells. Therefore, the use of nano-biopesticides in environmental applications is much more reliable than other chemical compounds [125]. Nano-biopesticides reach the soil by activating the microbial activities that increase the chances of useful bacterial activities in plants such as mycorrhizal association.
Nano-biopesticides play an important role in maintaining environmental sustainability by replacing traditionally used chemicals in the form of sprays. The use of nano-biopesticides to control the pests also maintains the ecological chain. Nano-biopesticides for land conservation ensure the maximum yields and maintain the farming system. So, nano-biopesticides are also helpful for improving soil quality and increasing food yields under different cultivations. Other applications are found in crop protection by controlling pests and other animals such as bees and birds through sustainable development [126, 127]. The representation of the process of formulation of nano-biopesticides to fully commercialization is presented in Figure 4.
The general process of formulation of nano-fertilizer to commercialization. This figure is reproduced from Lengai and Muthomi [
Nano-biopesticides are used in the control of pests in order to prevent their action in agriculture sectors. These bio-pesticides will be helpful in targeting the different pests in more effective ways by reducing the chemical compounds in order to make profitable and environmentally friendly production. Due to unclear molecular mechanisms and sites of action to the target of the action, research progress for pest control in agriculture is slow [129]. Recent studies show that applications of nano-biopesticides are effective in controlling pests by replacing the traditionally used chemical compounds. These nano-biopesticides have fewer side effects as compared to directly applied chemical compounds. Nano-biopesticides have great potential to release active ingredients that are helpful in maintaining the different problems associated with agricultural systems, such as eutrophication. Although nano-biopesticides are widely used in different crops to control pests, their utilization in humans and animals remains unclear as they have entered into the food chain. More study is needed to characterize and formulate newly developed nano-biopesticides for controlling the different varieties of pests by ensuring no side effects on humans through the food chain [130].
As the world population increases rapidly, the feeding of humans will reach approximately 9 billion by 2050. It requires lots of nano-biopesticides to kill the pests and for the storage of food for long periods of time. It will be an emerging approach towards pest management that maintains environmental sustainability with fewer toxic effects on human health. The use of nano-biopesticides is also helpful in maintaining the nutrient balance in crops, minimize the risks to food security, and accumulating hazardous materials [131]. Nano-biopesticides have been extensively used in the agricultural fields for pest management or arthropod attack, but they possess chemical formulations that contain nano-particles that lead to toxicity concerns and health issues. These nano-biopesticides need to be standardized internationally to reduce their toxic effects on crops and the food chain. The use of nano-biopesticides in agriculture looks promising, but more research is needed in order to understand their toxic nature and monitor their application time to soils [132].
Approximatively, 25% of the world’s food yield is destroyed each year by the attack of pests. According to recent studies, using synthetic pesticides has been related to an increase in some illnesses, including Parkinson’s disease, neurotoxicity, type 2 diabetes, endocrine disruption, various malignancies, and even obesity. Insecticides produced from microorganisms or natural compounds are known as biopesticides. Due to their eco-friendliness, great efficacy, and few side effects, nano-biopesticides have gained in popularity over conventional pesticides over recent years. Biologically active pesticide compounds (APCs) may be produced in two ways: either by extracting APCs from plants and combining them with nano-particles or by inserting them into a polymer. As a result of their nano-size, high surface area/volume ratio, durability, enhanced effectiveness, greater solubility, mobility, and low toxicity, nano-biopesticides are superior to chemical pesticides. Biopesticides inhibit pathogen’s growth by altering their cellular structures and morphology and exhibit neurotoxicity on insects. As a result, nano-biopesticides are environmentally benign and have biodegradation characteristics; they assist in cleaning the environment by reducing the danger of harmful metal buildup in plants. However, the use of nano-sensors and nano-based smart delivery systems could help in the efficient use of agricultural, natural resources such as water, nutrients, and chemicals through precision farming. Moreover, it is recommended to use a nano-barcode, which is a novel method to monitor the quality of agricultural products.
Hereby, we extend our gratitude to A.Q Research Group, Pakistan for reviewing the article and providing helpful comments.
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All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
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\n\n\n\nIntechOpen is committed to disseminating high-quality scientific research in a manner that exemplifies the best practice in scholarly publishing. IntechOpen is an official member of the Committee on Publication Ethics (COPE), which advocates the maintenance of the highest ethical standards for all parties involved in the act of publishing, including Authors, Academic Editors of the book, Peer Reviewers, the publisher and Societies, where applicable.
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\n\nAll scientific works are subject to Peer Review prior to publishing. IntechOpen is a member of the Committee on Publication Ethics (COPE) and all participating referees and Academic Editors are expected to review submitted scientific works in line with the COPE Ethical Guidelines for Peer Reviewers where applicable.
\n\n\n\nThe Internet has changed the dynamics of scholarly communication and publishing which is why we find it necessary to clearly indicate our stance on what we consider to be a published scientific work. A significant number of working papers, early drafts, and similar works in progress are shared openly online between members of the scientific community. It has become common practice for researchers to announce their work on a personal website or a blog in order to gather comments and suggestions from other researchers. Such works and online postings are ‘published’ in the sense that they are made publicly available, but this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
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He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. 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Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. 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\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with the environment and promote the use of adequate management practices such as those outlined in the United Nations’ Sustainable Development Goals.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",keywords:"Anthropic effects, Overexploitation, Biodiversity loss, Degradation, Inadequate Management, SDGs adequate practices"},{id:"38",title:"Pollution",scope:"\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",keywords:"Human activity, Pollutants, Reduced risks, Population growth, Waste disposal, Remediation, Clean environment"},{id:"41",title:"Water Science",scope:"