Characterization of different samples studied.
\\n\\n
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"6380",leadTitle:null,fullTitle:"Cytotoxicity",title:"Cytotoxicity",subtitle:null,reviewType:"peer-reviewed",abstract:"The book Cytotoxicity is aimed to be an essential reading to all medical students, biologists, biochemists and professionals involved in the field of toxicology. This book is a useful and ideal guide for novice researchers interested in learning research methods to study cytotoxic bioactive compounds. The parts of this book describe the replacement and different applications of the cytotoxic agents. All chapters are written by paramount experts in cytotoxicity research. This will hopefully stimulate more research initiatives, funding, and critical insight into the already increasing demand for cytotoxicity researches that have been evidenced worldwide.",isbn:"978-1-78923-431-2",printIsbn:"978-1-78923-430-5",pdfIsbn:"978-1-83881-443-4",doi:"10.5772/intechopen.69919",price:119,priceEur:129,priceUsd:155,slug:"cytotoxicity",numberOfPages:278,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"60d61573c9a66207b8bc54613cac5716",bookSignature:"Tülay Aşkin Çelik",publishedDate:"July 25th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6380.jpg",numberOfDownloads:23078,numberOfWosCitations:40,numberOfCrossrefCitations:35,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:69,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:144,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 14th 2017",dateEndSecondStepPublish:"July 5th 2017",dateEndThirdStepPublish:"October 1st 2017",dateEndFourthStepPublish:"December 30th 2017",dateEndFifthStepPublish:"February 28th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"74041",title:"Dr.",name:"Tulay",middleName:null,surname:"Askin Celik",slug:"tulay-askin-celik",fullName:"Tulay Askin Celik",profilePictureURL:"https://mts.intechopen.com/storage/users/74041/images/system/74041.png",biography:"Dr. Tülay AŞKIN ÇELİK gained her PhD from Fırat University, Art and Science Faculty, Department of Biology, Elazığ/TURKEY. Presently she is an Associate Professor at Aydın Adnan Menderes University, Art and Science Faculty, Department of Biology, Aydın/TURKEY in the field of genetics. She has been a referee for more than 25 international scientific journals and she worked as a researcher and project manager in 13 projects. She is a referent for issues related to the fields of genetic toxicology and anticancer and antioxidant plants. In 2008, she became a member of the European Association for Cancer Research (EACR) and Molecular Cancer Research Association (MOKAD) and in 2018, she became a member of the Medical Biology and Genetics Association (TBGDER). Currently, her scientific interests include bioactive phytochemicals and plant extracts on their cytogenetic and gentotoxic effects on chromosomes and cancer cells and in vivo /in vitro biological activities. Furthermore, she is also investigating the genotoxic and cytotoxic effects of environmental pollutants such as pesticides. She has authored one book and two book chapters in reputed books published by IntechOpen Access Publisher.",institutionString:"Aydın Adnan Menderes University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Adnan Menderes University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1208",title:"Medical Toxicology",slug:"medical-toxicology"}],chapters:[{id:"61438",title:"Introductory Chapter: Cytotoxicity",doi:"10.5772/intechopen.77244",slug:"introductory-chapter-cytotoxicity",totalDownloads:1378,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Tülay Aşkin Çelik",downloadPdfUrl:"/chapter/pdf-download/61438",previewPdfUrl:"/chapter/pdf-preview/61438",authors:[{id:"74041",title:"Dr.",name:"Tulay",surname:"Askin Celik",slug:"tulay-askin-celik",fullName:"Tulay Askin Celik"}],corrections:null},{id:"57702",title:"Cytotoxicity Caused by Asbestos Fibers and Acquisition of Resistance by Continuous Exposure in Human T Cells",doi:"10.5772/intechopen.72064",slug:"cytotoxicity-caused-by-asbestos-fibers-and-acquisition-of-resistance-by-continuous-exposure-in-human",totalDownloads:1007,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The cytotoxic effects of asbestos fibers on human T cells and the acquisition of resistance against asbestos-induced apoptosis have been studied. These analyses are based on the establishment of a continuous and relatively low-dose exposure model of human immune cells exposed to asbestos that resembles actual exposure in the human body. The MT-2 T cell line was selected as the candidate for the investigations. A transient and high-dose exposure to chrysotile resulted in apoptosis with production of reactive oxygen species (ROS) and activation of the mitochondrial apoptotic pathway. However, sublines continuously exposed to low dose of asbestos exhibited resistance to asbestos-induced apoptosis. The mechanism of resistance acquisition involved excess production of IL-10, activation of STAT3, and enhanced expression of Bcl-2 located downstream of STAT3. These changes were also found in a subline continuously exposed to crocidolite. Furthermore, sublines showed a marked decrease in the expression of forkhead box O1 (FoxO1) transcription factor. FoxO1 is known to regulate apoptosis and various other cellular processes. Regarding apoptosis, sublines continuously exposed to asbestos showed reduction of FoxP1-driven proapoptotic genes. This pathway is also considered one of the mechanisms that result in resistance to asbestos-induced apoptosis in sublines. These sublines also exhibited several characteristics suggesting reduction of antitumor immunity.",signatures:"Hidenori Matsuzaki, Suni Lee, Naoko Kumagai-Takei, Yu Min,\nNagisa Sada, Kei Yoshitome, Yasumitsu Nishimura, Megumi Maeda\nand Takemi Otsuki",downloadPdfUrl:"/chapter/pdf-download/57702",previewPdfUrl:"/chapter/pdf-preview/57702",authors:[{id:"34101",title:"Prof.",name:"Takemi",surname:"Otsuki",slug:"takemi-otsuki",fullName:"Takemi Otsuki"},{id:"48627",title:"Dr.",name:"Naoko",surname:"Kumagai-Takei",slug:"naoko-kumagai-takei",fullName:"Naoko Kumagai-Takei"},{id:"48631",title:"Dr.",name:"Yasumitsu",surname:"Nishimura",slug:"yasumitsu-nishimura",fullName:"Yasumitsu Nishimura"},{id:"104893",title:"Dr.",name:"Suni",surname:"Lee",slug:"suni-lee",fullName:"Suni Lee"},{id:"104894",title:"Dr.",name:"Hidenori",surname:"Matsuzaki",slug:"hidenori-matsuzaki",fullName:"Hidenori Matsuzaki"},{id:"219725",title:"Dr.",name:"Kei",surname:"Yoshitome",slug:"kei-yoshitome",fullName:"Kei Yoshitome"},{id:"222581",title:"MSc.",name:"Yu",surname:"Min",slug:"yu-min",fullName:"Yu Min"},{id:"222582",title:"Dr.",name:"Nagisa",surname:"Sada",slug:"nagisa-sada",fullName:"Nagisa Sada"},{id:"222583",title:"Prof.",name:"Megumi",surname:"Maeda",slug:"megumi-maeda",fullName:"Megumi Maeda"}],corrections:null},{id:"58055",title:"The Cytotoxic, Antimicrobial and Anticancer Properties of the Antimicrobial Peptide Nisin Z Alone and in Combination with Conventional Treatments",doi:"10.5772/intechopen.71927",slug:"the-cytotoxic-antimicrobial-and-anticancer-properties-of-the-antimicrobial-peptide-nisin-z-alone-and",totalDownloads:7302,totalCrossrefCites:7,totalDimensionsCites:11,hasAltmetrics:0,abstract:"Nisin is an antimicrobial peptide commonly used as a food preservative since 1969. This peptide has potent antimicrobial activity against several Gram-positive bacterial strains, including clinically important and resistant pathogens. The combination of nisin with conventional antibiotics has been shown to improve the antimicrobial activity of these antibiotic agents. Apart from the antimicrobial properties of nisin, this AMP also displays promising anticancer potential towards several types of malignancies. The nisin Z variant is able to induce selective cytotoxicity in melanoma cells compared to non-malignant cells. It was shown that nisin Z disrupts the cell membrane integrity of melanoma cells and that cytotoxicity is likely due to the activation of an apoptotic pathway. In addition, when used in combination with the conventional chemotherapeutic agents, nisin Z has the potential to enhance the cytotoxicity of these chemotherapeutic agents against cultured melanoma cells. Nisin Z has great potential for clinical application considering its low cytotoxicity to non-malignant cells and its effectiveness against Gram-positive bacterial strains and certain cancers.",signatures:"Angélique Lewies, Lissinda H. Du Plessis and Johannes F. Wentzel",downloadPdfUrl:"/chapter/pdf-download/58055",previewPdfUrl:"/chapter/pdf-preview/58055",authors:[{id:"214707",title:"Dr.",name:"Johannes",surname:"Wentzel",slug:"johannes-wentzel",fullName:"Johannes Wentzel"},{id:"216091",title:"Dr.",name:"Angélique",surname:"Lewies",slug:"angelique-lewies",fullName:"Angélique Lewies"},{id:"216092",title:"Prof.",name:"Lissinda",surname:"Du Plessis",slug:"lissinda-du-plessis",fullName:"Lissinda Du Plessis"}],corrections:null},{id:"58788",title:"Cytotoxic Colchicine Alkaloids: From Plants to Drugs",doi:"10.5772/intechopen.72622",slug:"cytotoxic-colchicine-alkaloids-from-plants-to-drugs",totalDownloads:1467,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Plants produce and store many organic compounds like amino acids, proteins, carbohydrates, fats, and alkaloids, which are usually treated as secondary metabolites. Many alkaloids are biologically active for humans. For thousand years, extracts from plants containing alkaloids had medicinal use as drugs and they owe their powerful effects thanks to presence of alkaloids. Alkaloids have anti-inflammatory, antibacterial, analgesic, local anesthetic, hypnotic, psychotropic, antimitotic, and antitumor activity. Nowadays, alkaloids from plants are still of great interest to organic chemists, pharmacologists, biologists, biochemists, and pharmacists. Plants of Liliaceae family contain colchicine as the main alkaloid, which has cytotoxic activity. Colchicine has limited pharmacological application because of its toxicity, but many derivatives have been synthesized and their cytotoxic activity and tubulin-binding properties have been tested. Many of the synthetic derivatives showed good cytotoxic activity.",signatures:"Joanna Kurek",downloadPdfUrl:"/chapter/pdf-download/58788",previewPdfUrl:"/chapter/pdf-preview/58788",authors:[{id:"214632",title:"Dr.",name:"Joanna",surname:"Kurek",slug:"joanna-kurek",fullName:"Joanna Kurek"}],corrections:null},{id:"58539",title:"Natural Products as Cytotoxic Agents in Chemotherapy against Cancer",doi:"10.5772/intechopen.72744",slug:"natural-products-as-cytotoxic-agents-in-chemotherapy-against-cancer",totalDownloads:1526,totalCrossrefCites:7,totalDimensionsCites:10,hasAltmetrics:0,abstract:"Nature continues to produce a great wealth of natural molecules endowed with cytotoxic activity toward a large panel of tumor cells. Some of these molecules are used in chemotherapy, and others have shown great anti-tumor and anti-metastatic potential in preclinical trials. This review discusses some examples of these molecules that have been studied in our laboratory and others. We report a differential cytotoxic activity of some monoterpenes (carvacrol, tymol, carveol, carvone, and isopulegol) against a panel of tumor cell lines. The carvacrol was the most cytotoxic molecule both in vitro and in vivo as demonstrated by preclinical studies using the DBA2/P815 mice model. On the other hand, polyphenols were also studied with respect to their cytotoxic effects. Interestingly, these compounds showed a prominent cytotoxic activity toward a panel of cancer cells with differential molecular mechanisms. In addition, we report a very strong antitumor efficacy of artemisinin, a sesquiterpen lactone from Artemisia annua, together with an antimetastatic potential as demonstrated by preclinical experiments. Furthermore, some of the molecular mechanisms involved in these effects are described.",signatures:"Abdelmajid Zyad, Inass Leouifoudi, Mounir Tilaoui, Hassan Ait\nMouse, Mouna Khouchani and Abdeslam Jaafari",downloadPdfUrl:"/chapter/pdf-download/58539",previewPdfUrl:"/chapter/pdf-preview/58539",authors:[{id:"187827",title:"Dr.",name:"Inass",surname:"Leouifoudi",slug:"inass-leouifoudi",fullName:"Inass Leouifoudi"},{id:"204146",title:"Prof.",name:"Abdelmajid",surname:"Zyad",slug:"abdelmajid-zyad",fullName:"Abdelmajid Zyad"},{id:"216446",title:"Prof.",name:"Hassan",surname:"Ait Mouse",slug:"hassan-ait-mouse",fullName:"Hassan Ait Mouse"},{id:"216447",title:"Prof.",name:"Mouna",surname:"Khouchani",slug:"mouna-khouchani",fullName:"Mouna Khouchani"}],corrections:null},{id:"58323",title:"Cytotoxicity and Apoptosis Induction by Coumarins in CLL",doi:"10.5772/intechopen.72446",slug:"cytotoxicity-and-apoptosis-induction-by-coumarins-in-cll",totalDownloads:1186,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Chronic lymphocytic leukemia (CLL) is one of the leukemia types. Leukemia is cancer of the body's blood-forming cells. Cancer is a disease that is often characterized by too little apoptosis and uncontrolled duplicate of body cells. Apoptosis, or programmed cell death, is a normal component of the development and health of multicellular organisms. Cells die in response to a variety of stimuli during apoptosis. During cancer, pathophysiology apoptosis of the cancerous cells is disrupted, so one of the strategies for cancer chemotherapy is inducing apoptosis in cancerous cells. Myeloid cell leukemia type 1 (Mcl-1) is one of the antiapoptotic Bcl-2 family proteins. It has been shown that the expression of Mcl-1 in CLL is significantly associated with a failure to achieve complete remission following cytotoxic therapy, so regulation of Mcl-1 expression by coumarins could be one of the mechanisms of CLL chemotherapy. Coumarins consist of a large class of phenolic substances found in plants. Different pharmacologic effects of coumarins were reported. One of these effects is cytotoxicity and apoptosis induction in cancerous cells by coumarins. In this chapter, the cytotoxic activity of coumarins and their role in Mcl-1 regulation are discussed.",signatures:"Omid Gholami",downloadPdfUrl:"/chapter/pdf-download/58323",previewPdfUrl:"/chapter/pdf-preview/58323",authors:[{id:"214865",title:"Dr.",name:"Omid",surname:"Gholami",slug:"omid-gholami",fullName:"Omid Gholami"}],corrections:null},{id:"58914",title:"Cyto(Geno)Toxic Endpoints Assessed via Cell Cycle Bioassays in Plant Models",doi:"10.5772/intechopen.72997",slug:"cyto-geno-toxic-endpoints-assessed-via-cell-cycle-bioassays-in-plant-models",totalDownloads:1041,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Environmental pollution is a matter of great concern. Therefore, researches that aim to access the risk of toxicity of these potential pollutants are welcome in the scientific community. The most common strategy to detect toxic agents is through chemical analysis. However, in the last years, the biological assays are often important for risk assessments. Among the bioassays using living organisms to detect toxicity of a compound, plant models have been highlighted as it is easy to be conducted, has low cost, high sensitivity and presents good correlation with other test systems, including mammals. Besides, it is in accordance with the Toxicology Guidelines for the twenty-first century, which claims for bioassays that could substitute the ones that use animals as models. At cellular level, the cytotoxicity, genotoxicity, and mutagenicity are the parameters determined by the endpoints as mitotic index, DNA fragmentation, induction of cell death, and malfunction of cellular structures leading to chromosome and cell cycle alterations. Each of these endpoints will be presented in details in this chapter.",signatures:"Larissa Fonseca Andrade Vieira and Graciele Lurdes Silveira",downloadPdfUrl:"/chapter/pdf-download/58914",previewPdfUrl:"/chapter/pdf-preview/58914",authors:[{id:"215258",title:"Prof.",name:"Larissa",surname:"Fonseca Andrade Vieira",slug:"larissa-fonseca-andrade-vieira",fullName:"Larissa Fonseca Andrade Vieira"},{id:"215260",title:"M.Sc.",name:"Graciele",surname:"Silveira",slug:"graciele-silveira",fullName:"Graciele Silveira"}],corrections:null},{id:"58235",title:"Role of Cytotoxicity Experiments in Pharmaceutical Development",doi:"10.5772/intechopen.72539",slug:"role-of-cytotoxicity-experiments-in-pharmaceutical-development",totalDownloads:1936,totalCrossrefCites:7,totalDimensionsCites:19,hasAltmetrics:0,abstract:"Through the twentieth century, the road from synthetizing a new drug molecule to become an actual product got longer than ever before. Cytotoxicity assays are a quick way to assess a certain chemical compound’s effects on a given human cell line. The most well-known techniques are the MTT- and the LDH-assays. These tests are cheap, easy to execute, but not very precise and dependent on various environmental factors and also, they show no detail about the time-dependency of the toxic effect. Cytotoxicity experiments are a crucial part of a modern pharmaceutical development process. They are a cheap and safe way to get vital information about a new molecule’s biological attributes focusing on its basic tolerability. These studies not only save human lives and test animals, but they save the time and resources to be spared on a test molecule which is a complete failure having no in vitro safety.",signatures:"Ildikó Bácskay, Dániel Nemes, Ferenc Fenyvesi, Judit Váradi, Gábor\nVasvári, Pálma Fehér, Miklós Vecsernyés and Zoltán Ujhelyi",downloadPdfUrl:"/chapter/pdf-download/58235",previewPdfUrl:"/chapter/pdf-preview/58235",authors:[{id:"215449",title:"Dr.",name:"Ildikó",surname:"Bácskay",slug:"ildiko-bacskay",fullName:"Ildikó Bácskay"},{id:"215453",title:"Dr.",name:"Dániel",surname:"Nemes",slug:"daniel-nemes",fullName:"Dániel Nemes"},{id:"215454",title:"Dr.",name:"Zoltán",surname:"Ujhelyi",slug:"zoltan-ujhelyi",fullName:"Zoltán Ujhelyi"},{id:"215456",title:"Dr.",name:"Ferenc",surname:"Fenyvesi",slug:"ferenc-fenyvesi",fullName:"Ferenc Fenyvesi"},{id:"215457",title:"Dr.",name:"Judit",surname:"Váradi",slug:"judit-varadi",fullName:"Judit Váradi"},{id:"215458",title:"Dr.",name:"Gábor",surname:"Vasvári",slug:"gabor-vasvari",fullName:"Gábor Vasvári"},{id:"215459",title:"Dr.",name:"Pálma",surname:"Fehér",slug:"palma-feher",fullName:"Pálma Fehér"},{id:"215460",title:"Dr.",name:"Miklós",surname:"Vecsernyés",slug:"miklos-vecsernyes",fullName:"Miklós Vecsernyés"}],corrections:null},{id:"61672",title:"Biocompatibility of Doped Semiconductors Nanocrystals and Nanocomposites",doi:"10.5772/intechopen.77197",slug:"biocompatibility-of-doped-semiconductors-nanocrystals-and-nanocomposites",totalDownloads:1137,totalCrossrefCites:7,totalDimensionsCites:10,hasAltmetrics:0,abstract:"Exposure of humans and environment to nanocrystals are inevitable, and nanotoxicological analyses are a requirement. The wide variety of nanocrystals with different applications is increasing, and characterization of their effects after exposure includes their potential toxicity and uses. This review summarizes the characterization of doped nanocrystals and nanocomposites, Ca-doped ZnO, Ag- and Eu-doped ZnO and Ni-doped ZnO NCs, their biocompatibility and applications. This review uncovers how these nanocrystals present desirable biocompatible properties, which can be useful as antitumoral and antimicrobial inducing agents, which differ markedly from toxic properties observed in other general nanocrystals.",signatures:"Anielle Christine Almeida Silva, Mariana Alves Pereira Zóia, Lucas Ian Veloso Correia,\nFernanda Van Petten Vasconcelos Azevedo, Aline Teodoro de\nPaula, Larissa Prado Maia, Layara Santana de Carvalho, Loyna\nNobile Carvalho, Maria Paula Camargo Costa, Layssa Carrilho\nGiaretta, Renata Santos Rodrigues, Veridiana de Melo Ávila, Luiz\nRicardo Goulart and Noelio Oliveira Dantas",downloadPdfUrl:"/chapter/pdf-download/61672",previewPdfUrl:"/chapter/pdf-preview/61672",authors:[{id:"13001",title:"Dr.",name:"Noelio",surname:"Oliveira Dantas",slug:"noelio-oliveira-dantas",fullName:"Noelio Oliveira Dantas"},{id:"217672",title:"Prof.",name:"Anielle",surname:"Silva",slug:"anielle-silva",fullName:"Anielle Silva"},{id:"227086",title:"MSc.",name:"Fernanda",surname:"Van Petten Vasconcelos Azevedo",slug:"fernanda-van-petten-vasconcelos-azevedo",fullName:"Fernanda Van Petten Vasconcelos Azevedo"},{id:"227087",title:"MSc.",name:"Mariana",surname:"Alves Pereira Zóia",slug:"mariana-alves-pereira-zoia",fullName:"Mariana Alves Pereira Zóia"},{id:"227089",title:"BSc.",name:"Lucas Ian",surname:"Veloso Correia",slug:"lucas-ian-veloso-correia",fullName:"Lucas Ian Veloso Correia"},{id:"227090",title:"Dr.",name:"Aline",surname:"Teodoro De Paula",slug:"aline-teodoro-de-paula",fullName:"Aline Teodoro De Paula"},{id:"227099",title:"Prof.",name:"Renata",surname:"Santos Rodrigues",slug:"renata-santos-rodrigues",fullName:"Renata Santos Rodrigues"},{id:"227100",title:"Prof.",name:"Veridiana",surname:"De Melo Ávila",slug:"veridiana-de-melo-avila",fullName:"Veridiana De Melo Ávila"},{id:"227101",title:"Prof.",name:"Luiz Ricardo",surname:"Goulart",slug:"luiz-ricardo-goulart",fullName:"Luiz Ricardo Goulart"},{id:"227368",title:"Ms.",name:"Maria Paula",surname:"Camargo Costa",slug:"maria-paula-camargo-costa",fullName:"Maria Paula Camargo Costa"},{id:"227369",title:"Ms.",name:"Layssa",surname:"Carrilho Giaretta",slug:"layssa-carrilho-giaretta",fullName:"Layssa Carrilho Giaretta"}],corrections:null},{id:"57853",title:"Toxicity of Titanate Nanosheets on Human Immune Cells",doi:"10.5772/intechopen.72234",slug:"toxicity-of-titanate-nanosheets-on-human-immune-cells",totalDownloads:969,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Titanium oxide is regarded as a bio-inert material, but studies concerning the toxic effects of titanium dioxide (TiO2), particularly nano-scaled TiO2 particles, have been accumulating that indicate nano-scaled TiO2 particles show more harm and cause greater alteration of immune functions compared with large particles. Inorganic nanosheets have been the focus of increasing interest because of their ultrathin structure, as well as diversity of compounds and structures leading to various functions. Oxide nanosheets are included in the group comprising inorganic nanosheets, and titanate nanosheets (TiNSs) represent a form of oxide nanosheets. We therefore examined the toxicity of nano-scaled 2D materials of TiNSs on human immune cells. Our study revealed that TiNSs have the potential to cause harm through caspase-dependent apoptosis of human peripheral blood mononuclear cells (PBMCs) to the same degree as asbestos. Furthermore, isolated monocytes developed marked vacuoles prior to cell death upon exposure to TiNSs, which were found in the vacuoles and indicated engulfment of TiNSs. A consideration of these findings with the co-localization of vacuoles with endocytosed fluorescence-labeled dextran indicates that TiNSs entered the endosomal pathway, leading to the formation of vacuoles in monocytes and subsequent cell death. TiNSs might therefore affect immune functions through interference of endo-lysosomal functions.",signatures:"Yasumitsu Nishimura, Daisuke Yoshioka, Naoko Kumagai-Takei,\nSuni Lee, Hidenori Matsuzaki, Kei Yoshitome and Takemi Otsuki",downloadPdfUrl:"/chapter/pdf-download/57853",previewPdfUrl:"/chapter/pdf-preview/57853",authors:[{id:"48631",title:"Dr.",name:"Yasumitsu",surname:"Nishimura",slug:"yasumitsu-nishimura",fullName:"Yasumitsu Nishimura"}],corrections:null},{id:"58365",title:"General Cytotoxicity and Its Application in Nanomaterial Analysis",doi:"10.5772/intechopen.72578",slug:"general-cytotoxicity-and-its-application-in-nanomaterial-analysis",totalDownloads:1609,totalCrossrefCites:3,totalDimensionsCites:6,hasAltmetrics:0,abstract:"The recent increasing interest in the use of different nanoparticles in biological and medical applications encouraged scientists to analyse their potential impact on biological systems. The biocompatibility analyses of novel materials for medical applications are conducted using quantitative and qualitative techniques collected by the International Standards Organization (ISO). The well-known assays, such as tetrazolium-based assays used for mitochondrial function monitoring, LDH for membrane permeability determination and neutral red uptake (NRU) describing lysosome function, need to be optimised due to specific properties of wide range of nanomaterials. Physicochemical properties of nanoparticles (NPs) such as size, composition, concentration, shape and surface (e.g., charge, coating, aspect ratio), as well as the cell type play a crucial role in determining the nanomaterial toxicity (also uptake pathway(s) of NPs). Different nanomaterials exhibit different cytotoxicity from relatively non-toxic hexagonal boron nitride to rutile TiO2 NPs that induce oxidative DNA damage in the absence of UV light. Finally, the results of the nanomedical analysis can be enriched by holographic microscopy that gives valuable information about the doubling time (DT), cell segmentation, track cell movement and changes in cell morphology. The results can be also completed by phenotype microarrays (PMs) and atomic force microscopy (AFM) techniques that fulfil experimental data.",signatures:"Magdalena Jedrzejczak-Silicka and Ewa Mijowska",downloadPdfUrl:"/chapter/pdf-download/58365",previewPdfUrl:"/chapter/pdf-preview/58365",authors:[{id:"186478",title:"Dr.",name:"Magdalena",surname:"Jedrzejczak-Silicka",slug:"magdalena-jedrzejczak-silicka",fullName:"Magdalena Jedrzejczak-Silicka"},{id:"231014",title:"Prof.",name:"Ewa",surname:"Mijowska",slug:"ewa-mijowska",fullName:"Ewa Mijowska"}],corrections:null},{id:"61587",title:"Review of In vitro Toxicity of Nanoparticles and Nanorods: Part 1",doi:"10.5772/intechopen.76365",slug:"review-of-in-vitro-toxicity-of-nanoparticles-and-nanorods-part-1",totalDownloads:1142,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The specific use of engineered nanostructures in biomedical applications has become very attractive, due to their ability to interface and target specific cells and tissues to execute their functions. 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From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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In this book, remarkable experts in anthropology have dedicated illustrative chapters on different sectors of the discipline. Each chapter presents a case study and the applications of the most interesting specific techniques. Each chapter offers a widespread diversity of topics covering the broader subjects of biological anthropology, providing an extensive sample of the applications of several methods in anthropology.
This volume intends to provide to the reader an overview of the contemporary state-of-the-art in some different aspects of biological anthropology, in specific in bioarchaeology and paleopathology and forensic anthropology. It could be an important resource for the scientific community that belongs to this discipline, such as evolutionary biologists, ecologists, medical researchers or a starting point for exploring these practices by students.
Bioarchaeology is the study of human and animal remains. The term was first proposed by Grahame Clark to designate the studies of animal bones from archaeological sites [2]. Since the end of the ‘70s the term bioarchaeology is used within the meaning of human osteoarchaeology. The bioarcheological investigation is focused on the study of human variation and evolution in earlier society, using specific methods and techniques in osteological analysis from the mortuary context in archaeological records [3]. Skeletal and dental remains offer an important source of biological information offer for interpreting lifeway of past peoples. Skeletons can provide insight into living conditions, health status, disease, dietary history, lifestyle, violence, trauma, ancestry and demography [4] from individual to population perspective.
Bioarchaeology manifest itself the strict connection between culture and biology [5] and, as Goodman said, one would not exist without the other [6]. This integrative and interdisciplinary research mixed traditional macroscopic skeletal analysis [7, 8] (for estimating biological profile i.e. age, sex, ancestry, stature), bone chemistry [4, 9], ancient DNA [10] with grave contexts, local legends, sagas and other historical information [11] with which to address questions about past populations. In its book “Skeletons in our closet”, C.S. Larsen said: “
Over the past few decades, new methods and technological innovation providing remarkable strategies to exploring past human relationship and activities [13]. For example, computational and statistical methods [14], computer-based methodologies (e.g. 3D face reconstruction) [15] or analytical procedures for identifying isotopes and biomolecules [13] in biological material excavated in archaeological sites have become very popular in the studies of this discipline. The use isotopic analysis of bones and teeth has exploded over the past few decades to the point where it is now an established tool that is routinely used to investigate questions relating to diet and mobility [16] and for radiocarbon dating, climate and habitat reconstruction [9, 17].
The chapter “Anthropological and paleodietary analysis of human temains: a case study from the teutonic settlement of Torre Alemanna in Puglia (Cerignola, FG, Italy)” illustrates how craniological and craniometric analysis, study of nutritional and occupational stress markers allows to understand the interaction between man and environment, and how we can use this knowledge to reconstruct the
Paleopathology is strictly connected with bioarchaeology. Paleopathology entails the study of ancient human disease [18] from human bones and mummies. The paleopathological investigation provides fundamental understanding concerning the antiquity of some diseases and their dissemination in past human groups [19]. Human lives changed drastically over the last hundred years and these temporal changes in human lifestyles are detectable in the skeletal records. Osteological and biological markers highlight to the paleopathologists the pathological condition of past populations, affected by consistent anatomical alteration like trauma, dental disease, activity or mechanical stress, osteoarthritis, tumours [20, 21, 22, 23]. Paleopathology need a profoundly interdisciplinary endeavour, encompassing aspects of the biomedical science, the humanities, and the social sciences [24]. Understanding ancient diseases is strictly connected with clinical science, with its process of paleopathological problem solving, the practice of differential diagnosis and the construction of diagnostic arguments [25, 26].
Diagnostic criteria can be applied to evaluate inflammation, surgical intervention (e.g. cranial trepanation) or infections of pathogenic microorganisms in the past, like Tuberculosis [27, 28], Leprosy [29, 30], Treponematosis [31], Brucellosis [32].
Paleopathology requires also a consistent biochemistry approach. The use of isotope provides evidence of metabolic disease and nutritional deficiencies, like vitamin deficiencies in a disease like rickets [33], scurvy [34, 35] and pellagra [36].
The chapters “Cranial trepanation: case studies between the IV century BC and VI century in southern Italy” and “Anthropological and palaeopathological study of a skeleton from late Roman Sicily
The study of human remains is not limited only to ancient finds. In recent years
Technological advances represent a key potential for improved capability in scientific identification of human remains recovered in a medicolegal context [39].
In addition to age, sex, stature, ancestry determination is it possible to carry out analysis for facial, dental and soft tissues identification. Scientific progress allowed the application of these technologies in crime context as homicide, mass-fatality disasters, genocide. Forensic anthropologists can thus provide Technical services to medical examiners, like cranial and post-cranial evidence, anatomical and biological profile based on
In recent years DNA analysis, radiographic evaluations of skeletal details, computerized tomography (CT) are becoming increasingly used in the field of forensic anthropology. Also, DNA sequencing, blood genetics, fingerprints provide invaluable assistance in the identification of victims and perpetrators of crimes [41].
The chapter “Forensic anthropology” presented here focus on applied aspects of forensic anthropology analysis and how forensic anthropologist can contribute to an investigation.
Moving from Mirko Grmek naturalistic approach to the history of medicine [42], is possible to link his concept of “pathocenosis” to the evolutionary perspective. In the broad area of study that anthropology covers, a multidisciplinary approach can provide us with a wealth of information on various issues. Biological issues, faced by comparing, for example, how pathologies have coexisted with humans over time, can provide us with useful information. We can therefore study not only how the daily life of
At last, I would like to thank all of the authors for their contribution, encouragement, time and patience. This volume would not be possible without their perseverance. I want to thank all the colleagues and collaborators who have supported that project, spent time exchanging ideas or even just provided general encouragement. I am deeply grateful for all of you.
The world’s oil reserves are not eternal. Exploitation for fuel increases emissions of greenhouse gases that contribute to climate change. Renewable biomass is a promising alternative to petroleum-based products as a source of bio-energy and other bio-products [1], as the chemical value. The condensed Biogas is a type of liquid fuel made from biomass materials. As a kind of new cheap bio-energy, clean, green, bio-oil is considered an attractive option instead of conventional fuel in the aspect of reducing environmental pollution [2].
This study is motivated by a desire for development of natural resources to begin we take as cistus products. The study consisted of pyrolysis byproducts cistus ladanifer [3]. The cistus pyrolysis regenerates solid carbon-rich products (char) and condensable gaseous products (tar) and non-condensable (hydrocarbons). The process of pyrolysis is the newest part of renewable energy, has been set up and provides the benefits of a liquid product—bio-oil—which can be easily stored and transported and used as a fuel, vector energy and a source of chemicals. Bio-oils have been successfully tested in engines, turbines and boilers, and were up graded to high quality hydrocarbon fuels but currently unacceptably energy and financial cost [4].
The slow pyrolysis is often linked to coal production and fast pyrolysis has been linked to the production of bio-oil. The slow pyrolysis of biomass produces a high content of carbon [5]. Pyrolysis safflower seeds
After a series of studies of characterization of the seeds and shells of cistus by the different techniques of analysis, the determination of the percentages in carbon, oxygen, hydrogen, and nitrogen as well as the determination of the percentages in humidity, ash, fixed carbon, and volatile products, by the elementary analysis of the biomass, we give a clear idea on the pyrolysis of the used biomass. The knowledge of the above-mentioned data creates a good ground for the study of the different factors that influence the yield of bio-oil obtained by pyrolysis. In this chapter, we will study three main parameters that are: the effect of temperature, the effect of granulometry, and the effect of the heating speed on the yield of the two biomasses used.
Biomass is the whole of the organic products, plants, and animals used for energy or agronomic purposes. The term biomass covers a very broad field: forestry waste, industrial waste, agricultural waste, the fermentable fraction of household waste and food industries, landfill biogas, or methanization products (sewage sludge, landfills, etc.…). In this chapter, the different experimental campaigns were carried out using two types of biomass:
We took the initiative to study two types of biomass (Figure 1), one with little ash and the other with a lot more ash, in order to compare the different results and to be able to provide solutions for each type of biomass exploited. The main characteristics of the biomasses used are presented below.
(a) Plant with fruit; (b) seeds; (c) seed powder; and (d) plant with flower; (e) shells; and (f) shell powder.
The moisture or water content designated by W of a sample is the ratio between the mass of water contained in the sample to its anhydrous mass, if we use its total mass this:
This ratio will be designated by W.
Moisture is determined by subjecting a sample of known mass to oven drying (103°C) for 24 hours until the mass becomes constant. The humidity can be expressed as a percentage.
Relative to the anhydrous mass:
Or m0: Total wet mass of the sample in (g); and ma: Anhydrous mass in (g).
The cistus seeds and these shells are impregnated samples were incinerated at 600° C, to a constant mass in a muffle furnace.
The ash content, expressed as a percentage, is given by the equation:
Where, mcr: Mass of the empty crucible (g); m1: Mass of the crucible and the ashes (g); and m2: Mass of the crucible and the biomass intake (g).
The volatile matter represents the vapors of organic compounds and gases released by the biomass during pyrolysis, while the carbonaceous matter is the solid residue of carbon that remains after volatilization. Determination of volatile matter and fixed carbon for each sample was performed at 21°C.min−1 under an inert atmosphere for seeds and 40°C.min−1 for shells in a fixed bed pyrolysis reactor.
The volatile matter is determined by the formula:
Where: m0: Initial mass of the sample; ma: Mass of the dry sample (g); mv: Mass of the devolatilized sample (g); mC: Mass of ash (g).
The difference between the mass of the devolatilized sample (mv) and that of the ash (mC) represents the fixed carbon, designated by C. Fixed, whose mass percentage is given by the equation.
The results of the various analyses are summarized in Table 1.
Seeds (%) | Shells (%) | |
---|---|---|
Moisture | 13 | 7.3 |
Ash | 9.6 | 2.94 |
Volatile matter | 69.76 | 74.82 |
Fixed carbon | 7.64 | 14.94 |
Characterization of different samples studied.
The values measured are comparable to the results obtained by the pyrolysis of olive stones [1, 2] and those obtained by the pyrolysis of castor oil [14, 15, 16, 17]. The contents of sulfur and nitrogen obtained by the different samples are low compared to the other references. Table 2 presents the elemental composition of pyrolysis by-products in the literature and the values obtained from different samples in this study.
Literature | C | H | O | N | S |
---|---|---|---|---|---|
Olive Seeds | 47.36 | 6.04 | 45.52 | 0.96 | 0.12 |
Olive Kernel | 49.9 | 6.2 | 43.3 | — | — |
Castor seeds | 59.25 | 7.15 | 29.94 | 3.20 | 0.46 |
Castor shells | 49.8 | 5.3 | 43.9 | 0.9 | 0.1 |
Karanja Seeds [18] | 53.04 | 7.32 | 35.53 | 3.94 | 0.18 |
Cistus Seeds | |||||
Cistus Shells |
Elemental composition of same biomass compared with cistus seeds and shells.
According to the results obtained our biomass presents a significant percentage in C which is higher compared to other biomasses such as olive seed, and castor for example which does not exceed 59%, and for wood and coconut shells it is equal to 53.9 and 57.3% respectively[19]. On the other hand, the other elements like Oxygen, Nitrogen, Hydrogen, and Sulfur are lower than the biomasses quoted in Table 2. These values give the advantage to study the seeds and the shells of cistus for the production of bio-oils with the aim of transforming them into biofuels which are the vectors of actuality.
One introduces 2% of the sample with 98% of KBr then crushes the mixture to prepare pellets. We put the pellet in the support of infrared apparatus we obtain the spectra below.
Fourier transform infrared (FTIR) analysis of the raw material, seeds, and shells of cistus in Figure 2 shows free -OH bonds at 3658.07 cm−1 and broadband of the bound -OH group, =CH2 groups from 2866 to 3078 cm−1, peaks of phosphene from 2280 to 2410 cm−1, C=O bonds of the β-lactams with four centers from 1600 to 1720cm−1, of aliphatic ketones 1705 to1725 cm−1, C=C bonds of aromatics and phenols from 1550 to 1600 cm−1, aromatic amines at 1515 cm−1, C-O bonds of esters from 1210 to 1260 cm−1, P-O-C bonds of phosphene at 1055 cm−1 and from 530 to 580 cm−1 of C-N bonds of nitriles, C-H bonds of mono and di-substituted aromatics from 650 to 900 cm−1 and finally the presence of cyclanes from 415 to 580 cm−1. It can be concluded that the infrared spectroscopy confirms the important percentage of oxygen in the biomass by the presence of oxygenated groups like acids, Esters, Alcohols, Ketones, and Ethers.
FTIR spectrum of cistus shells and seeds.
The calorific values are calculated by a calorimetric bomb Leco501–053 Acetanilide. These values obtained are also compared to other biomasses. The results are given in Table 3.
Material | Calorific Value MJ.kg−1 |
---|---|
Castor seeds [15] | 24.47 |
Castor shells [16] | 18.9 |
Black cumin seeds [20] | 22.46 |
Karanja seeds [21] | 22.38 |
Cistus seeds | |
Cistus shells |
Calorific values of the raw material.
According to the results of the Table 3, the seeds of cistus and their shells present a better calorific value of 25.12 MJ.kg−1 and 23.29 MJ.Kg−1 respectively. To our knowledge it is the highest in comparison with other biomasses cited in the literature and which are presented in Table 3, therefore, the biomass used is a very good source of bio-oil or biofuels of second generation for a sustainable environment and economy.
The experiments were conducted to determine the influence of the pyrolysis temperature at a heating rate varying from 7 to 28°C.min−1 for seeds and from 10 to 70°C.min−1 for shells. The experiments were carried out in an apparatus designed with a cylindrical semi-batch reactor, in the shape of a vessel made of stainless steel, inserted vertically into an electrically heated oven (Figure 3). The temperature is controlled by a PID controller. The biomass sample (seeds or cistus shells) is introduced into the reactor during pyrolysis. The vapors generated from the reactor were condensed in a condenser cooled with chilled water. Figure 3 represents the experimental setup.
Pyrolysis experimental set-up. Description: (1) elevator, (2) vertical tube farnace, (3) biomass sample, (4) pyolysis reactor, (5) temperature controller (PID), (6) water out, (7) condenser, (8) water in, (9) gas release, (10) ice bath, (11) condensate, (12) liquid, and (13) metal support.
After each experiment, the condensed liquid is collected in the cylindrical measuring device. After pyrolysis, the solid residue was collected and weighed. The sample inlet of biomass and charcoal were solid measured by the electro weighing machine balance with an accuracy of ±0.01 g.
The reactor is a fixed bed (Figure 4). The detailed drawings are provided in part (2.3.1). It consists of a 310 AISI47 refractory stainless steel tube with an internal diameter of 60 mm and a total height of 150 mm. The head of the reactor is removable so that the bed can be introduced and then recovered at the end of the experiment. The whole reaction zone, between the diffuser and the gas outlet at the top of the reactor, has a total height of 150 mm. It includes the bubbling bed and the disengagement zone.
Photography of reactor.
To carry out this study we are obliged to fix the other parameters like particle size and heating rate as well as residence time. We introduce 15 g of the cistus seeds into the reactor which is fed with an electric current. The different results will be presented in the following sections. The yields of different pyrolysis products are calculated by the difference between the initial weight and the final weight which is the solid (char) that remains in the reactor. The liquid (Bio-Oil) which is taken in a graduated cylinder and the percentage of gas escaped to the atmosphere were calculated by the following relationship:
In this step the particle size is fixed between 0.3 and 0.6 mm, to determine the effect of temperature. Using the results of the first experiments we have done we have found that the best yields in bio-oils are expected at a temperature equal to 450°C. At this stage we have already determined the main factor which is the temperature, and then it only remains the speed of heating that we vary from 7 to 28°C.min−1. So, we take this conclusion in hand and we begin the study by the variation of the speed of heating from 7 to 28°C.min−1 each time, we calculate the yield of the obtained bio-oil. We deduced that for a heating speed lower than 21°C.min−1 we have yields of bio-oil less than 52.24% the same thing for speeds higher than 21°C.min−1. Finally, we find that the optimal speed for this study is equal to 21°C.min−1.
The diameter of the particles is fixed between 0.3 and 0.6 mm. 15 g of rockrose seeds are introduced into the fixed bed reactor and the temperature is changed between 300 and 500°C. The yields of the products of pyrolysis are calculated by the difference between the initial weight and the final weight that constitutes the solid (char) that remains in the reactor, the liquid (HP) that is taken in a graduated test tube, and the percentage of the gas that has escaped in the atmosphere were calculated by the relation of Eq. (6).
Figure 5 represents the pyrolysis yields of cistus seeds with a heating rate of 21°C.min−1 starting from a temperature of 300°C. The yields of charcoal, pyrolysis oil and gas are quite close. When the temperature increases from 300 to 400°C we observe, on the one hand, an increase of liquid from 34.7 to 51.76%, and on the other hand a slight decrease of coal yield and gas yield down to 18.2%. In the range of 400 to 425°C, the liquid continues to increase along with a decrease in gas yield. At temperatures between 425 and 475°C a plateau of yield for the three (Bio-Oil, solid and gas) was noticed with a maximum yield of liquid at 450°C which is equal to 52.24%. From 475 to 500°C we observe a drop in the yield of solid and liquid in parallel and an increase in the yield of gas.
Yield of pyrolysis products at various pyrolysis temperatures of seeds.
For the sizes that vary between 0.3; 0.4 and 0.5 mm at the same temperature we notice a small variation in the yield of pyrolysates which is equal to 0.2%. For this reason we have taken the particle size between 0.3 and 0.6 mm to complete the study.
Figure 6 shows the effect of heating rate on pyrolysate yields. The liquid and gas yields increase from 43.2 to 52.24% and from 27.60 to 17.51%, respectively when the heating rate is increased from 7 to 21°C.min−1. The increase in liquid yield with increasing heating rate may be due to higher heating rates breaking thermal barriers and mass transfer in the particles. The gas yield also increases with increasing heating rates due to the cracking of pyrolysis vapors at higher heating rates. The solid yield was increased slightly from 29.2 to 30.24 wt% when the heating rate was increased from 7 to 21°C.min−1.
Effect of heating rate on pyrolysis yields of seeds.
The effect of particle size on the yields of pyrolysis products is shown in Figure 7, under the temperature of 450°C and the heating rate equal to 21°C.min−1. Oil yield increased from 38 to 43.07% followed by a slight decrease in solid yield from 33.4 to 32.11 wt% and gas yield decreased from 28.6 to 24.82 wt% when the particle size increased from less than 0.075 to 0.15 mm and from 0.15 to 0.3 mm. And for particle sizes from 0.3 to 0.6 mm, the bio-oil yield follows a progressive increase until the maximum yield of 52.24%.
Yield of pyrolysis products with different particle size seeds.
On the other hand the yield of gas and solid decreases from 24.82 to 17.51% and from 32.11 to 30.24% respectively. For particle sizes from 0.6 to 0.9 mm, the solid yield increases to 35.1%, and the gas and bio-oil yields decrease from 17.51 to 17.3% and from 52.24 to 47.6% respectively. For smaller particle sizes, the yield favors cracking hydrocarbons. The increases in solid yield with increasing particle size for the biomass sample could be due to a greater temperature gradient, within the particles. Thus at some point, the core temperature is lower than the surface temperature, this eventually gives rise to an increase in solid yield.
Figure 8 shows the slow yields of pyrolysis products of cistus shells with the particle size of 2–3 mm at different temperatures from 300 to 500°C. The liquid yields and gas increased 38.53 to 44.6% by weight and 23.64 to 26.49%, respectively, while the solid yield decreased from 47.82 to 28.91% when the pyrolysis temperature is increased from 300 to 400°C.
Yield of pyrolysis products at various pyrolysis temperatures of shells.
In the temperature range of 400 to 450°C, it is observed a small decrease in solid and gas pass yield of 28.91 to 25.18% and from 26.49 to 21.51%, respectively, and the yield of bio-oil follow the increase maximum yield which was 53.31%. The low yield of liquid and low temperature gas is due to the incomplete decomposition of the shell. The decrease in the bio-oil yield and the increase in the gas yield of 47.11 and 28.6% respectively were observed at 500°C could be due to secondary cracking pyrolysis vapor and solid char. Similar results were observed in the study slow pyrolysis fixed bed of
The effect of particle size on products yields was assessed by running pyrolysis experiments with a final temperature of 450°C and heating rate equal to 40°C.min−1. Results are summarized in Figure 9. The lowest oil yield (35%) was obtained using the feedstock of tiniest particles (0.3–0.6 mm), which conversely afforded the maximal amount of gas products (38%) and a charcoal yield equal to 27%. When the particle size was increased to 1–2 mm, the oil yield was incremented to 48%, while both gas (27%) and char (25%) yields decreased.
Yield of pyrolysis products with different particle size shells.
The peak of oil production (yield = 53.31%), in conjunction with a further decline of gas (20%) and char (26.69%) yields, was achieved using 2–3 mm particles. Interestingly, the formation of charcoal (yield = 32.1%) reached a maximum when biggest particles (3–3.5 mm) were used, showing a significant effect of particle size on the performance of carbonization processes. On one hand, the use of smaller particles could promote the cracking of hydrocarbons, and the longer residence time of volatiles in the reactor would lead to the decrease of liquid yield. On the other hand, the increase of biomass particles size could produce a larger temperature gradient within the particles, so that at some point, the core temperature is lower than the surface, which might possibly lead to an increase in solid products yield.
Pyrolysis of cistus shells with particle size from 2 to 3 mm was next performed with a final temperature of 450°C and different heating rates. As shown in Figure 10, both oil and gas yields evenly grew upon increasing the heating rate from 10 to 40°C.min−1, passing from 48.33 and 19.20%, respectively, at 10°C.min−1 to 53.31 and 21.5%, respectively, at 40°C.min−1. The char yield dropped from 32.47 to 25.19%. This change can be ascribed to the shorter residence time and reduced incidence of cracking for pyrolysis vapors, which also account for the increased yield of tar. At 40°C.min−1, the optimal heating rate for the production of oil (yield = 53.31%), the yields of charcoal and gas underwent a further slight reduction. Finally, for heating rates greater than 40°C.min−1, decreased oil yield against increased solid and gas yields due to the fast pyrolysis of cistus seeds were observed.
Effect of heating rate on pyrolysis yields of shells.
The obtained bio-oil is characterized by FTIR spectroscopy to determine the different functional groups existing. Figures 11 and 12 shows the infrared spectrum of the bio-oil of cistus seeds and shells. Tables 4 and 5 represents the results of elemental analysis of the bio-oil and the calorific values.
FTIR spectrum of bio-oil (Cistus seeds).
FTIR spectrum of bio-oil (Cistus shells).
Element | Ultimate analysis (w/w %) | ||||||
---|---|---|---|---|---|---|---|
Cistus seeds [22] | Castor [15] | Sesame [23] | Mustard | Neem | Jatropha | Rapeseed | |
C | 70.5 | 45.19 | 47.47 | 42.52 | 59.17 | 45.92 | |
H | 10.35 | 7.55 | 5.73 | 4.52 | 6.52 | 6.21 | |
N | 5.1 | 7.26 | 6.16 | 1.87 | 0.38 | 6.90 | |
S | NI | 0.72 | 1.74 | 1.30 | NI | 0.88 | |
O | 14.05 | 39.27 | 38.91 | 49.79 | 33.93 | 40.09 | |
H/C | 1.75 | 0.17 | 1.45 | 1.28 | NI | 1.62 | |
O/C | NI | NI | NI | NI | NI | NI | |
HV(MJ/kg) | 36.5 | 19.78 | 20.5 | 18.20 | 13.55 | 19.84 | |
Formula |
Elemental analysis of bio-oil from seeds.
Element | Ultimate analysis (w/w %) | ||||
---|---|---|---|---|---|
Cistus Shells | Castor [16] | Apricol Kernel [11] | Hornbeam (Charme) [24] | Walnut (Noix) [25] | |
C | 74.5 | 64.45 | 66.42 | 59.89 | |
H | 10.76 | 8.24 | 6.93 | 7.33 | |
N | 2.56 | 0.81 | 1.54 | 0.5 | |
S | NI | NI | NI | 0.02 | |
O | 11.78 | 26.50 | 25.11 | 32.26 | |
H/C | 1.76 | 1.53 | 1.24 | 1.74 | |
O/C | 0.12 | NI | NI | NI | |
Calorific Value (MJ/kg) | 35.01 | 27.19 | 30 | 25.01 | |
Formula | NI |
Elemental analysis of bio-oil from shells.
The analysis of the bio-oil of cistus seeds by Fourier Transform Infrared (FTIR) (Figure 11) shows the C-H bonds of cyclobutane in symmetrical and antisymmetrical vibration between (2800–2900 cm−1), the aliphatic ketones (1705–1725 cm−1), the C=C bonds of aromatics and phenols between (1550–1600 cm−1), the C-O bonds of esters between (1210–1260 cm−1), C-OH bonds of primary and secondary alcohols between (1050–1080 cm−1), and between (1110–1220 cm−1), C-N bonds of aromatic amines between (1020–1220 cm−1), C-H bonds of mono and disubstituted aromatics between (650–900 cm−1) and finally the presence of (Z) and (E) isomers of alkenes between (650–750 cm−1) and (950–1010 cm−1).
Bio-oil analysis of cistus shells by oven transformation (FTIR) (Figure 12), shows -OH groups of phenols and acids between at 3352.67 cm−1 and 2622.47 cm−1 respectively, the C=O of acids at 2173.98 cm−1 and aromatic ketones at 1697.75 cm−1, the C ≡ C of alkynes at 2118.51 cm−1, the C=C of alkenes at 1642, 10 cm−1 and, the C-N of amines at 1516.63 cm−1, the C-H of aldehydes at 1370.73 cm−1, the C-N of aromatic amides at 1275.43 cm−1, the C-O of esters and ethers at 1082.50 cm−1, the nitrile groups -NO2 at 930.64 cm−1 and finally the C-H bonds of polycyclic and substituted aromatic groups between 679 and 757.04 cm−1.
The results of Table 5 shows that our bio-oil extracted by fixed bed pyrolysis contains more carbon compared to Apricol, hornbeam and walnut shells, but the percentage of oxygen in the bio-oil is smaller than Apricol, hornbeam and walnut bio-oils. In addition, we observe a total absence of sulfur in our bio-oil. We do not forget that the energetic value of the bio-oil is the highest compared to the bio-oils quoted in the literature and close to that of the oil which varies from 40 to 44 MJ.kg−1 (Table 6).
Samples | Density | Speed limit | A | B | Dyn. Viscosity | Kin. Viscosity |
---|---|---|---|---|---|---|
mg cm−3 | cm.s−1 | cm.s−2 | s−1 | η (mPa.s) | η (mm2.s−1) | |
Bio-oil (seeds) | 897.6 | 1.0182 | 6.5487 | 6.4317 | 3.8693 | 4.3107 |
Bio-oil (shells) | 881.3 | 1.0521 | 6.6078 | 6.2806 | 3.7784 | 4.2871 |
Commercial Diesel 1 | 829.9 | 1.2109 | 6.7947 | 5.6113 | 3.3758 | 4.0677 |
Commercial Diesel 2 | 829.4 | 1.2268 | 6.7965 | 5.5400 | 3.3329 | 4.0185 |
Commercial Diesel 3 | 830.3 | 1.2475 | 6.7931 | 5.4454 | 3.2760 | 3.9454 |
Properties physicochemical experimental obtained by the mechanic study.
The second method for the measurement of the kinematic viscosity is obtained by measuring the time of flow of a given volume of liquid under the effect of gravity (the dynamic viscosity (η) in (g.cm−1.s−1 or mPa.s) of a fluid is obtained by multiplying its kinematic viscosity (γ) in (cm2.s−1 or stokes (cSt)) by its density (ρ)). Experimentally not having a viscometer the measurement of the time of flow of a volume V = 10 cm3 of liquid in a graduated burette of length 20 cm, the temperature of 20 °C the results are grouped in Table 7 gave: η = γ/ρ with ρ in g.cm−3 [26].
Samples | Time | Distance | Dyn Viscosity | Kin Viscosity | Volume |
---|---|---|---|---|---|
t (s) | d (cm) | γ (mPa.s) | η (mm2 s−1) | V (cm3) | |
Bio-oil (Seeds) | 0.116 | 20 | 3.869 | 4.310 | 10 |
Bio-oil (Shells) | 0.118 | 20 | 3.734 | 4.237 | 10 |
Commercial Diesel 1 | 0.126 | 20 | 3.293 | 3.968 | 10 |
Commercial Diesel 2 | 0.125 | 20 | 3.318 | 4000 | 10 |
Commercial Diesel 3 | 0.128 | 20 | 3.243 | 3.906 | 10 |
Properties physicochemical experimental obtained by the volume study.
We can deduce from the unit of kinematic viscosity the relationship that links the volume of liquid, the time of decantation and the length of the burette γ = V/L.t These results allow to highlight the small difference in viscosity between the bio-oil of seeds and shells of cistus and biodiesel. So we can improve the density of our bio-oil by adding a percentage of ethanol to increase the calorific value and thus bringing its density closer to the density of commercial fuels. To improve the bio-oil we can refine it by the reactions of trans-esterification to mimic the acids and the methyl esters of the vegetable oils as well as the ethyl ethers.
To confirm the experimental results found in this study concerning viscosity and density, measurements results are obtained at 20°C, were made using an apparatus (Anton paar DMATM4500M) with a (Software Version 2.93.9364.129) (Table 8).
Physical properties | Cistus | Commercial | |||
---|---|---|---|---|---|
Seeds | Shells | Diesel 1 | Diesel 2 | Diesel 3 | |
Appearance | Typically a dark brown free flowing liquid | Yellowish | |||
Odor | A distinctive smoky smell | Aromatic | |||
Calorific value (MJ Kg−1) | 37.93 | 37.05 | 41.50 | 43.20 | 42.35 |
Density (mg cm−3) | 897.6 | 881.3 | 829.9 | 829.4 | 830.3 |
Dyn Viscosity (mPa.s) | 3.768 | 3.716 | 3.306 | 3.255 | 3.254 |
Kin Viscosity (mm2 s−1) | 4.198 | 4.217 | 3.986 | 3.922 | 3.919 |
pH | 3.8 | 4.02 | |||
Miscibility | Methanol, Ethanol, Toluene, diesel, and Petrol |
Fuel properties of cistus seeds and shells pyrolysis oil.
A parametric study focused mainly on the impact of temperature, size and heating rate on the yield of pyrolysates. The ex-beech liquids show high solid residue and gas contents, good homogeneity and yields up to 52.24% for seeds and 53.34% for shells at 450°C. Chemical analyses were also carried out to characterize the pyrolysis products obtained in order to determine the oxygen, carbon and hydrogen contents in the solid residues and in the liquids.
So far, the percentage of C, O, N and H of the pyrolysis oils as a whole is high compared to other biomasses located in the literature and also present important and very high calorific powers in comparison with wood and with other biomass as castor, black cumin, karanja, apricol, walnut and hornbeam The main innovative character of this study lies in the adopted approach which consists in valorizing the bio-oils of pyrolysis, in particular in the production of biofuels in a first time and in a second time the synthesis of chemical products with the aim of use in cosmetic, pharmaceutical and food. The valorization of the solid (charcoal) as a bioadsorbent which will be detailed in another chapter.
This work is the result of research on the valorization of bioresources, it is a chapter of my doctoral thesis.
The author declares no conflict of interest.
Not applicable.
Not applicable.
Not applicable.
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\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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Transcriptome sequencing or RNA-seq using next-generation sequencing (short and long reads) is the most widely deployed technology for accurate quantification of gene expression. According to the biological aim of the experiment, replications, platform, and chemistries, propelling improvement has been demonstrated and documented using RNA-seq in plants, humans, animals, and clinical sciences with respect to gene expression of mRNA, small non-coding, long non-coding RNAs, alternative splice variations, isoform variations, gene fusions, single-nucleotide variants. Integrating transcriptome sequencing with other techniques such as chromatin immunoprecipitation, methylation, genome-wide association studies, manifests insights into genetic and epigenetic regulation. Epi-transcriptome including RNA methylation, modification, and alternative polyadenylation events can also be explored through long-read sequencing. 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The enzymes of the glycolytic pathway presenting the greatest multiplicity were phosphofructokinase, fructose 1,6-bisphosphate aldolase, glyceraldehyde-3-phosphate dehydrogenase, and pyruvate kinase. The genes that encode citrate synthase and subunits of the succinate dehydrogenase complex are the ones that show the greatest multiplicity, while in the phosphoenolpyruvate-pyruvate-oxaloacetate node, only malic enzymes and pyruvate phosphate dikinase present two copies in some Streptomyces. The extra DNA from these multiple gene copies can be more than 50 kb, and the question arises whether all of these genes are transcribed and translated. As far as we know, there is few information about the transcription of these genes in any of this Streptomyces, nor if any of the activities that are encoded by a single gene could be limiting both for growth and for the formation of precursors of the antibiotics produced by these microorganisms. Therefore, it is important to study the transcription and translation of genes involved in carbon metabolism in antibiotic-producing Streptomyces growing on various sugars.",book:{id:"10893",title:"Actinobacteria",coverURL:"https://cdn.intechopen.com/books/images_new/10893.jpg"},signatures:"Toshiko Takahashi, Jonathan Alanís, Polonia Hernández and María Elena Flores"},{id:"82757",title:"Seed Dormancy: Induction, Maintenance and Seed Technology Approaches to Break Dormancy",slug:"seed-dormancy-induction-maintenance-and-seed-technology-approaches-to-break-dormancy",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.106153",abstract:"Dormancy is the major cause of erratic germination, patchy emergence and uneven seedling establishment in the field. These traits are exceedingly undesirable in crop production as future phases of growth and development are strongly linked to uniform seedling development at early growth phases. Variations in maturation time, and difficulty in managing abiotic and biotic stresses during pre- and postharvest are common consequences of uneven germination and seedling emergence. Minimizing this negative impact of dormancy in a seed lot is the major concern of all seed production companies. Generally, mature seeds show some considerable dormancy during which embryo growth is halted momentarily because one or more internal and external stimuli for growth resumption is/are absent. If the inhibition of seed germination is solely due to insufficient or complete absence of external signals, then the seed is in a state of quiescence. Otherwise, if linked to internal factors, then the seed is in a state of dormancy. Induction, maintenance, and release of dormancy are therefore related to Seed-dependent factors such as morphology, hormones, state of embryo maturity at seed dispersal and chemical inhibitors. This chapter focuses on species-dependent methods currently used to break dormancy, reduce germination time and improve emergence and seedling establishment.",book:{id:"11322",title:"Seed Biology Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11322.jpg"},signatures:"Tabi Kingsley Mbi, Ntsomboh Godswill Ntsefong and Tatah Eugene Lenzemo"},{id:"79168",title:"Pulses: A Potential Source of Valuable Protein for Human Diet",slug:"pulses-a-potential-source-of-valuable-protein-for-human-diet",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.99980",abstract:"Nutritional profile of pulses has significant importance in human diet with respect to protein and mineral quality and bioavailability. Protein energy malnutrition is widespread throughout the world especially among the developing countries. Pulses being rich in macronutrients such as protein from 20 to 26% and low in calories are most suitable for product development for target-oriented population. During last decade, the demand for pulse-based products with high protein and fiber, low glycemic index, and gluten free with more antioxidant showed increasing trend by the consumers. Drift of end-use application of pulses generated interest for research in all disciplines such as breeding, agronomy, food, and nutrition, etc. A great share of plant protein in human diet may be a critical step for reducing dependence on animal origin protein source. This chapter will review contribution or choice of plant-based protein from legumes or pulses with good-quality protein based on amino acid composition. Additionally, this overview can give insight into the development of new product with balanced nutritional quality and high protein contents as a potential protein supply for malnourished population.",book:{id:"12236",title:"Legumes Research- Volume 2",coverURL:"https://cdn.intechopen.com/books/images_new/12236.jpg"},signatures:"Saima Parveen, Amina Jamil, Imran Pasha and Farah Ahmad"},{id:"83043",title:"Applications of CRISPR/Cas9 for Selective Sequencing and Clinical Diagnostics",slug:"applications-of-crispr-cas9-for-selective-sequencing-and-clinical-diagnostics",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.106548",abstract:"In this chapter, we will discuss the applications of CRISPR/Cas9 in the context of clinical diagnostics. We will provide an overview of existing methods and their use cases in the diagnostic field. Special attention will be given to selective sequencing approaches using third-generation sequencing and PAM-site requirements. As target sequences in an AT-rich environment cannot easily be accessed by the commercially available SpCas9 due to rarity of NGG PAM-sites, new enzymes such as ScCas9 with PAM-site requirements of NNG will be highlighted. Original research on CRISPR/Cas9 systems to determine molecular glioma markers by enriching regions of interest will be discussed in the context of potential future applications in clinical diagnostics.",book:{id:"11804",title:"CRISPR Technology",coverURL:"https://cdn.intechopen.com/books/images_new/11804.jpg"},signatures:"Maximilian Evers, Björn Brändl, Franz-Josef Müller, Sönke Friedrichsen and Stephan Kolkenbrock"},{id:"83012",title:"Cotton Based Cellulose Nanocomposites: Synthesis and Application",slug:"cotton-based-cellulose-nanocomposites-synthesis-and-application",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.106473",abstract:"Nanocellulose is a renewable natural biomaterial which has risen to prominence due to its biodegradability and physiochemical properties making it a promising candidate to replace non-biodegradable synthetic fibers. Due to its profound qualities, nanocellulose extracted from cotton fibers have tremendous application potential and have been intensively studied particularly in the generation of nanofillers and as reinforcement components in polymer matrixes. Deposition of inorganic nanoparticles on cotton fabric result in antimicrobial textiles with multifunctional use particularly in manufacture of PPE and as filtration devices against environmental pollutants and pathogens. This chapter compiles three main sections. The first section gives an overview of the extent of work done in the creation and application potential of cotton-based nanocomposites. The second section describes the in situ and ex situ methods of nanoparticle deposition and self assembly on cotton fabrics to generate multifunctional cotton-based nanocomposites with antimicrobial potential while the final section describes the incorporation of cotton nanofibers in polymer matrices, their reinforcing properties, as well as surface modification to assist their incorporation. Finally in the conclusion, a summary of the up-to-date challenges and progresses is presented postulating the undiscovered arenas and future undertakings of this venture.",book:{id:"11362",title:"Cotton",coverURL:"https://cdn.intechopen.com/books/images_new/11362.jpg"},signatures:"Patricia Jayshree Samuel Jacob"}],onlineFirstChaptersTotal:606},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",isOpenForSubmission:!0,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. 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For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}]},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",biography:"Michele Lanza is Associate Professor of Ophthalmology at Università della Campania, Luigi Vanvitelli, Napoli, Italy. His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. He has also edited two international books and authored more than 150 communications or posters for the most important international and Italian ophthalmology conferences.",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}]},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. 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