\nComparison between structural features of the samples after different milling times.
\r\n\tIt has been established that energy/nutrient depletion, calcium flux injury, or oxidative stress disrupt endoplasmic reticulum homeostasis and even induce accumulation of misfolded/unfolded proteins leading to endoplasmic reticulum stress. Under endoplasmic reticulum stress conditions, an adaptive mechanism of coordinated signaling pathways, defined unfolded protein response (UPR), is activated to return the endoplasmic reticulum to its healthy functioning state. The aging causes a decrease of the protective adaptive response of the UPR and an increase of the pro-apoptotic pathway together with endoplasmic reticulum ultrastructural injury. Controlling endoplasmic reticulum stress response, maintaining the appropriate endoplasmic reticulum ultrastructure and homeostasis, and retaining mitochondria interplay are crucial aspects for cellular health.
\r\n\r\n\tThis book presents a comprehensive overview of endoplasmic reticulum, including, but not limited to, endoplasmic reticulum ultrastructural anatomy, MAMs, endoplasmic reticulum stress, and their implication in health and diseases. Additionally, identifying perturbations in the endoplasmic reticulum stress response could lead to early detection of age-related disease and may help develop therapeutic approaches.
",isbn:"978-1-80356-228-5",printIsbn:"978-1-80356-227-8",pdfIsbn:"978-1-80356-229-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"5d7d49bd80f53dad3761f78de4a862c6",bookSignature:"Dr. Gaia Favero",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",keywords:"Metabolism, Aging, Neurodegenerative Diseases, Endoplasmic Reticulum, Microscopy, Metabolic Stress, Ultrastructural Anatomy, Cellular Stress, Contactology, Mitochondria, Cellular Stress, Endoplasmic Reticulum Response",numberOfDownloads:12,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 9th 2022",dateEndSecondStepPublish:"May 6th 2022",dateEndThirdStepPublish:"July 5th 2022",dateEndFourthStepPublish:"September 23rd 2022",dateEndFifthStepPublish:"November 22nd 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Human anatomy researcher involved in crucial topics on morphology, anatomy, and molecular medicine - working on innovative approaches to aging-related pathopsychological processes at the University of Brescia.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"238047",title:"Dr.",name:"Gaia",middleName:null,surname:"Favero",slug:"gaia-favero",fullName:"Gaia Favero",profilePictureURL:"https://mts.intechopen.com/storage/users/238047/images/system/238047.jpg",biography:'Dr. Gaia Favero is a prominent scientist in the field of life sciences. She is currently engaged as a researcher for the Scientific-Disciplinary Sector BIO/16 Human Anatomy at the Anatomy and Pathophysiology Division, Department of Clinical and Experimental Sciences, University of Brescia (Italy).\r\nDr. Favero focuses on aging-related morphological dysfunctions as the prelude to various pathophysiological processes in her research programs. The central hypothesis is that natural antioxidants and, in particular, melatonin may act as molecular "switches" that modulate cells and tissues by suppressing, at various levels, oxidative stress and inflammatory signalling cascades. These research approaches represent powerful tools for developing innovative preventive strategies and identifying novel prognostic biomarkers for several diseases. The above-reported research activity determined more than 120 scientific publications and an h-index of 25.',institutionString:"University of Brescia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Brescia",institutionURL:null,country:{name:"Italy"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"6",title:"Biochemistry, Genetics and Molecular Biology",slug:"biochemistry-genetics-and-molecular-biology"}],chapters:[{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:6,totalCrossrefCites:0,authors:[null]},{id:"82195",title:"Endoplasmic Reticulum: A Hub in Lipid Homeostasis",slug:"endoplasmic-reticulum-a-hub-in-lipid-homeostasis",totalDownloads:6,totalCrossrefCites:0,authors:[null]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"278926",firstName:"Ivana",lastName:"Barac",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/278926/images/8058_n.jpg",email:"ivana.b@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6694",title:"New Trends in Ion Exchange Studies",subtitle:null,isOpenForSubmission:!1,hash:"3de8c8b090fd8faa7c11ec5b387c486a",slug:"new-trends-in-ion-exchange-studies",bookSignature:"Selcan Karakuş",coverURL:"https://cdn.intechopen.com/books/images_new/6694.jpg",editedByType:"Edited by",editors:[{id:"206110",title:"Dr.",name:"Selcan",surname:"Karakuş",slug:"selcan-karakus",fullName:"Selcan Karakuş"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"37420",title:"New Frontiers in Mechanosynthesis: Hydroxyapatite – and Fluorapatite – Based Nanocomposite Powders",doi:"10.5772/50160",slug:"new-frontiers-in-mechanosynthesis-hydroxyapatite-and-fluorapatite-based-nanocomposite-powders",body:'\n\t\tMechanosynthesis process is a solid state method that takes advantage of the perturbation of surface-bonded species by pressure or mechanical forces to enhance the thermodynamic and kinetic reactions between solids. Pressure can be applied via conventional milling equipment, ranging from low-energy ball mills to high-energy stirred mills. In a mill, the reactants are crushed between the balls and wall (horizontal or planetary ball mill, attritor, vibratory ball mill), or between rings or ring and wall (multi–ring media mill) (Bose et al., 2009). These processes cause the creation of defects in solids; accelerate the migration of defects in the bulk, increase the number of contacts between particles, and renew the contacts. In these circumstances, chemical interaction occurs between solids (Avvakumov et al., 2002). This procedure is one of the most important fields of solid state chemistry, namely, the mechanochemistry of inorganic substances, which is intensively developed; so that, a large number of reviews and papers published on this subject in the last decades (Silva et al., 2003; Suryanarayana, 2001; De Castro & Mitchell, 2002). The prominent features of this technique are that melting is not essential and that the products have nanostructural characteristics (Silva et al., 2003; Suryanarayana, 2001; De Castro & Mitchell, 2002). In the field of bioceramics, high efficiency of the mechanochemical process opens a new way to produce commercial amount of nanocrystalline calcium phosphate-based materials. A review of scientific research shows that the mechanosynthesis process is a potential method to synthesis of nanostructured bioceramics (Rhee, 2002; Silva et al., 2004; Suchanek et al., 2004; Tian et al., 2008; Nasiri–Tabrizi et al., 2009; Gergely et al., 2010; Wu et al. 2011; Ramesh et al., 2012).
\n\t\t\tOn the other side, bioceramics play a vital role in several biomedical applications and have been expanding enormously the recent years (Adamopoulos & Papadopoulos, 2007). Among different forms of bioceramics, particular attentions have been placed to calcium phosphates-based powders, granules, dense or porous bodies, and coatings for metallic or polymeric implants due to their excellent biocompatibility and osteointegration properties (Marchi et al., 2009). It is well known that hydroxyapatite (HAp: Ca10(PO4)6(OH)2) is a major mineral component of bones and teeth (Zhou & Lee, 2011). Therefore, synthetic HAp has been extensively utilized as a bioceramic for maxillofacial applications owing to its excellent osteoconductive properties (Adamopoulos & Papadopoulos, 2007). Besides this field, in a variety of other biomedical applications calcium phosphates have been used as matrices for controlled drug release, bone cements, tooth paste additive, and dental implants (Rameshbabu et al., 2006). Nevertheless, HAp intrinsic poor mechanical properties (strength, toughness and hardness), high dissolution rate in biological system, poor corrosion resistance in an acid environment and poor chemical stability at high temperatures have restricted wider applications in load-bearing implants (Fini et al., 2003; Chen et al., 2005).
\n\t\t\tAccording to the literature (Jallot et al., 2005), the biological and physicochemical properties of HAp can be improved by the substitution with ions usually present in natural apatites of bone. In fact, trace ions substituted in apatites can effect on the lattice parameters, the crystallinity, the dissolution kinetics and other physical properties (Mayer & Featherstone, 2000). When OH− groups in HAp are partially substituted by F−, fluoride-substituted HAp (FHAp: Ca10(PO4)6(OH)2-xFx) is obtained. If the substitution is completed, fluorapatite (FAp: Ca10(PO4)6F2), is formed. When fluoride consumed in optimal amounts in water and food, used topically in toothpaste, and mouth rinses, it increases tooth mineralization and bone density, reduces the risk and prevalence of dental caries, and helps to promote enamel remineralization throughout life for individuals of all ages (Palmer & Anderson, 2001). It is found that the incorporation of fluorine into HAp induced better biological response (Rameshbabu et al., 2006). On the other hand, the incorporation of bioinert ceramics and addition of appropriate amount of ductile metallic reinforcements into calcium phosphate-based materials has demonstrated significant improvement in structural features as well as mechanical properties. Therefore, improvements on structural, morphological, and mechanical properties of HAp ceramics have been tried by a number of researches (Cacciotti et al., 2009; Schneider et al., 2010; Farzadi et al., 2011; Pushpakanth et al., 2008; Rao & Kannan, 2002; Viswanath & Ravishankar, 2006; Gu et al., 2002; Ren et al., 2010). These studies have shown that such characteristics of HAp might be exceptionally strengthened by various methods such as making nanocomposites, use of different sintering techniques, and adding dopants. In the field of nanocomposites, an ideal reinforcing material for the HAp-based composites, which satisfies all of the requirements, has not yet been found. Thus, synthesis and characterization of novel nanostructured calcium phosphate-based ceramics provided the key target for current research. In most researches (Enayati–Jazi et al., 2012; Rajkumar et al., 2011; Choi et al., 2010), calcium phosphate-based nanocomposites were prepared using multiple wet techniques which ordinarily comprise of several step processes. Over the past decades, the mechanochemical synthesis has been extended for the production of a wide range of nanostructured materials (Suryanarayana, 2001), particularly for the synthesis of nanocrystalline calcium phosphate-based ceramics (Rhee, 2002; Suchanek et al., 2004; Tian et al., 2008; Nasiri–Tabrizi et al., 2009; Gergely et al., 2010; Wu et al. 2011; Ramesh et al., 2012). The advantages of this procedure remains on the fact that melting is not necessary and the powders are nanocrystalline (Silva et al., 2007).
\n\t\t\tIn this chapter, a new approach to synthesis of HAp- and FAp-based nanocomposites via mechanochemical process is reported. The effect of high-energy ball milling parameters and subsequent thermal treatment on the structural and morphological features of the nanocomposites were discussed in order to propose suitable conditions for the large scale synthesis of HAp- and FAp-based nanocomposites. Powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and energy dispersive X-ray spectroscopy (EDX) techniques are used to provide evidence for the identity of the samples. Transmission electron microscopy (TEM), Field-Emission Scanning Electron Microscope (FE-SEM), and scanning electron microscopy (SEM) are also utilized to study of the morphological features of the nanocomposites. Literature reported that the size and number of balls had no significant effect on the synthesizing time and grain size of FAp ceramics, while decreasing the rotation speed or ball to powder weight ratio increased synthesizing time and the grain size of FAp (Mohammadi Zahrani & Fathi, 2009). On the other hand, our recent experimental results confirm that the chemical composition of initial materials and thermal annealing process are main parameters that affect the structural features (crystallinity degree, lattice strain, crystallite size) of the products via mechanochemical method (Nasiri-Tabrizi et al., 2009; Honarmandi et al., 2010; Ebrahimi-Kahrizsangi et al., 2010; Fahami et al., 2011; Ebrahimi-Kahrizsangi et al., 2011; Fahami et al., 2012). Consequently, the present chapter is focused on the mechanochemical synthesize of HAp- and FAp-based nanocomposites. In the first part of this chapter, an overview of recent development of ceramic-based nanocomposites in biomedical applications and mechanochemical process are provided. The other sections describe the application of these procedures in the current study. The effects of milling media and atmosphere to prepare novel nanostructured HAp-based ceramics are studied. Moreover, mechanochemical synthesis and characterization of nanostructured FAp-based bioceramics are investigated.
\n\t\tOver the past decades, innovations in the field of bioceramics such as alumina, zirconia, hydroxyapatite, fluorapatite, tricalcium phosphates and bioactive glasses have made significant contribution to the promotion of modern health care industry and have improved the quality of human life. Bioceramics are mainly applied as bone substitutes in biomedical applications owing to their biocompatibility, chemical stability, and high wear resistance. However, the potential of bioceramics in medical applications depends on its structural, morphological, mechanical, and biological properties in the biological environment. The first successful medical application of calcium phosphate bioceramics in humans is reported in 1920 (Kalita et al., 2007). After that the first dental application of these ceramics in animals was described in 1975 (Kalita et al., 2007). In a very short period of time, bioceramics have found various applications in replacements of hips, knees, teeth, tendons and ligaments and repair for periodontal disease, maxillofacial reconstruction, augmentation and stabilization of the jawbone and in spinal fusion (Kalita et al., 2007).
\n\t\t\tToday, many specialty ceramics and glasses have been developed for use in dentistry and medicine, e.g., dentures, glass-filled ionomer cements, eyeglasses, diagnostic instruments, chemical ware, thermometers, tissue culture flasks, fiber optics for endoscopy, and carriers for enzymes and antibodies (Hench, 1998). Among them, calcium phosphate-based bioceramics have been utilized in the field of biomedical engineering due to the range of properties that they offer, from tricalcium phosphates (
One of the primary restrictions on clinical use of bioceramics is the uncertain lifetime under the complex stress states, slow crack growth, and cyclic fatigue that result in many clinical applications. Two creative approaches to these mechanical limitations are use of bioactive ceramics as coatings, and the biologically active phase in composites. Because of the anisotropic deformation and fracture characteristics of cortical bone, which is itself a composite of compliant collagen fibrils and brittle HAp crystals, the Young’s modulus varies ~ 7–25 GPa, the critical stress intensity ranges ~ 2–12 MPa.m1/2, and the critical strain intensity increases from as low as ~ 600 J.m−2 to as much as 5000 J.m−2, depending on orientation, age, and test condition. On the contrary, most bioceramics are much stiffer than bone and many exhibit poor fracture toughness (Hench, 1998). Therefore, the only materials that exhibit a range of properties equivalent to bone are composites. For this reason, many attempts have been made to improve the mechanical properties as well as structural features through the incorporation of ceramic second phases (Viswanath & Ravishankar, 2006; Evis, 2007; Nath et al., 2009; Ben Ayed & Bouaziz, 2008). These studies have shown that the mechanical properties of HAp and fluoridated HAp might be exceptionally strengthened by composite making technique.
\n\t\t\tIt is found that (Kong et al., 1999) the following conditions should be satisfied to be effective as a reinforcing agent for a ceramic matrix composite material. First, the strength and the elastic modulus of the second phase must be higher than those of the matrix. Second, the interfacial strength between the matrix and the second phase should be neither too weak nor too strong. Indeed, for an appropriate interfacial strength, no excessive reaction should occur between the matrix and the second phase. Third, the coefficient of thermal expansion (CTE) of the second phase should not differ too much from that of the matrix in order to prevent micro-cracks formation in densification process. Fourth, in the case of biomaterials, the biocompatibility of the reinforcing agent is another crucial factor that should be considered. Nevertheless, an ideal reinforcing material for the calcium phosphate-based composites, which satisfies all of requirements, has not yet been found. So, some attempts have been made to develop HAp- and fluorhydroxyapatite-based composites such as HAp–Al2O3 (Viswanath & Ravishankar, 2006), HAp–ZrO2 (Evis, 2007), HAp–TiO2 (Nath et al., 2009), FHAp–Al2O3 (Adolfsson et al., 1999), FHAp–ZrO2 (Ben Ayed & Bouaziz, 2008), poly(lactide-co-glycolide)/
To date, several approaches, including wet chemical methods (Mobasherpour et al., 2007; Kivrak & Tas, 1998), hydrothermal processes (Liu et al., 2006), solid−state reaction (Silva et al., 2003), and sol–gel method (Balamurugan et al., 2002), have been developed for synthesis of nanobioceramics. Among them, mechanochemical process has been extended for the production of a wide range of nanostructured materials (Suryanarayana, 2001; De Castro & Mitchell, 2002). According to literature (Bose et al., 2009), mechanochemical synthesis was originally designed for the production of oxide dispersion-strengthened (ODS) alloys. Over the past 20 years, however, the number of available mechanochemical synthesis has grown, such that Nowadays it is used for the fabrication of a wide range of advanced materials, both metallic and nonmetallic in composition. In mechanosynthesis, the chemical precursors typically consist of mixtures of oxides, chlorides and/or metals that react either during milling or during subsequent thermal treatment to form a composite powder consisting of the dispersion of ultrafine particles within a soluble salt matrix. The ultrafine particle is then recovered by selective removal of the matrix phase through washing with an appropriate solvent.
\n\t\t\tMechanochemical approach is a very effective process for synthesizing nanocomposites with various classes of compounds: metals, oxides, salts, organic compounds in various combinations. For example, Khaghani-Dehaghani et al. (Khaghani-Dehaghani et al., 2011) synthesized Al2O3–TiB2 nanocomposite by mechanochemical reaction between titanium dioxide, acid boric and pure aluminum according to the following reactions:
\n\t\t\tTitanium diboride has an attractive combination of high Vickers hardness, electrical conductivity, excellent chemical resistance to molten nonferrous metals and relatively low specific gravity (Gu et al., 2008). However, titanium diboride has poor fracture toughness and impact strength. Thus, the composites of TiB2 such as Al2O3–TiB2 improve those mechanical properties. These nanocomposites are useful in variety of applications such as cutting tools, wear-resistant substrates, and lightweight armor (Mishra et al., 2006). Results reveal that the Al2O3–TiB2 nanocomposite was successfully synthesized after 1.5 h of milling. Also, the determined amounts of structural features demonstrate that after 20 h of milling the steady state was obtained. Increasing milling time up to 40 h had no significant effect other than refining the crystallite size. The SEM and TEM observations show that increase of milling time was associated with decrease of powder particles, so that a fine structure was produced after 40 h of milling. Figure 1 shows the morphological features of the Al2O3–TiB2 nanocomposite powders after 40 h of milling by SEM and TEM. It is clear that the particles exhibited high affinity to agglomerate. The agglomerates include fine particles of TiB2 and Al2O3.
\n\t\t\tThermodynamic studies, based on thermodynamic databases, show that the change in Gibbs free energy of the reduction of boron oxide and titanium oxide with aluminum (Eqs. (3) and (4)) is favorable at room temperature.
\n\t\t\tIt is well known if a reaction is highly exothermic, the impact of the milling balls can initiate a mechanically induced self-sustaining reaction (MSR) (Xia et al., 2008). MSR was usually observed in highly exothermic reactions. The ignition of MSR takes place after a certain activation time, during which the powder mixtures reach a critical state due to the physical and chemical changes caused by ball milling (Takacs, 2002; Takacs et al., 2006). That certain activation time depends mainly on the exothermicity of the process, the milling conditions and the mechanical properties of the raw materials. Takacs (Takacs, 2002) showed that a reaction can propagate in the form of a self sustaining process, if ΔH/C, the magnitude of the heat of reaction divided by the room temperature heat capacity of the products, is higher than about 2000 K. The calculations on the system Al–B2O3–TiO2 show that the value of ΔH/C is about 5110 K. Therefore, the proposed reactions occurred through an expanded MSR reaction in milled samples which led to the formation of Al2O3–TiB2 nanocomposite after short milling times.
\n\t\t\ta) SEM micrograph and (b) TEM image of Al2O3–TiB2 nanocomposite after 40 h of milling (
HAp and its isomorphous modifications are valuable and prospective materials in biomedical applications. Therefore, a large number of studies was performed on this subject in the last decade (Rhee, 2002; Silva et al., 2004; Suchanek et al., 2004; Tian et al., 2008; Nasiri-Tabrizi et al., 2009; Gergely et al., 2010; Wu et al. 2011; Ramesh et al., 2012). Generally, the fabrication methods of HAp nanostructures can be classified into two groups: wet and dry (Rhee, 2002). The advantage of the wet process is that the by-product is almost water and as a result the probability of contamination during the process is very low. On the other hand, the dry process has benefit of high reproducibility and low processing cost in spite of the risk of contamination during milling. Furthermore, the dry mechanochemical synthesis of HAp presents the advantage that melting is not necessary and the powder obtained is nanocrystalline. The calcium and phosphorous compounds used as the starting materials in the dry process are dicalcium phosphate anhydrous (CaHPO4), dicalcium phosphate dihydrate (CaHPO4.2H2O), monocalcium phosphate monohydrate (Ca(H2PO4)2.H2O), calcium pyrophosphate (Ca2P2O7), calcium carbonate (CaCO3), calcium oxide (CaO), and calcium hydroxide (Ca(OH)2), etc.
\n\t\t\t\t\n\t\t\t\t\tOtsuka et al. (Otsuka et al., 1994) investigated the effect of environmental conditions on the crystalline transformation of metastable calcium phosphates during grinding. Based on the results, the mixture of CaHPO4 and Ca(OH)2 transformed into low-crystallinity HAp after grinding in air. Nevertheless, under N2 atmosphere, a mixture of initial materials did not transform into HAp. After that, Toriyama et al. (Toriyama et al., 1996) proposed a method to prepare powders and composite ceramic bodies with a matrix comprising HAp. The powders Was produced by the utilization of a simple and economic mechanochemical method. The composite ceramic bodies were easily obtained by simple firing of the powders at a suitable temperature (1250 C). After sintering, the obtained products exhibited a flexural strength of more than 100 MPa in standard samples. This value is significantly higher than that usually attainable with commercially available powders (60 MPa). In another research (Yeong et al., 2001), nanocrystalline HAp phase has been produced by high-energy mechanical activation in a dry powder mixture of CaO and CaHPO4. The initial stage of mechanical activation resulted in a significant refinement in crystallite and particle sizes, together with a degree of amorphization in the starting powder mixture. A single-phase HAp of high crystallinity was attained by >20 h of mechanical activation. The resulting HAp powder exhibits an average particle size of ~ 25 nm. It was sintered to a density of 98.20% theoretical density at 1200 C for 2 h. The hardness increases almost linearly with rising sintering temperature from 900 to 1200 C, where it reaches a maximum of 5.12 GPa. This is followed by a slight decrease, to 4.92 GPa, when the sintering temperature is raised to 1300 C. Afterward, Rhee (Rhee, 2002) synthesized HAp powder by mechanochemical reaction between Ca2P2O7 and CaCO3. The two powders were mixed in acetone and water, respectively, and the single phase of HAp was observed to occur only in the powder milled in water, without the additional supply of water vapor during heat-treatment at 1100 C for 1 h. The results indicated that the mechanochemical reaction could supply enough amount of hydroxyl group to the starting powders to form a single phase of HAp. Therefore, the powder of high crystalline HAp can be obtained by the simple milling in water and subsequent heat-treatment. With the development of nanostructured materials using mechanochemical processes, nanocrystalline powders of HAp was produced in 2003 by Silva et al. (Silva et al., 2003). To produce nanocrystalline powders of HAp, five different experimental procedures in a pure dry process were utilized. For four different procedures, HAp was obtained after a couple of hours of milling (in average 60 h of milling, depending in the reaction procedure). In the preparation of nanocrystalline HAp, commercial oxides Ca3(PO4)2.xH2O, Ca(OH)2, CaHPO4, P2O5, CaCO3 and (NH4)H2PO4 were used in the HAp preparation. This milling process, presents the advantage that melting is not necessary and the powder obtained is nanocrystalline with crystallite size in the range of 22 nm to 39 nm. Subsequently, Silva et al. (Silva et al., 2004) synthesized nanocrystalline powders of HAp using three different experimental procedures (HAPA: Ca(H2PO4)2 + Ca(OH)2; HAPB: Ca(H2PO4)2 + CaCO3; and HAPC: CaHPO4 + CaCO3). Nanocrystalline HAp was obtained after 5, 10 and 15 h of milling in the reactions HAPA and HAPB, but it is necessary 15 h of milling in the reaction HAPC to obtain HAP. Moreover, in order to improve the mechanical properties of HAp calcium phosphate ceramics, with titanium (CaP-Ti) and zirconium (CaP-Zr), were prepared by dry ball milling using two different experimental procedures: CaP-Ti1: Ca(H2PO4)2 + TiO2; CaP-Ti2: CaHPO4 + TiO2; and CaP-Zr1: Ca(H2PO4)2 + ZrO2, CaP-Zr2: CaHPO4 + ZrO2. The calcium titanium phosphate phase, CaTi4P6O24, was produced in the reaction CaP-Ti1. In the reactions CaP-Ti2, CaP-Zr1 and CaP-Zr2, it was not observed the formation of any calcium phosphate phase even after 15 h of dry mechanical alloying.
\n\t\t\t\tNanocrystalline HAp powders were synthesized by the mechanochemical–hydrothermal method using emulsion systems consisting of aqueous phase, petroleum ether (PE) as the oil phase and biodegradable Tomadol 23–6.5 as the nonionic surfactant (Chen et al., 2004). (NH4)2HPO4 and Ca(NO3)2 or Ca(OH)2 were used as the phosphorus and calcium sources, respectively. The calcium source and emulsion composition had significant effects on the stoichiometry, crystallinity, thermal stability, particle size, and morphology of final products. Disperse HAp crystals with a 160 nm length were formed in an emulsion system containing 10 wt% PE, 60 wt% water, and 30 wt% surfactant. The HAp particles had needle morphology with a specific surface area of 190 m2/g. According to obtained results, HAp nanopowders with specific surface areas in the range of 72–231 m2/g were produced. In the same year, Mochales et al. (Mochales et al., 2004) investigated the possibility of mechanochemistry to synthesize calcium deficient HAp (CDHA) with an expected molar calcium to phosphate (Ca/P) ratio ± 0.01. To optimize the experimental conditions of CDHA preparation from dicalcium phosphate dihydrate (DCPD) and calcium oxide by dry mechanosynthesis reaction, the kinetic study was carried out with two different planetary ball mills (Retsch or Fritsch Instuments). Results obtained with the two mills led to the same conclusions although the values of the rate constants of DCPD disappearance and times for complete reaction were very different. Certainly, the origin of these differences was from the mills used, thus the influence of instrumental parameters such as the mass and the surface area of the balls or the rotation velocity were examined on the mechanochemical reaction kinetics of DCPD with CaO. Results exhibited that the DCPD reaction rate constant and the inverse of the time for complete disappearance of CaO both vary linearly with (i) the square of the rotation velocity, (ii) the square of eccentricity of the vial on the rotating disc and (iii) the product of the mass by the surface area of the balls. The consideration of these four parameters allows the transposition of experimental conditions from one mill to another or the comparison between results obtained with different planetary ball mills. Gonzalez et al. (Gonzalez et al., 2006) studied the mechanochemical transformation of two mixtures: Ca(OH)2–(NH4)2HPO4 and Ca(OH)2–P2O5, milled in a mortar dry grinder for different periods of time. Mechanical grinding and thermal treatment was a successful method to obtained biphasic mixtures of HAp/
A new approach to mechanochemical synthesis of HAp nanostructures was developed in 2009 by Nasiri-Tabrizi et al. (Nasiri–Tabrizi et al., 2009). Single-crystal HAp nanorods and nanogranules synthesized successfully by a mechanochemical process using two distinct experimental procedures.
\n\t\t\t\t\tThe feasibility of using polymeric milling media to prepare HAp nanoparticles is described. By controlling the temperature and milling time during mechanical activation (45-min milling steps with 15-min pauses), powders with three different crystallite size, lattice strain and crystallinity degrees are produced. Figure 2 presents the XRD patterns of reactions 5 and 6, respectively. The XRD patterns show that the product of reaction 5 is HAp. The extra peaks (CaHPO4, ■) occurred in 2θ = 26.59 and 30.19 , consecutively. In reaction 6, the extra peaks are not observed after 40, 60 and 80 h of milling and the only detected phase is HAp, as shown in Figure 2(b). Therefore, during milling process, CaHPO4 is a compound that should be avoided if the purpose is to achieve pure HAp without any extra phase presentation. In order to determine crystallite size and lattice strain in activated samples, the full width at half maximum (FWHM) of each peak is usually considered. Furthermore, the fraction of crystalline phase (
According to obtained data, the crystallite size decreases and the lattice strain increases with increase of milling time. However, the rate of both variations, i.e. increasing lattice strain and decreasing crystallite size, decreases by increasing the milling time. Furthermore, the obtained data show that by choosing the total milling time to 80 h for reaction 5, the crystallinity degree increases first and reaches to a maximum at 60 h of milling, and then by further increasing the milling time to 80 h, the crystallinity degree decreases. Moreover, the increase of HAp crystallinity compared to the increase of milling time was not linear. The fraction of crystalline phase in the HAp powders from reaction 6 indicates that by increasing the milling time from 40 to 80 h, the crystallinity degree decreases mostly after 60 h and reaches to a minimum at 80 h of milling time. Based on these results, we conclude that the chemical composition of initial materials and the milling time are important parameters that affect the structural properties of product via mechanochemical process.
\n\t\t\t\t\tThe morphological features of the synthesized HAp products were further examined by TEM technique. Figures 3 and 4 show the TEM micrographs of nanorods and nanogranules, respectively. Figure 3a shows that the sample possesses a mostly rod-like structure after 60 h milling time in polymeric milling vial for reaction 5. In Figure 3b, it can be seen that the morphology of nanocrystalline HAp after 80 h milling time, similar to 60 h, is also the rod shape; although, few particles appear to be close to a spherical shape. Using HAp nanorods as raw materials is an effective way to obtain dense bioceramics with high mechanical properties. Hence, this product may be used as strength enhancing additives for the preparation of the HAp ceramics or biocompatible nanocomposites.
\n\t\t\t\t\tXRD patterns of samples milled for 60 and 80 h, (a) reaction 5 and (b) reaction 6. (
Typical TEM micrograph of nanorods HAp after 60 h (a) and 80 h (b) milling time for reaction 5 (
In reaction 5, more agglomeration also occurs by increasing milling time from 60 h to 80 h. In fact, the obtained product nearly had a uniform geometry distribution just after 60 h milling time. Although, it may appear some ellipse or round like shapes from this image, it is due to the axis orientation of nanorods with respect to the image plane. In other words, if the rod axis is perpendicular or oblique on the image plane, the rod may be seen as a full circle or ellipse, respectively. Despite of previous research that a perfect spherical shape rarely observed in the mechanically alloyed powders, nanosphere particles were successfully obtained. In Figure 4, it can be seen that the morphology of nanocrystalline HAp for reaction 6, either after 60 or 80 h milling time, is absolutely spherical granules with a reasonable smooth geometry.
\n\t\t\t\t\tTherefore, we reach to an important conclusion that using polyamide-6 milling vial leads to the spherical granules HAp. Since spherical geometry compared to irregular shape is important for achieving osseointegration (Komlev et al., 2001; Nayar et al., 2006; Hsu et al., 2007), the latest product is well preferred for medical applications. Similar to previous reaction, the obtained product after 60 h has a better uniform geometry distribution than one after 80 h milling time. It should be noted that the HAp particles out of reaction 5 are in average length of 17 ± 8 nm and 13 ± 7 nm after 60 and 80 h milling time, respectively. Similarly, the HAp particles out of reaction 6 are in average diameter of 16 ± 9 nm and 15 ± 8 nm after 60 and 80 h milling time. Based on obtained data, the maximum particle distribution is below the crystallite size which is estimated from the line broadening of the given X-ray diffraction peak.
\n\t\t\t\t\tTypical TEM micrograph of nanospheres HAp after 60 h (a) and 80 h (b) milling time for reaction 6 (
Thus, after 80 h milling time, we ascertain that this method gives rise to the single-crystal HAp with their average size below 20 nm and 23 nm for reactions 6 and 7, respectively. In fact, a novel method for the synthesis of nanosize single-crystal HAp is developed in both spherical and rod-like particles.
\n\t\t\t\tHonarmandi et al. (Honarmandi et al., 2010) investigated the effects of milling media on synthesis, morphology and structural characteristics of single-crystal HAp nanoparticles. Typical TEM images of nanosize HAp particles produced through reactions 5 and 6 after being milled in both metallic and polymeric vials have been shown in Figure 5.
\n\t\t\t\t\tMorphologies of HAp synthesized through reactions 5 after being milled for 60 h in (a) metallic vials and (b) polymeric vials; through reactions 6 after being milled for 60 h in (c) metallic vials and (d) polymeric vials.
The results reveal that the single-crystal HAp nanoparticles have been successfully produced in metallic and polymeric vials through two different experimental procedures. Transmission electron microscopy images illustrate the wide morphology spectrums of the single-crystal HAp nanoparticles which are ellipse-, rod- and spherical-like morphologies each of which can be applied for specific purpose. After 60 h milling, this method results in the single-crystal HAp with their average sizes below 21 and 24 nm in the tempered chrome steel and polyamide-6 vials, respectively. According to TEM images the obtained single-crystal HAp in polymeric vials have more production efficiency and better uniform geometry distribution than products in metallic vials. In metallic vial, intense agglomeration happens during mechanochemical process as shown in Figure 6. Therefore, an important conclusion reaches that the polyamide-6 vial is more suitable than the tempered chrome steel vial for the synthesis of single-crystal HAp nanoparticles with appropriate morphology.
\n\t\t\t\tTEM images of agglomerated products which is obtained after 60 h milling in metallic vials through a (a) reaction 5 and (b) reaction 6 (Honarmandi et al., 2009).
In recent years, various mechanochemical processes were utilized to synthesis HAp nanostructures. For instance, Gergely et al. (Gergely et al., 2010) synthesized HAp by using recycled eggshell. The observed phases of the synthesized materials were dependent on the mechanochemical activation method (ball milling and attrition milling). Attrition milling proved to be more efficient than ball milling, as resulted nanosize, homogenous HAp even after milling. SEM micrographs showed that the ball milling process resulted in micrometer sized coagulated coarse grains with smooth surface, whereas attrition milled samples were characterized by the nanometer size grains. Wu et al. (Wu et al. 2011) synthesized HAp from oyster shell powders by ball milling and heat treatment. The wide availability and the low cost of oyster shells, along with their biological– natural origin are highly attractive properties in the preparation of HAp powders for biomedical application. Chemical and microstructural analysis has shown that oyster shells are predominantly composed of calcium carbonate with rare impurities. Solid state reactions between oyster shell powders (calcite polymorph of CaCO3) and calcium pyrophosphate (Ca2P2O7) or dicalcium phosphate dihydrate (CaHPO4.2H2O, DCPD) were performed through ball milling and subsequently heat treatment. The ball milling and heat treatment of Ca2P2O7 and oyster shell powders in air atmosphere produced mainly HAp with a small quantity of
XRD patterns, crystallite size, lattice strain and their average of samples milled for 40 and 80 h in polymeric and metallic vials under argon atmosphere.
Mechanosynthesis of calcium phosphates can be performed under air or inert gas atmosphere. In most papers and patents, grinding under air atmosphere was selected. So far, only a few papers were devoted to mechanosynthesis of calcium phosphates under inert gas atmosphere (Nakano et al, 2001). To understand the effect of inert gas atmosphere, the mechanochemical synthesis under argon atmosphere was investigated by our research group. The starting reactant materials are CaCO3 and CaHPO4. The initial powders with the desired stoichiometric proportionality were mixed under a purified argon atmosphere (purity> 99.998 vol %). Figure 7 shows the XRD patterns of the powder mixture after 40 and 80 h of milling in the polymeric and metallic vials under argon atmosphere. The XRD patterns of obtained powders exhibit that the production of mechanical activation is single phase HAp. Also, Figure 7 illustrates the determined amounts of crystallite size; lattice strain and their average for experimental outcomes after 40 and 80 h of milling in polymeric and metallic vials under argon atmosphere.
\n\t\t\t\t\tTypical TEM micrograph of nanocrystalline HAp after 80 h of milling under argon atmosphere in (a) polymeric and (b) metallic vials.
a) XRD profile and (b) FE-SEM images of nanocrystalline HAp with low degree of crystallinity after 2 h of milling in polymeric vial under air atmosphere.
Using the (0 0 2) plane (Figure 7a), the crystallite size of HAp is around 43 and 34 nm after 40 h of milling in polymeric and metallic vials, respectively. For comparison, the mean values determined from the use of six planes simultaneously, i.e. (0 0 2), (2 1 1), (3 0 0), (2 2 2), (2 1 3), and (0 0 4) planes. The calculated data indicates that the average crystallite size of HAp is around 40 and 34 nm, respectively. Moreover, using the (0 0 2) plane the crystallite size of HAp is around 34 and 28 nm after 80 h of milling in polymeric and metallic vials, respectively. However, the average crystallite size of HAp is around 34 and 31 nm after 80 h of milling in polymeric and metallic vials, respectively. The evaluation of the lattice strain of HAp reveals that the average of lattice strain partially increased from 0.286 % to 0.340 % after 80 h of milling in polymeric vial. A similar trend was observed in the average lattice strain of HAp after 80 h of milling. According to Figure 7, the average crystallite size decreases and the average lattice strain increases with increase of milling time from 40 up to 80 h. The TEM micrographs of synthesized powder after 80 h of milling in polymeric and metallic vials under argon atmosphere are shown in Figure 8. The TEM micrographs show that HAp particles can attach at crystallographically specific surfaces and form scaffold- and chain-like cluster composed of many primary nanospheres. In is found that (Pan et al., 2008) the living organisms build the outer surface of enamel by an oriented assembly of the rod-like crystal and such a biological construction can confer on enamel protections against erosion. It should be noted that, comparison of the physical, mechanical and biocompatibility between classical HAp ceramics and the novel nanostructures will be carried out in our laboratory.
\n\t\t\t\t\tWhilst the main advantages of the mechanochemical synthesis of ceramic powders are simplicity and low cost, the main disadvantages are the low crystallinity and calcium-deficient nonstoichiometry (Ca/P molar ratio 1.50 – 1.64) of the HAp powders, as this results in their partial or total transformation into
\n\t\t\t\t\t\tFigure 9b shows the morphology and particle size distribution of the nanocrystalline HAp produced after 2 h of milling. From the FE–SEM micrograph, it is clear that the powders displayed an agglomerate structure which consisted of several small particles with the average size of about 58 nm. In the field of science and technology of particles, agglomerate size is one of the key factors that influence the densification behaviors of nanoparticles. Large particle size along with hard agglomerates shows lower densification in calcium phosphate ceramics due to the formation of large interagglomerate/intraagglomerate pores (Banerjee et al., 2007). The large interagglomerate/intraagglomerate pores increase the diffusion distance, resulting in lowering the densification rate. Thus, to compensate for this, higher sintering temperature becomes necessary.
\n\t\t\t\t\tXRD patterns of the HAp-20%wt Ti nanocomposite after mechanochemical process for various time periods (
SEM micrographs of the HAp-20 wt.% Ti nanocomposite after different milling times (a) 5, (b) 10, (c) 15, (d) 20, (e) 40, and (f) 50 h.
Apart from the displacement reactions to reduce oxides, chlorides, and sulfides to pure metals, mechanical alloying technique was also used to synthesize a large number of commercially important alloys, compounds, and nanocomposites using the mechanochemical reactions (Suryanarayana, 2001; De Castro & Mitchell, 2002; Balaz, 2008). An important characteristic of mechanosynthesized composites is that they have nanocrystalline structures which could improve the mechanical as well as biological properties (Silva et al., 2007). Nowadays, ceramic nanocomposites which play a crucial role in technology can be synthesized using surprisingly simple and inexpensive techniques such as a mechanochemical method which ordinarily include a two step process. Considering the above characteristics of the ceramic-based composites, the possibility of using one step mechanochemical process as a simple, efficient, and inexpensive method to prepare HAp-20wt.% Ti nanocomposite was investigated by our research group (Fahami et al., 2011). Furthermore, crystallite size, lattice strain, crystallinity degree, and morphological properties of products were determined due to the biological behaviour of HAp ceramics depends on structural and morphological features. For the preparation of HAp-20 wt.% Ti nanocomposite, anhydrous calcium hydrogen phosphate and calcium oxide mixture with Ca/P = 1.67 ratio was milled with the distinct amount of elemental titanium (20 wt.%) during 0, 5, 10, 15, and 20 h by a high energy planetary ball mill under highly purified argon gas atmosphere. The following reaction can be occurred at this condition (8):
\n\t\t\t\t\t\n\t\t\t\t\t\tFigure 10 shows the XRD patterns of the samples after mechanochemical process for various time periods. At the initial mixture, only sharp characteristic peaks of CaHPO4, CaO and Ti are observed. With increasing milling time to 5 h, the sharp peaks of starting materials degraded significantly, but the decreasing rate of each initial powder was differed. On the other hand, the appearance of weak peak between 31 and 32 confirms the formation of HAp phase. The main products of powder mixtures after 10 h of milling were HAp and Ti. The XRD patterns of the samples which are milled for 15 and 20 h indicate that increasing milling time to above 10 h does not accompany with any phase transformation. The determined amounts of crystallite size and lattice strain of the samples, after different milling time were presented in Table 1. According to Table 1, the crystallite size of HAp decrease with increasing milling time up to 20 h; whereas the change in crystallite size of Ti with increasing milling time is not linear. The calculated amount of crystallinity degree indicate that the increasing milling time dose not accompany by remarkable change in degree of crystallinity. Since the amorphous powders could find applications to promote osseointegration or as a coating to promote bone ingrowth into prosthetic implants (Sanosh et al., 2009), the resultant powders could be used to various biomedical applications.
\n\t\t\t\t\tSamples | \n\t\t\t\t\t\t\t\tMilling time (h) | \n\t\t\t\t\t\t\t\tCrystallite size (nm) | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | Lattice strain (%) | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | Crystallinity (%) | \n\t\t\t\t\t\t\t||
\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t | HAp | \n\t\t\t\t\t\t\t\tTi | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | HAp | \n\t\t\t\t\t\t\t\tTi | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t |
I | \n\t\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t\t- | \n\t\t\t\t\t\t\t\t22.8 | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | - | \n\t\t\t\t\t\t\t\t0.494 | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | - | \n\t\t\t\t\t\t\t
II | \n\t\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t\t\t20.13 | \n\t\t\t\t\t\t\t\t18.7 | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | 0.492 | \n\t\t\t\t\t\t\t\t0.621 | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | 17 | \n\t\t\t\t\t\t\t
III | \n\t\t\t\t\t\t\t\t15 | \n\t\t\t\t\t\t\t\t19.06 | \n\t\t\t\t\t\t\t\t19.3 | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | 0.522 | \n\t\t\t\t\t\t\t\t0.601 | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | 15 | \n\t\t\t\t\t\t\t
IV | \n\t\t\t\t\t\t\t\t20 | \n\t\t\t\t\t\t\t\t13.13 | \n\t\t\t\t\t\t\t\t22 | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | 1.209 | \n\t\t\t\t\t\t\t\t0.530 | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | 13 | \n\t\t\t\t\t\t\t
\nComparison between structural features of the samples after different milling times.
The SEM micrographs of the samples after different milling times are presented in Figure 11. It can be seen that the particles of products can be attached together at specific surfaces and form elongated agglomerates which composed of many primary crystallites. The agglomerates with flaky-like structure formed after 10 h of milling. It seems that the existence of ductile Ti can be led to the more agglomeration during mechanochemical process. With increasing milling time to 20 h owing to sever mechanical deformation introduced into the powder, particle, and crystal refinement have occurred. Based on SEM observations, milling process reached steady state after 40 h of milling where the particles have become homogenized in size and shape. Figure 12 shows the SEM images of the HAp-20wt.% Ti nanocomposite after 40 and 50 h of milling and subsequent heat treatment at 700 C for 2h. According to SEM observations, the annealing of the milled samples at 700 C demonstrates the occurrence of grain growth.
\n\t\t\t\tSEM micrographs of the HAp-20 wt.% Ti nanocomposite after different milling times (a) 40 and (b) 50 h and subsequent heat treatment at 700 C for 2h.
In the field of nanocomposites, an ideal reinforcing material for calcium phosphate-based composites has not yet been found. Nevertheless, different approaches have been extensively investigated in order to develop calcium phosphate-based composites. Despite a large number of studies on the synthesis of HAp and TCP composites (Viswanath & Ravishankar, 2006; Rao & Kannan, 2002; Nath et al., 2009; Jin. et al., 2010; Cao & Kuboyama, 2010; Hu et al., 2010), no systematic investigations on the preparation of HAp/MgTiO3−MgO are performed. Therefore, a novel approach to synthesis of HAp/MgTiO3−MgO nanocomposite has developed by our research group (Fahami et al., 2012). In this procedure, the starting reactant materials are CaHPO4, CaO, titanium dioxide (TiO2), and elemental magnesium (Mg). Synthesis of HAp/MgTiO3−MgO composite nanopowders consists of: (i) mechanical activation of powder mixture, and (ii) subsequently thermal treatment at 700 C for 2 h. The obtained mixture was milled in a high energy planetary ball mill for 10 h according to the following reaction.
\n\t\t\t\t\t\n\t\t\t\t\t\tFigure 13 shows the XRD profiles of the CaHPO4, CaO, TiO2, and Mg powder mixture after 10 h of milling and after thermal annealing at 700 C for 2 h. As can be seen, the product of mechanochemical process in presence of 20 wt.% (TiO2, Mg) is HAp/MgO−TiO2 composite. From Figure 13b, it was verified the existence of HAp and geikielite (MgTiO3) phases together with minor MgO phase after the annealing at 700 ºC. This suggests that the thermal treatment at 700 ºC led to the formation of MgTiO3 by the following reaction:
\n\t\t\t\t\tXRD patterns of the samples: (a) HAp/MgO−TiO2 after 10 h of milling, and (b) HAp/MgTiO3−MgO after 10 h of milling + heat treatment at 700 ºC (
\n\t\t\t\t\t\tFigure 14 shows the SEM micrographs and EDX results of the samples after milling and thermal treatment. As can be seen in Figure 15a, a very fine structure was formed after 10 h of milling. After thermal treatment at 700 ºC (Figure 14c), continuous evolution of the morphological features was appeared. The mean size of the powder particles increased after thermal treatment; however, only a slight change in particle size was observed in heat treated sample at 700 ºC compare to the milled powder. After milling and subsequent thermal treatment at 700 ºC, the products were composed of fine particles with a mean particle size of about 482 and 510 nm, respectively. Figures 14b and d represent the EDX results for HAp-based composites which are synthesized after 10 h of milling and subsequent heat treatment at 700 ºC. EDX data show that the main elements of the calcium phosphate-based composite nanopowders are calcium, phosphorus, oxygen, magnesium, and titanium. The EDX of HAp crystal, present in the HAp/MgO−TiO2 composite exhibit a molar ratio Ca/P = 1.93, whereas in the HAp/MgTiO3−MgO composite the molar ratio of calcium to phosphorus is greater (Ca/P = 2.87). These results suggest that the HAp crystals are closer to the expected value for the molar ratio of calcium to phosphorus ratio for the standard HAp (Ca/P = 1.67) (Cacciotti et al., 2009) and commercial HAp (2.38) (Silva et al., 2002), respectively. It is noteworthy to mention that chemically stable contaminants were not detected due to the excessive adhesion of powders to the vial and balls. Figure 15 demonstrates the TEM images of the HAp/MgTiO3−MgO composite nanopowders produced after 10 h of milling and subsequent annealing at 700 ºC for 2h. As can be seen, the agglomerates with mean size of about 322 nm were developed after thermal treatment at 700 ºC. In this sample, the cluster-like shape particles were composed of fine spheroidal shape crystals with a mean size of about 55 nm. It should be mentioned that chemical interactions at the contacting surface of crystals resulted in cluster-like shape aggregates which were composed of fine spheroidal shape crystals. This phenomenon is referred to the nature of milling process which originates through repeated welding, fracturing and re-welding of fine powder particles (Suryanarayana, 2001; De Castro & Mitchell, 2002). It is found that MgO-doped HAp/TCP ceramics present high density and significantly enhance mechanical properties without any phase transformation of
The inorganic matrix of the bone is based on HAp doped with different quantities of cations, such as Na+, K+ and Mg2+, and anions, such as CO3\n\t\t\t\t\t2−, SO4\n\t\t\t\t\t2− and F−. Among them, F− plays a leading role because of its influence on the physical and biological characteristics of HAp (Nikcevic et al., 2004). In the recent years, fluoridated HAp (FHAp and FAp) has attracted much attention as a promising material to replace HAp in biomedical applications (Kim et al., 2004a; Fathi & Mohammadi Zahrani, 2009). It is found that the incorporation of fluoride ions into the HAp structure considerably increases the resistance of HAp to biodegradation and thermal decomposition (Fathi et al., 2009). In addition, fluoridated hydroxyapatite could provide better protein adsorption (Zeng et al., 1999) and comparable or better cell attachment than HAp (Kim et al., 2004b). This substitution also has positive effects on proliferation, morphology and differentiation of osteoblastic-like cells and promotes the bioactivity (Fathi et al., 2009). For all these reasons, synthesis of FHAp and FAp is of great value and has been widely investigated by multiple techniques, such as precipitation (Chen & Miao, 2005), sol–gel (Cheng et al., 2006), hydrolysis (Kurmaev et al., 2002), hydrothermal (Sun et al., 2012), and mechanochemical methods (Nikcevic et al., 2004).
\n\t\t\t\tSEM micrographs and EDX results of the samples: (a-b) HAp/MgO−TiO2 after 10 h of milling, (c-d) HAp/MgTiO3−MgO after 10 h of milling + heat treatment at 700 ºC for 2 h.
TEM images of the HAp/MgTiO3−MgO composite nanopowders after 10 h of milling + heat treatment at 700 ºC for 2 h (
Nikcevic et al. (Nikcevic et al., 2004) synthesized nanostructured fluorapatite/fluorhydroxyapatite and carbonated fluorapatite/fluorhydroxyapatite by mechanochemical process. Powder mixture of Ca(OH)2-P2O5-CaF2 were milled in planetary ball mill. A carbonated fluorhydroxyapatite, FHAp was formed after 5 h of milling and carbonated fluoroapatite was formed after 9 h of milling. Complete transformation of the carbonated form of FAp into the single phase of FAp occurred after 9 h milling and thermally treating. After that, Zhang et al. (Zhang et al., 2005) synthesized FHAp from the starting materials of CaCO3, CaHPO4.2H2O, and CaF2 via a mechanochemical–hydrothermal route. The mechanism study revealed that under such mechanochemical–hydrothermal conditions the formation reactions of FHAp were completed in two stages. The starting materials firstly reacted into a poorly crystallized calcium-deficient apatite and the complete incorporation of fluoride ions into apatite occurred in the second stage.
\n\t\t\t\tFlow sheet of FAp nanoparticles preparation (
Along with the development of mechanochemical processes, Mohammadi Zahrani & Fathi (Mohammadi Zahrani & Fathi, 2009) evaluated the effect of ball milling parameters on the synthesis of FAp nanopowder; also, the effect of fluoridation on bioresorbability and bioactivity of apatite was studied. Fluoridated hydroxyapatite nanopowders with 100% (FAp) were synthesized via mechanical alloying method. The results showed that the size and number of balls had no significant effect on the synthesizing time and grain size of FAp, while decreasing the rotation speed or ball to powder weight ratio increased synthesizing time and the grain size of FAp. In vitro test indicated that the bioactivity of FAp was less than HAp since the dissolution rate, precipitation amount and the size of precipitated bone-like apatite crystals on the surface of FAp samples was clearly lower than HAp (Nikcevic et al., 2004; Zhang et al., 2005). Recently, Ebrahimi-Kahrizsangi et al. (Ebrahimi-Kahrizsangi et al., 2011) synthesized FAp nanostructures from the starting materials of CaHPO4, Ca(OH)2, CaO, P2O5 and CaF2 via mechanochemical process. The suitability of using the mechanochemical process to prepare a high crystalline phase of FAp was studied. FAp nanopowders with different structural characteristics synthesized through novel dry mechanochemical processes, which are presented in Figure 16.
\n\t\t\t\t\tXRD patterns and morphological features of the FAp nanostructures (
The purpose of the milling was twofold: first, to activate the following reactions via mechanochemical processes, and second, to produce the nanostructured FAp.
\n\t\t\t\t\ta) XRD patterns, and (b-d) structural features of CaHPO4-Ca(OH)2-CaF2-TiO2 powder mixture, mechanically alloyed for 2-20 h. (e) XRD profile of the FAp–TiO2 nanocomposite after heat treatment at 650 C (
\n\t\t\t\t\t\tFigure 17 illustrates XRD patterns and morphological features of the FAp nanostructures. XRD patterns of the FA1 and FA2 samples showing that the powders synthesized through the two different mechanochemical processes are mostly FAp. Complete agreement with the standard card of fluorapatite (JCPDS #15-0876) was not observed for FA1 due to the presence of additional peaks at 2θ = 26.59◦ and 30.19◦. These additional peaks were attributed to CaHPO4 from the starting materials. In FA2, complete agreement with JCPDS #15-0876 was observed, allowing FA2 to be used as the pure FAp phase sample when required. The results from the structural studies indicate that the maximum lattice disturbance in the apatite structure after the mechanochemical process was at the (0 0 2) plane. According to TEM images, the FA1 particles are spheroidal with an average diameter of 25 ± 5 nm. \n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tHowever, it should be noted that the particles do not possess high regularity in shape; in other words, their surfaces are not smooth. The particles show a high tendency towards agglomeration. In addition, the sample FA2 possesses a mostly spherical structure with an average diameter of 31 ± 6 nm. The TEM image of the FA3 sample confirms that the particles are spheroidal with an average diameter of 30 ± 7 nm. As shown in Figure 17, the TEM image of sample FA4 shows the particles to be more spherical than the unheated FA2 particles, and the average size of the particles is 29 ± 9 nm. Based on the obtained data, the maximum particle size measured with TEM is below the crystallite size calculated from the line broadening of the X-ray diffraction peak. Thus we concluded that, after 60 h of milling and subsequent thermal treatment at 600 C, this method gives rise to single-crystal FAp with average sizes of 30, 37, 37 and 38 nm for FA1, FA2, FA3 and FA4, respectively. In most reports concerning the synthesis of FAp, the particle shapes are plates (Rameshbabu et al., 2006) or polyhedral (Barinov et al., 2004; \n\t\t\t\t\t\t\tFathi & Mohammadi Zahrani, 2009\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t), but nanoparticles with spheroidal morphology were successfully prepared by current approach. Because the spherical geometry rather than irregular shape is important for achieving osseointegration (Hsu et al., 2007; Nayar et al., 2006), the products synthesized via mechanochemical processes are preferred for medical applications.
\n\t\t\t\tAs a fact that the incorporation of bioinert ceramics into calcium phosphate-based materials has demonstrated significant improvement in mechanical properties without substantial compromise in biocompatibility, some attempts have been made to develop FHAp-based composites such as: FHAp–Al2O3 (Adolfsson et al., 1999), and FHAp–ZrO2 (Kim et al., 2003; Ben Ayed & Bouaziz, 2008) composites. However, only a few studies have been devoted to the use of solid state reaction in order to prepare FAp nanocomposites (Bouslama et al., 2009). Therefore, synthesis of FAp–TiO2 nanocomposite which can present advantages of both TiO2 and FAp were carried out by Ebrahimi-Kahrizsangi et al. (Ebrahimi-Kahrizsangi et al., 2011). Based on XRD patterns and FT-IR spectroscopy, correlation between the structural features of the nanostructured FAp–TiO2 and the process conditions was investigated. The starting reactant materials are CaHPO4, Ca(OH)2, CaF2, and TiO2. In the production of the nanocomposite, a distinct amount of titanium dioxide (20 wt.%) was mixed with CaHPO4, Ca(OH)2 and CaF2 according to reaction (13), and were milled in planetary ball mill for 2, 5, 10, 15, and 20 h under ambient air atmosphere. The aims of the milling were twofold: the first one was to activate the following reaction via one step mechanochemical process, and the secondly, was to produce the FAp–TiO2 nanocomposite.
\n\t\t\t\t\t\n\t\t\t\t\t\tFigure 18a shows the XRD patterns of CaHPO4–Ca(OH)2–CaF2–TiO2 powder mixture, mechanically alloyed for 2-20 h. An XRD pattern of the mixture before milling is given in the same figure for comparison. For the powder mixture, milled for 2 h, all the sharp peaks corresponding to Ca(OH)2, CaF2 have diminished, and those corresponding to CaHPO4 have been broadened, indicating that a significant refinement in crystallite and particle sizes of the starting powders had occurred together with a degree of amorphization at the initial stage of mechanical activation. Also, the X-ray pattern of the sample, milled for 2 h, shows the most intense peaks for TiO2. Upon 5 h of mechanical activation, several new broadened peaks especially between 2θ = 31 –34 appear to emerge, corresponding to FAp phase. This suggests that nanocrystalline FAp phase has been formed as a result of mechanical activation. According to XRD profile, the main products of mechanochemical process after 5 h of milling were FAp and TiO2. Also, the two minor peaks observed in XRD patterns correspond to CaHPO4. When the mechanical activation time is extended to 15 h, all the peaks corresponding to CaHPO4 have disappeared and only those belonging to FAp and TiO2 are detectable.
\n\t\t\t\t\tSEM micrograph and TEM image of FAp–TiO2 nanocomposite after 20 h of milling (
\n\t\t\t\t\t\tFigures 18b and c show the variations of the crystallite size, lattice strain, and the volume fraction of grain boundaries of FAp as a function of milling time. Mechanical activation up to 15 h leads to a rapid decrease in the crystallite size to less than 16 nm, and a large increase in the volume fraction of grain boundary to 17.55%. Upon 15 h of mechanical activation, the crystallite size and the volume fraction of grain boundary reach about 16 nm and 16.54%, respectively. The evaluation of the lattice strain indicates that the lattice strain significantly increased with mechanical activation until 15 h, and then decreased slightly with further milling up to 20 h. The determined amounts of the crystallite size and the lattice strain of TiO2 as reinforcement are presented in Figure 18 d. The crystallite size of TiO2 remains nearly constant with milling until 10 h, and then decreases severely with further mechanical activation up to 15 h. After 20 h of milling, the lattice strain decreases which leads to an increase in the crystallite size. According to data presented in Figure 18 with further mechanical activation up to 20 h for both matrix and reinforcement, the lattice strain can be decreased at higher milling intensities because of the enhanced dynamical recrystallisation. Because the calcium phosphate ceramics with higher crystallinity degree has lower activity towards bioresorption and lower solubility in physiological environment (Sanosh et al., 2009), thermal recovery of crystallinity was performed at 650 C for 2 h. Some increase in the peak intensity of the crystalline FAp phase was observed in the XRD pattern (Figure 18e). The crystalline phase of titanium dioxide (TiO2) similarly appeared upon annealing. After heat treatment, the breadth of the fundamental diffraction peaks decrease as compared to the results of the milled powder which can be attributed to an increase in crystallite size and a decrease in lattice strain. The determined amounts of the structural features indicated that the crystallite size and lattice strain of FAp reached 43.3 nm and 0.30%, respectively.
\n\t\t\t\t\tXRD patterns and morphological features of the FAp-ZrO2 composite nanopowders after 5 h of milling.
The SEM micrograph, EDX result, and TEM image of the mechanosynthesized FAp–20 wt.%TiO2 nanocomposite after 20 h of mechanical activation time are shown in Figure 19. After 20 h of milling, the mean size of powder particles decreased due to severe mechanical deformation introduced into the powder. It also emerged from SEM image, that the fine agglomerates consist of significantly finer agglomerates/particles that cannot be seen individually in micrographs because of their exceptionally small sizes. Therefore, the size and morphology of fine powders was determined by using transmission electron microscopy. The results of measurements of elemental composition by EDX confirm that very homogeneous distribution of components is formed during one step mechanochemical process particularly after 20 h of milling. The results of EDX analysis also reveal that no chemically stable contaminants are detected due to the excessive adhesion of powders to the milling media. From TEM images it is clearly seen that the synthesized powder after 20 h of milling has an appropriate homogeneity. Also, the particles of products are in average size of about 15 nm after 20 h of milling, respectively. Due to high surface energy, the nanostructured materials can improve the sinterability and, thus, improve mechanical properties (Suryanarayana, 2001). Of course, sintering behavior not only depends on particle size, but also on particle size distribution and morphology of the powder particles. Large particle size along with hard agglomerates shows lower densification in calcium phosphate ceramics. On the other hand, difference in shrinkage between the agglomerates is also responsible to produce small cracks in the sintered calcium phosphate-based ceramic (Banerjee et al., 2007). Therefore, preparation of agglomerate free or soft agglomerated nanostructured FAp–20 wt.%TiO2 can be an important parameter to achieve good mechanical properties for dense nanostructure. The results of SEM and TEM images suggest that the formation of FAp–20 wt.%TiO2 nanocomposite after 20 h of milling does not accompany hard agglomerates and, therefore, the synthesized powder can present appropriate mechanical properties.
\n\t\t\t\tAmong the reinforcement materials of ceramic-based bionanocomposites, ZrO2 as a bioinert reinforcement has been studied extensively because of its relatively higher mechanical strength and toughness (Rao & Kannan, 2002; Ben Ayed & Bouaziz, 2008; Evis, 2007). However, the addition of ZrO2 results in lowering the decomposition temperature of microcrystalline HAp- and FHAp-based composites below the sintering temperature which causes an adverse influence on the mechanical properties (Kim et al., 2003). These phenomena are related to structural features of composite that are affected by the synthesis process. Generally, in order to prepare HAp/FHAp–ZrO2 composites, calcium phosphate source chemicals and ZrO2 powders are mixed, cold pressed and then sintered at high temperatures (Rao & Kannan, 2002). Under these conditions, the resulting product could have microcrystalline structure. Since the nanocrystalline structure compared to the microcrystalline structure is more important to achieve high thermal stability and mechanical properties, the FAp–ZrO2 composites with nanostructural characteristics are preferred for medical applications. In fact, the composite nanopowders can improve the sinterability as well as mechanical properties due to high surface energy. For all these reasons, our research group was considered to synthesis of FAp–ZrO2 nanocomposite with appropriate structural features via one step mechanochemical process. For this aim, commercially available calcium oxide (CaO), phosphorous pentoxide (P2O5), calcium fluoride (CaF2), and monoclinic zirconia (
\n\t\t\t\t\t\tFigure 20 shows the XRD patterns and SEM images of FAp-ZrO2 composite nanopowders after mechanical activation for 5 h. An XRD pattern of the mixture before milling is also given in the same figure for comparison. As can be seen in this figure, only sharp characteristic peaks of CaO and CaF2 could be detected at the initial mechanical activation of starting powder mixture. Phosphoric acid was formed immediately upon addition of P2O5 to the reaction mixture due to very high hydrophilic of P2O5. Therefore, characteristic peaks of P2O5 could not be observed. On the other hand, the CaO is not stable and will spontaneously react with H2O and CO2 from the air that leading to formation of Ca(OH)2 and CaCO3 in powder mixture. According to the XRD patterns, it can be seen that after 5 h of milling, all the peaks corresponding to CaO have vanished and only those belonging to FAp and
Hydroxyapatite- and fluorapatite-based nanocomposite powders have been developed and demonstrate huge potential for a variety of biomedical applications such as controlled drug release, bone cements, tooth paste additive, and dental implants. Different types of calcium phosphate-based nanocomposites can be synthesized by various approaches for instance wet chemical methods, hydrothermal processes, solid−state reaction, sol–gel method, and mechanochemical processes. Compared to various synthesis processes, mechanosynthesis method present a number of advantages such as high efficiency and enabling to synthesis a wide range of novel advanced materials (nanocomposites). It has been proved that the structural, mechanical, and biological properties of bioceramics can be significantly improved by using calcium phosphate-based nanocomposites as the advanced materials. For this reason, many attempts have been made to improve the mechanical properties as well as structural features of bioceramics through the incorporation of ceramic second phases. Mechanochemical synthesis of hydroxyapatite- and fluorapatite-based nanocomposite powders are of great interest and should be further explored. Although mechanochemical process have demonstrated their great potential for synthesis of hydroxyapatite- and fluorapatite-based nanocomposite powders, several challenges still remain. Mechanosynthesis of nanocomposites with precisely controlling their chemical composition, phases, biological characteristics, mechanical properties, and interfacial features is still a challenging task. Depending on the preparation circumstances (milling atmosphere, milling time, milling temperature, and type of milling media) and chemical composition of initial materials, the properties and performance of the nanocomposites can vary significantly; therefore, the ability to reproduce calcium phosphate-based nanocomposites with unique characteristics is very important for their wide use as biomaterials. With the increased interests and intensive research and development in the field of mechanochemistry, it is expected that, mechanosynthesized nanocomposites will have a promising future and will make a significant influence on the advanced materials industry.
\n\t\tThe authors are grateful to research affairs of Islamic Azad University, Najafabad Branch and Iranian Nanotechnology Initiative Council (INIC) for supporting this research.
\n\t\tAccording to the World Health Organization, an estimated 80% of people around the world use herbal medicine. Studies show that certain herbs effectively treat several health issues, like allergies, premenstrual syndrome, chronic fatigue, cancer, diabetes and many more. India is one of the big resources of medicinal plants and natural products due to its geological diversity. In recent years, various researches have been conducted on medicinal plants and spices worldwide. Plant-derived chemicals have attracted the attention of the scientific community for their various potential positive qualities. Studies have shown that polyphenols are anti-oxidants, anti-inflammatory, cardiac and neuroprotective, as well as having anti-cancer properties [1, 2]. Some of these natural chemicals have been included in clinical trials due to their inherent biological activity in a variety of disease models [3, 4], as they exhibited promising benefits in terms of boosting the anti-proliferative response and reducing the toxicity of conventional treatments.
Islamic medicine, often known as Arabic medicine in medical history, is the science of medicine developed during the Islamic Golden Age, which lasted from the ninth to thirteenth centuries. Although the main medical tradition was Greek, it was influenced by Islamic or Prophetic Medicine, as well as folk medicine to a lesser extent. The Holy Quran has provided the knowledge for a variety of crops, including grains, seeds, and fodder, as well as their germination and growth processes in several Surah. Plants are considered a gift from God, and the Quran mentions various plant names such as Date palms, figs, olives, ginger, grapes, miswak, onion, barley, garlic, pomegranates, camphor, Christ’s thorns, bottle gourds and other significant therapeutic herbs and plants utilized as food [5, 6].
Various medicinal plants and nutraceuticals derived from different natural resources, as well as their products such as polyphenolic components, flavones, flavonoids, and antioxidants, have been found to provide significant protection against a variety of diseases [7]. Epidemiological observations show that various traditional Islamic medicinal plants have powerful disease inhibiting properties [6, 8]. Currently, developing a preventive/therapeutic drug that reduces the particular disease without harming normal cells, is the primary goal of the research performed. For instance, in the case of cancer treatment, some of the methods used by the experts to cure the condition include tumor debulking, chemotherapies, radiotherapies, targeted treatments, immunotherapies, stem cell transplants, and photodynamic therapies [9]. Around the world, researchers are trying to develop new strategies to eradicate the diseases.
The present chapter summarizes the recently reported pharmacologically and therapeutically based medicinal plants and its products mentioned in Islamic scriptures. The chapter also highlights the recent studies of medicinal plants and their natural products based on
Date palm fruit has been described in traditional and alternative medicine to provide several health benefits including anticholesteremic, antidiabetic, anti-inflammatory, antioxidant, hepatoprotective and anticancer effects [12]. According to prior phytochemical studies, Date pulp fruit contains about 80% reducing sugars, including fructose, glucose, galactose, and maltose, as well as flavonoids, glycosides, polyphenols, and phytosterols [13, 14]. Phytochemicals present in dates palm fruits exhibit anti-inflammatory, cardioprotective, antioxidant, hypolipidemic and anti-apoptotic properties [15]. The main bioactive components present dates palm pulp are Carotenoids (lutein and β-carotene), phytosterols and phytoestrogens (β-sitosterol, stigmasterol, campesterol, daidzein, genistein and isofucosterol), flavonoids (apigenin, luteolin, quercetin, isoquercetrin, rutin and kaempferol) and phenolic acids (benzoic acid derivatives; p-hydroxybenzoic acid, protocatechuic acid, vanillic acid, gallic acid and syringic acid, and cinnamic acid derivatives; o-coumaric acid, p-coumaric acid, caffeic acid, and ferulic acid) (Figure 1) [10, 16].
Chemical structure of principal bioactive components found in date palm (
The ethyl acetate fraction of
Low glycemic index (GI) diets have been proven to be effective in the treatment of diabetes. Dates can be classed as a low GI superfood because of their high fructose content, which is sweeter and less diabetogenic than glucose [23].
The use of dates is also important for antimicrobial activities. The
Date palm fruit has shown the protective effect on dimethoate induced-oxidative stress in rat liver [28]. Moreover, date palm fruits have shown anti-hyperlipidemic and hepatoprotective effects in hyperlipidemia and fatty liver male albino rats [29].
The use of dates is especially important for pregnant and postnatal women. Women who consume dates before and after giving birth might strengthen their uterine muscles by consuming dates [20]. Consumption of date fruit in the last 4 weeks before labor reduced the need for initiation and augmentative labor and resulted in a better delivery outcome [30]. Due to their high fiber, iron and trace element contents, as well as their high energy and low GI, date fruits seem to be the ideal superfood for today’s health-conscious age.
One of the largest angiosperm genus, Ficus belonging to the family of Moraceae (Mulberry) are perennial plants comprising of over 800 different species including climbers, trailers, and epiphytes distributed around the tropical and sub-tropical regions worldwide [31, 32].
Bush/small tree-like appearance with single, alternating and large foliage, deep lobes with three or seven lobes; rough and hairy on the top surface; soft and hairy underneath along with smooth and gray bark. In addition to being cultivated from ancient times, they were found growing in the wild in dry and sunny places with rich and fresh soil, as well as in rocky locations. A reasonably permeable and easy draining soil is ideal for the plant’s growth; nevertheless, it can also grow in nutritionally poor soil [34]. The edible part of
Figs have acquired a considerable amount of folkloric importance and still invite the attention of researchers globally for their pharmaceutical properties to be used as complementary medicine. Ayurveda, Unani, and Siddha are the classical medicine systems of Ayurveda that have acknowledged the medicinal benefits of fig [39]. Therefore, it promises to treat and cure disorders of endocrine (diabetes), ventilatory, cardiovascular, digestive (ulcers and vomiting), urinary, reproductive (menstrual discomfort), and immune systems, as well as infectious diseases of the skin, scabies, and gonorrhea [40].
Phytochemical analysis results revealed a number of secondary metabolites being isolated from different parts of
Linolenic acid (53.1%) was found to be the most prominent fatty acid present in dried figs followed by linoleic acid (21.1%), palmitic acid (13.8%), and oleic acid (9.8%) [41]. Phenolic compounds; 3-O- and 5-O-caffeoylquinic acids, ferulic acid, quercetin-3-O-glucoside, quercetin-3-O-rutinoside, psoralen, and bergapten isolated from the fruit pulp [43]. However, numerous volatile components namely 3-methyl-butanal, 2-methyl-butanal, (E)-2-pentanal, hexanal, heptanal, octanal, and nonanal, 1-penten-3-ol, 3-methylbutanol, benzyl alcohol, (E)-2-nonenol, and phenylethyl alcohol, ketone: 6-methyl-5-hepten-2-one, esters: methyl hexanoate, methyl salicylate, and ethyl salicylate, limonene, menthol, α-pinene, β-pinene, linalool, eucalyptol, α-cubenene, copaene, β-caryophyllene, τ-muurolene, τ-cadinene, and germacrene D and β-cyclocitral were found in the
Chemical structure of principal bioactive components found in fig (
The fruits have emerged as an outstanding complementary medicine that could be used in treating leprosy, nasal hemorrhage, and deficiency disorders as well as are used in various drug preparations [45].
Methanolic fruit extract of
Methanolic fruit extract of
As a promising nutritional intervention for acute postprandial glucose and insulin homeostasis,
In a previous study, it has been found that the fig seems to have a spasmolytic action that might be mediated by activation of the K+-ATP channel, which supports some of its therapeutic uses in hyperactive gastrointestinal illnesses, and its antiplatelet effect [51].
Various therapeutic attributes of black seed and its active component thymoquinone have been shown in
The most important active compounds are thymoquinone (30–48%), thymohydroquinone, dithymoquinone, p-cymene (7–15%), carvacrol (6–12%), 4-terpineol (2–7%), t-anethol (1–4%), sesquiterpene longifolene (1–8%) α-pinene and thymol [62]. Among the various active components reported thus far, thymoquinone, which is a major component of essential oil, is the most bioactive chemical and has a variety of therapeutic properties (Figure 3).
Chemical structure of principal bioactive components found in black cumin (
Thymoquinone, the active compound of the black seed helps to train T cells
Black cumin is one of the most inspirational medicinal plants, with potent antibacterial, antifungal, antiviral, and antiparasitic properties. Thymoquinone isolated from
The administration of black cumin seed to streptozotocin-induced diabetic rats for one month resulted in a significant decrease in fasting plasma glucose, serum MDA, interleukin-6, and immunoglobulin A, G, and M, as well as a significant increase in endogenous antioxidant enzymes such as SOD, Glutathione-S-transferase, and catalase expression. Diabetes-induced elevations in tissue MDA and blood glucose were greatly reduced in rats treated with
According to a nonrandomized controlled trial, 57 patients who were given 2 g daily supplements of black cumin for one year showed a significant reduction in systolic, diastolic, and mean arterial BP, heart rate, TC, LDL-c, the fractions of TC/HDL-c, and LDL-c/HDL-c, while serum HDL-c was suggestively raised when compared to baseline values and the control group. It was also used to assess the blood pressure-lowering capability and possible processes of
Medicinal plants are great sources of phytochemicals, which are abundant in a variety of plants and have few negative effects. They include active chemicals that help the body recover itself and re-establish its natural equilibrium. Traditional Islamic natural products are important sources of therapeutic medications with innovative structures and modes of action for the treatment of a variety of ailments as well as the drug discovery process. The recently reported pharmacologically and therapeutically based medicinal plants and their products that are mentioned in Islamic scriptures are presented in this chapter. The current study also emphasizes recent
This work was supported by Cell and Tissue Culture Lab, Department of Biotechnology and Department of Biochemistry, Era University, Lucknow, India.
The authors declare no conflict of interest.
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\\n\\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
\\n\\nDr Alex Lazinica
\\n\\nAlex Lazinica is co-founder and Board member of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his Ph.D. in Robotics at the Vienna University of Technology. There, he worked as a robotics researcher with the university's Intelligent Manufacturing Systems Group, as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and, most importantly, co-founded and built the International Journal of Advanced Robotic Systems, the world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career since it proved to be the pathway to the foundation of IntechOpen with its focus on addressing academic researchers’ needs. Alex personifies many of IntechOpen´s key values, including the commitment to developing mutual trust, openness, and a spirit of entrepreneurialism. Today, his focus is on defining the growth and development strategy for the company.
\\n"}]'},components:[{type:"htmlEditorComponent",content:"Our business values are based on those any scientist applies to their research. We have created a culture of respect and collaboration within a relaxed, friendly and progressive atmosphere, while maintaining academic rigour.
\n\nCo-founded by Alex Lazinica and Vedran Kordic: “We are passionate about the advancement of science. As Ph.D. researchers in Vienna, we found it difficult to access the scholarly research we needed. We created IntechOpen with the specific aim of putting the academic needs of the global research community before the business interests of publishers. Our Team is now a global one and includes highly-renowned scientists and publishers, as well as experts in disseminating your research.”
\n\nBut, one thing we have in common is -- we are all scientists at heart!
\n\nSara Uhac, COO
\n\nSara Uhac was appointed Managing Director of IntechOpen at the beginning of 2014. She directs and controls the company’s operations. Sara joined IntechOpen in 2010 as Head of Journal Publishing, a new strategically underdeveloped department at that time. After obtaining a Master's degree in Media Management, she completed her Ph.D. at the University of Lugano, Switzerland. She holds a BA in Financial Market Management from the Bocconi University in Milan, Italy, where she started her career in the American publishing house Condé Nast and further collaborated with the UK-based publishing company Time Out. Sara was awarded a professional degree in Publishing from Yale University (2012). She is a member of the professional branch association of "Publishers, Designers and Graphic Artists" at the Croatian Chamber of Commerce.
\n\nAdrian Assad De Marco
\n\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
\n\nDr Alex Lazinica
\n\nAlex Lazinica is co-founder and Board member of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his Ph.D. in Robotics at the Vienna University of Technology. There, he worked as a robotics researcher with the university's Intelligent Manufacturing Systems Group, as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and, most importantly, co-founded and built the International Journal of Advanced Robotic Systems, the world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career since it proved to be the pathway to the foundation of IntechOpen with its focus on addressing academic researchers’ needs. Alex personifies many of IntechOpen´s key values, including the commitment to developing mutual trust, openness, and a spirit of entrepreneurialism. Today, his focus is on defining the growth and development strategy for the company.
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In mechanics of swimming, the reduction of forces, which oppose to the swimmers advancement, plays a very important part in the improvement of the performances. As a consequence, the performance improvement requires a better understanding of the structure of the fluid flow around swimmers and a good knowledge of the pressure fields and wall shear stress encountered to minimize them. This chapter will focus on computational fluid dynamics (CFD) procedures and results for this practical implication in swimming and will aim at highlighting details on numerical schemes, validations, and results showing the way CFD can be used as a powerful tool in swimming understanding.",book:{id:"4690",slug:"mass-transfer-advancement-in-process-modelling",title:"Mass Transfer",fullTitle:"Mass Transfer - Advancement in Process Modelling"},signatures:"Ahlem Arfaoui and Guillaume Polidori",authors:[{id:"55942",title:"Dr.",name:"Ahlem",middleName:null,surname:"Arfaoui",slug:"ahlem-arfaoui",fullName:"Ahlem Arfaoui"}]},{id:"48887",title:"Mass Transfer in Multiphase Systems",slug:"mass-transfer-in-multiphase-systems",totalDownloads:10430,totalCrossrefCites:7,totalDimensionsCites:10,abstract:"Mass transfer in reactive and non-reactive multiphase systems is of vital importance in chemical, petrochemical, and biological engineering applications. In this chapter, theories and models of mass transfer in gas-liquid, gas-solid and gas-liquid-solid systems with and without chemical reactions are briefly reviewed. Literature data on the mass transfer characteristics in multiphase reactors over the last two decades with applications to the Fischer-Tropsch (F-T) synthesis are summarized. Moreover, the F-T reactions are described and an overview of the use of Slurry Bubble Column Reactors (SBCRs) and Multitubular Fixed Bed Reactors (MTFBRs) for low temperature F-T (LTFT) synthesis are discussed. The important factors affecting the hydrodynamic (gas holdup, bubble size/distribution) and mass transfer parameters (volumetric mass transfer coefficients) in SBCRs for F-T synthesis, including operating conditions, gas-liquid-solid properties, reactor geometry and internals as well as gas distributors are also discussed. The discussion reveals that the performance of the LTFT SBCR operating in the churn-turbulent flow regime is controlled by the resistance in the liquid-side film and/or the F-T reaction kinetics depending on the operating conditions prevailing in the reactor. Also, there is a great need to understand the behavior and quantify the hydrodynamics and mass transfer in SBCRs operating with syngas (H2 + CO) and F-T reactor wax in the presence of active catalyst (iron or cobalt) under typical F-T synthesis conditions in a large SBCR with an inside diameter ≥0.15m.",book:{id:"4690",slug:"mass-transfer-advancement-in-process-modelling",title:"Mass Transfer",fullTitle:"Mass Transfer - Advancement in Process Modelling"},signatures:"Badie I. Morsi and Omar M. Basha",authors:[{id:"174420",title:"Prof.",name:"Badie",middleName:"I.",surname:"Morsi",slug:"badie-morsi",fullName:"Badie Morsi"},{id:"174770",title:"Dr.",name:"Omar M.",middleName:null,surname:"Basha",slug:"omar-m.-basha",fullName:"Omar M. 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Those processes include, but are not limited to, (1) ozonation (gas–liquid process), (2) ion exchange (liquid–solid process), (3) biological activated carbon (liquid–solid process), (4) chlorination (gas–liquid process), and (5) carbonation (gas–liquid–solid process).",book:{id:"4690",slug:"mass-transfer-advancement-in-process-modelling",title:"Mass Transfer",fullTitle:"Mass Transfer - Advancement in Process Modelling"},signatures:"Pen-Chi Chiang and Shu-Yuan Pan",authors:[{id:"174898",title:"Prof.",name:"Pen-Chi",middleName:null,surname:"Chiang",slug:"pen-chi-chiang",fullName:"Pen-Chi Chiang"},{id:"174899",title:"Mr.",name:"Shu-Yuan",middleName:null,surname:"Pan",slug:"shu-yuan-pan",fullName:"Shu-Yuan Pan"}]},{id:"49107",title:"Mass Transfer Mechanisms and Transport Resistances in Membrane Separation Process",slug:"mass-transfer-mechanisms-and-transport-resistances-in-membrane-separation-process",totalDownloads:3919,totalCrossrefCites:4,totalDimensionsCites:10,abstract:"One of the major obstacles preventing a more widespread application of membrane technology is the fact that the filtration performance inevitably decreases with filtration time. 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Investigations of the mechanisms of mass transfer in low and high pressure membranes, analyses of diffusion mechanisms in the membrane pore together with identifications of transport resistances resulting from membrane fouling will allow for a comprehensive understanding and in-depth knowledge of the fouling phenomenon and applicable mass transfer mechanisms.",book:{id:"4690",slug:"mass-transfer-advancement-in-process-modelling",title:"Mass Transfer",fullTitle:"Mass Transfer - Advancement in Process Modelling"},signatures:"Amira Abdelrasoul, Huu Doan, Ali Lohi and Chil-Hung Cheng",authors:[{id:"47402",title:"Dr.",name:"Huu",middleName:null,surname:"Doan",slug:"huu-doan",fullName:"Huu Doan"},{id:"47406",title:"Prof.",name:"Ali",middleName:null,surname:"Lohi",slug:"ali-lohi",fullName:"Ali Lohi"},{id:"151521",title:"Dr.",name:"Amira",middleName:null,surname:"Abdelrasoul",slug:"amira-abdelrasoul",fullName:"Amira 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He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. 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He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. 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He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. 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