Mechanical properties of assigned materials.
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"5906",leadTitle:null,fullTitle:"Pathophysiology - Altered Physiological States",title:"Pathophysiology",subtitle:"Altered Physiological States",reviewType:"peer-reviewed",abstract:"Pathophysiology is the convergence of pathology (the discipline of observed changes in a diseased state) with physiology (the mechanisms of systems operation). It represents the functional changes that occur because of injury or disease. This volume provides state-of-the-art up-to-date literature reviews on pathophysiological processes in a number of disease states. The book is organised methodically in a head-to-toe systems approach examining aspects of neuropathophysiology, endocrine pathophysiology, structural biology, renal pathophysiology and genitourinary pathophysiology. This short volume on pathophysiology is intended for general medical and biomedical students at both undergraduate and postgraduate levels. In addition, it is a useful short update of recent advances in research and translational biology to those working in academia or healthcare science.",isbn:"978-1-78923-181-6",printIsbn:"978-1-78923-180-9",pdfIsbn:"978-1-83881-255-3",doi:"10.5772/65994",price:119,priceEur:129,priceUsd:155,slug:"pathophysiology-altered-physiological-states",numberOfPages:224,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"b277409ee570d9c47798ff5b42638603",bookSignature:"David C. Gaze",publishedDate:"May 30th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/5906.jpg",numberOfDownloads:13706,numberOfWosCitations:7,numberOfCrossrefCitations:13,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:21,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:41,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"January 9th 2017",dateEndSecondStepPublish:"January 30th 2017",dateEndThirdStepPublish:"September 18th 2017",dateEndFourthStepPublish:"October 18th 2017",dateEndFifthStepPublish:"December 18th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"71983",title:"Dr.",name:"David C.",middleName:null,surname:"Gaze",slug:"david-c.-gaze",fullName:"David C. Gaze",profilePictureURL:"https://mts.intechopen.com/storage/users/71983/images/system/71983.jpg",biography:"Dr. David Gaze is currently Senior Lecturer in Chemical Pathology at the University of Westminster, London, UK.\nDr. Gaze has academic research interests in general clinical biochemistry and hematology but is specifically interested in the development and clinical utility of cardiac biomarkers for the detection of cardiovascular diseases. His special interest is in chronic kidney disease patients who develop cardiorenal syndrome.\nDr. Gaze has authored and co-authored more than 150 peer-reviewed papers and in excess of 200 conferences abstracts. He has contributed five book chapters to cardiovascular-related textbooks as well as a volume on cardiac troponin.\nDr. Gaze is a peer reviewer for 25 medical journals. He is the commissioning editor for review articles for the Annals of Clinical Biochemistry & Laboratory Medicine and is Co-editor-in-chief of Practical Laboratory Medicine.",institutionString:"University of Westminster",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"6",institution:{name:"University of Westminster",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1104",title:"Pathophysiology",slug:"medicine-pathology-pathophysiology"}],chapters:[{id:"60898",title:"Body Dysmorphic Disorder: Characteristics, Psychopathology, Clinical Associations, and Influencing Factors",doi:"10.5772/intechopen.76446",slug:"body-dysmorphic-disorder-characteristics-psychopathology-clinical-associations-and-influencing-facto",totalDownloads:1409,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:1,abstract:"Body dysmorphic disorder (BDD) is defined by a recurring and persistent concern characterized by psychic suffering caused by a possible physical imperfection in appearance. It is a severe psychiatric condition, duly confirmed by neuroanatomical findings, very peculiar repetitive behaviors, and specific personalities. The prevalence of BDD is increasing around the world and differs between countries, because of cultural differences and different health-care systems. This increase is worrying because BDD is a pathology that presents comorbidity like severe depression, suicidal ideation, and functional and social impairment. However, BDD is an unrecognized and often not diagnosed in our society. Many patients are ashamed of their complaints and do not usually seek psychiatric help with ease, and unfortunately, they seek help in cosmetic and surgical treatments to improve their appearance, and these professionals are not yet prepared to assist in the diagnosis of this disorder. Therefore, this chapter presents not only the psychopathology of BDD but also its associations with other pathologies and their main factors of influence. Finally, we present a clinical experience with a detailed description of a clinical case. The aim is to contribute to the diagnosis and treatment of this pathology and also to future research that may benefit society and these patients.",signatures:"Patricia Tatiana Soler, Cristina Michiko Harada Ferreira, Jefferson da\nSilva Novaes and Helder Miguel Fernandes",downloadPdfUrl:"/chapter/pdf-download/60898",previewPdfUrl:"/chapter/pdf-preview/60898",authors:[{id:"110403",title:"Prof.",name:"Helder",surname:"Fernandes",slug:"helder-fernandes",fullName:"Helder Fernandes"},{id:"215707",title:"MSc.",name:"Patricia Tatiana",surname:"Soler",slug:"patricia-tatiana-soler",fullName:"Patricia Tatiana Soler"},{id:"215708",title:"Prof.",name:"Jefferson Da Silva",surname:"Novaes",slug:"jefferson-da-silva-novaes",fullName:"Jefferson Da Silva Novaes"},{id:"215709",title:"Dr.",name:"Cristina Michiko Harada",surname:"Ferreira",slug:"cristina-michiko-harada-ferreira",fullName:"Cristina Michiko Harada Ferreira"}],corrections:null},{id:"57416",title:"Alteration in Nasal Cycle Rhythm as an Index of the Diseased Condition",doi:"10.5772/intechopen.70599",slug:"alteration-in-nasal-cycle-rhythm-as-an-index-of-the-diseased-condition",totalDownloads:1367,totalCrossrefCites:5,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Breathing is the vital function based on the conductance of air through a system of branching tubes that taper off and eventually connect to the alveoli. Nose act as an interface between atmospheric air and lower respiratory system, constitute the moist respiratory epithelium, which performs various vital physiological functions like filtering the inspired air, warming, and humidifying. Several anatomical and physiological factors are responsible for the passage of airflow in two nostrils, which are asymmetric in nature. The inequality airflow passage in both the nostrils exists for a specific duration. This phenomenon of altering asymmetrical airflow from one nasal passage to the other is called ‘nasal cycle’. For every regular interval of time period, the swap of predominant nasal airflow between two nostrils determines the nasal patency. This cycle is controlled by the central regulator located at hypothalamus by coordinating the autonomic nervous system that comprises sympathetic and parasympathetic nerves that clog the nasal mucosa. The nostril decongest when the sympathetic nerves in one nostril become active. In this biorhythm, if the sympathetic nerves of one nostril drop, immediately the parasympathetic nerves take over, so that the other nostril congests. It is unclear why these cycles exist but the total nasal airway resistance is almost unchanged. There are a range of activities and reflexes, which can affect the nasal airway. This biorhythm is categorized under ultradian cycle since the mean duration of nasal cycle is about two and a half hours. In this study, it observed changes in nasal airflow duration, pattern, and rhythm that correspond to various disease states in human.",signatures:"Elangovan Muthu Kumaran",downloadPdfUrl:"/chapter/pdf-download/57416",previewPdfUrl:"/chapter/pdf-preview/57416",authors:[{id:"205096",title:"Dr.",name:"E.",surname:"Muthu Kumaran",slug:"e.-muthu-kumaran",fullName:"E. Muthu Kumaran"}],corrections:null},{id:"56909",title:"Changes in the Striatal Network Connectivity in Parkinsonian and Dyskinetic Rodent Models",doi:"10.5772/intechopen.70601",slug:"changes-in-the-striatal-network-connectivity-in-parkinsonian-and-dyskinetic-rodent-models",totalDownloads:927,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"In Parkinson’s disease, there is a loss of dopaminergic innervation in the basal ganglia. The lack of dopamine produces substantial changes in neural plasticity and generates pathological activity patterns between basal ganglia nuclei. The treatment to relieve Parkinsonism is the administration of levodopa. However, the treatment produces dyskinesia. The question to answer is how the interactions between neurons change in the brain microcircuits under these pathological conditions. Calcium imaging is a way to record the activity of dozens of neurons simultaneously with single-cell resolution in brain slices from rodents. We studied these interactions in the striatum, since it is the nucleus of the basal ganglia that receives the major dopaminergic innervation. We used network analysis, where each active neuron is taken as a node and its coactivity with other neurons is taken as its functional connections. The network obtained represents the functional connectome of the striatal microcircuit, which can be characterized with a small set of parameters taken from graph theory. We then quantify the pathological changes at the functional histological scale and the differences between normal and pathological conditions.",signatures:"Jesús Pérez-Ortega and José Bargas",downloadPdfUrl:"/chapter/pdf-download/56909",previewPdfUrl:"/chapter/pdf-preview/56909",authors:[{id:"41529",title:"Dr.",name:"José",surname:"Bargas",slug:"jose-bargas",fullName:"José Bargas"},{id:"201877",title:"Dr.",name:"Jesús",surname:"Pérez-Ortega",slug:"jesus-perez-ortega",fullName:"Jesús Pérez-Ortega"}],corrections:null},{id:"55194",title:"Transthyretin in the Evaluation of Health and Disease in Human and Veterinary Medicine",doi:"10.5772/intechopen.68725",slug:"transthyretin-in-the-evaluation-of-health-and-disease-in-human-and-veterinary-medicine",totalDownloads:1084,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Transthyretin (also known as prealbumin) is an important transport protein, which plays an essential role in the binding of thyroid hormones and retinol with varying affinities in mammalian, as well as avian species. The determination of transthyretin concentrations may be used as a diagnostic tool for some disease conditions in humans, but is more often used as a nutritional marker to assess protein-calorie malnutrition and as prognostic indicator in critically ill patients. Transthyretin has shorter half-life (2–3 days) than that of albumin and belongs to negative acute phase proteins. This may complicate the use of transthyretin as a nutritional marker and the interpretation of results in the diagnosis of diseases. Although some studies have been carried out to determine the usefulness of transthyretin in selected disease conditions and disorders also in animals, it is a relatively rarely used parameter to evaluate health state and illness in veterinary medicine. The usefulness of transthyretin in the diagnosis of diseases and evaluation of nutritional status in humans and animals are reviewed in this article, including the laboratory assays available to measure its concentrations and the possible clinical application of the results, as well as its usefulness as a prognostic indicator in some disease conditions.",signatures:"Csilla Tóthová and Oskar Nagy",downloadPdfUrl:"/chapter/pdf-download/55194",previewPdfUrl:"/chapter/pdf-preview/55194",authors:[{id:"47101",title:"Prof.",name:"Oskar",surname:"Nagy",slug:"oskar-nagy",fullName:"Oskar Nagy"},{id:"62758",title:"Dr.",name:"Csilla",surname:"Tothova",slug:"csilla-tothova",fullName:"Csilla Tothova"}],corrections:null},{id:"56991",title:"The Intricate Relationship between Diabetes, Diet and the Gut Microbiota",doi:"10.5772/intechopen.70602",slug:"the-intricate-relationship-between-diabetes-diet-and-the-gut-microbiota",totalDownloads:1614,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The most recent World Health Organization report revealed that the number of adults suffering from diabetes has almost quadrupled since 1980 to 422 million, thus drawing attention to the urgent need to step up prevention and treatment of this disease. This chronic ailment is often associated with serious complications such as increased risk of heart disease, stroke and kidney failure. In 2012 alone, diabetes lead to 1.5 million deaths. This dramatic rise is mainly due to the increased prevalence of type 2 diabetes and factors driving it include overweight and obesity. Novel studies in this area have advanced our understanding regarding the complex relationship between diet, gut microbiota and diabetes. Despite no clear microbiota signature is associated with diabetes, patients harbour a reduction of butyrate-producing species (Faecalibacterium prausnitzii, Roseburia intestinalis) as well as an increase in opportunistic pathogens. Furthermore, the functions of the gut microbiome (i.e., vitamin metabolism, transport of sugars, carbohydrate metabolism, short chain fatty acid (SCFA) synthesis, etc.) are also different in patients with type 2 diabetes, a fact that may significantly alter the course of disease. Diet is one of the most decisive factors that have an impact on the gut microbiome. Nutritional interventions using prebiotics (i.e., inulin-type fructans), polyphenols and arabinoxylans have been employed for the treatment of diabetes. Besides the shifts produced by these dietary components in the microbiome composition, it is worth mentioning their impact on host physiology through modulation of gut peptide production and glucose metabolism. The information presented within this chapter summarizes the most recent advances in the study of the microbiome-diet-diabetes interplay and analyses how these novel findings can be used in order to establish new therapeutic approaches for those with diabetes.",signatures:"Gratiela G. Pircalabioru, Ariana Picu, Laura Petcu, Marcela Popa and\nMariana Carmen Chifiriuc",downloadPdfUrl:"/chapter/pdf-download/56991",previewPdfUrl:"/chapter/pdf-preview/56991",authors:[{id:"89452",title:"Dr.",name:"Mariana Carmen",surname:"Chifiriuc",slug:"mariana-carmen-chifiriuc",fullName:"Mariana Carmen Chifiriuc"},{id:"186347",title:"Dr.",name:"Marcela",surname:"Popa",slug:"marcela-popa",fullName:"Marcela Popa"},{id:"201071",title:"Dr.",name:"Gratiela",surname:"G. Pircalabioru",slug:"gratiela-g.-pircalabioru",fullName:"Gratiela G. Pircalabioru"},{id:"201558",title:"MSc.",name:"Ariana",surname:"Picu",slug:"ariana-picu",fullName:"Ariana Picu"},{id:"209974",title:"MSc.",name:"Laura",surname:"Petcu",slug:"laura-petcu",fullName:"Laura Petcu"}],corrections:null},{id:"56869",title:"Hypophosphatasia: A Systemic Skeletal Disorder Caused by Alkaline Phosphatase Deficiency",doi:"10.5772/intechopen.70597",slug:"hypophosphatasia-a-systemic-skeletal-disorder-caused-by-alkaline-phosphatase-deficiency",totalDownloads:995,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Hypophosphatasia (HPP) is an inherited systemic bone disease caused by the deficiency of tissue-nonspecific alkaline phosphatase (TNAP). HPP is classified into six forms and the symptoms of HPP vary depending on the form. The pathophysiology of HPP is basically due to a defect of bone mineralization. TNAP is encoded by the ALPL gene, and the TNAP protein expressed in bone, kidney, liver, and neuronal cells and is linked to the cell membrane via a glycosylphosphatidylinositol anchor. TNAP is an ectoenzyme hydrolyzing phosphate compound such as inorganic pyrophosphate. TNAP plays an important role in mineralization of hard tissues. Defect of mineralization process causes hypomineralization of hard tissues, which leads to rickets or osteomalacia and dental manifestations. In addition, hypomineralization of the ribs results in respiratory failure in the severe forms, which is the main cause of death. Inheritance of HPP is autosomal recessive, but autosomal dominant cases have been reported in the milder forms. To date, a total of 335 mutations in the ALPL gene have been reported, and mutation sites are scattered throughout the gene. Recent development of enzyme replacement therapy has opened up a new vista on the treatment of this previously untreatable disease.",signatures:"Hideo Orimo",downloadPdfUrl:"/chapter/pdf-download/56869",previewPdfUrl:"/chapter/pdf-preview/56869",authors:[{id:"200215",title:"Prof.",name:"Hideo",surname:"Orimo",slug:"hideo-orimo",fullName:"Hideo Orimo"}],corrections:null},{id:"57912",title:"Dynamic Properties of Skeletal Muscle Contraction in Rats with Diabetes",doi:"10.5772/intechopen.70600",slug:"dynamic-properties-of-skeletal-muscle-contraction-in-rats-with-diabetes",totalDownloads:978,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The study was conducted on 20 white nonlinear male rats, which were divided into 2 groups of 10 animals each. Rats in the first group were used as control. Rats in the second group were induced type I diabetes by intraperitoneal (i.p.) administration of streptozotocin (65 mg/kg). Diabetes in rats was confirmed by the presence of hyperglycemia. For the establishment of nociceptive pain sensation, mechanical nociceptive test and tail-flick test were conducted in rats. Further animals were anesthetized by i.p. administration of Nembutal (40 mg/kg). The study of dynamic properties of muscle contraction was performed under conditions of the tibia muscle activation by using the modulated stimulation of efferent n. tibialis. Streptozotocin (STZ) was injected in rats; as a result, the blood glucose level was increased by 4.4 times (p ≤ 0.001). Pain sensitivity in diabetic rats was suppressed, indicating the development of peripheral neuropathy. In rats with diabetes, biomechanical parameters of tibia muscle contraction such as the maximum force of contraction, the speed of maximum force of contraction, the retention time of maximum force of contraction and integrated power of muscle contraction (it is calculated on the total area of the received force curves) were violated. This prevents adequate implementation motor neuron pools muscular system, which will have significant consequences in accurate positional movements.",signatures:"Tetyana Volodymyrivna Beregova, Dmytro Nozdrenko, Sergii\nBerehovyi, Natali Nikitina, Tetyana Falalyeyeva and Liudmyla\nIvanivna Ostapchenko",downloadPdfUrl:"/chapter/pdf-download/57912",previewPdfUrl:"/chapter/pdf-preview/57912",authors:[{id:"205139",title:"Prof.",name:"Tetyana",surname:"Beregova",slug:"tetyana-beregova",fullName:"Tetyana Beregova"},{id:"205142",title:"Dr.",name:"Dmytro",surname:"Nozdrenko",slug:"dmytro-nozdrenko",fullName:"Dmytro Nozdrenko"},{id:"210850",title:"Dr.",name:"Nataly",surname:"Medvedeva",slug:"nataly-medvedeva",fullName:"Nataly Medvedeva"},{id:"210851",title:"Dr.",name:"Sergii",surname:"Berehovyi",slug:"sergii-berehovyi",fullName:"Sergii Berehovyi"},{id:"210852",title:"Ms.",name:"Natali",surname:"Nikitina",slug:"natali-nikitina",fullName:"Natali Nikitina"},{id:"210853",title:"Prof.",name:"Tetyana",surname:"Falalyeyeva",slug:"tetyana-falalyeyeva",fullName:"Tetyana Falalyeyeva"},{id:"210854",title:"Prof.",name:"Liudmyla",surname:"Ostapchenko",slug:"liudmyla-ostapchenko",fullName:"Liudmyla Ostapchenko"}],corrections:null},{id:"56932",title:"Immunopathology of Kidney Transplantation",doi:"10.5772/intechopen.70596",slug:"immunopathology-of-kidney-transplantation",totalDownloads:1365,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Renal transplantation is currently the best alternative for patients with end-stage renal disease. Immune responses activated against the allograft are a decisive factor in transplantation outcomes and patient survival. Although short-term graft and patient survival have improved significantly as a result of better donor matching systems, novel immunosuppressive agents and enhanced care, long-term outcomes remain unfavorable and reflect sub-clinical injury caused by chronic rejection. The immune system lies at the intersection of immunogenic tolerance and graft failure; thus, it is a major determinant of pathology in the context of renal transplantation. During the early stages of transplantation increased expression of cytokines has been observed in addition to increased expression of adhesion proteins and immune cells. This early inflammatory response does not necessarily end in graft rejection, although this will depend on the severity of the inflammation. Activation of Toll-like Receptors (TLRs), damaging molecular patterns (DAMPs), and other components of innate immunity is key to the formation of atherosclerotic plaques and the development of autoimmune diseases. Initially the donor antigens are presented to the T lymphocytes of the recipient. This activation induces their proliferation, differentiation and cytokine production. Successful kidney transplant recipients need to develop immunologic tolerance against donor antigens. In this chapter, we address some of the innate and adaptive immune mechanisms associated with kidney transplantation; emphasizing their role in allograft rejection.",signatures:"Zesergio Melo, Juan A. Ruiz-Pacheco, Claudia A. Mendoza-Cerpa\nand Raquel Echavarria",downloadPdfUrl:"/chapter/pdf-download/56932",previewPdfUrl:"/chapter/pdf-preview/56932",authors:[{id:"200199",title:"Dr.",name:"Zesergio",surname:"Melo",slug:"zesergio-melo",fullName:"Zesergio Melo"},{id:"201574",title:"Dr.",name:"Juan A.",surname:"Ruiz-Pacheco",slug:"juan-a.-ruiz-pacheco",fullName:"Juan A. Ruiz-Pacheco"},{id:"201575",title:"Dr.",name:"Raquel",surname:"Echavarria",slug:"raquel-echavarria",fullName:"Raquel Echavarria"},{id:"216623",title:"Dr.",name:"Claudia A.",surname:"Mendoza-Cerpa",slug:"claudia-a.-mendoza-cerpa",fullName:"Claudia A. Mendoza-Cerpa"}],corrections:null},{id:"56898",title:"The Way from Renal Calcifications and Urinary Crystals to Kidney Stones: An Important Aspect in the Pathogenesis of Calcium Nephrolithiasis",doi:"10.5772/intechopen.70598",slug:"the-way-from-renal-calcifications-and-urinary-crystals-to-kidney-stones-an-important-aspect-in-the-p",totalDownloads:986,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The formation of calcium (Ca) stones occurs in an initial phase by fixed growth on kidney calcifications consisting either of intratubular crystal accumulations protruding in renal calices (Randall’s plugs) or of interstitial hydroxyapatite deposits (Randall’s plaques) broken through the covering epithelial layers. Crystal aggregation (AGN) seems to be responsible for stone growth during crystalluria. This chapter reports on new aspects of the AGN of calcium oxalate being the most frequent stone compound and tries to explain why despite the widespread occurrence of kidney calcifications and crystalluria not everybody forms stones. Urinary crystals normally are protected from AGN by coats of urinary macromolecules (UMs) which by their identical electronegative charge create zones of electrostatic repulsion. At high urinary concentration or ionic strength respectively, these zones are compressed and can be bridged by self-aggregated UMs. Self-AGN occurs in concentrated urine by the adsorption of UMs on free surfaces like Randall’s plugs or plaques. High oxalate excretion and high urine concentration favoring intratubular crystal accumulation, breaking of epithelial layers on Randall’s plaques and self-AGN of UMs are most deleterious factors in Ca stone formation and have to be avoided by stone metaphylaxis.",signatures:"Johannes M. Baumann",downloadPdfUrl:"/chapter/pdf-download/56898",previewPdfUrl:"/chapter/pdf-preview/56898",authors:[{id:"205060",title:"Prof.",name:"Johannes",surname:"Baumann",slug:"johannes-baumann",fullName:"Johannes Baumann"}],corrections:null},{id:"59625",title:"An Overview on Prostate Pathophysiology: New Insights into Prostate Cancer Clinical Diagnosis",doi:"10.5772/intechopen.74269",slug:"an-overview-on-prostate-pathophysiology-new-insights-into-prostate-cancer-clinical-diagnosis",totalDownloads:1556,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:1,abstract:"The prostate is an accessory gland of the male reproductive tract, and its presence is universal in mammals. It is committed to the prostatic fluid production and storage, which is released with other semen components during ejaculation. Such fluid contributes to increasing motility and fertility of the spermatozoa, and the neutralization of the vagina, thus playing an important role in fertilization. Few pathological complications, often progressively aggravated with age, can affect this gland (i.e. benign and malignant proliferative changes; all to be described next in this chapter). Nowadays, the neoplastic expansion is the main motivator and contributor for studies on enlightening of growth regulation mechanisms and physiology of the prostate.",signatures:"Gustavo Ferreira Simoes, Paula Sakuramoto, Caroline Brito dos\nSantos, Nilva Karla Cervigne Furlan and Taize Machado Augusto",downloadPdfUrl:"/chapter/pdf-download/59625",previewPdfUrl:"/chapter/pdf-preview/59625",authors:[{id:"219765",title:"Dr.",name:"Taize",surname:"Augusto",slug:"taize-augusto",fullName:"Taize Augusto"},{id:"222944",title:"Dr.",name:"Gustavo",surname:"Simoes",slug:"gustavo-simoes",fullName:"Gustavo Simoes"},{id:"222945",title:"Dr.",name:"Nilva",surname:"Cervigne",slug:"nilva-cervigne",fullName:"Nilva Cervigne"},{id:"222946",title:"Ms.",name:"Paula",surname:"Sakuramoto",slug:"paula-sakuramoto",fullName:"Paula Sakuramoto"},{id:"222947",title:"Ms.",name:"Caroline",surname:"Santos",slug:"caroline-santos",fullName:"Caroline Santos"}],corrections:null},{id:"59825",title:"Polycystic Ovary Syndrome, Pathophysiology, and Reproductive Health Implications",doi:"10.5772/intechopen.70848",slug:"polycystic-ovary-syndrome-pathophysiology-and-reproductive-health-implications",totalDownloads:1426,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. The clinical picture characterized by both endocrine disorders (hyperandrogenism, menstrual cycle disorders, obesity) and metabolic alteration with implications for women’s health and reproductive and metabolic consequences. Leventhal described for the first time a syndrome characterized by polycystic ovaries associated with menstrual cycle disorders, hirsutism, and obesity. The pathophysiology and other metabolic disorders that make the PCOS more complex than originally described are the most common cause of infertility linked to chronic anovulation. In fact, this is a multifactorial disorder that involves the hypothalamus, pituitary, ovary, adrenal, and peripheral adipose tissues, which are simultaneously involved in the pathogenesis of the syndrome.",signatures:"Bassim Alsadi",downloadPdfUrl:"/chapter/pdf-download/59825",previewPdfUrl:"/chapter/pdf-preview/59825",authors:[{id:"204687",title:"Ph.D.",name:"Bassim",surname:"Alsadi",slug:"bassim-alsadi",fullName:"Bassim Alsadi"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"1840",title:"The Cardiovascular System",subtitle:"Physiology, Diagnostics and Clinical Implications",isOpenForSubmission:!1,hash:"a6a573b1908e6bcab874e3f8bda10705",slug:"the-cardiovascular-system-physiology-diagnostics-and-clinical-implications",bookSignature:"David C. 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\r\n\tOver these last decades, ionic liquids were found suitable in the world of industry. Due to their specific properties such as very low volatility, high thermal stability, and their ability to dissolve a wide variety of compounds, this family of solvents appears to meet the rigorous criteria of industrial applications. Among others, ionic liquids appear to be efficient for gas capture, biomass pretreatment, separation problems, electrochemistry; they are also used in electrolytes, as lubricants, as catalysts, or as antistatic agents.
\r\n\r\n\tThis book welcomes topics related to biomass pretreatment, separation processes, analytical chemistry, energy applications, and biomedicine applications using ionic liquids. A short chapter will be devoted to the physicochemical properties of ionic liquids as well as to the predictive models for the estimation of thermodynamic properties useful in the industry. This book is recommended for researchers to whom ionic liquids are an area of interest.
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In sheet hydroforming, formed tooling blocks are placed in the machine’s loading tray and pre-cut sheet metal blanks are placed over the blocks. Throw pads are then placed over the blanks to cushion sharp edges. The tray is then fed into the pressing chamber as a thick elastic blanket is unrolled over the tool and sheet metal. The pressure chamber is a thick-walled cylinder wound with high tensile strength metal wire that is engineered to handle the extremely high forming pressures. Once the part is loaded, immensely high fluid backfill pressure is applied to the membrane. The elastic blanket diaphragm expands and flows downward, over and around the metal blank. The sheet metal is then pressed to follow the contour of the die block, exerting an even, positive pressure at all contact points. As a result, the metal blank is literally wrapped to the exact shape of the die block. The press is then depressurized for unloading the tray. This process is ideal for prototyping and low volume production in aluminum, titanium, stainless steel, and other aerospace alloys such as matrix metal panels in low volumes [1, 2].
\nThe new fuel economy standards which mandate an average fuel economy of 54.5 miles per gallon for the 2025 model year will highly motivate auto manufacturers to step up development of improved vehicle designs and technologies to sharply improve the fleet mileage. Mass produced models will need to utilize more efficient engines and new lighter but safe car bodies. Automobile manufacturers have investigated alternatives to the steel traditionally used in car production. However, in most cases, the on-road properties of steel make it the best choice for automotive fabrication [3]. As a result, we are seeing a renewed interest in the use of high-strength steel and composites.
\nCarbon-fiber composite car structures are now in vogue. BMW produces two all carbon electric vehicle designs the i3 and the i8. General Motors’ Corvette Stingray has a carbon-fiber roof and hood. Other recent autos that feature carbon-fiber-reinforced polymer (CFRP) components include the Audi R8, the BMW M6, and the Dodge Viper. Most of these models, however, are high end, low-volume vehicles that are mainly assembled manually because composites use in low and medium-priced cars is still awaiting the development of cost effective mass-production processes and materials [4, 5].
\nThe goal of the NASA General Aviation Program is to reduce public travel times by half in 10 years and by two-thirds in 25 years. To accomplish this goal, NASA and its partners are pursuing development of the revolutionary technologies necessary not only to build the next generation of vehicles for business and personal air transportation but also to train the average person to operate them safely. Low cost composite panels are vital to the success of NASA’s program which supports electric aircraft and H.R. 1848, “The Small Airplane Revitalization Act” [6, 7, 8].
\nThe world has recently seen massive advancements in architecture. Numerous buildings in places such as Dubai have advanced the state of the art well beyond previous construction methods. Leading architects such as Frank Gehry, Zaha Hadid, and others are deep in a renaissance of building construction esthetics and methodologies.
\nStructures fabricated from numerous unique panels are especially well suited to production applications. Computer Aided Design (CAD) software is now used to convert complex 3D geometric forms into numerous 3D architectural SIP (Structural Insulated Panels) panels of a manageable size and shape. The panelized surface architecture process can be applied to buildings, sculptures, ships and aircraft [9].
\nThe Globe Company (Figure 1) now produces a pressurized air driven bladder technology that is used to form body panels for the Chevy Corvette. This process uses 300 psi of air with a 0.5 mm silicone sheet bladder to pressure bag form parts. They are currently supporting volumes of 34,000 vehicles a year [10, 11].
\nCross sections of processes: (A) globe manufacturing (left); (B) quickstep composites (middle); (C) hydrothermal hydroforming (right).
Quickstep is an Australian-listed company. The Quickstep process forms composite parts using 4 psi (low pressure) on a rigid tool suspended between two elastomeric membranes back filled with glycol fluid. Their large format out of autoclave forming and curing process works well for large parts. Aerospace parts such as wing skins can be molded using either prepreg materials or resin injection molding [12, 13].
\nIn this chapter, an “Out of Autoclave (OOA) HydroElastic Hydroforming” method is proposed to utilize pressurized water as a forming fluid behind an elastomeric membrane. The shell tool is water heated and backed by a high strength reusable fiber/epoxy composite [14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24]. In addition to the forming chamber shown, an outer sleeve chamber is used to contain extremely high pressures [25, 26]. Because of this high-pressure capability, the system can simultaneously form laminate stacks of both metal and composite material strata using the OOA hydroforming approach. This opens new potential possibilities for metal [27, 28, 29, 30, 31, 32] and fiber reinforced composite flat panel [33, 34, 35] as well as contoured part designs [36, 37].
\nOne of the most exciting materials under evaluation for primary and secondary aircraft components is GLARE laminate. Glass Laminate Aluminum Reinforced Epoxy (GLARE) is a sandwich material constructed from alternating layers of aluminum and S-2 Glass® fiber with bond film. The material, developed at Delft University of Technology in the Netherlands, has been recognized as one of the top aerospace materials for the future.
\nIt is believed that thermo-hydroforming has the potential to form GLARE multi-sheet material stacks. This would create a 3D conformal forming process that allows full design engineering of complex 3D shaped parts as needed. The parts are formed in a tool die that allows the part to be configured exactly as needed for the specified function. In addition, thermo-hydroforming forming, will enable subtle surface inflections to be made in parts for things such as flush access doors, flush rivets and flanges as well as embedded cast–forged, electrical or intelligent components.
\nThis project seeks to gain a foundational understanding of the proposed thermo-hydroforming machine’s performance by conducting FEA simulations [38, 39, 40]. This simulation studies a multiply coupon of carbon fiber prepreg being formed by a vulcanized silicone elastomeric bladder. The bladder is heated and pressed into the composite coupon by water heated to 285°F under 300 psi of pressure. The tool is pre heated to the temperature of 285°F as well. As a result, the composite coupon is heated from above and below. This process should be used comfortably to 425°F (218°C) and 10,000 psi/700 Bar.
\nWe understand from work by Globe manufacturing, Quickstep Composites and other prior art that both air and fluid heat behind a membrane can be used to react and cure prepreg materials. It is also known that pure water has one of the best thermal conductors. Water has a thermal conductivity that is 24 times greater than that of air and that circulating water increases this effectiveness even further by a factor of 10. Our objective is to study the viability of adopting these methodologies to hydroforming.
\nHydroforming has a well-documented history of safely forming sheet metal materials at pressures of up to 20,000 psi (137.89 Mpa) well beyond the requirements of composite materials. Because hydroforming machines can deliver and contain high fluid pressure, it is believed that the addition of a thermal cycle to heat & cool the forming chamber’s working fluid will enable a significant industrial advancement in sheet hydroforming machines. The new methodology will allow for a single machine to shape, catalyze and cure prepreg composite materials, thermal plastics and matrix materials in addition to its traditional use as a metal forming machine.
\nWith FEA simulations demonstrated, qualitative assessments can be made to facilitate the future validity for development, implementation and commercialization of thermo-hydroforming machinery.
\nFresh water has a very high level of thermal conductance. It is 100% better than glycerol and 350% better than machine oil. However, in order to be used at high temperature water must be pressurized to prevent boiling. In this design configuration pressure is applied as a part of the process. As a result, at 300 psi water can be used at temperatures of approximately 400°F (Figures 2 and 3).
\nThermal expansion of select materials.
H2O pressure vs. boiling temperature.
The first load step consists of a linear static analysis where only the pressure load is applied. This allows for the composites to be in contact with the tool. Following this, a transient coupled thermal displacement step is run to obtain the temperature distribution and heat flux through time. Total time used was 200 s.
\nThe geometry consists of an expandable silicon rubber bladder, which contains a convective medium inside. This convective medium is not modeled, however, the effects of convection on the general temperature distribution are important and therefore, simulated. Two different bladder thicknesses were evaluated: 6 mm and 12 mm. The bladder sits on top of a Torayca 300 carbon/epoxy prepreg laminate consisting of the following stacking order: (0, −45, 90, 45)2. The laminate sits on top of a concave aluminum tool (Figures 4 and 5).
\nGeneral dimensions of the model.
Assigned materials for each component.
\n
The rubber bladder at room temperature is pressurized with hot fluid (285°F). The bladder heats up by convection until it reaches thermal equilibrium with the hot fluid.
The Rubber bladder expands downward due to the exerted pressure of 300 psi and pushes the composite laminate onto the aluminum tool which is also heated to 285°F.
The composite laminate which has a cold OTF (Out of Freezer) temperature of 65°F is heated by the tool and rubber bladder by means of thermal conduction until thermal equilibrium is achieved.
The following mechanical and thermal properties (Tables 1, 2, 3) of the respective component’s material were assigned to the different parts to proceed with the FEA simulations.
\nMaterial | \nElastic modulus (Mpa) | \nPoisson ratio | \nDensity (Ton/mm3) | \n
---|---|---|---|
Composite Laminate | \n135,000 | \n0.3 | \n1.76E-09 | \n
Steel | \n210,000 | \n0.3 | \n7.89E-09 | \n
Silicon Rubber | \n50 | \n0.48 | \n1.70E-09 | \n
Mechanical properties of assigned materials.
Material | \nHeat conductivity specific heat | \n|
---|---|---|
Coefficient (mJ/mm K) | \n(mJ/Ton K) | \n|
Composite Laminate | \n10.46, 7.2, 9 | \n795,000,000 | \n
Steel | \n43 | \n466,000,000 | \n
Silicon Rubber | \n1.375 | \n1,180,000,000 | \n
Thermal properties of assigned materials.
Material | \nConvection coefficient (mW/mm2 K) | \nEfficiency | \n
---|---|---|
Free air | \n0.0015 | \n1X | \n
Free water | \n0.06 | \n40X | \n
Moving water | \n5.15 | \n3433X | \n
Convection coefficients for different liquids.
Shown in Figure 6, the bladder is fixed from the top, to allow the bottom to expand downward, pushing the composites towards the tool. The tool is also fixed so the compressive load is applied to the composites.
\nBoundary conditions applied to the model.
Shown in Figure 7, a uniform pressure of 300 psi was applied to the bottom inner surface, to simulate the bladder expansion which pushes the composite towards the tool. Initial temperatures assigned to the parts were shown in figure.
\nInitial temperatures for each part.
During this first load step, thermal conduction between the bladder and the composite laminate is ignored, this allows for the display of the thermal contour of the bladder as it heats up due to convection (Figures 8, 9, 10, 11).
\nNodal temperature results at t = 0 s (initial state).
Nodal temperature results at t = 8.38 s.
Nodal temperature results at t = 70 s.
Nodal temperature results at t = 120 s (bladder completely heated up).
Once the bladder is at operating temperature (285°F), the expansion due to the fluid’s pressure is simulated. This makes the bladder expand, which consequently pushes the composite plate towards the concave aluminum tool (Figure 12).
\nExpanded bladder due to applied pressure of 300 psi (the composite plate and tool are in contact).
The final load step in the simulation is to enable the thermal conduction between the bladder and the tool towards the cooler composite laminate (Figures 13, 14, 15, 16, 17, 18).
\nNodal temperature results at t = 120 s (respective to current load step).
Nodal temperature results at t = 130 s, t = 120 s (respective to current load step).
Nodal temperature results at t = 147 s (respective to current load step).
Nodal temperature results at t = 274 s (respective to current load step).
Nodal temperature results at t = 338 s (respective to current load step).
Nodal temperature results at t = 438 s (respective to current load step).
Additionally, one element per composite layer was probed to analyze its temperature through time. The selected elements were those in the symmetric center of the composite laminate. The same procedure was used for the bladder, to measure the time required for it to reach its working temperature (Figures 19, 20, 21, 22, 23).
\nNodes selected for plotting the temperature gradient throughout the composite material thickness.
Nodes selected for plotting the temperature gradient throughout the composite material thickness.
Composite temperature history.
Bladder temperature history.
Effect of the aluminum tool on the overall curing process.
It can be concluded that both air and water provide similar curing temperatures for the composite laminate, however, the warm-up time is considerably different for the two convective mediums as it can be observed in the above presented results. Air is considerably slower in warming up the silicon bladder up to operating temperature. Once the aluminum tool and the silicon bladder are at operating temperature, the bladder thickness nor the convective medium have much effect on the overall curing process time. It is only until the very end that the different convective mediums display different curing rates.
\nBased on results of the simulation provided, the use of a snap cure epoxy binder, and an additional 90 second cycle to cool the part; It seems highly probable that parts can be formed in a hydroforming machine in approximately 10 min. With the addition of residual heat in the bladder and some process optimization it may be possible to reduce the actual cycle time 30% further to 7 min. Physical experiments are needed for validation.
\nA large hydroforming tray bed may be able to form 4–6 parts in one cycle. A 10-min cycle running 4 parts produces a 2.5-min average part cycle time. A 250 days’ work year, running a 7-h shift would produce 42,000 parts per year. The envisioned ability to form and cure metal composite laminated parts in one single hydroforming process step has yet to be physically proven, but based on simulations it is highly promising. More in-depth study and physical models will be required to fully validate the process. However, based on the initial work completed, it seems viable to project, that a hydroforming machine can be used to form composite parts.
\nIt also seems viable that a hydroforming machine is well suited to accommodate the high pressures required by some snap-cure resins such as HexPly M77. This particular resin requires a pressure of 80 bar (1160 psi). Over a large wide surface area, 80 bar will generate significant force. However, hydroforming machine are designed for much greater loads and would easily accommodate the level of pressure. The ability to co-form metal alloys and composite materials seems to be viable and is believed to be a topic worthy of additional study.
\nVehicles produced for H.R. 4013 (IH)—Low Volume Motor Vehicle Manufacturers Act of 2014, 2025 CAFÉ Corporate Average Fuel Economy mpg target of 54.5 and the needs of General Aviation, advancement especially electric aircraft may attain benefits from this study.
\n\n
Typology Optimized Structural Sandwich Panels (SSP)
SSP Panels and skin panels with embedded electrical circuits, sensors, induction fields
SHM Structural Health Monitoring of panels
Heating from above and below accommodates use of panel cores with insulating properties such as porous media, foams gels and ceramics
3D structural battery or structural capacitor skin panels
Power and communications integral to panels
Induction field-based panel warping
Induction field based electromagnetic lock downs and energy pick up
Large area pressure sensitive/pressure monitoring panels or tiles
Embedded surface heating for de-icing
Damaged Part and Part Deflection Detection/SHM Structural Health Monitoring
Insertion of “Heavy Inserts” such as ceramics, castings, forgings or computers
Large 3D conformal structural storage tanks for liquid or air-gas fuel
Electric vehicles, electric aircraft, robotics
Integration of EAP (Electroactive Polymer) into skin panels
Electroactive Polymer (EAP) is a polymer that exhibits a change in size or shape when stimulated by an electric field. The field generates coulomb attractive forces on the electrodes that apply compressive forces on the dielectric causing the change in size or shape. There are three primary types of EAP: Ionic, Piezoelectric and Dielectric. EAP can be used to create a variety of devices including sensors, actuators, and energy harvesting devices. Inclusion of EAP into composites laminate sandwich panels may have potential for a few excellent features such as vibratory deicing or wing warping.
\nIndustrialization, urbanization and over exploitation of precious natural resources have resulted in much degradation of our environment. The dire need for promotion of intensive cultivation to satisfy primary human needs led to over dependence on chemical resources. This in turn, caused much degradation to our ecosystem mainly through environmental pollution. Among the natural resources, the worst affected are water resources. 97% of hydrosphere is covered by saltwater, leaving only mere 3% fresh water, of which hardly 1.5% is available for ready use [1]. The entire world is relying on this meager resource for daily consumption, irrigation, industrial purposes, power and other diverse uses. Injudicious human activities including disposal of sewage and wastes have caused great impact on water bodies all over the world. Wetlands act as sink for contaminants and thereby reduce the impact of point and non-point sources of pollution [2]. But drastic reduction in water inflow has been resulted due to fragmentation of water bodies and irreversible conversion to satisfy human needs.
Heavy metal pollution in water bodies is a serious environmental problem, threatening not only the aquatic ecosystems, but also human health. Over the years, the main sources of metal pollution have shifted from mining and manufacturing to rock weathering and waste discharge [3]. There are several reports on the deleterious effects of biomagnification of heavy metals within aquatic organisms and its impact on human nervous, reproductive and cardio vascular systems [4]. Disposal of plastic wastes, batteries, fertilizer materials, untreated industrial effluents etc. releases heavy metals including Cd into the aquatic environment which causes several causalities like osteoporosis, kidney failure, infertility and improper brain development. Globally, majority of surface water bodies are highly polluted with heavy metals like As, Co, Cr and Ni, with levels exceeding WHO and USEPA guideines and have evoked much concern among the government agencies and public [5].
As heavy metals are non-biodegradable, removal of these metals from the aquatic system is the only remedy available for decontamination [6]. The conventional methods usually employed to remove the metals from a polluted system like coagulation, flocculation, osmosis, stabilization etc. are highly expensive. In addition, they further aggravate deterioration with the release of chemicals being used and hence these methods are not at all environmentally safe [7, 8]. But, a new method of decontamination employing green plants is fast emerging, referred as phytoremediation, which is specifically suited for wetland restoration. The plants growing in the contaminated areas will absorb the elements from the sediment/soil/water by roots. The absorbed elements travel from root through cell sap and finally get precipitated in vacuole or cell membrane, thereby reduces the level of contaminants in sediment/soil/water [9]. Such aquatic plant species and adsorbents can be included in land management plans to reduce human risks. This method is relatively cheap and very successful over other methods [10].
The concept of extraction of metals by macrophytes was actually given by Chaney [11]. Efficiency of macrophytes to extract metals from contaminated site depends on the metal hyperaccumulation capacity and biomass production. The selection of particular plant species for phytoremediation depends on the following characteristics:
native to the particular ecosystem.
well flourishing nature and high biomass yield.
ability to uptake large amount of metals.
transportation of metals to aboveground plant portion.
mechanism to tolerate metal toxicity.
In addition, factors like pH, light intensity and nutrient availability influences the plant growth and thus, phytoremediation potential [12, 13, 14, 15, 16]. Agronomic practices for soil and crop management and improved genetic engineering technologies to enhance metal tolerance and translocation can affect the remediation mechanism. Exsituas well asinsitu methods of phytoremediation are there:
Depending upon the process by which plants/microbes are removing or reducing the toxic effect of contaminants from the soil and water, phytoremediation technology can be broadly classified as follows:
Phytoextraction or phytoaccumulation –This refers to the uptake and translocation of metal contaminants in the soil by plant roots with subsequent transport to the aerial plant organs. Certain plants called hyperaccumulators absorb unusually large amounts of metals in comparison to other plants and concentrate them in the aerial portions [11, 18, 19, 20].
Phytosequestration–The phytochemicals that are released into the rhizosphere may form complex association with the contaminants, sequestering them in the root zone and thus reducing their mobility This prevents further transport to soil, water and air. The complexation can also occur with the aid of transport proteins on root surface or through sequestration in the vacuoles of root cells [21].
Rhizofiltration - It is the adsorption or precipitation of contaminants onto plant roots or absorption into the roots that are in solution surrounding the root zone. The acclimatized plants against contamination are planted in the contaminated area and the roots extract the contaminants along with water. As the roots become saturated with contaminants, they are harvested and incinerated [22, 23, 24, 25].
Phytodegradation or phytotransformation– Here, organic pollutants are converted by internal or secreted enzymes into compounds with reduced toxicity. The metabolic processes, with the aid of enzymes within the plant or secreted externally, result in the degradation of pollutants and may be incorporated into the plant tissues or used as nutrients [20, 26, 27].
Rhizodegradation–Microbial activity in the rhizosphere results in the breakdown of contaminants, leading to their phytoremediation. Compared to phytodegradation it is a much slower process. Microflora (yeast, fungi, or bacteria) utilize the organic substrates for nutrition and energy [28, 29].
Phytostabilization–The particular plant species involved helps in the immobilization of contaminants through absorption and accumulation by roots, adsorption onto roots, or precipitation within the root zone. This results in reduction in mobility of contaminants and migration to ground water or air is blocked, which in turn hinders their bioavailability [30, 31].
Phytovolatalization –It is the uptake and transpiration of contaminant by a plant, with the release of that contaminant or its modified form to the atmosphere. In this process, the soluble contaminants are taken up along with water by the roots, transported to the leaves, and volatized into the atmosphere through the stomata. For
Among the different methods of phytoremediation, phytoextraction by hyperaccumulators is the most efficient one as it helps in removal of the phytoextracted biomass from contaminated sites. But phytoremediation cannot be used as a primary treatment method for highly contaminated areas with heavy metals like Cd, Zn, Cr and Pb, because of the prolonged time taken for the complete clean up. The dominant families that include hyperaccumulators are Asteraceae, Brassicaceae, Caryophyllaceae, Cyperaceae, Cunouniaceae, Fabaceae, Flacourtiaceae, Lamiaceae, Poaceae, Violaceae, and Euphobiaceae. Brassicaceae has the largest number of taxa
Aquatic macrophytes constitute a group of taxonomically diverse macroscopic plants whose life cycle takes place completely or periodically in the aquatic environment. They play a dominant role in maintaining the ecosystem biodiversity, represented by 33 orders and 88 families, numbering about 2614 species in 412 plant genera. The wide adaptation in their growing habits help them to classify as emergent, floating-leaved, free-floating, submerged and marginal plants [35, 36].
eg.
In the given Table 1, some common aquatic macrophytesand their specificity for particular elements are detailed.
Macrophyte group | Plant species | Heavy/toxic metal | References |
---|---|---|---|
Pb | [37] | ||
Pb, Cd | [38, 39, 40] | ||
Fe | [41] | ||
Al | [42, 43] | ||
Pb, Mn and Zn | [44] | ||
Pb | [45, 46] | ||
Pb, Cd | [40, 47] | ||
Cd | [48, 49] | ||
Pb, Cd | [50, 51] | ||
Al,Pb, Cd, Fe, S | [49, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61] | ||
Al, Fe | [52, 62] | ||
Fe | [53, 62] | ||
Cd | [63] | ||
Pb | [64] | ||
Pb, Cd | [65] | ||
Al, Fe, Si, Mn, Pb | [66, 67] | ||
Al, Fe, Si, Mn | [66] | ||
Al, Fe, Si, Mn | [66] | ||
Pb | [46] | ||
Pb | [46] | ||
Al, Pb, Cd, Fe | [68, 69, 70, 71, 72] | ||
Fe, Al | [68] | ||
Pb | [56, 73] | ||
Pb | [40, 74] |
Common aquatic macrophytes and their phytoremediation potential.
These macrophytes have the ability to concentrate metals both in the root and aerial parts, without causing any toxic symptoms on plant growth. In general, the submerged and floating macrophytes have the potential to accumulate more metals than emergent ones. Rhizofiltration offers much scope in the purification of heavily contaminated precious water resources, a big boon for eco restoration of aquatic systems.
The hyperaccumulation potential of macrophytesare determined primarily based on two indices
A high value for TF indicate the efficiency of the plant to translocate metals from the root to shoot and such plants (TF > 1) are referred as hyperaccumulators. They possess the phytoextraction ability to remove contaminants from the growth medium to the above ground portions and the biomass can be uprooted and removed. Aquaticmacrophytes, especially floating macrophytes, have the potential to concentrate metals more in the roots. Based on BCF and TF, the hyperaccumulation potential of
Accumulation of heavy metals inside the plant body results in certain physiological changes and synthesis of certain enzymes to tolerate the metal stress. Major changes that occur inside the plant cell to activate metal absorption include enhancement in the bioavailability of metal in the rhizosphere region leading to an increased uptake of metal towards the plasma membrane. Inside the cell wall, chelation of metal may occur by binding with various proteins like phytochelatin or, metallothionein or form a bond with the cell wall or get sequestered into the cell vacuole [76, 77].
Acidification of rhizosphere by the action of plasma membrane proton pumps and secretion of ligands capable of chelating the metal helps in desorption of metals from the soil matrix. Soluble metals can enter into the root symplast by crossing the plasma membrane of the root endodermal cells or they can enter the root apoplast through the space between cells. Excluder plants survive by enhancing specificity for the essential element or pumping the toxic metal back out of the plant. On reaching the xylem, the metal will get transported alongwith xylem sap towards the leaves and get deposited there. The cell tissue where the metal get deposited, vary with the hyperaccumulator species as shown by
At any point along the pathway, the metal could be converted to a less toxic form by chemical conversion or complexation. Various oxidation states of toxic elements have very different uptake, transport, and sequestration or toxicity characteristics in plants. Two major chelating peptides present in plants include metallothioneins and phytochelatins. Sequestration of metals in sites away from where the cellular processes are likely to be get disrupted will result in their deposition. The most prominent site is cell vacuole, for that metal or metal- ligand complex must cross the vacuolar membrane. Metal ions may also get bonded with negative charges on cell wall leading to their sequestration in the cell wall.
It is high time that the water bodies be conserved for ecological sustenance and well-being of the future generation. Aquatic plants can play a vital role in the purification of contaminated lakes, rivers and ponds, which make them fit for human consumption and irrigation purposes. The nature and extent of amelioration varies with particular plant species. They are specifically adapted to tolerate heavy/ toxic metal concentration in their ecosystems.
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\n\nWe have adopted the Protocol to increase the number of readers of our publications. All our Works are more widely accessible, with resulting benefits for scholars, researchers, students, libraries, universities and other academic institutions. Through this method of exposing metadata, IntechOpen enables citation indexes, scientific search engines, scholarly databases, and scientific literature collections to gather metadata from our repository and make our publications available to a broader academic audience.
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The first section of ninth chapter of this book introduces utilization of apatite ores for manufacturing of phosphorus. The second part deals with production of phosphoric acid via wet and thermal process and utilization of byproducts such as phosphogypsum, phosphorous slag and ferrophosphorus. 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These minerals and their synthetic analogs represent a major class of ionic compounds and the most common crystalline form of calcium phosphates, which are of interest of many industrial branches and scientific disciplines. Since, apatite (fluorapatite) is the most abundant phosphate mineral, apatite bearing phosphate rocks represents an important source of inorganic phosphorus. First chapter of this book introduces the basic concepts of nomenclature, composition, classification, crystal structure, mineralogy and properties of minerals from the supergroup of apatite. Furthermore, the minerals from the group of apatite and polysomatic apatites are described. 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