Palliative care in gynaecologic oncology focuses on specific and severe symptoms resulting from affected abdominal and pelvic organs and feminine genitals. These symptoms are mainly connected to advanced gynaecologic malignancies. Patients with locally advanced or recurrent gynaecologic cancers may present with various symptoms. Among those we discuss vaginal bleeding, vaginal discharge and fistulas. Vice versa non-malignant diseases and non-pelvic site diseases such as inflammations, overdose of anticoagulants, wounds or pressure ulcers may have similar clinical manifestation. Some symptoms may result from aggressive cancer treatment (oncological surgery, radiotherapy) with curative intent. Some symptoms get worse on account of the postmenopausal status (natural or artificial following any type of ovarian failure). For advanced gynae-oncological diseases it has been in practise, that the best palliative care is offered and practised simultaneously with curative treatment. The problematics of gynaecologic symptoms in palliative care represents delicate and intimate sphere and it may disturb patient’s autonomy and dignity. The mission of physicians, nurses and caregivers is to consider treatment options thoroughly in context of patient’s quality of life, prognosis and life conditions to fulfil the ideals of the best symptomatic and supportive care.