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1. Introduction
Aquaculture is one of the world’s fastest growing food production sectors with great potential for food supply, poverty alleviation, and enhanced trade and economic benefits, as targeted by sustainable development goals SDGs. The contribution of aquaculture to global fish supply increased from 3.9 percent in 1970 to over 41.3 percent in 2011 amounting to 63.7 million metric tonnes valued over USD 119 billion [1]. Its average growth rate of 8.8 percent has outpaced capture fisheries (1.2%) and terrestrial farmed meat production (2.8%) [1]. Aquaculture accounts for around 50 percent of seafood supply globally [2]. This quantity is expected to increase substantially as population increases (Figure 1). Aquaculture has gained much importance globally due to a decline in wild stock from natural water bodies; thus, aquaculture plays a key role in augmenting dwindling catch capture fisheries. It is well known that among other challenges facing the aquaculture sector, availability and quality of feeds affect its growth particularly in sub-Saharan (see for example [4, 5, 6, 7, 8, 9, 10]). Despite this challenge, aquaculture has been considered as one of the economic activities that contribute to poverty reduction, food security, and nutrition in the sub-Saharan Africa [4, 11, 12] and Asian countries [1, 13, 14, 15, 16, 17].
Figure 1.
Freshwater Aquaculture trend for African countries from 1990 to 2018 (data analyzed by this study see [3]).
In order to realize the contribution of aquaculture in the alleviation of poverty and improvement of food security, development agencies should broaden their focus beyond poor/subsistence producers to include small and medium enterprises adopting a value chain perspective [18]. Bangladesh, which is among developing countries, has proven that aquaculture intervention in resource poor and marginalized group marked an increase in income savings and frequency of fish consumption [19]. Although small-scale fish farmers play a big role in poverty reduction and food security, the intensification from extensive to semi-intensive is essential [20]. However, for the intensification to take place, there should be an increase in investment in technological innovation and transfer through (i) Nutrition, feeds and feeding management, and (ii) low-impact production systems. This paper discusses the valorization of animal waste/by products and plants/crops-by-products to produce fish at low cost in order to increase nutrition and reduce food insecurity.
2. Aquaculture production in Africa
Africa’s fisheries output is dominated by capture fisheries, but the contribution of aquaculture to the total amount of fish produced in the region has grown at a steady pace over the past decade (Figure 1). In these countries, fish is produced from capture fisheries and aquaculture. However, fish catches from wild sources have been declining, due to multiple anthropogenic pressures including climate change, overfishing, habitat destruction, invasion of non-native species, illegal, and unregulated fishing, and poor governance [21]. For example, consumption in the Eastern Africa region was projected to increase from 4.80 kg in 2013 to 5.49 kg by 2022 [22]. This implies that in order to meet the gap between fish production and the increasing demand for food fish, aquaculture production must double by 2050 to satisfy the Africa’s fast-growing human population [23]. An appropriate way of keeping this sector growing constantly is the development of new researches aimed at determining the benefits of using different and cheap resources of feeds and determining how these strategies influence economic and productive parameters.
In the aquaculture sector, Africa produced about 1400 tonnes of fish from freshwater aquaculture in 2018, but most of this came from Egypt, which contributed more than 70 percent of the total production (Figure 1, Data obtained in [3]). Major aquaculture producers in 2018 with more than 10,000 tonnes include Egypt, Nigeria, Ghana, Uganda, Zambia, Kenya, Tanzania, and Zimbabwe. Production has increased three times for the past ten tears from 563,000 in 2008 to 1,440,000 in 2018 (Figure 1, [3]). In general, African aquaculture production is overwhelmingly dominated by finfishes (99.3%), with only a small fraction of production from marine shrimps and mollusks [23]. Among the freshwater cultured finfishes, tilapia farming is the main product, which is also the most popular fish from a consumer perspective. Aquaculture production in Africa is also increasing as presented in Table 1.
Country
Total production
Percent
Egypt
930,344
70.476
Nigeria
160,114
12.129
Ghana
70,628
5.350
Uganda
70,095
5.310
Zambia
17,500
1.326
Kenya
12,160
0.921
Tanzania
11,000
0.833
Zimbabwe
10,500
0.795
Malawi
5036
0.381
Rwanda
4526
0.343
Mali
3524
0.267
Congo
3185
0.241
Cã’te d’Ivoire
3000
0.227
Benin
2802
0.212
Lesotho
2500
0.189
Madagascar
2372
0.180
Algeria
2045
0.155
Angola
1752
0.133
South Africa
1503
0.114
Burundi
1455
0.110
Others
4045
0.306
Total
1,320,086.62
100
Table 1.
Freshwater aquaculture production (tones) in Africa by country in 2018. (data analyzed by this study see [3]).
3. Aquaculture production systems
In Africa, aquaculture systems are made up of extensive and semi-intensive systems. Small-scale earthen ponds (extensive systems) are characterized by low inputs and low yields. However, semi-intensive systems are characterized by human intervention where by fertilization is done to improve feed availability, hence, improved fish yield. In East Africa, semi intensive mainly used to produce Oreochromis niloticus and Clarias gariepinus in either monoculture or polyculture [24]. They consist mostly of earthen ponds, liner ponds and concrete ponds.
Other systems include cage particularly in areas with large water bodies including East Africa great lakes. Cage culture involves holding organisms under captivity within an enclosed space while maintaining free exchange of water. Cages use the existing water bodies, therefore, require comparatively low capital outlay and use simple technology, they can be used not only as a method for producing cheaply and high-quality protein but also for cleaning up eutrophicated waters through the culture and harvesting of caged planktivorous species. Although fish farming in cages in the existing water body is considered inexpensive relative to pond construction and its associated infrastructures [25], the feasibility and profitability of fish cage culture is influenced by the cost of input invested and revenue collected from output.
Although not common, re-circulating aquaculture system (RAS) has been used in some countries particularly South Africa. RAS refers to a fish farming technology that reuse wastewater from tanks/rearing premises [26]. Water reuse in RAS is supported by both inline and end pipe treatment using a series of mechanical filter for solid waste removal, bio-filter for dissolved nitrogenous waste removal and sludge pond to settle suspended solid [27]. RAS technology is termed as sustainable advanced production system that provides constant and independent production conditions and reduces water consumption compared with semi-intensive pond aquaculture, RAS technology provides high fish productivity with better effluent control of environmental conservation [28, 29]. Some of the sub Saharan countries have benefited from high temperature to which RAS performs efficiently [30]. The adoption of the system is low due to high cost of initial capital investment in tanks and high cost of electricity required in running the system and feeds. This has therefore called for sustainable aquaculture by integration of fish with livestock. Such integration involves the recycling of livestock wastes and processing by-products as manure and/or direct food for fish. Today, aquaculture in developing countries is mostly a small-scale activity and is usually not practiced as a stand-alone economic activity, but rather as subsistence farming integrated with agricultural activities such as horticulture and rearing of livestock.
4. Organic manure and fish growth
The production volume and market share of aquaculture products are advancing extremely rapidly. However, feed is usually recognized as the single largest cost to producers, hence, the best way of reducing the cost of fish production is using organic manure and supplementary feed when available. Animal manure is widely used in developing countries in fish production in earthen ponds. The quality of manure as a fertilizer varies depending on the source of animal and the quality of feed fed to the animal [31, 32]. Research showed that pig, chicken and duck manures increase fish production more than cow and sheep manure. For example, in Asia, fish farming is probably the only branch of animal husbandry in which the use of manures is a traditional management tool. In Sub-Saharan Africa, ponds are fertilized using organic manures such as cow dung, sheep, poultry or rabbit manure [33]. The use of animal manure to fertilize ponds has been widely practiced in many countries in order to increase plankton so that there is more natural food for fish to eat, hence, high fish production. Manuring is therefore considered a cheap and preferred source of nutrient to increase fish production.
Pond fertilization with animal manure stimulates production of bacteria, phytoplankton, zooplankton, and benthic organisms [34]. The use of animal waste (livestock) has been studied under integration systems in Africa [35, 36, 37] and extensively in Asian countries [38, 39]. Benefits of integrated Agro-aquaculture systems have been reported in resource poor areas particularly in developing countries [38, 40, 41]. Studies conducted in sub-Saharan countries on the integrated aquaculture and agricultural systems are presented in Table 2.
Studies on the integrated agro-aquaculture in sub-Saharan countries.
Several studies showed that organic supplements contributed to fish yields by supplying P, N and C for algal growth and by stimulating detritus production and heterotrophic utilization. It is well known that high fish yields can be achieved through abundance of plankton in the cultural system [46]. Africa has vast resources of livestock and poultry, which play a vital role in pond fertilization. Livestock wastes including animal manure and poultry by-products are valuable resources in fish farming [47]. Livestock manure contains protein content of about 15 percent, energy (1250) kilocalories per kilogram, manure, and soluble vitamins [48].
5. Fish feed availability and the concept of valorization
One of the solutions of fish feed availability is to entice animal feeds producing industries to consider also the production of fish feed [49]. However, the big issue here will be affordability; of these industrial feed products; most of our farmers belong to subsistence income bracket, hence, they might not afford these feed products. The use of floating pellets needs higher investment [50], which in most cases is lacking among smallholders; and unless the government intervenes in addressing the problems through either credit facilities or the provision of subsidies, the situation is not likely to get any better. It has been established that profitability in aquaculture is influenced by the cost of feed [51]. In Sub-Saharan countries, justification for industrial scale production of fish feed is not a priority despite the availability of raw materials [4]. Therefore, in order to feed fish, farm-made feeds can be made using locally available ingredients including animal by-products and plant residues.
In Tanzania, more than 80 percent of fish farmers relied on locally available feed ingredients as a major feed supplement for their cultured fish [43]. These local feed ingredients are categorized into four groups, (i) animal by-products, (ii) agricultural by-products, (iii) plant leaves and weed, and (iv) industrial by-products. It has been reported that the early growth phase of tilapia in 1991–2000 was significantly contributed by the use of alternative sources of protein including fishery by-products, terrestrial animal by-products, and a wide range of plant by-products [52]. In this chapter, discussion is cantered on the valorization of two broad categories of ingredients, plant and animal based ingredients.
5.1 Plant based ingredients and by-products
In addition to fertilization, feeding in ponds is done using supplementary feeds formulated on farm or purchased from cottage fish feed production industries. In some cases, cereal bran such as grains as energy source (Figure 2) and soybeans as source of protein (Figure 3) are used in aquafeeds to increase pond productivity. The production from this system ranges from 1000 to 2500 kg/ha/year [33]. Most farmers prefer this system since it is less expensive in terms of feed inputs. Ten edible plant leaves were evaluated (see in [54]) as potential feed ingredients for aquatic animal, the results suggested that some of the plant leaves used contributed on growth performance, immune system, and disease resistance for the fish. Other important plant leaves which have been subjected to experiments to see whether they can be used as ingredients for fish feed formulation includes cassava leaves [55] and Moringa leaf [56]. In another study results showed that the integration of vegetables (Brassica oleracea) as pond inputs increased fish production and net yield than those reared under non-integrated systems [57]. In general, the amount of grain and soybean required in the four East African countries is given in Figures 2 and 3. Another experiment (see [58]), showed that when wheat bran, rice bran, and groundnut bran were used as agro-industrial by-products to examine their economic effectiveness in fish production, there were variability in growth rate and economic benefits, suggesting that variability of agro-by products reflects the growth rate of fish.
Figure 2.
Amount of grains required for fish feed compounding in East Africa. Source [53].
Figure 3.
Amount of soybean required for fish feed coumpound in four countries of East Africa. Source [53].
5.2 Animal based ingredients and by-products
According to the circular economy approach which focuses on the “reduce, reuse and recycle” of resources, waste from animal and food can be valorized leading to the production of proteins and other valuable compounds [59, 60]. For example, chicken, pig and cattle manures are substrates for production of housefly (Musca domestica) maggots which are in turn used as fish feed, or as supplement to fish meal in fish feed formulation [61]. Maggots are readily available and are accredited for having high nutritional value with an amino acid profile with biological value exceeding that of soybean and groundnut. Maggots can be harvested, processed into a meal that can be used to substitute or replace fish meal [61, 62]. Maggot grown on a mixture of cattle blood and wheat bran contained 92.7% dry matter, 47.6% crude protein, 25.3% fat, 7.5% crude fiber, 6.25% ash, and an amino acid profile comparable to fish meal [59] suggesting that animal wastes utilization can be used to produce insects which can be utilized as fish feed hence, reduce feed cost significantly, thus leading to a viable and sustainable aquaculture industry. The replacement of 25 percent fishmeal in catfish feed, culture with maggot gave high growth performance and profitability than fishmeal based diet [63, 64]. Several researches [65, 66] have been reporting on the use of red worms, black soldier fly, common housefly, and yellow mealworm as a source of protein to replace fishmeal. It is envisaged that the valorization of animal and animal by-products such as animal blood, offal of poultry, residues of traditional brewery waste, animal manure and fish wastes may contribute significantly on fish production hence, food nutrition and security.
6. Conclusion
It is clear that fish consumption in Sub-Saharan Africa is increasing. In order to maintain the present amount of fish consumption, considerable additional quantities of fish are required through aquaculture. In turn, aquaculture requires feed as a major input for increasing production. Since commercial fish feed production in most of the sub-Saharan countries is limited, considerable investments are required in local and low costs feed manufacturing. Raw materials of plant and animal origin are sufficiently available in the region albeit the possible competition from livestock and human consumption. Therefore, valorisation of animal and agro-products in the Sub-Saharan countries is imperative/inevitable for increasing fish production at low cost.
6.1 Recommendations
In order to increase food nutrition from aquaculture production through valorization of agro-by-products in the sub-Saharan countries, the following are recommended:
Strengthen the use of Public Private partnering by putting more emphasis in services related to the collection of feed ingredients and preservation
Public Private partnering must be embedded into an economic vision for aquaculture development
Recognize small scale farmers as commercial ones and encourage small-scale farmers to work together by forming associations (work groups)
Provide credit facilities for the private sector particularly for the small-scale holders
Put emphasis on public private research partnerships and knowledge sharing on valorisation
Provide capacity building and general education for small holders in order to improve their technological, managerial and commercial skills in handling agro by-products
6.2 The way forward
With the ever-increasing human populations in sub-Saharan countries, the demand for food would increase and natural resources will become even scarcer. This situation will be more worsen with severe climate changes. These trends necessitate for a critical assessment of the situation to enable devise informed solutions in addressing issues pertaining to agro by-product processing and valorization.
\n',keywords:"animal waste, fish farming, crop residues, farming systems, valorization",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/74479.pdf",chapterXML:"https://mts.intechopen.com/source/xml/74479.xml",downloadPdfUrl:"/chapter/pdf-download/74479",previewPdfUrl:"/chapter/pdf-preview/74479",totalDownloads:257,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:42,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"May 20th 2020",dateReviewed:"November 18th 2020",datePrePublished:null,datePublished:"July 14th 2021",dateFinished:"December 17th 2020",readingETA:"0",abstract:"Animal and crop production throughout the world generate high amounts of wastes or by-products annually that may possess added value compounds with high functionality. These wastes and by-products may cause negative environmental impacts and significant expenses if not well managed and or controlled. Much of these wastes and by-products is valuable and cheaper source of potentially functional compounds such as proteins, lipids, starch, micronutrients, bioactive compounds, and dietary fibbers. In aquaculture, feed is expensive, and the existing body of literature has shown that animal manure and its extracts can be successfully incorporated into fishpond to increase fish production at a low cost. In addition, crop residues such as rice bran, maize bran, and seed cakes are commonly used as pond inputs in small-scale aquaculture. Animal waste and crop residues are added in a fishpond that filter-feeding fish can use directly as feed, and these may form a major proportion of the detritus in the pond. These resources also stimulate the growth of phytoplankton that are rich in protein and are the basis of the food web that can support the growth of a range of herbivorous and omnivorous fish. Therefore, technically, wastes are used as direct feed, a source of minerals for autotrophic production and a source of organic matter for heterotrophic production. In this context, animal manure and crop residues have been used to provide great opportunities to improve food security. The purpose of this review is to project the potential of animal waste and agro-by-products as a sustainable alternative as aquaculture inputs to reduce poverty, malnutrition, and hunger in developing countries.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/74479",risUrl:"/chapter/ris/74479",book:{id:"10237",slug:"innovation-in-the-food-sector-through-the-valorization-of-food-and-agro-food-by-products"},signatures:"Renalda N. Munubi and Hieromin A. Lamtane",authors:[{id:"321709",title:"Dr.",name:"Renalda N.",middleName:null,surname:"Munubi",fullName:"Renalda N. Munubi",slug:"renalda-n.-munubi",email:"rmunubi@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"321966",title:"Dr.",name:"Hieromin A.",middleName:null,surname:"Lamtane",fullName:"Hieromin A. Lamtane",slug:"hieromin-a.-lamtane",email:"hlamtan@sua.ac.tz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Sokoine University of Agriculture",institutionURL:null,country:{name:"Tanzania"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Aquaculture production in Africa",level:"1"},{id:"sec_3",title:"3. Aquaculture production systems",level:"1"},{id:"sec_4",title:"4. Organic manure and fish growth",level:"1"},{id:"sec_5",title:"5. Fish feed availability and the concept of valorization",level:"1"},{id:"sec_5_2",title:"5.1 Plant based ingredients and by-products",level:"2"},{id:"sec_6_2",title:"5.2 Animal based ingredients and by-products",level:"2"},{id:"sec_8",title:"6. Conclusion",level:"1"},{id:"sec_8_2",title:"6.1 Recommendations",level:"2"},{id:"sec_9_2",title:"6.2 The way forward",level:"2"}],chapterReferences:[{id:"B1",body:'Moffitt CM, Cajas-Cano L. Blue Growth: The 2014 FAO State of the World Fisheries and Aquaculture. Fisheries. 2014;39(11):552-3'},{id:"B2",body:'Little DC, Newton RW, Beveridge MC. Aquaculture: a rapidly growing and significant source of sustainable food? Status, transitions and potential. Proceedings of the Nutrition Society. 2016 Aug;75(3):274-86'},{id:"B3",body:'Fisheries and aquaculture software. FishStatJ - software for fishery and Aquaculture statistical time series. In: FAO Fisheries Division [online]. Rome. Updated 14 September 2020. 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Department of Animal, Aquaculture and Range Sciences, Sokoine University of Agriculture, Morogoro, Tanzania
'},{corresp:null,contributorFullName:"Hieromin A. Lamtane",address:null,affiliation:'
Department of Animal, Aquaculture and Range Sciences, Sokoine University of Agriculture, Morogoro, Tanzania
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\n
1. Introduction
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The airfoil is the geometrically shaped structure for mechanical force generation from the relative movement between the airfoil and surrounding airflow of the airfoil structures [1]. For wind turbines, the airfoil shape of the blades influences the turbine power production. The lifting efficiency of the blades determines the effectiveness of rotor rotation to cause productive energy conversion from wind kinetics to rotor rotation, which leads to higher electricity generation from the drive unit.
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From the late eighteenth century, the curving surface geometry was discovered to be advantageous for lifting efficiency in windmill by Smeaton [2]. In the 1880s, Lilienthal discovered the specific shape from the bird’s wings, which inspired the airplane invention by Wright brothers [3]. The research of Prandtl and Tietjens revealed the benefit of the thick airfoil through their mathematical skills and wind tunnel tests in 1917 [4]. The US National Advisory Committee for Aeronautics (NACA)-generated airfoil groups, “NACA airfoil families” in the 1930s, and the series have been widely used even in these days [5]. In contradiction to the mathematical methods to calculate the pressure distribution of airfoil, Jacobs proposed the airfoil design which causes the desired pressure distribution. The laminar flow of airfoil was expanded to cause higher L/D ratio and smaller drag [6]. Later, different types of airfoils for various airplane design and off-design requirements were continuously designed.
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The first wind turbine blades were also designed by the airfoils from aeronautic applications. However, in the 1980s, the airfoils specially dedicated for wind turbines were begun to be made due to the defects of aeronautic airfoils applied in a wind turbine. The sensitivity roughness effect on the leading edge arose to be the required element for wind turbine airfoil. The airfoil series for stall-regulated, variable-pitch control wind turbine was developed by NREL in 1984, incorporated with SERI and Airfoils [7]. The wind turbine-dedicated airfoils with the thickness from 15 to 40% of the chord were also made by the team of the Delft University of Technology with the design objective of low sensitivity to roughness, Gurney flaps, and trailing-edge wedge consideration [8]. The airfoils from Risø were designed to have high aerodynamic efficiency and slender blade shape [9]. The airfoil design using numerical optimization for tip region of the blades was researched by Grasso [10]. As mentioned in these studies, the higher aerodynamic efficiency, insensitivity to roughness effect, structural stability and smooth post-stall exhibition, etc., are required for wind turbine airfoil design. To accomplish these objectives, boundary layer consideration of the wind turbine airfoil can be advantageous as it was proven from the laminar airfoil by Jacobs [6].
\n
The boundary layer of the airfoil is exerted by additional pressure generated by the curvature shape of airfoil compared to the constant pressure on boundary layer made of the plate with zero incidences. The pressure distribution on the edge of the boundary layer is same with the pressure distribution on the wall in the plate. However, due to streamline curvature of airfoil surface, the pressure gradients and compensation for the centrifugal force of the streamline flow are generated inside the boundary layer. Furthermore, the transition point of the boundary layer on the airfoil is determined by the outer flow and its pressure difference generated by the curvature shape of the surface [11].
\n
To generate the airfoil shape which has the advantage for pressure distribution in the boundary layer and transition points, genetic algorithm (GA) optimization was used in this study. As all airfoils are designed for higher aerodynamic performance, GA objective functions therefore had two objectives—higher transition points of the larger laminar boundary layer and higher gliding ratio (GR). The airfoil S809 of NREL airfoil series for the wind turbine was chosen as a reference. The shape of insensitiveness to the roughness effect of the airfoil S809 could be maintained in the optimized airfoil. The final evaluations of turbine performance were done with the sample of stall-regulated wind turbine of NREL phase VI, which consists of the same airfoil-type composition [12].
\n
The B-spline parameterization was used for the airfoil description, and the y points of the spline were considered to be the variables. The values of boundary layer parameters and GR of the airfoil were calculated by the flow solver XFOIL. The power performances of turbine unit with blades of the optimized airfoil were calculated by using blade element method (BEM) of the software QBlade. The CFD simulations from OpenFOAM® were performed to visualize the improved aerodynamic aspects.
\n
Section 2 explains the GA airfoil optimization method, Section 3 presents the aerodynamic and boundary layer results of the optimized airfoils with improved power production of turbine unit, Section 4 visualizes the airflow of the optimized airfoil with the reference, and Section 5 concludes this chapter.
\n
\n
\n
2. Genetic Algorithm optimization for airfoil
\n
The GA algorithm is based on the principle of the survival of the fittest and natural selection, observed by Darwin [13]. As the various bird breaks were developed for different foods that they can survive with, the airfoil was set to be shaped to survive at the condition of the highest GR and transition point. To put the airfoil in mathematical form, the B-spline was used, and its variables were set as the y point of control points in MATLAB® (\nFigure 1\n).
\n
Figure 1.
Airfoil B-spline parameterization with upper and lower bounds.
\n
The smoothness and number of variables were set according to the previous research for effective GA operation within a given computation time [14]. The airfoil is described with the B-spline. The corresponding equations and the example of description figure are the following. The x, y points are for the B-spline control points to compose P matrix in coefs for determining the smoothness of B-spline with k. When the constant a is designated, the knots are defined. The x points of B-spline are defined with MATLAB function linspace which divides the x-axis space according to the defined airfoil chord:
To achieve higher aerodynamic efficiency and larger laminar boundary layer region at the same time, the multi-objective function was formulated to evaluate both parameters of the airfoil. The objective function code was written as
Then, TXtr is the transition point of the top of airfoil, and BXtr is the transition point of the bottom part of airfoil surface. The GR values, TXtr and BXtr values, were given from the results of XFOIL calculation [15]. The given Re number was 106, and the angle of attack was 7°. The algorithm flow diagram is shown in \nFigure 2\n.
\n
Figure 2.
Genetic algorithm flow diagram.
\n
\n
\n
3. The optimized airfoil
\n
The airfoil shape with higher GR and transition points were given after the convergence of default set of population and running operation in GA. The thickness was almost the same as the reference, which was desirable thickness for the stall-regulated wind turbine, but the curvature shape was slightly changed (\nFigure 3\n and \nTable 1\n).
\n
Figure 3.
The optimized airfoil S809gx and the reference S809.
\n
\n
\n
\n
\n\n
\n
\n
S809
\n
S809gx
\n
\n\n\n
\n
Thickness (%)
\n
20.99
\n
20.3
\n
\n
\n
Max. thick. pos. (%)
\n
38.3
\n
38.7
\n
\n
\n
Max. camber (%)
\n
0.99
\n
0.87
\n
\n
\n
Max. camber pos. (%)
\n
83.3
\n
43.6
\n
\n\n
Table 1.
The optimized airfoil S809gx and the reference S809.
\n
However, this slight curvature shape change generated different GR and boundary layer transitions (\nFigures 4\n–\n8\n). As the gliding ratio was set to be higher at the angle of attack 7°, there was some region (off-design) where GR values of the optimized airfoil are lower than the reference. But the angle of attack range of increasing GR ratio was larger at the optimized airfoil (design point). This means that the optimized one has the smaller range of separation or stall occurrence, which is desirable for the stall-regulated wind turbine [7] (\nFigure 4\n).
\n
Figure 4.
Gliding ratio (Cl/Cd) distribution of the airfoil at the root, middle, and tip parts of the blades.
\n
Although the maximum GR values of the reference and optimized airfoils were similar, the advantage of the optimized is represented by the drag distribution in \nFigure 5\n. Significantly, reduced drag coefficients are found in \nFigure 5\n, which advocate the lower drag of the optimized curvature shape, especially at the stall regime. The reduced drags can be explained with the enlarged laminar boundary layer region of the optimized (\nFigures 6\n–\n8\n).
\n
Figure 5.
Drag coefficient distribution of airfoils.
\n
Figure 6.
Transition point (Xtr) of the airfoils in fully attached flow regime.
\n
Figure 7.
Transition point (Xtr) of the airfoils in transition-separation flow regime.
\n
Figure 8.
Transition point (Xtr) of the airfoils in dynamic stall flow regime.
\n
Figure 9.
Skin-friction coefficient (Cf) of the top and bottom surfaces of the airfoils.
\n
Figure 10.
The blade designs with airfoil S809 (left) and S809gx (right).
\n
Figure 11.
Annual energy production [kWh] of NREL phase VI turbine with the airfoil S809 and S809gx.
\n
Figure 12.
Generated mesh of the reference airfoil S809.
\n
Figure 13.
Velocity visualization with LIC, the airfoil S809 (top), and S809gx (bottom) at T = 650.
\n
Figure 14.
Pressure visualization, the airfoil S809 (top), and S809gx (bottom) at T = 650.
\n
The transition point distributions of the reference and optimized airfoils are compared in all angle of attack regime. The top and bottom mean the upper and lower sides of the airfoil. Including the angle of attack 7°, where the optimization was calculated, the transition points of the optimized S809gx showed the higher values than the reference S809, which means a larger laminar boundary layer. This tendency was found in all flow regime—fully attached, separation-transition, and dynamic stall regime. The boundary layer region difference can be also found by the skin-friction coefficient (Cf) (\nFigure 9\n). In the separation-transition flow regime where the tip-speed ratio (TSR) = 5 and the incoming velocity is 8.3 m/s, transition point comparison of two airfoils at the top and bottom parts is presented in \nTable 2\n. The Cf value at the leading edge of the top of the airfoil showed much higher value than the reference one. The Cf value hill range was also higher at the reference than the optimized one which indicates that the optimized one has the smaller shear wall stress on the top.
\n
\n
\n
\n
\n\n
\n
\n
S809gx
\n
S809
\n
\n\n\n
\n
Xtr_t
\n
0.4589
\n
0.1776
\n
\n
\n
Xtr_b
\n
0.6864
\n
0.5298
\n
\n\n
Table 2.
The optimized airfoil S809gx and the reference S809.
\n
Although the values were relatively smaller than the top, the bottom part Cf distribution shows the increasing and decreasing tendency change at the transition point. The optimized airfoil shows the changing point to be located to the right side than the reference. If the separation occurs at the point where shear stress gets zero, the optimized airfoil could have the smaller adverse pressure gradient region than the reference one at the bottom side.
\n
The improved aerodynamic efficiency of the optimized airfoil through laminar boundary layer enlargement affected the power increment of rotor turbine with the optimized airfoil. The wind turbine simulation of NREL phase VI blades with the airfoil S809 and S809gx is done with the blade incorporation. The settings for power performance comparison of two turbines are represented in \nTable 3\n (\nFigure 10\n). The wind turbine with optimized airfoil shows higher annual yield and power production at a given velocity condition (Figure 11). The increased power production means the effective rotor rotation of the wind turbine with the optimized airfoil, which was affected by lifting efficiency of the blades from the aerodynamically upgraded airfoil composition. The 3D rotation effect to reduce the root vortex could be another reason of increased rotor efficiency of the rotor as explained in Ref. [16].
\n
\n
\n
\n
\n\n
\n
\n
NREL phase VI with airfoil S809
\n
NREL phase VI with airfoil S809gx
\n
\n\n\n
\n
Power regulation
\n
Stall
\n
Stall
\n
\n
\n
Transmission
\n
Single
\n
Single
\n
\n
\n
V cutin/cutout [m/s]
\n
6/25
\n
6/25
\n
\n
\n
Rotational speed [rpm]
\n
71.63
\n
71.63
\n
\n
\n
Outer radius [mm]
\n
5532
\n
5532
\n
\n
\n
Variable losses
\n
0.22
\n
0.22
\n
\n
\n
Fixed pitch/fixed loss
\n
0
\n
0
\n
\n
\n
Weibull setting
\n
k 2(±3) A 9(±3)
\n
k 2(±3) A 9(±3)
\n
\n
\n
Annual yield [W]
\n
49,461,730
\n
59,404,491
\n
\n\n
Table 3.
Settings for the simulation of turbines consist of the airfoil S809 and S809gx.
\n
\n
\n
4. CFD simulation
\n
To visualize the improved aerodynamic behavior in the optimized airfoil compared to the reference, the CFD simulations were performed.
\n
The meshes for two airfoils were generated with Gmsh [17] (\nFigure 12\n). The Gmsh tool offers a certain tool for mesh refinement so that the validity of the mesh results can be assured. As the six decimals of accuracy are used, the changes are only appreciated by the fourth digit with the maximum of 0.1% [18].
\n
The software OpenFOAM® uses SimpleFOAM solver with Spalart-Allmaras turbulence model for Reynolds-averaged Navier–Stokes (RANS) equations as the governing equation. It was developed for the aerospace flow problems including wall-bounded flow for boundary layers under the adverse pressure gradients.
\n
The transport equation with the working variable \n\n\nυ\n~\n\n\n is mentioned in Ref. [19]. In model assumption, the eddy viscosity is considered as the capability of turbulent flow to transport momentum. The production term is assumed to be increased linearly with the magnitude of the vorticity (S). The right-hand side of the equation also includes the third term, which is the destruction term. The faster-decaying motion in the outer part of the boundary layer is expressed with the function (fw\n). The detailed derivation and explanation about equations are found in Ref. [19].
\n
The solver visualized the following airflow with ParaView®. The velocity distribution at the outer flow and boundary layer flow distributions are visualized through the aforementioned solution method. The flow time was set to be 1000 with the time interval of 50. The dynamic stall regime angle of attack was at around 22°; the outer flow TSR was 1.5 when incoming velocity was 27.7 m/s.
\n
In general, the reference airfoil shows larger stall area with more laminar separation bubble occurrences than the optimized one. At the time point T = 650, the difference between two airfoils was clearly visualized. At T = 650, the slope of the stall area is more smooth at the optimized airfoil with the smaller total area (\nFigure 13\n).
\n
The laminar separation bubbles are only found in the reference when the pressure gradient is less drastic at the optimized one. This is supported by the pressure visualization in \nFigure 14\n. The adverse pressure gradient difference was higher at the reference, and the area with the minus pressure range is largely found at the reference. This milder stall and separation effects explain the smaller drag at the optimized airfoil in dynamic stall regime.
\n
\n
\n
5. Conclusion
\n
The airfoil optimization using GA for higher aerodynamic efficiency and larger laminar boundary layer is achieved. Furthermore, the turbine power performance increment and air flow visualization of reduced stall from the optimized airfoil are proven via simulation. The higher GR and transition point values due to the reduced drag from expanded laminar boundary layer region are presented for the optimized airfoil. The boundary layer characteristics such as diminished skin-friction coefficients and higher transition point values over all flow regimes are found to be the reason behind the improved aerodynamics of the optimized airfoil. The results present the contribution of specifically airfoil shape for aerodynamic efficiency and modified boundary layer distribution on HAWT performance improvement including an effective lifting of the blades and rotor rotation.
\n
\n
Acknowledgments
\n
This study was supported by BB21 project of Busan Metropolitan City (BMC).
\n
\n',keywords:"aerodynamics, airfoil, drag and lift, separation, transition",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/57229.pdf",chapterXML:"https://mts.intechopen.com/source/xml/57229.xml",downloadPdfUrl:"/chapter/pdf-download/57229",previewPdfUrl:"/chapter/pdf-preview/57229",totalDownloads:1459,totalViews:332,totalCrossrefCites:0,dateSubmitted:"April 4th 2017",dateReviewed:"September 8th 2017",datePrePublished:"December 20th 2017",datePublished:"February 14th 2018",dateFinished:"October 16th 2017",readingETA:"0",abstract:"This chapter describes the method of airfoil optimization considering boundary layer for aerodynamic efficiency increment. The advantages of laminar boundary layer expansion in airfoil of horizontal axis wind turbine (HAWT) blades are presented as well. The genetic algorithm (GA) optimization interfaced with the flow solver XFOIL was used with multi-objective function. The power performance of turbine with optimized airfoil was calculated by using blade element method (BEM) in software QBlade. The CFD simulation from OpenFOAM® with Spalart-Allmaras turbulence model showed the visualized airflow. The optimized airfoil shows enlarged laminar boundary layer region in all flow regime with a higher aerodynamic efficiency and the increased gliding ratio (GR). The power velocity and annual energy production (AEP) curves show the performance improvement of wind turbine with the optimized airfoil. The boundary layer thickness and skin-friction coefficient values support the decreased drag of the optimized airfoil. The smaller laminar separation bubbles and reduced stall regime of CFD simulations illustrate the desirable aerodynamics of the resulted airfoil.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/57229",risUrl:"/chapter/ris/57229",signatures:"Youjin Kim, Ali Al-Abadi and Antonio Delgado",book:{id:"6150",type:"book",title:"Flight Physics",subtitle:"Models, Techniques and Technologies",fullTitle:"Flight Physics - Models, Techniques and Technologies",slug:"flight-physics-models-techniques-and-technologies",publishedDate:"February 14th 2018",bookSignature:"Konstantin Volkov",coverURL:"https://cdn.intechopen.com/books/images_new/6150.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-953-51-3808-2",printIsbn:"978-953-51-3807-5",pdfIsbn:"978-953-51-4047-4",isAvailableForWebshopOrdering:!0,editors:[{id:"118184",title:"Dr.",name:"Konstantin",middleName:null,surname:"Volkov",slug:"konstantin-volkov",fullName:"Konstantin Volkov"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"208318",title:"M.Sc.",name:"Youjin",middleName:null,surname:"Kim",fullName:"Youjin Kim",slug:"youjin-kim",email:"youjin.kim@fau.de",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Erlangen-Nuremberg",institutionURL:null,country:{name:"Germany"}}},{id:"208320",title:"Dr.",name:"Ali",middleName:null,surname:"Al-Abadi",fullName:"Ali Al-Abadi",slug:"ali-al-abadi",email:"Ali.Al-Abadi@sgb-smit.group",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"208321",title:"Prof.",name:"Antonio",middleName:null,surname:"Delgado",fullName:"Antonio Delgado",slug:"antonio-delgado",email:"antonio.delgado@fau.de",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Genetic Algorithm optimization for airfoil",level:"1"},{id:"sec_3",title:"3. The optimized airfoil",level:"1"},{id:"sec_4",title:"4. CFD simulation",level:"1"},{id:"sec_5",title:"5. Conclusion",level:"1"},{id:"sec_6",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'\nJames F. Manwell, Jon G. McGowan, Anthony L. Rogers. Wind Energy Explained: Theory, Design and Application,. 2nd ed. UK: Wiley; 2009. 704 p. ISBN: 978-0-470-01500-1\n'},{id:"B2",body:'\nSmeaton J. Reports of the Late John Smeaton, F.R.S., Made on Various Occasions, in the Course of his Employment as a Civil Engineer. 2nd ed. M. Taylor: London, UK; 1837 556 p\n'},{id:"B3",body:'\nOtto Lilienthal. Birdflight as the Basis of Aviation: A Contribution Towards a System of Aviation. 1st ed. United States: Markowski International Publishers; 2000. 151 p. ISBN: 0938716581\n'},{id:"B4",body:'\nPrandtl L, Tietjens OG. Applied Hydro- and Aeromechanics (Dover Books on Aeronautical Engineering). United States: Dover Publications; 2012. 336 p 048660375X\n'},{id:"B5",body:'\nMichael J. Rycroft, Wei Shyy Editors. A History of Aerodynamics: And its Impact on Flying Machines. Cambridge Aerospace Series. new ed. United Kingdom: Cambridge University Press; 2012. 336 p. ISBN: 048660375X\n'},{id:"B6",body:'\nJacobs, Eastman N. (National Advisory Committee for Aeronautics). NASA Technical Reports Server [Internet]. 1939 [Updated: 1996]. Available from: https://ntrs.nasa.gov/search.jsp?R=19930092782\n\n'},{id:"B7",body:'\nTangler JL, Somers DM. NREL airfoil families for HAWT’s. In: WIND POWER. Washington, DC; Colorado, U.S: National Renewable Energy Laboratory (NREL); 1995; p. 117–123\n'},{id:"B8",body:'\nTimmer WA, van Rooij RPJOM. Summary of the Delft University wind turbine dedicated airfoils. In: ASME 2003 Wind Energy Symposium; January 6–9, 2003; Reno, Nevada, USA. ASME; 2003. WIND2003–352, pp. 11–21. DOI: 10.1115/WIND2003-352\n'},{id:"B9",body:'\nFuglsang P, Bak C. Design and verification of the NewRisø-A1 airfoil family for wind turbines. In: A Collection of the 2001 ASME Wind Energy Symposium Technical Papers at the 39. AIAA Aerospace Sciences Meeting and Exhibit. AIAA-2001-0028. United States: American Institute of Aeronautics and Astronautics; American Society of Mechanical Engineers; 2001. p. 81–91. ISBN: 1-56347-476-X\n'},{id:"B10",body:'\nGrasso F. Usage of numerical optimization in wind turbine Airfoil design. In: Proceedings, 28th AIAA Applied Aerodynamics Conference. Journal of Aircraft; 28 June-1 July 29 2010; Chicago, IL, USA; The American Institute of Aeronautics and Astronautics (AIAA); 2011. 2010–4404\n'},{id:"B11",body:'\nSchlichting H, Gersten K. Boundary-Layer Theory. Berlin, Heidelberg: Springer; 2017. 805 p. DOI: 10.1007/978-3-662-52919-5\n'},{id:"B12",body:'\nMuljadi E, Pierce K, Migliore P. Control strategy for variable-speed, stall-regulated wind turbines. In: 1998 American Controls Conference; 06/24/1998-06/26/1998; Philadelphia, PA (US). Golden, Colorado: National Renewable Energy Lab., Golden, CO (United States); 1998. ark:/67531/metadc690735\n'},{id:"B13",body:'\nMitsuo Gen, Runwei Cheng. Genetic Algorithms and Engineering Optimization. Copyright (C) 2000 John Wiley & Sons, Inc. Published Online: 12 NOV 2007; ISBN: 978-0-471-31531-5; p. 512\n'},{id:"B14",body:'\nKim Y, Al-Abadi A, Delgado A. Strategic blade shape optimization for aerodynamic performance improvement of wind turbines. In: ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition, Volume 9: Oil and Gas Applications; Supercritical CO2 Power Cycles; Wind Energy; June 13–17, 2016; Seoul, South Korea. ASME; 2016. Paper No. GT2016–56836. pp. V009T46A009. 10 pages. DOI: 10.1115/GT2016-56836\n'},{id:"B15",body:'\nMueller TJ. Low Reynolds Number Aerodynamics. 1st ed. Berlin Heidelberg: Springer-Verlag; 1989. 451 p. DOI: 10.1007/978-3-642-84010-4\n'},{id:"B16",body:'\nBangga G, Lutz T, Jost E, Kraemer E. CFD studies on rotational augmentation at the inboard sections of a 10 MW wind turbine rotor. Journal of Renewable and Sustainable Energy. 2017;9:023304 http://dx.doi.org/10.1063/1.4978681\n\n'},{id:"B17",body:'\nChristophe Geuzaine and Jean-François Remacle. A three-dimensional finite element mesh generator with built-in pre- and post-processing facilities [Internet]. [Updated: version 3.0.3, June 23 2017]. Available from: http://gmsh.info\n\n'},{id:"B18",body:'\nSánchez SJR. Analysis of flow separation over aerodynamic airfoils [thesis]. Madrid, Spain: Universidad Carlos III De Madrid Escuela Politécnica Superior; 2014. 72 p Available from: https://core.ac.uk/download/pdf/44310532.pdf\n\n'},{id:"B19",body:'\nDeck S, Duveau P, d’Espiney P, Guillen P. Development and application of Spalart-Allmaras one equation turbulence model to three-dimensional supersonic complex configurations. Aerospace Science and Technology, DOI. 2002;6(3):171-183 https://doi.org/10.1016/S1270-9638(02)01148-3\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Youjin Kim",address:"youjin.kim@fau.de",affiliation:'
Institute of Fluid Mechanics, FAU Erlangen-Nürnberg, Germany
Institute of Fluid Mechanics, FAU Erlangen-Nürnberg Busan Campus, South Korea
Institute of Fluid Mechanics, FAU Erlangen-Nürnberg, Germany
Institute of Fluid Mechanics, FAU Erlangen-Nürnberg Busan Campus, South Korea
'}],corrections:null},book:{id:"6150",type:"book",title:"Flight Physics",subtitle:"Models, Techniques and Technologies",fullTitle:"Flight Physics - Models, Techniques and Technologies",slug:"flight-physics-models-techniques-and-technologies",publishedDate:"February 14th 2018",bookSignature:"Konstantin Volkov",coverURL:"https://cdn.intechopen.com/books/images_new/6150.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-953-51-3808-2",printIsbn:"978-953-51-3807-5",pdfIsbn:"978-953-51-4047-4",isAvailableForWebshopOrdering:!0,editors:[{id:"118184",title:"Dr.",name:"Konstantin",middleName:null,surname:"Volkov",slug:"konstantin-volkov",fullName:"Konstantin Volkov"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"414763",title:"Dr.",name:"Venkanna",middleName:null,surname:"Banothu",email:"venky.bt@gmail.com",fullName:"Venkanna Banothu",slug:"venkanna-banothu",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"78421",title:"Effect of Biotic and Abiotic Stresses on Plant Metabolic Pathways",slug:"effect-of-biotic-and-abiotic-stresses-on-plant-metabolic-pathways",abstract:"Plants are prone to encounter some environmental stresses that include both biotic and abiotic. Plants in response to these stress conditions alter their metabolism at the genetic level with consequential effects at the metabolite production. Phenolic compounds, which are secondary metabolites are one such chemical entity which plays a significant role in various physiological processes of the plant. They are mainly formed by three different types of metabolic pathways that produce phenyl propanoid derivatives, flavonoids, terpenoids based on the needs of the plant and the rate of their production is solely dictated by the type of stress condition. A number of phenolic compounds like phytoalexins, phytoanticipins and nematicides exhibit negative response to biotic stress against several soil borne pathogens and nematodes. But some of the phenolic compounds like acetosyringone, umbelliferone, vanillyl alcohol, p-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, apigenin and luteolin are found to exhibit beneficial effects to plants by encouraging rhizosphere formation particularly in Leguminosae family. Some of the ROS produced in various stress conditions are effectively dealt by various phenolics with antioxidant activity like hydroxyl benzoic acids and hydroxyl cinnamic acids. As the in vivo production of phenolics in plants is influenced by external factors it can certainly provide information for the adoption of agronomic practices to yield the full befits of commercial exploitation. 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UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
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Chls are located in the membrane of thylakoids where they constitute the two photosystems (PSII and PSI) of terrestrial plants, responsible for both light absorption and transduction of chemical energy via photosynthesis. The high efficiency of photosystems in terms of light absorption correlates with the need to protect themselves against absorption of excess light, a process that leads to the so-called photoinhibition. Dynamic photoinhibition consists of the downregulation of photosynthesis quantum yield and a series of photo-protective mechanisms aimed to reduce the amount of light reaching the chloroplast and/or to counteract the production of reactive oxygen species (ROS) that can be grouped in: (i) the first line of chloroplast defence: non-photochemical quenching (NPQ), that is, the dissipation of excess excitation light as heat, a process that takes place in the external antennae of PSII and in which other pigments, that is carotenoids, are directly involved; (ii) the second line of defence: enzymatic antioxidant and antioxidant molecules that scavenge the generated ROS; alternative electron transport (cyclic electron transport, pseudo-cyclic electron flow, chlororespiration and water-water cycle) can efficiently prevent the over-reduction of electron flow, and reduced ferredoxin (Fd) plays a key role in this context.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Lucia Guidi, Massimiliano Tattini and Marco Landi",authors:[{id:"198635",title:"Prof.",name:"Lucia",middleName:null,surname:"Guidi",slug:"lucia-guidi",fullName:"Lucia Guidi"},{id:"199774",title:"Dr.",name:"Massimiliano",middleName:null,surname:"Tattini",slug:"massimiliano-tattini",fullName:"Massimiliano Tattini"},{id:"199775",title:"Dr.",name:"Marco",middleName:null,surname:"Landi",slug:"marco-landi",fullName:"Marco Landi"}]},{id:"54601",doi:"10.5772/67955",title:"Chlorophyll as Photosensitizer in Dye-Sensitized Solar Cells",slug:"chlorophyll-as-photosensitizer-in-dye-sensitized-solar-cells",totalDownloads:2918,totalCrossrefCites:8,totalDimensionsCites:15,abstract:"Chlorophyll, being the most abundant pigment that commonly found in plants, bacteria, bryophytes and algae, plays a vital role in photosynthesis. Chlorophylls are natural pigments and therefore safe, environmental friendly, easily available and cheap. Chlorophyll has been experimented to function as a photosensitizer in dye-sensitized solar cells (DSSCs) as DSSCs mimic the photosynthesis process in green plants. DSSC was first developed by Gratzel in 1991 and since then has gained tremendous attention as its fabrication is cheap and easy. A DSSC basically comprises a semiconductor that has been soaked in sensitizing dye (chlorophyll), a counter electrode, and an electrolyte containing a redox mediator. The dye absorbs light, which is transformed into electricity. Chlorophyll can be extracted from the leaves of pomegranate, bougainvillea, papaya, Pandanus amaryllifolius, spinach, green grasses, seaweeds, algae and bryophytes. Chlorophyll from these sources has been studied as possible photosensitizers for DSSCs. Most researches done in chlorophyll DSSC use the extracted natural pigments. The type of solvent and pH of the dye solution will also affect the stability of chlorophyll and subsequently the performance of the DSSCs. This chapter will present an inexhaustive overview on DSSCs using chlorophyll as dye.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Abdul Kariem Arof and Teo Li Ping",authors:[{id:"186084",title:"Dr.",name:"Abdul Kariem",middleName:null,surname:"Arof",slug:"abdul-kariem-arof",fullName:"Abdul Kariem Arof"},{id:"199862",title:"Dr.",name:"L.P.",middleName:null,surname:"Teo",slug:"l.p.-teo",fullName:"L.P. Teo"}]},{id:"54681",doi:"10.5772/67991",title:"Effects on the Photosynthetic Activity of Algae after Exposure to Various Organic and Inorganic Pollutants: Review",slug:"effects-on-the-photosynthetic-activity-of-algae-after-exposure-to-various-organic-and-inorganic-poll",totalDownloads:2649,totalCrossrefCites:6,totalDimensionsCites:13,abstract:"Algal studies remain necessary for risk assessment and their utility in ecotoxicology is the evaluation of lethal and sub-lethal toxic effects of potential toxicants on inhabitants of several ecosystems. Effects on algal photosynthetic apparatus caused by various chemical species have been extensively studied. The present chapter summarizes the published data concerning the toxicity of various organic and inorganic pollutants such as oils, pesticides, antifoulants and metals on photosynthesis of aquatic primary producers. Biochemical mode of action resulting in the disruption of photosynthesis depends on the chemical’s nature and the characteristics of the exposed microorganism. Observed differences in response and sensitivity by different species to the same toxicant were attributed to several algal characteristics including photosynthetic capacity, pigment type, cellular lipid and protein content, and cell size. Single species bioassays either for one chemical alone or in mixture have been well reported and tolerance of both marine and freshwater water-column phytoplaktonic species has been examined. Adequate published information on multispecies tests (communities) in laboratory and field studies exists. However, risk assessment on photosynthesis of microbenthic periphyton is inadequate, though it is essential especially for hydrophobic organic molecules. Further studies are required to evaluate the adverse effects of metabolites on aquatic microalgae.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Andreas S. Petsas and Maria C. Vagi",authors:[{id:"200196",title:"Dr.",name:"Andreas",middleName:null,surname:"Petsas",slug:"andreas-petsas",fullName:"Andreas Petsas"},{id:"200198",title:"Dr.",name:"Maria",middleName:null,surname:"Vagi",slug:"maria-vagi",fullName:"Maria Vagi"}]},{id:"54510",doi:"10.5772/67913",title:"Light‐Emitting Diodes: Progress in Plant Micropropagation",slug:"light-emitting-diodes-progress-in-plant-micropropagation",totalDownloads:2153,totalCrossrefCites:2,totalDimensionsCites:12,abstract:"In commercial micropropagation laboratories, the light source is one of the most important factors controlling plant morphogenesis and metabolism of plant cells and tissue and organ cultures. Lamp manufacturers have begun to rate lamps specifically for plant needs. The traditional light source used for in vitro propagation is fluorescent lamps (FLs). However, power consumption in FL use is expensive and produces a wide range of wavelengths (350–750 nm) unnecessary for plant development. Light‐emitting diodes (LEDs) have recently emerged as an alternative for commercial micropropagation. The flexibility of matching LED wavelengths to plant photoreceptors may provide more optimal production, influencing plant morphology and chlorophyll content. Although previous reports have confirmed physiological effects of LED light quality on morphogenesis and growth of several plantlets in vitro, these study results showed that LED light is more suitable for plant morphogenesis and growth than FLs. However, the responses vary according to plant species. This chapter describes the applications and benefits of LED lamps on chlorophyll in plant micropropagation. Two study cases are exposed, Anthurium (Anthurium andreanum) and moth orchids (Phalaenopsisis sp.), both species with economic importance as ornamental plants, where LEDs have a positive effect on in vitro development and chlorophyll content.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Jericó J. Bello‐Bello, Juan A. Pérez‐Sato, Carlos A. Cruz‐Cruz and\nEduardo Martínez‐Estrada",authors:[{id:"197218",title:"Dr.",name:"Jericó Jabín",middleName:null,surname:"Bello Bello",slug:"jerico-jabin-bello-bello",fullName:"Jericó Jabín Bello Bello"},{id:"197368",title:"MSc.",name:"Eduardo",middleName:null,surname:"Martínez Estrada",slug:"eduardo-martinez-estrada",fullName:"Eduardo Martínez Estrada"},{id:"197369",title:"Dr.",name:"Carlos Alberto",middleName:null,surname:"Cruz Cruz",slug:"carlos-alberto-cruz-cruz",fullName:"Carlos Alberto Cruz Cruz"},{id:"205358",title:"Dr.",name:"Juan Antonio",middleName:null,surname:"Pérez-Sato",slug:"juan-antonio-perez-sato",fullName:"Juan Antonio Pérez-Sato"}]},{id:"54702",doi:"10.5772/67610",title:"Effects of pH and Phosphorus Concentrations on the Chlorophyll Responses of Salvia chamelaeagnea (Lamiaceae) Grown in Hydroponics",slug:"effects-of-ph-and-phosphorus-concentrations-on-the-chlorophyll-responses-of-salvia-chamelaeagnea-lam",totalDownloads:1481,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Salvia chamelaeagnea (Lamiaceae) is a slow growing water‐wise evergreen shrub originating from the western province of South Africa. It is an attractive landscape, and S. chamelaeagnea is a medicinal plant. It is important to develop enhanced cultivation protocols that could result in high yield and high‐quality medicinal materials. Chlorophyll is a fundamental part of the light‐dependent reactions of the photosynthesis process. This chapter investigates the effects of four phosphorus concentrations and three pH levels of supplied irrigated water on the production of chlorophyll A, chlorophyll B, total chlorophyll, leaf colour and the nutrient uptake of S. chamelaeagnea grown in hydroponics over an 8‐week period at the Cape Peninsula University of Technology. The treatments of pH 4, pH 6 and pH 8 at 31, 90, 150 and 210 ppm of phosphorus were received by 12 groups of plants and were replicated 10 times. The results indicated that at pH 4, P fertilization significantly (P < 0.05) induced a higher chlorophyll production of S. chamelaeagnea grown in hydroponics compared to other pH treatments (pH 8 and pH 6).",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Kerwin Lefever, Charles P. Laubscher, Patrick A. Ndakidemi and Felix\nNchu",authors:[{id:"200292",title:"Dr.",name:"Felix",middleName:null,surname:"Nchu",slug:"felix-nchu",fullName:"Felix Nchu"},{id:"200819",title:"Prof.",name:"Charles",middleName:"Petrus",surname:"Petrus Laubscher",slug:"charles-petrus-laubscher",fullName:"Charles Petrus Laubscher"},{id:"201292",title:"Mr.",name:"Kerwin",middleName:null,surname:"Lefever",slug:"kerwin-lefever",fullName:"Kerwin Lefever"},{id:"201293",title:"Prof.",name:"Patrick A.",middleName:null,surname:"Ndakedemi",slug:"patrick-a.-ndakedemi",fullName:"Patrick A. Ndakedemi"}]}],mostDownloadedChaptersLast30Days:[{id:"54681",title:"Effects on the Photosynthetic Activity of Algae after Exposure to Various Organic and Inorganic Pollutants: Review",slug:"effects-on-the-photosynthetic-activity-of-algae-after-exposure-to-various-organic-and-inorganic-poll",totalDownloads:2649,totalCrossrefCites:6,totalDimensionsCites:13,abstract:"Algal studies remain necessary for risk assessment and their utility in ecotoxicology is the evaluation of lethal and sub-lethal toxic effects of potential toxicants on inhabitants of several ecosystems. Effects on algal photosynthetic apparatus caused by various chemical species have been extensively studied. The present chapter summarizes the published data concerning the toxicity of various organic and inorganic pollutants such as oils, pesticides, antifoulants and metals on photosynthesis of aquatic primary producers. Biochemical mode of action resulting in the disruption of photosynthesis depends on the chemical’s nature and the characteristics of the exposed microorganism. Observed differences in response and sensitivity by different species to the same toxicant were attributed to several algal characteristics including photosynthetic capacity, pigment type, cellular lipid and protein content, and cell size. Single species bioassays either for one chemical alone or in mixture have been well reported and tolerance of both marine and freshwater water-column phytoplaktonic species has been examined. Adequate published information on multispecies tests (communities) in laboratory and field studies exists. However, risk assessment on photosynthesis of microbenthic periphyton is inadequate, though it is essential especially for hydrophobic organic molecules. Further studies are required to evaluate the adverse effects of metabolites on aquatic microalgae.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Andreas S. Petsas and Maria C. Vagi",authors:[{id:"200196",title:"Dr.",name:"Andreas",middleName:null,surname:"Petsas",slug:"andreas-petsas",fullName:"Andreas Petsas"},{id:"200198",title:"Dr.",name:"Maria",middleName:null,surname:"Vagi",slug:"maria-vagi",fullName:"Maria Vagi"}]},{id:"54510",title:"Light‐Emitting Diodes: Progress in Plant Micropropagation",slug:"light-emitting-diodes-progress-in-plant-micropropagation",totalDownloads:2153,totalCrossrefCites:2,totalDimensionsCites:12,abstract:"In commercial micropropagation laboratories, the light source is one of the most important factors controlling plant morphogenesis and metabolism of plant cells and tissue and organ cultures. Lamp manufacturers have begun to rate lamps specifically for plant needs. The traditional light source used for in vitro propagation is fluorescent lamps (FLs). However, power consumption in FL use is expensive and produces a wide range of wavelengths (350–750 nm) unnecessary for plant development. Light‐emitting diodes (LEDs) have recently emerged as an alternative for commercial micropropagation. The flexibility of matching LED wavelengths to plant photoreceptors may provide more optimal production, influencing plant morphology and chlorophyll content. Although previous reports have confirmed physiological effects of LED light quality on morphogenesis and growth of several plantlets in vitro, these study results showed that LED light is more suitable for plant morphogenesis and growth than FLs. However, the responses vary according to plant species. This chapter describes the applications and benefits of LED lamps on chlorophyll in plant micropropagation. Two study cases are exposed, Anthurium (Anthurium andreanum) and moth orchids (Phalaenopsisis sp.), both species with economic importance as ornamental plants, where LEDs have a positive effect on in vitro development and chlorophyll content.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Jericó J. Bello‐Bello, Juan A. Pérez‐Sato, Carlos A. Cruz‐Cruz and\nEduardo Martínez‐Estrada",authors:[{id:"197218",title:"Dr.",name:"Jericó Jabín",middleName:null,surname:"Bello Bello",slug:"jerico-jabin-bello-bello",fullName:"Jericó Jabín Bello Bello"},{id:"197368",title:"MSc.",name:"Eduardo",middleName:null,surname:"Martínez Estrada",slug:"eduardo-martinez-estrada",fullName:"Eduardo Martínez Estrada"},{id:"197369",title:"Dr.",name:"Carlos Alberto",middleName:null,surname:"Cruz Cruz",slug:"carlos-alberto-cruz-cruz",fullName:"Carlos Alberto Cruz Cruz"},{id:"205358",title:"Dr.",name:"Juan Antonio",middleName:null,surname:"Pérez-Sato",slug:"juan-antonio-perez-sato",fullName:"Juan Antonio Pérez-Sato"}]},{id:"54559",title:"Introductory Chapter: Chlorophyll Molecules and Their Technological Relevance",slug:"introductory-chapter-chlorophyll-molecules-and-their-technological-relevance",totalDownloads:1630,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Maria Isabel Queiroz, Andrêssa Silva Fernandes, Mariany Costa\nDeprá, Eduardo Jacob-Lopes and Leila Queiroz Zepka",authors:[{id:"171980",title:"Dr.",name:"Eduardo",middleName:null,surname:"Jacob-Lopes",slug:"eduardo-jacob-lopes",fullName:"Eduardo Jacob-Lopes"},{id:"200454",title:"Dr.",name:"Andrêssa",middleName:null,surname:"Fernandes",slug:"andressa-fernandes",fullName:"Andrêssa Fernandes"},{id:"200455",title:"Dr.",name:"Mariany",middleName:null,surname:"Deprá",slug:"mariany-depra",fullName:"Mariany Deprá"},{id:"200457",title:"Prof.",name:"Maria Isabel",middleName:null,surname:"Queiroz",slug:"maria-isabel-queiroz",fullName:"Maria Isabel Queiroz"},{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka"}]},{id:"54601",title:"Chlorophyll as Photosensitizer in Dye-Sensitized Solar Cells",slug:"chlorophyll-as-photosensitizer-in-dye-sensitized-solar-cells",totalDownloads:2918,totalCrossrefCites:8,totalDimensionsCites:15,abstract:"Chlorophyll, being the most abundant pigment that commonly found in plants, bacteria, bryophytes and algae, plays a vital role in photosynthesis. Chlorophylls are natural pigments and therefore safe, environmental friendly, easily available and cheap. Chlorophyll has been experimented to function as a photosensitizer in dye-sensitized solar cells (DSSCs) as DSSCs mimic the photosynthesis process in green plants. DSSC was first developed by Gratzel in 1991 and since then has gained tremendous attention as its fabrication is cheap and easy. A DSSC basically comprises a semiconductor that has been soaked in sensitizing dye (chlorophyll), a counter electrode, and an electrolyte containing a redox mediator. The dye absorbs light, which is transformed into electricity. Chlorophyll can be extracted from the leaves of pomegranate, bougainvillea, papaya, Pandanus amaryllifolius, spinach, green grasses, seaweeds, algae and bryophytes. Chlorophyll from these sources has been studied as possible photosensitizers for DSSCs. Most researches done in chlorophyll DSSC use the extracted natural pigments. The type of solvent and pH of the dye solution will also affect the stability of chlorophyll and subsequently the performance of the DSSCs. This chapter will present an inexhaustive overview on DSSCs using chlorophyll as dye.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Abdul Kariem Arof and Teo Li Ping",authors:[{id:"186084",title:"Dr.",name:"Abdul Kariem",middleName:null,surname:"Arof",slug:"abdul-kariem-arof",fullName:"Abdul Kariem Arof"},{id:"199862",title:"Dr.",name:"L.P.",middleName:null,surname:"Teo",slug:"l.p.-teo",fullName:"L.P. Teo"}]},{id:"54702",title:"Effects of pH and Phosphorus Concentrations on the Chlorophyll Responses of Salvia chamelaeagnea (Lamiaceae) Grown in Hydroponics",slug:"effects-of-ph-and-phosphorus-concentrations-on-the-chlorophyll-responses-of-salvia-chamelaeagnea-lam",totalDownloads:1482,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Salvia chamelaeagnea (Lamiaceae) is a slow growing water‐wise evergreen shrub originating from the western province of South Africa. It is an attractive landscape, and S. chamelaeagnea is a medicinal plant. It is important to develop enhanced cultivation protocols that could result in high yield and high‐quality medicinal materials. Chlorophyll is a fundamental part of the light‐dependent reactions of the photosynthesis process. This chapter investigates the effects of four phosphorus concentrations and three pH levels of supplied irrigated water on the production of chlorophyll A, chlorophyll B, total chlorophyll, leaf colour and the nutrient uptake of S. chamelaeagnea grown in hydroponics over an 8‐week period at the Cape Peninsula University of Technology. The treatments of pH 4, pH 6 and pH 8 at 31, 90, 150 and 210 ppm of phosphorus were received by 12 groups of plants and were replicated 10 times. The results indicated that at pH 4, P fertilization significantly (P < 0.05) induced a higher chlorophyll production of S. chamelaeagnea grown in hydroponics compared to other pH treatments (pH 8 and pH 6).",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Kerwin Lefever, Charles P. Laubscher, Patrick A. Ndakidemi and Felix\nNchu",authors:[{id:"200292",title:"Dr.",name:"Felix",middleName:null,surname:"Nchu",slug:"felix-nchu",fullName:"Felix Nchu"},{id:"200819",title:"Prof.",name:"Charles",middleName:"Petrus",surname:"Petrus Laubscher",slug:"charles-petrus-laubscher",fullName:"Charles Petrus Laubscher"},{id:"201292",title:"Mr.",name:"Kerwin",middleName:null,surname:"Lefever",slug:"kerwin-lefever",fullName:"Kerwin Lefever"},{id:"201293",title:"Prof.",name:"Patrick A.",middleName:null,surname:"Ndakedemi",slug:"patrick-a.-ndakedemi",fullName:"Patrick A. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:9,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",slug:"ana-isabel-flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",slug:"christian-palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",slug:"attilio-rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",slug:"yanfei-(jacob)-qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"8",type:"subseries",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11404,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",slug:"hitoshi-tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",slug:"marcus-vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},publishedBooks:{paginationCount:0,paginationItems:[]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/414763",hash:"",query:{},params:{id:"414763"},fullPath:"/profiles/414763",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()