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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"630",leadTitle:null,fullTitle:"Epilepsy in Children - Clinical and Social Aspects",title:"Epilepsy in Children",subtitle:"Clinical and Social Aspects",reviewType:"peer-reviewed",abstract:'Epilepsy is a neurological condition that accompanies mankind probably since its inception. About 400 years before Christ, the disease was already known by Hippocrates, who wrote the book "On The Sacred Disease". Classically, epilepsy has been defined as a chronic condition characterized by an enduring propensity to generate seizures, which are paroxysmal occurring episodes of abnormal excessive or synchronous neuronal activity in the brain. Out of all brain disorders, epilepsy is the one that offers a unique opportunity to understand normal brain functions as derived from excessive dysfunction of neuronal circuits, because the symptoms of epileptic seizures are not the result of usual loss of function that accompanies many disease that affect the brain. I am therefore extremely honoured to present this book. The 15 very interesting chapters of the book cover various fields in epileptology - they encompass the etiology and pathogenesis of the disease, clinical presentation with special attention to the epileptic syndromes of childhood, principles of medical management, surgical approaches, as well as social aspects of the disease.',isbn:null,printIsbn:"978-953-307-681-2",pdfIsbn:"978-953-51-6487-6",doi:"10.5772/1140",price:119,priceEur:129,priceUsd:155,slug:"epilepsy-in-children-clinical-and-social-aspects",numberOfPages:250,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"d702a3c2d86a233aeb0476312e5c73e1",bookSignature:"Željka Petelin Gadže",publishedDate:"September 15th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/630.jpg",numberOfDownloads:66254,numberOfWosCitations:21,numberOfCrossrefCitations:6,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:33,numberOfDimensionsCitationsByBook:2,hasAltmetrics:0,numberOfTotalCitations:60,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 19th 2010",dateEndSecondStepPublish:"November 16th 2010",dateEndThirdStepPublish:"March 23rd 2011",dateEndFourthStepPublish:"April 22nd 2011",dateEndFifthStepPublish:"June 21st 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"46656",title:"Dr.",name:"Zeljka",middleName:null,surname:"Petelin Gadze",slug:"zeljka-petelin-gadze",fullName:"Zeljka Petelin Gadze",profilePictureURL:"https://mts.intechopen.com/storage/users/46656/images/1818_n.jpg",biography:"Assist. Prof. Željka Petelin Gadže, M.D., Ph.D., born on the 11th August 1976 iz Zagreb, Croatia, after graduation on the Medical School of the University of Zagreb, started to work at the Department of Neurology of the Medical School and University Hospital Centre Zagreb, where she specialized in neurology in May 2007, and defended doctoral dissertation “Apoptosis of blood and cerebrospinal fluid lymphocytes in patients with multiple sclerosis” in December 2004. Since 2007 she works at the Referral Centre for Epilepsy of the Ministry of Health and Social Welfare of the Republic of Croatia, and since 2010 she is the head of the Electroencephalographic Laboratory and Division for Minimally Invasive Neurosurgical Treatment of Neurological Diseases at the University Hospital Centre Zagreb. She has published around 90 papers in the field of neurology, and held numerous lectures at domestic and international neurological congresses. 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In 2010, the WHO estimated that 285 million people in the world were visually impaired from all causes [1]. Hereditary retinal disease represents another significant contributor to unavoidable worldwide blindness, with conditions such as retinitis pigmentosa (RP) affecting an estimated 1/4000 people, or 0.025% of the population, often of working age [2]. Representing a heterogenous group of inherited diseases, RP affects the rod and cone photoreceptors (PRs), causing progressive, profound visual impairment, but with relative preservation of the inner retinal architecture [3]. This anatomical region consists of retinal ganglion cells (RGCs) and their nerve axons, which transmit visual information to the brain, along with other regulatory interneurons, such as bipolar, amacrine and horizontal cells, and Müller support cells (Figure 1). Preservation of these structures and the associated retinotopic map has led to RP becoming a model for many forms of visual restorative therapy, in particular, retinal prosthetics.
A schematic demonstrating the anatomy of the eye and organization of the retina. RNFL: retinal nerve fibre layer; RGCs: retinal ganglion cells; RPE: retinal pigment epithelium.
Another significant retinal cause of blindness is age-related macular degeneration (AMD), accounting for 5% globally [1]. It has been projected that, by 2040, this condition alone will affect 288 million people, 3.25% of the predicted global population [4, 5]. Late AMD comprises geographic atrophy (dry) and neovascular (wet) AMD, and is a significant cause of morbidity in the western world, with a prevalence of 2.4% in the UK [6, 7]. While anti-VEGF treatment has revolutionized the treatment of wet AMD, there is currently no treatment for the dry subtype, which results in degeneration of the PR layer and impairment of central vision in 1.3% of the UK population [7].
The concept of retinal prosthetics is centred on the phenomenon of electrically induced subjective visual percepts or ‘phosphenes’. These phosphenes have been elicited by applying electrical currents across the ocular surface since as long ago as the eighteenth century. In the early twentieth century, Förster demonstrated that phosphenes could be elicited in blind patients via direct stimulation of the visual cortex, leading, in 1968, to the first chronic implantation of an intracranial visual prosthesis [8, 9]. In the 1980s, advances in microfabrication, materials engineering and retinal surgery provided a fecund environment for emergence of the field of retinal prosthetics—devices that could deliver direct stimulation to the residual retinal neurons.
In order to create a
There are two types of PR, rod and cone cells, which number ~120 and 6 million respectively in each eye, resulting in an average input of 100 photoreceptors to each of 1.5 million RGCs [10, 11]. Rods are sensitive to low levels of light and are most populous at about 20° eccentricity. The cone cells are responsible for colour vision and function best in bright light. They are most densely concentrated in the foveal region where they are in almost 1:1 ratio with RGCs, beyond which they decline considerably in density [12].
Following the transduction of photic energy into electrical impulses, bipolar cells effectively transmit the information from PRs to RGCs, but may have an excitatory (ON) or inhibitory (OFF) response to hyperpolarisation and are also influenced by the actions of horizontal and amacrine cells, which can introduce lateral inhibition of signals. Each RGC has a centre-surround receptive field organization and its stimulation pattern will depend both on the size of its receptive field, the input stimulation frequency, and whether it is an ‘on-centre’ or ‘off-centre’ cell. Furthermore, RGCs are not functionally homogeneous, with certain cell populations specialized in particular functions and projecting to specific midbrain regions. Most of the 1 million nerve axons of the RGCs pass via the optic nerve to their respective lateral geniculate nucleus (LGN), located within the thalamus. The LGN is a layered structure and each part receives axons from specific ganglion cell types. A degree of visual processing is thought to occur at this point, before projecting on towards the primary visual cortex, where all higher cognitive processing takes place [12].
The processing power of the retina enables us to resolve detail with remarkably high spatial and temporal resolution, across a broad spectrum of contrast and colour. Beyond this, higher neuro-cortical integration allows us to process and recognize objects, words and faces, appreciate distance, orientation and movement, while coordinating our visual interpretations with other sensory inputs and motor outputs. Together this information allows us to decide what is safe or dangerous, fast or slow, attractive or repulsive. All this activity occurs in milliseconds, with a seemingly infinite refresh rate. This phenomenon is reliant on a very complex system that can rapidly capture, assimilate, compress and process an enormous amount of visual information.
Clearly, creating a micro-electronic system, which can come close to replicating the processing capacity of the human visual system, is currently an unrealistic goal. Instead, we must focus on how visual processing software and hardware engineering can be combined to produce a device that can resolve the minimum interpretable visual information such as to be beneficial to patients with profound vision loss.
Simulated prosthetic vision (SPV) studies have been undertaken to try and estimate the optimum spatiotemporal image processing techniques for specific task completion, as well as the basic hardware requirements to best deliver RGC stimulation patterns [13, 14, 15, 16, 17]. SPV studies have extensively investigated the spatial resolution, visual field and contrast required for assorted activities of daily living, concluding that a minimum resolution of ~600–1000 pixels over a visual field 15° × 15° can permit reasonable accuracy in manipulation, recognition, orientation and mobility tasks. The resolution of around 3 pixels/degree2 is similar to that in some currently available photovoltaic retinal prosthetic systems while fields of at least 15° × 15° have been created. However, and disappointingly, there remains a mismatch in the functional aptitude demonstrated by subjects in SPV studies and that in recipients of visual prostheses. This suggests that other factors, such as the effects of behavioural adaptation, perceptual learning and cortical plasticity, as well as the loss of the intrinsic retinal processing capacity, could be critical requisites in the development of a visual restorative system that could deliver appreciable functional value [18, 19].
One of the advantages of a
Another matter that remains unclear is the extent to which the human brain undergoes reorganization following loss of visual sensory input. Both animal and human studies have shown that there is the capacity for neuroplasticity as a functional adaptation to loss of a sensory modality [25, 26, 27]. For example, visual cortical activity has been demonstrated in blind subjects while reading Braille [28, 29]. Other studies of patients undergoing cochlear implant surgery, have shown correlation between the pre-operative auditory organization and activation and subsequent success of the neuroprosthesis [30, 31]. If a method could be developed by which a patient could be assessed for the feasibility of generating interpretable phosphenes, this would enhance patient selection and thus outcomes in this area of visual restoration. Further understanding of the nature of cortical plasticity in sensory loss and how subjects can adapt to a new form of vision with perceptual learning and rehabilitation, is sure to enhance the beneficial effect of visual restorative treatments in the future.
In order to simulate the complex series of events that take place between the outside world and the visual cortex, a prosthesis system needs to perform a specific sequence of actions, namely image capture, processing of the image, delivery of both image data and signal amplification to the microelectrode array, which in turn must deliver a suitable stimulation current (directly or indirectly) to the RGCs. All this must take place with a biocompatible system that can produce adequate stimulation currents without causing degradation to itself or to the target tissue. Furthermore, the device needs to be straightforward to implant, modify or explant, while remaining portable, discreet and fashionable.
Presently, there are two principal means of ‘image capture’ that have found some success in retinal prosthetic systems. The first is to capture information from the visual scene using an external video camera, which is usually glasses-mounted. The video camera then transmits data directly to an external video-processing unit (VPU). The advantage of this approach is not only that it is technically simpler, but also it avoids any impediments to collecting high quality information about the visual scene, thus facilitating any downstream image processing. However, due to the fixed camera position, there is a risk of discrepancy between its orientation and that of the eye, risking inaccuracies in the perceived spatial location of an object of interest following retinal stimulation. Proposed solutions to this problem include both the incorporation of an eye tracker to coordinate the direction of gaze with the stimulation pattern, or placement of the camera system intraocularly, for which there have been some preliminary attempts to design such a system [32].
The second image capture system that has shown promise is the photodiode array device. First developed by the Chow brothers as the artificial silicon retina (ASR), this comprises a passive microphotodiode array, which was intended to intrinsically transform ambient light that falls on it into an electrical current capable of stimulating retinal neurons. The ASR array consists of 5000 interconnected photodiode anodes with individual isolated cathodes, each with an iridium oxide electrode. This method was advantageous in as far as it allowed a large number of pixels to be stimulated simultaneously, it was wireless and also it allowed for precise coordination between the eye position and the projected visual scene [33, 34]. However, in its first iteration, it was unable to deliver sufficient stimulation current to deliver functional results and the parent company,
In some systems, the image processing takes place within an external analyser, which receives a high-quality signal from a camera system and transforms the data into a set of commands to be wirelessly transmitted to the microelectrode array to generate a specific stimulation pattern. In systems such as the Argus II retinal prosthesis, there are only 60 microelectrodes, meaning that even with perfect electrode contact and accurate retinotopic phosphene perception, the image resolution would still be low. As such, there is an emphasis on developing software algorithms that can filter the most relevant parts of a visual scene, before creating simple stimulation configurations that map the object of interest onto the array. This process is known as saliency mapping, and similar algorithmic methods of rapid recognition and segmentation of information have previously been used with success in the form of speech processors for cochlear implants [39, 40, 41, 42].
Simulation studies have shown that by applying transformations, such as edge detection, greyscale histogram equalization, intensity and contrast enhancement, task performance using a low resolution viewing system can be improved (Figure 2). Similarly, software has been developed to allow magnification of areas of interest in the visual scene, or even projection of a simulated object or face onto the array, in response to detection of the respective entity in the captured environment [43, 44]. The intelligent retinal implant system (IRIS) II (
An example of image processing transformations: the image of the bicycle first undergoes edge detection and is converted to greyscale. This is then transformed by circular binarisation into a black-and-white pixelated format. Finally the image is inverted, with the addition of four greyscale levels.
All these types of pre-processing are relevant for devices that do not have intrinsic photosensitivity, but instead rely on external image capture systems. In the case of the photovoltaic systems, there is a greater spatial resolution due to the high density of photodiode-amplifier-electrode units, each of which acts as an independent pixel. In theory, this enables greater intrinsic processing through more localized neuronal stimulation and may also incorporate some downstream processing from the residual retina to select and transmit the most salient visual information to the brain [46, 47].
Delivery of encoded visual information and power to the microelectrode array is generally either wireless (via inductively coupled coils) or directly onto the microphotodiode array via the natural optical system of the eye. In variations of the former approach, there are several considerations that need to be made. Inductive coil systems function through radio-frequency telemetry, whereby an AC current passing through the external coil induces an AC voltage in the internal coil, which can be subsequently be converted into DC power. A capacitor in series with the secondary coil permits amplification of the received voltage by creating a tuned resonance at the transmitter frequency, thus supporting efficient power transfer while minimizing the body’s exposure to radiation. Although the data may be encoded onto the same signal as the power, it is more commonly accomplished with greater effect by using a separate, high frequency coil. The capacity for data and power transfer using this model is sufficient to support the resolution and refresh rate of current systems [48].
Location is an important consideration for an efficient inductive coil system. Many systems utilize a coil system that is similar to that of cochlear implants, with an electronics unit fixed to the bone postauricularly, which communicates with the retinal array via a tunnelled connecting wire. This approach was initially chosen due to the surgical familiarity to otolaryngologists and it allows for good coil contact for coupling. However, due to the prolonged duration of surgery, complex fabrication challenges and apparent reduction in system longevity, some systems have since been modified to incorporate a glasses-mounted transmitting coil which transmits to an implanted subconjunctival receiving coil, which is connected to the array via a sclerotomy. Another approach, as used in the EPI-RET3 implant, involves positioning a receiver coil into the lens capsular bag (following removal of the native lens). This approach still relies on an inductive power and data link, but negates the need for a transscleral wire, which carries a risk of infection and erosion. In addition, this system has a bi-directional enhancement system, which allows for simultaneous stimulation of and recording from the microelectrodes. Feedback from the system enables modification of the stimulation algorithms and patterns to accommodate any residual excitatory and inhibitory signal processing of the retinal neurons [49, 50].
There are several considerations when designing an electrode array to deliver electrical currents to the RGCs in order to replicate the spatial resolution (SR) of the natural retina. These include the electrode material, size, shape, spacing (pitch), tissue contact and the anatomical position of the array.
There are three primary sites for placement of a retinal stimulating microelectrode array (Figure 1): epiretinally (i.e. on the surface of the neurosensory retina), subretinally (i.e. between the retinal pigment epithelium and the degenerated outer retina) or suprachoroidally (i.e. between the sclera and the choroid). The advantage of the epiretinal placement is that the surgical approach is more familiar to vitreoretinal surgeons, allowing safer and easier implantation, adjustment and removal of devices. Furthermore, the interface with the vitreous cavity seems to permit safer heat dispersion. This set-up may be disadvantageous due to the fact that, in order to stimulate the RGCs, the stimulating current must pass through the retinal nerve fibre layer, which may produce ectopic visual percepts elsewhere in the retinotopic map.
In terms of a subretinal system, one proposed advantage is that by mimicking the position of the PRs in the natural retina, some of the stimulating current will pass via the residual bipolar system, exploiting graded response of the inner retinal neurons and thus the natural processing power of the retina. Moreover, it is felt that better electrode-tissue contact will be achieved with the subretinal than with the epiretinal approach. However, it has been noted that, due to underlying degenerative changes, surgical implantation can be difficult, and the longevity of these devices can be more limited [51].
Finally, suprachoroidal devices require a less invasive surgical procedure, which lends itself to easier repair or removal, but trials to date have been complicated by subchoroidal haemorrhage and fibrosis [52]. Due to the distance from the RGCs, these systems tend to require higher stimulation thresholds, leading to greater current dispersion and lowering the achievable SR. Overall, it seems that epiretinal and subretinal approaches have a superior performance in safety and efficacy to suprachoroidal implants. However, with pros and cons to both approaches, there is currently no clear evidence to suggest that, of these latter two, one system offers an overall advantage.
The challenge of electrode size and density is primarily a biological one, in as far as the native PR cells change in type, size, density and downstream signalling depending on their role and location in the retina. For example, cone PRs are, on average 6 μm in diameter, but in the centre of the fovea, they are around 1.5 μm in diameter and densely packed to permit the high resolution of vision that humans usually enjoy [53]. If we consider that normal vision is 20/20, meaning that the minimal angle of resolution at the retina is 1 arcminute, or the spatial frequency (SF) is 60 cycles per degree (cpd), then the SF required to achieve 20/200 (the approximate level of visual impairment) is 6 cpd. Since each degree angle subtended at the human retina is represented by ~280 μm, a SF of 6 cpd would necessitate a maximum pixel size of about 50 μm and, in turn an electrode size and pitch of 25 μm [54, 55]. Therefore, before factors such as electrode contact, dissipation of electrical current or heat are even considered, there is a significant theoretical constraint on the scale of manufacturing required to achieve a resolution corresponding to a visual acuity of 20/200.
Among the smallest electrodes that have undergone human implantation to date are those of the alpha IMS, which are ~50 μm in diameter, with a 70 μm spacing, giving a theoretical maximum VA of about 20/250 [36]. Results have been reported of a grating VA of 3.3 cpd and optotype recognition acuity of 20/546 using this device [56]. The Argus II device has 200 μm electrodes separated by 525 μm, which suggests a theoretical maximum VA of 20/1600. The best result, with grating acuity, has been reported as 20/1262 (just over 1 cpd) with this system [57].
Electrode shape is a factor that may significantly affect the integration of the device by creating an environment where retinal tissue can migrate around the array and create a close interface. Arrays have been designed with sunken chambers or ‘wells’, into which the inner nuclear layer cells have been shown to migrate. Another approach is the three-dimensional pillar array, with protruding electrodes, designed to produce an intimate apposition between the array and the neuronal cell bodies without requiring excessive remodelling of the retina [58].
Size, shape and contact of the electrode at the tissue interface are all important considerations to improve SR, but also have implications to the charge density per unit area. As the electrode size becomes smaller, there is an exponential increase in concentration of the current, which can result in target tissue damage [59]. Therefore there is an onus on finding materials that can permit the charge-injection requirements of neural stimulation, while minimizing conduction of heat or inducing tissue degradation. In addition to this, they must be biocompatible, waterproof and remain operational over an extended lifespan. While the precise electrochemical properties of the electrode-electrolyte interface, the capacitance and charge injection limits of different electrode materials is beyond the scope of this chapter, it is worth noting that new technologies, such as nanocoating, nanotubes and conductive polymers are providing promising developments in electrode fabrication, which may offer significant advantages over the more traditional metallic designs, such as iridium, platinum or titanium-based electrodes [60, 61, 62]. The emerging field of tissue electronics, which is focused on the use of organic conductive and semi-conductive polymer alternatives to inorganic electronic systems, is rapidly advancing. Recently, long-term
The Argus II epiretinal device (
The components of the Argus II retinal prosthesis system (adapted with permission from Second Sight Medical Products).
The Argus II system is implanted using standard pars plana vitrectomy and scleral buckling procedures, and usually the surgery includes removal of the native lens. Following removal of the vitreous and posterior hyaloid face, a conjunctival peritomy is performed and the recti muscles are isolated to allow fixation of an encircling band containing the internal coil and in-built application-specific integrated circuit. A 5 mm sclerotomy is created for insertion of the 60-microelectrode array and the connecting cable. This lies flush on the epiretinal surface and is secured in place using a spring-loaded titanium tack (Figure 4). A scleral allograft (or similar alternative) covers the hermetically-sealed coil and electronics case, which is then re-covered by Tenon’s capsule and conjunctiva, such that the internal components are invisible to the casual observer. To use the device, the external components are worn, including a glasses-mounted camera and external coil, and a portable VPU and power unit [57].
Fundus photograph demonstrating an Argus II microelectrode array
Throughout the 1990s, Humayun demonstrated that low current stimulation of dissected animal retinal tissue could produce localized retinal responses [66]. This was followed by acute epiretinal stimulation experiments of blind human volunteers, with various forms of retinal degeneration. It was shown that stimulation could elicit subjective phosphenes, which in many cases could be accurately localized and resolved to an equivalent acuity of up to 4/200 [67, 68]. In a subsequent series of acute stimulation tests using multielectrode arrays, two patients were able to identify crude forms from discrete patterns of electrical stimulation, using 400 μm electrodes arranged in 3 × 3 or 5 × 5 grids.
These promising results led to the development of the Argus I epiretinal prosthesis, which was the first device to undergo chronic testing in 2002 in six patients with end-stage RP. The Argus I device included a 4 × 4 array, comprising 16 alternating 250 and 500 μm diameter electrodes. The initial device design was based closely on that of cochlear implants, with an electronic unit surgically positioned in a postauricular recess of the temporal bone, from where a connecting cable would be passed along a groove in the bone and communicate with the intraocularly placed array. The external camera and VPU components captured the images, which, once encoded, were wirelessly transmitted via an antenna, that was magnetically held in position over the internal electronic unit. Results showed coarse functional performance was better than chance with the device on, with one patient able to detect light, motion and simple shapes [69, 70, 71]. In another subject, it was recently shown that the device continued to elicit phosphenes sufficient to permit target localization, orientation and mobility performance better than chance with the device on, 10 years postimplantation [72]. The overall safety and longevity of the device, which demonstrated coarse functional outcomes at a safe charge density limit, led to the development of the Argus II system, with a 6 × 10 microelectrode array and an optimized surgical approach.
The phase II multicenter clinical trial for the Argus II retinal prosthesis system began in 2006, enrolling 28 patients with end-stage RP, one with Leber congenital amaurosis and one with choroideremia. The primary endpoints of this study were safety and visual function, while secondary assessments of functionality included activities of daily living, such as orientation and mobility [57, 73, 74].
Witinn 12 months of the start of the trial, there were 18 reported serious adverse events (SAEs) requiring intervention, occurring in 10 of the 30 implanted patients. These included three cases of presumed endophthalmitis, three cases of conjunctival dehiscence, three cases of conjunctival erosion, two cases of hyptony, two arrays requiring re-tacking and one case each of rhegmatogenous retinal detachment, tractional retinal detachment, a retinal tear, corneal opacification and an inflammatory uveitis. The majority of these SAEs (78%) took place within the first 6 months after implantation and they were clustered among the initial 15 patients (72%). The reduction in SAEs in the second half of the trial was ascribed to refinement of both the device and the implantation procedure during the study, such as inclusion of prophylactic intravitreal antibiotics to the surgical protocol. All SAEs were successfully treated; in the cases of hypotony, the subjects required silicone oil tamponade (in one case for retinal detachment), which led to stabilization of the intraocular pressure [57, 73].
At 36 months, there were five additional reported late SAEs, including two further cases of hypotony and one each of infective keratitis, corneal melt and conjunctival erosion. Within this period, only one device required explantation, due to recurrent conjunctival erosion, and no eyes were enucleated [73]. At 5 years, the latest reported time point, there was only one additional SAE, which was a successfully treated retinal detachment, resulting in a total rate of 24 reported SAEs among 12 (40%) of subjects. A total of three devices have been partially or completely removed at the request of the subjects, while a further seven subjects underwent elective repositioning during the trial to improve the contact of the array with the retina [74].
Overall, this is the largest and longest study of a retinal prosthesis system to date, demonstrating an acceptable safety profile and ongoing functionality and biocompatibility in the majority of subjects. Subsequent case series have shown improved safety profiles in parallel with growing surgical familiarity.
There were three objective assessments used to evaluate visual function in the study. Firstly, a ‘square localization’ task, which involved the subject locating a white square displayed on a black background, indicated by touching the monitor. At 1 year, 94% of subjects could perform the task better with the device on than off. This was maintained at 3 years (89%) and 5 years (80.9%). The second task was ‘direction of motion’, which was assessed by asking the subject to indicate the direction of a high-contrast white line as it moved across the monitor. Initially 57% of subjects performed better than chance with the device on, which was once again maintained at 3 and 5 years (56 and 50%), respectively. Of note, these two tests of visual function were not performed in all subjects at the 1-year time point, due to their introduction partway through the study. Finally visual function was assessed using, ‘grating visual acuity’, which consisted of randomly generated widths of black and white gratings in one of four different orientations, displayed for 5 s on a screen. Throughout the study, 27–48% of patients scored better than 2.9 logMAR equivalent (mean 2.5 logMAR), depending on time point, with 38% performing significantly better with the device on than off at year 5. The best result recorded grating acuity was 1.8 logMAR, which approximates to a Snellen acuity of 20/1262 [57, 73, 74, 75]. The results from these tests of visual function are presented in Figure 5.
Results for square localization (A), direction of motion (B) and grating visual acuity (C) at yearly time-points. Credit: da Cruz et al. [
Dorn et al. tested the effect of providing scrambled spatial information to the device compared to one-to-one mapping, to investigate the degree to which the synchronization of multiple electrode stimulation conferred a benefit during motion detection. They found that of the 15 subjects who were able to perform the initial motion detection task better with the device on, 10 (67%) also performed better with one-to-one mapping of spatial information, than with scrambled information [76]. This suggests that the pattern of phosphenes being elicited was important for motion detection, and not that the patient was using the device to detect light, and simply scanning with their head to determine direction.
In the phase II clinical trial, two tests of orientation and mobility were employed. The first involved locating a simulated black door on a white background across the room. The second consisted of the subject following a 6-inch-wide white line on the floor, either configured as a straight line, or with a 90° turn along its length. Successful performance was maintained at ~50 and 70% in each respective task with the device on, which was significantly better than 15–30% success with the device off [57, 73, 74]. Dagnelie et al. found a similar rate of performance success using a real world ‘sidewalk tracking’ test in 27 implanted subjects, showing that 67% performed above chance with the device on, compared to 22% with the system off [77]. Figure 6 illustrates the testing environments for orientation and mobility tasks.
Photographs of subjects performing door finding (A), line tracking (B) and sidewalk tracking (C) tasks. Credit: Humayun et al. [
Arsiero et al. demonstrated, among implanted subjects, recognition of eight simple, solid, white shapes on a black background was significantly better the device on (31%) than off (13%), which improved further to 57% when the shapes were presented as outlines [79]. Luo et al. built upon this, presenting seven implanted subjects with eight high-contrast everyday items, both in the solid and outlined forms. It was found that subjects could identify solid objects to the same degree of accuracy with the device on as they could with the device on in the scrambled mode. Although superior to having the device off, this suggested that subjects were relying on visual cues other than the form presented but the array stimulation pattern. When the shapes were presented in their outlined forms, this significantly improved performance with the device on, above either that of the scrambled mode or with the device off [80].
Another real-world task described by Dagnelie et al., consisted of a ‘sock sorting’ task, in which subjects were asked to sort a randomly arranged collection of 10 black, 10 white and 10 grey socks into separate piles, according to colour. Each test was performed on a wooden table, or on a background of the subject’s choice (i.e. black or white). In both scenarios, the subjects performed significantly better on average with the device on than off [77].
In a study of 21 implanted subjects, da Cruz et al. studied functional form vision by assessing ability to discriminate high-contrast letters. Letters were grouped according to typographical complexity and randomly displayed on a computer screen. Measurements from all subjects revealed a correct identification of 72% of group A (least complex) letters, presented at 30 cm, such that they subtended a visual angle of 41.27°. In the study, 19 and 20 subjects respectively completed the group B and group C letters, correctly identifying 55 and 52% in each instance. In all cases, performance was significantly better with the device turned on than off. A subset of six subjects who identified more than 50% of group A letters in fewer than 60 s went on to complete tests to assess the minimum letter size that could be resolved, while four of these six subjects were also assessed for performance on 2-, 3- and 4-letter word identification. The minimum letter size correctly identified was 0.9 cm, subtending a visual angle of 1.7°. On average, four subjects could identify 6.8 out of 10 words, ranging from 11 to 20 cm in height. In all cases, the performance was significantly better when the device was switched on in standard mode, than when scrambled or off [81]. These results are very promising for the capacity of some patients to achieve good spatial resolution, approaching the theoretical limit of the system.
In a series of experiments using a 3D motion-capture system, Luo et al. measured the ability of five subjects to grasp a white block on a black table (Figure 7). With the device turned on, subjects would successfully initiate and complete a grasping action 74% of the time, compared to 0% with the device off [82, 83]. Unlike other object recognition tasks, this study suggests a good capacity for the system to permit performance of hand-eye coordination tasks in a 3D environment, similar to that of the real-world.
Subject performing prehension task (a) with live infrared motion capture of subject’s hand (b). Credit: Luo et al. [
An important consideration in visual restoration is the extent to which the recipients judge the system to be beneficial in everyday life. The Functional Low-vision Observer Rated Assessment (FLORA) was developed by Geruschat et al. in order to evaluate the impact of partial restoration of ultra-low vision in subjects undergoing Argus II implantation. Initial results using the FLORA tool demonstrated that it was able to provide useful information about the everyday functional benefit of prosthesis-derived visual restoration, as well as identifying areas in which rehabilitation could be utilized to maximize subjective value. At 1 year, the assessment demonstrated an 80% reported positive effect, which dropped to 65% at 3 years. No patients reported a negative effect using this self-reporting tool [84, 85].
There are several other groups across the world using a variety of techniques to develop retinal prosthetic systems. Currently the intelligent retinal implant system (IRIS) II (
The aforementioned Alpha IMS and its successor, the Alpha AMS (
Finally, the Photovoltaic Retinal Implant (PRIMA) bionic vision system (also
Several other groups are also investigating alternative methods of neural stimulation, including optic nerve, cortical and thalamic prostheses [91]. As increasing numbers of patient volunteers undergo implantation with these systems, more data will become available, thus guiding the optimal design characteristics for future generations of devices.
Advancements in visually restorative medicine are not limited to prosthetics, with other regenerative technologies, including stem cells, gene therapy and optogenetics, demonstrating exciting developments in the endeavor to treat blindness [92, 93, 94, 95, 96, 97]. In particular, optogenetics, an approach that is focused on targeting microbial opsin (light-dependent ion channels) to surviving retinal neurons to rescue or restore visual function, has shown exciting results in
The success of the Argus II is representative of the enormous progress that has been made in the field of retinal prosthetics over the past 3 decades. However, there remain significant challenges to be overcome before the concept of ‘bionic vision’ is fully realized. Despite this, retinal prostheses have delivered the most compelling form of artificial vision to date, bearing testimony to the value of close collaboration between engineers, clinicians, patients and industry in pushing the boundaries of what is conceivable, let alone scientifically feasible.
The authors declare no potential conflicts of interest or financial support with respect to the authorship and/or publication of this chapter.
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In food industries, nanoparticles are leading in forming the food with high quality and good nutritive value.",book:{id:"9012",slug:"applications-of-nanobiotechnology",title:"Applications of Nanobiotechnology",fullTitle:"Applications of Nanobiotechnology"},signatures:"Alaa Y. Ghidan and Tawfiq M. Al Antary",authors:null},{id:"68760",doi:"10.5772/intechopen.88744",title:"Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers",slug:"nanofibrous-scaffolds-for-skin-tissue-engineering-and-wound-healing-based-on-synthetic-polymers",totalDownloads:1291,totalCrossrefCites:5,totalDimensionsCites:16,abstract:"Nanofibrous scaffolds are popular materials in all areas of tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. 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In this section, the oxidation of cyclohexane (CH) and benzyl alcohol (BA) to adipic acid (AA), benzaldehyde (BAl), and ammoxidation of 2-methylpyrazine to 2-cyanopyrazine are discussed. Finally, Section 6 describes, main points and outlook are summarized.",book:{id:"5310",slug:"catalytic-application-of-nano-gold-catalysts",title:"Catalytic Application of Nano-Gold Catalysts",fullTitle:"Catalytic Application of Nano-Gold Catalysts"},signatures:"Ahmad Alshammari and Venkata Narayana Kalevaru",authors:[{id:"178547",title:"Dr.",name:"Ahmad",middleName:null,surname:"Alshammari",slug:"ahmad-alshammari",fullName:"Ahmad Alshammari"},{id:"180753",title:"Dr.",name:"V. Narayana",middleName:null,surname:"Kalevaru",slug:"v.-narayana-kalevaru",fullName:"V. Narayana Kalevaru"}]},{id:"50852",doi:"10.5772/63729",title:"Synthesis of Gold Nanoparticles Using Amino Acids by Light Irradiation",slug:"synthesis-of-gold-nanoparticles-using-amino-acids-by-light-irradiation",totalDownloads:3622,totalCrossrefCites:3,totalDimensionsCites:10,abstract:"The synthesis of nanoparticles is generally carried out by chemical reduction, which is effective but uses a number of toxic substances, making the process potentially harmful to the environment. Thus, as part of the search for environmentally friendly or green synthetic methods, this chapter aimed to present the synthesis of gold nanoparticles (AuNPs) using only HAuCl4, Milli-Q water, white light from a xenon lamp, and amino acids. A total of 21 amino acids were studied, and the shapes and sizes of the resultant nanoparticles were evaluated. The products were characterized by ultraviolet-visible (UV-Vis) and fluorescence spectroscopy, zeta potential measurements, and transmission electron microscopy. The synthesis of the AuNPs was successful with 18 amino acids, and the best results were obtained with aspartic acid, arginine, threonine, tryptophan, and valine. The nanoparticles were spherical and their sizes ranged from 5 to 100 nm. Changes in pH were required to improve the stability of the colloidal suspensions.",book:{id:"5310",slug:"catalytic-application-of-nano-gold-catalysts",title:"Catalytic Application of Nano-Gold Catalysts",fullTitle:"Catalytic Application of Nano-Gold Catalysts"},signatures:"Lilia Coronato Courrol and Ricardo Almeida de Matos",authors:[{id:"183894",title:"Ph.D.",name:"Lilia",middleName:null,surname:"Courrol",slug:"lilia-courrol",fullName:"Lilia Courrol"},{id:"185446",title:"MSc.",name:"Ricardo",middleName:null,surname:"Matos",slug:"ricardo-matos",fullName:"Ricardo Matos"}]},{id:"72461",doi:"10.5772/intechopen.92796",title:"Role of Nanobiotechnology in Drug Discovery, Development and Molecular Diagnostic",slug:"role-of-nanobiotechnology-in-drug-discovery-development-and-molecular-diagnostic",totalDownloads:1079,totalCrossrefCites:2,totalDimensionsCites:7,abstract:"Nano-biotechnology has already tested its magnitude in a number of sections of existence science and biotechnology field. It is no longer hyperbole to say that in future, nano-scale method would in reality take the associated science area to the subsequent level. Since, there are technical hurdles present; despite the fact that scientists are giving their great to overcome such problems. Applications of nano-biotechnology have already been discussed in this chapter. Future potential are really associated with innovative amendment of such applications. Despite of some impedance, this technology presents giant hope in the future. It performs most important position in distinct sorts of biomedical application such as shipping of drug, gene therapy, biosensors, biomarkers and molecular imaging. It additionally leads to innovations in this field. The fundamental lookup goal of this discipline would be the innovation of early analysis approach and cure with target-specific remedy therapy. Although there would possibly be some safety worries with admire to the in vivo use of nanoparticles, research are in region to decide the nature and extent of adverse events.",book:{id:"9012",slug:"applications-of-nanobiotechnology",title:"Applications of Nanobiotechnology",fullTitle:"Applications of Nanobiotechnology"},signatures:"Deepak Kumar Dash, Rajni Kant Panik, Anil Kumar Sahu and Vaibhav Tripathi",authors:[{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu"},{id:"250558",title:"Dr.",name:"Deepak Kumar",middleName:null,surname:"Dash",slug:"deepak-kumar-dash",fullName:"Deepak Kumar Dash"},{id:"314683",title:"Dr.",name:"Rajnikant",middleName:null,surname:"Panik",slug:"rajnikant-panik",fullName:"Rajnikant Panik"},{id:"316679",title:"Dr.",name:"Vaibhav",middleName:null,surname:"Tripathi",slug:"vaibhav-tripathi",fullName:"Vaibhav Tripathi"}]}],mostDownloadedChaptersLast30Days:[{id:"68970",title:"Applications of Nanotechnology in Agriculture",slug:"applications-of-nanotechnology-in-agriculture",totalDownloads:3546,totalCrossrefCites:8,totalDimensionsCites:21,abstract:"Nanotechnology has gained intense attention in the recent years due to its wide applications in several areas like medicine, medical drugs, catalysis, energy and materials. Those nanoparticles with small size to large surface area (1–100 nm) have several potential functions. These days, sustainable agriculture is needed. The development of nanochemicals has appeared as promising agents for the plant growth, fertilizers and pesticides. In recent years, the use of nanomaterials has been considered as an alternative solution to control plant pests including insects, fungi and weeds. Several nanomaterials are used as antimicrobial agents in food packing in which several nanoparticles such as silver nanomaterials are in great interest. Many nanoparticles (Ag, Fe, Cu, Si, Al, Zn, ZnO, TiO2, CeO2, Al2O3 and carbon nanotubes) have been reported to have some adverse effects on plant growth apart from the antimicrobial properties. In food industries, nanoparticles are leading in forming the food with high quality and good nutritive value.",book:{id:"9012",slug:"applications-of-nanobiotechnology",title:"Applications of Nanobiotechnology",fullTitle:"Applications of Nanobiotechnology"},signatures:"Alaa Y. Ghidan and Tawfiq M. Al Antary",authors:null},{id:"72461",title:"Role of Nanobiotechnology in Drug Discovery, Development and Molecular Diagnostic",slug:"role-of-nanobiotechnology-in-drug-discovery-development-and-molecular-diagnostic",totalDownloads:1079,totalCrossrefCites:2,totalDimensionsCites:7,abstract:"Nano-biotechnology has already tested its magnitude in a number of sections of existence science and biotechnology field. It is no longer hyperbole to say that in future, nano-scale method would in reality take the associated science area to the subsequent level. Since, there are technical hurdles present; despite the fact that scientists are giving their great to overcome such problems. Applications of nano-biotechnology have already been discussed in this chapter. Future potential are really associated with innovative amendment of such applications. Despite of some impedance, this technology presents giant hope in the future. It performs most important position in distinct sorts of biomedical application such as shipping of drug, gene therapy, biosensors, biomarkers and molecular imaging. It additionally leads to innovations in this field. The fundamental lookup goal of this discipline would be the innovation of early analysis approach and cure with target-specific remedy therapy. Although there would possibly be some safety worries with admire to the in vivo use of nanoparticles, research are in region to decide the nature and extent of adverse events.",book:{id:"9012",slug:"applications-of-nanobiotechnology",title:"Applications of Nanobiotechnology",fullTitle:"Applications of Nanobiotechnology"},signatures:"Deepak Kumar Dash, Rajni Kant Panik, Anil Kumar Sahu and Vaibhav Tripathi",authors:[{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu"},{id:"250558",title:"Dr.",name:"Deepak Kumar",middleName:null,surname:"Dash",slug:"deepak-kumar-dash",fullName:"Deepak Kumar Dash"},{id:"314683",title:"Dr.",name:"Rajnikant",middleName:null,surname:"Panik",slug:"rajnikant-panik",fullName:"Rajnikant Panik"},{id:"316679",title:"Dr.",name:"Vaibhav",middleName:null,surname:"Tripathi",slug:"vaibhav-tripathi",fullName:"Vaibhav Tripathi"}]},{id:"51930",title:"Gold-Catalysed Reactions",slug:"gold-catalysed-reactions",totalDownloads:1949,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"In recent years, there have been three significant pieces of research which helped propel gold catalysis research into the forefront: the discoveries that gold/silica can catalyse the hydrogenation of pentene, that gold on carbon can be used in the hydrochlorination of acetylene and that deposition-precipitation (DP) methods can be used to prepare nanogold on titania capable of enabling the oxidation of CO at very low temperatures. The synthesis of small gold particles, their characterisation and peculiar properties are considered together with their behaviour as heterogeneous catalysts for a variety of reactions. Some of the issues concerning the practical application of gold catalysts are also discussed.",book:{id:"5310",slug:"catalytic-application-of-nano-gold-catalysts",title:"Catalytic Application of Nano-Gold Catalysts",fullTitle:"Catalytic Application of Nano-Gold Catalysts"},signatures:"J.A. Moma, T.A. Ntho and Michael Scurrell",authors:[{id:"179872",title:"Prof.",name:"Mike",middleName:null,surname:"Scurrell",slug:"mike-scurrell",fullName:"Mike Scurrell"},{id:"183973",title:"Dr.",name:"John",middleName:null,surname:"Moma",slug:"john-moma",fullName:"John Moma"},{id:"183974",title:"Dr.",name:"Thabang",middleName:"Abraham",surname:"Ntho",slug:"thabang-ntho",fullName:"Thabang Ntho"}]},{id:"52066",title:"Supported Gold Nanoparticles as Promising Catalysts",slug:"supported-gold-nanoparticles-as-promising-catalysts",totalDownloads:3108,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"In recent times, gold nanoparticles (AuNPs) either in the form of colloids or as supported nanoparticles are being extensively used as efficient redox catalyst materials. Catalysis particularly using supported gold nanoparticles (AuNPs) has attracted immense research interest due to their unique properties and greater potentiality that is directly related to their particle size. The primary objective of this chapter is to provide comprehensive overview about gold metal nanoparticles (AuNPs) and their application as promising catalysts. This chapter contains six sections in total. Section 1 starts with a general introduction, recent progress, and brief summary of the application of supported AuNPs as promising catalysts for different applications. Section 2 briefs the properties and stability of gold nanoparticles. Section 3 reviews the preparation methods of supported AuNPs for a wide range of catalytic applications. Section 4 describes briefly some of the most commonly reported supported AuNPs for different applications. Section 5 concentrates on our own results related to the application of supported AuNPs in heterogeneous catalysis. In this section, the oxidation of cyclohexane (CH) and benzyl alcohol (BA) to adipic acid (AA), benzaldehyde (BAl), and ammoxidation of 2-methylpyrazine to 2-cyanopyrazine are discussed. Finally, Section 6 describes, main points and outlook are summarized.",book:{id:"5310",slug:"catalytic-application-of-nano-gold-catalysts",title:"Catalytic Application of Nano-Gold Catalysts",fullTitle:"Catalytic Application of Nano-Gold Catalysts"},signatures:"Ahmad Alshammari and Venkata Narayana Kalevaru",authors:[{id:"178547",title:"Dr.",name:"Ahmad",middleName:null,surname:"Alshammari",slug:"ahmad-alshammari",fullName:"Ahmad Alshammari"},{id:"180753",title:"Dr.",name:"V. Narayana",middleName:null,surname:"Kalevaru",slug:"v.-narayana-kalevaru",fullName:"V. Narayana Kalevaru"}]},{id:"50852",title:"Synthesis of Gold Nanoparticles Using Amino Acids by Light Irradiation",slug:"synthesis-of-gold-nanoparticles-using-amino-acids-by-light-irradiation",totalDownloads:3621,totalCrossrefCites:3,totalDimensionsCites:10,abstract:"The synthesis of nanoparticles is generally carried out by chemical reduction, which is effective but uses a number of toxic substances, making the process potentially harmful to the environment. Thus, as part of the search for environmentally friendly or green synthetic methods, this chapter aimed to present the synthesis of gold nanoparticles (AuNPs) using only HAuCl4, Milli-Q water, white light from a xenon lamp, and amino acids. A total of 21 amino acids were studied, and the shapes and sizes of the resultant nanoparticles were evaluated. The products were characterized by ultraviolet-visible (UV-Vis) and fluorescence spectroscopy, zeta potential measurements, and transmission electron microscopy. The synthesis of the AuNPs was successful with 18 amino acids, and the best results were obtained with aspartic acid, arginine, threonine, tryptophan, and valine. The nanoparticles were spherical and their sizes ranged from 5 to 100 nm. Changes in pH were required to improve the stability of the colloidal suspensions.",book:{id:"5310",slug:"catalytic-application-of-nano-gold-catalysts",title:"Catalytic Application of Nano-Gold Catalysts",fullTitle:"Catalytic Application of Nano-Gold Catalysts"},signatures:"Lilia Coronato Courrol and Ricardo Almeida de Matos",authors:[{id:"183894",title:"Ph.D.",name:"Lilia",middleName:null,surname:"Courrol",slug:"lilia-courrol",fullName:"Lilia Courrol"},{id:"185446",title:"MSc.",name:"Ricardo",middleName:null,surname:"Matos",slug:"ricardo-matos",fullName:"Ricardo Matos"}]}],onlineFirstChaptersFilter:{topicId:"44",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. 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We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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