Open access peer-reviewed Edited Volume

Huntington's Disease

Core Concepts and Current Advances

Edited by Nagehan Ersoy Tunalı

Istanbul Medeniyet University

Huntington's Disease is one of the well-studied neurodegenerative conditions, a quite devastating and currently incurable one. It is a brain disorder that causes certain types of neurons to become damaged, causing various parts of the brain to deteriorate and lose their function. This results in uncontrolled movements, loss of intellectual capabilities and behavioural disturbances. Since the identification of the causative mutation, there have been many significant developments in understanding the cellular and molecular perturbations. This book, "Huntington's Disease - Core Concepts and Current Advances", was prepared to serve as a source of up-to-date information on a wide range of issues involved in Huntington's Disease. It will help the clinicians, health care providers, researchers, graduate students and life science readers to increase their understanding of the clinical correlates, genetic aspects, neuropathological findings, cellular and molecular events and potential therapeutic interventions involved in HD. The book not only serves reviewed fundamental information on the disease but also presents original research in several disciplines, which collectively provide comprehensive description of the key issues in the area.

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Huntington's DiseaseCore Concepts and Current AdvancesEdited by Nagehan Ersoy Tunalı

Published: February 15th 2012

DOI: 10.5772/1470

ISBN: 978-953-307-953-0

eBook (PDF) ISBN: 978-953-51-4359-8

Copyright year: 2012

Books open for chapter submissions

51659 Total Chapter Downloads

10 Crossref Citations

26 Web of Science Citations

38 Dimensions Citations


Open access peer-reviewed

1. Retracted: Huntington’s Disease: From the Physiological Function of Huntingtin to the Disease

By Laurence Borgs, Juliette D. Godin, Brigitte Malgrange and Laurent Nguyen


Open access peer-reviewed

2. Modeling Huntington’s Disease: in vivo, in vitro, in silico

By Nagehan Ersoy Tunalı


Open access peer-reviewed

3. Molecular Mechanism of Huntington’s Disease — A Computational Perspective

By Giulia Rossetti and Alessandra Magistrato


Open access peer-reviewed

4. Biomarkers for Huntington’s Disease

By Jan Kobal, Luca Lovrečič and Borut Peterlin


Open access peer-reviewed

5. Quinolinate Accumulation in the Brains of the Quinolinate Phosphoribosyltransferase (QPRT) Knockout Mice

By Shin-Ichi Fukuoka, Rei Kawashima, Rei Asuma, Katsumi Shibata and Tsutomu Fukuwatari


Open access peer-reviewed

6. Alterations in Expression and Function of Phosphodiesterases in Huntington’s Disease

By Robert Laprairie, Greg Hosier, Matthew Hogel and Eileen M. Denovan-Wright


Open access peer-reviewed

7. Cognition in Huntington's Disease

By Tarja-Brita Robins Wahlin and Gerard J. Byrne


Open access peer-reviewed

8. Early Dysfunction of Neural Transmission and Cognitive Processing in Huntington’s Disease

By Michael I. Sandstrom, Sally Steffes-Lovdahl, Naveen Jayaprakash, Antigone Wolfram-Aduan and Gary L. Dunbar


Open access peer-reviewed

9. Endogenous Attention in Normal Elderly, Presymptomatic Huntington’s Disease and Huntington’s Disease Subjects

By Charles-Siegfried Peretti, Charles Peretti, Virginie-Anne Chouinard and Guy Chouinard


Open access peer-reviewed

10. Computational Investigations of Cognitive Impairment in Huntington's Disease

By Eddy J. Davelaar


Open access peer-reviewed

11. Targeting Transcriptional Dysregulation in Huntington’s Disease: Description of Therapeutic Approaches

By Manuela Basso


Open access peer-reviewed

12. ZNF395 (HDBP2 /PBF) is a Target Gene of Hif-1α

By Darko Jordanovski, Christine Herwartz and Gertrud Steger


Open access peer-reviewed

13. Role of Huntington’s Disease Protein in Post-Transcriptional Gene Regulatory Pathways

By Brady P. Culver and Naoko Tanese


Open access peer-reviewed

14. Energy Metabolism in Huntington’s Disease

By Fabíola M. Ribeiro, Tomas Dobransky, Eduardo A. D. Gervásio-Carvalho, Jader S. Cruz and Fernando A. Oliveira


Open access peer-reviewed

15. The Use of the Mitochondrial Toxin 3-NP to Uncover Cellular Dysfunction in Huntington’s Disease

By Elizabeth Hernández-Echeagaray, Gabriela De la Rosa-López and Ernesto Mendoza-Duarte


Open access peer-reviewed

16. Consequences of Mitochondrial Dysfunction in Huntington's Disease and Protection via Phosphorylation Pathways

By Teresa Cunha-Oliveira, Ildete Luísa Ferreira and A. Cristina Rego


Open access peer-reviewed

17. Cholesterol Metabolism in Huntington’s Disease

By Valerio Leoni, Claudio Caccia and Ingemar Björkhem


Open access peer-reviewed

18. Cellular Therapies for Huntington’s Disease

By C. M. Kelly and A. E. Rosser


Open access peer-reviewed

19. Ameliorating Huntington's Disease by Targeting Huntingtin mRNA

By Melvin M. Evers, Rinkse Vlamings, Yasin Temel and Willeke M. C. van Roon-Mom


Open access peer-reviewed

20. Don’t Take Away My P: Phosphatases as Therapeutic Targets in Huntington’s Disease

By Ana Saavedra, Jordi Alberch and Esther Pérez-Navarro


Open access peer-reviewed

21. BDNF in Huntington’s Disease: Role in Pathogenesis and Treatment

By Maryna Baydyuk and Baoji Xu


Open access peer-reviewed

22. Risk and Resilience: Living with a Neurological Condition with a Focus on Health Care Communications

By Kerstin Roger and Leslie Penner


Open access peer-reviewed

23. Communication Between Huntington’s Disease Patients, Their Support Persons and the Dental Hygienist Using Talking Mats

By Ulrika Ferm, Pernilla Eckerholm Wallfur, Elina Gelfgren and Lena Hartelius


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

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