Challa Sundaram

Senior Professor and Head, Department of Pathology, Nizam’s Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India. She did her MD Pathology at Andhra University, Visakhapatnam, Andhra Pradesh. She had her training in Neuropathology at Southern General Hospital, Glasgow, UK. She established the neuropathology services in her laboratory in the state of Andhra Pradesh and is actively involved in the diagnosis of Neurooncology, Neuroinfections and neuromuscular diseases. She published a large series of mitochondrial myopathies with particular emphasis on chronic progressive external opthalmoplegia on muscle biopsy and genetics. Her other contributions include proteomic studies in human gliomas and CNS fungal infections.

Challa Sundaram

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Latest work with IntechOpen by Challa Sundaram

Investigation of muscle diseases has changed dramatically with the understanding of genetic basis of a wide range of muscle diseases. Muscle biopsy has become a powerful tool not only to provide diagnosis but to make tissue available for genetic studies and to basic scientists for biomedical research. Accurate interpretation of muscle biopsy to detect cell dysfunction/ damage/death or absence / abnormality of a protein or genetic defect by the sophisticated technologies is important to guide treatment of various muscle diseases. In this book on muscle biopsy various chapters deal with the procedure and interpretation of muscle biopsy, its use in the culture of myotubes and membrane transport studies.Muscle biopsy is an important technique to investigate mitochondrial dysfunction and the mitochondrial DNA integrity in oxidation. Phosphorylation in various metabolic diseases like obesity, type 2 diabetes mellitus and peripheral vascular disease is explored in the other chapters with detailed descriptions on methodology. This book provides the advances in the basic techniques of muscle biopsy for a neuroscientist.

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