Open access peer-reviewed Edited Volume

Huntington's Disease

Molecular Pathogenesis and Current Models

Edited by Nagehan Ersoy Tunalı

Istanbul Medeniyet University

Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled movements of body parts, and deterioration of intellectual capabilities. The underlying complex mechanisms and molecular players of the cellular cascades still need to be deciphered in detail despite considerable advances. Once solved, the related molecular mechanisms will not only enlighten the HD story but will also shed light on other polyglutamine diseases and similar brain disorders. This book, Huntington's Disease-Molecular Pathogenesis and Current Models, is planned to cover recent scientific achievements in understanding the cellular mechanisms of HD. The chapters provide comprehensive description of the key issues in HD research. In this regard, this book will serve as a source for clinicians and researchers in the field and also for life science readers in increasing their understanding and awareness of the clinical correlates, genetic aspects, neuropathological findings, and potential therapeutic interventions related to HD.

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Huntington's DiseaseMolecular Pathogenesis and Current ModelsEdited by Nagehan Ersoy Tunalı

Published: March 22nd 2017

DOI: 10.5772/62999

ISBN: 978-953-51-3050-5

Print ISBN: 978-953-51-3049-9

eBook (PDF) ISBN: 978-953-51-4897-5

Copyright year: 2017

Books open for chapter submissions

7886 Total Chapter Downloads

7 Crossref Citations

3 Web of Science Citations

11 Dimensions Citations


Open access peer-reviewed

1. Genetic Modifiers of CAG.CTG Repeat Instability in Huntington's Disease Mouse Models

By Elodie Dandelot and Stéphanie Tomé


Open access peer-reviewed

2. NR1 Receptor Gene Variation is a Modifier of Age at Onset in Turkish Huntington’s Disease Patients

By Aysun Açar Hazer and Nagehan Ersoy Tunalı


Open access peer-reviewed

3. Pathogenesis of Huntington’s Disease: How to Fight Excitotoxicity and Transcriptional Dysregulation

By Marta Anglada-Huguet, Laura Vidal-Sancho, Nuria Cabezas-Llobet, Jordi Alberch and Xavier Xifró


Open access peer-reviewed

4. Porcine Model of Huntington's Disease

By Petra Rausova, Petra Vochozkova, Daniela Vidinska, Eva Hrnciarova, Bozena Bohuslavova, Monika Macakova, Ivona Valekova, Stefan Juhas, Taras Ardan, Petr Solc, Jan Motlik and Zdenka Ellederova


Open access peer-reviewed

5. Pluripotent Stem Cells to Model and Treat Huntington’s Disease

By Cristiane Valverde Wenceslau, Irina Kerkis, Celine Pompeia and Monica Santoro Haddad


Open access peer-reviewed

6. Transplantation in HD: Are We Transplanting the Right Cells?

By Sophie V. Precious and Claire M. Kelly


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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