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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6995",leadTitle:null,fullTitle:"Microencapsulation - Processes, Technologies and Industrial Applications",title:"Microencapsulation",subtitle:"Processes, Technologies and Industrial Applications",reviewType:"peer-reviewed",abstract:"This book is intended to provide an overview and review of the latest developments in microencapsulation processes and technologies for various fields of applications. The general theme and purpose are to provide the reader with a current and general overview of the existing microencapsulation systems and to emphasize various methods of preparation, characterization, evaluation, and potential applications in various fields such as medicine, food, agricultural, and composites. The book targets readers, including researchers in materials science processing and/or formulation and microencapsulation science, engineers in the area of microcapsule development, and students in colleges and universities.",isbn:"978-1-83881-870-8",printIsbn:"978-1-83881-869-2",pdfIsbn:"978-1-83881-871-5",doi:"10.5772/intechopen.73747",price:119,priceEur:129,priceUsd:155,slug:"microencapsulation-processes-technologies-and-industrial-applications",numberOfPages:140,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"09376930370a8a1e60c1ae491a2d7d8d",bookSignature:"Fabien Salaün",publishedDate:"October 2nd 2019",coverURL:"https://cdn.intechopen.com/books/images_new/6995.jpg",numberOfDownloads:8155,numberOfWosCitations:27,numberOfCrossrefCitations:19,numberOfCrossrefCitationsByBook:4,numberOfDimensionsCitations:48,numberOfDimensionsCitationsByBook:4,hasAltmetrics:1,numberOfTotalCitations:94,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 3rd 2018",dateEndSecondStepPublish:"August 29th 2018",dateEndThirdStepPublish:"October 28th 2018",dateEndFourthStepPublish:"January 16th 2019",dateEndFifthStepPublish:"March 17th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"27644",title:"Prof.",name:"Fabien",middleName:null,surname:"Salaün",slug:"fabien-salaun",fullName:"Fabien Salaün",profilePictureURL:"https://mts.intechopen.com/storage/users/27644/images/system/27644.jpg",biography:"Fabien Salaün is a full professor at ENSAIT/GEMTEX, France. His research interests focus on polymer synthesis, encapsulation, and functional coatings for textile applications. He received his Ph.D. from Lille 1 University in 2004 and he was promoted professor in 2014. \r\nHis research interests include polymeric functional materials, smart coating, microencapsulation, thermal comfort, fiber processing, and textile surface functionalization. He has more than 70 publications to his credit, including research papers, reviews and book chapters.",institutionString:"ENSAIT Ecole Nationale Supérieure des Arts et Industries Textilesdisabled",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"154",title:"Biomaterials",slug:"biomaterials"}],chapters:[{id:"64770",title:"Encapsulating Wall Materials for Micro-/Nanocapsules",doi:"10.5772/intechopen.82014",slug:"encapsulating-wall-materials-for-micro-nanocapsules",totalDownloads:1003,totalCrossrefCites:5,totalDimensionsCites:8,hasAltmetrics:0,abstract:"Wall materials play a vital role in the development of micro-/nanocapsules to protect the bioactive compounds against external factors. The encapsulation process and the type of polymers exert a direct impact on the development of bioactive micro-/nanocapsules, which greatly reflect in encapsulation efficiency, solubility, stability, surface permeability, and release profile of desired bioactive compounds. Among the polymers, biodegradable polymeric materials have been the focus for various applications in food, pharmaceutical, and cosmetic industries. Thus, this chapter focuses on different encapsulation techniques and the importance of biodegradable polymers employed as wall materials for developing stable and safe micro-/nanocapsules. Among the natural polymers, protein- and polysaccharide-based polymers are widely used. Similarly, the most commonly used synthetic polymers are polycaprolactone, poly(lactic-co-glycolic acid), and polyethylene glycol. Synthetic polymers have been classified based on their exogenous and endogenous responsive natures. At the end, we have also discussed on the applications of biodegradable polymers employed in the development of micro-/nanocapsules. To compile this chapter and to provide adequate information to the readers, we have explored various sources, such as reviews, research articles, books, and book chapters including Google sites.",signatures:"Shaluah Vijeth, Geetha B. Heggannavar and Mahadevappa Y. Kariduraganavar",downloadPdfUrl:"/chapter/pdf-download/64770",previewPdfUrl:"/chapter/pdf-preview/64770",authors:[{id:"268327",title:"Prof.",name:"Mahadevappa",surname:"Kariduraganavar",slug:"mahadevappa-kariduraganavar",fullName:"Mahadevappa Kariduraganavar"},{id:"277840",title:"Dr.",name:"Shaluah",surname:"Vijeth",slug:"shaluah-vijeth",fullName:"Shaluah Vijeth"},{id:"277843",title:"MSc.",name:"Geetha",surname:"Heggannavar",slug:"geetha-heggannavar",fullName:"Geetha Heggannavar"}],corrections:null},{id:"66276",title:"Microencapsulated Vegetable Oil Powder",doi:"10.5772/intechopen.85351",slug:"microencapsulated-vegetable-oil-powder",totalDownloads:1512,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Vegetable oil has been increasingly popular among consumption oils as it provides several health benefits such as antioxidant, anti-inflammatory, antivasoconstrictive, antiarrhythmic, antithrombotic, antimicrobial, antihypertension, antiaging, etc. Several applications of vegetable oils in foods, cosmetics, and pharmaceutical industries have been widely researched as it is made from natural products with a safe and reliable process. However, oxidative deterioration and stabilization of vegetable oil provide short shelf life storage with poor consumer acceptance. Thus, this chapter is aimed to give an overview of stabilization of vegetable oils using microencapsulation techniques mostly focusing on emulsion preparation using multilayer emulsion followed by a spray drying technique to obtain vegetable oil powder. Using different wall materials was discussed along with the application for several vegetable oils. Moreover, the characterization of encapsulated vegetable oil powder was summarized for the final product quality and encapsulated process efficiency.",signatures:"Ekasit Onsaard and Wiriya Onsaard",downloadPdfUrl:"/chapter/pdf-download/66276",previewPdfUrl:"/chapter/pdf-preview/66276",authors:[{id:"267033",title:"Dr.",name:"Ekasit",surname:"Onsaard",slug:"ekasit-onsaard",fullName:"Ekasit Onsaard"},{id:"270554",title:"Dr.",name:"Wiriya",surname:"Onsaard",slug:"wiriya-onsaard",fullName:"Wiriya Onsaard"}],corrections:null},{id:"65530",title:"Encapsulation of Natural Bioactive Compounds: Nanoemulsion Formulation to Enhance Essential Oils Activities",doi:"10.5772/intechopen.84183",slug:"encapsulation-of-natural-bioactive-compounds-nanoemulsion-formulation-to-enhance-essential-oils-acti",totalDownloads:981,totalCrossrefCites:2,totalDimensionsCites:11,hasAltmetrics:0,abstract:"The microencapsulation technology consists of a trap of a compound inside a tiny sphere known as microsphere. The microencapsulation concerns many different active materials such as bioactive compounds, drugs, vitamins, enzymes, flavors, and pesticides. This technology has gained real interest in numerous fields such as agriculture, cosmetic, pharmaceutical, textile, and food. This chapter highlights the encapsulation of essential oils into nanoemulsion-based delivery system as a model for the encapsulation of natural bioactive compounds. Moreover, an investigation of different parameters affecting the stability of produced nanoemulsion was conducted, in addition to the study of the effect of the nanoencapsulation of essential oils on their antibacterial activity. Finally, an enumeration of the advantages of encapsulating essential oils into nanoemulsion-based delivery systems in order to provide a natural food preservatives has been provided.",signatures:"Mariem Ben Jemaa, Hanen Falleh and Riadh Ksouri",downloadPdfUrl:"/chapter/pdf-download/65530",previewPdfUrl:"/chapter/pdf-preview/65530",authors:[{id:"245237",title:"Dr.",name:"Mariem",surname:"Ben Jemaa",slug:"mariem-ben-jemaa",fullName:"Mariem Ben Jemaa"},{id:"286163",title:"Dr.",name:"Hanen",surname:"Falleh",slug:"hanen-falleh",fullName:"Hanen Falleh"},{id:"286164",title:"Prof.",name:"Riadh",surname:"Ksouri",slug:"riadh-ksouri",fullName:"Riadh Ksouri"}],corrections:null},{id:"64892",title:"Microencapsulation Techniques of Herbal Compounds for Raw Materials in Food Industry, Cosmetics and Pharmaceuticals",doi:"10.5772/intechopen.82415",slug:"microencapsulation-techniques-of-herbal-compounds-for-raw-materials-in-food-industry-cosmetics-and-p",totalDownloads:896,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Microencapsulation is a technique or process of wrapping very small gas particles, gases, or active solid content with a coating material/membrane to protect the active particles (core) from environmental influences like unwanted effects such as light, moisture, and oxygen to increase shelf life of the product. Microencapsulation proposes to protect sensitive food components, reduce nutritional losses, expand the usefulness of sensitive food components, add certain food to other food, protect flavors and fragrances, convert liquid food components to more convenient solids handled, and protect materials from environmental influences. Product microcapsulation can be used as raw material for the food industry, cosmetics, and pharmaceuticals using bioactive compounds. From the results of the curcuminoid content testings, it can be observed that an increase of drying temperature produces lower amount of curcuminoid contents, which is caused by the inability of curcuminoid compounds to be preserved by maltodextrin, as the microencapsulant. The best temperature to preserve curcuminoid compounds is at 110°C, in which 10.52% is preserved. Hence, for Aloe vera processing, the optimum drying temperature was 120°C which maintained the active component of Aloe vera powder such as Aloenin (B), Aloeresin A, and Chrysophanol.",signatures:"Tri Yuni Hendrawati, Alvika Meta Sari, Muhamad Iqbal Syauqi Rahman, Ratri Ariatmi Nugrahani and Agung Siswahyu",downloadPdfUrl:"/chapter/pdf-download/64892",previewPdfUrl:"/chapter/pdf-preview/64892",authors:[{id:"266094",title:"Dr.",name:"Tri Yuni",surname:"Hendrawati",slug:"tri-yuni-hendrawati",fullName:"Tri Yuni Hendrawati"},{id:"266723",title:"MSc.",name:"Alvika Meta",surname:"Sari",slug:"alvika-meta-sari",fullName:"Alvika Meta Sari"},{id:"276806",title:"Dr.",name:"Ratri Ariatmi",surname:"Nugrahani",slug:"ratri-ariatmi-nugrahani",fullName:"Ratri Ariatmi Nugrahani"},{id:"276807",title:"BSc.",name:"Muhamad Iqbal",surname:"Syauqi Rahman",slug:"muhamad-iqbal-syauqi-rahman",fullName:"Muhamad Iqbal Syauqi Rahman"}],corrections:null},{id:"65645",title:"Applications of Microcapsules in Self-Healing Polymeric Materials",doi:"10.5772/intechopen.83475",slug:"applications-of-microcapsules-in-self-healing-polymeric-materials",totalDownloads:1355,totalCrossrefCites:3,totalDimensionsCites:11,hasAltmetrics:0,abstract:"Self-healing polymeric materials have a great potential to be explored and utilized in many applications such as engineering and surface coating. Various smart materials with self-healing ability and unique self-healing mechanisms have been reported in recent publications. Currently, the most widely employed technique is by embedding microcapsules that contain a healing agent into the bulk polymer matrix. When cracks develop in the polymer matrix, the curing agent is released from the microcapsules to cross-link and repair the cracks. Microencapsulation of the healing agent in the core can be achieved by in situ polymerizing of shell material. This chapter presents a general review on self-healing materials, and particularly, self-healing of epoxy matrices that includes epoxy composite and epoxy coating by microencapsulation technique. Microencapsulation processes, including types of resin used, processing parameters such as core/shell ratio, concentration of emulsifiers, viscosities of aqueous and organic phases and stirring rate are discussed.",signatures:"Seng Neon Gan and Nurshafiza Shahabudin",downloadPdfUrl:"/chapter/pdf-download/65645",previewPdfUrl:"/chapter/pdf-preview/65645",authors:[{id:"105214",title:"Prof.",name:"Seng-Neon",surname:"Gan",slug:"seng-neon-gan",fullName:"Seng-Neon Gan"},{id:"277051",title:"Dr.",name:"Nurshafiza",surname:"Shahabudin",slug:"nurshafiza-shahabudin",fullName:"Nurshafiza Shahabudin"}],corrections:null},{id:"67432",title:"Microencapsulation and Its Uses in Food Science and Technology: A Review",doi:"10.5772/intechopen.81997",slug:"microencapsulation-and-its-uses-in-food-science-and-technology-a-review",totalDownloads:1890,totalCrossrefCites:7,totalDimensionsCites:13,hasAltmetrics:1,abstract:"Microencapsulation is a group of technologies aiming to produce small particles called microcapsules that can be released at a specific speed under certain conditions. Microencapsulation technology is used in the pharmaceutical, agrochemical, and food industries; however, microcapsule production is most challenging for applications in the food industry owing to the high costs of the technique, which may make the final product too expensive. Common methods for microencapsulation include spray-drying and coacervation, and different wall materials and filling materials can be used for both techniques. In this review, we summarize current methodologies used for microencapsulation, with a focus on applications in the food industry.",signatures:"Pedro Henrique Rodrigues do Amaral, Patrícia Lopes Andrade and Leilane Costa de Conto",downloadPdfUrl:"/chapter/pdf-download/67432",previewPdfUrl:"/chapter/pdf-preview/67432",authors:[{id:"268220",title:"Dr.",name:"Leilane Costa De",surname:"Conto",slug:"leilane-costa-de-conto",fullName:"Leilane Costa De Conto"},{id:"274532",title:"Mr.",name:"Pedro Henrique Rodrigues Do",surname:"Amaral",slug:"pedro-henrique-rodrigues-do-amaral",fullName:"Pedro Henrique Rodrigues Do Amaral"},{id:"274534",title:"Dr.",name:"Patrícia Lopes",surname:"Andrade",slug:"patricia-lopes-andrade",fullName:"Patrícia Lopes Andrade"}],corrections:null},{id:"65481",title:"Lag, Constant and Decay Release Characteristic of St-PVOH Encapsulated Urea as a Function of Coating Thickness Using Different Empirical Models",doi:"10.5772/intechopen.83729",slug:"lag-constant-and-decay-release-characteristic-of-st-pvoh-encapsulated-urea-as-a-function-of-coating-",totalDownloads:518,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Uncoated urea, when applied to crops is susceptible to losses from volatilization, leaching, nitrous emission and water eutrophication. Plants require varying quantities of nutrients during different stages of growth; they need smaller amounts during infancy and larger amounts during the development of roots, stalk and stem. In this research, controlled release coated urea (CRCU) was synthesized via encapsulation with starch- polyvinyl alcohol biocomposite (St-PVOH). Lag, constant and decay release characteristic of the CRCU were simulated using different empirical models as a function of coating thickness. Structural elucidation and morphology of the raw urea and CRCU were determined using FTIR and SEM analytical techniques, respectively. FTIR confirm esterification reaction for St-PVOH. The SEM image of the raw urea appears rough and have fine openings while that of CRCU possesses a seemingly decrease in membrane porosity, ordered and uniform layer. This characteristic qualifies the CRCU as a semi-permeable membrane. Simulation results revealed that coating thickness of 4.3 and 6.4 are best desirable in designing a CRCU for plant at infancy stage, root, and stalk and stem development. Overall, sigmoidal law shows best robust prediction to expanded varying coating thicknesses.",signatures:"Chigozie Francolins Uzoh and Stone Raphael Odera",downloadPdfUrl:"/chapter/pdf-download/65481",previewPdfUrl:"/chapter/pdf-preview/65481",authors:[{id:"269423",title:"Dr.",name:"Chigozie",surname:"Uzoh",slug:"chigozie-uzoh",fullName:"Chigozie Uzoh"},{id:"292536",title:"Dr.",name:"Raphael",surname:"Stone Odera",slug:"raphael-stone-odera",fullName:"Raphael Stone Odera"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6280",title:"Biomaterials",subtitle:"Physics and Chemistry - New Edition",isOpenForSubmission:!1,hash:"4d45002a20a9496ff80f5c0166d9be33",slug:"biomaterials-physics-and-chemistry-new-edition",bookSignature:"Rosario Pignatello and Teresa Musumeci",coverURL:"https://cdn.intechopen.com/books/images_new/6280.jpg",editedByType:"Edited by",editors:[{id:"64447",title:"Prof.",name:"Rosario",surname:"Pignatello",slug:"rosario-pignatello",fullName:"Rosario Pignatello"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9574",title:"Biomaterials",subtitle:null,isOpenForSubmission:!1,hash:"730b237f28a94ddad58ba55ee6ab8811",slug:"biomaterials",bookSignature:"Petrică Vizureanu and Claudia Manuela Da Cunha Ferreira Botelho",coverURL:"https://cdn.intechopen.com/books/images_new/9574.jpg",editedByType:"Edited by",editors:[{id:"12354",title:"Prof.",name:"Petrică",surname:"Vizureanu",slug:"petrica-vizureanu",fullName:"Petrică Vizureanu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Cerebral circulation comprising of both arterial (Figure 1) and venous system (Figure 2), is a complex three-dimensional (3D) anatomical structure. Various textbooks and chapters have thrown light on the cerebral circulation system with multiple images and various sections of it. Despite that, neophytes may still find it difficult to mentally visualize the complex structures by cognitive 3D mapping. Hence, we have created a 3D model of the cerebral circulatory system and have provided it, both on an augmented reality (AR) platform as well as 3D printed models, to aid in the visual and tactile guide while learning and teaching.
Image showing the circle of Willis and its parts.
Image showing the cerebral venous system and its parts.
AR and 3D printed models help in academic-oriented learning of all the cerebral circulation disease conditions and their pathophysiologies [1, 2, 3, 4]. We have created 3D models of the cerebral system comprising of various parts such as the cerebral nervous, venous and arterial system along with the brain, brainstem, and eyeball in fine detail (Figure 3). By creating these models with meticulous detailing and by incorporating them through AR (Figures 4–6), and by 3D printing these models (Figures 7–9), understanding of the disease process is made more serene and undemanding with gameful cognitive learning. Also, complex pathways such as the cranial nerve pathways (Figure 10) are traced in a three-dimensional manner for facilitating easy cognitive reading.
Image showing the 3D model of the cerebral system comprising of various parts such as the cerebral nervous, venous and arterial system along with the eyeball and its components.
Image showing the circle of Willis in the mobile screen over the AR template (red arrow).
Image showing the cerebral venous system in the mobile screen over the AR template.
Image showing the eyeball in the mobile screen over the AR template.
(a) Image showing the 3D printed puzzle pieces of the circle of Willis. (b) Image showing the final assembled model of the circle of Willis, after the puzzle pieces are joined together.
(a) Image showing the 3D printed puzzle pieces of the cerebral venous system. (b) Image showing the final assembled model of the cerebral venous system, after the puzzle pieces are joined together.
(a) Image showing the 3D printed puzzle pieces of the eyeball. (b) Image showing the final assembled model of the eyeball, after the puzzle pieces are joined together.
(a) Image showing the various cranial nervous systems highlighting the (b) 3rd cranial nerve, (c) 4th cranial nerve, (d) 5th cranial nerve, (e) 6th cranial nerve, (f) 7th cranial nerve and (g) 8th cranial nerve respectively in green colour.
Ophthalmologist may be the first responder for detecting the cerebral pathologies earlier, thus helping in faster diagnosis and aiding in speedy treatment. In this chapter, we have discussed the anatomy of various ophthalmology-related cerebral arterial systems from a neophyte’s point of view in detail, with the help of innovative 3D models and animative video created by us, to simplify the concept learning to aid in timely diagnosis and effective management.
The circle of Willis (Figure 1) is a ring of vessels that provides important colligative communications between the anterior and posterior circulations of the midbrain and hindbrain. The communications are established between the carotid and vertebrobasilar systems in conjunction around the optic chiasma and infundibulum of the pituitary stalk in the suprasellar cistern. It is named after Thomas Willis (1621–1675), an English physician [5]. The circle of Willis plays an important role, as it allows proper blood flow from the arteries to both the anterior and posterior hemispheres of the brain, and defends against ischemia in the incident of vessel disease or damage in one or more areas. In the event of arterial incompetency, it also provides collateral arterial flow to the affected brain regions [6, 7, 8].
Vessels comprising the circle of Willis include the following:
Anterior circulation
Posterior circulation
Video 1. Animated video depicting the anatomical structures of circle of Willis. Available from (can be viewed at): https://www.youtube.com/watch?v=yCM0Tq9JiFY
When the right and left internal carotid artery (ICA) enter the cranial cavity, each one divides into two main branches:
Anterior cerebral artery (ACA)
Middle cerebral artery (MCA)
The ring is formed proximally by a single anterior communicating artery (AComA), which links the bilateral ACAs. Each ICA individually gives off an ophthalmic artery. At the junction between the ACA and the ICA, the lateral continuation of the ICA becomes the MCA.
The posterior communicating artery (PComA) arises from each ACA-ICA junction. The PComA connects the MCA with the posterior cerebral artery (PCA), to form the posteriormost aspect of the circle of Willis. The basilar artery (BA) forms from the fusion of the bilateral PCAs. The BA provides many branches, including the superior cerebellar arteries, pontine arteries, and the anterior inferior cerebellar artery (AICA). From the BA emerges bilateral vertebral artery (VA), which each gives of a posterior inferior cerebellar artery (PICA). The BA artery also contributes to the formation of a single anterior spinal artery [9, 10]. The combination of the AComA and the PComA makes up the circle of Willis, which permits collateral flow between the carotid and vertebrobasilar systems when there is vascular compromise.
The ICAs are part of the anterior circulation, which carries major blood supplies to the intracranial contents. There is a total of two ICA; originating from the carotid bifurcation, which runs cephalically through the neck and into the brain. It enters the skull through the carotid canal and reaches the cavernous sinus through the foramen lacerum after passing the parasellar area, and gives off the meningohypophyseal trunk that supplies the dura at the back of the cavernous sinus, as well as the oculomotor, trochlear, trigeminal, and abducens cranial nerves. The ICA makes a loop to reverse its direction under the anterior clinoid and the optic nerve at the anterior aspect of the cavernous sinus and passes through the two dural rings. After passing through the second dural ring, it becomes intradural and gives off the ophthalmic artery which is stemming out from the ophthalmic segment (C6) of the ICA. The ophthalmic artery enters into the orbit through the optic canal. It provides numerous collateral branches to supply the optic nerve. The ophthalmic artery’s first major daughter branch is the central retinal artery which supplies the retina [11]. The ophthalmic artery provides oxygenated blood to the extraocular muscles, some facial muscles, as well as the intrinsic muscles of the eye [12]. Distal to the origin of the ophthalmic artery, the intradural supraclinoid ICA gives rise to the anterior choroidal artery which supplies blood to the lateral geniculate body (LGB) distally and the optic tract proximally. Anterior choroidal artery anastomoses with the PCA through the PComA. The ICA gives off the ACA and ends as a branch of the MCA [13].
The AComA connects the two ACAs across the starting point of the longitudinal fissure, organizing the anterior border of the cerebral arterial circle of Willis. Besides forming the conjugation channel between the anterior cerebral arteries, the AComA also contributes to supplying blood to certain parts of the brain via its anteromedial central branches. This artery supplies parts of the optic chiasma and intracranial optic nerves [14].
The two ACAs are connected by the AComA. The ACA develops from a primitive anterior division of the ICA that initially supplies oxygenated blood to most midline portions of the frontal lobes, and superior, medial, and parietal lobes. The basal branch arising from the lenticulostriate branch of ACA supplies the posterior aspect of the optic chiasma. The cortical branch and orbitofrontal branch of ACA supply the olfactory cortex, gyrus rectus, and medial orbital gyrus [15].
The right and left PComAs form the dorsal part of the circle of Willis, at the base. Each PComA links the three cerebral arteries of the same side. Before the terminal bifurcation of the ICA into the ACA and MCA, the PComA connects to the ICA anteriorly. It links with the PCA posteriorly. The PComA supplies the rear part of the optic chiasma and optic tract [16].
The left and right PCA is a terminal branch that arises from the bifurcation of the BA. The PCA moves around the cerebral peduncle and supplies the occipital lobe, the inferomedial surface of the temporal lobe, midbrain, thalamus, and choroidal plexus of the third and lateral ventricles after passing above the tentorium. The PCA gives off central branches and cortical branches which supplies the subcortical and cortical structures, respectively. The central branches of PCA include the thalamoperforating artery, thalamogeniculate artery, and posterior choroidal artery. The cortical branches of PCA include the temporal artery, occipital artery, parieto-occipital artery, and calcarine artery [17, 18].
The thalamoperforating arteries arise from the P1 segment of PCA and supplies parts of the thalamus, the third ventricles, and the midbrain. The thalamogeniculate artery arises from the P2 segment of PCA and supplies the medial and lateral geniculate bodies and the pulvinar of the thalamus. The medial and lateral posterior choroidal arteries supply the dorsal portion of the thalamus and the choroidal plexus.
The temporal branches are given off from the P2 segment supply the uncus and the parahippocampal, medial, and lateral occipitotemporal gyri. The occipital branches supply the cuneus, lingual gyrus and posterolateral surface of the occipital lobe. The parieto-occipital artery arises from the P3 segment and supplies the cuneus and precuneus. The calcarine artery supplies the visual cortex, inferior cuneus, and part of the lingual gyrus, which arise indirectly from the occipital artery.
The visual cortex responsible for the contralateral field of vision lies in its domain. The macular part of the visual cortex often receives blood supply from both the PCA and MCA. It describes the “macular sparing” phenomenon in some patients following a PCA infarct.
The right VA arises from the innominate artery, and the left VA begins as a branch of the proximal subclavian artery. The VA moves through a series of foramina in the lateral aspect of the cervical vertebral processes. After crossing the dura at the foramen magnum, the VA gives rise to the PICA before linking the other VA to form the BA. Along the course of the BA, small branches arise directly to supply parts of the pons and midbrain. The median branches of the BA supply the medial longitudinal fasciculus, paramedian pontine reticular formation (PPRF), and the medially located nuclei of the oculomotor, trochlear, and abducens nerve. The pontine branch of the BA also supplies the front portions of the cranial nerves (particularly the trigeminal nerve) at the point where they exit from the brainstem. Distally, the PICA supplies the inferior cerebellum, which is closely involved in eye movements. The AICA originates from the caudal BA and supplies the pontomedullary junction and the posterior part of the cerebellum. The internal auditory artery which is a large proximal branch of the AICA supplies the facial cranial nerve complex in the subarachnoid space and follows it into the internal auditory canal [19].
The construction of the cerebral arterial system was done in Maya LT software [3, 20]. The reference image was first taken for the cerebral arterial system to e-trace it using the CV curve tool. Tracing of the different arteries was done using the three orthographic views, namely X-axis, Y-axis and Z-axis (Figure 11). This results in a cerebral arterial system, which is made up of lines and curves (Figure 12a). Next, a circle was extruded along every curve, thereby resulting in a cerebral arterial system made up of tubes (Figure 12b); and these tubes were tweaked in a way, that their ends are narrowed and closed (Figure 12c).
Image showing the traced cerebral arteries using the CV curve tool in the three different orthographic views namely, X-axis (bottom right), Y-axis (top left), and Z-axis (bottom left). The top right block shows us the default perspective view.
(a) Image showing the cerebral arterial system made up of lines and curves. (b) Image showing the cerebral arterial system made up of tubes. (c) Image showing the cerebral arterial system with narrowed and closed ends. (d) Image showing the cerebral arterial system with approximated artery colour given from default colour palette.
The other minor appendages and extensions of the circle of Willis were drawn on a plane, followed by deletion of the unnecessary ones and finally the face of the model was extruded. Extrusion is mainly done to provide thickness, so that the thin line will transform into a vessel of appropriate thickness. The face extruded model was then applied to the retopologize function to clean up and smoothen the model. Finally, the circle of Willis was merged with its appendages through edge bridging and offset correction, resulting in the creation of the ‘cerebral arterial circulation system’ structure.
Similarly, the cerebral venous system, cranial nerves, cerebrum, cerebellum, brain stem (Figure 3) and the eyeball with TrueColor confocal images can be created.
The constructed model was given an approximated artery colour from the default colour palette (Figure 12d). This step can be done in Maya LT software or Blender software [21]. If Blender software is used, the 3D models have to be first exported from Maya LT software and imported into Blender software.
The 3D models can be successfully launched in AR after UV unwrapping and lighting, followed by coding the models for the AR module in Unreal Engine software for a successful run.
The 3D models have to be exported from Maya LT software and imported into Blender software for UV unwrapping. UV unwrapping is the process of cutting out a 3D model and placing it on a 2D plane. UV unwrapping is done so that the model can be lit in the absence of scene lights, which is very essential for a successful AR module.
If there is no light in the AR scene, the 3D models inside the Unreal Engine software will appear black (Figure 13a). If we add light to the AR scene in the Unreal Engine software, the Android mobile phones will not be able to process it. But, processing the model by the mobile phone is of utmost importance, as the AR module innovated by us needs an Android mobile phone platform to operate. Hence, a lightmap has to be generated and applied to the 3D models to view the models correctly (Figure 13b), which cannot be done in Unreal Engine software. Hence, these lightmaps have to be generated in Blender software and then imported into the Unreal Engine.
(a) Image showing the cerebral arterial system is appearing as black due to the absence of lightmap. (b) Image showing the cerebral arterial system is appearing in normal colour due to presence of lightmap.
The Unreal Engine is an integrated development environment (IDE) used to develop applications for various platforms [22, 23, 24]. The AR application is one such application that was coded in the Unreal Engine software [25]. The 3D models were exported from Blender software after UV unwrapping and imported into the Unreal Engine level file for the initiation of AR. Finally, the app (Eye MG AR) is built from the Unreal Engine for Android devices. The link for the app is given below:
A dataset array is set up in Unreal Engine software which contains the image of the AR template (Figure 4). When the program starts running, all the images in the camera view will be tracked. If any of the tracked images match with the AR template from the data set array, the 3D models will be spawned, with transform values matching the centre of the AR template. If the 3D model is already spawned, then the transform value is updated to the centre of the AR template and will go to the next frame. This is the algorithm for the AR module (Figure 14), and it is made to run on a loop at multiple frames per second (FPS) depending on the device.
Image showing the coding/algorithm of the AR module.
The 3D printing of ophthalmology related models has been proposed first by Ramesh et al. for enhancing learning through the concept of puzzle assembly (Figures 7-9) [26]. The concept of puzzle assembly can serve as a comprehensive self-learning tactile tool kit for neophytes [26, 27, 28, 29, 30, 31]. 3D printing models can overcome the limitations of the theoretical framework of textbooks used for studying [32, 33, 34, 35]. Practical sessions facilitate teaching and 3D printing anatomical puzzle models perfectly augment it cost-effectively.
The software used to create the 3D models was Maya LT. Cura software was used for printing the models in sliced layers. Cura software gives the output in an STL format, which is the standard tessellation language format for 3D printing FabX XL printer was used to print the Circle of Willis model and the eye. FabX Plus printer was used to print cerebral venous system model. Polylactic acid (PLA) material which is a biodegradable plastic, manufactured from corn starch, cassava and sugar cane waste was used for 3D printing all anatomical structures except the retina. For the retina, thermoplastic polyurethane (TPU) material was used for 3D printing.
The 3D models created by us are currently available for free download from the website (mcmi.in).
The PLA plastic costs approximately 13.43 USD for 1 kg weight. TPU costs approximately 40.28 USD for 1 kg weight.
The economics involved in 3D printing models is as follows:
Circle of Willis model costs approximately 6.71 USD for 400 g sample
Cerebral venous system model costs approximately 6.71 USD for 400 g sample
Eyeball model costs approximately 26.85 USD for 1 kg sample
The duration of printing the 3D models is as follows:
10 hours to print: The circle of Willis
5 hours to print: The cerebral venous system
48 hours to print: The eyeball
Cerebral arterial circulation and other allied anatomical structures are best understood with sound knowledge of their complex anatomy. In this chapter, we have simplified the anatomical learning of these complex anatomical structures with 3D AR models (in the free Android app Eye MG AR) and 3D printed models for better concept learning. This cognitive learning module of the cerebral circulation will aid in concept building for neophyte ophthalmologists, neurosurgeons, intensivists, physicians, and paramedics thus aiding in faster diagnosis, speedy treatment and effective rehabilitation.
We are grateful to Mr. Pragash Michael Raj (Department of Multimedia), and Mrs. Priyadharshini of Mahathma Eye Hospital Private Limited, Trichy, Tamil Nadu, India for their technical support throughout the making of this chapter and its illustrations. We sincerely express our thanks to Ms. Banasmita Mohanty for her support for the proofreading of this chapter. We are also grateful to Dr. Sabin Malik for his support and help with references for the anatomy of the cerebral models used for animation in this chapter.
The authors declare no conflict of interest.
I (Dr. Prasanna Venkatesh Ramesh) owe a deep sense of gratitude to my daughters (Pranu and Hasanna) and family (in-laws) for all their prayers, support, and encouragement. Above all, I extend my heartfelt gratitude to all the patients who consented to the images which are utilized for this chapter.
I (Dr. Shruthy Vaishali Ramesh) want to thank my partner (Arul) for his constant support and encouragement during the process of creating this chapter.
In the form, the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the chapter. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
3D models were created and used in animations by us in this chapter. This includes the human eyeball with TrueColor confocal fundus image, cranial nervous system, the cerebral venous system, cerebral arterial system (comprising of the circle of Willis), brain stem nuclei, extraocular muscle, meninges etc. These models help in better understanding and can be used in various fields of medicine. We have created models which are related to ophthalmology, which allows us to explain a disease or a condition with its pathophysiology, pathway, clinical features, tests, treatment and prognosis.
These models can be 3D printed, used for augmented reality simulations, used for virtual reality and can also be used for advanced mixed reality with Microsoft HoloLens. 3D models when used for real-time teaching, especially with the help of multimodal fundus images, microscopic structures like the trabecular meshwork, angles, diseases of lens etc., can pave the way for new-age pedagogy. We have created apps using these models like the Eye MG AR (https://play.google.com/store/apps/details?id=com.EyeMG_AR) and Eye MG 3D (https://play.google.com/store/apps/details?id=com.EyeMG_3D) which are based on augmented reality model of the eye and multimodal fundus imaging atlas, respectively. These are available for Android users and are free to download from Google Play Store. An app for iPhone users, named Eye MG Max is currently available in App Store. In this application, eyeball with TrueColor confocal fundus images, and all structures related to ophthalmology are provided with a user-friendly interface. In Eye MG Max, multiple views with transparency for viewing the structures passing through another model, free camera mode, annotated modes, customised zoomed views and videos related to any ophthalmic pathology are provided; thus, providing a 3D atlas at the user’s fingertip for comprehensive learning.
three-dimensional anterior cerebral artery anterior communicating artery anterior inferior cerebral artery basilar artery cranial nerve external carotid artery frames per second internal carotid artery integrated development environment lateral geniculate body medial cerebral artery medial longitudinal fasciculus posterior cerebral artery posterior communicating artery posterior inferior cerebellar artery polylactic acid paramedian pontine reticular formation thermoplastic polyurethane vertebral artery
In global terms, yield losses due to arthropods, diseases, and weeds are estimated to an approximately 35% of the total agricultural products. Yield losses in developing regions with limited pest management options may exceed up to 50% [1]. There are many adverse interactions between insects and plants, like insects, pests, and pathogens, leading to total or complete crop failure [2]. Crop protection has played a crucial role in ensuring food security, preserving crop productivity, and rising yields. More recently, the use of integrated pest management for pest control has become more prevalent in developed countries, but the continued use of pesticides to manage pest epidemics remains prominent [1, 3]. Increased use of synthetic pesticides is observed in the developed and transitional countries [4]. Many farmers in developing countries lack access to synthetic pesticides [5]. Biological controls and botanical pesticides (in this case, plant products) are frequently unavailable or expensive. They are used in alternative ways, like inter-crop pest control rather than pesticide sprays to eliminate crops [6, 7].
Botanicals were used in agricultural pest control in China two thousand years ago and Greece and India before they became widely accepted [1]. Traditional botanical pest control for crop protection or storage remains widely distributed today among traditional and subsistence farmers [1, 4]. In some areas of Zimbabwe and Uganda, up to 100% of farmers use botanical products [5, 8]. Globally, there have been reports that more than 2500 plant species from 235 families have biological pest control activities [9, 10]. Notably, in many farmer surveys, using various botanical substances to control insect pests is underlined, with 10 botanicals used by farmers worldwide [5, 11].
Given the limited availability of synthetic pesticides and the prohibitive cost for farmers and transitional growers, botanicals are often a viable alternative to synthetic pesticides in the developing and subsistence agriculture sector [1]. Botanical preparations are vigorously promoted in the advisory materials of many government agricultural departments. As a result, plant-wise national extension partners, led by the CABI, sometimes use homemade pesticide products in their guidelines and extension materials (www.plantwise.org).
Different insecticidal activities such as toxicity, feeding deterrence, and repellency against other insect pests are possessed by plant secondary metabolites such as terpenoids, alkaloids, and phenols. The protection of plant species against insect herbicides has been used for many years in botanical insecticides, such as extracts and essential oils. Natural enemies are sometimes killed or injured by synthetic insecticides [1, 5, 12]. Additionally, plant extracts tend to have multiple actions and low toxicity, making them safer for non-target species. However, another significant advantage of botanical is that they tend to depend rather than on one active ingredient on closely related “suites” of active substances. It could either prevent or delay the spread of pest population resistance. Biopesticides have been utilized as a long way to keep pests under control until synthetic pesticides have replaced plant extracts. There is currently only about 1 per cent of the global use of pesticides for botanical insecticides, but that number increases due to greater attention on this class of products [13, 14, 15]. Plant extracts from common weed species are frequently produced in developing countries that are accessible and obtain labour as the only cost. However, Botanical pest management is a less expensive alternative to insecticides [16, 17].
The suitability of botanical recommendation and use can be questioned to control pests. Over the past decades, the evidence for the use of botanicals generally has been deemed consistent, but it must be re-evaluated to assess their effectiveness. Some botanicals used to control pesticides may be without active ingredients, a waste of time for little growers. Moreover, results may be unpredictable because of varying levels of active ingredients, concentrations in the used plant material, and differences in the preparing methods [7]. Despite this, their toxicity to non-targets has not been proven. While there is rising scientific evidence that some plant pesticides are less toxic to non-target species than synthetic pesticides, there is also evidence that some non-target species or ecosystems may be threatened by other botanicals, livestock, or the general environment [14]. Despite their significant prevalence, however, it is impossible to ignore the use of botanicals for pest control. There have been extensive research trials in the use of traditional pesticides and control methods conducted over the last several decades. However, a comprehensive scientific understanding of the use of conventional botanicals for insecticides, including those used by subsistence and transition farmers, is lacking.
Three distinct botanicals were investigated in this chapter to see either they worked against insects or pests, including their scientific proof for their efficacy and reliability was discovered. The findings indicate the potential and limitations as alternatives to pesticides of selected botanical insecticides. The safety and well-being of humans are briefly mentioned, as well as considerations of cost and practicality.
A substance employed to destroy pests that cause damage or obstacle to desired crops, shrubs, trees, timber, and plant growth is called insecticide. Pesticides that usually remain in nature and/end up take a long time in the body or tissue pose significant problems for humans and the environment for a wide range of environmental health and safety. Many pesticides are non-specific, so they can kill or be responsible for the death of either beneficial or destructive organisms [5].
One of the naturally occurring chemicals found in plants is referred to as botanical pesticides. Nature-oriented pesticides can be used as an alternative to synthetic formulations, but they are usually claimed to be more toxic to humans. Some of the most lethal carcinogenic substances, like deadly toxins, develop quickly and thrive in nature [18].
Mode of action is defined as a specific functional or physiological change in a living organism resulting from its exposure to a substance. The affected biological steps, enzymes, or proteins of the living organism are usually included in the mode of action. Most others classify pesticides as controlled, physical, or chemical characteristics; the mode of action primarily refers to how the pesticide interrupts an organism’s biological processes [1, 18].
Scientists must understand the mode of action to increase the quality and long-term viability of a product used in pest management plans. To better understand how pesticides function, it is critical to understand how the targeted system of the pest is working. Understanding how humans and other systems operate also helps us to control pests effectively. It also needs to learn the modes of action of the pesticides, which will help to prevent resistance to the specific pesticide(s) [18].
Sulfur-containing compounds produced by the enzymatic degradation of allicin are thought to be responsible for garlic’s pesticide activity. There have been laboratory trials that have demonstrated that garlic extracts have insecticidal and acaricidal properties. They can also be used as control agents for Coleoptera, Lepidoptera, and Hemiptera insect species [19, 20, 21, 22]. Garlic aqueous extracts were found to control Hemiptera pests, Lepidoptera pests, and mites to varying degrees in field application trials [23, 24, 25, 26]. Other research suggests that homemade pesticides based on garlic could control fruit flies on watermelons and mites on tomatoes [27, 28].
Insects are affected by azadirachtin in two ways. At the physiological stage, azadirachtin prevents the prothoracic gland from producing and releasing molting hormones (ecdysteroids), resulting in immature insects, which causes incomplete ecdysis. A related mechanism of action is responsible for adult female insect sterility. Furthermore, azadirachtin is a powerful antifeedant for a variety of insects. It is thought that Schmutterer [29] was the first to discover the problem of swarming locusts in the desert. Still, neem trees had covered the area before then, so it was only found later that they destroyed all the local vegetation except for imported neem. Because of its exceptionally antifeedant activity in the desert locust, azadirachtin was first isolated and remained the most potent antifouling agent discovered to date. In the United States, neem has quickly become the new model for producing botanical pesticides [1].
The limonoids in neem are thought to be responsible for their insecticidal properties. Although azadirachtin is thought to be the most active compound, other limonoids may enhance its activity and activeness and inhibit resistance buildup [30]. Commercial neem extracts are commonly used to monitor a wide variety of insects and mites. Commercial neem-based products’ insecticidal and acaricidal properties have been extensively demonstrated [18, 30].
Blatt dean, Hemiptera, Lepidoptera, and Thysanoptera pests have been successfully controlled with aqueous extracts produced at home using neem plant content (unformulated oil, seed cake, leaves, and seeds) [23, 31, 32, 33, 34, 35, 36]. In various trials against Lepidoptera pests, aqueous neem extracts were found to be effective. Patil and Nandihalli [37] were the only researchers to demonstrate the effectiveness of aqueous neem extracts in field applications; extracts or an oil emulsion is used to combat mite pests. Both preparations decreased mite population but did not affect yield. It has been confirmed that neem oil is effective against fruit flies targeting watermelon, but no statistics have been given.
Coleopteran pests were controlled successfully and constantly in storage trials through ground neem plant material [27, 37, 38, 39, 40]. The effectiveness of the ground neem is supported by participatory farm studies carried out by Paul et al. [41] and other earlier studies [5, 7, 9].
Biologically active components are difficult to pin down in neem products, as they are found in complex mixtures. Studies show that neem has insecticidal, repulsive, anti-ovipositional, growth-regulating, and toxic properties in various forms of insects. Neem serves as a natural insect repellent, preventing insects from starting to eat. It acts as a feeding deterrent, making insects avoid eating if there is a presence of deterrent factors, as part of the first “taste” ingesting food at some points (might be due to secondary hormonal or physiological effects of the deterrent substance). Neem has been proven to be strong in halting the growth of most insects through the means of disrupting chitin synthesis. Due to species’ susceptibility, the effects of neem can vary widely [41].
Secondary metabolites produced by plants are superior to synthetic or synthetic pesticides as viable alternatives to a primary pest control strategy [42]. Furthermore, insecticide resistance to synthetic pesticides resulted in significant food losses due to chemical failure in pests. As a result, annual economic losses in the billions of dollars occur worldwide [1, 5]. Furthermore, essential oils are also considered safer than synthetic pesticides by the FDA due to non-target neurotoxic, carcinogenic, teratogenic, and mutagenic effects, as well as insect multi- and cross-resistance [43]. Their popularity in organic farmers and the environmentally aware consumer has considerably increased as insecticides in essential oils derived from aromatic plants. They have repellent, antifeedant, inhibitors to oviposition and growth, ovicides, and growth-reducing effects in several insects [42, 43, 44]. Essential oils possess an exciting impact of larvicide on larvae, insecticide activity, abusive ants, cockroaches, bedbugs, moths, fluid headlice, and toxic to termites (Lepidoptera: Lymantriidae, gipsy moth).
The chemistry of volatile elements in essential oils can be categorized into four major groups: benzene derivatives, hydrocarbons, terpene, and other miscellaneous compounds. Monoterpenoids constitute 90% of the essential oil, and they are the most representative molecules that allow for a wide variety of different structures. There are 10 hydrocarbons, or their related compounds, that is, cyclic alcohols (e.g., isopulegol, menthol, terpineol), acyclic alcohols (e.g., geraniol, linalool, citronellol), bicyclic alcohols (e.g., verbenol, borneol), ketones (menthone, carvone, thujone), phenols (e.g., carvacrol, thymol), acids (e.g., chrysanthemum acid), oxides (cineole), and aldehydes (citronellal, citral). Terpenes are the major group, while aromatic and aliphatic constituents are the other minor groups. Terpenes are mostly monoterpenes (C10) as well as sesquiterpenes (C15), but hemiterpenes (C5), diterpenes (C20), triterpenes (C30), and tetraterpenes are also available (C40). Phenylpropane-derived aromatic compounds are less prevalent than terpenes, for example, aldehyde: cinnamaldehyde; methylenedioxy compounds: apiole, myristicin, safrole; phenols: chavicol, eugenol; alcohol: cinnamic alcohol; methoxy derivatives: anethole, elemicin, estragole, methyl eugenols [48].
The oil composition varies widely, mainly depending on the way that was used to isolate it. Essential oils have a different chemical composition, depending on the type of molecules extracted and the number of molecules found within the mix. Usually, steam distillation under high pressure is used to separate essential oils using the clevenger device. Furthermore, the oil may be chemically altered during distillation due to saponification, isomerization, and other reactions due to distillation. Essential oils are extracted
Most monoterpene has a cytotoxic effect on plant and animal cells, disrupting respiration and permeability, depleting Golgi and mitochondria, and decreasing respiration and production. Similarly, many serve as chemicals to animals and insects as well, and they are volatile. Also, most monoterpenoids act as some short-signal molecules, thus making them suitable as synonyms and alarm pheromones. Care must be taken with the number of essential oils used to destroy insects and their modes of action because of possible health hazards to humans and other vertebrates. There is still a lack of understanding about the monophenoid target sites and mode of action, and only a few studies have investigated this [1, 18, 44, 48].
Although insects are not known well for the physiological effects of essential oils, treating them with essential oils or their constituents causes symptoms that provide us information about the mode of action as a neurotoxin. Linalool, a monoterpenoid, has influenced ion transport and acetylcholine esterase release in insects [18].
Octopamine is a neurotransmitter, neurohormone, and circulating neurohormone—neuromodulator with many biological functions in insects [1]. Based on pharmacological parameters, octopamine works by interacting with at least two receptor groups, dubbed octopamine-1 and octopamine-2. As the octopamine system is disrupted, the nervous system of insects is wholly destroyed. As a result, the insect octopaminergic mechanism is a bio-rational priority for pest control (Figure 1).
Essential oils’ toxic activity can be mediated by neurotransmitters at target sites in insects.
Since vertebrates do not have octopamine receptors, essential oils have a solid mammalian selectivity as insecticides. The octopaminergic mechanism of insects is influenced by various important oil compounds [48].
In the cloned cells of
It is not clear if repellents function the same way in various arthropods likewise other published material disscussed. Ticks, for example, can detect repellents present on their tarsi of prolegs (Haller’s Organ), whereas insects can detect repellents through their antennae. Furthermore, sensitivity to the same repellent varies only in degree among different classes, orders, and families; no fundamental differences in response type are observed [18, 48]. However, in mosquitoes, the degree of differential sensitivity remained constant over several generations, suggesting that resistance is based on heritable traits. Temperature and moisture are sensitive to mosquito antennae hairs. The repellent molecules attach to the olfactory receptors of female mosquitos, preventing them from smelling. Cockroach repellent receptors are poorly understood. Death and aversion to death (repellence) have been linked to oleic acid and linoleic acid in cockroaches. A proposal has been made for the term necromone to characterize the compound responsible for this form of behavior [18, 48].
The essential oils with bioactivity as insecticides or repellents are well known for example, rosemary, thyme, clove, lemongrass, mint, oregano oils, and cinnamon. The bioactivity of certain plants, including thyme, oregano, basil, rosemary, and mint, varies widely because the composition differences in chemical compositions are reliable [48].
Understanding essential oils’ mode of action is critical for insect control because it can lead to better formulations, distribution methods, and resistance management. Many essential oils and their isolated chemicals from plants have fumigant properties.
There are no natural fumigants that have been proven to work against pests that attack crops, dry foods, and other agricultural products. Phosphine, methyl bromide, and DDVP are the most used fumigants (2,2-dichlorovinyl dimethyl phosphate). Phosphine is responsible for an enormous percentage of Indian suicides, as a precursor for ozone depletion is a concern. In contrast, Dichlorvos is an organophosphate widely used as an insecticide to control household pests, in public health, and protecting stored products from insects (used as the precursor for ozone-depleting treatments) poses a theoretical risk of cancer [48]. All attempts should be made to develop an alternative that can take toxic fumigation while being user-friendly and cost-effective. Many aromatic plants produce highly toxic or unpleasant chemicals but serve as some valuable deterrents for various insects. These three attributes (high molecular weight, high boiling point, and low vapor pressure of essential oils) allow large-forgery fumigation to be performed by the high fumigation standards of safety and efficiency, making them better suited for large-scale fumigation than most other substances [18]. Despite essential oils having the potential for low-scale applications and single or multiple component contaminants in food, there is a lack of scientific data on food-grade applications and fusible essential oils [48].
The synergistic rationale for combining products assumes that the combined product’s phase carries much weightage than the count of its known and unknown chemical components that result in a complex effect of multiple modes of action. Among the essential oils and their components and other ingredients used in formulating a product, both positive and negative types of synergism may occur. This is important to keep in mind because essential oils will work together to create a synergy that may negatively affect the base product. The salinity and pH of the base product can affect the actions of the essential oils.
Low pH and a saline environment (5% NaCl) have been shown in several studies to increase the activity of the entire product. Synergistic activity has been demonstrated for essential oil combinations such as thyme, anise, and saffron [1, 18, 48, 51]. Mixed monoterpene mixtures had a synergistic impact on mortality [5, 52]. For use against foliar-feeding pests, a monoterpene blend was produced containing 0.9% active ingredient.
Monoterpenoids bind to the octopaminergic receptor, which is only found in insects. A proprietary blend of essential oils called Hexa Hydrox (EcoPCO EcoSMART Technologies, Franklin, Tennessee) with different plant essential oils was developed to significantly increase the potency of these oils in pest control. This proprietary technology, which combines oils with a normal molecular structure to target octopaminergic sites, demonstrates rapid insecticidal action (a six-membered carbon ring with an oxygenated functional group attached). The US Food and Drug Administration has listed them as GRAS (Generally Recognized as Safe) and has licensed them for use in food and beverages [18, 48].
The toxicity of pesticides and the exposure of applicators or users influence the risks associated with their use. Pesticides are tested during the registration process in some cases. The assessments should include the acute toxicity for formulating products to determine the effective preventive measures by the recommendations issued by the FAO, UN, and the WHO. To assess the risk of health-associated to short-term exposure, the acute toxicity and metabolites or degradations of the active substances are assessed. Reproductive and developmental toxicity, carcinogenicity, and mutagenicity should be evaluated in determining risks related to long-term exposure, sub-chronic, and chronic effects.
Furthermore, farmworker and pesticide applicator exposure and residue in crop production should be assessed to determine whether the risks associated with pesticides used are tolerable [5]. There have been no or only partial safety tests of homemade botanical insecticides except for neem products. Homemade botanical insecticides vary from industrial pesticides. The former contains an active ingredient cocktail with unknown concentrations and a long list of variable concentrations of compounds with novel properties. Furthermore, although plant material concentrations may be poor, processing exposure has not been assessed and may be very high. As a result, even though safety tests are available, it is difficult to extrapolate the risks found in laboratory trials to real-world scenarios. Many countries’ plant protection laws prohibit homemade preparations, even though this is often the case in agriculture. As a result, some countries, at least for non-commercial farming, use such preparations [48].
In similarity with risks associated with human health, adverse pesticide uses depend on their toxicity and exposure to non-target organisms—such as pests, pollinators, birds, fish, and mammals. These risks should be evaluated to determine if they are accepted as a part of the registration process [5, 53]. For the registration of pesticides, environmental fatality data usually are also required. The risk of bioaccumulation with homemade botanical insecticides is generally less because they contain natural materials known to degrade faster than many synthetic compounds [48].
Despite the possibility that certain homemade botanical insecticides have lower toxicity to non-target organisms than broad-spectrum insecticides, these findings illustrate the importance of the further study. The application of botanical products should consider their possible negative effects on non-target organisms if it is appropriate and handled with care. Similarly, botanical products, including pesticides, should not be used alone to combat pests. Botanical products can be used in an integrated pest management system (IPM). It may be used with other non-pesticidal tools such as plant diversification, habitat protection, and other non-pesticidal tools.
The use of botanical insecticides should not be ignored in low-income countries. In addition to synthetic pesticides, botanical insecticides may be less active. They are still an option, especially in combination with the IPM approach, in areas where farmers either have no access to commercial pesticides or have limited affordability of these synthetic pesticides. As a result, food waste in some of the most depleted areas of the world has been reduced. It is important to remember and convey the risks associated with using natural insecticides (i.e., alterable effectiveness and possible health and environmental consequences).
Botanicals: natural insecticides derived from plant sources are used as the best alternate for conventional pesticides to protect our crops, avoiding adverse effects of synthetic insecticides. Botanical insecticides have a wide range of chemicals and their modes of action; they have a variety of the impact on insects. Thus, botanical insecticides are preferred over synthetic insecticides, and organic crop producers in developed countries accept these botanical insecticides. As a result, we advocated for the use of botanical insecticides, which has been encouraged, and research is underway to identify new botanical insecticide sources.
The author is grateful to Research Scientist Dr. Chamila Darshanee (Sri Lanka) for reviewing this chapter early. The authors would like to thank the Science and Technology Development (STDF), Egypt entitled: “Eco-friendly Pesticides against Pests of Medical, Veterinary, and Agricultural Importance” ID: 41608.
The authors declare no conflict of interest.
Authors take sole responsibility of no submission to any other source, journal, or publisher of the chapter submitted to IntechOpen.
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\\n\\nIntechOpen is a dynamic, vibrant company, where exceptional people are achieving great things. We offer a creative, dedicated, committed, and passionate environment but never lose sight of the fact that science and discovery is exciting and rewarding. We constantly strive to ensure that members of our community can work, travel, meet world-renowned researchers and grow their own career and develop their own experiences.
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Integrity - We are consistent and dependable, always striving for precision and accuracy in the true spirit of science.
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\n\nIntechOpen is a dynamic, vibrant company, where exceptional people are achieving great things. We offer a creative, dedicated, committed, and passionate environment but never lose sight of the fact that science and discovery is exciting and rewarding. We constantly strive to ensure that members of our community can work, travel, meet world-renowned researchers and grow their own career and develop their own experiences.
\n\nIf this sounds like a place that you would like to work, whether you are at the beginning of your career or are an experienced professional, we invite you to drop us a line and tell us why you could be the right person for IntechOpen.
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Since 1911, 500 kW power generation at Pharping, now reached 782.45 MW production in 2016. Nepal government has planned to increase its current 67.3% access in electricity to 1426 MW (87%), by 2022. Globally, 16.6% generation of hydroelectricity, 1,079 GW production, in 2015 will be increased to 1,473 GW by 2040 as projected. Although, hydropower is considered as a renewable clean energy, dam closure, influence within the downstream river and connected ecosystems have consequent impacts on hydropower production. Nepal’s topography offered more RoR types of hydropower and has more risk of landslide, flooding, GLOFs, LDOFs, and flash floods. Despite, Nepal contributes 0.027% of total global Green House Gas (GHG) emissions; Nepal has focused on renewable energy, hydropower production, targeting 12000 MW by 2030 to fulfill its growing demand of 11,500 MW. Consequent development of clean energy, GHG reduction, single Bhotekoshi hydropower can reduce 160092 tons CO2/year. The energy-related CO2 emissions increased 43.2 billion metric tons by 2040 globally, which can be reduced through promotion of clean energy.",book:{id:"5602",slug:"renewable-hydropower-technologies",title:"Renewable Hydropower Technologies",fullTitle:"Renewable Hydropower Technologies"},signatures:"Ramesh Prasad Bhatt",authors:[{id:"192574",title:"Dr.",name:"Ramesh",middleName:"Prasad",surname:"Bhatt",slug:"ramesh-bhatt",fullName:"Ramesh Bhatt"}]},{id:"49145",doi:"10.5772/60944",title:"Bioethanol and Biodiesel as Vehicular Fuels in Brazil — Assessment of Atmospheric Impacts from the Long Period of Biofuels Use",slug:"bioethanol-and-biodiesel-as-vehicular-fuels-in-brazil-assessment-of-atmospheric-impacts-from-the-lon",totalDownloads:1672,totalCrossrefCites:10,totalDimensionsCites:17,abstract:null,book:{id:"4542",slug:"biofuels-status-and-perspective",title:"Biofuels",fullTitle:"Biofuels - Status and Perspective"},signatures:"Thiago Nogueira, Denise de Sales Cordeiro, Rodrigo Alejandro\nAbarza Muñoz, Adalgiza Fornaro, Antonio H. Miguel and Maria de\nFatima Andrade",authors:[{id:"159270",title:"Prof.",name:"Rodrigo",middleName:null,surname:"Munoz",slug:"rodrigo-munoz",fullName:"Rodrigo Munoz"},{id:"172598",title:"Dr.",name:"Thiago",middleName:null,surname:"Nogueira",slug:"thiago-nogueira",fullName:"Thiago Nogueira"},{id:"175515",title:"Dr.",name:"Denise",middleName:null,surname:"Cordeiro",slug:"denise-cordeiro",fullName:"Denise Cordeiro"},{id:"175516",title:"Prof.",name:"Adalgiza",middleName:null,surname:"Fornaro",slug:"adalgiza-fornaro",fullName:"Adalgiza Fornaro"},{id:"175517",title:"Dr.",name:"Antonio",middleName:null,surname:"Miguel",slug:"antonio-miguel",fullName:"Antonio Miguel"},{id:"175518",title:"Prof.",name:"Maria",middleName:null,surname:"Andrade",slug:"maria-andrade",fullName:"Maria Andrade"}]}],mostDownloadedChaptersLast30Days:[{id:"53169",title:"Membrane Separation Technology in Carbon Capture",slug:"membrane-separation-technology-in-carbon-capture",totalDownloads:3983,totalCrossrefCites:8,totalDimensionsCites:26,abstract:"This chapter introduces the basics of membrane technology and the application of membrane separation in carbon capture processes. A number of membranes applicable in pre-combustion, post-combustion or oxy-fuel combustion have been discussed. An economic comparison between conventional amine-based absorption and membrane separation demonstrates the great potential in membrane technology.",book:{id:"5448",slug:"recent-advances-in-carbon-capture-and-storage",title:"Recent Advances in Carbon Capture and Storage",fullTitle:"Recent Advances in Carbon Capture and Storage"},signatures:"Guozhao Ji and Ming Zhao",authors:[{id:"190003",title:"Associate Prof.",name:"Ming",middleName:null,surname:"Zhao",slug:"ming-zhao",fullName:"Ming Zhao"},{id:"190139",title:"Dr.",name:"Guozhao",middleName:null,surname:"Ji",slug:"guozhao-ji",fullName:"Guozhao Ji"}]},{id:"53350",title:"Hydropower Development in Nepal - Climate Change, Impacts and Implications",slug:"hydropower-development-in-nepal-climate-change-impacts-and-implications",totalDownloads:3481,totalCrossrefCites:11,totalDimensionsCites:19,abstract:"Nepal has endowed high potential of water resources, covering 395,000 ha (48%) area within 45,000 km in length of 6000 rivers with 170 billion m3 annual runoff and 45,610 MW feasible hydroelectricity generation. Since 1911, 500 kW power generation at Pharping, now reached 782.45 MW production in 2016. Nepal government has planned to increase its current 67.3% access in electricity to 1426 MW (87%), by 2022. Globally, 16.6% generation of hydroelectricity, 1,079 GW production, in 2015 will be increased to 1,473 GW by 2040 as projected. Although, hydropower is considered as a renewable clean energy, dam closure, influence within the downstream river and connected ecosystems have consequent impacts on hydropower production. Nepal’s topography offered more RoR types of hydropower and has more risk of landslide, flooding, GLOFs, LDOFs, and flash floods. Despite, Nepal contributes 0.027% of total global Green House Gas (GHG) emissions; Nepal has focused on renewable energy, hydropower production, targeting 12000 MW by 2030 to fulfill its growing demand of 11,500 MW. Consequent development of clean energy, GHG reduction, single Bhotekoshi hydropower can reduce 160092 tons CO2/year. The energy-related CO2 emissions increased 43.2 billion metric tons by 2040 globally, which can be reduced through promotion of clean energy.",book:{id:"5602",slug:"renewable-hydropower-technologies",title:"Renewable Hydropower Technologies",fullTitle:"Renewable Hydropower Technologies"},signatures:"Ramesh Prasad Bhatt",authors:[{id:"192574",title:"Dr.",name:"Ramesh",middleName:"Prasad",surname:"Bhatt",slug:"ramesh-bhatt",fullName:"Ramesh Bhatt"}]},{id:"52867",title:"Emerging New Types of Absorbents for Postcombustion Carbon Capture",slug:"emerging-new-types-of-absorbents-for-postcombustion-carbon-capture",totalDownloads:2535,totalCrossrefCites:1,totalDimensionsCites:8,abstract:"Carbon capture is the most probable technology in combating anthropogenic increase of CO2 in the atmosphere. Works on developing emerging absorbents for improving carbon capture performance and reducing process energy consumption are actively going on. The most worked‐on emerging absorbents, including liquid‐liquid biphasic, liquid‐solid biphasic, enzymatic, and encapsulated absorbents, already show encouraging results in improved energy efficiency, enhanced CO2 absorption kinetics, increased cyclic CO2 loading, or reduced regeneration temperature. In this chapter, the latest research and development progress of these emerging absorbents are reviewed along with the future directions in moving these technologies to higher‐technology readiness levels.",book:{id:"5448",slug:"recent-advances-in-carbon-capture-and-storage",title:"Recent Advances in Carbon Capture and Storage",fullTitle:"Recent Advances in Carbon Capture and Storage"},signatures:"Quan Zhuang, Bruce Clements and Bingyun Li",authors:[{id:"189578",title:"Dr.",name:"Quan",middleName:null,surname:"Zhuang",slug:"quan-zhuang",fullName:"Quan Zhuang"},{id:"195678",title:"Dr.",name:"Bruce",middleName:null,surname:"Clements",slug:"bruce-clements",fullName:"Bruce Clements"},{id:"195679",title:"Dr.",name:"Bingyun",middleName:null,surname:"Li",slug:"bingyun-li",fullName:"Bingyun Li"}]},{id:"53621",title:"Design of Zero Head Turbines for Power Generation",slug:"design-of-zero-head-turbines-for-power-generation",totalDownloads:2244,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"Failure analysis of the blades of a horizontal axis hydrokinetic turbine of 1 kW is presented. Analysis consisted of the determination of the pressure on the blade surface using Computational Fluid Dynamics, and the calculation of the stress distribution in the blade due to hydrodynamic, inertial and gravitational loads using the finite element methods. The results indicate that the blade undergoes significant vibration and deflection during the operation, and the centrifugal and hydrodynamic loads considerably affect the structural response of the blade; however, the stresses produced in all of the analysed models did not exceed the safe working stresses of the materials used to manufacture the blade. Modal analysis was conducted to calculate first significant natural frequencies. Results were studied in depth against operating frequency of the turbine. After carrying out the modal analysis, harmonic analysis was also done to see the response of the turbine under dynamic loading. It was observed that the turbine is safe in its entire operating range as far as phenomenon of resonance is concerned. Additionally, it was observed that maximum harmonic response of the turbine on the application of dynamic loading is far lesser than its failure limit within the specified operating range.",book:{id:"5602",slug:"renewable-hydropower-technologies",title:"Renewable Hydropower Technologies",fullTitle:"Renewable Hydropower Technologies"},signatures:"Edwin Chica and Ainhoa Rubio-Clemente",authors:[{id:"189040",title:"Prof.",name:"Ainhoa",middleName:null,surname:"Rubio Clemente",slug:"ainhoa-rubio-clemente",fullName:"Ainhoa Rubio Clemente"},{id:"193744",title:"Prof.",name:"Edwin",middleName:null,surname:"Chica",slug:"edwin-chica",fullName:"Edwin Chica"}]},{id:"47886",title:"An Overview of Bioethanol Production From Algae",slug:"an-overview-of-bioethanol-production-from-algae",totalDownloads:5670,totalCrossrefCites:21,totalDimensionsCites:42,abstract:null,book:{id:"4542",slug:"biofuels-status-and-perspective",title:"Biofuels",fullTitle:"Biofuels - Status and Perspective"},signatures:"Didem Özçimen and Benan İnan",authors:[{id:"32444",title:"Dr.",name:"Didem",middleName:null,surname:"Özçimen",slug:"didem-ozcimen",fullName:"Didem Özçimen"}]}],onlineFirstChaptersFilter:{topicId:"788",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:13}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:8},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:229,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. 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