Summarization of our earlier studies on cell performance on NCD films and polymeric nanofibrous scaffolds loaded with diamond nanoparticles.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"4720",leadTitle:null,fullTitle:"Flow Cytometry - Select Topics",title:"Flow Cytometry",subtitle:"Select Topics",reviewType:"peer-reviewed",abstract:"Flow cytometry - Select Topics is a collection of chapters that illustrate the constantly evolving application of flow cytometry to diverse areas of research or clinical investigations. It includes chapters on the utilization of flow cytometry in the fields of human reproduction and fertility, platelet function, apoptosis, inflammation research, leukemia immunophenotyping, and transplantation.",isbn:"978-953-51-2551-8",printIsbn:"978-953-51-2550-1",pdfIsbn:"978-953-51-5445-7",doi:"10.5772/59733",price:119,priceEur:129,priceUsd:155,slug:"flow-cytometry-select-topics",numberOfPages:164,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"5a842a00d86bc7f956a5fd1fe6d62b8a",bookSignature:"Ingrid Schmid",publishedDate:"August 24th 2016",coverURL:"https://cdn.intechopen.com/books/images_new/4720.jpg",numberOfDownloads:14885,numberOfWosCitations:5,numberOfCrossrefCitations:7,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:11,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:23,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 21st 2015",dateEndSecondStepPublish:"October 12th 2015",dateEndThirdStepPublish:"January 8th 2016",dateEndFourthStepPublish:"February 7th 2016",dateEndFifthStepPublish:"March 8th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"109787",title:"M.Sc.",name:"Ingrid",middleName:null,surname:"Schmid",slug:"ingrid-schmid",fullName:"Ingrid Schmid",profilePictureURL:"https://mts.intechopen.com/storage/users/109787/images/system/109787.jpg",biography:"Ingrid Schmid, Mag. Pharm. is an Academic Research Specialist in the Department of Medicine at the University of California at Los Angeles and the technical director of the UCLA Flow Cytometry Resource which she established in 1989 in conjunction with Dr. Janis Giorgi. She received her Pharmaceutical Sciences degree from the University of Vienna, Austria. Ms. Schmid has a broad perspective on applications of various flow cytometry techniques and has developed numerous flow cytometry methods. She has published twenty-seven first-author papers, reviews, and book chapters, has co-authored an additional thirty-one publications, and has edited two books. Ms. Schmid is a member of the International Society for the Advancement of Cytometry Biosafety Committee and has served as its Chair between 1997 and 2007.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"University of California Los Angeles",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"403",title:"Microbial Genetics",slug:"karyology-microbial-genetics"}],chapters:[{id:"51694",title:"Sperm Flow Cytometry: Beyond Human Fertilization and Embryo Development",doi:"10.5772/64344",slug:"sperm-flow-cytometry-beyond-human-fertilization-and-embryo-development",totalDownloads:1679,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Male infertily is a contributing factor in up to 50% of all infertility cases, a solo cause in about 30% of them. Therefore, new and improved diagnostic methods that reduce operator variability regarding sperm defects that are not accesible by the conventional microscope scoring should be evaluated. Assisted reproductive technology (ART) has been involved in the description of alternative pathways in basic cellular functions. it is important to know that it is also related to the peri-implantatory processes that involve the sperm-oocyte interaction, cellular changes observed during fertilization, and the early and late embryo development. Several pathways have been involved at the early stages of human gametogenesis. The spermatozoon has demonstrated an intricate correlation during the fertilization process, as a transfected vector on genetic material, and as interacting with other inner components (RNAm, mitochondrial organelles, etc.). Spermatogenesis is affected by programmed death cell pathways from its packaging process through the elongated cytoplasmic structures during spermiogenesis. Flow cytometry (FC) has been an outstanding tool with the capability to select human gametes to achieve a better reproductive condition. It has been applied as a diagnostic and therapeutic tool allowing a measurable and objective selection and discrimination of spermatozoa from subfertile subjects. Using FC, we are able to know that early distribution of organelles such as mitochondria has an impact in embryo quality before genetic activation on the eight-cell stages occurs. This chapter will let the readers know the current knowledge on sperm fertilization and the relation between the embryo development and the offspring and all the tools now available for an early diagnosis and to identify therapeutic options with FC.",signatures:"Gerardo Barroso, Alexia Alvarez and Carlos Valdespin",downloadPdfUrl:"/chapter/pdf-download/51694",previewPdfUrl:"/chapter/pdf-preview/51694",authors:[{id:"111878",title:"Dr.",name:"Gerardo",surname:"Barroso",slug:"gerardo-barroso",fullName:"Gerardo Barroso"}],corrections:null},{id:"50807",title:"The Role of Cytometry for Male Fertility Assessment in Toxicology",doi:"10.5772/62965",slug:"the-role-of-cytometry-for-male-fertility-assessment-in-toxicology",totalDownloads:1862,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Infertility is nowadays a major concern, affecting approximately 8–12% of the couples and the male factor accounts for about 50% of the cases. Occupational and/or environmental exposure to heavy metals and other pollutants is the main cause of male infertility. Lead, cadmium and chromium are heavy metals widely used in industry and quite persistent in the environment, raising major concerns over the possible effects on the reproductive health of workers and the general population. Sperm DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. Flow cytometry can be to characterize multiple physical characteristics of the population of spermatozoa in the sperm, including sperm concentration, viability, mitochondrial mass and function, acrosome integrity, capacitation, membrane fluidity, DNA content and status, etc. This chapter elucidates the role of cytometry in the study of male fertility under toxicological insult by pollutants such as chromium, cadmium and lead. Some representative examples are presented using in vivo studies with rodents. In addition, complementary techniques to cytometry and future perspectives will be mentioned in an interdisciplinary point of view to gain knowledge on this subject.",signatures:"Maria de Lourdes Pereira, Helena Oliveira, Henrique M.A.C.\nFonseca, Fernando Garcia e Costa and Conceição Santos",downloadPdfUrl:"/chapter/pdf-download/50807",previewPdfUrl:"/chapter/pdf-preview/50807",authors:[{id:"79715",title:"Prof.",name:"Maria De Lourdes",surname:"Pereira",slug:"maria-de-lourdes-pereira",fullName:"Maria De Lourdes Pereira"},{id:"174419",title:"Prof.",name:"Fernando",surname:"Garcia E Costa",slug:"fernando-garcia-e-costa",fullName:"Fernando Garcia E Costa"},{id:"185982",title:"Prof.",name:"Helena",surname:"Oliveira",slug:"helena-oliveira",fullName:"Helena Oliveira"},{id:"185983",title:"Prof.",name:"Henrique M.A.C.",surname:"Fonseca",slug:"henrique-m.a.c.-fonseca",fullName:"Henrique M.A.C. Fonseca"},{id:"185984",title:"Prof.",name:"Conceição",surname:"Santos",slug:"conceicao-santos",fullName:"Conceição Santos"}],corrections:null},{id:"51423",title:"Only the Truth Would Enlighten Us — The Advantages and Disadvantages of Flow Cytometry as a Method of Choice in the Study of Mouse and Rat Platelets",doi:"10.5772/63473",slug:"only-the-truth-would-enlighten-us-the-advantages-and-disadvantages-of-flow-cytometry-as-a-method-of-",totalDownloads:1847,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Increasing number of transgenic and knockout strains of laboratory rodents has been developed to provide reliable models of human cardiovascular diseases. Due to apparent differences in platelet physiology, morphology, biochemistry, etc. between rodents and men, methods employed to study blood platelets in rodents should always consider these differences in a reasonably critical way. Flow cytometry is a convenient tool that enables to easily cope with the minute amounts of the available biological material and providing an extremely versatile information. This review focuses on the practical and methodological aspects of flow cytometry, pointing to the key elements of the commonly used protocols for determining of multiple parameters of blood platelet (patho)physiology in mice and rats. We summarized and critically reviewed the available procedures, as well as figured out how to overcome possible obstacles, shortcomings, drawbacks or artefacts that a researcher may encounter when monitoring various phenomena intimately associated with blood platelet biology. Flow cytometry assays have been also collated with some alternative techniques (intravital fluorescence microscopy, in vitro platelet adhesion under flow conditions). We hope that our paper may further facilitate other researchers to study mouse and rat platelets with the use of the most optimal and the least artefact-prone procedures.",signatures:"Hassan Kassassir, Karolina Siewiera, Tomasz Przygodzki, Magdalena Labieniec‐Watala and Cezary Watala",downloadPdfUrl:"/chapter/pdf-download/51423",previewPdfUrl:"/chapter/pdf-preview/51423",authors:[{id:"31394",title:"Dr.",name:"Magdalena",surname:"Labieniec-Watala",slug:"magdalena-labieniec-watala",fullName:"Magdalena Labieniec-Watala"},{id:"51050",title:"Ms.",name:"Karolina",surname:"Siewiera",slug:"karolina-siewiera",fullName:"Karolina Siewiera"},{id:"95368",title:"Dr.",name:"Tomasz",surname:"Przygodzki",slug:"tomasz-przygodzki",fullName:"Tomasz Przygodzki"},{id:"178693",title:"Ph.D.",name:"Hassan",surname:"Kassassir",slug:"hassan-kassassir",fullName:"Hassan Kassassir"},{id:"184177",title:"Prof.",name:"Cezary",surname:"Watala",slug:"cezary-watala",fullName:"Cezary Watala"}],corrections:null},{id:"48399",title:"The Multiplexing of Assays for the Measurement of Early Stages of Apoptosis by Polychromatic Flow Cytometry",doi:"10.5772/60549",slug:"the-multiplexing-of-assays-for-the-measurement-of-early-stages-of-apoptosis-by-polychromatic-flow-cy",totalDownloads:1743,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"The detection of apoptosis has been a stalwart application for flow cytometric analysis for decades and this review of flow cytometric methods to detect early stages of apoptosis includes the use of the pivotal assay to detect early and late apoptosis, the Annexin V assay which when multiplexed with biologically functional fluorescent dyes to measure mitochondrial function and Reactive Oxygen Species (ROS) generation allows further identification of functionally different subsets within apoptotic populations. Here we show how this polychromatic approach can be used to demonstrate which subset of cells show changes in mitochondrial function and when ROS is generated in a time dependent manner. This polychromatic approach to flow cytometry leads to the identification of over ten sub-populations of cells during classic apoptosis or programmed cell death (PCD).",signatures:"G. Warnes",downloadPdfUrl:"/chapter/pdf-download/48399",previewPdfUrl:"/chapter/pdf-preview/48399",authors:[{id:"108846",title:"Dr.",name:"Gary",surname:"Warnes",slug:"gary-warnes",fullName:"Gary Warnes"}],corrections:null},{id:"49202",title:"Effects of WF10 on Glycosaminoglycan Sulphation in Proinflammatory Monocytes and Macrophages",doi:"10.5772/60862",slug:"effects-of-wf10-on-glycosaminoglycan-sulphation-in-proinflammatory-monocytes-and-macrophages",totalDownloads:1346,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The chlorite-based drug solution WF10 has been successfully applied to dampen strong inflammatory disease states and to improve wound healing processes. However, the molecular mechanisms of this drug are not well understood. This study is directed to investigate how WF10 and its components affect the expression of surface markers and sulphated proteoglycans and glycosaminoglycans in proinflammatory-stimulated monocytes and macrophages.",signatures:"Maria Schönberg, Denise Schlorke and Jürgen Arnhold",downloadPdfUrl:"/chapter/pdf-download/49202",previewPdfUrl:"/chapter/pdf-preview/49202",authors:[{id:"115238",title:"Prof.",name:"Juergen",surname:"Arnhold",slug:"juergen-arnhold",fullName:"Juergen Arnhold"},{id:"174787",title:"Ph.D. Student",name:"Maria",surname:"Schönberg",slug:"maria-schonberg",fullName:"Maria Schönberg"},{id:"174897",title:"MSc.",name:"Denise",surname:"Schlorke",slug:"denise-schlorke",fullName:"Denise Schlorke"}],corrections:null},{id:"49878",title:"Immunophenotyping of Acute Leukemias – From Biology to Clinical Application",doi:"10.5772/62332",slug:"immunophenotyping-of-acute-leukemias-from-biology-to-clinical-application",totalDownloads:3285,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Immunophenotyping is an essential part of the modern diagnostic workup of acute leukemias and thus for an appropriate treatment of these complex and heterogeneous diseases. It provides a lot of useful information in this setting that transfers directly from laboratory to clinical management of patients. Lineage definition is the first goal leading to proper initial therapy. Some phenotypic patterns define specific subsets correlating with poor (mixed phenotype, dendritic cell neoplasm) or favorable (cortical T-lymphoblastic leukemia) outcome, thus guiding the application of treatment modalities. An advanced analysis of phenotypic data can address specific issues, such as the still debated role of multilineage dysplasia. The quality of response to chemotherapy is monitored by the detection of minimal residual disease and peripheral blast clearance during chemotherapy delivering. That allows a sharp discrimination of prognosis and again can drive the intensity of therapies proportionally to the disease chemosensitivity.",signatures:"Francesco Mannelli",downloadPdfUrl:"/chapter/pdf-download/49878",previewPdfUrl:"/chapter/pdf-preview/49878",authors:[{id:"178848",title:"M.D.",name:"Francesco",surname:"Mannelli",slug:"francesco-mannelli",fullName:"Francesco Mannelli"}],corrections:null},{id:"50878",title:"Detection of Anti-HLA Antibodies by Flow Cytometer",doi:"10.5772/62553",slug:"detection-of-anti-hla-antibodies-by-flow-cytometer",totalDownloads:3125,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Lives of patients with solid organ failure depend physically, emotionally, and economically on others. Improvement in organ transplantation is one of the most important medical breakthroughs of the twenty-first century. Being healthy upon organ transplantation is the second chance to live the life. This is frequently observed in heart-, lung-, and liver-transplanted patients. For instance, upon kidney transplantation, dialysis dependence terminates and life quality of the patients increases. The major difficulty in organ transplantation is the low number of organ donation. Thus, the number of patients in the waiting list for the cadaveric transplantation increases day by day. Under these limited circumstances, required conditions should be further provided for the long survival rates of recipients with allogeneic graft without any problem. Human leukocyte antigen (HLA) tissue typing and anti-HLA antibodies produced before and after the transplantation adversely affect the graft survival and thus the survival of an individual. Investigation of pretransplantation immune status of recipients is significant. Particularly, donor-specific anti-HLA antibodies determine early and long-term graft survival. Flow cytometer is one of the most important devices used in anti-HLA antibody detection and also for other clinical and scientific purposes. Compared to conventional methods, it supports transplantation clinics due to its high sensitivity and specificity. The use of flow cytometer dependent methods in transplantation field increases progressively.",signatures:"Tülay Kılıçaslan Ayna and Aslı Özkızılcık Koçyiğit",downloadPdfUrl:"/chapter/pdf-download/50878",previewPdfUrl:"/chapter/pdf-preview/50878",authors:[{id:"178265",title:"Dr.",name:"Tulay",surname:"Kilicaslan Ayna",slug:"tulay-kilicaslan-ayna",fullName:"Tulay Kilicaslan Ayna"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"1578",title:"Flow Cytometry",subtitle:"Recent Perspectives",isOpenForSubmission:!1,hash:"fccad401cbcf998ea4de62d524abf82d",slug:"flow-cytometry-recent-perspectives",bookSignature:"Ingrid Schmid",coverURL:"https://cdn.intechopen.com/books/images_new/1578.jpg",editedByType:"Edited by",editors:[{id:"109787",title:"M.Sc.",name:"Ingrid",surname:"Schmid",slug:"ingrid-schmid",fullName:"Ingrid Schmid"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2291",title:"Clinical Flow Cytometry",subtitle:"Emerging Applications",isOpenForSubmission:!1,hash:"a5414617aafe62d7c6ec8205028f6967",slug:"clinical-flow-cytometry-emerging-applications",bookSignature:"Ingrid Schmid",coverURL:"https://cdn.intechopen.com/books/images_new/2291.jpg",editedByType:"Edited by",editors:[{id:"109787",title:"M.Sc.",name:"Ingrid",surname:"Schmid",slug:"ingrid-schmid",fullName:"Ingrid Schmid"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3536",title:"Chromatin Remodelling",subtitle:null,isOpenForSubmission:!1,hash:"31abe97fe35989e4547bab854b38e03a",slug:"chromatin-remodelling",bookSignature:"Danuta Radzioch",coverURL:"https://cdn.intechopen.com/books/images_new/3536.jpg",editedByType:"Edited by",editors:[{id:"165250",title:"Dr.",name:"Danuta",surname:"Radzioch",slug:"danuta-radzioch",fullName:"Danuta Radzioch"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5085",title:"Telomere",subtitle:"A Complex End of a Chromosome",isOpenForSubmission:!1,hash:"2a8f40859d7bc312dea327fd9b058a20",slug:"telomere-a-complex-end-of-a-chromosome",bookSignature:"Marcelo L. Larramendy",coverURL:"https://cdn.intechopen.com/books/images_new/5085.jpg",editedByType:"Edited by",editors:[{id:"14764",title:"Dr.",name:"Marcelo L.",surname:"Larramendy",slug:"marcelo-l.-larramendy",fullName:"Marcelo L. Larramendy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"66304",slug:"corrigendum-to-pulsating-flow-effects-on-hydrodynamics-in-a-desalination-membrane-filled-with-spacer",title:"Corrigendum to: Pulsating Flow Effects on Hydrodynamics in a Desalination Membrane Filled with Spacers",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/66304.pdf",downloadPdfUrl:"/chapter/pdf-download/66304",previewPdfUrl:"/chapter/pdf-preview/66304",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/66304",risUrl:"/chapter/ris/66304",chapter:{id:"55536",slug:"pulsating-flow-effects-on-hydrodynamics-in-a-desalination-membrane-filled-with-spacers",signatures:"Armando A. Soares, João Silva, Eliseu Monteiro and Abel Rouboa",dateSubmitted:"September 25th 2016",dateReviewed:"March 27th 2017",datePrePublished:null,datePublished:"August 30th 2017",book:{id:"5768",title:"Desalination",subtitle:null,fullTitle:"Desalination",slug:"desalination",publishedDate:"August 30th 2017",bookSignature:"Taner Yonar",coverURL:"https://cdn.intechopen.com/books/images_new/5768.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"32956",title:"Dr.",name:"Taner",middleName:null,surname:"Yonar",slug:"taner-yonar",fullName:"Taner Yonar"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"59885",title:"PhD.",name:"Abel",middleName:null,surname:"Rouboa",fullName:"Abel Rouboa",slug:"abel-rouboa",email:"rouboa@utad.pt",position:null,institution:null}]}},chapter:{id:"55536",slug:"pulsating-flow-effects-on-hydrodynamics-in-a-desalination-membrane-filled-with-spacers",signatures:"Armando A. Soares, João Silva, Eliseu Monteiro and Abel Rouboa",dateSubmitted:"September 25th 2016",dateReviewed:"March 27th 2017",datePrePublished:null,datePublished:"August 30th 2017",book:{id:"5768",title:"Desalination",subtitle:null,fullTitle:"Desalination",slug:"desalination",publishedDate:"August 30th 2017",bookSignature:"Taner Yonar",coverURL:"https://cdn.intechopen.com/books/images_new/5768.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"32956",title:"Dr.",name:"Taner",middleName:null,surname:"Yonar",slug:"taner-yonar",fullName:"Taner Yonar"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"59885",title:"PhD.",name:"Abel",middleName:null,surname:"Rouboa",fullName:"Abel Rouboa",slug:"abel-rouboa",email:"rouboa@utad.pt",position:null,institution:null}]},book:{id:"5768",title:"Desalination",subtitle:null,fullTitle:"Desalination",slug:"desalination",publishedDate:"August 30th 2017",bookSignature:"Taner Yonar",coverURL:"https://cdn.intechopen.com/books/images_new/5768.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"32956",title:"Dr.",name:"Taner",middleName:null,surname:"Yonar",slug:"taner-yonar",fullName:"Taner Yonar"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11552",leadTitle:null,title:"Gamification - Analysis, Design and Development",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tPeople have been using point-scoring, rules of play, competition, and other typical elements of game playing since the beginning of the civilized world. Today, those techniques are employed within a wider cross-disciplinary context in novel application areas. Edutainment, marketing, transmedia, and games are only some domains that make heavy use of gamification while their utilization can extend to almost every domain that requires to motivate, encourages engagement with a process, a service, or a product.
\r\n\r\n\tThis book aims to capture the state of the art by collecting original research, models, frameworks, methodologies, case studies, innovative examples, new application areas, and future designs/concepts. The examples are intended to thematically categorized and enable the readers to appreciate the versatility of Gamification and identify the difficulties and characteristics of the process. The Editor believes that soon, the use of mixed reality technologies will increase the need for gamification in our social environment as the applications of that type will enable new interaction capabilities that will be highly benefitted by gamified processes.
",isbn:"978-1-80356-261-2",printIsbn:"978-1-80356-260-5",pdfIsbn:"978-1-80356-262-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"3406cce05d8d4bae8e3b4eab8189c8fc",bookSignature:"Dr. Ioannis Deliyannis",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11552.jpg",keywords:"Requirement Analysis, Gamification Methodologies, Gamified Process Modelling, Gamification Applications, Systems, Case Studies, Gamified Existing Processes, Novel Application Domains, Original Application Domains, Prototypes, Innovative Designs, New Concepts",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 10th 2022",dateEndSecondStepPublish:"March 10th 2022",dateEndThirdStepPublish:"May 9th 2022",dateEndFourthStepPublish:"July 28th 2022",dateEndFifthStepPublish:"September 26th 2022",remainingDaysToSecondStep:"2 months",secondStepPassed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"A pioneering researcher on interaction design, gamification, and game technologies used within innovative culture, education, learning, and entertainment experiences.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"103622",title:"Dr.",name:"Ioannis",middleName:null,surname:"Deliyannis",slug:"ioannis-deliyannis",fullName:"Ioannis Deliyannis",profilePictureURL:"https://mts.intechopen.com/storage/users/103622/images/system/103622.jpeg",biography:"Dr. Ioannis Deliyannis is an Associate Professor at Ionian University in Corfu. He is a member of the Faculty of the Department of Audio and Visual Arts and a founding member of the inArts research laboratory. He has created various interactive multimedia systems ranging from experimental television stations featuring multiple modes of delivery to educational and multi-sensory games. He is the author of a series of journal and conference publications in the above field and a series of books targeting the experimental and creative aspects of the technologies involved. He is involved in the design of user-centred software products and services, focusing on the use of mobile sensory systems to create intelligent interactive systems, entertainment education systems, games, gamified systems, educational applications for people with disabilities, multimedia adapters, holograms, interactive navigation narrative applications, augmented and virtual reality systems.",institutionString:"Ionian University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Ionian University",institutionURL:null,country:{name:"Greece"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"9",title:"Computer and Information Science",slug:"computer-and-information-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"440204",firstName:"Ana",lastName:"Cink",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/440204/images/20006_n.jpg",email:"ana.c@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"1978",title:"Interactive Multimedia",subtitle:null,isOpenForSubmission:!1,hash:"81343be857dbea4b8446359028998656",slug:"interactive-multimedia",bookSignature:"Ioannis Deliyannis",coverURL:"https://cdn.intechopen.com/books/images_new/1978.jpg",editedByType:"Edited by",editors:[{id:"103622",title:"Dr.",name:"Ioannis",surname:"Deliyannis",slug:"ioannis-deliyannis",fullName:"Ioannis Deliyannis"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7601",title:"Game Design and Intelligent Interaction",subtitle:null,isOpenForSubmission:!1,hash:"aef7c5d14fb716604538b9f7e1a3f2ef",slug:"game-design-and-intelligent-interaction",bookSignature:"Ioannis Deliyannis",coverURL:"https://cdn.intechopen.com/books/images_new/7601.jpg",editedByType:"Edited by",editors:[{id:"103622",title:"Dr.",name:"Ioannis",surname:"Deliyannis",slug:"ioannis-deliyannis",fullName:"Ioannis Deliyannis"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7417",title:"The Future of Television",subtitle:"Convergence of Content and Technology",isOpenForSubmission:!1,hash:"e9ae7433daa77973fd72130df6622c68",slug:"the-future-of-television-convergence-of-content-and-technology",bookSignature:"Ioannis Deliyannis",coverURL:"https://cdn.intechopen.com/books/images_new/7417.jpg",editedByType:"Edited by",editors:[{id:"103622",title:"Dr.",name:"Ioannis",surname:"Deliyannis",slug:"ioannis-deliyannis",fullName:"Ioannis Deliyannis"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"51099",title:"The Application of Nanodiamond in Biotechnology and Tissue Engineering",doi:"10.5772/63549",slug:"the-application-of-nanodiamond-in-biotechnology-and-tissue-engineering",body:'\nThe approaching nano- and biotechnological era expects the implementation of “smart” and “functional” materials, which will be used not only as a mechanically passive substrates, but also as active devices (i.e., electronic or optical devices and sensors, micro-electro-mechanical systems, smart drug delivery systems, bioactive substrates for the cell adhesion and growth, etc.).
\nDiamond represents a class of perspective multifunctional materials with morphological, chemical, optical and electronic properties tailorable on demand for specific needs, especially for life science, tissue engineering or regenerative medicine.
\nThe bonds between the carbon atoms in the diamond lattice are covalent and predominantly of sp3 hybridization [1, 2]. The diamond lattice of covalently bonded carbon atoms endows the diamond with extraordinary combination of intrinsic properties, particularly high hardness and thermal conductivity [3, 4]. The fracture toughness of the diamond has been measured to be 2 MPa m1/2, which is a relatively high value compared to other gemstones or other optical materials [5]. Diamond toughness is also dependent on the crystallographic plane on which the fracture force is expressed. The lowest cleavage energies were measured for the <111> plane [6]. The combination of the highest Young’s modulus, a high fracture toughness, a low friction coefficient and a low thermal expansion predetermines it as a material for protective layers and coatings. From optical point of view, diamond offers a unique combination of transparency in most of the ultraviolet, visible and infrared regions (from 227 nm to far IR). The refractive index of diamond is 2.41–2.44 (656–486 nm). As a semiconductor, diamond has an excellent combination of properties (except of electron mobility) [7, 8]. Other remarkable properties of diamond include a high wear resistance [9–11], pressure resistance [12], strong adhesion to the underlying substrate, i.e., when deposited in the form of films [10, 13, 14], a low friction coefficient [15] and high chemical stability (e.g., low reactivity and resistance to wet etching [2]). These properties can be further improved by various techniques of material engineering, e.g., by modulating the synthesis and structure of diamond and by various combinations of diamond with other elements and compounds. For example, hardness, fracture toughness, Young\'s modulus and wear resistance of diamond can be markedly enhanced by the preparation of diamond in the form of aggregated diamond nanorods [9], its hardness and thermal stability can be increased by nanotwinning with cubic boron nitride [4] and the adhesion of diamond films can be improved by laser treatment of the underlying substrate [14].
\nThe optical properties of the diamond are also excellent. Pure diamond transmits visible light and appears as a clear colorless crystal. However, diamond is capable of high optical dispersion (i.e., the ability to disperse light of different colors). In addition, although the diamond lattice is very strong and rigid, it can contain defects or be contaminated with foreign atoms (N, B, H, Ni, Co, Cr, Si), e.g., during the growth of diamond lattice. These elements can also be introduced into this lattice by ion implantation. The lattice defects and the presence of foreign atoms are responsible for the various colors of diamond, e.g., yellow and orange (nitrogen), brown (nitrogen and lattice defects), blue (boron), green (trace amounts of nickel or radiation exposure), gray (the presence of boron or unsaturated forms of carbon), black (inclusions of graphite and iron) or also purple, pink and red (due to changes in the electron structure by plastic deformation during traveling of diamonds from the Earth’s mantle to its surface
For all these outstanding properties, diamond is an attractive material for technical and industrial application, e.g., for polishing, machining, cutting and drilling tools. These tools are also useful for biomedical applications, e.g., for polishing biomaterials with diamond paste or cutting them with a diamond saw [23, 24], for bone resection or craniotomy using a diamond threadwire saw [25, 26] or for dental drilling in stomatology [27]. Other important fields for diamond application are electronics, optics or the jewelry trade.
\nThis chapter will concentrate on newly explored applications of diamond in biotechnologies and life sciences, such as bioimaging, biosensing, tissue engineering, controlled drug and gene delivery and for detecting and capturing various biomolecules and coating body implants. For some of these uses, diamond is attractive mainly in its nanosized or nanostructured form, namely free nanoparticles (1D), planar films from nanodiamonds (2D), and composites of diamond nanoparticles (DNPs) and other molecules, particularly polymers in the form of 3D scaffolds, as shown in Figure 1.
\nSchematic view of three diamond material forms representing free nanoparticles (1D), planar nanodiamond films (2D) and composite 3D scaffolds.
Our earlier studies included in this chapter were focused mainly on nanocrystalline diamond (NCD) films as substrates for the adhesion, growth and osteogenic differentiation of human bone-derived cells in the form of commercially available cell lines, namely human osteoblast-like MG 63 cells [20, 28–33] or Saos-2 cells [34–41], primary osteoblasts [42] and bone marrow mesenchymal stem cells (MSCs) [34, 42, 43]. The cell behavior on NCD films was further modulated by the size of the surface irregularities, measured by the root mean square (RMS) roughness parameter [34, 35], by the shape of these irregularities (nanocones and nanorods [36, 37], by termination of the NCD films with oxygen or hydrogen [38–42] and by doping of these films with boron [20, 32, 33]. NCD films micropatterned with H-terminated and O-terminated domains were also used for construction of biosensors [44]. Some of our studies were also dedicated to the construction of polymeric nanofibrous scaffolds reinforced with DNPs as potential scaffolds for bone tissue engineering. All the mentioned studies are summarized in Table 1.
\nReferences | \nTopic | \nCell model | \n
---|---|---|
Bacakova | \nCell adhesion and proliferation on nanostructured and hierarchically organized submicron- and nanostructured NCD films | \nMG 63 | \n
Grausova | \nCell adhesion and proliferation on nanostructured and hierarchically organized submicron- and nanostructured NCD films | \nMG 63, endothelial CPAE cells | \n
Grausova | \nAdhesion, proliferation, viability, mitochondrial activity and osteogenic differentiation of cells on nanostructured and hierarchically organized submicron- and nanostructured NCD films | \nMG 63 | \n
Grausova | \nAdhesion, osteogenic cell differentiation and immune activation of cells on nanostructured and hierarchically organized submicron- and nanostructured NCD films | \nMG 63 | \n
Broz | \nRegulation of the cell adhesion by the surface roughness of NCD films | \nSaos-2 MSC | \n
Kalbacova | \nRegulation of the osteogenic cell differentiation by the surface roughness of NCD films | \nSaos-2 | \n
Babchenko | \nRegulation of the cell adhesion by the shape of surface irregularities of the NCD films | \nSaos-2 | \n
Kalbacova | \nRegulation of the cell adhesion, activity of focal adhesion kinase and osteogenic cell differentiation by the shape of surface irregularities of the NCD films | \nSaos-2 | \n
Rezek | \nAdhesion and growth of cells on NCD films patterned with O-terminated and H-terminated microdomains | \nSaos-2 | \n
Ukraintsev | \nAdsorption of fetal bovine serum proteins and cell adhesion on NCD films patterned with O-terminated and H-terminated microdomains | \nSaos-2 | \n
Rezek | \nAdsorption of fibronectin and cell adhesion on NCD films patterned with O-terminated and H-terminated microdomains | \nSaos-2 | \n
Liskova | \nAdhesion, growth and osteogenic differentiation of cells on O- and H-terminated NCD films | \nSaos-2 | \n
Liskova | \nAdhesion, growth and osteogenic differentiation of cells on O- and H-terminated NCD films | \nMSC, primary osteoblasts | \n
Izak | \nApplication of NCD films patterned with O- and H-terminated microdomains for construction of impedance-based sensor for real-time monitoring of cell growth | \nMG 63 | \n
Kopecek | \nAdhesion, growth and osteogenic differentiation of cells on boron-doped NCD films | \nMG 63 | \n
Kromka | \nAdhesion, growth and osteogenic differentiation of cells on boron-doped NCD films | \nMG 63 | \n
Grausova | \nAdhesion, growth and osteogenic differentiation of cells on boron-doped NCD films | \nMG 63 | \n
Parizek | \nCell adhesion and growth on nanofibrous PLGA-nanodiamond scaffolds | \nMG 63 | \n
Brady | \nCell adhesion and growth on nanofibrous PLGA-nanodiamond scaffolds | \nMSC | \n
Bacakova | \nCell adhesion and growth on nanofibrous PLLA-nanodiamond scaffolds | \nMG 63, Saos-2 | \n
Summarization of our earlier studies on cell performance on NCD films and polymeric nanofibrous scaffolds loaded with diamond nanoparticles.
Individual DNPs can be advantageously used for drug and gene delivery, bioimaging technologies and biosensor construction. For these purposes, it is necessary to attach various atoms or molecules on the DNP surface, to achieve good dispersiveness of the DNPs in aqueous solutions, such as drug vehicles, buffers, physiological solution, cell culture media or body fluids and also to add chemical functionality to the DNPs in order to enable the uptake of DNPs by cells. DNPs have a high surface/volume ratio, i.e., they have a relatively large surface, on which not only atoms and small molecules, but also macromolecules (e.g., various drugs, nucleic acids and proteins) can be attached by physi- or chemisorption (for a review, see [47]). However, this attachment can be limited, for example, due to DNP hydrophobicity and tendency to aggregate in aqueous solutions. Thus, it is necessary to engineer the surface of DNPs for their specific applications [2]. The attachment of synthetic and biological molecules to the nanodiamond surface and the dispersion of DNPs in the aqueous media can be improved by various types of functionalization of the nanodiamond surface, e.g., by oxygen-containing chemical functional groups, such as –OH, −COOH [48–50], amine groups [48, 51] and by various biomolecules, such as lysine [52], biotin [53], thionine, trimethylamine [49], polyglycerol [54, 55] and RGD-containing oligopeptides, i.e., ligands for adhesion receptors on the cell surface [54, 56]. This functionalization can also improve the penetration of DNPs into cells (i.e., by crossing cytoplasmic and nuclear membranes) or by their internalization through clathrin-mediated endocytosis [57–59]. Functionalization of the DNPs with thiol groups (−SH) enables their conjugation with gold and silver nanoparticles [60, 61]. Such complexes are promising for photothermal therapy against tumors [60].
\nNanodiamond-based drug delivery has been developed particularly for advanced tumor therapies, e.g., the treatment of multidrug-chemoresistant leukemia. In experiments
Other therapeutic molecules which can be delivered into cells through DNPs include cell growth and differentiation factors, antibodies, vaccines and anti-inflammatory drugs. For example, basic fibroblast growth factor (bFGF) and bone morphogenetic protein-2 (BMP-2) were loaded onto DNPs by physisorption, forming a stable colloidal solution. This solution enabled the release of both factors in slightly acidic conditions, induced the proliferation and osteogenic differentiation of osteoblast progenitor cells and was injectable. Thus, this solution was an effective alternative to the currently used delivery of bFGF and BMP-2 to the surgical site by the implantation of bulky collagen sponges [69]. Carboxylated DNPs conjugated with growth hormone were tested for a specific targeting growth hormone receptor in cancer cells and potential anticancer therapy [70].
\nDNPs can also serve as a stable delivery platform for therapeutic antibodies, as revealed by studies on the transforming growth factor β (TGF-β) antibody. The complexes of this antibody with DNPs were stable in water, but under physiological conditions simulated in serum-supplemented cell culture, the release of the active antibody was detected [71]. An interesting newly developed application of DNPs is delivering vaccines through the skin for painless and efficient immunization. These nanoparticles could improve limited drug delivery through the stratum corneum, which has a very dense structure and only allows the penetration of small molecules with a molecular weight of below 500 Da (for a review, see [72]). Fluorescent nanodiamonds functionalized by hyperbranched polyglycerol also proved to be promising carriers for delivering aluminum oxyhydroxide, i.e., a compound widely used as an immunologic adjuvant of vaccines [73].
\nFor localized drug delivery, DNPs can be incorporated into various materials, e.g., films for potential implant coating [74]. For example, aqueous dispersible detonation nanodiamonds were assembled into a closely packed multilayer nanofilm with positively charged poly-L-lysine
DNPs can also be effectively used for the proteolysis and digestion of glycopeptides. Trypsin and peptide-N-glycosidase F, immobilized on detonation nanodiamond, were more efficient than the free enzymes or commercially available beads immobilized with trypsin [75].
\nAs for gene delivery, DNPs can act as excellent nonviral vectors for binding and transferring plasmid DNA and small interfering RNA (siRNA), particularly after functionalization, e.g., with –OH groups [49] or lysine [52]. DNPs, rendered cationic by coating with polyethyleneimine or by termination with hydrogen in plasma, efficiently delivered siRNA into Ewing sarcoma cells and blocked the expression of EWS/FLI-1 oncogene in these cells. In addition, the association of EWS/FLI-1 silencing by the siRNA/nanodiamond complex with a vincristine treatment potentiated the cytotoxic effect of this chemotherapeutic drug [59]. Similarly, DNPs conjugated with RGD oligopeptides and siRNA for vascular endothelial growth factor (VEGF) can be used in antiangiogenic gene therapy to inhibit tumor growth
Due to stable and controllable photoluminescence, DNPs are also promising for advanced bioimaging techniques. Like the various colors of diamonds, mentioned above, this photoluminescence is based on crystallographic defects and particularly on optical centers created by the incorporation of foreign atoms (N, Si or Cr) into the diamond lattice. DNPs with a nitrogen-vacancy (NV) color center were detectable in living cells
The optical activity of the luminescent color centers in DNPs depends on their proximity to the nanoparticle surface and its surface termination [2]. The photoluminescence can also be modulated by changes in the environment surrounding the DNPs. For example, coating the DNPs with a polymer film resulted in a reduction of the lifetime of NV centers and an average enhancement in their emission rate [78]. For photoacoustic imaging in biological tissues, nanodiamonds with very high absorption in the near-infrared range can be created by irradiation with the He+ ion beam [79]. The fluorescence of DNPs can also be induced by surface passivation of the DNPs with bis(3-aminopropyl) terminated poly(ethylene glycol) [60]. A nanodiamond-polyglycerol-gadolinium(II) conjugate was designed and prepared as a novel nanodiamond-based magnetic resonance contrast agent dispersible in physiological media [55]. For combined bioimaging and drug delivery, photoluminescent DNPs were coated with a porous SiO2 shell [80].
\nDNPs with an NV color center are also emerging tools for nanoscale sensing, e.g., sensing molecular fluctuations and temperatures in live cellular environments, detecting and measuring magnetic and electric fields, and measuring ion concentrations and cell membrane potentials [17, 18]. DNPs immobilized onto a gold electrode by direct adsorption were used as a biosensor for determining the concentration of glucose and lactate [81]. Arrays of DNPs in the form of nanoneedles were applied for intracellular sensing, e.g., of intracellular signaling through NF-kB, translocated from the cell cytoplasm to the nucleus region [76]. Other sensoric applications of nanodiamonds require the creation of continuous diamond films, and they are discussed in Section 3 (Nanostructured diamond films).
\nFor all the applications mentioned above, it is necessary to use nontoxic nanoparticles. DNPs are generally considered as materials with little, if any cytotoxicity. These nanoparticles dispersed in the cell culture media did not affect the adhesion, growth, viability and differentiation of various cell types (for a review, see [82, 83]). For example, the addition of DNPs in the culture medium did not affect the adhesion, growth and adipogenic or osteogenic differentiation of human adipose tissue-derived stem cells [84]. Also the labeling of lung stem cells with fluorescent DNPs
In spite of these encouraging findings, the number of reports on nanodiamond cytotoxicity is increasing. The first report demonstrated the damage and destruction of human erythrocytes and leucocytes by DNPs [85, 86]. For low and moderate concentrations, DNPs did not negatively influence the viability of isolated inflammatory neutrophils and even enhanced their response to bacterial agents. However, the viability and antibacterial reaction of these cells was suppressed at high concentrations of DNPs (≥1 g/l; [87]). Similar reactions of neutrophils were also observed
The adverse effects of DNPs have usually been attributed to the oxidative stress generated by these particles [92, 95, 97, 98]. DNPs created by detonation synthesis affected the cellular content of glutathione and the activities of the main antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase) in human umbilical vein endothelial cells
The cytotoxicity of DNPs depends on their origin, size, surface functionalization, tendency to form aggregates and the presence of impurities. In studies reporting the adverse effects of DNPs, these nanoparticles were often prepared by detonation [85, 86, 90, 93, 96, 97], while in studies indicating the nontoxic effects of DNPs on cell behavior, the DNPs were prepared by non-detonation methods, e.g., milling diamond microcrystals [73, 99]. The detonation DNPs, also called ultrananocrystalline detonation diamond (UDD), are generally of smaller size (in nanometers) than non-detonation DNPs (tens of nanometers), and this small size has been considered as the main determinant of nanoparticle cytotoxicity [91]. The detonation diamonds often contain impurities, such as other carbon allotropes [53], iridium [100], carbon soot and oxides and carbides, including those of iron, chromium, silicon, calcium, copper, potassium, titanium and sulfur (for a review, see [1]). In a study by Keremidarska et al. [96], the increased cytotoxicity of DNPs was associated with their smaller size and presence of impurities, particularly other carbon allotropes. Thus, for biomedical studies, detonation nanodiamonds need to be extensively purified. For the removal of nondiamond carbon, the following chemicals can be used: ozone-enriched air, liquid oxidants such as HNO3, HClO4 or different acid mixture under pressure; metal impurities can be removed by treatment with HCl, H2SO4 and its mixtures with HNO3 or potassium dichromate (for a review, see [1, 96]).
\nThe functionalization influence of detonation DNPs on their biocompatibility is controversial. Detonation nanodiamonds covered by cobalt ions showed a protective effect against contact dermatitis in mini-pigs, induced by local exposure of the animal skin to these ions [101]. Detonation nanodiamonds with hyperbranched polyglycerol coating showed good cytocompatibility with A549 cancer cells and U937 macrophages [54]. Detonation nanodiamonds functionalized with thiol groups and conjugated with gold nanoparticles did not show significant cytotoxicity to a human lung carcinoma cell line [61]. On the other hand, detonation DNPs terminated with oxygen showed higher cytotoxicity to mouse embryonic stem cells than pristine unmodified DNPs, although this cytotoxicity was lower than in multiwalled carbon nanotubes [93].
\nIn our studies, we compared the potential cytotoxicity of DNPs from three different origins. DNPs fabricated in the Nano Carbon Research Institute (Japan) under the product name NanoAmando were prepared by a detonation method and were hydrogen-terminated. A part of these DNPs was oxygen-terminated by annealing at 450°C in air. The size of both unmodified and O-terminated detonation DNPs was only about 5 nm. The DNPs, which were acquired from Microdiamant AG (Switzerland) named MSY (Monocrystalline SYnthetic), were prepared using a high pressure high temperature (HPHT) method and were oxygen-terminated due to postproduction acid treatment by the producer. These DNPs were not further modified and were provided in several sizes ranging from 18 to 210 nm. The DNPs acquired from Adámas Nanotechnologies, Inc. (Raleigh, U.S.A.) were prepared using the HPHT method and were already provided in a water colloid with a concentration of 1000 mg/l. The size of these nanoparticles was 40 nm. The Adámas DNPs had intrinsic red fluorescence based on NV defects in their diamond lattice, which was further activated by annealing in a vacuum at 800°C.
\nThe number and mitochondrial activity (measured by MTS test) of human osteoblast-like Saos-2 cells in 3-day-old cultures exposed to NanoAmando (NA), MSY and Adámas (A) diamond nanoparticles suspended in cell culture medium (concentrations from 10 to 1000 μg/ml) for 48 hours of cultivation. Control cells were cultivated in pure medium without diamond nanoparticles. Mean ± S.D. (standard deviation).
Micrographs of cells cultivated for 48 hours with Adámas DNPs Olympus IX 71, obj. 40×. Phase contrast image (A), red fluorescence of Adámas DNPs in grayscale (B), and merged images A and B (C).
The DNPs were dispersed by ultrasonication in water to obtain a colloid with a DNP concentration of 10,000 μg/ml, and added to 24-hour-old cultures of human osteoblast-like Saos-2 cells in concentrations of 10, 100 or 1000 μg/ml of the culture medium. After 48 hours, the cell number was evaluated by cell counting on recorded microphotographs using Image J software and correlated with the activity of mitochondrial enzymes measured by a commercially available MTS test (Promega). The lowest cell numbers and mitochondrial activity were obtained in cultures with unmodified NanoAmando DNPs, and these values decreased with increasing nanoparticle concentration (Figure 2). The cell numbers slightly improved in cultures with annealed NanoAmando DNPs, but they did not reach the average values obtained in MSY and Adámas DNPs. Only the mitochondrial activity of cells cultured with annealed NanoAmando DNPs reached similar values to the cells exposed to MSY and Adámas DNPs. The annealing of DNPs at a high temperature probably had a similar effect to the chemical purification of DNPs in oxidizing agents. The fluorescence of Adámas DNPs was detected inside the fixed cells after 2 days of cultivation using the standard epifluorescence microscope Olympus IX 71 (Figure 3).
\nOur earlier studies and studies by other authors showed that NCD films provided excellent substrates for the adhesion, growth and phenotypic maturation of various cell types, such as neuronal and glial cells [102–104], epithelial cells [105], vascular endothelial cells [29], fibroblasts [106] and particularly bone-derived cells (for a review, see [82, 83, 107]). The latter cells included commercially available lines of osteoblast-like cells (MG 63 [20, 28–33], Saos-2 [30, 31, 35, 41, 108]), primary human osteoblasts [42] and human bone marrow MSCs [42, 108, 109].
\nThe positive effects of NCD films on cell performance can be explained by their nanostructure, i.e., the presence of irregularities at the nanoscale level on their surface (e.g., an average roughness Ra parameter equal or less than 100 nm). On these surfaces, the cell adhesion-mediating proteins present in biological fluids (e.g., fibronectin and vitronectin in the serum supplement of the culture media) are adsorbed in a favorable geometrical conformation enabling the exposure of specific adhesion sites in these proteins (e.g., RGD motifs) to the cell adhesion receptors, i.e., integrins. In addition, it is believed that the nanostructured surfaces preferentially adsorb vitronectin (due to its relatively small and linear molecule), which is favorably recognized by osteoblasts through its KRSR amino acid sequence [110, 111] (for a review, see [107, 112]). Thus, the NCD films are promising particularly for the surface coating of bone and dental implants. In accordance with this concept, submicron crystalline diamond films (grain sizes 200–1000 nm) and particularly microcrystalline diamond films (grain size up to 2 μm) supported the adhesion and spreading of osteoblasts to a lesser extent than NCD films [113, 114]. Also in our earlier study, the number of human osteoblast-like Saos-2 cells adhering to NCD films deposited on silicone substrates of various roughness (RMS of 20, 270 and 500 nm) decreased with the increasing substrate roughness [34]. In addition, the NCD films of RMS of 20 nm and 270 nm supported better the osteogenic differentiation of Saos-2 cells than the surfaces of a RMS of 500 nm, as manifested by a higher activity of alkaline phosphatase and a higher cellular content of calcium and phosphates [35]. Similarly, on NCD films with hierarchically-organized submicron and nanoscale surface roughness (RMS of 301.0 nm and 7.6 nm, respectively), the MG 63 cells adhered in lower initial numbers than on nanorough only surfaces (RMS 8.2 nm), although the subsequent cell proliferation was higher on the hierarchically-organized surfaces [28].
\nNot only the size but also the shape of the surface irregularities on the diamond films is an important factor regulating the cell behavior. For example, in our earlier studies, two different types of nanoscale features, namely nanocones and nanorods, were prepared by plasma etching of nanodiamond films using Au and Ni masks, respectively. As revealed by immunofluorescence staining of vinculin, Saos-2 cells cultivated on relatively short and broad nanocones (height 5–100 nm, diameter up to 80 nm) formed less numerous but large focal adhesions, while the cells cultivated on relatively high and thin nanorods (height 120–200 nm, diameter 20–40 nm) formed more numerous, but very thin and fine focal adhesions [37]. The large focal adhesions on nanocones were associated with stronger cell adhesion, increased activation of focal adhesion kinase (FAK), and were better predestined for osteogenic cell differentiation [36].
\nIn contrast to free DNPs, to the best of our knowledge, no study reported the cytotoxicity of NCD films. This may be due to the fact that NCD films are compact, chemically and mechanically stable and their surface is much better defined/controlled than the surface of DNPs. Moreover, planar NCD films do not interfere and/or penetrate into the cells. The surface termination of NanoAmando DNPs controlled by high-temperature treatment was shown as a crucial parameter for their cytotoxicity (see Section 3.4). NCD films were not cytotoxic even if NanoAmando DNPs were used for the substrate seeding prior to NCD deposition.
\nNCD films have usually been synthesized from methane or fullerene C60 precursors using the microwave plasma-enhanced chemical vapor deposition (MW PECVD) method. NCD films have been deposited on various substrates such as the silicon, glass or metals currently used in orthopedics and stomatology, e.g., Ti [115] and Ti-6Al-4V [116] (for a review, see [82, 83]). On these substrates, the NCD films behave as well-adhering, highly cohesive and mechanically and chemically resistant coatings. Not only were their potential adverse effects suppressed, but no particles were released from the compact films, which in addition behaved as a passivation barrier for particles and ions from the underlying materials. For example, silicon wafers, which are currently being used as experimental substrates for NCD deposition and behaved as cytotoxic for human osteoblast-like MG 63 cells and vascular endothelial CPAE cells, were rendered highly compatible with these cells by their continuous and hermetic encapsulation with NCD films [29].
\nCell performance on NCD films can be further modulated by their functionalization with various atoms, chemical functional groups or biomolecules. For example, the adhesion, growth and osteogenic differentiation of bone-derived cells were better on O-terminated than on H-terminated NCD films. Human osteoblast-like Saos-2 cells, primary human osteoblasts and bone marrow MSCs in cultures on O-terminated NCD films showed better-developed focal adhesion plaques (Figure 4), reached higher cell population densities and produced more collagen I and alkaline phosphatase (i.e., an early and middle marker of osteogenic cell differentiation, respectively). The cells on O-terminated surfaces also showed a higher activity of alkaline phosphatase, i.e., an enzyme participating in bone matrix mineralization, and accordingly with it, these cells produced more calcium in their extracellular matrix (ECM) [41, 42]. Furthermore, human dental stem cells cultured on O-terminated diamond films deposited more ECM than on H-terminated films, and this matrix contained higher levels of calcium, oxygen and phosphorus [117]. Similar behavior has also been observed in human renal epithelial HK-2 cells cultured on borosilicate glass with NCD films. On the films terminated with O, these cells adhered and grew better than on H-terminated NCD films and uncoated borosilicate glass [105]. When NCD films were constructed as micropatterned films, i.e., with domains terminated with O or H, e.g., in the form of stripes of 30–200 μm in width, the cells adhered and grew preferentially on the O-terminated domains [38, 117].
\nThe immunofluorescence of paxillin (green), a protein of focal adhesion plaques, in primary human osteoblasts on day 7 after seeding on H-terminated (Diam. H) and O-terminated (Diam. O) NCD films. Actin cytoskeleton is stained with Phalloidin-Texas Red, cell nuclei with Hoechst #33342 (blue). Bar = 25 μm.
The positive influence of O-terminated diamond films on cell behavior has been explained by the higher polar component of the free surface energy and higher wettability of these films [118] (for a review, see [41]). It is known that wettable surfaces (similar to the nanostructured surfaces mentioned above) promote the adsorption of cell adhesion-mediating molecules in a bioactive and flexible geometrical conformation, and their effective recognition and binding by the cell adhesion receptors (for a review, see [112]). Our earlier study showed that the fetal bovine serum (FBS), i.e., an important supplement of standard cell culture media and an important source of cell adhesion-mediating proteins (e.g., vitronectin, fibronectin), formed more compact and better-adherent films on O-terminated NCD surfaces than on H-terminated NCD, where the FBS layer tended to peel from the material surface [40]. The following experiments with preadsorption of NCD films with O-terminated and H-terminated microdomains with FBS proteins revealed that the preferential growth of Saos-2 cells on O-terminated domains is mediated by fibronectin [39].
\nPositive effects on surface polarity, wettability and cell adhesion were also observed in NCD films terminated with amine groups, which upregulated the adhesion of human femur osteoblasts [115, 118], or supported the adhesion of dorsal root ganglion neurons and Schwann cells isolated from Wistar rats and NG108-15 neuroblastoma-glioma hybrid cells [102].
\nHowever, in the case of the neural stem cells derived from mouse embryos, both the O-terminated and H-terminated NCD surfaces effectively supported well the cell proliferation, and this proliferation was even slightly better on H-terminated surfaces. Moreover, H-terminated NCD films were able to spontaneously induce (i.e., without the presence of differentiation factors in the culture medium) differentiation of the stem cells into neurons, while on O-terminated NCD films, the cells preferentially differentiated into oligodendrocytes [103]. The neuronal cell differentiation on H-terminated NCD films was explained by the high accumulation of fibronectin on these films, which then activated a signaling pathway involving β1-integrin adhesion receptors, FAK and mitogen-activated protein kinase/extracellular signaling-regulated kinase1/2 (MAPK/Erk1/2) [104]. Thus, the H-terminated surfaces seemed to have a greater potential to promote the regeneration of neurons in a damaged central nervous system (which is considered as impossible in human patients) than O-terminated surfaces.
\nThus, the results of cell performance on H-terminated and O-terminated NCD films, obtained by various authors, are controversial. This disproportion can be attributed to different NCD qualities (the presence of non-diamond carbon phases, different grain size, etc.), the different reactivity of various cell types (neural, epithelial, osteogenic) or different cultivation conditions. For example, the studies by Chen et al. [103, 104] were performed using a medium with a low concentration of serum (only 2% of FBS), while the experiments with osteogenic cells were generally carried out in standard cell culture media supplemented with 10–15% of FBS. When osteogenic cells were cultured in a serum-free medium, no differences in cell adhesion on O- and H-terminated NCD domains were observed [38]. Another explanation could be the relatively high hydrophilicity of O-terminated surfaces (water drop contact angle ~20°
Another important modification of NCD films influencing cell behavior is the boron doping of these films. Lower concentrations of boron (approximately 100–1000 ppm of B) supported the proliferation and early osteogenic differentiation of human osteoblast-like MG 63 cells, which was manifested by an increased cell number and increased concentration of collagen I and alkaline phosphatase in the cells. Higher concentrations of boron (6700 ppm of B) enhanced cell adhesion and osteogenic cell differentiation, manifested by increased concentrations of vinculin, a focal adhesion protein, and osteocalcin, a calcium-binding ECM glycoprotein. These effects were probably due to the increased electrical conductivity of NCD films after boron doping [32]. It is known that electroactive materials are able to enhance the adhesion, growth and phenotypic maturation on various cell types, even without active stimulation with an electrical current (for a review, see [83, 112]).
\nAlso, composite apatite-nanodiamond coatings were shown to improve the performance of bone cells. When electrodeposited on stainless steel, these coatings markedly enhanced the attachment, spreading and formation of focal adhesion plaques in osteoblast-like MG 63 cells, compared to the pure stainless steel and apatite coatings without nanodiamond, which was mediated by an increased adsorption of fibronectin on the composite coatings and its deposition by the cells [119].
\nNanocrystalline and polycrystalline diamond films are also important for constructing biosensors. For example, NCD films patterned with O- and H-terminated microdomains were used for the construction of an impedance-based sensor for real-time monitoring of cell growth, and successfully applied in cultures of human osteoblast-like MG 63 cells [44]. An aptasensor for platelet-derived growth factor (PDGF) was designed on a NCD surface functionalized with carboxylic and amine groups, which served as units for immobilizing PDGF-binding aptamers [120]. Arrays based on polycrystalline diamond surfaces grafted with odorant binding proteins (i.e., small soluble proteins present in olfactory systems) were fabricated for potential artificial olfaction applications [121]. Electrodes coated with boron-doped diamond (BDD) films are also excellent materials for the construction of biosensors, especially after further modifications with other nanoparticles and molecules [122]. For example, a BDD electrode modified with silver nanoparticles was developed as a cholesterol sensor [123]. A biosensor for the detection of L-serine was fabricated using a BDD electrode modified with polycrystalline nickel and nickel(II) oxide (Ni-NiO) half nanotubes [124]. A BDD electrode modified with platinum nanoparticles (serving as a highly conductive catalytic transducer, and coupled with a competitive magneto-enzyme immunoassay), was used for the detection and degradation of the pesticide atrazine [125]. An electrochemical sensor for glutamate, an important neurotransmitter in the mammalian central nervous system, was fabricated on doped chemical vapor deposition diamond electrodes and graphene nanoplatelet structures [126]. Diamond coatings also enhanced the sensitivity and operation range of optical fiber sensors [127].
\nAs for the drug delivery, oxidized ultrananocrystalline diamond thin films were functionalized with type I collagen and an anti-inflammatory drug dexamethasone, in order to fabricate a hybrid therapeutically active substrate for localized drug delivery [128].
\nAnother promising group of materials for biomedical applications, particularly for bone tissue engineering, is polymer-nanodiamond composites. Polymers in general are too soft and elastic for bone tissue engineering, and thus they require reinforcements with harder and stronger materials, e.g., ceramic, metallic or carbon nanoparticles, including DNPs. Polymers reinforced with DNPs have been used in the form of thin films, e.g., poly(L-lactide) (PLLA) films [129, 130], or as electrospun nanofibrous scaffolds made of poly(lactide-co-glycolide) (PLGA) [43, 45]. Both types of composites showed improved mechanical properties and effectively supported the adhesion and growth of osteoblast-like MG 63 cells and human bone marrow MSCs (Figure 5). In the case of PLLA films, fluorescent DNPs were used in order to localize these materials in tissues after implantation and to investigate their behavior
The morphology of pure PLGA nanofibrous scaffolds (A), PLGA scaffolds loaded with ~23 wt.% of diamond nanoparticles (B) and human bone marrow mesenchymal stem cells on day 9 after seeding on the PLGA (C) or PLGA-nanodiamond (D) scaffolds. A, B: scanning electron microscope, bar = 10 μm. C, D: cell membrane and cytoplasm stained with Texas Red C2-Maleimide; cell nuclei counterstained with Hoechst #33342. Leica SPE confocal microscope, bar = 20 μm.
However, nanofibrous PLLA-nanodiamond scaffolds exerted rather adverse effects on their colonization with bone cells. The number, mitochondrial activity and expression of some markers of osteogenic differentiation at the mRNA and protein level in the human osteoblast-like MG 63 and Saos-2 cells cultured on these scaffolds decreased with the increasing concentration of DNPs in these scaffolds (from about 0.4 to 12 wt.%; [46]). At the same time, the concentration of DNPs in nanofibrous PLGA-nanodiamond scaffolds was considerably higher, i.e., ~23 wt.% [43, 45]. The different cell behavior on the PLGA- and PLLA-based scaffolds was probably due to the different origin and properties of the DNPs used for loading these scaffolds. For PLGA scaffolds, the DNPs were prepared using a radio frequency plasma activated chemical vapor deposition (RF PACVD) method [131], while for the PLLA scaffolds, pristine NanoAmando DNPs (see Section 2.4) were used. These DNPs were much smaller, hydrophobic, and induced cytotoxic effects in Saos-2 cells when added into the cell culture medium. They were probably released from the scaffolds, and may have also increased the hydrophobicity of the scaffolds, which could negatively affect cell functions.
\nDNPs have been also added in materials other than polymers. For example, these nanoparticles were used to increase the corrosion resistance of Mg, i.e., a material promising to construct biodegradable bone implants. Specifically, the corrosion rate of Mg was reduced by 4.5 times, when 5 wt.% of DNPs were uniformly dispersed in the Mg matrix. At the same time, L-929 fibroblasts cultured on the Mg-nanodiamond composites maintained high cell viability and a healthy morphology [132].
\nIt can be concluded that diamond in the form of nanoparticles, nanostructured films and composite scaffolds, particularly nanofibrous scaffolds loaded with DNPs, is an exceptionally promising material for a wide range of biomedical applications. DNPs are suitable for drug and gene delivery, bioimaging, biosensing and also as additives to polymeric scaffolds for bone tissue engineering, particularly those nanofibrous, in order to improve their mechanical properties and increase their bioactivity. Nanodiamond films can be applied for localized drug delivery, construction of biosensors and particularly for bone implant coating due to their favorable effect on cell adhesion, growth and osteogenic differentiation. The cell performance on the nanodiamond films can be modulated by their roughness and topography, e.g., the size and shape of the surface irregularities, by termination with various atoms (e.g., O and H), chemical functional groups and biomolecules and by boron doping. However, free DNPs and DNPs dispersed in a material matrix should be applied with caution because of their higher reactivity with the surrounding environment and potential penetration into cells, which may finally result in their cytotoxicity.
\nOur studies included in this review were supported by the Agency for Healthcare Research, Ministry of Health of the Czech Republic (grant no. 15-32497A) and the Grant Agency of the Czech Republic (grant no. 14-04790S). Mrs. Paula Solon is gratefully acknowledged for her language revision of the manuscript.
\nFood quality is a very broad concept, whose definition presents a complex and dynamic character, which varies according to the time interval and the geographic location.
From the consumer’s point of view, quality is intrinsically linked to health, well-being, and sensory aspect of the products, which makes this concept quite diffuse and subjective [1, 2].
The measurability of the food quality parameter can allow its conversion to be more objective. For producers, the precision in the parameterization of this concept is very important, because the consumer’s perception of quality greatly affects the purchase decision, which in Europe is directly correlated with information subjective [2].
According to Tothill and Stephen [3], a large investment is needed in terms of providing relevant information and industrial marketing practices. This gap has been reduced with the regulation on labeling, requiring the definition of consistent norms and standards, a rigorous food quality control process in order to keep the consumer safe [4], and confident in their decision to purchase the product. This point is in line with Organization for Economic Co-operation and Development (OECD) indications, as there are data indicating that the content of food labels influences consumer behavior more than energy efficiency labeling [5].
Food quality control involves the specification of ingredients and the consequent physical, chemical, and microbiological characterization of food and food products [6].
All food quality control is carried out, using acceptable and well-established methodologies, in order to maintain product characteristics, but is increasingly associated with food safety, for the prevention of chemical and biological hazards that may result in contamination [6, 7].
Since food quality and safety are two increasingly interconnected domains, it is of great value to identify which constituents in food make it unfeasible to consume. These components, called contaminants, are increasingly regulated and controlled, because their improper consumption can interfere with consumer health.
In 1963, a harmonized international collection of food standards, guidelines, and codes of practice was created by the Codex Alimentarius Commission, a joint intergovernmental body of the Food Agriculture Organization (FAO) and the World Health Organization (WHO), to protect consumer health and ensure fair food trade practices.
Since contaminants are defined as substances that are not intentionally added to food and may result from various stages such as production, packaging, transport or storage, or environmental factors, the Codex Committee on Contaminants in Food (CCCF) establishes and endorses maximum allowable levels or guideline levels for naturally occurring contaminants and toxins in food and feed. Codex has established 17 maximum levels for these types of substances, including some hazardous metals, mycotoxins produced by certain fungi, and radionuclides [8].
EU legislation, through its Regulations 315/93/EEC [9], 1881/2006 [10], and amendments, imposes procedures for the determination of contaminants and their maximum levels. Thus, in this issue we will cover three main topics related to the intrinsic quality of food, namely heavy metals, polycyclic aromatic hydrocarbons (PAHs), mycotoxins.
There is a wide variety of synthetic and natural organic pollutants found in the environment, contaminating air, water, soils, and therefore, animals and plants, many of them are used for human food. However, within this vast array are the PAHs that present a great structural diversity, possessing two or more benzene rings. These hydrocarbons can be produced by pyrolysis or incomplete combustion of carbon compounds, such as oil and coal [11, 12].
Highly important and problematic is the fact that this group of aromatic organic compounds can be teratogenic, carcinogenic, and mutagenic, can cause serious problems in human health, and can therefore be used as a marker for the occurrence of polycyclic aromatic hydrocarbons in food [13]. Processing of food, such as smoking, heating, and drying processes, and cooking at high temperatures are the major sources of contamination by PAHs because those processes allow combustion products to come into contact with food. High levels of PAH are found in dried fruits, olive pomace oil, teas, smoked fish, grape seed oil, smoked meat products, fresh mollusks, and condiments [12, 14].
Existence of PAH and its relationship with human health and nutrition is an issue that goes back more than half a century. To protect public health, maximum levels are also necessary for foods where environmental pollution may cause high levels of contamination especially in fish and fishery products that contact contaminated water [15]. The detection, identification, monitoring, and regulation that exist today rely on identities such as the Joint FAO/WHO Expert Committee on Food Additives (JECFA), the European Food Safety Authority (EFSA), the Scientific Committee on Food (SCF), the United States Environmental Protection Agency (U.S. EPA), the International Agency for Research on Cancer (IACR), and the International Programme on Chemical Safety (IPCS), that have joined forces to raise alert to this issue [16].
Based on the evaluation of PAHs, in 2002, the European Union through SCF concluded that 15 PAHs, namely benz[a]anthracene, benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene, benzo[ghi]perylene, benzo[a]pyrene, chrysene, cyclopenta[cd]pyrene, dibenzo[a,h]anthracene, dibenzo[a,e]pyrene, dibenzo[a,h]pyrene, dibenzo[a,i]pyrene, dibenzo[a,l]pyrene, indeno[1,2,3-cd]pyrene, and 5-methylchrysene showed evidence of mutagenicity, genotoxicity [14]. In 2005, EFSA concluded that benzo[a]pyrene could be used as marker to exposure to, and effect of, genotoxic and carcinogenic PAHs. Later, in 2008, the evaluations showed that 50% of the thousands of samples analyzed contained benzo[a]pyrene, but that 30% of the samples that showed carcinogenic properties contained no benzo[a]pyrene. Based on these and other findings, the CONTAM Panel concluded that the risk characterization should be based upon oral carcinogenicity data of eight PAHs, explicitly benzo[a]pyrene, benz[a]anthracene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[ghi]perylene, chrysene, dibenz[a,h]anthracene, and indeno[1,2,3-cd]pyrene (PAH8). These polycyclic aromatic hydrocarbons either individually or in a combination were considered possible indicators of the carcinogenic potency in food. In addition to the effects of the sum of PAH8, the sum of benzo[a]pyrene, chrysene, benz[a]anthracene, and benzo[b]fluoranthene (PAH4), as well as the sum of benzo[a]pyrene and chrysene (PAH2), and the correlation between PAH2, PAH4, and PAH8 were calculated. The CONTAM Panel later concluded that benzo[a]pyrene is not an appropriate indicator for PAH in food and that PAH4 and PAH8 are the most appropriate indicators of PAH in food, with PAH8 not providing much added value compared with PAH4, which are presented in Table 1 [16, 17].
Polycyclic aromatic hydrocarbons (PAH4) and structures.
The foods with maximum levels of PAH4, benzo(a)pyrene, benzo(a)anthracene, benzo(b)fluoranthene and chrysene, above those laid down in EU Regulations 315/93/EEC [9], and 1881/2006 [10] may not be consumed nor used for the edible part of the food. However, recently new data have been collected in order to obtain more useful information on PAHs. An example of this is the new regulated values for powders of food of plant origin used for the preparation of beverages, contained in Regulation 2020/1255 [18], where the maximum thresholds of 10 μg/kg for benzo(a)pyrene and 50 μg/kg for the sum of benzo(a)pyrene, benz(a)anthracene, benzo(b)fluoranthene, and chrysene are established. The same regulation warns of the need to look for new alternative smoking practices to reduce PAH contaminants. This last point is illustrative of the regulators’ concern for maintaining food safety, but also shows the concern for food quality, which has great weight at consumer level and also directly in the production and marketing of smoked products and their derivatives.
European Union also establishment, in Commission Regulation (EC) No 1881/2006 [10], the maximum levels for cadmium (Cd), lead, mercury (Hg), inorganic tin (Sn), and arsenic (As), knowing that the exposure of these heavy metals may lead to oxidation stress, which may induce DNA damage, protein modification, lipid peroxidation, and consequently, toxicity in plants and humans [19, 20]. It is important to mention, from a chemical point of view, that arsenic, although being classified as a nonmetal, is included in the group of heavy metals when it comes to environmental parameters. Consequently, from this point on we will roughly call arsenic a heavy metal [21].
For these metallic elements, the European Commission, through Regulation EC No 1881/2006 [10], sets the maximum levels for certain contaminants in foodstuffs, has fixed the tolerable weekly intake (PTWI) of mercury and lead at 1.6 and 25 μg/kg body weight (bw), respectively, Regulation EC No 488/2014 [22] sets the tolerable weekly intake (TWI) at 2.5 μg/kg bw/week for cadmium, and EC Regulation 2015/1006 [23] annexed to the Regulation EC No 1881/2006 [10], estimated maximum dietary exposures BMDL01 between 0.3 and 8 μg/kg bw/day for arsenic.
Chemical contamination is a consumer concern, but microbiological is the greatest one [24]. The presence of mycotoxins in food and feed is an important concern of the authorities concerning food safety and quality, as their presence may have an important impact on the health of consumers both in the short term and in the long term [25]. Due to its toxicity, the Rapid Alert System for Food and Feed (RASFF) in 2017 considered mycotoxins among the top 10 risk categories in terms of contaminants for food and products [26].
Mycotoxins are products resulting from the secondary metabolic by certain filamentous fungi, they are not essential for their growth and reproduction but can cause biochemical, physiological, and pathological changes in many species [27]. Fungi frequently occur in several crops, such as wheat, corn, soybeans, sorghum, and dried fruits, as well as in derived products used in human food and feed; they can accumulate in maturing products already in the field, or during harvesting, in transportation or also in storage [28, 29, 30].
Depending on microclimatic conditions, such as moisture content, temperature, pH value, and food matrix composition, fungi can produce more than one mycotoxin, and some mycotoxins are produced by more than one fungal species [31, 32]; once produced they can be modified as a result of interactions between fungi and host or during processing, so when humans or animals are exposed to several mycotoxins simultaneously synergistic effects can be observed [25]. Most mycotoxins are low-molecular-weight compounds (less than 1000 Daltons) [33], highly liposoluble, very stable, and can accumulate over time both during crop growth and post-harvest. The European Union authorities produce documentation regarding a comprehensive strategy to be implemented by the food production chain in terms of correct pre-harvest management and post-harvest strategies and also on sanitary conditions as well on the technology and operating conditions in live cycle products [25] to prevent and minimize the contents of mycotoxins as a food contaminant [34].
The main fungi producing mycotoxin belonging to the genera
We can also distinguish between the field toxins, present in the crops, represented mainly by Fusarium deoxynivalelol mycotoxins (DON), zearalenone, fumonisins, and T-2/HT-2 toxins and the storage toxins of which the main ones are aflatoxins (Aflatoxin B1) and ochratoxins (Ochratoxin A).
Human and animals can be exposed to mycotoxins through oral (i.e., dietary consumption) inhalation (dust), and dermal routes, due to their chemical characteristics they are easily absorbed and undergo systemic distribution. In systemic circulation they reach several organs, such as the liver, kidneys, nervous system, and immunological system [33], causing alterations in the immunological response carcinogenicity, teratogenicity, hepatotoxicity, neurotoxicity, nephrotoxicity, reproductive and developmental toxicity, gastrointestinal disorders, among others [32, 35].
Considering that carcinogenic and mutagenic mycotoxin actions are the main health risk in prolonged exposure, Claeys et al. in their systematic review in 2020 [36] classify the main mycotoxins according to International Agency for Research on Cancer (IRCA) criteria into three groups: group 1—The agent is carcinogenic to humans; group 2A—The agent is probably carcinogenic to humans; group 2B—The agent is possibly carcinogenic to humans; group 3—The agent is not classifiable as to its carcinogenic to humans [37]. In Table 2, we gather the IARC toxic effects by Claeys et al. with disease-related problem, fungal species, their occurrence, and the limited daily intake, when studied.
Mycotoxins | Toxic effect | Disease-related problem/targeting system | Fungal species | Frequently contaminated products | Maximum tolerable daily intake |
---|---|---|---|---|---|
Aflatoxins B1, B2, G1, G2 (AFB1, AFB2, AFG1, AFG2) e Aflatoxin M1(AFM1) | IARC Group 1 | Liver cancer, immune system | Cereals (e.g., sorghum, rice, corn, wheat, barely), oil seed (e.g., cotton, rape, sunflower) nuts (e.g., peanuts, groundnut, pistachio), spices (e.g., turmeric, black and red pepper, ginger), meat, fruit juices, eggs, feed, and foods derived from these products. | <1 ng/g [38] | |
Ochratoxin A (OTA) | IARC Group 2B | Renal cancer, liver, cardiovascular and immune systems | Soya bean, nuts, red pepper, cereals, green coffee beans, coffee beans Grapes, red pepper, peanuts, cereals dry ham, salami | 4 ng/kg bw/day [39] | |
Fumonisins B1, B2 (FB1, FB2) | Hepatocarcinoma, stimulation and suppression of the immune system, defects in the neural-tube, nephrotoxicity | Peanut, maize, and grape, feed, and foods derived from these products | 2 μg/kg bw/day [40] | ||
Sterigmatocystin (STC) | Hepatocellular carcinomas, hemangiosarcomas of the liver and pulmonary adenomas | Cheese, spices (e.g., turmeric, black, white, red and chilli, pepper, cumin, and marjoram, caraway), cereals (barely, oat, wheat, corn, rice, buckwheat, soybean, sorghum) and derived from cereals (pastas, breakfast cereals) | 1.5 μg/kg [41] | ||
Fusarin C | Mutagen and immunosuppressive activities (comparable to aflatoxins B1 and sterigmatocystin) Human esophageal cancer [42] | Cereals (wheat, oats, barley, and maize), and fruit (banana and pineapple), lentils, tomato, and pea | No available data | ||
Deoxynivalenol (DON)1 | IARC Group 3 | Vomiting, digestive disorders and oxidative damage. Cytotoxicity and genotoxicity. | Wheat, barley, oats, rye, maize, rice, sorghum and triticale | PMTDI2, PDI3 1 μg/kg bw/day4 [43] | |
Zearalenone (ZEN) | Endocrine disruptor (interaction with estrogen-receptors) | Wheat, barley, oats, rye, and maize | PMTDI 0.5 μg/kg bw/day TDI5 0.25 μg/kg bw/day (20) [44] | ||
Citrinin (CIT) | Nephrotoxic6. Involved in induction of apoptosis though oxidative stress [45] | Mainly in stored grain. Benas, fruit, vegetables herbs and spices | |||
Patulin (PAT) | Gastrointestinal ulceration, immunotoxicity and neurotoxicity | Fruits especially apples silage | PMTDI 0.4 μg/kg bw/day [44] |
Main mycotoxins, toxic effect according to IARC, fungal species, frequently contaminated products, and maximum tolerable daily intake.
A recent study with 3000 Swedish students [47] evaluated the concentrations in urine of various mycotoxins, the data showed a worrying concentration of DON levels.
PMTDI, provisional maximum tolerable daily intake.
PDI, probable daily intake.
bw, body weight per day.
TDI, tolerable daily intake.
The co-occurrence with other mycotoxins, special ochratoxin A, is usually associated with endemic nephropathy.
EU MLs, European maximum levels (EFSA).
The action of mycotoxins as carcinogenic agents is explained by their chemical characteristics, which allow them to easily penetrate both in human and animal cells, reaching the genome, where they can cause mutations in the nucleotide sequence, which can lead to important and permanent alterations in the natural cellular processes of transcription and translation, giving rise to mutations that can exacerbate and deregulate cell growth [32].
According to the above, the study of mycotoxin toxicity goes beyond its carcinogenic and teratogenic effects; its local action in the various systems is of particular importance, aerial topical action at the level of the skin and respiratory system [48, 49, 50, 51, 52]. In the digestive system beyond its acute action at the level of vomiting and diarrhea, the effects on microbiota cause changes in the phylum, genus, and microbiota species level of the various animals exposed. The alterations of microbiota have an important consequence on health, as it causes alterations in the composition of short-chain volatile fatty acids and the sphingolipids normally present in the digestive tract; these alterations have been related to the appearance of several chronic diseases in human [35].
It is necessary to process food under standardized and well-controlled conditions and control each food production cycle and storage chain. Preventive measures capable of reducing contamination to a minimum must be implemented. If contamination occurs, methods to reduce or eliminate mycotoxins should be implemented independently of several parameters such as food or feed properties.
The prevalence of mycotoxin in food and feeds calls for the attention of food safety organizations to create awareness on their control and the need to put in place strict regulations to avoid high levels of exposure. Recent studies show that children may be exposed to mycotoxins from the time of breastfeeding resulting from the prevalence of mycotoxins in the mother’s diet [32].
In fact, food quality is a very broad concept, which, according to Jeantet et al. [53], covers five different components: safety, health, sensory, service, and society, which converge in numerous aspects and criteria. This categorization is much broader than the definition of food quality from the consumer’s point of view, which is much narrower, focusing mainly on sensory and health aspects [2]. Thus, when focusing on food quality, it is inevitable to mention food safety, which, in our view, is one of the fundamental bases for consuming quality food. The implementation and application of regulations and standards of good practice in production and processing, the application of sanitary controls, the design of production and processing facilities, and the continuous monitoring of all processes are elements that help reduce the risk of contamination and hygiene that can seriously compromise public health.
This research was funded by Fundação para a Ciência e a Tecnologia (FCT, Portugal), through projects UIDP/04567/2020 and UIDB/04567/2020. P.P. gratefully acknowledges the support of the CERENA strategic project FCT-UID/ECI/04028/2019.
The authors declare no conflict of interest.
In line with the Principles of Transparency and Best Practice in Scholarly Publishing, below is a more detailed description of IntechOpen's Advertising Policy.
",metaTitle:"Advertising Policy",metaDescription:"IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.",metaKeywords:null,canonicalURL:"/page/advertising-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"1. IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.
\\n\\n2. All advertisements and commercially sponsored publications are independent from editorial decisions.
\\n\\n3. IntechOpen does not endorse any product or service marked as an advertisement on IntechOpen website.
\\n\\n4. IntechOpen has blocked all the inappropriate types of advertising.
\\n\\n5. IntechOpen has blocked advertisement of harmful products or services.
\\n\\n6. Advertisements and editorial content are clearly distinguishable.
\\n\\n7. Editorial decisions will not be influenced by current or potential advertisers and will not be influenced by marketing decisions.
\\n\\n8. Advertisers have no control or influence over the results of searches a user may conduct on the website by keyword or topic search.
\\n\\n9. Types of advertisments:
\\n\\n- Advertisements in the Physical Sciences, Engineering and Technology, and Social Sciences and Humanities sections of the IntechOpen website are programmatic (based on user behaviour such as web pages visited, content viewed, etc.)
\\n\\n- Advertisements in the Life Sciences and Health Sciences sections of the IntechOpen website are programmatic as well as contextual based on the content of the respective books and chapters. IntechOpen's third party partner eHealthcare Solutions (EHS) is a unique marketing platform that specializes in connecting niche audiences with healthcare brands.
\\n\\nYou may view their privacy policy here: https://ehealthcaresolutions.com/privacy-policy/
\\n\\n10. IntechOpen Advertising Sales department makes the decisions about the types of advertisements to include or exclude. Placement of advertising is at the discretion of IntechOpen. IntechOpen retains the right to reject and/or request modifications to the advertisement. An advertisement that is visible online, will be withdrawn from the site at any time if the Editor(s) or Author(s) request its removal.
\\n\\n11. Users can make decisions about accepting advertisements. Users can block all the advertisements by using ad blockers. Users can send all the complaints about advertising to: info@intechopen.com.
\\n\\nPolicy last updated: 2021-04-28
\\n"}]'},components:[{type:"htmlEditorComponent",content:'1. IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.
\n\n2. All advertisements and commercially sponsored publications are independent from editorial decisions.
\n\n3. IntechOpen does not endorse any product or service marked as an advertisement on IntechOpen website.
\n\n4. IntechOpen has blocked all the inappropriate types of advertising.
\n\n5. IntechOpen has blocked advertisement of harmful products or services.
\n\n6. Advertisements and editorial content are clearly distinguishable.
\n\n7. Editorial decisions will not be influenced by current or potential advertisers and will not be influenced by marketing decisions.
\n\n8. Advertisers have no control or influence over the results of searches a user may conduct on the website by keyword or topic search.
\n\n9. Types of advertisments:
\n\n- Advertisements in the Physical Sciences, Engineering and Technology, and Social Sciences and Humanities sections of the IntechOpen website are programmatic (based on user behaviour such as web pages visited, content viewed, etc.)
\n\n- Advertisements in the Life Sciences and Health Sciences sections of the IntechOpen website are programmatic as well as contextual based on the content of the respective books and chapters. IntechOpen's third party partner eHealthcare Solutions (EHS) is a unique marketing platform that specializes in connecting niche audiences with healthcare brands.
\n\nYou may view their privacy policy here: https://ehealthcaresolutions.com/privacy-policy/
\n\n10. IntechOpen Advertising Sales department makes the decisions about the types of advertisements to include or exclude. Placement of advertising is at the discretion of IntechOpen. IntechOpen retains the right to reject and/or request modifications to the advertisement. An advertisement that is visible online, will be withdrawn from the site at any time if the Editor(s) or Author(s) request its removal.
\n\n11. Users can make decisions about accepting advertisements. Users can block all the advertisements by using ad blockers. Users can send all the complaints about advertising to: info@intechopen.com.
\n\nPolicy last updated: 2021-04-28
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6601},{group:"region",caption:"Middle and South America",value:2,count:5906},{group:"region",caption:"Africa",value:3,count:2400},{group:"region",caption:"Asia",value:4,count:12541},{group:"region",caption:"Australia and Oceania",value:5,count:1008},{group:"region",caption:"Europe",value:6,count:17561}],offset:12,limit:12,total:132763},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"1",sort:"dateEndThirdStepPublish",topicId:"13"},books:[{type:"book",id:"11632",title:"Updated Research on Bacteriophages",subtitle:null,isOpenForSubmission:!0,hash:"d34dfa0d5d10511184f97ddaeef9936b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11632.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11797",title:"Clostridium",subtitle:null,isOpenForSubmission:!0,hash:"4cb066b44bb8d4a8b93a627de26e3ebf",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11797.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12145",title:"Yeasts",subtitle:null,isOpenForSubmission:!0,hash:"262e4f155a168f8953bdbe9eb517127d",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12145.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12160",title:"DNA Viruses",subtitle:null,isOpenForSubmission:!0,hash:"5a948eb875a3a62c3abf115c4b5ace84",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12160.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12161",title:"Retroviruses",subtitle:null,isOpenForSubmission:!0,hash:"0cd85c9ce7748f1211685d5add521ebb",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12161.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12162",title:"Helicobacter pylori",subtitle:null,isOpenForSubmission:!0,hash:"1d5df6d5558615ea58030bb3e50ad9dd",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12162.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12163",title:"Escherichia coli",subtitle:null,isOpenForSubmission:!0,hash:"23a6ce1ea4992eca56018c9e85bad165",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12163.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12164",title:"Advances in Probiotics",subtitle:null,isOpenForSubmission:!0,hash:"cc0a28c4126b8d6fd1a5ebead8a0421f",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12164.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12291",title:"Acidophiles",subtitle:null,isOpenForSubmission:!0,hash:"830753134a4180a8e6cf05774aefb9fb",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12291.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12292",title:"New Findings on Human Papillomavirus",subtitle:null,isOpenForSubmission:!0,hash:"d2e7304c38c5e293e509ae9bd1ce8b33",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12292.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12294",title:"Updates on Adenoviruses",subtitle:null,isOpenForSubmission:!0,hash:"9346d0ed80380776aab0a8ac9e503414",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12294.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:41},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:12},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:17},{group:"topic",caption:"Computer and Information Science",value:9,count:16},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:17},{group:"topic",caption:"Engineering",value:11,count:32},{group:"topic",caption:"Environmental Sciences",value:12,count:7},{group:"topic",caption:"Immunology and Microbiology",value:13,count:11},{group:"topic",caption:"Materials Science",value:14,count:11},{group:"topic",caption:"Mathematics",value:15,count:6},{group:"topic",caption:"Medicine",value:16,count:106},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:7},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:11},{group:"topic",caption:"Physics",value:20,count:2},{group:"topic",caption:"Psychology",value:21,count:8},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:32},{group:"topic",caption:"Technology",value:24,count:1},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:11},popularBooks:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4383},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",publishedDate:"May 18th 2022",numberOfDownloads:3340,editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1845,editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1096,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",publishedDate:"May 18th 2022",numberOfDownloads:995,editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3791,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",publishedDate:"May 11th 2022",numberOfDownloads:2982,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",publishedDate:"May 18th 2022",numberOfDownloads:559,editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",publishedDate:"May 18th 2022",numberOfDownloads:546,editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",publishedDate:"May 18th 2022",numberOfDownloads:539,editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",publishedDate:"May 18th 2022",numberOfDownloads:535,editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"124",title:"Vehicle Engineering",slug:"vehicle-engineering",parent:{id:"11",title:"Engineering",slug:"engineering"},numberOfBooks:27,numberOfSeries:0,numberOfAuthorsAndEditors:699,numberOfWosCitations:1077,numberOfCrossrefCitations:777,numberOfDimensionsCitations:1501,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"124",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10969",title:"New Perspectives on Electric Vehicles",subtitle:null,isOpenForSubmission:!1,hash:"ac30eed50ea83d4284f11d72791aa15a",slug:"new-perspectives-on-electric-vehicles",bookSignature:"Marian Găiceanu",coverURL:"https://cdn.intechopen.com/books/images_new/10969.jpg",editedByType:"Edited by",editors:[{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10810",title:"Modern Ship Engineering, Design and Operations",subtitle:null,isOpenForSubmission:!1,hash:"579a9da63aca2172c0f0584328ae91c1",slug:"modern-ship-engineering-design-and-operations",bookSignature:"Carlos Reusser",coverURL:"https://cdn.intechopen.com/books/images_new/10810.jpg",editedByType:"Edited by",editors:[{id:"209816",title:"Dr.",name:"Carlos",middleName:"Alberto",surname:"Reusser",slug:"carlos-reusser",fullName:"Carlos Reusser"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10007",title:"Propulsion",subtitle:"New Perspectives and Applications",isOpenForSubmission:!1,hash:"042ab0c0a8270b1bacf6a8e385601863",slug:"propulsion-new-perspectives-and-applications",bookSignature:"Kazuo Matsuuchi and Hiroaki Hasegawa",coverURL:"https://cdn.intechopen.com/books/images_new/10007.jpg",editedByType:"Edited by",editors:[{id:"42387",title:"Prof.",name:"Kazuo",middleName:null,surname:"Matsuuchi",slug:"kazuo-matsuuchi",fullName:"Kazuo Matsuuchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8840",title:"Intelligent and Efficient Transport Systems",subtitle:"Design, Modelling, Control and Simulation",isOpenForSubmission:!1,hash:"74ab35ec9e85ba37428df986d3a280ff",slug:"intelligent-and-efficient-transport-systems-design-modelling-control-and-simulation",bookSignature:"Truong Quang Dinh",coverURL:"https://cdn.intechopen.com/books/images_new/8840.jpg",editedByType:"Edited by",editors:[{id:"181747",title:"Dr.",name:"Truong Quang",middleName:null,surname:"Dinh",slug:"truong-quang-dinh",fullName:"Truong Quang Dinh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7377",title:"Diesel and Gasoline Engines",subtitle:null,isOpenForSubmission:!1,hash:"dab9fe312a28dd603ac4b21628070d59",slug:"diesel-and-gasoline-engines",bookSignature:"Richard Viskup",coverURL:"https://cdn.intechopen.com/books/images_new/7377.jpg",editedByType:"Edited by",editors:[{id:"103742",title:"Dr.",name:"Richard",middleName:null,surname:"Viskup",slug:"richard-viskup",fullName:"Richard Viskup"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7408",title:"Transportation Systems Analysis and Assessment",subtitle:null,isOpenForSubmission:!1,hash:"1a950b01c0e05eda01c6d2364c7af3aa",slug:"transportation-systems-analysis-and-assessment",bookSignature:"Stefano De Luca, Roberta Di Pace and Boban Djordjevic",coverURL:"https://cdn.intechopen.com/books/images_new/7408.jpg",editedByType:"Edited by",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7198",title:"Propulsion Systems",subtitle:null,isOpenForSubmission:!1,hash:"fd56f1620b0b201a3de0cd3f7e04d15c",slug:"propulsion-systems",bookSignature:"Alessandro Serpi and Mario Porru",coverURL:"https://cdn.intechopen.com/books/images_new/7198.jpg",editedByType:"Edited by",editors:[{id:"217145",title:"Dr.",name:"Alessandro",middleName:null,surname:"Serpi",slug:"alessandro-serpi",fullName:"Alessandro Serpi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6767",title:"New Trends in Electrical Vehicle Powertrains",subtitle:null,isOpenForSubmission:!1,hash:"92949d7c2133b98bbddb02a9037c1dc7",slug:"new-trends-in-electrical-vehicle-powertrains",bookSignature:"Luis Romeral Martínez and Miguel Delgado Prieto",coverURL:"https://cdn.intechopen.com/books/images_new/6767.jpg",editedByType:"Edited by",editors:[{id:"86501",title:"Dr.",name:"Luis",middleName:null,surname:"Romeral Martinez",slug:"luis-romeral-martinez",fullName:"Luis Romeral Martinez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6065",title:"Modern Railway Engineering",subtitle:null,isOpenForSubmission:!1,hash:"77a5fae5e9451d4e52e9f7cd8f39bdcb",slug:"modern-railway-engineering",bookSignature:"Ali Hessami",coverURL:"https://cdn.intechopen.com/books/images_new/6065.jpg",editedByType:"Edited by",editors:[{id:"108303",title:"Prof.",name:"Ali G.",middleName:null,surname:"Hessami",slug:"ali-g.-hessami",fullName:"Ali G. Hessami"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5910",title:"Hybrid Electric Vehicles",subtitle:null,isOpenForSubmission:!1,hash:"92354b49c166c70707d576852b82a9f1",slug:"hybrid-electric-vehicles",bookSignature:"Teresa Donateo",coverURL:"https://cdn.intechopen.com/books/images_new/5910.jpg",editedByType:"Edited by",editors:[{id:"139190",title:"Prof.",name:"Teresa",middleName:null,surname:"Donateo",slug:"teresa-donateo",fullName:"Teresa Donateo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5423",title:"Urban Transport Systems",subtitle:null,isOpenForSubmission:!1,hash:"222b5d90a7014dbff7e33f3dcde6bc1d",slug:"urban-transport-systems",bookSignature:"Hamid Yaghoubi",coverURL:"https://cdn.intechopen.com/books/images_new/5423.jpg",editedByType:"Edited by",editors:[{id:"103965",title:"Dr.",name:"Hamid",middleName:null,surname:"Yaghoubi",slug:"hamid-yaghoubi",fullName:"Hamid Yaghoubi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5299",title:"Modeling and Simulation for Electric Vehicle Applications",subtitle:null,isOpenForSubmission:!1,hash:"42a1e112f18751417613cf1524500467",slug:"modeling-and-simulation-for-electric-vehicle-applications",bookSignature:"Mohamed Amine Fakhfakh",coverURL:"https://cdn.intechopen.com/books/images_new/5299.jpg",editedByType:"Edited by",editors:[{id:"35742",title:"Dr.",name:"Mohamed Amine",middleName:null,surname:"Fakhfakh",slug:"mohamed-amine-fakhfakh",fullName:"Mohamed Amine Fakhfakh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:27,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"13349",doi:"10.5772/14086",title:"High Mn TWIP Steels for Automotive Applications",slug:"high-mn-twip-steels-for-automotive-applications",totalDownloads:12712,totalCrossrefCites:53,totalDimensionsCites:149,abstract:null,book:{id:"19",slug:"new-trends-and-developments-in-automotive-system-engineering",title:"New Trends and Developments in Automotive System Engineering",fullTitle:"New Trends and Developments in Automotive System Engineering"},signatures:"B. C. De Cooman, Kwang-geun Chin and Jinkyung Kim",authors:[{id:"16743",title:"Prof.",name:"Bruno Charles",middleName:null,surname:"De Cooman",slug:"bruno-charles-de-cooman",fullName:"Bruno Charles De Cooman"}]},{id:"13343",doi:"10.5772/13286",title:"Materials in Automotive Application, State of the Art and Prospects",slug:"materials-in-automotive-application-state-of-the-art-and-prospects",totalDownloads:64751,totalCrossrefCites:45,totalDimensionsCites:97,abstract:null,book:{id:"1355",slug:"new-trends-and-developments-in-automotive-industry",title:"New Trends and Developments in Automotive Industry",fullTitle:"New Trends and Developments in Automotive Industry"},signatures:"Elaheh Ghassemieh",authors:[{id:"13695",title:"Dr.",name:"Elaheh",middleName:null,surname:"Ghassemieh",slug:"elaheh-ghassemieh",fullName:"Elaheh Ghassemieh"}]},{id:"42787",doi:"10.5772/55492",title:"Smart Vehicles, Technologies and Main Applications in Vehicular Ad hoc Networks",slug:"smart-vehicles-technologies-and-main-applications-in-vehicular-ad-hoc-networks",totalDownloads:6858,totalCrossrefCites:17,totalDimensionsCites:59,abstract:null,book:{id:"3328",slug:"vehicular-technologies-deployment-and-applications",title:"Vehicular Technologies",fullTitle:"Vehicular Technologies - Deployment and Applications"},signatures:"Anna Maria Vegni, Mauro Biagi and Roberto Cusani",authors:[{id:"19747",title:"Dr.",name:"Anna Maria",middleName:null,surname:"Vegni",slug:"anna-maria-vegni",fullName:"Anna Maria Vegni"},{id:"19749",title:"Prof.",name:"Roberto",middleName:null,surname:"Cusani",slug:"roberto-cusani",fullName:"Roberto Cusani"},{id:"159351",title:"Dr.",name:"Mauro",middleName:null,surname:"Biagi",slug:"mauro-biagi",fullName:"Mauro Biagi"}]},{id:"19571",doi:"10.5772/20271",title:"Electrical Vehicle Design and Modeling",slug:"electrical-vehicle-design-and-modeling",totalDownloads:14304,totalCrossrefCites:45,totalDimensionsCites:56,abstract:null,book:{id:"447",slug:"electric-vehicles-modelling-and-simulations",title:"Electric Vehicles",fullTitle:"Electric Vehicles - Modelling and Simulations"},signatures:"Erik Schaltz",authors:[{id:"38188",title:"MSc",name:"Erik",middleName:null,surname:"Schaltz",slug:"erik-schaltz",fullName:"Erik Schaltz"}]},{id:"19583",doi:"10.5772/17048",title:"DC/DC Converters for Electric Vehicles",slug:"dc-dc-converters-for-electric-vehicles",totalDownloads:23217,totalCrossrefCites:16,totalDimensionsCites:48,abstract:null,book:{id:"447",slug:"electric-vehicles-modelling-and-simulations",title:"Electric Vehicles",fullTitle:"Electric Vehicles - Modelling and Simulations"},signatures:"Monzer Al Sakka, Joeri Van Mierlo and Hamid Gualous",authors:[{id:"27098",title:"Dr.",name:"Monzer",middleName:null,surname:"Al Sakka",slug:"monzer-al-sakka",fullName:"Monzer Al Sakka"},{id:"40637",title:"Prof.",name:"Joeri",middleName:null,surname:"Van Mierlo",slug:"joeri-van-mierlo",fullName:"Joeri Van Mierlo"},{id:"40638",title:"Prof.",name:"Hamid",middleName:null,surname:"Gualous",slug:"hamid-gualous",fullName:"Hamid Gualous"}]}],mostDownloadedChaptersLast30Days:[{id:"19583",title:"DC/DC Converters for Electric Vehicles",slug:"dc-dc-converters-for-electric-vehicles",totalDownloads:23202,totalCrossrefCites:16,totalDimensionsCites:48,abstract:null,book:{id:"447",slug:"electric-vehicles-modelling-and-simulations",title:"Electric Vehicles",fullTitle:"Electric Vehicles - Modelling and Simulations"},signatures:"Monzer Al Sakka, Joeri Van Mierlo and Hamid Gualous",authors:[{id:"27098",title:"Dr.",name:"Monzer",middleName:null,surname:"Al Sakka",slug:"monzer-al-sakka",fullName:"Monzer Al Sakka"},{id:"40637",title:"Prof.",name:"Joeri",middleName:null,surname:"Van Mierlo",slug:"joeri-van-mierlo",fullName:"Joeri Van Mierlo"},{id:"40638",title:"Prof.",name:"Hamid",middleName:null,surname:"Gualous",slug:"hamid-gualous",fullName:"Hamid Gualous"}]},{id:"19571",title:"Electrical Vehicle Design and Modeling",slug:"electrical-vehicle-design-and-modeling",totalDownloads:14300,totalCrossrefCites:43,totalDimensionsCites:56,abstract:null,book:{id:"447",slug:"electric-vehicles-modelling-and-simulations",title:"Electric Vehicles",fullTitle:"Electric Vehicles - Modelling and Simulations"},signatures:"Erik Schaltz",authors:[{id:"38188",title:"MSc",name:"Erik",middleName:null,surname:"Schaltz",slug:"erik-schaltz",fullName:"Erik Schaltz"}]},{id:"64509",title:"Options and Evaluations on Propulsion Systems of LNG Carriers",slug:"options-and-evaluations-on-propulsion-systems-of-lng-carriers",totalDownloads:4195,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"The LNG carriers are undergoing a period of rapid and profound change, with much larger size ships and novel propulsion systems emerging for fulfilling the market trends of LNG shipping industry. There are various proposed propulsion solutions for LNG carriers, ranging from the conventional steam turbine and dual fuel diesel electric propulsion, until more innovative ideas such as slow speed dual fuel diesel engine, combined gas turbine electric & steam system, and hybrid propulsion based on steam turbine and gas engine. Since propulsion system significantly influenced the ship’s capital, emission regulation compliance and navigation safety, the selection of a proper propulsion option with technical feasibility and economic viability for LNG carriers is currently a major concern from the shipping industry and thus must be comprehensively assessed. In this context, this chapter investigated the main characteristics of these propulsion options in terms of BOG treatment, fuel consumption, emission standards compliance, and plant reliability. Furthermore, comparisons among different propulsion system were also carried out and related evaluation was presented.",book:{id:"7198",slug:"propulsion-systems",title:"Propulsion Systems",fullTitle:"Propulsion Systems"},signatures:"Tu Huan, Fan Hongjun, Lei Wei and Zhou Guoqiang",authors:[{id:"265951",title:"Mr.",name:"Huan",middleName:null,surname:"Tu",slug:"huan-tu",fullName:"Huan Tu"}]},{id:"19573",title:"Control of Hybrid Electrical Vehicles",slug:"control-of-hybrid-electrical-vehicles",totalDownloads:15620,totalCrossrefCites:5,totalDimensionsCites:13,abstract:null,book:{id:"447",slug:"electric-vehicles-modelling-and-simulations",title:"Electric Vehicles",fullTitle:"Electric Vehicles - Modelling and Simulations"},signatures:"Gheorghe Livinţ, Vasile Horga, Marcel Răţoi and Mihai Albu",authors:[{id:"25879",title:"Prof.",name:"Gheorghe",middleName:null,surname:"Livint",slug:"gheorghe-livint",fullName:"Gheorghe Livint"},{id:"40500",title:"Dr.",name:"Vasile",middleName:null,surname:"Horga",slug:"vasile-horga",fullName:"Vasile Horga"},{id:"40501",title:"Prof.",name:"Marcel",middleName:null,surname:"Ratoi",slug:"marcel-ratoi",fullName:"Marcel Ratoi"},{id:"40502",title:"Dr.",name:"Mihai",middleName:null,surname:"Albu",slug:"mihai-albu",fullName:"Mihai Albu"}]},{id:"41416",title:"Energy Efficiency of Electric Vehicles",slug:"energy-efficiency-of-electric-vehicles",totalDownloads:7634,totalCrossrefCites:5,totalDimensionsCites:8,abstract:null,book:{id:"3196",slug:"new-generation-of-electric-vehicles",title:"New Generation of Electric Vehicles",fullTitle:"New Generation of Electric Vehicles"},signatures:"Zoran Stevic and Ilija Radovanovic",authors:[{id:"30692",title:"Dr.",name:"Zoran",middleName:"M.",surname:"Stevic",slug:"zoran-stevic",fullName:"Zoran Stevic"}]}],onlineFirstChaptersFilter:{topicId:"124",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"May 13th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"38",title:"Pollution",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",isOpenForSubmission:!0,editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. Begum received her Ph.D. in Environmental Analytical Chemistry from Kanazawa University in 2012. She achieved her Master of Science (M.Sc.) degree with a major in Applied Chemistry and a Bachelor of Science (B.Sc.) in Chemistry, all from the University of Chittagong, Bangladesh. Her work affiliations include Fukushima University, Japan (Visiting Research Fellow, Institute of Environmental Radioactivity: Mar 2016 to present), Southern University Bangladesh (Assistant Professor, Department of Civil Engineering: Jan 2015 to present), and Kanazawa University, Japan (Postdoctoral Fellow, Institute of Science and Engineering: Oct 2012 to Mar 2014; Research fellow, Venture Business Laboratory, Advanced Science and Social Co-Creation Promotion Organization: Apr 2018 to Mar 2021). The research focus of Dr. Zinnat includes the effect of the relative stability of metal-chelator complexes in the environmental remediation process designs and the development of eco-friendly soil washing techniques using biodegradable chelators.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null},{id:"39",title:"Environmental Resilience and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",isOpenForSubmission:!0,editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",slug:"jose-navarro-pedreno",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",biography:"Full professor at University Miguel Hernández of Elche, Spain, previously working at the University of Alicante, Autonomous University of Madrid and Polytechnic University of Valencia. Graduate in Sciences (Chemist), graduate in Geography and History (Geography), master in Water Management, Treatment, master in Fertilizers and Environment and master in Environmental Management; Ph.D. in Environmental Sciences. His research is focused on soil-water and waste-environment relations, mainly on soil-water and soil-waste interactions under different management and waste reuse. His work is reflected in more than 230 communications presented in national and international conferences and congresses, 29 invited lectures from universities, associations and government agencies. Prof. Navarro-Pedreño is also a director of the Ph.D. Program Environment and Sustainability (2012-present) and a member of several societies among which are the Spanish Society of Soil Science, International Union of Soil Sciences, European Society for Soil Conservation, DessertNet and the Spanish Royal Society of Chemistry.",institutionString:"Miguel Hernández University of Elche, Spain",institution:null},editorTwo:null,editorThree:null},{id:"40",title:"Ecosystems and Biodiversity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/40.jpg",isOpenForSubmission:!0,editor:{id:"209149",title:"Prof.",name:"Salustiano",middleName:null,surname:"Mato",slug:"salustiano-mato",fullName:"Salustiano Mato",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLREQA4/Profile_Picture_2022-03-31T10:23:50.png",biography:"Salustiano Mato de la Iglesia (Santiago de Compostela, 1960) is a doctor in biology from the University of Santiago and a Professor of zoology at the Department of Ecology and Animal Biology at the University of Vigo. He has developed his research activity in the fields of fauna and soil ecology, and in the treatment of organic waste, having been the founder and principal investigator of the Environmental Biotechnology Group of the University of Vigo.\r\nHis research activity in the field of Environmental Biotechnology has been focused on the development of novel organic waste treatment systems through composting. The result of this line of work are three invention patents and various scientific and technical publications in prestigious international journals.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorTwo:{id:"60498",title:"Prof.",name:"Josefina",middleName:null,surname:"Garrido",slug:"josefina-garrido",fullName:"Josefina Garrido",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRj1VQAS/Profile_Picture_2022-03-31T10:06:51.jpg",biography:"Josefina Garrido González (Paradela de Abeleda, Ourense 1959), is a doctor in biology from the University of León and a Professor of Zoology at the Department of Ecology and Animal Biology at the University of Vigo. She has focused her research activity on the taxonomy, fauna and ecology of aquatic beetles, in addition to other lines of research such as the conservation of biodiversity in freshwater ecosystems; conservation of protected areas (Red Natura 2000) and assessment of the effectiveness of wetlands as priority areas for the conservation of aquatic invertebrates; studies of water quality in freshwater ecosystems through biological indicators and physicochemical parameters; surveillance and research of vector arthropods and invasive alien species.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorThree:{id:"464288",title:"Dr.",name:"Francisco",middleName:null,surname:"Ramil",slug:"francisco-ramil",fullName:"Francisco Ramil",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003RI7lHQAT/Profile_Picture_2022-03-31T10:15:35.png",biography:"Fran Ramil Blanco (Porto de Espasante, A Coruña, 1960), is a doctor in biology from the University of Santiago de Compostela and a Professor of Zoology at the Department of Ecology and Animal Biology at the University of Vigo. His research activity is linked to the taxonomy, fauna and ecology of marine benthic invertebrates and especially the Cnidarian group. Since 2004, he has been part of the EcoAfrik project, aimed at the study, protection and conservation of biodiversity and benthic habitats in West Africa. He also participated in the study of vulnerable marine ecosystems associated with seamounts in the South Atlantic and is involved in training young African researchers in the field of marine research.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}}},{id:"41",title:"Water Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/41.jpg",isOpenForSubmission:!0,editor:{id:"349630",title:"Dr.",name:"Yizi",middleName:null,surname:"Shang",slug:"yizi-shang",fullName:"Yizi Shang",profilePictureURL:"https://mts.intechopen.com/storage/users/349630/images/system/349630.jpg",biography:"Prof. Dr. Yizi Shang is a pioneering researcher in hydrology and water resources who has devoted his research career to promoting the conservation and protection of water resources for sustainable development. He is presently associate editor of Water International (official journal of the International Water Resources Association). He was also invited to serve as an associate editor for special issues of the Journal of the American Water Resources Association. He has served as an editorial member for international journals such as Hydrology, Journal of Ecology & Natural Resources, and Hydro Science & Marine Engineering, among others. He has chaired or acted as a technical committee member for twenty-five international forums (conferences). Dr. Shang graduated from Tsinghua University, China, in 2010 with a Ph.D. in Engineering. Prior to that, he worked as a research fellow at Harvard University from 2008 to 2009. Dr. Shang serves as a senior research engineer at the China Institute of Water Resources and Hydropower Research (IWHR) and was awarded as a distinguished researcher at National Taiwan University in 2017.",institutionString:"China Institute of Water Resources and Hydropower Research",institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:0,paginationItems:[]},overviewPagePublishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"10843",title:"Persistent Organic Pollutants (POPs)",subtitle:"Monitoring, Impact and Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10843.jpg",slug:"persistent-organic-pollutants-pops-monitoring-impact-and-treatment",publishedDate:"April 13th 2022",editedByType:"Edited by",bookSignature:"Mohamed Nageeb Rashed",hash:"f5b1589f0a990b6114fef2dadc735dd9",volumeInSeries:1,fullTitle:"Persistent Organic Pollutants (POPs) - Monitoring, Impact and Treatment",editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed",profilePictureURL:"https://mts.intechopen.com/storage/users/63465/images/system/63465.gif",biography:"Prof. Mohamed Nageeb Rashed is Professor of Analytical and Environmental Chemistry and former vice-dean for environmental affairs, Faculty of Science, Aswan University, Egypt. He received his Ph.D. in Environmental Analytical Chemistry from Assiut University, Egypt, in 1989. His research interest is in analytical and environmental chemistry with special emphasis on: (1) monitoring and assessing biological trace elements and toxic metals in human blood, urine, water, crops, vegetables, and medicinal plants; (2) relationships between environmental heavy metals and human diseases; (3) uses of biological indicators for monitoring water pollution; (4) environmental chemistry of lakes, rivers, and well water; (5) water and wastewater treatment by adsorption and photocatalysis techniques; (6) soil and water pollution monitoring, control, and treatment; and (7) advanced oxidation treatment. Prof. Rashed has supervised several MSc and Ph.D. theses in the field of analytical and environmental chemistry. He served as an examiner for several Ph.D. theses in analytical chemistry in India, Kazakhstan, and Botswana. He has published about ninety scientific papers in peer-reviewed international journals and several papers in national and international conferences. He participated as an invited speaker at thirty international conferences. Prof. Rashed is the editor-in-chief and an editorial board member for several international journals in the fields of chemistry and environment. He is a member of several national and international societies. He received the Egyptian State Award for Environmental Research in 2001 and the Aswan University Merit Award for Basic Science in 2020. Prof. Rashed was recognized in Stanford University’s list of the World’s Top 2% Scientists in 2020 and 2021.",institutionString:null,institution:{name:"Aswan University",institutionURL:null,country:{name:"Egypt"}}}]}]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11601",title:"Econometrics - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11601.jpg",hash:"bc8ab49e2cf436c217a49ca8c12a22eb",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 13th 2022",isOpenForSubmission:!0,editors:[{id:"452331",title:"Dr.",name:"Brian",surname:"Sloboda",slug:"brian-sloboda",fullName:"Brian Sloboda"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:19,paginationItems:[{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81271",title:"The Diversity of Parvovirus Telomeres",doi:"10.5772/intechopen.102684",signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"79909",title:"Cryopreservation Methods and Frontiers in the Art of Freezing Life in Animal Models",doi:"10.5772/intechopen.101750",signatures:"Feda S. Aljaser",slug:"cryopreservation-methods-and-frontiers-in-the-art-of-freezing-life-in-animal-models",totalDownloads:170,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"79782",title:"Avian Reproduction",doi:"10.5772/intechopen.101185",signatures:"Kingsley Omogiade Idahor",slug:"avian-reproduction",totalDownloads:151,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Kingsley O.",surname:"Idahor"}],book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"78802",title:"Intraovarian Gestation in Viviparous Teleosts: Unique Type of Gestation among Vertebrates",doi:"10.5772/intechopen.100267",signatures:"Mari-Carmen Uribe, Gabino De la Rosa-Cruz, Adriana García-Alarcón and Juan Carlos Campuzano-Caballero",slug:"intraovarian-gestation-in-viviparous-teleosts-unique-type-of-gestation-among-vertebrates",totalDownloads:184,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"79209",title:"Virtual Physiology: A Tool for the 21st Century",doi:"10.5772/intechopen.99671",signatures:"Carmen Nóbrega, Maria Aires Pereira, Catarina Coelho, Isabel Brás, Ana Cristina Mega, Carla Santos, Fernando Esteves, Rita Cruz, Ana I. Faustino-Rocha, Paula A. Oliveira, João Mesquita and Helena Vala",slug:"virtual-physiology-a-tool-for-the-21st-century",totalDownloads:137,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78849",title:"Application of Vermicompost Fertilizer in Aquaculture Nutrition: Review",doi:"10.5772/intechopen.100326",signatures:"Sonnia Nzilani Musyoka and Rita Nairuti",slug:"application-of-vermicompost-fertilizer-in-aquaculture-nutrition-review",totalDownloads:67,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Nutrition - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11416.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"78617",title:"Doppler Ultrasound in the Reproduction of Mares",doi:"10.5772/intechopen.98951",signatures:"Camila Silva Costa Ferreira and Rita de Cássia Lima Morais",slug:"doppler-ultrasound-in-the-reproduction-of-mares",totalDownloads:123,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"78543",title:"Pulmonary Vein: Embryology, Anatomy, Function and Disease",doi:"10.5772/intechopen.100051",signatures:"Chan I-Ping and Hsueh Tung",slug:"pulmonary-vein-embryology-anatomy-function-and-disease",totalDownloads:171,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78564",title:"Anatomy of the Rhesus Monkey (Macaca mulatta): The Essentials for the Biomedical Researcher",doi:"10.5772/intechopen.99067",signatures:"Christophe Casteleyn and Jaco Bakker",slug:"anatomy-of-the-rhesus-monkey-macaca-mulatta-the-essentials-for-the-biomedical-researcher",totalDownloads:308,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}}]},subseriesFiltersForOFChapters:[{caption:"Animal Nutrition",value:20,count:1,group:"subseries"},{caption:"Animal Reproductive Biology and Technology",value:28,count:7,group:"subseries"},{caption:"Animal Science",value:19,count:11,group:"subseries"}],publishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"9883",title:"Biosensors",subtitle:"Current and Novel Strategies for Biosensing",coverURL:"https://cdn.intechopen.com/books/images_new/9883.jpg",slug:"biosensors-current-and-novel-strategies-for-biosensing",publishedDate:"May 5th 2021",editedByType:"Edited by",bookSignature:"Luis Jesús Villarreal-Gómez and Ana Leticia Iglesias",hash:"028f3e5dbf9c32590183ac4b4f0a2825",volumeInSeries:11,fullTitle:"Biosensors - Current and Novel Strategies for Biosensing",editors:[{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9959",title:"Biomedical Signal and Image Processing",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9959.jpg",slug:"biomedical-signal-and-image-processing",publishedDate:"April 14th 2021",editedByType:"Edited by",bookSignature:"Yongxia Zhou",hash:"22b87a09bd6df065d78c175235d367c8",volumeInSeries:10,fullTitle:"Biomedical Signal and Image Processing",editors:[{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou",profilePictureURL:"https://mts.intechopen.com/storage/users/259308/images/system/259308.jpeg",institutionString:"University of Southern California",institution:{name:"University of Southern California",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9973",title:"Data Acquisition",subtitle:"Recent Advances and Applications in Biomedical Engineering",coverURL:"https://cdn.intechopen.com/books/images_new/9973.jpg",slug:"data-acquisition-recent-advances-and-applications-in-biomedical-engineering",publishedDate:"March 17th 2021",editedByType:"Edited by",bookSignature:"Bartłomiej Płaczek",hash:"75ea6cdd241216c9db28aa734ab34446",volumeInSeries:9,fullTitle:"Data Acquisition - Recent Advances and Applications in Biomedical Engineering",editors:[{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",institutionString:"University of Silesia",institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9905",title:"Biometric Systems",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9905.jpg",slug:"biometric-systems",publishedDate:"February 10th 2021",editedByType:"Edited by",bookSignature:"Muhammad Sarfraz",hash:"c730560dd2e3837a03407b3a86b0ef2a",volumeInSeries:8,fullTitle:"Biometric Systems",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",institutionString:"Kuwait University",institution:{name:"Kuwait University",institutionURL:null,country:{name:"Kuwait"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8622",title:"Peptide Synthesis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8622.jpg",slug:"peptide-synthesis",publishedDate:"December 18th 2019",editedByType:"Edited by",bookSignature:"Jaya T. Varkey",hash:"de9fa48c5248dbfb581825b8c74f5623",volumeInSeries:0,fullTitle:"Peptide Synthesis",editors:[{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",institutionString:"St. Teresa’s College",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7497",title:"Computer Vision in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7497.jpg",slug:"computer-vision-in-dentistry",publishedDate:"September 18th 2019",editedByType:"Edited by",bookSignature:"Monika Elzbieta Machoy",hash:"1e9812cebd46ef9e28257f3e96547f6a",volumeInSeries:7,fullTitle:"Computer Vision in Dentistry",editors:[{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8633",title:"Novel Diagnostic Methods in Ophthalmology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8633.jpg",slug:"novel-diagnostic-methods-in-ophthalmology",publishedDate:"September 4th 2019",editedByType:"Edited by",bookSignature:"Anna Nowinska",hash:"da2c90e8db647ead30504defce3fb5d3",volumeInSeries:6,fullTitle:"Novel Diagnostic Methods in Ophthalmology",editors:[{id:"261466",title:"Dr.",name:"Anna",middleName:"Karolina",surname:"Nowińska",slug:"anna-nowinska",fullName:"Anna Nowińska",profilePictureURL:"https://mts.intechopen.com/storage/users/261466/images/system/261466.jpeg",institutionString:"Medical University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7437",title:"Nanomedicines",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7437.jpg",slug:"nanomedicines",publishedDate:"February 13th 2019",editedByType:"Edited by",bookSignature:"Muhammad Akhyar Farrukh",hash:"0e1f5f6258f074c533976c4f4d248568",volumeInSeries:5,fullTitle:"Nanomedicines",editors:[{id:"63182",title:"Dr.",name:"Muhammad Akhyar",middleName:null,surname:"Farrukh",slug:"muhammad-akhyar-farrukh",fullName:"Muhammad Akhyar Farrukh",profilePictureURL:"https://mts.intechopen.com/storage/users/63182/images/system/63182.png",institutionString:"Forman Christian College",institution:{name:"Forman Christian College",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",institutionString:"University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",value:9,count:1},{group:"subseries",caption:"Bioinspired Technology and Biomechanics",value:8,count:2},{group:"subseries",caption:"Bioinformatics and Medical Informatics",value:7,count:9}],publicationYearFilters:[{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:3}],authors:{paginationCount:33,paginationItems:[{id:"424419",title:"Dr.",name:"Matthew",middleName:"Ayorinde",surname:"Ayorinde Adebayo",slug:"matthew-ayorinde-adebayo",fullName:"Matthew Ayorinde Adebayo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/424419/images/17356_n.jpg",biography:null,institutionString:null,institution:null},{id:"354033",title:"Dr.",name:"Ahmed",middleName:null,surname:"Nasri",slug:"ahmed-nasri",fullName:"Ahmed Nasri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Carthage",country:{name:"Tunisia"}}},{id:"435702",title:"Dr.",name:"Amel",middleName:null,surname:"Hannachi",slug:"amel-hannachi",fullName:"Amel Hannachi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Carthage",country:{name:"Tunisia"}}},{id:"420857",title:"Prof.",name:"Ezzeddine",middleName:null,surname:"Mahmoudi",slug:"ezzeddine-mahmoudi",fullName:"Ezzeddine Mahmoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Carthage",country:{name:"Tunisia"}}},{id:"420856",title:"Prof.",name:"Hamouda",middleName:null,surname:"Beyrem",slug:"hamouda-beyrem",fullName:"Hamouda Beyrem",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Carthage",country:{name:"Tunisia"}}},{id:"435703",title:"Dr.",name:"Hary",middleName:null,surname:"Demey",slug:"hary-demey",fullName:"Hary Demey",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Polytechnic University of Cartagena",country:{name:"Spain"}}},{id:"425026",title:"Mr.",name:"Kholofelo",middleName:null,surname:"Clifford Malematja",slug:"kholofelo-clifford-malematja",fullName:"Kholofelo Clifford Malematja",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Tshwane University of Technology",country:{name:"South Africa"}}},{id:"435701",title:"Dr.",name:"Mohamed",middleName:null,surname:"Allouche",slug:"mohamed-allouche",fullName:"Mohamed Allouche",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Carthage",country:{name:"Tunisia"}}},{id:"420855",title:"Prof.",name:"Patricia",middleName:null,surname:"Aïssa",slug:"patricia-aissa",fullName:"Patricia Aïssa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Carthage",country:{name:"Tunisia"}}},{id:"435699",title:"Dr.",name:"Takoua",middleName:null,surname:"Mhadhbi",slug:"takoua-mhadhbi",fullName:"Takoua Mhadhbi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Carthage",country:{name:"Tunisia"}}},{id:"442300",title:"Prof.",name:"Véronique",middleName:null,surname:"Perrier",slug:"veronique-perrier",fullName:"Véronique Perrier",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Montpellier",country:{name:"France"}}},{id:"445179",title:"Mr.",name:"Aman",middleName:null,surname:"Jaiswal",slug:"aman-jaiswal",fullName:"Aman Jaiswal",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Science Education and Research Mohali",country:{name:"India"}}},{id:"445178",title:"Mr.",name:"Dhiraj",middleName:null,surname:"Dutta",slug:"dhiraj-dutta",fullName:"Dhiraj Dutta",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Defence Research Laboratory",country:{name:"India"}}},{id:"445180",title:"Dr.",name:"Rama",middleName:null,surname:"Dubey",slug:"rama-dubey",fullName:"Rama Dubey",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Defence Research Laboratory",country:{name:"India"}}},{id:"424992",title:"Dr.",name:"Mohamed",middleName:null,surname:"Helal",slug:"mohamed-helal",fullName:"Mohamed Helal",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Institute of Oceanography and Fisheries",country:{name:"Egypt"}}},{id:"428329",title:"Mr.",name:"Collet",middleName:null,surname:"Maswanganyi",slug:"collet-maswanganyi",fullName:"Collet Maswanganyi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Limpopo",country:{name:"South Africa"}}},{id:"428546",title:"MSc.",name:"Ndivhuwo",middleName:null,surname:"Shumbula",slug:"ndivhuwo-shumbula",fullName:"Ndivhuwo Shumbula",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"352155",title:"Dr.",name:"Poslet",middleName:"Morgan",surname:"Shumbula",slug:"poslet-shumbula",fullName:"Poslet Shumbula",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Limpopo",country:{name:"South Africa"}}},{id:"435064",title:"Dr.",name:"Mohammadtaghi",middleName:null,surname:"Vakili",slug:"mohammadtaghi-vakili",fullName:"Mohammadtaghi Vakili",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Yangtze Normal University",country:{name:"China"}}},{id:"437268",title:"Dr.",name:"Linda Lunga",middleName:null,surname:"Sibali",slug:"linda-lunga-sibali",fullName:"Linda Lunga Sibali",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"437269",title:"Dr.",name:"Peter P.",middleName:null,surname:"Ndibewu",slug:"peter-p.-ndibewu",fullName:"Peter P. Ndibewu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"424106",title:"Ph.D. Student",name:"Siyabonga",middleName:null,surname:"Aubrey Mhlongo",slug:"siyabonga-aubrey-mhlongo",fullName:"Siyabonga Aubrey Mhlongo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"424233",title:"Ph.D. Student",name:"Ifeoluwa Oluwafunmilayo",middleName:null,surname:"Daramola",slug:"ifeoluwa-oluwafunmilayo-daramola",fullName:"Ifeoluwa Oluwafunmilayo Daramola",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"446429",title:"Dr.",name:"Dev Vrat",middleName:null,surname:"Kamboj",slug:"dev-vrat-kamboj",fullName:"Dev Vrat Kamboj",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"425585",title:"Dr.",name:"NISHA",middleName:null,surname:"GAUR",slug:"nisha-gaur",fullName:"NISHA GAUR",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"226635",title:"Prof.",name:"Amany",middleName:null,surname:"El-Sikaily",slug:"amany-el-sikaily",fullName:"Amany El-Sikaily",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"435668",title:"Dr.",name:"Sara",middleName:null,surname:"Ghanem",slug:"sara-ghanem",fullName:"Sara Ghanem",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"426808",title:"Associate Prof.",name:"Yesim",middleName:null,surname:"Gucbilmez",slug:"yesim-gucbilmez",fullName:"Yesim Gucbilmez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"423291",title:"Assistant Prof.",name:"Giovanni",middleName:null,surname:"Cagnetta",slug:"giovanni-cagnetta",fullName:"Giovanni Cagnetta",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]}},subseries:{item:{id:"22",type:"subseries",title:"Applied Intelligence",keywords:"Machine Learning, Intelligence Algorithms, Data Science, Artificial Intelligence, Applications on Applied Intelligence",scope:"This field is the key in the current industrial revolution (Industry 4.0), where the new models and developments are based on the knowledge generation on applied intelligence. The motor of the society is the industry and the research of this topic has to be empowered in order to increase and improve the quality of our lives.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11418,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"13633",title:"Prof.",name:"Abdelhamid",middleName:null,surname:"Mellouk",slug:"abdelhamid-mellouk",fullName:"Abdelhamid Mellouk",profilePictureURL:"https://mts.intechopen.com/storage/users/13633/images/1567_n.jpg",institutionString:null,institution:{name:"Paris 12 Val de Marne University",institutionURL:null,country:{name:"France"}}},{id:"109268",title:"Dr.",name:"Ali",middleName:null,surname:"Al-Ataby",slug:"ali-al-ataby",fullName:"Ali Al-Ataby",profilePictureURL:"https://mts.intechopen.com/storage/users/109268/images/7410_n.jpg",institutionString:null,institution:{name:"University of Liverpool",institutionURL:null,country:{name:"United Kingdom"}}},{id:"3807",title:"Dr.",name:"Carmelo",middleName:"Jose Albanez",surname:"Bastos-Filho",slug:"carmelo-bastos-filho",fullName:"Carmelo Bastos-Filho",profilePictureURL:"https://mts.intechopen.com/storage/users/3807/images/624_n.jpg",institutionString:null,institution:{name:"Universidade de Pernambuco",institutionURL:null,country:{name:"Brazil"}}},{id:"38850",title:"Dr.",name:"Efren",middleName:null,surname:"Gorrostieta Hurtado",slug:"efren-gorrostieta-hurtado",fullName:"Efren Gorrostieta Hurtado",profilePictureURL:"https://mts.intechopen.com/storage/users/38850/images/system/38850.jpg",institutionString:null,institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},{id:"239041",title:"Prof.",name:"Yang",middleName:null,surname:"Yi",slug:"yang-yi",fullName:"Yang Yi",profilePictureURL:"https://mts.intechopen.com/storage/users/239041/images/system/239041.jpeg",institutionString:"Virginia Tech",institution:{name:"Virginia Tech",institutionURL:null,country:{name:"United States of America"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},publishedBooks:{paginationCount:8,paginationItems:[{type:"book",id:"7999",title:"Free Radical Medicine and Biology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7999.jpg",slug:"free-radical-medicine-and-biology",publishedDate:"July 15th 2020",editedByType:"Edited by",bookSignature:"Kusal Das, Swastika Das, Mallanagouda Shivanagouda Biradar, Varaprasad Bobbarala and S. Subba Tata",hash:"083e5d427097d368a3f8a02bd6c76bf8",volumeInSeries:10,fullTitle:"Free Radical Medicine and Biology",editors:[{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8762",title:"Melatonin",subtitle:"The Hormone of Darkness and its Therapeutic Potential and Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/8762.jpg",slug:"melatonin-the-hormone-of-darkness-and-its-therapeutic-potential-and-perspectives",publishedDate:"June 24th 2020",editedByType:"Edited by",bookSignature:"Marilena Vlachou",hash:"bfbc5538173f11acb0f9549a85b70489",volumeInSeries:9,fullTitle:"Melatonin - The Hormone of Darkness and its Therapeutic Potential and Perspectives",editors:[{id:"246279",title:"Associate Prof.",name:"Marilena",middleName:null,surname:"Vlachou",slug:"marilena-vlachou",fullName:"Marilena Vlachou",profilePictureURL:"https://mts.intechopen.com/storage/users/246279/images/system/246279.jpg",institutionString:"National and Kapodistrian University of Athens",institution:{name:"National and Kapodistrian University of Athens",institutionURL:null,country:{name:"Greece"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8002",title:"Tumor Progression and Metastasis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8002.jpg",slug:"tumor-progression-and-metastasis",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Ahmed Lasfar and Karine Cohen-Solal",hash:"db17b0fe0a9b6e80ff02b81a93bafa4e",volumeInSeries:8,fullTitle:"Tumor Progression and Metastasis",editors:[{id:"32546",title:"Dr.",name:"Ahmed",middleName:null,surname:"Lasfar",slug:"ahmed-lasfar",fullName:"Ahmed Lasfar",profilePictureURL:"https://mts.intechopen.com/storage/users/32546/images/system/32546.png",institutionString:"Rutgers, The State University of New Jersey",institution:{name:"Rutgers, The State University of New Jersey",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6897",title:"Biophysical Chemistry",subtitle:"Advance Applications",coverURL:"https://cdn.intechopen.com/books/images_new/6897.jpg",slug:"biophysical-chemistry-advance-applications",publishedDate:"February 19th 2020",editedByType:"Edited by",bookSignature:"Mohammed A. A. Khalid",hash:"0ad18ab382e2ffb9ff202d15282297eb",volumeInSeries:7,fullTitle:"Biophysical Chemistry - Advance Applications",editors:[{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",institutionString:"Taif University",institution:{name:"Taif University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8008",title:"Antioxidants",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8008.jpg",slug:"antioxidants",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Emad Shalaby",hash:"76361b4061e830906267933c1c670027",volumeInSeries:5,fullTitle:"Antioxidants",editors:[{id:"63600",title:"Prof.",name:"Emad",middleName:null,surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby",profilePictureURL:"https://mts.intechopen.com/storage/users/63600/images/system/63600.png",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",institutionString:"University of Pécs",institution:{name:"University of Pecs",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7264",title:"Calcium and Signal Transduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7264.jpg",slug:"calcium-and-signal-transduction",publishedDate:"October 24th 2018",editedByType:"Edited by",bookSignature:"John N. Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"4",title:"Fungal Infectious Diseases",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:287,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/429168",hash:"",query:{},params:{id:"429168"},fullPath:"/profiles/429168",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()