In Africa, women play an indispensable role in family life. The normative roles of women extend from reproductive role to the raising of children and caring for sick family members. These roles are very unique and are dictated by culture, religion and beliefs. Despite these, their contributions in caregiving remain unrecognized except by the beneficiaries. Caregivers of people living with HIV/AIDS (PLWHA) experience high level of burden due to the expanded role and inadequate preparation for the caregiver’s duty. A descriptive cross-sectional research design was utilized to elicit data from 260 participants in Calabar municipality, Nigeria. Caring for PLWHA is an exceptional service due to exacerbation of symptoms and co-morbidities peculiar to terminal phase of HIV. The study revealed gender inequalities in burden levels. Significant relationships (p < 0.05) also existed between burden of care, availability of support and duration of care during this study. Despite the perceived consequences, the family care givers were still determined to continue caregiving role. This informs the need for governmental support to ameliorate the negative consequences of caregiving by female caregivers.