Nagehan Ersoy Tunalı

Faculty memberIstanbul Medeniyet University

Nagehan Ersoy Tunalı has got her Ph.D., M.Sc. and B.Sc. degrees in Molecular Biology and Genetics at Boğaziçi University, Istanbul (TR). Her PhD work involved “Molecular Analysis of Polyglutamine Diseases and Investigation of the Interaction Between Huntingtin and Nuclear Receptor Corepressor”. She had the opportunity to get experienced in Huntington’s Disease (HD) research at University of Manchester (UK), CNR-Istituto di Medicina Sperimentale e Biotecnologie (IT) and University of Wales College of Medicine (UK). She served as the Editor-in Chief of Journal of Cell and Molecular Biology between years 2006 and 2016. Nagehan Ersoy Tunalı currently works as an Assistant Professor Dr at İstanbul Medeniyet University, Department of Molecular Biology and Genetics, Istanbul (TR). Her research interests cover molecular diagnosis of polyglutamine repeat diseases, genetic modifiers of HD, localization and interactions of huntingtin, and the molecular mechanisms of excitotocity in HD. Her interests are also extended to genetic susceptibility to kidney stone disease and urological cancers, biomarker analyses for bladder and breast cancers, pharmacogenetics and genetic analyses of childhood metabolic disorders.

2books edited

2chapters authored

Latest work with IntechOpen by Nagehan Ersoy Tunalı

Huntington's Disease is one of the well-studied neurodegenerative conditions, a quite devastating and currently incurable one. It is a brain disorder that causes certain types of neurons to become damaged, causing various parts of the brain to deteriorate and lose their function. This results in uncontrolled movements, loss of intellectual capabilities and behavioural disturbances. Since the identification of the causative mutation, there have been many significant developments in understanding the cellular and molecular perturbations. This book, "Huntington's Disease - Core Concepts and Current Advances", was prepared to serve as a source of up-to-date information on a wide range of issues involved in Huntington's Disease. It will help the clinicians, health care providers, researchers, graduate students and life science readers to increase their understanding of the clinical correlates, genetic aspects, neuropathological findings, cellular and molecular events and potential therapeutic interventions involved in HD. The book not only serves reviewed fundamental information on the disease but also presents original research in several disciplines, which collectively provide comprehensive description of the key issues in the area.

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