\r\n\t
",isbn:"978-1-80356-363-3",printIsbn:"978-1-80356-362-6",pdfIsbn:"978-1-80356-364-0",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"969d1c6315b04584c2f011e03dad69c2",bookSignature:"Dr. Mansoor Zoveidavianpoor",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11929.jpg",keywords:"Drilling Performance, Drilling Tools, Well Design, Drilling Procedure, Rotary Drilling, Directional Drilling, Measuring-While-Drilling, Smart Well Technology, Environment Protection, Geothermal Drilling, Sustainable Drilling Fluids, Carbon Sequestration",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 18th 2022",dateEndSecondStepPublish:"March 18th 2022",dateEndThirdStepPublish:"May 17th 2022",dateEndFourthStepPublish:"August 5th 2022",dateEndFifthStepPublish:"October 4th 2022",remainingDaysToSecondStep:"2 months",secondStepPassed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Zoveidavianpoor has over 18 years of multidisciplinary oil and gas experience, built upon his technical, operational, and management roles in the industry and academia. He is a member of the Society of Petroleum Engineers (SPE), the Energy Institute, UK and is registered as a chartered petroleum engineer. He has published more than 50 publications on International peer-reviewed Journals and conferences, has contributed to 5 textbooks, and served in many scientific committees.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"92105",title:"Dr.",name:"Mansoor",middleName:null,surname:"Zoveidavianpoor",slug:"mansoor-zoveidavianpoor",fullName:"Mansoor Zoveidavianpoor",profilePictureURL:"https://mts.intechopen.com/storage/users/92105/images/system/92105.jpg",biography:"Dr. Mansoor Zoveidavianpoor has over 24 years of experience, built upon his technical, operational, and management roles in the industry and academia. Mansoor holds a BSc degree in Geology, MSc, and Ph.D. degrees both in Petroleum Engineering. He was involved in different disciplines such as project management, geology, flow assurance, piping construction, artificial intelligence, environmental engineering, drilling and production engineering, He has lectured several courses at the University Technology Malaysia (UTM), Petroleum University of Technology (PUT), and Islamic Azad University (IAU). He is a member of the Society of Petroleum Engineers (SPE) and registered as a Chartered Petroleum Engineer at Energy Institute, and EIA subject specialist at DOE Malaysia. He has published more than 50 publications on International peer-reviewed Journals and conferences, has contributed to 5 textbooks, and served in many scientific committees. Currently, he is working as an Associate Professor at UTM and involved in several consultancies in petroleum engineering and energy transition. Mansoor is actively involved in multidisciplinary studies and currently, his main focus is on Energy Transition.",institutionString:"PETRONAS",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"3",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"440212",firstName:"Elena",lastName:"Vracaric",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/440212/images/20007_n.jpg",email:"elena@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6561",title:"Current Topics in the Utilization of Clay in Industrial and Medical Applications",subtitle:null,isOpenForSubmission:!1,hash:"e80257a8be3236c4d1ae37c21b7d2671",slug:"current-topics-in-the-utilization-of-clay-in-industrial-and-medical-applications",bookSignature:"Mansoor Zoveidavianpoor",coverURL:"https://cdn.intechopen.com/books/images_new/6561.jpg",editedByType:"Edited by",editors:[{id:"92105",title:"Dr.",name:"Mansoor",surname:"Zoveidavianpoor",slug:"mansoor-zoveidavianpoor",fullName:"Mansoor Zoveidavianpoor"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5811",title:"Recent Insights in Petroleum Science and Engineering",subtitle:null,isOpenForSubmission:!1,hash:"33b7777178f4a179ba475e3e15405427",slug:"recent-insights-in-petroleum-science-and-engineering",bookSignature:"Mansoor Zoveidavianpoor",coverURL:"https://cdn.intechopen.com/books/images_new/5811.jpg",editedByType:"Edited by",editors:[{id:"92105",title:"Dr.",name:"Mansoor",surname:"Zoveidavianpoor",slug:"mansoor-zoveidavianpoor",fullName:"Mansoor Zoveidavianpoor"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6829",title:"Petroleum Chemicals",subtitle:"Recent Insight",isOpenForSubmission:!1,hash:"058919afbb548d3448e70238b4637e84",slug:"petroleum-chemicals-recent-insight",bookSignature:"Mansoor Zoveidavianpoor",coverURL:"https://cdn.intechopen.com/books/images_new/6829.jpg",editedByType:"Edited by",editors:[{id:"92105",title:"Dr.",name:"Mansoor",surname:"Zoveidavianpoor",slug:"mansoor-zoveidavianpoor",fullName:"Mansoor Zoveidavianpoor"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"13797",title:"Optical Techniques for Future Pacemaker Technology",doi:"10.5772/13748",slug:"optical-techniques-for-future-pacemaker-technology",body:null,keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/13797.pdf",chapterXML:null,downloadPdfUrl:"/chapter/pdf-download/13797",previewPdfUrl:"/chapter/pdf-preview/13797",totalDownloads:3401,totalViews:117,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:18,impactScoreQuartile:1,hasAltmetrics:0,dateSubmitted:"May 10th 2010",dateReviewed:null,datePrePublished:null,datePublished:"February 14th 2011",dateFinished:null,readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/13797",risUrl:"/chapter/ris/13797",book:{id:"23",slug:"modern-pacemakers-present-and-future"},signatures:"Yasuaki Kumamoto, Nicholas Isaac Smith, Katsumasa Fujita, Jun Ando and Satoshi Kawata",authors:[{id:"15778",title:"Dr.",name:"Nicholas Isaac",middleName:null,surname:"Smith",fullName:"Nicholas Isaac Smith",slug:"nicholas-isaac-smith",email:"nsmith@ap.eng.osaka-u.ac.jp",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:null,chapterReferences:null,footnotes:null,contributors:null,corrections:null},book:{id:"23",type:"book",title:"Modern Pacemakers",subtitle:"Present and Future",fullTitle:"Modern Pacemakers - Present and Future",slug:"modern-pacemakers-present-and-future",publishedDate:"February 14th 2011",bookSignature:"Mithilesh Kumar Das",coverURL:"https://cdn.intechopen.com/books/images_new/23.jpg",licenceType:"CC BY-NC-SA 3.0",editedByType:"Edited by",isbn:null,printIsbn:"978-953-307-214-2",pdfIsbn:"978-953-51-6423-4",reviewType:"peer-reviewed",numberOfWosCitations:60,isAvailableForWebshopOrdering:!0,editors:[{id:"61931",title:"Prof.",name:"Mithilesh",middleName:"Kuma",surname:"M Das",slug:"mithilesh-m-das",fullName:"Mithilesh M Das"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"983"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"13771",type:"chapter",title:"Information Technology Aspects of Integrated Cardiac Rhythm Disease Management",slug:"information-technology-aspects-of-integrated-cardiac-rhythm-disease-management",totalDownloads:3444,totalCrossrefCites:1,signatures:"Dieter Hayn, Hannes Kumpusch, Rene Labenbacher, Robert Modre-Osprian and Günter Schreier",reviewType:"peer-reviewed",authors:[{id:"13673",title:"Dr.",name:"Gunter",middleName:null,surname:"Schreier",fullName:"Gunter Schreier",slug:"gunter-schreier"},{id:"15827",title:"Dr.",name:"Dieter",middleName:null,surname:"Hayn",fullName:"Dieter Hayn",slug:"dieter-hayn"},{id:"15828",title:"Dr.",name:"Hannes",middleName:null,surname:"Kumpusch",fullName:"Hannes Kumpusch",slug:"hannes-kumpusch"},{id:"15829",title:"Dr.",name:"Robert",middleName:null,surname:"Modre-Osprian",fullName:"Robert Modre-Osprian",slug:"robert-modre-osprian"},{id:"15830",title:"Dr.",name:"Rene",middleName:null,surname:"Labenbacher",fullName:"Rene Labenbacher",slug:"rene-labenbacher"}]},{id:"13772",type:"chapter",title:"Different Automatic Mode Switching in DDDR Pacemakers",slug:"different-automatic-mode-switching-in-dddr-pacemakers",totalDownloads:15474,totalCrossrefCites:1,signatures:"Maurizio Santomauro, Carlo Duilio, Carla Riganti, Paolo Di Mauro, Gennaro Iapicca, Luca Auricchio, Alessio Borrelli and Pasquale Perrone Filardi",reviewType:"peer-reviewed",authors:[{id:"15782",title:"Prof.",name:"Maurizio",middleName:null,surname:"Santomauro",fullName:"Maurizio Santomauro",slug:"maurizio-santomauro"}]},{id:"13773",type:"chapter",title:"Advanced Techniques for CRT Implantation",slug:"advanced-techniques-for-crt-implantation",totalDownloads:6120,totalCrossrefCites:0,signatures:"Béla Merkely, Levente Molnár, Szabolcs Szilágyi and László Gellér",reviewType:"peer-reviewed",authors:[{id:"19149",title:"Dr.",name:"Levente",middleName:null,surname:"Molnár",fullName:"Levente Molnár",slug:"levente-molnar"},{id:"19167",title:"Prof.",name:"Béla",middleName:null,surname:"Merkely",fullName:"Béla Merkely",slug:"bela-merkely"},{id:"19168",title:"Dr.",name:"László",middleName:null,surname:"Gellér",fullName:"László Gellér",slug:"laszlo-geller"},{id:"19169",title:"Dr.",name:"Szabolcs",middleName:null,surname:"Szilágyi",fullName:"Szabolcs Szilágyi",slug:"szabolcs-szilagyi"}]},{id:"13774",type:"chapter",title:"The Alternative Atrial Pacing Sites",slug:"the-alternative-atrial-pacing-sites",totalDownloads:2736,totalCrossrefCites:0,signatures:"Jacek Gajek, Przemysław Skoczyński and Agnieszka Sławuta",reviewType:"peer-reviewed",authors:[{id:"15677",title:"Dr.",name:"Jacek",middleName:null,surname:"Gajek",fullName:"Jacek Gajek",slug:"jacek-gajek"}]},{id:"13775",type:"chapter",title:"Left Ventricular Endocardial Pacing Techniques as an Alternative for Ineffective Cardiac Resynchronization Therapy and the Role of Acute Hemodynamic Evaluation",slug:"left-ventricular-endocardial-pacing-techniques-as-an-alternative-for-ineffective-cardiac-resynchroni",totalDownloads:4167,totalCrossrefCites:1,signatures:"Berry M. van Gelder, Patrick Houthuizen, Mike G. Scheffer, Lukas Dekker and Frank A. Bracke",reviewType:"peer-reviewed",authors:[{id:"13930",title:"Dr.",name:"Berry",middleName:null,surname:"van Gelder",fullName:"Berry van Gelder",slug:"berry-van-gelder"},{id:"15736",title:"Dr.",name:"Patrick",middleName:null,surname:"Houthuizen",fullName:"Patrick Houthuizen",slug:"patrick-houthuizen"},{id:"15738",title:"Dr.",name:"Frank A.",middleName:null,surname:"Bracke",fullName:"Frank A. Bracke",slug:"frank-a.-bracke"},{id:"15739",title:"Dr.",name:"Lukas",middleName:null,surname:"Dekker",fullName:"Lukas Dekker",slug:"lukas-dekker"},{id:"15740",title:"Dr.",name:"Mike",middleName:null,surname:"Scheffer",fullName:"Mike Scheffer",slug:"mike-scheffer"}]},{id:"13776",type:"chapter",title:"Pacing Therapy in Infants and Children with Congenital and Acquired Complete Atrioventricular Block: Optimal Pacing Strategies, Management, and Follow-up",slug:"pacing-therapy-in-infants-and-children-with-congenital-and-acquired-complete-atrioventricular-block-",totalDownloads:5418,totalCrossrefCites:2,signatures:"Floris E.A. Udink ten Cate and Narayanswami Sreeram",reviewType:"peer-reviewed",authors:[null]},{id:"13777",type:"chapter",title:"Advantages of Right-Sided Implantation of Permanent Cardiac Pacemakers Performed by a Surgeon",slug:"advantages-of-right-sided-implantation-of-permanent-cardiac-pacemakers-performed-by-a-surgeon",totalDownloads:10755,totalCrossrefCites:0,signatures:"Davor Horvat",reviewType:"peer-reviewed",authors:[{id:"15641",title:"Dr.",name:"Davor",middleName:null,surname:"Horvat",fullName:"Davor Horvat",slug:"davor-horvat"}]},{id:"13778",type:"chapter",title:"Telemonitoring of the Pacemakers",slug:"telemonitoring-of-the-pacemakers",totalDownloads:12023,totalCrossrefCites:2,signatures:"Umashankar Lakshmanadoss, Abrar Shah and James P Daubert",reviewType:"peer-reviewed",authors:[{id:"13913",title:"Dr.",name:"Umashankar",middleName:null,surname:"Lakshmanadoss",fullName:"Umashankar Lakshmanadoss",slug:"umashankar-lakshmanadoss"},{id:"14368",title:"Dr.",name:"James",middleName:null,surname:"Daubert",fullName:"James Daubert",slug:"james-daubert"},{id:"27779",title:"Dr.",name:"Abrar",middleName:null,surname:"Shah",fullName:"Abrar Shah",slug:"abrar-shah"}]},{id:"13779",type:"chapter",title:"Remote Monitoring in Patients with Pacemakers and Implantable Cardioverter-Defibrillators: New Perspectives for Complex Therapeutic Management",slug:"remote-monitoring-in-patients-with-pacemakers-and-implantable-cardioverter-defibrillators-new-perspe",totalDownloads:6549,totalCrossrefCites:5,signatures:"Axel Müller, Thomas M. Helms, Hans-Jürgen Wildau, Jörg Otto Schwab and Christian Zugck",reviewType:"peer-reviewed",authors:[{id:"14408",title:"Prof.",name:"Axel",middleName:null,surname:"Müller",fullName:"Axel Müller",slug:"axel-muller"},{id:"15385",title:"Prof.",name:"Thomas M.",middleName:null,surname:"Helms",fullName:"Thomas M. Helms",slug:"thomas-m.-helms"},{id:"15386",title:"Prof.",name:"Hans-Jürgen",middleName:null,surname:"Wildau",fullName:"Hans-Jürgen Wildau",slug:"hans-jurgen-wildau"},{id:"15387",title:"Prof.",name:"Jörg Otto",middleName:null,surname:"Schwab",fullName:"Jörg Otto Schwab",slug:"jorg-otto-schwab"},{id:"15388",title:"Prof.",name:"Christian",middleName:null,surname:"Zugck",fullName:"Christian Zugck",slug:"christian-zugck"}]},{id:"13780",type:"chapter",title:"Remote Monitoring of Implantable Pacemaker, Cardioverter Defibrillator, and Cardiac Resynchronizer",slug:"remote-monitoring-of-implantable-pacemaker-cardioverter-defibrillator-and-cardiac-resynchronizer",totalDownloads:6925,totalCrossrefCites:1,signatures:"Milton E. Guevara-Valdivia and Pedro Iturralde Torres",reviewType:"peer-reviewed",authors:[{id:"13655",title:"Prof.",name:"Milton E.",middleName:null,surname:"Guevara-Valdivia",fullName:"Milton E. Guevara-Valdivia",slug:"milton-e.-guevara-valdivia"},{id:"23795",title:"Dr.",name:"Pedro",middleName:null,surname:"Iturralde Torres",fullName:"Pedro Iturralde Torres",slug:"pedro-iturralde-torres"}]},{id:"13781",type:"chapter",title:"Interaction between the RF Field of MRI Apparatus and Pacemakers",slug:"interaction-between-the-rf-field-of-mri-apparatus-and-pacemakers",totalDownloads:3478,totalCrossrefCites:1,signatures:"Stefano Pisa, Paolo Bernardi and Emanuele Piuzzi",reviewType:"peer-reviewed",authors:[{id:"15728",title:"Dr.",name:"Stefano",middleName:null,surname:"Pisa",fullName:"Stefano Pisa",slug:"stefano-pisa"},{id:"16127",title:"Dr.",name:"Paolo",middleName:null,surname:"Bernardi",fullName:"Paolo Bernardi",slug:"paolo-bernardi"},{id:"16129",title:"Dr.",name:"Emanuele",middleName:null,surname:"Piuzzi",fullName:"Emanuele Piuzzi",slug:"emanuele-piuzzi"}]},{id:"13782",type:"chapter",title:"Adverse Interactions between ICD and Permanent Pacemaker Systems",slug:"adverse-interactions-between-icd-and-permanent-pacemaker-systems",totalDownloads:3449,totalCrossrefCites:0,signatures:"Dirk Bastian and Klaus Fessele",reviewType:"peer-reviewed",authors:[{id:"14302",title:"Dr.",name:"Dirk",middleName:null,surname:"Bastian",fullName:"Dirk Bastian",slug:"dirk-bastian"},{id:"14402",title:"Dr.",name:"Klaus",middleName:null,surname:"Fessele",fullName:"Klaus Fessele",slug:"klaus-fessele"},{id:"14403",title:"Dr.",name:"Konrad",middleName:null,surname:"Göhl",fullName:"Konrad Göhl",slug:"konrad-gohl"}]},{id:"13783",type:"chapter",title:"Electromagnetic Interference of the Pacemakers",slug:"electromagnetic-interference-of-the-pacemakers",totalDownloads:61066,totalCrossrefCites:4,signatures:"Umashankar Lakshmanadoss, Priya Chinnachamy and James P Daubert",reviewType:"peer-reviewed",authors:[{id:"13913",title:"Dr.",name:"Umashankar",middleName:null,surname:"Lakshmanadoss",fullName:"Umashankar Lakshmanadoss",slug:"umashankar-lakshmanadoss"},{id:"14368",title:"Dr.",name:"James",middleName:null,surname:"Daubert",fullName:"James Daubert",slug:"james-daubert"},{id:"27778",title:"Prof.",name:"saadia",middleName:null,surname:"Sherazi",fullName:"saadia Sherazi",slug:"saadia-sherazi"},{id:"59543",title:"Dr.",name:"Priya",middleName:null,surname:"Chinnachamy",fullName:"Priya Chinnachamy",slug:"priya-chinnachamy"}]},{id:"13784",type:"chapter",title:"Magnetic Resonance Imaging with MR Conditional Cardiac Pacemakers",slug:"magnetic-resonance-imaging-with-mr-conditional-cardiac-pacemakers",totalDownloads:7363,totalCrossrefCites:0,signatures:"Josef Vymazal, Aaron Rulseh, Miloš Táborský and Radovan Žáček",reviewType:"peer-reviewed",authors:[{id:"13768",title:"Dr.",name:"Josef",middleName:null,surname:"Vymazal",fullName:"Josef Vymazal",slug:"josef-vymazal"},{id:"15755",title:"Prof.",name:"Miloš",middleName:null,surname:"Táborský",fullName:"Miloš Táborský",slug:"milos-taborsky"},{id:"15756",title:"Dr.",name:"Radovan",middleName:null,surname:"Žáček",fullName:"Radovan Žáček",slug:"radovan-zacek"},{id:"23827",title:"Dr.",name:"Aaron",middleName:null,surname:"Rulseh",fullName:"Aaron Rulseh",slug:"aaron-rulseh"}]},{id:"13785",type:"chapter",title:"Complications of Pacemaker Implantation",slug:"complications-of-pacemaker-implantation",totalDownloads:18124,totalCrossrefCites:1,signatures:"Michele Schiariti, Mariateresa Cacciola and Paolo Emilio Puddu",reviewType:"peer-reviewed",authors:[{id:"14745",title:"Prof.",name:"Paolo Emilio",middleName:null,surname:"Puddu",fullName:"Paolo Emilio Puddu",slug:"paolo-emilio-puddu"},{id:"14746",title:"Prof.",name:"Michele",middleName:null,surname:"Schiariti",fullName:"Michele Schiariti",slug:"michele-schiariti"},{id:"14823",title:"Dr.",name:"Mariateresa",middleName:null,surname:"Cacciola",fullName:"Mariateresa Cacciola",slug:"mariateresa-cacciola"}]},{id:"13786",type:"chapter",title:"Common Pacemaker Problems: Lead and Pocket Complications",slug:"common-pacemaker-problems-lead-and-pocket-complications",totalDownloads:105895,totalCrossrefCites:1,signatures:"Enes Elvin Gul and Mehmet Kayrak",reviewType:"peer-reviewed",authors:[{id:"13568",title:"Dr.",name:"Enes Elvin",middleName:null,surname:"Gul",fullName:"Enes Elvin Gul",slug:"enes-elvin-gul"},{id:"15681",title:"Dr.",name:"Mehmet",middleName:null,surname:"Kayrak",fullName:"Mehmet Kayrak",slug:"mehmet-kayrak"}]},{id:"13787",type:"chapter",title:"Conduction Disturbances after the Superior Septal Approach for Mitral Valve Repair",slug:"conduction-disturbances-after-the-superior-septal-approach-for-mitral-valve-repair",totalDownloads:2658,totalCrossrefCites:0,signatures:"Yoshio Misawa, Shin-ichi Ohki, Yuichiro Kaminishi, Yasuhito Sakano, Kei Aizawa, Tsutomu Saito, Hiroaki Konishi and Arata Muraoka",reviewType:"peer-reviewed",authors:[{id:"15468",title:"Prof.",name:"Yoshio",middleName:null,surname:"Misawa",fullName:"Yoshio Misawa",slug:"yoshio-misawa"}]},{id:"13788",type:"chapter",title:"Complication of Pacemaker Implantation: An Atrial Lead Perforation",slug:"complication-of-pacemaker-implantation-an-atrial-lead-perforation",totalDownloads:7108,totalCrossrefCites:1,signatures:"Kenji Sadamatsu",reviewType:"peer-reviewed",authors:[{id:"16115",title:"Dr.",name:"Kenji",middleName:null,surname:"Sadamatsu",fullName:"Kenji Sadamatsu",slug:"kenji-sadamatsu"}]},{id:"13789",type:"chapter",title:"Cardiac Perforation Associated with a Pacemaker or ICD Lead",slug:"cardiac-perforation-associated-with-a-pacemaker-or-icd-lead",totalDownloads:13716,totalCrossrefCites:0,signatures:"Seil Oh",reviewType:"peer-reviewed",authors:[{id:"14690",title:"Dr.",name:"Seil",middleName:null,surname:"Oh",fullName:"Seil Oh",slug:"seil-oh"}]},{id:"13790",type:"chapter",title:"Long-Term Consequences of Endocardial Leads Present in Cardiovascular System",slug:"long-term-consequences-of-endocardial-leads-present-in-cardiovascular-system",totalDownloads:2981,totalCrossrefCites:1,signatures:"Barbara Małecka",reviewType:"peer-reviewed",authors:[{id:"15560",title:"Dr.",name:"Barbara",middleName:null,surname:"Małecka",fullName:"Barbara Małecka",slug:"barbara-malecka"}]},{id:"13791",type:"chapter",title:"Pacing System Malfunction: Evaluation and Troubleshooting",slug:"pacing-system-malfunction-evaluation-and-troubleshooting",totalDownloads:17274,totalCrossrefCites:3,signatures:"Majid Haghjoo",reviewType:"peer-reviewed",authors:[{id:"14665",title:"Dr.",name:"Majid",middleName:null,surname:"Haghjoo",fullName:"Majid Haghjoo",slug:"majid-haghjoo"}]},{id:"13792",type:"chapter",title:"Infections of Permanent Pacemakers and Implantable Cardioverter-Defibrillators",slug:"infections-of-permanent-pacemakers-and-implantable-cardioverter-defibrillators",totalDownloads:6712,totalCrossrefCites:0,signatures:"Metallidis Symeon and Pilalas Dimitris",reviewType:"peer-reviewed",authors:[{id:"13667",title:"Dr.",name:"Symeon",middleName:null,surname:"Metallidis",fullName:"Symeon Metallidis",slug:"symeon-metallidis"}]},{id:"13793",type:"chapter",title:"Pacemaker and Network Mechanisms of Neural Rhythm Generation",slug:"pacemaker-and-network-mechanisms-of-neural-rhythm-generation",totalDownloads:2691,totalCrossrefCites:1,signatures:"Thomas Nowotny and Mikhail I. Rabinovich",reviewType:"peer-reviewed",authors:[{id:"14209",title:"Dr.",name:"Mikhail I.",middleName:null,surname:"Rabinovich",fullName:"Mikhail I. Rabinovich",slug:"mikhail-i.-rabinovich"},{id:"14314",title:"Prof.",name:"Thomas",middleName:null,surname:"Nowotny",fullName:"Thomas Nowotny",slug:"thomas-nowotny"}]},{id:"13794",type:"chapter",title:"Network of Gut Pacemaker Cells: Spatio-Temporal Evaluation of Electrical Activity by Use of Microelectrode Array",slug:"network-of-gut-pacemaker-cells-spatio-temporal-evaluation-of-electrical-activity-by-use-of-microelec",totalDownloads:2749,totalCrossrefCites:0,signatures:"Shinsuke Nakayama, Mizuki Taniguchi and Hong-Nian Liu",reviewType:"peer-reviewed",authors:[{id:"16086",title:"Dr.",name:"Shinsuke",middleName:null,surname:"Nakayama",fullName:"Shinsuke Nakayama",slug:"shinsuke-nakayama"},{id:"16090",title:"Prof.",name:"Mizuki",middleName:null,surname:"Taniguchi",fullName:"Mizuki Taniguchi",slug:"mizuki-taniguchi"},{id:"16091",title:"Dr.",name:"Hong-Nian",middleName:null,surname:"Liu",fullName:"Hong-Nian Liu",slug:"hong-nian-liu"}]},{id:"13795",type:"chapter",title:"Possible Role or Respiratory Pacemaker Neurons in the Generation of Different Breathing Patterns",slug:"possible-role-or-respiratory-pacemaker-neurons-in-the-generation-of-different-breathing-patterns",totalDownloads:2859,totalCrossrefCites:0,signatures:"Peña-Ortega F",reviewType:"peer-reviewed",authors:[{id:"16094",title:"Dr.",name:"Fernando",middleName:null,surname:"Peña-Ortega",fullName:"Fernando Peña-Ortega",slug:"fernando-pena-ortega"}]},{id:"13796",type:"chapter",title:"Diaphragmatic Pacemaker",slug:"diaphragmatic-pacemaker",totalDownloads:7168,totalCrossrefCites:0,signatures:"Salim Surani",reviewType:"peer-reviewed",authors:[{id:"15654",title:"Dr.",name:"Salim",middleName:null,surname:"Surani",fullName:"Salim Surani",slug:"salim-surani"}]},{id:"13797",type:"chapter",title:"Optical Techniques for Future Pacemaker Technology",slug:"optical-techniques-for-future-pacemaker-technology",totalDownloads:3401,totalCrossrefCites:0,signatures:"Yasuaki Kumamoto, Nicholas Isaac Smith, Katsumasa Fujita, Jun Ando and Satoshi Kawata",reviewType:"peer-reviewed",authors:[{id:"15778",title:"Dr.",name:"Nicholas Isaac",middleName:null,surname:"Smith",fullName:"Nicholas Isaac Smith",slug:"nicholas-isaac-smith"}]},{id:"13798",type:"chapter",title:"Creation of a Biopacemaker: Lessons from the Sinoatrial Node",slug:"creation-of-a-biopacemaker-lessons-from-the-sinoatrial-node",totalDownloads:4324,totalCrossrefCites:0,signatures:"A. Dénise den Haan, Arie O. Verkerk and Hanno L. Tan",reviewType:"peer-reviewed",authors:[{id:"15634",title:"PhD.",name:"A. Dénise",middleName:null,surname:"Den Haan",fullName:"A. Dénise Den Haan",slug:"a.-denise-den-haan"},{id:"15637",title:"Dr.",name:"Arie O.",middleName:null,surname:"Verkerk",fullName:"Arie O. Verkerk",slug:"arie-o.-verkerk"}]},{id:"13799",type:"chapter",title:"Advances in Research on Pacemaking Function of Interstitial Cell of Cajal in Gastrointestinal Tract",slug:"advances-in-research-on-pacemaking-function-of-interstitial-cell-of-cajal-in-gastrointestinal-tract",totalDownloads:2412,totalCrossrefCites:0,signatures:"Wen-Xie Xu",reviewType:"peer-reviewed",authors:[{id:"14613",title:"Dr.",name:"Wen-Xie",middleName:null,surname:"Xu",fullName:"Wen-Xie Xu",slug:"wen-xie-xu"}]},{id:"13800",type:"chapter",title:"Biological Pacemaker – Main Ideas and Optimization",slug:"biological-pacemaker-main-ideas-and-optimization",totalDownloads:3325,totalCrossrefCites:0,signatures:"Han-Gang Yu and Yen-Chang Lin",reviewType:"peer-reviewed",authors:[{id:"14483",title:"Dr.",name:"Han-Gang",middleName:null,surname:"Yu",fullName:"Han-Gang Yu",slug:"han-gang-yu"}]},{id:"13801",type:"chapter",title:"The Functional Role of Chloride Channels in Cardiac Pacemaker Activity",slug:"the-functional-role-of-chloride-channels-in-cardiac-pacemaker-activity",totalDownloads:5100,totalCrossrefCites:0,signatures:"Zheng Maggie Huang and Dayue Darrel Duan",reviewType:"peer-reviewed",authors:[{id:"14222",title:"Dr.",name:"Dayue Darrel",middleName:null,surname:"Duan",fullName:"Dayue Darrel Duan",slug:"dayue-darrel-duan"},{id:"14223",title:"Dr.",name:"Zheng Maggie",middleName:null,surname:"Huang",fullName:"Zheng Maggie Huang",slug:"zheng-maggie-huang"}]},{id:"13802",type:"chapter",title:"The Funny Current in Cardiac Non-Pacemaker Cells: Functional Role and Pharmacological Modulation",slug:"the-funny-current-in-cardiac-non-pacemaker-cells-functional-role-and-pharmacological-modulation",totalDownloads:4835,totalCrossrefCites:2,signatures:"Laura Sartiani, Elisabetta Cerbai and Alessandro Mugelli",reviewType:"peer-reviewed",authors:[{id:"13800",title:"Dr.",name:"Laura",middleName:null,surname:"Sartiani",fullName:"Laura Sartiani",slug:"laura-sartiani"},{id:"13801",title:"Prof.",name:"Alessandro",middleName:null,surname:"Mugelli",fullName:"Alessandro Mugelli",slug:"alessandro-mugelli"},{id:"15772",title:"Prof.",name:"Elisabetta",middleName:null,surname:"Cerbai",fullName:"Elisabetta Cerbai",slug:"elisabetta-cerbai"}]}]},relatedBooks:[{type:"book",id:"358",title:"Advances in Electrocardiograms",subtitle:"Methods and Analysis",isOpenForSubmission:!1,hash:"a61fed85204779463e6e483483601fdf",slug:"advances-in-electrocardiograms-methods-and-analysis",bookSignature:"Richard M. Millis",coverURL:"https://cdn.intechopen.com/books/images_new/358.jpg",editedByType:"Edited by",editors:[{id:"45295",title:"PhD.",name:"Richard",surname:"Millis",slug:"richard-millis",fullName:"Richard Millis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"27004",title:"Cardiac Anatomy",slug:"cardiac-anatomy",signatures:"Augusta Pelosi and Jack Rubinstein",authors:[{id:"44548",title:"Prof.",name:"Augusta",middleName:null,surname:"Pelosi",fullName:"Augusta Pelosi",slug:"augusta-pelosi"},{id:"112904",title:"Dr.",name:"Jack",middleName:null,surname:"Rubinstein",fullName:"Jack Rubinstein",slug:"jack-rubinstein"}]},{id:"27005",title:"Low-Frequency Response and the Skin-Electrode Interface in Dry-Electrode Electrocardiography",slug:"low-frequency-response-and-the-skin-electrode-interface-in-dry-electrode-electrocardiography",signatures:"Cédric Assambo and Martin J. Burke",authors:[{id:"49158",title:"MSc",name:"Cedric",middleName:null,surname:"Assambo",fullName:"Cedric Assambo",slug:"cedric-assambo"},{id:"58541",title:"Dr.",name:"Martin J.",middleName:null,surname:"Burke",fullName:"Martin J. Burke",slug:"martin-j.-burke"}]},{id:"27006",title:"Implantation Techniques of Leads for Left Ventricular Pacing in Cardiac Resynchronization Therapy and Electrocardiographic Consequences of the Stimulation Site",slug:"implantation-techniques-of-leads-for-left-ventricular-pacing-in-cardiac-resynchronization-therapy-an",signatures:"Michael Scheffer and Berry M. van Gelder",authors:[{id:"59887",title:"Dr.",name:"Mike",middleName:null,surname:"Scheffer",fullName:"Mike Scheffer",slug:"mike-scheffer"},{id:"60075",title:"Dr.",name:"Berry M.",middleName:null,surname:"Van Gelder",fullName:"Berry M. Van Gelder",slug:"berry-m.-van-gelder"}]},{id:"27007",title:"Non Contact Heart Monitoring",slug:"non-contact-heart-monitoring",signatures:"Lorenzo Scalise",authors:[{id:"49866",title:"Ph.D.",name:"Lorenzo",middleName:null,surname:"Scalise",fullName:"Lorenzo Scalise",slug:"lorenzo-scalise"}]},{id:"27008",title:"Automated Selection of Optimal ECG Lead Using Heart Instantaneous Frequency During Sleep",slug:"automated-selection-of-optimal-ecg-lead-using-heart-instantaneous-frequency-during-sleep",signatures:"Yeon-Sik Noh, Ja-Woong Yoon and Hyung-Ro Yoon",authors:[{id:"54557",title:"Prof.",name:"Hyungro",middleName:null,surname:"Yoon",fullName:"Hyungro Yoon",slug:"hyungro-yoon"},{id:"59494",title:"Mr",name:"Yeonsik",middleName:null,surname:"Noh",fullName:"Yeonsik Noh",slug:"yeonsik-noh"},{id:"94938",title:"Mr.",name:"Jawoong",middleName:null,surname:"Yoon",fullName:"Jawoong Yoon",slug:"jawoong-yoon"}]},{id:"27009",title:"A Novel Technique for ECG Morphology Interpretation and Arrhythmia Detection Based on Time Series Signal Extracted from Scanned ECG Record",slug:"a-novel-technique-for-ecg-morphology-interpretation-and-arrhythmia-detection-based-on-time-series-si",signatures:"Srinivasan Jayaraman, Prashanth Swamy, Vani Damodaran and N. Venkatesh",authors:[{id:"44796",title:"Mr",name:"Prashanth",middleName:null,surname:"Swamy",fullName:"Prashanth Swamy",slug:"prashanth-swamy"},{id:"59563",title:"Dr.",name:"Srinivasan",middleName:null,surname:"Jayaraman",fullName:"Srinivasan Jayaraman",slug:"srinivasan-jayaraman"},{id:"102939",title:"Ms.",name:"Vani",middleName:null,surname:"Damodaran",fullName:"Vani Damodaran",slug:"vani-damodaran"},{id:"111095",title:"Mr.",name:"Venkatesh",middleName:null,surname:"N",fullName:"Venkatesh N",slug:"venkatesh-n"}]},{id:"27010",title:"QT Interval and QT Variability",slug:"qt-interval-and-qt-variability",signatures:"Bojan Vrtovec and Gregor Poglajen",authors:[{id:"45238",title:"Prof.",name:"Bojan",middleName:null,surname:"Vrtovec",fullName:"Bojan Vrtovec",slug:"bojan-vrtovec"},{id:"58265",title:"Dr.",name:"Gregor",middleName:null,surname:"Poglajen",fullName:"Gregor Poglajen",slug:"gregor-poglajen"}]},{id:"27011",title:"The Electrocardiogram – Waves and Intervals",slug:"the-electrocardiogram-waves-and-intervals",signatures:"James E. Skinner, Daniel N. Weiss and Edward F. Lundy",authors:[{id:"51614",title:"Dr.",name:"James E.",middleName:null,surname:"Skinner",fullName:"James E. Skinner",slug:"james-e.-skinner"}]},{id:"27012",title:"Quantification of Ventricular Repolarization Dispersion Using Digital Processing of the Surface ECG",slug:"quantification-of-cardiac-ventricular-repolarization-dispersion-using-computarized-ecg-",signatures:"Ana Cecilia Vinzio Maggio, María Paula Bonomini, Eric Laciar Leber and Pedro David Arini",authors:[{id:"35003",title:"Prof.",name:"Eric",middleName:null,surname:"Laciar",fullName:"Eric Laciar",slug:"eric-laciar"},{id:"52549",title:"Dr.",name:"Maria Paula",middleName:null,surname:"Bonomini",fullName:"Maria Paula Bonomini",slug:"maria-paula-bonomini"},{id:"54658",title:"Prof.",name:"Pedro David",middleName:null,surname:"Arini",fullName:"Pedro David Arini",slug:"pedro-david-arini"},{id:"54666",title:"Mrs",name:"Ana Cecilia",middleName:null,surname:"Vinzio Maggio",fullName:"Ana Cecilia Vinzio Maggio",slug:"ana-cecilia-vinzio-maggio"}]},{id:"27013",title:"Medicines and QT Prolongation",slug:"medicines-and-qt-prolongation",signatures:"Ryuji Kato, Yoshio Ijiri and Kazuhiko Tanaka",authors:[{id:"54691",title:"Prof.",name:"Kazuhiko",middleName:null,surname:"Tanaka",fullName:"Kazuhiko Tanaka",slug:"kazuhiko-tanaka"},{id:"62337",title:"Dr.",name:"Ryuji",middleName:null,surname:"Kato",fullName:"Ryuji Kato",slug:"ryuji-kato"},{id:"62548",title:"Dr.",name:"Yoshio",middleName:null,surname:"Ijiri",fullName:"Yoshio Ijiri",slug:"yoshio-ijiri"}]},{id:"27014",title:"Concealed Conduction",slug:"concealed-conduction",signatures:"Hasan Ari and Kübra Doğanay",authors:[{id:"53424",title:"Dr.",name:"Hasan",middleName:null,surname:"Arı",fullName:"Hasan Arı",slug:"hasan-ari"},{id:"59709",title:"Dr.",name:"Kübra",middleName:null,surname:"Doğanay",fullName:"Kübra Doğanay",slug:"kubra-doganay"}]},{id:"27015",title:"Recognition of Cardiac Arrhythmia by Means of Beat Clustering on ECG-Holter Recordings",slug:"recognition-of-cardiac-arrhythmia-by-means-of-beat-clustering-on-ecg-holter-recordings",signatures:"J.L. Rodríguez-Sotelo, G. Castellanos-Domínguez, and C.D. Acosta-Medina",authors:[{id:"57691",title:"Dr.",name:"Jose",middleName:"Luis",surname:"Rodriguez-Sotelo",fullName:"Jose Rodriguez-Sotelo",slug:"jose-rodriguez-sotelo"},{id:"59773",title:"Dr.",name:"German",middleName:null,surname:"Castellanos",fullName:"German Castellanos",slug:"german-castellanos"}]},{id:"27016",title:"Electrocardiographic Analysis of Heart Rate Variability in Aging Heart",slug:"electrocardiographic-analysis-of-heart-rate-variability-in-aging-heart",signatures:"Elpidio Santillo, Monica Migale, Luca Fallavollita, Luciano Marini and Fabrizio Balestrini",authors:[{id:"48091",title:"Dr.",name:"Elpidio",middleName:null,surname:"Santillo",fullName:"Elpidio Santillo",slug:"elpidio-santillo"},{id:"57553",title:"Dr.",name:"Monica",middleName:null,surname:"Migale",fullName:"Monica Migale",slug:"monica-migale"},{id:"95196",title:"Dr.",name:"Luca",middleName:null,surname:"Fallavollita",fullName:"Luca Fallavollita",slug:"luca-fallavollita"},{id:"95199",title:"Dr.",name:"Luciano",middleName:null,surname:"Marini",fullName:"Luciano Marini",slug:"luciano-marini"},{id:"95203",title:"Dr.",name:"Fabrizio",middleName:null,surname:"Balestrini",fullName:"Fabrizio Balestrini",slug:"fabrizio-balestrini"}]},{id:"27017",title:"Changes of Sympathovagal Balance Measured by Heart Rate Variability in Gastroparetic Patients Treated with Gastric Electrical Stimulation",slug:"changes-of-sympathovagal-balance-measured-by-heart-rate-variability-in-gastroparetic-patients-treate",signatures:"Zhiyue Lin and Richard W. McCallum",authors:[{id:"50367",title:"Dr.",name:"Richard",middleName:null,surname:"McCallum",fullName:"Richard McCallum",slug:"richard-mccallum"},{id:"59813",title:"Mr.",name:"Zhiyue",middleName:null,surname:"Lin",fullName:"Zhiyue Lin",slug:"zhiyue-lin"}]},{id:"27018",title:"Associations of Metabolic Variables with Electrocardiographic Measures of Sympathovagal Balance in Healthy Young Adults",slug:"associations-of-metabolic-variables-with-electrocardiographic-measures-of-sympatho-vagal-balance-in-",signatures:"Richard M. Millis, Mark D. Hatcher, Rachel E. Austin, Vernon Bond and Kim L. Goring",authors:[{id:"45295",title:"PhD.",name:"Richard",middleName:"M",surname:"Millis",fullName:"Richard Millis",slug:"richard-millis"},{id:"61415",title:"Dr.",name:"Vernon",middleName:null,surname:"Bond",fullName:"Vernon Bond",slug:"vernon-bond"},{id:"95252",title:"MSc.",name:"Mark",middleName:null,surname:"Hatcher",fullName:"Mark Hatcher",slug:"mark-hatcher"},{id:"95255",title:"Dr.",name:"Kim",middleName:null,surname:"Goring",fullName:"Kim Goring",slug:"kim-goring"},{id:"105497",title:"MSc.",name:"Rachel",middleName:null,surname:"Austin",fullName:"Rachel Austin",slug:"rachel-austin"}]},{id:"27019",title:"An Analogue Front-End System with a Low-Power On-Chip Filter and ADC for Portable ECG Detection Devices",slug:"an-analogue-front-end-system-with-a-low-power-on-chip-filter-and-adc-for-portable-ecg-detection-devi",signatures:"Shuenn-Yuh Lee, Jia-Hua Hong, Jin-Ching Lee and Qiang Fang",authors:[{id:"58865",title:"Prof.",name:"Shuenn-Yuh",middleName:null,surname:"Lee",fullName:"Shuenn-Yuh Lee",slug:"shuenn-yuh-lee"},{id:"58867",title:"Dr.",name:"Jin-Ching",middleName:null,surname:"Lee",fullName:"Jin-Ching Lee",slug:"jin-ching-lee"},{id:"58868",title:"Dr.",name:"Qiang",middleName:null,surname:"Fang",fullName:"Qiang Fang",slug:"qiang-fang"},{id:"89752",title:"Dr.",name:"Jia-Hua",middleName:null,surname:"Hong",fullName:"Jia-Hua Hong",slug:"jia-hua-hong"}]},{id:"27020",title:"Electrocardiogram in an MRI Environment: Clinical Needs, Practical Considerations, Safety Implications, Technical Solutions and Future Directions",slug:"electrocardiogram-in-an-mri-environment-clinical-needs-practical-considerations-safety-implications-",signatures:"Thoralf Niendorf, Lukas Winter and Tobias Frauenrath",authors:[{id:"56761",title:"Prof.",name:"Thoralf",middleName:null,surname:"Niendorf",fullName:"Thoralf Niendorf",slug:"thoralf-niendorf"},{id:"59717",title:"MSc",name:"Lukas",middleName:null,surname:"Winter",fullName:"Lukas Winter",slug:"lukas-winter"},{id:"59718",title:"Dr.",name:"Tobias",middleName:null,surname:"Frauenrath",fullName:"Tobias Frauenrath",slug:"tobias-frauenrath"}]},{id:"27021",title:"Customized Heart Check System by Using Integrated Information of Electrocardiogram and Plethysmogram Outside the Driver’s Awareness from an Automobile Steering Wheel",slug:"customized-heart-check-system-by-using-integrated-information-of-electrocardiogram-and-plethysmogram",signatures:"Motohisa Osaka",authors:[{id:"49555",title:"Prof.",name:"Motohisa",middleName:null,surname:"Osaka",fullName:"Motohisa Osaka",slug:"motohisa-osaka"}]},{id:"27022",title:"Independent Component Analysis in ECG Signal Processing",slug:"independent-component-analysis-in-ecg-signal-processing",signatures:"Jarno M.A. Tanskanen and Jari J. Viik",authors:[{id:"48917",title:"Dr.",name:"Jarno",middleName:"M. A.",surname:"Tanskanen",fullName:"Jarno Tanskanen",slug:"jarno-tanskanen"},{id:"48965",title:"Dr.",name:"Jari",middleName:null,surname:"Viik",fullName:"Jari Viik",slug:"jari-viik"}]},{id:"27023",title:"Broadening the Exchange of Electrocardiogram Data from Intra-Hospital to Inter-Hospital",slug:"broadening-the-exchange-of-electrocardiogram-data-from-intra-hospital-to-inter-hospital",signatures:"Shizhong Yuan, Daming Wei and Weimin Xu",authors:[{id:"42911",title:"Prof.",name:"Daming",middleName:null,surname:"Wei",fullName:"Daming Wei",slug:"daming-wei"},{id:"42922",title:"Prof.",name:"Weimin",middleName:null,surname:"Xu",fullName:"Weimin Xu",slug:"weimin-xu"},{id:"50931",title:"Prof.",name:"Shizhong",middleName:null,surname:"Yuan",fullName:"Shizhong Yuan",slug:"shizhong-yuan"}]}]}],publishedBooks:[{type:"book",id:"129",title:"Ventricular Assist Devices",subtitle:null,isOpenForSubmission:!1,hash:"2b6b9dbd504cdf6ed9c20a742e3f2a9d",slug:"ventricular-assist-devices",bookSignature:"Jeffrey Shuhaiber",coverURL:"https://cdn.intechopen.com/books/images_new/129.jpg",editedByType:"Edited by",editors:[{id:"22152",title:"Dr.",name:"Jeffrey",surname:"Shuhaiber",slug:"jeffrey-shuhaiber",fullName:"Jeffrey Shuhaiber"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"290",title:"Cardiac Pacemakers",subtitle:"Biological Aspects, Clinical Applications and Possible Complications",isOpenForSubmission:!1,hash:"d336ffc14d9ab1745072534d4448305f",slug:"cardiac-pacemakers-biological-aspects-clinical-applications-and-possible-complications",bookSignature:"Mart Min",coverURL:"https://cdn.intechopen.com/books/images_new/290.jpg",editedByType:"Edited by",editors:[{id:"62780",title:"Prof.",name:"Mart",surname:"Min",slug:"mart-min",fullName:"Mart Min"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"331",title:"Cardiac Defibrillation",subtitle:"Mechanisms, Challenges and Implications",isOpenForSubmission:!1,hash:"90fa2e9b5ad435b6518f47da7ade1efd",slug:"cardiac-defibrillation-mechanisms-challenges-and-implications",bookSignature:"Natalia Trayanova",coverURL:"https://cdn.intechopen.com/books/images_new/331.jpg",editedByType:"Edited by",editors:[{id:"38381",title:"Dr.",name:"Natalia",surname:"Trayanova",slug:"natalia-trayanova",fullName:"Natalia Trayanova"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"358",title:"Advances in Electrocardiograms",subtitle:"Methods and Analysis",isOpenForSubmission:!1,hash:"a61fed85204779463e6e483483601fdf",slug:"advances-in-electrocardiograms-methods-and-analysis",bookSignature:"Richard M. Millis",coverURL:"https://cdn.intechopen.com/books/images_new/358.jpg",editedByType:"Edited by",editors:[{id:"45295",title:"PhD.",name:"Richard",surname:"Millis",slug:"richard-millis",fullName:"Richard Millis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1291",title:"Advances in Electrocardiograms",subtitle:"Clinical Applications",isOpenForSubmission:!1,hash:"956bc1bdc0de1de4908abbee641a17aa",slug:"advances-in-electrocardiograms-clinical-applications",bookSignature:"Richard M. Millis",coverURL:"https://cdn.intechopen.com/books/images_new/1291.jpg",editedByType:"Edited by",editors:[{id:"45295",title:"PhD.",name:"Richard",surname:"Millis",slug:"richard-millis",fullName:"Richard Millis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[]},onlineFirst:{chapter:{type:"chapter",id:"69686",title:"Endothelial Dysfunction in Cardiovascular Diseases",doi:"10.5772/intechopen.89365",slug:"endothelial-dysfunction-in-cardiovascular-diseases",body:'Vascular endothelium is considered as a largest endocrinal organ in the body, which has been shown to have a role in homeostasis in the body by exerting various functions [1]. It is made up of simple squamous epithelial cells that line blood vessels, lymphatic vessels, and the heart. The vascular endothelium has a total weight of about 1.5 kg. The endothelium has been recognized as a smart barrier and a key regulator of blood flow in micro- and macro-vascular circulation [2]. Endothelial function is very important, as it interacts with nearly every system in the body and selectively supplies nutrients and growth factors to every organ. On the other hand, endothelium also receives active metabolites and delivers them back to the circulation. Previously, it was believed that, endothelium is an inactive barrier between blood and extravascular tissues. However, recent research has shown that the vascular endothelium is an active paracrine, endocrine, and autocrine organ that is indispensable for the regulation of vascular tone and the maintenance of vascular homeostasis.
When immediate surrounding tissues are at basal conditions, the endothelium functions to maintain the vessel homeostasis, which favors vessel dilatation over vasoconstriction [3]. The endothelium being a dynamic reactive tissue, responds to various intrinsic physical stimuli, that is, shear stress, temperature, and transmural pressure and external stimuli, that is, temperature, mental stress, neurohumoral responses, immune response, and medications [2, 4].
Under normal conditions, endothelial cell maintains basal perfusion, which is determined by cardiac output, systemic, and local vascular resistance. Endothelial metabolism, which is a key regulator of perfusion, is impaired during several disease states like infection, injury, aging, and inflammation [5]. Local blood flow is the result of vascular relaxation and contraction that is balanced by endothelium-derived vaso-dilatative and vaso-constrictive factors. Among these factors, one signal molecule stands out as hub and target of many pathways and mechanisms that is nitric oxide (NO) [6]. It is important to understand the biochemical foundations of NO for endothelial function. NO, a potent vasodilator, is released form the endothelium due to shear stress. This NO is released by endothelial nitric oxide synthase (eNOS) by utilizing L-arginine as a substrate, which leads to the production of intracellular cyclic GMP [7]. However, in an event when the NO-dependent vasodilator mechanism is compromised, then the cytochrome-derived factors, natriuretic peptide [8], and prostacyclin [9]-dependent vasodilator mechanism came in action.
During disease state, there is impaired endothelial function, and this results in the balance shift towards prevailing constrictive factors and/or down-regulation of vaso-dilatative factors. An important counterweight in the vascular balance is cyclooxygenase (COX). This mostly induces COX-1 which is endogenous and may involve COX-2 if it is induced. The COXs have a key role in generating vasoconstrictive factors.
The COX enzymes transform arachidonic acid into endoperoxides and further into thromboxane A2 (TXA2) [10], prostaglandins, and prostacyclin [11]. Local presence of thrombin evokes inducible NO release. Platelet release of serotonin and ADP in turn increases NO synthesis and release in healthy endothelium to induce dilatation [12]. When vasodilatory function of endothelium is impaired, then the thrombus formation is mechanically promoted by vasoconstriction via TXA2 and by the direct effect of serotonin on smooth muscle cells [13].
Traditionally, endothelial dysfunction has been associated to pathological conditions that have altered anticoagulant function, impaired anti-inflammatory properties of the endothelium, impaired modulation of vascular growth, and dysregulation of vascular remodeling. For instance, a plethora of studies have confirmed the impairment of endothelium-dependent vasorelaxation caused by a loss of NO bioactivity/availability in the vessel wall [4]. The loss of NO bioavailability is the salient feature of a dysfunctional endothelium, which in turn is the sentinel of systemic or focal vascular disease. A number of previous studies have showed that most of the cardiovascular diseases were initiated from endothelial dysfunction. The decline in NO bioavailability may be caused by decreased expression of the endothelial cell eNOS [14], a lack of substrate or cofactors for eNOS [15], the presence of inhibitor of NOS [16], and alterations of cellular signaling, and finally, accelerated NO degradation by ROS [17]. Another aspect of endothelial dysfunction is impaired endothelial barrier function. Depending on the mode of pathophysiological change, this loss in barrier function may be localized or systemic. Localized loss of the selective barrier function (manifested as edema), coupled with the emigration of leukocytes, has been recognized as cardinal signs of inflammation [18]. From an immunological context, the body’s primary reaction to tissue injury or infection is the leukocyte interacting with endothelium. However, from the perspective of hemostasis and thrombosis, endothelial dysfunction is characterized by activation of pro-inflammatory and pro-coagulant molecules, as well as the suppression of anti-inflammatory and anti-coagulant molecules. The intact and normal functioning endothelial lining provides a stable reservoir for blood as its luminal surface does not activate the coagulation cascade or promote leukocyte-platelet adhesion, and it also exhibits anticoagulant and fibrinolytic properties [19]. Systemic endothelial dysfunction may lead to widespread inflammation, vascular leakage, thrombocytopenia, and disseminated intravascular coagulation (DIC). On the other hand, localized endothelial dysfunction and leukocyte adhesion may lead to venous thrombosis. Other than altered endothelial barrier function, localized endothelial dysfunction also leads to tissue factor induction and increased von Willebrand factor (vWF) release that shifts the homeostatic balance towards the pro-coagulant-pro-inflammatory phenotype [20]. Intact endothelium release pro-fibrinolytic molecules like tissue plasminogen activator (TPA) [21]. Endothelial dysfunction suppressed TPA release, thereby impairing fibrinolytic function of endothelium [22]. In contrast to venous endothelial cells and microvascular endothelial cells, arterial endothelial cells are surrounded by a vascular smooth muscle layer and adventitial layer. Arterial endothelial cells physiologically experience high sheer stress and synthesize ample amount of NO that facilitate vascular relaxation. In the context of atherogenesis, endothelial cell dysfunction is mainly characterized by a loss of anatomical integrity of the intima, as described by the seminal
Endothelial dysfunction of lesion-prone areas of the arterial vasculature leads to atherosclerotic plaque formation [28]. Sequential deterioration of arterial vasculature along with increased sheer stress contributes to lesion formation. Endothelial dysfunction is one of the early events that are responsible for the deterioration of arterial vasculature [29]. Recent insight into the cellular mechanisms involved in atherogenesis shows that deleterious modifications of endothelial physiology or metabolism is the initial event of vascular remodeling that represents a crucial step in the development of atherosclerosis and are also involved in the development of plaque and the occurrence of atherosclerosis [2]. The sequential event including focal permeation, trapping, and physicochemical modification of circulating lipoprotein particles in the sub-endothelial space constructs an inflammatory lesion [30]. This initiates a coordinated cellular signaling, followed by complex pathogenic sequence and endothelial activation. Activated endothelial cells express several cell adhesion molecules, which facilitate selective recruitment of circulating monocytes from the blood, and invade the tunica intima, where they differentiate into macrophages. These macrophages also abnormally take up modified lipoproteins to become foam cells (the hallmark of early fatty streak lesions) [31, 32]. The activated endothelium and macrophages release multiple chemokine and growth factors which act on neighboring smooth muscle cells (or precursors cell) [33] to induce their proliferation and synthesis of extracellular matrix components within the intimal compartment, thus generating a fibromuscular plaque34. This progressive structural remodeling of developing lesions results in the formation of a fibrous cap, overlying a lipid-rich necrotic core that consists of oxidized lipoproteins, cholesterol crystals, and cellular debris. This is also accompanied by varying degrees of matrix remodeling and calcification [34, 35]. The lateral edges of these complicated plaques also contain a rich population of inflammatory cells, that is, activated macrophages, T-lymphocyte, and dendritic cells [36], which secrete several cytokines and chemokines that further activate endothelial pro-inflammatory phenotype and contribute to structural instability of the plaque through release of proteolytic enzymes (matrix metalloproteases) that lead to modification of sub-endothelial matrix components [37]. Another aspect of atherogenesis is governed by lipoproteins, mainly low-density lipoproteins (LDL). This initial arterial remodeling through accumulation of lipids is known as fatty streak formation. The first changes in the arterial wall occur at the branch points of arteries, where adaptive intimal thickening occurs in response to normal hemodynamic stresses [38]. During the early stage of atherogenesis, LDL particles leave the blood and enter the arterial intima, composed of endothelial cells. Fat droplets (LDL) may also accumulate in the cytoplasm of vascular smooth muscle cells (VSMCs) [35]. LDL particles are then modified by enzymes and are oxidized into a highly reactive pro-inflammatory molecule (oxidized LDL), that is recognized by pattern recognition receptors, that is, Toll-like receptors (TLRs) present in endothelial cells as well as pro-inflammatory macrophages [39]. Oxidized LDL incites the reaction of the innate inflammatory system within the intima and contributes to vascular remodeling. Inflammation begins when activated endothelial cells (through TLRs) express cell adhesion molecules and VSMCs secrete chemokines and chemoattractants, which together draw monocytes, lymphocytes, mast cells, and neutrophils into the arterial wall [40]. Once monocytes enter into the arterial wall through the intima, they become activated into macrophages. These macrophages take up lipids as multiple small inclusions and become transferred into foam cells [41]. The degree of lipid accumulation is critical for early stage diagnosis of atherosclerosis. Atherosclerosis is believed to start when the lipid accumulation appears as confluent extracellular lipid pools and extracellular lipid cores with and decreased cellularity [42]. Endothelial cell dysfunction is also responsible for VSMC proliferation and differentiation to myofibroblast. In an intact vessel, VSMCs never come into contact with plasma proteins and are therefore devoid of growth factor present in plasma. In physiological conditions, VSMCs are always maintained in quiescent states. During early inflammation and endothelial cell activation, VSMCs receive signal from dying cells or growth factors that modify VSMCs to myofibroblast (more proliferative counterpart). Altered VSMCs (myofibroblast) also secrete proteoglycans, collagen, and elastic fibers into the sub-endothelial matrix [43]. This transformation of VSMCs further worsens the histological structure and leads to formation of thin-cap fibroatheroma formation [44]. Fibroatheroma can be of two different types depending on the content and stability of the plaque. Stability of the plaque also determines the fate of the fibroatheroma. Unstable fibroatheroma leads to thrombotic plaque formation, whereas stable fibroatheroma accumulates calcium, becomes stiff, and eventually leads to occlusion [44, 45]. Unstable or vulnerable plaques may lead to a catastrophic transition into atherosclerotic lesion—frank plaque rupture, with luminal release of the highly thrombogenic contents [46, 47]. Else, some significant clinical sequelae can be seen from superficial intimal erosions, without any indication of plaque rupture [48]. Therefore, lately an acute transition appears leading to endothelial cell apoptosis, with localized endothelial denudation and thrombus formation leading to obstruction in regional blood flow [49, 50], whereas the stable lesions, having thick fibrous cap and less lipid as well as inflammatory cell content, can gradually invade on the lumen of the vessel causing ischemic symptoms without atherothrombotic events [51, 52]. Many ruptures of thin fibrous caps are clinically silent in that they heal by forming fibrous tissue matrices of cells, collagen fibers, and extracellular space but may rupture again with thrombus formation of the necrotic core, triggering an atherothrombotic occlusion. These cyclic changes of rupture, thrombosis, and healing may recur as many as four times at a single site in the arterial wall, resulting in multiple layers of healed tissue. In all these steps, calcium deposition in the wall of the vessels forms small aggregates initially, which turns into large nodules at later stage. In later stage, these plaques may rupture and expose the nodules, and it became sites for thrombus formation [47]. Therefore, the increasing number of plaques itself might become adequate to form significant stenosis, which may cause a shattering ischemic event due to flow restriction [53]. Based on its multiple regulatory roles throughout this complex series of events, it is evident that endothelial dysfunction constitutes a well-coordinated multicellular pathogenic sequence that leads to atherosclerosis.
Hypertension affects significantly to worldwide cardiovascular morbidity and mortality and is considered as a diagnostic factor for cardiovascular disease. Hypertension appears to have a complex association with endothelial dysfunction, a phenotypical alteration of the vascular endothelium that precedes the development of adverse cardiovascular events. Endothelial cells along with the vascular smooth muscle cells of resistance vessels (arteries and arterioles) regulate hypertension [54] as they continuously constrict and dilate according to the rhythm of cardiac cycle. In response to the blood flow (perfusion), the quiescent healthy endothelium continuously releases potent vasodilators, which have the potential to lower vascular resistance, thereby regulating the blood pressure [55]. In normal condition, basal perfusion is determined by cardiac output, systemic, and local resistance. In an intact healthy vessel, endothelial cell always maintains a vasodilatory rather than a vasoconstrictive phenotype. Endothelial dysfunction is a condition comprising not only attenuated endothelium-dependent vasodilatation but also an augmented inflammatory endothelial activation that leads to vasoconstriction. Endothelial dysfunction contributes to hypertension, whereas hypertension also leads to endothelial dysfunction. In healthy endothelial tissues, a balance between endothelium-derived relaxing factors (EDRFs) and endothelium-derived contracting factors (EDCFs) is maintained. Endothelial dysfunction disturbs this balance. Several vasodilatory and vasoconstrictive factors regulate this balance. The endothelium secretes a number of vasodilator factors including NO. Generation of NO can activate guanylate cyclase (cGMP), which causes vasodilation through relaxation of vascular smooth muscle cells [56]. Another vasodilatory factor PGI2 secreted by the endothelium inhibits platelet aggregation and vascular smooth muscle cell proliferation [57]. Endothelial cells also secrete several vascular contracting factors including angiotensin-II (Ang-II), endothelin-I (ET-I), dinucleotide uridine adenosine tetraphosphate (UP4A), and COX-derived TXA2 [58]. Endothelins (ETs) are potent vasoconstrictor molecules having a key role in vascular homeostasis. Although there are three types of ET, vascular ECs mainly produce only ET-1, which has prominent roles in vasoconstriction. Active ET molecule is generated by the actions of an ET converting enzyme (ECE) found on the endothelial cell membranes. There are two basic types of ET-1 receptors: ET-A and ET-B, G-protein coupled receptors. Under normal conditions, the ET-A receptor is dominant in blood vessels [59]. ET-1 exerts vasoconstriction through activation of dihydropyridine channel or DHP channel or long lasting Ca++ channels (L-type) by binding to ET-A receptors on vascular smooth muscle cells. Smooth muscle cells expressed both ET-A and ET-B receptors. However, endothelial cells express only ET-B receptors, which negatively regulate NO release. Another vasorelaxation factor adenosine released from endothelial cells acts through purinergic receptor and maintains vascular perfusion [60]. Other than these factors, several cytokines and chemokines also play an important role in hypertension. Inflammatory cytokine induces generation of reactive oxygen species (ROS), one of the critical factors that link endothelial dysfunction and hypertension [61]. It is well established that Ang-II induces NADPH oxidases (NOX). But recent finding indicates additional source of ROS generation. In small subcutaneous arteries, a significant portion of Ang-II induced ROS is produced by COX-2. In the mouse aorta, the mitochondrial monoamine oxidase is another mediator of ROS generation and Ang-II or inflammation-induced endothelial dysfunction [62]. Therefore, mitochondrial monoamine oxidase-A and monoamine oxidase-B are also induced due to endothelial dysfunction in the vessels and generate a significant amount of H2O2 sufficient to quench endothelial NO. In spite of that, other mitochondrial ROS generating systems, that is, p66Shc, also contribute to hypertension-induced ROS production. ROS production is also regulated by several intracellular signaling, which further attenuate endothelial dysfunction and hypertension.
Heart failure (HF) is the most common cause of hospitalization in cardiovascular disease with a high mortality rate. Despite novel treatment options for patients suffering from HF, morbidity and mortality rates are still high. The impact of the growing HF on global public health is a great concern in health care research. With the advancement of medical management, survival of acute coronary disease and cardiac ischemia has been improved. However, in myocardial infarction, prognosis is still poor, as HF with preserved ejection fraction (HFpEF) has a 65% mortality rate at 5 years. While the heart as the failing “pumping” organ was an initial focus in research and treatment, neurohumoral activation and subsequently the role of a failing endothelium were recognized and investigated in recent years. Traditionally, HF was recognized as impairment of cardiac muscle activity, known as cardiomyopathy. Later, it was found that altered perfusion in cardiac arteries due to atherogenesis also contributes to cardiac ischemia that leads to cardiomyopathy. Reduced myocardial perfusion due to impaired ventricular function is at least in part a consequence of reduced endothelium-dependent vasodilator capacity of coronary arteries. The prominent regulatory activity of the vascular endothelium in HF was discovered about two decades ago, and its assessment in different cardiovascular disorders, including HF, has been the focus of intense research [63]. On the other hand, declined peripheral vasodilation causes higher systemic and pulmonary vascular resistance and together with stiffness of conductance arteries leads to increased afterload. Elevated afterload further increases cardiac workload and therefore worsens myocardial function. The decreased exercise capability is aggravated by vasomotor dysfunction of the skeletal muscle vessel by increases vascular resistance. Altered endothelial metabolism further contributes to increasing cardiac afterload [13]. Indeed, various aspects of endothelial function are affected in heart failure, including vasomotor, hemostatic, antioxidant, and anti-inflammatory activities [63, 64]. Differences also exist in the pattern of endothelial dysfunction depending on etiology, severity, and stability of HF in individual patients. Endothelial dysfunction also plays a central role in HF. The failing heart is characterized by an altered redox state with overproduction of ROS. The increasing evidence suggests that the abnormal cardiac and vascular phenotypes characterizing the failing heart are caused in large part by imbalances between NO bioavailability and oxidative stress [65]. During initial stages of HF, inflammatory mediators from the myocardium and altered local shear forces modulate gene expression, leukocyte infiltration, increased cytokine production, increased ROS generation, and diminished NO bioavailability. Clinical studies showed significant up-regulation of plasma markers of endothelial activation (e.g. E-selectin) and endothelial damage (e.g. vWF) in HF [22, 63]. However, it is difficult to determine if endothelial dysfunction is the cause or effect of the HF. Therefore, HF is regarded as thrombotic complication. As mentioned earlier, during atherogenesis, decreased lumen of cardiac arteries leads to reduced perfusion to the heart muscle. This phenomenon is coupled with increased sheer stress and impaired blood flow. This reduced perfusion either led to ischemia–reperfusion injury or coronary artery thrombosis [63]. Studies showed that endothelial dysfunction is one of the principle mediators of ischemia–reperfusion injury and thrombosis. This explains the increased endothelial dysfunction markers in coronary artery disease, HF, and thrombosis.
The global burden of neurological diseases including cerebrovascular stroke has significantly increased, and development of new treatment modalities for cerebrovascular diseases is an urgent need. Cerebrovascular stroke can be broadly subdivided into acute ischemic stroke and hemorrhagic stroke [66]. Acute ischemic stroke is among the leading causes of death and long-term disability. Cerebrovascular stroke in small vessel has functional (lacunar stroke, cognitive impairment, gait, and movement disorders) and structural (small subcortical infarct, lacunar infarct, lacunes, white matter lesions, and micro bleeds) consequences. In the past few decades, the immense development of neuro-radiological methods enabled better imaging of cerebral blood vessels. From the clinical point of view, it is very important to identify the location of vascular lesion. However, the treatment strategies do not depend on the location of vascular impairment. It is now well recognized that endothelial dysfunction represents a systemic syndrome involving multiple vascular beds, including the cerebral vasculature [67]. Endothelial function is not uniform throughout the arterial system. It differs between organs and potentially also between different vascular beds within the same organ. Cerebral endothelium is probably one of the most specific types since it is the crucial element of the well-known blood-brain barrier (BBB). The BBB is a term used to describe the unique properties of the microvasculature of the central nervous system that protects the brain from harmful agents and pathogens [68]. CNS vessels are continuous non-fenestrated vessels, but also contain a series of additional properties that allow them to tightly regulate the movement of molecules, ions, and cells between the blood and the CNS. This heavily restricting barrier capacity allows BBB ECs to tightly regulate CNS homeostasis, which is critical to allow for proper neuronal function, as well as protect the CNS from toxins, pathogens, inflammation, injury, and disease. The cell-to-cell interaction with astrocytes, microglia, and neurons mainly played an important role for maintenance of BBB controlled by endothelial cells and pericytes [69].
However, the integrity of BBB is mainly disrupted due to decrease in endothelial cell-cell junction proteins and the detachment of pericytes from the endothelial membrane in homorganic condition [70]. Cerebral autoregulation maintains constant blood flow (CBF) through the brain in spite of changing mean arterial pressure. Autoregulation of cerebral blood flow consists of mechano- and chemo-regulation. The serum level of carbon dioxide (CO2) is directly controlled by the chemo-regulation independent of changes in mean arterial pressure [71]. However, mechano-regulation depends on transmural pressure gradient and endothelial vasodilatation.
From the above discussion, it is evident that CVDs and cardiovascular morbidity are associated with endothelial dysfunction, but the mechanistic links between inflammatory diseases, endothelial dysfunction, and CVDs have not been fully elucidated. The role of traditional cardiovascular risk factors in patients with inflammation, especially sterile inflammation, has received considerable attention, though traditional factors alone are insufficient to explain the excess burden of CVDs. It seems likely that sterile inflammation, a shared feature of CVDs, is involved in the pathogenesis of accelerated endothelial dysfunction.
Patients with chronic inflammatory/and or sterile inflammatory diseases are at high risk for cardiovascular morbidity and mortality. In many inflammatory diseases, this heightened risk of CVDs is reflected in early endothelial dysfunction, even in the absence of any other detectable diseases. Several others mechanisms, that is, auto-antibodies, oxidative stress, and interactions with traditional risk factors like dyslipidemia and insulin resistance might be involved. Therefore, further research in future is required to delineate the importance of these processes. So, the current approaches to diminish cardiovascular morbidity and mortality are focused on controlling traditional modifiable cardiovascular risk factors and reduction of disease risk. Therefore, the precise mechanisms leading to development of CVDs due to inflammation/or sterile inflammation need to explore. These studies might help to identify unique therapeutic targets to combat these diseases.
The endothelium therefore represents an integrator of vascular risk, and the study of its dysfunction may help elucidate mechanisms driving accelerated CVDs in future, which could help to develop therapeutic targets for control of CVDs.
This work was supported by grant Grant Challenges Canada (R-ST-POC-1807-13914) to GAK.
IntechOpen's Authorship Policy is based on ICMJE criteria for authorship. An Author, one must:
',metaTitle:"Authorship Policy",metaDescription:"IN TECH's Authorship Policy is based on ICMJE criteria for authorship. In order to be identified as an Author, one must:",metaKeywords:null,canonicalURL:"/page/authorship-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"All contributors who meet these criteria are listed as Authors. Their exact contributions should be described in the manuscript at the time of submission.
\\n\\nConversely, all contributors who do not meet these criteria should be listed in the Acknowledgments section of the manuscript, along with a short description of their specific contributions.
\\n\\nCHANGES IN AUTHORSHIP
\\n\\nIf it is felt necessary to make changes to the list of Authors after a manuscript has been submitted or published, it is the responsibility of the Author concerned to provide a valid reason to amend the published list. Additionally, all listed Authors must verify and approve the proposed changes in order for any amendments to be made.
\\n\\nAFFILIATION
\\n\\nAuthors are responsible for ensuring all addresses and emails provided are correct. Under affiliation(s) all Authors should indicate where the research was conducted. Please note that no changes to the affiliation(s) can be made after the chapter has been published.
\\n\\nPolicy last updated: 2017-05-29
\\n"}]'},components:[{type:"htmlEditorComponent",content:"All contributors who meet these criteria are listed as Authors. Their exact contributions should be described in the manuscript at the time of submission.
\n\nConversely, all contributors who do not meet these criteria should be listed in the Acknowledgments section of the manuscript, along with a short description of their specific contributions.
\n\nCHANGES IN AUTHORSHIP
\n\nIf it is felt necessary to make changes to the list of Authors after a manuscript has been submitted or published, it is the responsibility of the Author concerned to provide a valid reason to amend the published list. Additionally, all listed Authors must verify and approve the proposed changes in order for any amendments to be made.
\n\nAFFILIATION
\n\nAuthors are responsible for ensuring all addresses and emails provided are correct. Under affiliation(s) all Authors should indicate where the research was conducted. Please note that no changes to the affiliation(s) can be made after the chapter has been published.
\n\nPolicy last updated: 2017-05-29
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{"933869@":null},profiles:[],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6601},{group:"region",caption:"Middle and South America",value:2,count:5906},{group:"region",caption:"Africa",value:3,count:2400},{group:"region",caption:"Asia",value:4,count:12541},{group:"region",caption:"Australia and Oceania",value:5,count:1008},{group:"region",caption:"Europe",value:6,count:17561}],offset:0,limit:12,total:null},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish"},books:[{type:"book",id:"11551",title:"Blockchain",subtitle:null,isOpenForSubmission:!0,hash:"26f3d47bfbfd96e25e5b46001876cc48",slug:null,bookSignature:"Prof. Vardan Mkrttchian",coverURL:"https://cdn.intechopen.com/books/images_new/11551.jpg",editedByType:null,editors:[{id:"333134",title:"Prof.",name:"Vardan",surname:"Mkrttchian",slug:"vardan-mkrttchian",fullName:"Vardan Mkrttchian"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11555",title:"Ubiquitous and Pervasive Computing - New Trends and Opportunities",subtitle:null,isOpenForSubmission:!0,hash:"42b6f15e5d9044c3abd00c231efec806",slug:null,bookSignature:"Prof. Rodrigo da Rosa Righi",coverURL:"https://cdn.intechopen.com/books/images_new/11555.jpg",editedByType:null,editors:[{id:"69889",title:"Prof.",name:"Rodrigo",surname:"da Rosa Righi",slug:"rodrigo-da-rosa-righi",fullName:"Rodrigo da Rosa Righi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11609",title:"Fungicides - Application, Technologies, and Materials for the Future of Plant Disease Management",subtitle:null,isOpenForSubmission:!0,hash:"3a8c9d55c21ce8d69d2edc94f9e592f3",slug:null,bookSignature:"Dr. Mizuho Nita",coverURL:"https://cdn.intechopen.com/books/images_new/11609.jpg",editedByType:null,editors:[{id:"98153",title:"Dr.",name:"Mizuho",surname:"Nita",slug:"mizuho-nita",fullName:"Mizuho Nita"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11580",title:"Recent Advances in Canine Medicine",subtitle:null,isOpenForSubmission:!0,hash:"1806716f60b9be14fc05682c4a912b41",slug:null,bookSignature:"Dr. Carlos Eduardo Fonseca-Alves",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",editedByType:null,editors:[{id:"258334",title:"Dr.",name:"Carlos Eduardo",surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11506",title:"Antenna Arrays",subtitle:null,isOpenForSubmission:!0,hash:"1b378e33d6f6e73721ee0dacbbb89aa1",slug:null,bookSignature:"Prof. Hussain Al-Rizzo, Dr. Nijas Kunju and Dr. Aldebaro Klautau",coverURL:"https://cdn.intechopen.com/books/images_new/11506.jpg",editedByType:null,editors:[{id:"153384",title:"Prof.",name:"Hussain",surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11476",title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",subtitle:null,isOpenForSubmission:!0,hash:"8d41fa5f3a5da07469bbc121594bfd3e",slug:null,bookSignature:"Prof. Margherita Mori",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",editedByType:null,editors:[{id:"335401",title:"Prof.",name:"Margherita",surname:"Mori",slug:"margherita-mori",fullName:"Margherita Mori"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11873",title:"Arthroplasty - Advanced Techniques and Future Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"ced605018c59717c3e55f59474339ca9",slug:null,bookSignature:"M.D. Alessandro Rozim Zorzi",coverURL:"https://cdn.intechopen.com/books/images_new/11873.jpg",editedByType:null,editors:[{id:"80871",title:"M.D.",name:"Alessandro Rozim",surname:"Zorzi",slug:"alessandro-rozim-zorzi",fullName:"Alessandro Rozim Zorzi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11458",title:"Human-Robot Interaction - Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"2003e3388833e911f610e0cd9788a5e7",slug:null,bookSignature:"Dr. Ramana Vinjamuri",coverURL:"https://cdn.intechopen.com/books/images_new/11458.jpg",editedByType:null,editors:[{id:"196746",title:"Dr.",name:"Ramana",surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11648",title:"Current Status and Ecological Aspects of Seabirds",subtitle:null,isOpenForSubmission:!0,hash:"7754b354f7deebdb8576189aefbdbc5c",slug:null,bookSignature:"Dr. Muhammad Nawaz Rajpar",coverURL:"https://cdn.intechopen.com/books/images_new/11648.jpg",editedByType:null,editors:[{id:"183095",title:"Dr.",name:"Muhammad Nawaz",surname:"Rajpar",slug:"muhammad-nawaz-rajpar",fullName:"Muhammad Nawaz Rajpar"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11561",title:"Zeolite From Wastes - New Perspectives on Innovative Resources and Their Valorization Process",subtitle:null,isOpenForSubmission:!0,hash:"3ed0dfd842de9cd1143212415903e6ad",slug:null,bookSignature:"Dr. Claudia Belviso",coverURL:"https://cdn.intechopen.com/books/images_new/11561.jpg",editedByType:null,editors:[{id:"61457",title:"Dr.",name:"Claudia",surname:"Belviso",slug:"claudia-belviso",fullName:"Claudia Belviso"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11586",title:"Schizophrenia - Recent Advances and Patient-Centered Treatment Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"2ba14221aca01660b2547004d9b5c2d9",slug:null,bookSignature:"Dr. Jane Yip",coverURL:"https://cdn.intechopen.com/books/images_new/11586.jpg",editedByType:null,editors:[{id:"156214",title:"Dr.",name:"Jane",surname:"Yip",slug:"jane-yip",fullName:"Jane Yip"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11470",title:"Graphene - Recent Advances, Future Perspective and Applied Applications",subtitle:null,isOpenForSubmission:!0,hash:"409e022e3baf48795e816576a6ee66e3",slug:null,bookSignature:"Dr. Mujtaba Ikram, Dr. Asghari Maqsood and Dr. Aneeqa Bashir",coverURL:"https://cdn.intechopen.com/books/images_new/11470.jpg",editedByType:null,editors:[{id:"286820",title:"Dr.",name:"Mujtaba",surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba Ikram"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:43},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:11},{group:"topic",caption:"Business, Management and Economics",value:7,count:5},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:21},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:17},{group:"topic",caption:"Engineering",value:11,count:62},{group:"topic",caption:"Environmental Sciences",value:12,count:9},{group:"topic",caption:"Immunology and Microbiology",value:13,count:10},{group:"topic",caption:"Materials Science",value:14,count:29},{group:"topic",caption:"Mathematics",value:15,count:10},{group:"topic",caption:"Medicine",value:16,count:122},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:9},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:12},{group:"topic",caption:"Psychology",value:21,count:9},{group:"topic",caption:"Robotics",value:22,count:4},{group:"topic",caption:"Social Sciences",value:23,count:8},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:419},popularBooks:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4383},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",publishedDate:"May 18th 2022",numberOfDownloads:3340,editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1845,editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1096,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",publishedDate:"May 18th 2022",numberOfDownloads:995,editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3791,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",publishedDate:"May 11th 2022",numberOfDownloads:2982,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",publishedDate:"May 18th 2022",numberOfDownloads:559,editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",publishedDate:"May 18th 2022",numberOfDownloads:546,editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",publishedDate:"May 18th 2022",numberOfDownloads:539,editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",publishedDate:"May 18th 2022",numberOfDownloads:535,editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"1328",title:"Polyphonic Anthropology",slug:"polyphonic-anthropology",parent:{id:"273",title:"Social Anthropology",slug:"social-anthropology"},numberOfBooks:1,numberOfSeries:0,numberOfAuthorsAndEditors:18,numberOfWosCitations:7,numberOfCrossrefCitations:5,numberOfDimensionsCitations:14,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"1328",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"1627",title:"Polyphonic Anthropology",subtitle:"Theoretical and Empirical Cross-Cultural Fieldwork",isOpenForSubmission:!1,hash:"6afa49775807af8d361150283d2d5138",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",bookSignature:"Massimo Canevacci",coverURL:"https://cdn.intechopen.com/books/images_new/1627.jpg",editedByType:"Edited by",editors:[{id:"98092",title:"Prof.",name:"Massimo",middleName:null,surname:"Canevacci",slug:"massimo-canevacci",fullName:"Massimo Canevacci"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:1,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"33723",doi:"10.5772/37236",title:"Social Metabolism, Cultural Landscape, and Social Invisibility in the Forests of Rio de Janeiro",slug:"social-metabolism-cultural-landscape-and-social-invisibility-in-the-forests-of-rio-de-janeiro",totalDownloads:2648,totalCrossrefCites:0,totalDimensionsCites:6,abstract:null,book:{id:"1627",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",title:"Polyphonic Anthropology",fullTitle:"Polyphonic Anthropology - Theoretical and Empirical Cross-Cultural Fieldwork"},signatures:"Joana Stingel Fraga and Rogério Ribeiro de Oliveira",authors:[{id:"111899",title:"Dr.",name:"Joana",middleName:"Stingel",surname:"Fraga",slug:"joana-fraga",fullName:"Joana Fraga"},{id:"114649",title:"BSc.",name:"Joana",middleName:null,surname:"Stingel Fraga",slug:"joana-stingel-fraga",fullName:"Joana Stingel Fraga"}]},{id:"33727",doi:"10.5772/38061",title:"Why Are Latin Europeans Less Happy? The Impact of Hierarchy",slug:"why-are-latin-europeans-less-happy-the-impact-of-hierarchy",totalDownloads:2142,totalCrossrefCites:3,totalDimensionsCites:6,abstract:null,book:{id:"1627",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",title:"Polyphonic Anthropology",fullTitle:"Polyphonic Anthropology - Theoretical and Empirical Cross-Cultural Fieldwork"},signatures:"Gaël Brulé and Ruut Veenhoven",authors:[{id:"115405",title:"Prof.",name:"Ruut",middleName:null,surname:"Veenhoven",slug:"ruut-veenhoven",fullName:"Ruut Veenhoven"},{id:"138439",title:"MSc.",name:"Gaël",middleName:null,surname:"Brulé",slug:"gael-brule",fullName:"Gaël Brulé"}]},{id:"33725",doi:"10.5772/38358",title:"An Anthropological Approach to Understanding the Process of Legitimation: An Examination of Major League Baseball Emergence",slug:"an-anthropological-approach-to-understanding-the-process-of-legitimation-an-examination-of-major-lea",totalDownloads:2358,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"1627",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",title:"Polyphonic Anthropology",fullTitle:"Polyphonic Anthropology - Theoretical and Empirical Cross-Cultural Fieldwork"},signatures:"Aya Chacar and Sokol Celo",authors:[{id:"116832",title:"Dr.",name:"Sokol",middleName:null,surname:"Celo",slug:"sokol-celo",fullName:"Sokol Celo"},{id:"117288",title:"Dr.",name:"Aya",middleName:null,surname:"Chacar",slug:"aya-chacar",fullName:"Aya Chacar"}]},{id:"33717",doi:"10.5772/37976",title:"Frontier Effects and Tidemarks: A Commentary in the Anthropology of Borders",slug:"frontier-effects-and-tidemarks-a-commentary-in-the-anthropology-of-borders",totalDownloads:3191,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"1627",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",title:"Polyphonic Anthropology",fullTitle:"Polyphonic Anthropology - Theoretical and Empirical Cross-Cultural Fieldwork"},signatures:"Cosmin Radu",authors:[{id:"115035",title:"Mr.",name:"Cosmin",middleName:null,surname:"Radu",slug:"cosmin-radu",fullName:"Cosmin Radu"}]},{id:"33722",doi:"10.5772/38251",title:"Imprints of the Entrepreneurial State and Privatization on Worker Subjectivity - A Study of Iron Ore Mine Workers in Itabira - Minas Gerais, Brazil",slug:"imprints-of-the-entrepreneurial-state-and-privatization-on-worker-subjectivity-",totalDownloads:1796,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"1627",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",title:"Polyphonic Anthropology",fullTitle:"Polyphonic Anthropology - Theoretical and Empirical Cross-Cultural Fieldwork"},signatures:"Maria Cecilia Minayo",authors:[{id:"116236",title:"Dr.",name:"Maria",middleName:"Cecilia",surname:"De Souza Minayo",slug:"maria-de-souza-minayo",fullName:"Maria De Souza Minayo"}]}],mostDownloadedChaptersLast30Days:[{id:"33721",title:"Contributions of Anthropology to the Study of Organization: The Case of Funeral Home",slug:"contributions-of-anthropology-to-the-study-of-organization-the-case-of-funeral-homes",totalDownloads:3388,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"1627",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",title:"Polyphonic Anthropology",fullTitle:"Polyphonic Anthropology - Theoretical and Empirical Cross-Cultural Fieldwork"},signatures:"Claudia Patricia Vélez-Zapata",authors:[{id:"118177",title:"MSc.",name:"Claudia",middleName:null,surname:"Velez",slug:"claudia-velez",fullName:"Claudia Velez"}]},{id:"33727",title:"Why Are Latin Europeans Less Happy? The Impact of Hierarchy",slug:"why-are-latin-europeans-less-happy-the-impact-of-hierarchy",totalDownloads:2141,totalCrossrefCites:3,totalDimensionsCites:6,abstract:null,book:{id:"1627",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",title:"Polyphonic Anthropology",fullTitle:"Polyphonic Anthropology - Theoretical and Empirical Cross-Cultural Fieldwork"},signatures:"Gaël Brulé and Ruut Veenhoven",authors:[{id:"115405",title:"Prof.",name:"Ruut",middleName:null,surname:"Veenhoven",slug:"ruut-veenhoven",fullName:"Ruut Veenhoven"},{id:"138439",title:"MSc.",name:"Gaël",middleName:null,surname:"Brulé",slug:"gael-brule",fullName:"Gaël Brulé"}]},{id:"33718",title:"Culture, Language, and Knowledge About the Syncretism",slug:"culture-language-and-knowledge-about-the-syncretism",totalDownloads:3197,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"1627",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",title:"Polyphonic Anthropology",fullTitle:"Polyphonic Anthropology - Theoretical and Empirical Cross-Cultural Fieldwork"},signatures:"Cláudio Márcio do Carmo",authors:[{id:"117721",title:"Dr.",name:"Cláudio",middleName:"Márcio",surname:"Do Carmo",slug:"claudio-do-carmo",fullName:"Cláudio Do Carmo"}]},{id:"33722",title:"Imprints of the Entrepreneurial State and Privatization on Worker Subjectivity - A Study of Iron Ore Mine Workers in Itabira - Minas Gerais, Brazil",slug:"imprints-of-the-entrepreneurial-state-and-privatization-on-worker-subjectivity-",totalDownloads:1796,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"1627",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",title:"Polyphonic Anthropology",fullTitle:"Polyphonic Anthropology - Theoretical and Empirical Cross-Cultural Fieldwork"},signatures:"Maria Cecilia Minayo",authors:[{id:"116236",title:"Dr.",name:"Maria",middleName:"Cecilia",surname:"De Souza Minayo",slug:"maria-de-souza-minayo",fullName:"Maria De Souza Minayo"}]},{id:"33716",title:"The Matter of the Sovereignty of the Heathen Peoples",slug:"the-matter-of-the-sovereignty-of-the-heathen-peoples",totalDownloads:2277,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"1627",slug:"polyphonic-anthropology-theoretical-and-empirical-cross-cultural-fieldwork",title:"Polyphonic Anthropology",fullTitle:"Polyphonic Anthropology - Theoretical and Empirical Cross-Cultural Fieldwork"},signatures:"Maria Stella Ferreira Levy",authors:[{id:"116845",title:"Prof.",name:"Maria Stella",middleName:null,surname:"Ferreira Levy",slug:"maria-stella-ferreira-levy",fullName:"Maria Stella Ferreira Levy"}]}],onlineFirstChaptersFilter:{topicId:"1328",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"May 14th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:7,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"306970",title:"Mr.",name:"Amin",middleName:null,surname:"Tamadon",slug:"amin-tamadon",fullName:"Amin Tamadon",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002oHR5wQAG/Profile_Picture_1623910304139",institutionString:null,institution:{name:"Bushehr University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",institutionString:null,institution:{name:"Miguel Hernandez University",institutionURL:null,country:{name:"Spain"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",institutionString:null,institution:{name:"Alexandria University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. Neiva",profilePictureURL:"https://mts.intechopen.com/storage/users/213786/images/system/213786.png",institutionString:null,institution:{name:"University of Beira Interior",institutionURL:null,country:{name:"Portugal"}}},{id:"39275",title:"Prof.",name:"Herbert Ryan",middleName:null,surname:"Marini",slug:"herbert-ryan-marini",fullName:"Herbert Ryan Marini",profilePictureURL:"https://mts.intechopen.com/storage/users/39275/images/9459_n.jpg",institutionString:null,institution:{name:"University of Messina",institutionURL:null,country:{name:"Italy"}}},{id:"196218",title:"Dr.",name:"Pasquale",middleName:null,surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci",profilePictureURL:"https://mts.intechopen.com/storage/users/196218/images/system/196218.png",institutionString:null,institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}]},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano",profilePictureURL:"https://mts.intechopen.com/storage/users/313856/images/system/313856.png",institutionString:"University of Orléans",institution:{name:"University of Orléans",institutionURL:null,country:{name:"France"}}},{id:"33993",title:"Dr.",name:"Jose Carlos",middleName:null,surname:"Jimenez-Lopez",slug:"jose-carlos-jimenez-lopez",fullName:"Jose Carlos Jimenez-Lopez",profilePictureURL:"https://mts.intechopen.com/storage/users/33993/images/system/33993.jpg",institutionString:null,institution:{name:"Spanish National Research Council",institutionURL:null,country:{name:"Spain"}}},{id:"191770",title:"Dr.",name:"Mohamed A.",middleName:null,surname:"El-Esawi",slug:"mohamed-a.-el-esawi",fullName:"Mohamed A. El-Esawi",profilePictureURL:"https://mts.intechopen.com/storage/users/191770/images/system/191770.jpeg",institutionString:null,institution:{name:"Tanta University",institutionURL:null,country:{name:"Egypt"}}},{id:"247858",title:"Dr.",name:"Saddam",middleName:null,surname:"Hussain",slug:"saddam-hussain",fullName:"Saddam Hussain",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSF2aQAG/Profile_Picture_1625658281836",institutionString:null,institution:{name:"University of Agriculture Faisalabad",institutionURL:null,country:{name:"Pakistan"}}}]}]},overviewPageOFChapters:{paginationCount:0,paginationItems:[]},overviewPagePublishedBooks:{paginationCount:0,paginationItems:[]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11601",title:"Econometrics - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11601.jpg",hash:"bc8ab49e2cf436c217a49ca8c12a22eb",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 13th 2022",isOpenForSubmission:!0,editors:[{id:"452331",title:"Dr.",name:"Brian",surname:"Sloboda",slug:"brian-sloboda",fullName:"Brian Sloboda"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:19,paginationItems:[{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81271",title:"The Diversity of Parvovirus Telomeres",doi:"10.5772/intechopen.102684",signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"79909",title:"Cryopreservation Methods and Frontiers in the Art of Freezing Life in Animal Models",doi:"10.5772/intechopen.101750",signatures:"Feda S. Aljaser",slug:"cryopreservation-methods-and-frontiers-in-the-art-of-freezing-life-in-animal-models",totalDownloads:170,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"79782",title:"Avian Reproduction",doi:"10.5772/intechopen.101185",signatures:"Kingsley Omogiade Idahor",slug:"avian-reproduction",totalDownloads:151,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Kingsley O.",surname:"Idahor"}],book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"78802",title:"Intraovarian Gestation in Viviparous Teleosts: Unique Type of Gestation among Vertebrates",doi:"10.5772/intechopen.100267",signatures:"Mari-Carmen Uribe, Gabino De la Rosa-Cruz, Adriana García-Alarcón and Juan Carlos Campuzano-Caballero",slug:"intraovarian-gestation-in-viviparous-teleosts-unique-type-of-gestation-among-vertebrates",totalDownloads:184,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"79209",title:"Virtual Physiology: A Tool for the 21st Century",doi:"10.5772/intechopen.99671",signatures:"Carmen Nóbrega, Maria Aires Pereira, Catarina Coelho, Isabel Brás, Ana Cristina Mega, Carla Santos, Fernando Esteves, Rita Cruz, Ana I. Faustino-Rocha, Paula A. Oliveira, João Mesquita and Helena Vala",slug:"virtual-physiology-a-tool-for-the-21st-century",totalDownloads:137,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78849",title:"Application of Vermicompost Fertilizer in Aquaculture Nutrition: Review",doi:"10.5772/intechopen.100326",signatures:"Sonnia Nzilani Musyoka and Rita Nairuti",slug:"application-of-vermicompost-fertilizer-in-aquaculture-nutrition-review",totalDownloads:67,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Nutrition - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11416.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"78617",title:"Doppler Ultrasound in the Reproduction of Mares",doi:"10.5772/intechopen.98951",signatures:"Camila Silva Costa Ferreira and Rita de Cássia Lima Morais",slug:"doppler-ultrasound-in-the-reproduction-of-mares",totalDownloads:123,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"78543",title:"Pulmonary Vein: Embryology, Anatomy, Function and Disease",doi:"10.5772/intechopen.100051",signatures:"Chan I-Ping and Hsueh Tung",slug:"pulmonary-vein-embryology-anatomy-function-and-disease",totalDownloads:171,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78564",title:"Anatomy of the Rhesus Monkey (Macaca mulatta): The Essentials for the Biomedical Researcher",doi:"10.5772/intechopen.99067",signatures:"Christophe Casteleyn and Jaco Bakker",slug:"anatomy-of-the-rhesus-monkey-macaca-mulatta-the-essentials-for-the-biomedical-researcher",totalDownloads:308,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}}]},subseriesFiltersForOFChapters:[{caption:"Animal Nutrition",value:20,count:1,group:"subseries"},{caption:"Animal Reproductive Biology and Technology",value:28,count:7,group:"subseries"},{caption:"Animal Science",value:19,count:11,group:"subseries"}],publishedBooks:{paginationCount:10,paginationItems:[{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",slug:"animal-feed-science-and-nutrition-production-health-and-environment",publishedDate:"May 18th 2022",editedByType:"Edited by",bookSignature:"Amlan Kumar Patra",hash:"79944fc8fbbaa329aed6fde388154832",volumeInSeries:10,fullTitle:"Animal Feed Science and Nutrition - Production, Health and Environment",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",slug:"rabies-virus-at-the-beginning-of-21st-century",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Sergey Tkachev",hash:"49cce3f548da548c718c865feb343509",volumeInSeries:9,fullTitle:"Rabies Virus at the Beginning of 21st Century",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",institutionURL:null,country:{name:"Russia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10496",title:"Advanced Studies in the 21st Century Animal Nutrition",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10496.jpg",slug:"advanced-studies-in-the-21st-century-animal-nutrition",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"László Babinszky, Juliana Oliveira and Edson Mauro Santos",hash:"8ffe43a82ac48b309abc3632bbf3efd0",volumeInSeries:8,fullTitle:"Advanced Studies in the 21st Century Animal Nutrition",editors:[{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10497",title:"Canine Genetics, Health and Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10497.jpg",slug:"canine-genetics-health-and-medicine",publishedDate:"June 2nd 2021",editedByType:"Edited by",bookSignature:"Catrin Rutland",hash:"b91512e31ce34032e560362e6cbccc1c",volumeInSeries:7,fullTitle:"Canine Genetics, Health and Medicine",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8545",title:"Animal Reproduction in Veterinary Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8545.jpg",slug:"animal-reproduction-in-veterinary-medicine",publishedDate:"January 20th 2021",editedByType:"Edited by",bookSignature:"Faruk Aral, Rita Payan-Carreira and Miguel Quaresma",hash:"13aaddf5fdbbc78387e77a7da2388bf6",volumeInSeries:6,fullTitle:"Animal Reproduction in Veterinary Medicine",editors:[{id:"25600",title:"Prof.",name:"Faruk",middleName:null,surname:"Aral",slug:"faruk-aral",fullName:"Faruk Aral",profilePictureURL:"https://mts.intechopen.com/storage/users/25600/images/system/25600.jpg",institutionString:"Independent Researcher",institution:{name:"Harran University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9081",title:"Equine Science",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9081.jpg",slug:"equine-science",publishedDate:"September 23rd 2020",editedByType:"Edited by",bookSignature:"Catrin Rutland and Albert Rizvanov",hash:"ac415ef2f5450fa80fdb9cf6cf32cd2d",volumeInSeries:5,fullTitle:"Equine Science",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8460",title:"Reproductive Biology and Technology in Animals",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8460.jpg",slug:"reproductive-biology-and-technology-in-animals",publishedDate:"April 15th 2020",editedByType:"Edited by",bookSignature:"Juan Carlos Gardón Poggi and Katy Satué Ambrojo",hash:"32ef5fe73998dd723d308225d756fa1e",volumeInSeries:4,fullTitle:"Reproductive Biology and Technology in Animals",editors:[{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",institutionString:null,institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Animal Nutrition",value:20,count:2},{group:"subseries",caption:"Animal Reproductive Biology and Technology",value:28,count:3},{group:"subseries",caption:"Animal Science",value:19,count:5}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:3},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:1},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}},{id:"351158",title:"Prof.",name:"David W.",middleName:null,surname:"Anderson",slug:"david-w.-anderson",fullName:"David W. Anderson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Calgary",country:{name:"Canada"}}}]}},subseries:{item:{id:"11",type:"subseries",title:"Cell Physiology",keywords:"Neurodevelopment and Neurodevelopmental Disease, Free Radicals, Tumor Metastasis, Antioxidants, Essential Fatty Acids, Melatonin, Lipid Peroxidation Products and Aging Physiology",scope:"\r\n\tThe integration of tissues and organs throughout the mammalian body, as well as the expression, structure, and function of molecular and cellular components, is essential for modern physiology. The following concerns will be addressed in this Cell Physiology subject, which will consider all organ systems (e.g., brain, heart, lung, liver; gut, kidney, eye) and their interactions: (1) Neurodevelopment and Neurodevelopmental Disease (2) Free Radicals (3) Tumor Metastasis (4) Antioxidants (5) Essential Fatty Acids (6) Melatonin and (7) Lipid Peroxidation Products and Aging Physiology.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11407,editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},publishedBooks:{paginationCount:3,paginationItems:[{type:"book",id:"10859",title:"Data Mining",subtitle:"Concepts and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10859.jpg",slug:"data-mining-concepts-and-applications",publishedDate:"March 30th 2022",editedByType:"Edited by",bookSignature:"Ciza Thomas",hash:"63a4e514e537d3962cf53ef1c6b9d5eb",volumeInSeries:8,fullTitle:"Data Mining - Concepts and Applications",editors:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",slug:"ciza-thomas",fullName:"Ciza Thomas",profilePictureURL:"https://mts.intechopen.com/storage/users/43680/images/system/43680.jpeg",institutionString:null,institution:{name:"Government of Kerala",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10651",title:"Machine Learning",subtitle:"Algorithms, Models and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10651.jpg",slug:"machine-learning-algorithms-models-and-applications",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Jaydip Sen",hash:"6208156401c496e0a4ca5ff4265324cc",volumeInSeries:7,fullTitle:"Machine Learning - Algorithms, Models and Applications",editors:[{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",institutionString:"Praxis Business School",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9963",title:"Advances and Applications in Deep Learning",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9963.jpg",slug:"advances-and-applications-in-deep-learning",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"0d51ba46f22e55cb89140f60d86a071e",volumeInSeries:4,fullTitle:"Advances and Applications in Deep Learning",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"4",title:"Fungal Infectious Diseases",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/287174",hash:"",query:{},params:{id:"287174"},fullPath:"/profiles/287174",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()