More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
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Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
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“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
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Additionally, each book published by IntechOpen contains original content and research findings.
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We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
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Simba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
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IntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
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Since the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\n
Additionally, each book published by IntechOpen contains original content and research findings.
\n\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
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\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5877",leadTitle:null,fullTitle:"Plant Ecology - Traditional Approaches to Recent Trends",title:"Plant Ecology",subtitle:"Traditional Approaches to Recent Trends",reviewType:"peer-reviewed",abstract:"This book is aimed to cover the phylogenetic and functional ecology with special reference to ecological shifts. I hope this book may benefit the students, fellow professors, and resource managers studying plant sciences. Since the topics stated in this book are not new but the issues and technologies mentioned were new to me, I expect that they will be new and equally advanced for the readers too. I encourage the readers to get out into the field to identify plants and to dig out the anthropogenic and social activities effecting plants to come along with the development of plant ecology; to rise and serve the topic of the enormous number of plants facing extinction; and to relish themselves and make some effort to contribute something to the world.",isbn:"978-953-51-3340-7",printIsbn:"978-953-51-3339-1",pdfIsbn:"978-953-51-4660-5",doi:"10.5772/65821",price:119,priceEur:129,priceUsd:155,slug:"plant-ecology-traditional-approaches-to-recent-trends",numberOfPages:200,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"788a981ecedf0d9c0205869788524a80",bookSignature:"Zubaida Yousaf",publishedDate:"September 6th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5877.jpg",numberOfDownloads:16396,numberOfWosCitations:24,numberOfCrossrefCitations:26,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:47,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:97,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 17th 2016",dateEndSecondStepPublish:"November 7th 2016",dateEndThirdStepPublish:"February 3rd 2017",dateEndFourthStepPublish:"May 4th 2017",dateEndFifthStepPublish:"July 3rd 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"196003",title:"Dr.",name:"Zubaida",middleName:null,surname:"Yousaf",slug:"zubaida-yousaf",fullName:"Zubaida Yousaf",profilePictureURL:"https://mts.intechopen.com/storage/users/196003/images/system/196003.jpg",biography:"Dr. Zubaida Yousaf is working as an associate professor in the Department of Botany, Lahore College for Women University, Lahore. She joined this institute in 2009 as an assistant professor. She did her postdoc from South China Botanical Garden, Guangzhou, China, in 2011, funded by TWAS-CAS. She has authored 45 research articles and 4 books and contributed 6 chapters in international editors’ book. She has supervised more than 40 MS thesis, and currently 5 PhD students are working under her supervision.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"331",title:"Forestry Science",slug:"agricultural-and-biological-sciences-ecology-forestry-science"}],chapters:[{id:"56171",title:"Introductory Chapter: Plant Ecology",doi:"10.5772/intechopen.69926",slug:"introductory-chapter-plant-ecology",totalDownloads:1722,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Zubaida Yousaf and Habiba Ramazan",downloadPdfUrl:"/chapter/pdf-download/56171",previewPdfUrl:"/chapter/pdf-preview/56171",authors:[{id:"196003",title:"Dr.",name:"Zubaida",surname:"Yousaf",slug:"zubaida-yousaf",fullName:"Zubaida Yousaf"}],corrections:null},{id:"55621",title:"Detection of Environmental Mutagens Through Plant Bioassays",doi:"10.5772/intechopen.69274",slug:"detection-of-environmental-mutagens-through-plant-bioassays",totalDownloads:1449,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Plants are present in almost all areas of the world and can accumulate many chemical compounds present in the soil, water, and atmosphere. As these chemicals which are potentially mutagenic or carcinogenic are absorbed by the plants sharing the same environment with us, bioassays on plants can be used to detect the presence of environmental hazards. Another reason for selecting plants for assessing adverse effects of these chemicals is the ease of experimentation with plants. Evaluating the effect of a substance on basic plant characteristics such as growth, survival, or reproduction is straightforward and repeatable. Thus, various plant species are commonly utilized as indicators of adverse environmental conditions. This chapter covers the detection of environmental mutagens through plant bioassays, considering the increasing importance of biomonitoring using plants for assessing the mutagenicity of relevant chemicals and industrial waste. From this point of view, a detailed literature search was made on the subject. The genotoxic, cytotoxic, and molecular studies have been investigated and the most useful and important parts and key points of these methods were summarized. This review would be useful for scientists who are planning to conduct research on plant bioassays with different types of methods and chemicals.",signatures:"Özlem Aksoy",downloadPdfUrl:"/chapter/pdf-download/55621",previewPdfUrl:"/chapter/pdf-preview/55621",authors:[{id:"154111",title:"Associate Prof.",name:"Özlem",surname:"Aksoy",slug:"ozlem-aksoy",fullName:"Özlem Aksoy"}],corrections:null},{id:"56182",title:"Ecology of Woody Plants in African Savanna Ecosystems",doi:"10.5772/intechopen.69865",slug:"ecology-of-woody-plants-in-african-savanna-ecosystems",totalDownloads:1693,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Woody plants are key components of African savanna ecosystems as they provide wildlife habitats, offer browsing to ungulates and are also a major source of fuel wood. Disturbance events such as herbivory and fire negatively affect woody plant communities. However, some woody plants respond to disturbance events through resprouting. In savanna ecosystems, woody plants co-occur with grasses and disturbance events such as overgrazing result in the proliferation of woody plants at the expense of the grasses. Therefore, an understanding of the factors that influence woody plants is critical for the better management of African savanna ecosystems. This chapter reviewed our current knowledge of the ecology of woody plants in African savanna ecosystems and examined disturbance events such as herbivory and fire that shape woody plant communities. The role of resprouting as a response to disturbance events and the negative effects of woody plant encroachment on African savannas was also investigated. In addition, the consequences of poor management such as woody plants loss and possible restoration measures were explored. Disturbance events such as herbivory and fire were found to play critical roles in shaping the African savanna ecosystems. Interventions such as restoration have a role to play in restoring the productivity of degraded woody plant communities.",signatures:"Allan Sebata",downloadPdfUrl:"/chapter/pdf-download/56182",previewPdfUrl:"/chapter/pdf-preview/56182",authors:[{id:"143409",title:"Dr.",name:"Allan",surname:"Sebata",slug:"allan-sebata",fullName:"Allan Sebata"}],corrections:null},{id:"55852",title:"Modification in Grassland Ecology under the Influence of Changing Climatic and Land Use Conditions",doi:"10.5772/intechopen.69478",slug:"modification-in-grassland-ecology-under-the-influence-of-changing-climatic-and-land-use-conditions",totalDownloads:1318,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Grasslands are important terrestrial ecosystems in China, which are mainly distributed in arid and semiarid regions. Based on the multiyear field experiments in the semiarid grassland, the effects of land use practices on grassland above- and belowground community characteristics were investigated. In addition, how the annual climate factors regulate grassland productivity was also studied to detect critical periods for grass growth. Results showed that grazing exclusion increased grassland root biomass, root length density and root surface area with declining plant species richness. After grazing exclusion, with perennial bunchgrasses being predominant in root community all the time, proportion of perennial rhizome grasses increased and proportion of perennial forbs declined. Clipping significantly decreased the annual mean soil respiration and its components. The root respiration was more sensitive to clipping than microbial respiration. Temperature increments during the early stage of the growing season (April–May) were positively correlated with aboveground productivity. However, hot and dry summer (June–July) strongly inhibited aboveground productivity. Impacts of drought and heat in August on productivity were negligible. Increased temperature and precipitation during the senescence period (September–October) and a warmer dormancy phase (November–March) were negatively correlated with productivity in the following year, while precipitation during the dormancy period had no detectable effects.",signatures:"Jimin Cheng, Chengcheng Gang, Liang Guo, Wei Li, Jingwei Jin,\nJishuai Su and Lin Wei",downloadPdfUrl:"/chapter/pdf-download/55852",previewPdfUrl:"/chapter/pdf-preview/55852",authors:[{id:"200065",title:"Prof.",name:"Jimin",surname:"Cheng",slug:"jimin-cheng",fullName:"Jimin Cheng"},{id:"204712",title:"Dr.",name:"Chengcheng",surname:"Gang",slug:"chengcheng-gang",fullName:"Chengcheng Gang"},{id:"204713",title:"Dr.",name:"Liang",surname:"Guo",slug:"liang-guo",fullName:"Liang Guo"},{id:"204714",title:"Dr.",name:"Wei",surname:"Li",slug:"wei-li",fullName:"Wei Li"},{id:"204715",title:"Dr.",name:"Jingwei",surname:"Jin",slug:"jingwei-jin",fullName:"Jingwei Jin"},{id:"204716",title:"Mr.",name:"Jishuai",surname:"Su",slug:"jishuai-su",fullName:"Jishuai Su"},{id:"204717",title:"Ms.",name:"Lin",surname:"Wei",slug:"lin-wei",fullName:"Lin Wei"}],corrections:null},{id:"55451",title:"Leaf Ecology and Radiocesium Contamination in Trees/Forests",doi:"10.5772/intechopen.69082",slug:"leaf-ecology-and-radiocesium-contamination-in-trees-forests",totalDownloads:1344,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Nonessential elements enter/accumulate in trees at certain ratios via the same uptake/translocation systems as essential elements. This phenomenon may not only damage the ecosystem but also result in human health problems. As one such nonessential element, the fate of radiocesium in trees has been extensively studied after the nuclear accident at Fukushima in 2011. Here, to better our understanding of the fate of radiocesium in nature and contribute to plan countermeasures, a review based on recent data for the Fukushima accident will be explicated with historical experiences of the global fallout, the Chernobyl accident, and many laboratory studies. In particular, the effects of specific leaf ecology (deciduous and evergreen), types of radiocesium exposure (dry/wet depositions or root uptake), and decomposition of litter on the fate of radiocesium will be precisely described with a specific uptake/translocation system of potassium, which can be recognized as the most possible entrance of radiocesium into trees.",signatures:"Toshihiro Yoshihara",downloadPdfUrl:"/chapter/pdf-download/55451",previewPdfUrl:"/chapter/pdf-preview/55451",authors:[{id:"198703",title:"Prof.",name:"Toshihiro",surname:"Yoshihara",slug:"toshihiro-yoshihara",fullName:"Toshihiro Yoshihara"}],corrections:null},{id:"55309",title:"Plant-Microbe Ecology: Interactions of Plants and Symbiotic Microbial Communities",doi:"10.5772/intechopen.69088",slug:"plant-microbe-ecology-interactions-of-plants-and-symbiotic-microbial-communities",totalDownloads:4647,totalCrossrefCites:11,totalDimensionsCites:27,hasAltmetrics:0,abstract:"Plant community dynamics are driven by the microbial mediation of soil resource partitioning and sharing by the inhibition of other host symbionts or sharing the broadly specific symbiotic fungi. The plant phenotype and ecology can be affected by the impact of the symbiotic microbes on the environment and competition for soil resources.",signatures:"Ying-Ning Ho, Dony Chacko Mathew and Chieh-Chen Huang",downloadPdfUrl:"/chapter/pdf-download/55309",previewPdfUrl:"/chapter/pdf-preview/55309",authors:[{id:"198872",title:"Dr.",name:"Ying-Ning",surname:"Ho",slug:"ying-ning-ho",fullName:"Ying-Ning Ho"},{id:"199676",title:"Prof.",name:"Chieh-Chen",surname:"Huang",slug:"chieh-chen-huang",fullName:"Chieh-Chen Huang"},{id:"201133",title:"Dr.",name:"Dony",surname:"Mathew",slug:"dony-mathew",fullName:"Dony Mathew"}],corrections:null},{id:"55612",title:"Phytosociological Surveys in Weed Science: Old Concept, New Approach",doi:"10.5772/intechopen.69083",slug:"phytosociological-surveys-in-weed-science-old-concept-new-approach",totalDownloads:1505,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Phytosociological surveys have been applied to studies on agroecosystems, especially in relation to weed populations into arable fields. These surveys can indicate trends of variation of the importance of plant populations within a crop, and whether the variations are associated to agricultural practices adopted, which can be further used to support the development of weed management programs. However, to understand the applicability of phytosociological studies for weeds, it is necessary to understand the ecological basis and determine the most appropriate methods to be used when surveying arable fields. Therefore, the aim of the present chapter is to introduce a new approach of phytosociological survey to be used as a tool for the weed science. Throughout the chapter, this new approach is presented in details covering aspects related to methods for sampling and describing weed communities. The following sequence of steps is proposed as the most suitable for a weed phytosociological and association survey: (1) overall infestation; (2) phytosociological tables/graphs; (3) intra-characterization by diversity; (4) inter-characterization and grouping by multivariate analysis; and (5) weeds association through contingency tables.",signatures:"Germani Concenço, Patrícia Menegaz de Farias, Néstor Fabio Alzate\nQuintero, Fábio Schreiber, Leandro Galon, Michely Tomazi, Ivana\nSantos Moisinho, Mariane Camponogara Coradini, William\nChristofari Ceolin and André Andres",downloadPdfUrl:"/chapter/pdf-download/55612",previewPdfUrl:"/chapter/pdf-preview/55612",authors:[{id:"13555",title:"Dr.",name:"Germani",surname:"Concenco",slug:"germani-concenco",fullName:"Germani Concenco"},{id:"160203",title:"Dr.",name:"André",surname:"Andres",slug:"andre-andres",fullName:"André Andres"},{id:"194954",title:"Prof.",name:"Leandro",surname:"Galon",slug:"leandro-galon",fullName:"Leandro Galon"},{id:"200031",title:"Dr.",name:"Fábio",surname:"Schreiber",slug:"fabio-schreiber",fullName:"Fábio Schreiber"},{id:"200547",title:"Dr.",name:"Patricia Menegaz De",surname:"Farias",slug:"patricia-menegaz-de-farias",fullName:"Patricia Menegaz De Farias"},{id:"200548",title:"Dr.",name:"Michely",surname:"Tomazi",slug:"michely-tomazi",fullName:"Michely Tomazi"},{id:"200810",title:"M.Sc.",name:"Néstor",surname:"Alzate-Quintero",slug:"nestor-alzate-quintero",fullName:"Néstor Alzate-Quintero"},{id:"205110",title:"BSc.",name:"Ivana",surname:"Moisinho",slug:"ivana-moisinho",fullName:"Ivana Moisinho"},{id:"205114",title:"Dr.",name:"Mariane",surname:"Coradini",slug:"mariane-coradini",fullName:"Mariane Coradini"},{id:"205115",title:"BSc.",name:"William",surname:"Ceolin",slug:"william-ceolin",fullName:"William Ceolin"}],corrections:null},{id:"55602",title:"Ecological Response to Global Change: Changes in C:N:P Stoichiometry in Environmental Adaptations of Plants",doi:"10.5772/intechopen.69246",slug:"ecological-response-to-global-change-changes-in-c-n-p-stoichiometry-in-environmental-adaptations-of-",totalDownloads:1315,totalCrossrefCites:6,totalDimensionsCites:7,hasAltmetrics:0,abstract:"This review aims to discuss the state of the art of the stoichiometric ratio of foliar nutrients and their impact on adaptive mechanisms of plants to environmental change. Plant stoichiometry is an excellent way to study the multiple ratios across the nutrients in plants and their ecological interactions with the environment. It plays an important role in clarifying the responses of plants to various changes and their adaptation to different environments. However, anthropic activity can change the stoichiometric ratios of plants. In recent decades, anthropic activities have altered the cycle of nitrogen (N), phosphorous (P) and carbon (C) in plants. This is due to excessive fertilizer application, increased global warming and increased atmospheric CO2 emissions, which can quickly limit the increase of production in plants, as they affect the process of acclimatization, which involves a series of changes in plant metabolism at different levels of organization (molecular, biochemical, anatomical and morphological). In this sense, in this new scenario of changes, new plant responses to stoichiometric changes and adaptive processes in the ecosystem have to be reviewed.",signatures:"Renato de Mello Prado and Gilmara Pereira da Silva",downloadPdfUrl:"/chapter/pdf-download/55602",previewPdfUrl:"/chapter/pdf-preview/55602",authors:[{id:"199399",title:"Prof.",name:"Renato",surname:"De Mello Prado",slug:"renato-de-mello-prado",fullName:"Renato De Mello Prado"},{id:"200471",title:"Prof.",name:"Gilmara",surname:"Pereira Da Silva",slug:"gilmara-pereira-da-silva",fullName:"Gilmara Pereira Da Silva"}],corrections:null},{id:"56036",title:"Biogeographical Areas of Hispaniola (Dominican Republic, Republic of Haiti)",doi:"10.5772/intechopen.69081",slug:"biogeographical-areas-of-hispaniola-dominican-republic-republic-of-haiti-",totalDownloads:1404,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:1,abstract:"The island of Hispaniola is located between parallels 17 and 19 N and forms part of the Greater Antilles group in the Caribbean region. It covers an area of 76,484 km2 and has the highest altitudes in the whole Caribbean region. The island consists of two countries: the Dominican Republic and the Republic of Haiti. The flora of both countries has been studied in depth by Liogier and several authors from the Dr. Rafael Ma. Moscoso National Botanical Garden in Santo Domingo; this has enabled us to examine the distribution of 1582 endemic species in 19 areas and several important endemic habitats for conservation: Lepotogono buchii‐Leptochloopsietum virgatae;Crotono astrophori‐Leptochloopsietum virgatae;Melocacto pedenalensi‐Leptochloopsietum virgatae and Solano microphylli‐Leptochloopsietum virgatae pine forests on serpentine belonging to the association Leptogono buchii‐Pinetum occidentalis and high‐mountain pine forests: Dendropemom phycnophylli‐Pinetum occidentalis and Cocotrino scopari‐Pinetum occidentalis. Some dry forest communities are of interest, including Chrysophyllo oliviformi‐Sideroxyletum salicifolii and Zamio debilis‐Metopietum toxiferi. Based on the floristic analysis and the vegetation study, a biogeographical typology for the island, in which we propose 19 biogeographical areas (BA) has been established.",signatures:"Ana Cano Ortiz, Carmelo María Musarella and Eusebio Cano\nCarmona",downloadPdfUrl:"/chapter/pdf-download/56036",previewPdfUrl:"/chapter/pdf-preview/56036",authors:[{id:"87846",title:"Dr.",name:"Eusebio",surname:"Cano Carmona",slug:"eusebio-cano-carmona",fullName:"Eusebio Cano Carmona"},{id:"203697",title:"Dr.",name:"Ana",surname:"Cano Ortiz",slug:"ana-cano-ortiz",fullName:"Ana Cano Ortiz"},{id:"276295",title:"Dr.",name:"Carmelo Maria",surname:"Musarella",slug:"carmelo-maria-musarella",fullName:"Carmelo Maria Musarella"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6880",title:"Recent Advances in Phylogenetics",subtitle:null,isOpenForSubmission:!1,hash:"02cdc1598f4d44c0e449806b889a639b",slug:"recent-advances-in-phylogenetics",bookSignature:"Zubaida Yousaf",coverURL:"https://cdn.intechopen.com/books/images_new/6880.jpg",editedByType:"Edited by",editors:[{id:"196003",title:"Dr.",name:"Zubaida",surname:"Yousaf",slug:"zubaida-yousaf",fullName:"Zubaida Yousaf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2246",title:"Global Perspectives on Sustainable Forest Management",subtitle:null,isOpenForSubmission:!1,hash:"b633fc6fc6a3a8f24dd4c4373fb14cb7",slug:"global-perspectives-on-sustainable-forest-management",bookSignature:"Okia Clement Akais",coverURL:"https://cdn.intechopen.com/books/images_new/2246.jpg",editedByType:"Edited by",editors:[{id:"119660",title:"Dr.",name:"Dr. Clement A.",surname:"Okia",slug:"dr.-clement-a.-okia",fullName:"Dr. Clement A. Okia"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"616",title:"Forest Ecosystems",subtitle:"More than Just Trees",isOpenForSubmission:!1,hash:"00ecaa84de1aa2d7116ab5871b353b82",slug:"forest-ecosystems-more-than-just-trees",bookSignature:"Juan A. Blanco and Yueh-Hsin Lo",coverURL:"https://cdn.intechopen.com/books/images_new/616.jpg",editedByType:"Edited by",editors:[{id:"51995",title:"Dr.",name:"Juan",surname:"Blanco",slug:"juan-blanco",fullName:"Juan Blanco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"617",title:"Sustainable Forest Management",subtitle:"Current Research",isOpenForSubmission:!1,hash:"a8d91cf4745e90f7510e056fd508dc46",slug:"sustainable-forest-management-current-research",bookSignature:"Jorge Martin Garcia and Julio Javier Diez Casero",coverURL:"https://cdn.intechopen.com/books/images_new/617.jpg",editedByType:"Edited by",editors:[{id:"88987",title:"Dr.",name:"Julio J.",surname:"Diez",slug:"julio-j.-diez",fullName:"Julio J. 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1. Introduction
Despite the drop in crude oil prices over the last few years, global efforts to develop alternative renewable energy sources continue to be driven by increasing air pollution and growing energy consumption. Extensive research is therefore being conducted in the field of biofuels [1], which are derived from renewable biological sources. Biodiesel is the main substitute for diesel fuel and can be produced from both edible and non-edible oils. The use of edible oils has generated controversy because of the negative impact on food availability and the environment [2, 3]. As a consequence of these ethical considerations, non-food crops have emerged as a viable alternative for the production of biodiesel [4–6]. However, since non-food crops do not produce sufficient biomatter to feasibly cover the fuel requirements of the world’s transport sector, attention is turning to oleaginous microalgae which are able to produce and accumulate large amounts of fatty acids (FA) in the form of triacylglycerides (TAG) that can be converted into biodiesel through a transesterification reaction [2, 3, 7]. Furthermore, some species of oleaginous microalgae can also produce high-value products such as long-chain polyunsaturated fatty acids (docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids), carbohydrates (cellulose, starch), proteins, and other high-value compounds, such as pigments, antioxidants (i.e., β-carotene, astaxanthin), and vitamins, which may have commercial application in various industrial sectors [2, 3, 8, 9]. In addition to their potential as biological factories, the advantage of these photosynthetic microorganisms is that their simple growing requirements (light, CO2, and nutrients) offer several environmental benefits such as high solar energy conversion efficiency, utilization of saline water, CO2 sequestration from the air and self-purification if coupled with wastewater treatment [10].
Despite the wide range of metabolites able to be synthesized by microalgae, little is known about the regulation of FA and TAG biosynthetic pathways and their storage and turnover in microalgae. In this chapter, we therefore describe recent advances in these fields and possible high-value co-products that could render the production of biodiesel from microalgae more sustainably. Recent studies on the transcriptomics, proteomics, and metabolomics of the above-mentioned pathways are also outlined. Understanding these metabolic pathways will accelerate the availability of biodiesel and other valuable biomolecules obtained from microalgae.
2. FA and TAG biosynthetic pathways in microalgae
Fatty acids are organic acids containing a carboxylic functional group with an aliphatic chain that can be saturated (SFA), monounsaturated (MUFA), or polyunsaturated (PUFA). The number of carbon atoms can vary, generating short-chain, medium-chain, or long-chain FA.
In plants, the FA biosynthetic pathway occurs in the chloroplasts (Figure 1).
Figure 1.
Simplified overview of the pathways involved in FA synthesis in plants. Enzyme abbreviations: ACCase, acetyl-CoA carboxylase; MCAT, malonyl-CoA:Acyl Carrier Protein (ACP) transacylase; KAS, ketoacyl-ACP synthases.
As shown in Figure 1, the first step in the pathway involves the acetyl-CoA carboxylase (ACCase) which catalyzes the formation of malonyl-CoA from acetyl-CoA and bicarbonate [11]. There is evidence suggesting the presence of genes encoding this enzyme (accA and accD) in Chlorella pyrenoidosa. In fact, the transcription of these genes showed to be up-regulated under lipid accumulating conditions [12]. Moreover, a marked increase in the level of acetyl-CoA together with a moderate augmentation of malonyl-CoA and CoA was detected in the green microalgae Chlorella desiccata, Dunaliella tertiolecta, and Chlamydomonas reinhardtii under stress conditions, denoting increased activity of ACCase in these strains [13].
The next step in the FA synthesis is mediated by the malonyl-CoA:Acyl Carrier Protein (ACP) transacylase (MCAT) which transfers the malonyl group from malonyl-CoA to malonyl-ACP [11]. A putative MCAT was identified as a part of the FA biosynthetic pathway in Nannochloropsis oceanica [14]. In Haematococcus pluvialis, the genes encoding ACP were up-regulated under TAG accumulating conditions (high temperature, high salinity, and nitrogen deficiency) together with other genes involved in FA biosynthesis [15]. In addition, proteomic studies on Neochloris oleoabundans revealed an augmented expression of ACP, among other enzymes of the lipid synthesis, under nitrogen starvation [16].
Acyl-ACP is the carbon source or substrate for the elongation of FA. This reaction is catalyzed by enzymes known as ketoacyl-ACP synthases (KASIII, KASI, and KASII). After each condensation, a reduction, dehydration, and second reduction occur. These steps are catalyzed by enzymes known as the FAS complex: beta-ketoacyl-ACP reductase (KAR), hydroxyacyl-ACP dehydrase (HAD), and enoyl-ACP reductase (EAR), respectively [11]. Transcriptome analysis of the diatom Chaetoceros sp. GSL56 helped to identify putative enzymes of the FA synthesis pathway. In addition, replacement of ketoacyl-ACP synthase of Synechococcus 7002 with Chaetoceros ketoacyl-ACP synthase III induced FA synthesis [17]. In line with this, TAG accumulating conditions increased the levels of transcripts for KAS in H. pluvialis [15].
The de novo resulting FA often with 16 or 18 carbon atoms can undergo the action of elongases and desaturases that add carbon or double bonds, respectively [11]. Particularly, desaturases and elongases are being intensively studied to achieve transgenic long-chain PUFA production [18, 19].
Some reports suggest the presence of both enzyme types in microalgae. In the marine microalgae Pavlova sp. and Isochrysis sp., two genes encoding elongases that catalyze the elongation of eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) have been reported [20]. In the diatom Thalassiosira pseudonana, the genes encoding elongases that mediate the formation of DHA from EPA were successfully overexpressed, thus inducing an increase in DHA content [19]. A delta 5 desaturase was also identified, characterized and overexpressed in the diatom Phaeodactylum tricornutum inducing a significant increase in the unsaturated fatty acids [21].
Upon completion of elongation, FAs are transported to the cytoplasm to act as substrates of the acyl transferases involved in the TAG synthesis. TAG are neutral lipids formed by the esterification of one molecule of glycerol with three FAs. Because of their energy-rich acyl chains, they are the dominant form of stored energy in microalgae. Cellular stresses, such as nutrient deprivation (carbon dioxide, nitrogen, silica, and phosphorous), temperature fluctuation, or high light exposure trigger their formation [22–28]. It has been demonstrated that lipid biosynthetic pathways are induced under these conditions to potentiate the lipid storage (30–60% of dry cell weight), and this mechanism is thought to play a role in microalgae adaptation and survival [24, 29–39]. It has further been reported that multiple stressors have no additive effect on lipid accumulation [24, 40].
Data relating to plant FA and TAG metabolism provided the key to identifying possible molecular targets involved in lipid synthesis and accumulation in microalgae [41]. As shown in Figure 2, in plants, the first step of the conventional Kennedy pathway involves the acylation of the glycerol-3-phosphate (G-3-P), catalyzed by the glycerol-3-phosphate acyltransferase (GPAT) to yield lysophosphatidic acid (LPA). GPAT is the rate-limiting step subject to many regulatory controls at the transcriptional and post-transcriptional level and to allosteric mechanisms [42, 43]. Recent studies have revealed the presence of this enzyme in microalgae. In the marine diatom T. pseudonana, a membrane-bound GPAT designated TpGPAT was cloned and characterized. The authors observed that G-3-P was the preferred substrate of TpGPAT [44]. A sequence for GPAT with high homology to that of plants was found in C. reinhardtii, Volvox carteri, Ostreococcus lucimarinus, Ostreococcus tauri, Cyanidioschyzon merolae, and P. tricornutum. As in T. pseudonana, G-3-P and fatty acyl molecules are likely to be the enzyme substrates, as suggested by the residues present in their active sites [45].
Figure 2.
Simplified overview of the pathways involved in TAG synthesis in plants. Enzymes of the conventional Kennedy pathway involved in TAG synthesis and their subcellular localization in plants. Enzyme abbreviations: glycerol-3-phosphate acyltransferase (GPAT); lysophosphatidic acid acyltransferase (LPAAT); phosphatidic acid phosphohydrolase (PAP); diacylglycerol acyltransferase (DAGAT or DGAT). The same enzymes are involved in TAG synthesis in microalgae, but their intracellular localization has not yet been determined.
As described in Figure 2, lysophosphatidic acid acyltransferase (LPAAT) participates in the second step of the Kennedy pathway. This enzyme catalyzes the acylation of the LPA to yield phosphatidic acid (PA) [46]. Candidate LPAATs have been found in some algal genomes including that of H. pluvialis [47, 48], where it has been shown that LPAAT mRNA is induced under high irradiance stress [47]. In addition, it was recently reported that the expression of C. reinhardtii LPAAT (CrLPAAT1) is associated with an increase in lipid synthesis and accumulation under nitrogen starvation [48].
Phosphatidic acid phosphohydrolase (PAP) uses PA as substrate to form diacylglycerol (DAG), a precursor of TAG (Figure 2) [49]. In eukaryotes, PAP enzymes are the members of the evolutionarily conserved lipin protein family whose activity is related to TAG storage [50]. In the green microalga C. reinhardtii, PAP transcripts (named CrPAP2) are induced under stress conditions. In addition, CrPAP2 silencing slightly lowers the lipid content. Thus, in C. reinhardtii, as in other eukaryotes, PAP expression is related to lipid synthesis and accumulation [49].
The last enzyme of the de novo TAG synthesis is acyl-CoA:diacylglycerol acyltransferase (DGAT), which catalyzes the acylation of DAG to yield TAG (Figure 2) [51]. This enzyme employs DAG and acyl-CoA as substrates, so the resulting TAG is formed through an acyl-CoA-dependent pathway [46] and is a key target to increase TAG synthesis and storage through genetic manipulation [52, 53]. In higher plants, three different types of DGATs participate in the formation of TAG: DGAT1, DGAT2, or DGAT3 [54]. Sequences for DGAT1 and DGAT2 isoforms were found in several algal strains [55]. Sequences for DGAT2, but not DAGT1, or DGAT3, were identified in the green microalga O. tauri [56]. DGAT2 was also found in T. pseudonana (TpDGAT2). In addition, the expression of DGAT in a TAG-null yeast mutant restored the synthesis of these neutral lipids [57]. In the oleaginous microalga C. pyrenoidosa grown under stress conditions, a high correlation was found between DGAT and TAG accumulation [58]. Also in N. oceanica IMET1, another oleaginous microalga, seven putative DGAT genes were up-regulated under nitrogen-deficient conditions, when the synthesis of TAG-neutral lipids was significantly increased [59]. In C. reinhardtii dgat1 and dgtt1 to dgtt5 genes encode for DGAT1 and DGAT2, respectively [60, 61]. Increased transcript expression of the genes dgat1 and dgtt1 was detected under stress conditions (less sulfur, phosphorous, iron, zinc, or nitrogen). Once more, the evidence suggests that both DGAT1 and DGAT2 could play a role in TAG synthesis as their expression is induced under TAG-accumulating conditions [62, 63]. In support of this hypothesis, overexpression of a DGAT2 isoform in the marine diatom P. tricornutum stimulated the synthesis of neutral lipids and their accumulation in lipid droplets [64].
As can be observed, much research has focused on the acyl-CoA-dependent reaction catalyzed by DGAT. However, the relative contribution of DGAT1 and DGAT2 isoenzymes to TAG accumulation appears to be species-dependent, so further studies should be performed to gain insight into this aspect.
TAG can be formed by the acyl-CoA-dependent pathway, detailed previously, or through acyl-CoA-independent reactions. Acyl-CoA-independent formation of TAG is mediated by the activities of two types of enzyme: the phospholipid:diacylglycerol acyltransferases (PDAT), which catalyze the formation of TAG using DAG and phosphatidylcholine (PC); and the DAG:DAG transacylases (DGTA) which utilize two molecules of DAG to form TAG and MAG [54, 65].
In fact, in N. oceanica IMET1, it was reported that membrane polar lipids were converted into TAG when the microalgae were grown under nitrogen deficiency [59]. In agreement with this, the gene encoding the acyltransferase PDAT1 was induced under nitrogen starvation in C. reinhardtii. Moreover, TAG content in the C. reinhardtii PDAT-null mutant was 25% lower than in the parent strain. It would thus appear that PDAT has a relevant role in TAG accumulation, stimulating the transacylation pathway in both strains [62]. Furthermore, in C. reinhardtii it was suggested that PDAT functions as a DGTA with acyl hydrolase activity. PDAT might, therefore, mediate membrane polar lipid turnover in a favorable environment whereas under stress conditions it may participate in phospholipid degradation contributing to TAG synthesis [66].
As already mentioned, many aspects of C. reinhartii lipid metabolism have already been characterized, making it the microalga of choice for current purposes [23, 67–73]. Nevertheless, Chlamydomonas is a non-oleaginous strain [23]. Other microalgal species with greater potential to yield biodiesel and other high-value products should therefore be more thoroughly investigated.
3. Transcriptomics, proteomics, and metabolomics
A better understanding of the mechanisms involved in TAG enrichment under stress conditions will help to maximize microalgae productivity. However, many biochemical approaches for elucidating molecular pathways depend on the availability of genomic sequence data [29]. Transcriptomics, proteomics, and metabolomics, however, are able to provide a detailed description of cell transcripts (RNA), proteins and metabolites, respectively while completely bypassing the requirement of genomic information [74, 75].
Transcriptome analysis helped to identify sequences of the enzymes involved in the biosynthesis and catabolism of FA, TAG, and starch in D. tertiolecta, revealing that this strain shares genetic information, at least in terms of the mentioned pathways, with closely related microalgae species such as V. carteri and C. reinhardtii [76]. The transcriptome of N. oleoabundans was also determined. In this case, the authors quantified the differences between nitrogen-replete and nitrogen-limiting culture conditions. Under nitrogen deficiency, N. oleoabundans showed higher levels of transcripts of FA and TAG synthesis pathways and inhibition of the FA β-oxidation pathway, compared to nitrogen-replete culture conditions [29]. In agreement with this finding, in C. vulgaris, transcriptomic [31] and proteomic [77] studies revealed an induction of the enzymes of the FA and TAG synthesis machinery under lipid enrichment conditions. Also, transcription factors associated with these metabolic pathways were augmented under the stress condition [77].
The transcriptome of C. reinhardtii showed that genes involved in FA and TAG metabolic pathways and in membrane remodeling were highly induced under neutral lipid accumulation conditions [78]. In this microalga, proteomic studies revealed an augmented rate of lipid synthesis machinery with a concomitant enhancement in FA and TAG; higher levels of starch than under non-stress conditions were also detected by metabolomic analyses. Metabolic pathways such as nitrogen assimilation, amino acid metabolism, oxidative phosphorylation, glycolysis, TCA cycle, and the Calvin cycle suffered adjustments during C. reinhardtii [79, 80].
As in C. vulgaris, nutrient-deprivation stress in C. reinhardtii, D. tertiolecta, and N. oleoabundans induced the expression of genes involved in FA and TAG synthesis pathways in P. tricornutum [81], Chlorella protothecoides [82], and Tisochrysis lutea [83].
In conclusion, these assembled transcriptomes, proteomes, and metabolomes offer valuable approaches for improving microalgal productivity, providing possible targets for molecular engineering that could enhance microalgae-derived products.
4. Molecular targets for enhancing lipid biosynthesis
Genetic strain modification to improve microalgal productivity and accelerate the industrialization of algal-derived products is a major challenge [84]. Reflecting the fact that enhancement of the FA synthesis pathway had little effect on total lipid content in some plants [85, 86], a growing body of research now focuses on overexpression of the enzymes or heterologous expression of genes involved in the TAG biosynthetic pathway. Table 1 provides an outline of some of the genetic manipulations performed on several microalgal strains, leading to an improvement in their TAG content.
Enzymes overexpressed or heterologously expressed
Organism
Effect on lipid production (changes over control condition)
Lipid droplets (LDs) are cell organelles that are currently the subject of in-depth study in various organisms. These lipid globules not only act as a reservoir of cell carbon and energy, they may also have a role in lipid homeostasis, signaling, trafficking, and interorganelle communications [96, 97]. As previously mentioned, under stress conditions microalgae synthesize TAG and store them as cytoplasmic LDs [22–28], which can vary in size, shape, and function depending on the cell type and the environmental conditions (Figure 3) [98]. In eukaryotic cells, LD structure consists of a TAG-rich hydrophobic core surrounded by surface polar glycerolipids into which proteins of the perilipin (Plin) (animal cells) or oleosin and caleosin (plants) families are embedded [99–102]. In microalgae, LD structure is conserved from eukaryotes but different LD proteins have been identified. The analysis of C. reinhardtii LDs recognized 16 proteins related to lipid metabolism and a major lipid droplet protein (named MLDP) was identified. MLDP silencing increased the size of the LD, without modifying LD TAG content [68]. In the green microalga, Nannochloropsis sp., a hydrophobic lipid droplet surface protein, named LDSP, was identified. The expression of LDSP increased concomitantly with TAG content under oil-accumulating conditions [99]. In H. pluvialis, seven proteins were found to be associated with LDs. The most abundant of these, Haematococcus Oil Globule Protein (HOGP), was homologous to the MLDP of C. reinhardtii and its expression was induced under TAG accumulating conditions [103]. LD-associated proteins may also help in the accumulation of TAG in the green microalga Myrmecia incisa [104]. Moreover, LDs from C. reinhardtii showed the presence of enzymes involved in TAG synthesis (GPAT, and PDAT) and in sterol synthesis, lipid signaling, and trafficking [69]. Further in-depth research should be able to determine the proteins associated with LDs and their role in TAG metabolism in microalgae.
Figure 3.
Schematic representation of a cytoplasmic lipid droplet (LD) from microalgae.
In the oleaginous diatom Fistulifera sp., two proteins located in the oil bodies were also detected in the endoplasmic reticulum (ER), suggesting that oil bodies might originate in the ER [105]. The same authors found a signal sequence typical of ER localization in an LD protein called diatom-oleosome-associated-protein 1 (DOAP1) in Fistulifera solaris JPCC DA0580 [106]. Related to these findings, the induction of ER stress leads to LD formation in C. reinhardtii and C. vulgaris [107]. In addition, LDs from C. reinhardtii were associated not only with the ER membrane but also with the outer membrane of the chloroplasts [108]. Available data therefore suggest that in microalgae, cytoplasmic LDs are produced in the ER. However, additional studies are required to arrive at a better understanding of the mechanism of LD formation in the ER, and to determine whether chloroplasts play a role in this process.
6. TAG degradation pathways in microalgae
As previously mentioned, the economic feasibility of using microalgae as a source of FA for biodiesel depends to a great extent on improvements in the production process, one of the most significant challenges being to increase lipid yields. The selection of oleaginous strains and the search for different culture strategies to increase lipid biosynthesis constitute viable approaches; blocking the competing pathways of carbohydrate formation may be another. However, both the approaches give rise to a decrease in strain growth [22]. Lipid catabolism has largely been ignored as a relevant pathway for engineering, despite being a competing pathway to lipid biogenesis [109]. However, lipases were identified in C. reinhardtii [66, 72, 73] and T. pseudonana [110]. In the case of C. reinhardtii, CrLIP1 could restore the lipase activity in a Saccharomyces cerevisiae lipase-null strain. In addition, C. reinhardtii TAG content decreased with increasing expression of CrLIP1 under stress conditions, hydrolyzing mainly DAG and polar lipids [72]. In agreement with this, a galactoglycerolipid lipase was found in C. reinhardtii. The main substrates of the enzyme are galactoglycerolipids and the main products are FAs employed for TAG synthesis [74]. In C. reinhardtii, phospholipid:diacylglycerol acyltransferase (PDAT) demonstrated both transacylation and acyl hydrolase activities, and could mediate membrane lipid turnover and TAG synthesis [66]. The activity of a multifunctional lipase/phospholipase/acyltransferase of T. pseudonana lowered lipid content under both normal and stress conditions [110]. A single gene for PDAT was identified in H. pluvialis, though no functional analysis was performed for the gene in this strain [47]. Further studies are required to gain insight into the molecular mechanisms involved in TAG degradation, which could be the key to increased lipid yields in microalgae.
7. Microalgae-based biorefineries
In the context of improving the economic feasibility of microalgae-based biodiesel, a closer look should be taken at the large amounts of TAG produced in some oleaginous microalgae alongside high-value products such as carbohydrates (cellulose and starch); proteins and other high-value compounds like pigments, antioxidants (i.e., β-carotene, astaxanthin), and vitamins [2, 3, 8, 9], all of which may have commercial application in different industrial sectors. Some potentially high-value products found in microalgae are described in Table 2.
Recent advances in microalgal-derived high-value products.
8. Conclusion
Oleaginous microalgae grown under stress conditions can synthesize and accumulate large quantities of FA, mainly in the form of TAG, which can then be converted into biodiesel. Although microalgae constitute a promising source of clean energy, knowledge gaps continue to abound in almost all aspects of FA and TAG metabolism for these microorganisms, including the precise identity of enzymatic machinery, the relative contributions of each enzyme and their precise regulation. Further studies are therefore required to establish the exact metabolic pathways involved in FA and TAG synthesis, accumulation, and degradation in order to develop genetic engineering strategies to obtain microalgal strains with improved capacity to convert their biomass into TAG and other valuable co-products.
Acknowledgments
The authors are grateful for research funds provided by the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina (CONICET); Agencia Nacional de Promoción Científica y Tecnológica, PICTs 2014-0893, 2013-0987, and 2015-0800; and the Secretaría de Ciencia y Tecnología de la Universidad Nacional del Sur, PGIs 24/B226 and 24/B196. Paola Scodelaro Bilbao, Gabriela Salvador and Patricia Leonardi are Research Members of CONICET.
\n',keywords:"fatty acids, triacylglycerides, lipid metabolism, microalgae",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/54316.pdf",chapterXML:"https://mts.intechopen.com/source/xml/54316.xml",downloadPdfUrl:"/chapter/pdf-download/54316",previewPdfUrl:"/chapter/pdf-preview/54316",totalDownloads:2731,totalViews:789,totalCrossrefCites:5,totalDimensionsCites:7,totalAltmetricsMentions:0,impactScore:2,impactScorePercentile:79,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:"September 27th 2016",dateReviewed:"January 16th 2017",datePrePublished:null,datePublished:"June 21st 2017",dateFinished:"March 5th 2017",readingETA:"0",abstract:"Microalgae were originally considered as sources of long-chain polyunsaturated fatty acids (PUFAs), mainly for aquaculture purposes. However, based on the fact that their fatty acids (FA), stored as triacylglycerides (TAG), can be converted into biodiesel via a transesterification reaction, several microalgal species have emerged over the last decade as promising feedstocks for biofuel production. Elucidation of microalgae FA and TAG metabolic pathways is therefore becoming a cutting-edge field for developing transgenic algal strains with improved lipid accumulation ability. Furthermore, many of the biomolecules produced by microalgae can also be exploited. In this chapter, we describe recent advances in the field of FA and TAG pathways in microalgae, focusing in particular on the enzymes involved in FA and TAG synthesis, their accumulation in lipid droplets, and their degradation. Mention is made of potentially high-value products that can be obtained from microalgae, and possible molecular targets for enhancing FA and TAG production are outlined. A summary is provided of transcriptomics, proteomics, and metabolomics of the above-mentioned pathways in microalgae. Understanding the relation between anabolic and catabolic lipid enzyme pathways will provide new insights into biodiesel production and other valuable biomolecules obtained from microalgae.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/54316",risUrl:"/chapter/ris/54316",book:{id:"5769",slug:"fatty-acids"},signatures:"Paola Scodelaro Bilbao, Gabriela A. Salvador and Patricia I. Leonardi",authors:[{id:"50699",title:"Dr.",name:"Patricia",middleName:"Ines",surname:"Leonardi",fullName:"Patricia Leonardi",slug:"patricia-leonardi",email:"leonardi@uns.edu.ar",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universidad Nacional del Sur",institutionURL:null,country:{name:"Argentina"}}},{id:"196637",title:"Dr.",name:"Paola",middleName:null,surname:"Scodelaro Bilbao",fullName:"Paola Scodelaro Bilbao",slug:"paola-scodelaro-bilbao",email:"pscodela@criba.edu.ar",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"196638",title:"Dr.",name:"Gabriela",middleName:null,surname:"Salvador",fullName:"Gabriela Salvador",slug:"gabriela-salvador",email:"salvador@criba.edu.ar",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. FA and TAG biosynthetic pathways in microalgae",level:"1"},{id:"sec_3",title:"3. Transcriptomics, proteomics, and metabolomics",level:"1"},{id:"sec_4",title:"4. Molecular targets for enhancing lipid biosynthesis",level:"1"},{id:"sec_5",title:"5. TAG-accumulation in lipid droplets",level:"1"},{id:"sec_6",title:"6. TAG degradation pathways in microalgae",level:"1"},{id:"sec_7",title:"7. Microalgae-based biorefineries",level:"1"},{id:"sec_8",title:"8. Conclusion",level:"1"},{id:"sec_9",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'Misra N, Kumar Panda P, Kumar Parida B, Kanta Mishra B. Phylogenomic study of lipid genes involved in microalgal biofuel production: candidate gene mining and metabolic pathway analyses. Evol Bioinform Online. 2012; 8: 545-564. doi: 10.4137/EBO.S10159.'},{id:"B2",body:'Brennan L, Owende P. Biofuels from microalgae: a review of technologies for production, processing, and extractions of biofuels and co-products. Renew Sust Energy Rev. 2010; 14: 557-577. doi: 10.1016/j.rser.2009.10.009.'},{id:"B3",body:'Mata TM, Martinsa AA, Caetano NS. Microalgae for biodiesel production and other applications: a review. Renew Sust Energy Rev. 2012; 14: 217-232. doi: 10.1016/j.rser.2009.07.020.'},{id:"B4",body:'Foild N, Foild G, Sánchez M, Mittelbach M, Hackel S. J. curcas L. as a source for the production of biofuel in Nicaragua. Bioresour Technol. 1996; 58: 77-82.'},{id:"B5",body:'Rashid U, Anwar F, Moser BR, Knothe G. Moringa oleifera oil: a possible source of biodiesel. Bioresour Technol. 2008; 99: 8175-8179. doi: 10.1016/j.biortech.2008.03.066.'},{id:"B6",body:'Ahmad M, Zafar M, Azam A, Sadia H, Khan MA, Sultana S. Techno-economic aspects of biodiesel production and characterization. Energy sources. 2011; 6: 166-177.'},{id:"B7",body:'Yu WL, Ansari W, Schoepp NG, Hannon MJ, Mayfield SP, Burkart MD. Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae. Microb Cell Fact. 2011; 10: 91. doi: 10.1186/1475-2859-10-91.'},{id:"B8",body:'Williams PJ le B, Laurens LML. Microalgae as biodiesel and biomass feedstocks: review and analysis of the biochemistry, energetics and economics. Energy Environ. Sci. 2010; 3: 554-590. doi: 10.1039/B924978H.'},{id:"B9",body:'Borowitzka MA. High-value products from microalgae—their development and commercialization. J Appl Phycol. 2013; 25: 743-756. doi:10.1007/s10811-013-9983-9.'},{id:"B10",body:'Lam MK, Lee KT. Microalgae biofuels: a critical review of issues, problems and the way forward. Biotechnol Adv. 2012; 30: 673-690. doi: 10.1016/j.biotechadv.2011.11.008.'},{id:"B11",body:'Brown AP, Slabas AR, Rafferty JB. Fatty acid biosynthesis in plants-metabolic pathways, structure and organization. Lipids in Photosynthesis. 2010; 30: 11-34. doi: 10.1007/978-90-481-2863-1_2.'},{id:"B12",body:'Fan J, Cui Y, Wan M, Wang W, Li Y. Lipid accumulation and biosynthesis genes response of the oleaginous Chlorella pyrenoidosa under three nutrition stressors. Biotech Biofuels. 2014; 7: 17. doi: 10.1186/1754-6834-7-17.'},{id:"B13",body:'Avidan O, Brandis A, Rogachev I, Pick U. Enhanced acetyl-CoA production is associated with increased triglyceride accumulation in the green alga Chlorella desiccate. J Exp Botany. 2015; 66: 1-11. doi:10.1093/jxb/erv166.'},{id:"B14",body:'Chen JW, Liu W-J, Hu D-X, Wang X, Balamurugan S, Alimujiang A, Yang W-D, Liu J-S, Li H-Y. Identification of a malonyl CoA-acyl carrier protein transacylase and its regulatory role in fatty acid biosynthesis in oleaginous microalga Nannochloropsis oceanica. Biotech Appl Biochem. 2016. doi: 10.1002/bab.1531.'},{id:"B15",body:'Lei A, Chen H, Shen G, Hu Z, Chen L, Wang J. Expression of fatty acid synthesis genes and fatty acid accumulation in Haematococcus pluvialis under different stressors. Biotechnol Biofuels. 2012; 5: 18. doi: 10.1186/1754-6834-5-18.'},{id:"B16",body:'Morales-Sánchez D, Kyndtb J, Ogdenc K, Martinez A. Toward an understanding of lipid and starch accumulation in microalgae: a proteomic study of Neochloris oleoabundans cultivated under N-limited heterotrophic conditions. Algal Res. 2016; 20: 22-34. doi: 10.1016/j.algal.2016.09.006.'},{id:"B17",body:'Gu H, Jinkerson RE, Davies FK, Sisson LA, Schneider PE, Posewitz MC. Modulation of medium-chain fatty acid synthesis in Synechococcus sp. PCC 7002 by replacing FabH with a Chaetoceros Ketoacyl-ACP synthase. Front Plant Sci. 2016; 7: 690. doi: 10.3389/fpls.2016.00690.'},{id:"B18",body:'Peng KT, Zheng CN, Xue J, Chen XY, Yang WD, Liu JS, Bai W, Li HY. Delta 5 fatty acid desaturase upregulates the synthesis of polyunsaturated fatty acids in the marine diatom Phaeodactylum tricornutum. J Agric Food Chem. 2014; 62: 8773-8776. doi: 10.1021/jf5031086.'},{id:"B19",body:'Petrie JR, Liu Q, Mackenzie AM, Shrestha P, Mansour MP, Robert SS, Frampton DF, Blackburn SI, Nichols PD, Singh SP. Isolation and characterisation of a high-efficiency desaturase and elongases from microalgae for transgenic LC-PUFA production. Mar Biotechnol. 2010; 12: 430-438. doi: 10.1007/s10126-009-9230-1.'},{id:"B20",body:'Pereira SL, Leonard AE, Huang YS, Chuang LT, Mukerji P. Identification of two novel microalgal enzymes involved in the conversion of the omega3-fatty acid, eicosapentaenoic acid, into docosahexaenoic acid. Biochem J. 2004; 384: 357-366.'},{id:"B21",body:'Cook O, Hildebrand M. Enhancing LC-PUFA production in Thalassiosira pseudonana by overexpressing the endogenous fatty acid elongase genes. J Appl Phycol. 2016; 28: 897-905.'},{id:"B22",body:'Hu Q, Sommerfeld M, Jarvis E, Ghirardi M, Posewitz M, Seibert M, Darzins A. Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances. Plant J. 2008; 54: 621-639. doi: 10.1111/j.1365-313X.2008.03492.x.'},{id:"B23",body:'Liu B, Benning C. Lipid metabolism in microalgae distinguishes itself. Curr Opin Biotechnol. 2013; 24: 300-309. doi: 10.1016/j.copbio.2012.08.008.'},{id:"B24",body:'Damiani MC, Popovich CA, Constenla D, Leonardi PI. Lipid analysis in Haematococcus pluvialis to assess its potential use as a biodiesel feedstock. Bioresour Technol. 2010; 101: 3801-3807. doi: 10.1016/j.biortech.2009.12.136.'},{id:"B25",body:'Popovich CA, Damiani C, Constenla D, Leonardi PI. Lipid quality of Skeletonema costatum and Navicula gregaria from South Atlantic Coast (Argentina): evaluation of its suitability as biodiesel feedstock. J Appl Phycol. 2012; 24: 1-10. doi:10.1007/s10811-010-9639-y.'},{id:"B26",body:'Popovich CA, Damiani MC, Constenla D, Martínez AM, Freije H, Giovanardi M, Pancaldi S, Leonardi PI. Neochloris oleoabundans grown in enriched natural seawater for biodiesel feedstock: evaluation of its growth and biochemical composition. Bioresour Technol. 2012; 114: 287-293. doi: 10.1016/j.biortech.2012.02.121.'},{id:"B27",body:'Bongiovani N, Popovich C, Martínez A, Freije H, Constenla D, Leonardi PI. In vivo measurements to estimate culture status and neutral lipid accumulation in Nannochloropsis oculata CCALA 978: implications for biodiesel oil studies. Algological Studies. 2013; 142: 3-16 doi: 10.1127/1864-1318/2013/0104.'},{id:"B28",body:'Martín L, Popovich C, Martinez A, Damiani C, Leonardi PI. Oil assessment of Halamphora coffeaeformis diatom growing in a hybrid two-stage system for biodiesel production. Renewable Energy. 2016; 92: 127-135. doi: 10.1016/j.renene.2016.01.078'},{id:"B29",body:'Rismani-Yazdi H, Haznedaroglu BZ, Hsin C, Peccia J. Transcriptomic analysis of the oleaginous microalga Neochloris oleoabundans reveals metabolic insights into triacylglyceride accumulation. Biotechnol Biofuels. 2012; 5: 74. doi: 10.1186/1754-6834-5-74.'},{id:"B30",body:'Yu ET, Zendejas FJ, Lane PD, Gaucher S, Simmons BA, Lane TW. Triacylglycerol accumulation and profiling in the model diatoms Thalassiosira pseudonana and Phaeodactylum tricornutum (Bacillariophyceae) during starvation. J Appl Phycol. 2009; 21: 669-681. doi: 10.1007/s10811-008-9400-y.'},{id:"B31",body:'Guarnieri MT, Nag A, Smolinski SL, Darzins A, Seibert M, et al. Examination of triacylglycerol biosynthetic pathways via de novo transcriptomic and proteomic analyses in an unsequenced microalga. PLoS One. 2011; 6: e25851. doi: 10.1371/journal.pone.0025851.'},{id:"B32",body:'Pal D, Khozin-Goldberg I, Cohen Z, Boussiba S. The effect of light, salinity, and nitrogen availability on lipid production by Nannochloropsis sp. Appl Microbiol Biotechnol. 2011; 90: 1429-1441. doi:10.1007/s00253-011-3170-1.'},{id:"B33",body:'Tang H, Chen M, Garcia ME, Abunasser N, Ng KY, Salley SO. Culture of microalgae Chlorella minutissima for biodiesel feedstock production. Biotechnol Bioeng. 2011; 108: 2280-2287. doi: 10.1002/bit.23160.'},{id:"B34",body:'Breuer G, Lamers PP, Martens DE, Draaisma RB, Wijffels RH. Effect of light intensity, pH, and temperature on triacylglycerol (TAG) accumulation induced by nitrogen starvation in Scenedesmus obliquus. Bioresour Technol. 2013; 143: 1-9. doi: 10.1016/j.biortech.2013.05.105.'},{id:"B35",body:'Gong Y, Guo X, Wan X, Liang Z, Jiang M. Triacylglycerol accumulation and change in fatty acid content of four marine oleaginous microalgae under nutrient limitation and at different culture ages. J Basic Microbiol. 2013; 53: 29-36. doi: 10.1002/jobm.201100487.'},{id:"B36",body:'Yu SY, Li H, Tong M, Ouyang LL, Zhou ZG. Identification of a Δ6 fatty acid elongase gene for arachidonic acid biosynthesis localized to the endoplasmic reticulum in the green microalga Myrmecia incisa Reisigl. Gene. 2012; 493: 219-227. doi: 10.1016/j.gene.2011.11.053.'},{id:"B37",body:'Aguirre AM, Bassi A. Investigation of biomass concentration, lipid production, and cellulose content in Chlorella vulgaris cultures using response surface methodology. Biotechnol Bioeng. 2013; 110: 2114-2122. doi: 10.1002/bit.24871.'},{id:"B38",body:'Simionato D, Block MA, La Rocca N, Jouhet J, Maréchal E, Finazzi G, Morosinotto T. The response of Nannochloropsis gaditana to nitrogen starvation includes de novo biosynthesis of triacylglycerols, a decrease of chloroplast galactolipids, and reorganization of the photosynthetic apparatus. Eukaryot Cell. 2013; 12: 665-676. doi: 10.1128/EC.00363-12.'},{id:"B39",body:'La Russa M, Bogen C, Uhmeyer A, Doebbe A, Filippone E, Kruse O, Mussgnug JH. Functional analysis of three type-2 DGAT homologue genes for triacylglycerol production in the green microalga Chlamydomonas reinhardtii. J Biotechnol. 2012; 162: 13-20. doi: 10.1016/j.jbiotec.2012.04.006.'},{id:"B40",body:'Roleda MY, Slocombe SP, Leakey RJ, Day JG, Bell EM, Stanley MS. Effects of temperature and nutrient regimes on biomass and lipid production by six oleaginous microalgae in batch culture employing a two-phase cultivation strategy. Bioresour Technol. 2013; 129: 439-449. doi: 10.1016/j.biortech.2012.11.043.'},{id:"B41",body:'Adarme-Vega TC, Lim DKY, Timmins M, Vernen F, Li Y, Schenk PM. Microalgal biofactories: a promising approach towards sustainable omega-3 fatty acid production. Microb Cell Fact. 2012; 11: 96. doi: 10.1186/1475-2859-11-96.'},{id:"B42",body:'Coleman RA, Lee DP. Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res. 2004; 43: 134-176. doi: 10.1016/S0163-7827(03)00051-1.'},{id:"B43",body:'Courchesne NMD, Parisien A, Wang B, Lan CQ. Enhancement of lipid production using biochemical, genetic and transcription factor engineering approaches. J Biotechnol. 2009; 141: 31-41. doi: 10.1016/j.jbiotec.2009.02.018.'},{id:"B44",body:'Xu J, Zheng Z, Zou J. A membrane-bound glycerol-3-phosphate acyltransferase from Thalassiosira pseudonana regulates acyl composition of glycerolipids. Botany. 2009; 87: 544-551. doi: 10.1139/B08-145.'},{id:"B45",body:'Misra N, Panda PK, Parida BK. Agrigenomics for microalgal biofuel production: an overview of various bioinformatics resources and recent studies to link OMICS to bioenergy and bioeconomy. OMICS. 2013; 17: 537-549. doi: 10.1089/omi.2013.0025.'},{id:"B46",body:'Chapman KD, Ohlrogge JB. Compartmentation of triacylglycerol accumulation in plants. J Biol Chem. 2012; 287: 2288-2294. doi: 10.1074/jbc.R111.290072.'},{id:"B47",body:'Gwak Y, Hwang YS, Wang B, Kim M, Jeong J, Lee CG, Hu Q, Han D, Jin E. Comparative analyses of lipidomes and transcriptomes reveal a concerted action of multiple defensive systems against photooxidative stress in Haematococcus pluvialis. J Exp Bot. 2014; 65: 4317-4334. doi: 10.1093/jxb/eru206.'},{id:"B48",body:'Yamaoka Y, Achard D, Jang S, Legéret B, Kamisuki S, Ko D, Schulz-Raffelt M, Kim Y, Song WY, Nishida I, Li-Beisson Y, Lee Y. Identification of a Chlamydomonas plastidial 2-lysophosphatidic acid acyltransferase and its use to engineer microalgae with increased oil content. Plant Biotechnol J. 2016; 14: 2158-2167. doi: 10.1111/pbi.12572.'},{id:"B49",body:'Deng XD, Cai JJ, Fei XW. Involvement of phosphatidate phosphatase in the biosynthesis of triacylglycerols in Chlamydomonas reinhardtii. J Zhejiang Univ Sci B. 2013; 14: 1121-1131. doi: 10.1631/jzus.B1300180.'},{id:"B50",body:'Csaki LS, Dwyer JR, Fong LG, Tontonoz P, Young SG, Reue K. Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Progr Lipid Res. 2013; 52: 305-316. doi: 10.1016/j.plipres.2013.04.001.'},{id:"B51",body:'Radakovits R, Jinkerson RE, Darzins A, Posewitz MC. Genetic engineering of algae for enhanced biofuel production. Eukaryot Cell. 2010; 9: 486-501. doi: 10.1128/EC.00364-09.'},{id:"B52",body:'Taylor DC, Katavic V, Zou J, MacKenzie SL, Keller WA, An J, Friesen W, Barton DL, Pedersen KK, Giblin EM, et al. Field testing of transgenic rapeseed cv. Hero transformed with a yeast sn-2 acyltransferase results in increased oil content, erucic acid content and seed yield. Mol Breed. 2002; 8: 317-322. DOI: 10.1023/A:1015234401080.'},{id:"B53",body:'Lardizabal KD, Thompson GA, Hawkins D. Diacylglycerol acyl transferase proteins. In Official Gazette of the United States Patent and Trademark Office Patents Edited by: Office TUSPaT. USA, 2006.'},{id:"B54",body:'Lung SC, Weselake RJ. Diacylglycerol acyltransferase: a key mediator of plant triacylglycerol synthesis. Lipids. 2006; 41: 1073-1088.'},{id:"B55",body:'Chen JE, Smith AG. A look at diacylglycerol acyltransferases (DGATs) in algae. J Biotechnol. 2012; 162: 28-39. doi: 10.1016/j.jbiotec.2012.05.009.'},{id:"B56",body:'Wagner M, Hoppe K, Czabany T, Heilmann M, Daumb G, Feussner I, Fulda M. Identification and characterization of an acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) gene from the microalga O. tauri. Plant Physiol Biochem. 2010; 48: 407-416. doi: 10.1016/j.plaphy.2010.03.008.'},{id:"B57",body:'Xu J, Kazachkov M, Jia Y, Zheng Z, Zou J. Expression of a type 2 diacylglycerol acyltransferase from Thalassiosira pseudonana in yeast leads to incorporation of docosahexaenoic acid β-oxidation intermediates into triacylglycerol. FEBS J. 2013; 280: 6162-6172. doi: 10.1111/febs.12537.'},{id:"B58",body:'Fan J, Cui Y, Wan M, Wang W, Li Y. Lipid accumulation and biosynthesis genes response of the oleaginous Chlorella pyrenoidosa under three nutrition stressors. Biotechnol Biofuels. 2014; 7: 17. doi: 10.1186/1754-6834-7-17.'},{id:"B59",body:'Xiao Y, Zhang J, Cui J, Feng Y, Cui Q. Metabolic profiles of Nannochloropsis oceanica IMET1 under nitrogen-deficiency stress. Bioresour Technol. 2013; 130: 731-738. doi: 10.1016/j.biortech.2012.11.116.'},{id:"B60",body:'Miller R, Wu G, Deshpande RR, Vieler A, Gärtner K, Li X, Moellering ER, Zäuner S, Cornish AJ, Liu B, Bullard B, Sears BB, Kuo M-H, Hegg EL, Shachar-Hill Y, Shiu S-H, Benning C. Changes in transcript abundance in Chlamydomonas reinhardtii following nitrogen deprivation predict diversion of metabolism. Plant Physiol. 2010; 154: 1737-1752. doi: 10.1104/pp.110.165159.'},{id:"B61",body:'Msanne J, Xu D, Konda AR, Casas-Mollano JA, Awada T, Cahoon EB, Cerutti H. Metabolic and gene expression changes triggered by nitrogen deprivation in the photoautotrophically grown microalgae Chlamydomonas reinhardtii and Coccomyxa sp. C-169. Phytochemistry. 2012; 75: 50-59. doi: 10.1016/j.phytochem.2011.12.007.'},{id:"B62",body:'Boyle NR, Page MD, Liu B, Blaby IK, Casero D, Kropat J, Cokus SJ, Hong-Hermesdorf A, Shaw J, Karpowicz SJ, Gallaher SD, Johnson S, Benning C, Pellegrini M, Grossman A, Merchant SS. Three acyltransferases and nitrogen-responsive regulator are implicated in nitrogen starvation-induced triacylglycerol accumulation in Chlamydomonas. J Biol Chem. 2012; 287: 15811-1525. doi: 10.1074/jbc.M111.334052.'},{id:"B63",body:'Guihéneuf F, Leu S, Zarka A, Khozin-Goldberg I, Khalilov I, Boussiba S. Cloning and molecular characterization of a novel acyl-CoA:diacylglycerol acyltransferase 1-like gene (PtDGAT1) from the diatom Phaeodactylum tricornutum. FEBS J. 2011: 278: 3651-3666. doi: 10.1111/j.1742-4658.2011.08284.x.'},{id:"B64",body:'Niu YF, Zhang MH, Li DW, Yang WD, Liu JS, Bai WB, Li HY. Improvement of neutral lipid and polyunsaturated fatty acid biosynthesis by overexpressing a type 2 diacylglycerol acyltransferase in marine diatom Phaeodactylum tricornutum. Mar Drugs. 2013; 11: 4558-4569. doi: 10.3390/md11114558.'},{id:"B65",body:'Dahlqvist A, Stahl U, Lenman M, Banas A, Lee M, Sandager L, Ronne H, Stymne S. Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants. Proc Natl Acad Sci USA. 2000; 97: 6487-6492. doi: 10.1073/pnas.120067297.'},{id:"B66",body:'Yoon K, Han D, Li Y, Sommerfeld M, Hu Q. Phospholipid:diacylglycerol acyltransferase is a multifunctional enzyme involved in membrane lipid turnover and degradation while synthesizing triacylglycerol in the unicellular green microalga Chlamydomonas reinhardtii. Plant Cell. 2012; 24: 3708-3724. doi: 10.1105/tpc.112.100701.'},{id:"B67",body:'La Russa M, Bogen C, Uhmeyer A, Doebbe A, Filippone E, Kruse O, Mussgnug JH. Functional analysis of three type-2 DGAT homologue genes for triacylglycerol production in the green microalga Chlamydomonas reinhardtii. J Biotechnol. 2012; 162: 13-20. doi: 10.1016/j.jbiotec.2012.04.006.'},{id:"B68",body:'Moellering ER, Benning C. RNA interference silencing of a major lipid droplet protein affects lipid droplet size in Chlamydomonas reinhardtii. Eukaryot Cell. 2010; 9: 97-106. doi: 10.1128/EC.00203-09.'},{id:"B69",body:'Nguyen HM, Baudet M, Cuiné S, Adriano JM, Barthe D, Billon E, Bruley C, Beisson F, Peltier G, Ferro M, Li-Beisson Y. Proteomic profiling of oil bodies isolated from the unicellular green microalga Chlamydomonas reinhardtii: with focus on proteins involved in lipid metabolism. Proteomics. 2011; 11: 4266-4273. doi: 10.1002/pmic.201100114.'},{id:"B70",body:'Kato N, Dong T, Bailey M, Lum T, Ingram D. Triacylglycerol mobilization is suppressed by brefeldin A in Chlamydomonas reinhardtii. Plant Cell Physiol. 2013; 54: 1585-1599. doi:10.1093/pcp/pct103.'},{id:"B71",body:'Merchant SS, Kropat J, Liu B, Shaw J, Warakanont J. TAG, you\'re it! Chlamydomonas as a reference organism for understanding algal triacylglycerol accumulation. Curr Opin Biotechnol. 2012; 23: 352-363. doi: 10.1016/j.copbio.2011.12.001.'},{id:"B72",body:'Li X, Benning C, Kuoc M-H. Rapid Triacylglycerol Turnover in Chlamydomonas reinhardtii Requires a Lipase with Broad Substrate. Eukaryot Cell. 2012; 11: 1451-1462. doi: 10.1128/EC.00268-12.'},{id:"B73",body:'Li X, Moellering ER, Liu B, Johnny C, Fedewa M, Sears BB, Kuo MH, Benning C. A galactoglycerolipid lipase is required for triacylglycerol accumulation and survival following nitrogen deprivation in Chlamydomonas reinhardtii. Plant Cell. 2012; 24: 4670-4686. doi: 10.1105/tpc.112.105106.'},{id:"B74",body:'Guarnieri MT, Pienkos PT. Algal omics: unlocking bioproduct diversity in algae cell factories. Photosynth Res. 2014; 123: 255-263. doi: 10.1007/s11120-014-9989-4.'},{id:"B75",body:'Jamers A, Blust R, De Coen W. Omics in algae: paving the way for a systems biological understanding of algal stress phenomena? Aquat Toxicol. 2009; 92: 114-121. doi: 10.1016/j.aquatox.2009.02.012.'},{id:"B76",body:'Rismani-Yazdi H, Haznedaroglu BZ, Bibby K, Peccia J. Transcriptome sequencing and annotation of the microalgae Dunaliella tertiolecta: pathway description and gene discovery for production of next-generation biofuels. BMC Genomics. 2011; 12: 148. doi: 10.1186/1471-2164-12-148.'},{id:"B77",body:'Guarnieri MT, Nag A, Yang S, Pienkos PT. Proteomic analysis of Chlorella vulgaris: potential targets for enhanced lipid accumulation. J Proteomics. 2013; 93: 245-253. doi: 10.1016/j.jprot.2013.05.025.'},{id:"B78",body:'Lv H, Qu G, Qi X, Lu L, Tian C, Ma Y. Transcriptome analysis of Chlamydomonas reinhardtii during the process of lipid accumulation. Genomics. 2013; 101: 229-237. doi: 10.1016/j.ygeno.2013.01.004.'},{id:"B79",body:'Wase N, Black PN, Stanley BA, DiRusso CC. Integrated quantitative analysis of nitrogen stress response in Chlamydomonas reinhardtii using metabolite and protein profiling. J Proteome Res. 2014; 13: 1373-1396. doi: 10.1021/pr400952z.'},{id:"B80",body:'Valledor L, Furuhashi T, Recuenco-Muñoz L, Wienkoop S, Weckwerth W. System-level network analysis of nitrogen starvation and recovery in Chlamydomonas reinhardtii reveals potential new targets for increased lipid accumulation. Biotechnol Biofuels. 2014; 7: 171. doi: 10.1186/s13068-014-0171-1.'},{id:"B81",body:'Yang ZK, Ma YH, Zheng JW, Yang WD, Liu JS, Li HY. Proteomics to reveal metabolic network shifts towards lipid accumulation following nitrogen deprivation in the diatom Phaeodactylum tricornutum. J Appl Phycol. 2014; 26: 73-82. doi: 10.1007/s10811-013-0050-3.'},{id:"B82",body:'Li Y, Han F, Xu H, Mu J, Chen D, Feng B, Zeng H. Potential lipid accumulation and growth characteristic of the green alga Chlorella with combination cultivation mode of nitrogen (N) and phosphorus (P). Bioresour Technol. 2014; 174: 24-32. doi: 10.1016/j.biortech.2014.09.142.'},{id:"B83",body:'Garnier M, Carrier G, Rogniaux H, Nicolau E, Bougaran G, Saint-Jean B, Cadoret JP. Comparative proteomics reveals proteins impacted by nitrogen deprivation in wild-type and high lipid-accumulating mutant strains of Tisochrysis lutea. J Proteomics. 2014; 105: 107-120. doi: 10.1016/j.jprot.2014.02.022.'},{id:"B84",body:'Guihéneuf F, Khan A, Tran L-S. Genetic Engineering: a promising tool to engender physiological, biochemical, and molecular stress resilience in green microalgae. Front Plant Sci. 2016; 7: 400 doi: 10.3389/fpls.2016.00400.'},{id:"B85",body:'Roesler K, Shintani D, Savage L, Boddupalli S, Ohlrogge J. Targeting of the Arabidopsis homomeric acetyl-coenzyme A carboxylase to plastids of rapeseeds. Plant Physiol. 1997; 113:75-81.'},{id:"B86",body:'Dehesh K, Tai H, Edwards P, Byrne J, Jaworski JG. Overexpression of 3-ketoacyl-acyl-carrier protein synthase IIIs in plants reduces the rate of lipid synthesis. Plant Physiol. 2001; 125:1103-14.'},{id:"B87",body:'Xue J, Wang L, Zhang L, Balamurugan S, Li D-W, Zeng H, Yang W-D, Liu J-S, Li H-Y. The pivotal role of malic enzyme in enhancing oil accumulation in green microalga Chlorella pyrenoidosa. Microb Cell Fact. 2016; 15: 120. doi: 10.1186/s12934-016-0519-2.'},{id:"B88",body:'Iskandarov U, Sitnik S, Shtaida N, Cohen SD,Stefan, Khozin-Goldberg L, Cohen Z, Boussiba S. Cloning and characterization of a GPAT-like gene from the microalga Lobosphaera incisa (Trebouxiophyceae): overexpression in Chlamydomonas reinhardtii enhances TAG production. J Appl Phycol. 2016; 28: 907-919. doi:10.1007/s10811-015-0634-1.'},{id:"B89",body:'Niu Y-F, Wang X, Hu D-X, Balamurugan S, Li D-W, Yang W-D, Liu J-S, Li H-Y. Molecular characterization of a glycerol-3-phosphate acyltransferase reveals key features essential for triacylglycerol production in Phaeodactylum tricornutum. Biotechnol Biofuels. 2016; 9: 60. doi: 10.1186/s13068-016-0478-1.'},{id:"B90",body:'Hsieh H-J, Su C-H, Chien L-J. Accumulation of Lipid Production in Chlorella minutissima by triacylglycerol biosynthesis-related genes cloned from Saccharomyces cerevisiae and Yarrowia lipolytica. J Microbiol. 2012; 50: 526-534. doi: 10.1007/s12275-012-2041-5.'},{id:"B91",body:'Yamaoka Y, Achard D, Jang S, Legéret B, Kamisuki S, Ko D, Schulz‐Raffelt M, Kim Y, Song W-Y, Nishida I, Li‐Beisson Y, Lee Y. Identification of a Chlamydomonas plastidial 2‐lysophosphatidic acid acyltransferase and its use to engineer microalgae with increased oil content. Plant Biotechnol J. 2016; 14: 2158-2167. doi: 10.1111/pbi.12572'},{id:"B92",body:'Li DW, Cen SY, Liu YH, Balamurugan S, Zheng XY, Alimujiang A, Yang WD, Liu JS, Li HY. A type 2 diacylglycerol acyltransferase accelerates the triacylglycerol biosynthesis in heterokont oleaginous microalga Nannochloropsis oceanica. J Biotechnol. 2016; 229: 65-71. doi: 10.1016/j.jbiotec.2016.05.005.'},{id:"B93",body:'Chen C-X, Sun Z, Cao H-S, Fang F-L, Ouyang L-L, Zhou Z-G. Identification and characterization of three genes encoding acyl-CoA: diacylglycerol acyltransferase (DGAT) from the microalga Myrmecia incisa. Algal Res. 2015; 12: 280-288. doi: 10.1016/j.algal.2015.09.007.'},{id:"B94",body:'Chungjatupornchai W, Watcharawipas A. Diacylglycerol acyltransferase type 2 cDNA from the oleaginous microalga Neochloris oleoabundans: cloning and functional characterization. J Appl Phycol. 2015; 27: 1499. doi:10.1007/s10811-014-0448-6'},{id:"B95",body:'Deng X-D, Gu B, Li Y-J, Hu X-W, Guo J-C, Fei X-W. The roles of acyl-CoA:diacylglycerol acyltransferase 2 genes in the biosynthesis of triacylglycerols by the green algae Chlamydomonas reinhardtii. Mol Plant. 2012; 5: 945-947. doi: 10.1631/jzus.B1300180.'},{id:"B96",body:'Murphy D. The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog Lipid Res. 2001; 40, 325-438.'},{id:"B97",body:'Farese RV Jr, Walther TC. Lipid droplets finally get a little R-E-S-P-E-C-T. Cell. 2009; 139: 855-860. doi: 10.1016/j.cell.2009.11.005.'},{id:"B98",body:'Fujimoto T, Parton RG. Not just fat: the structure and function of the lipid droplet. Cold Spring Harb Perspect Biol. 2011; 3: a004838. doi: 10.1101/cshperspect.a004838.'},{id:"B99",body:'Vieler A, Brubaker SB, Vick B, Benning C. A lipid droplet protein of Nannochloropsis with functions partially analogous to plant oleosins. Plant Physiol. 2012; 158: 1562-1569. doi: 10.1104/pp.111.193029'},{id:"B100",body:'Kimmel AR, Brasaemle DL, McAndrews-Hil M, Sztalryd C, Londos C. Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. 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Transcriptome analysis reveals unique C4-like photosynthesis and oil body formation in an arachidonic acid-rich microalga Myrmecia incisa Reisigl H4301. BMC Genomics. 12013; 4: 396. DOI: 10.1186/1471-2164-14-396.'},{id:"B105",body:'Nojima D, Yoshino T, Maeda Y, Tanaka M, Nemoto M, Tanaka T. Proteomics analysis of oil body-associated proteins in the oleaginous diatom. J Proteome Res. 2013; 12: 5293-5301.'},{id:"B106",body:'Maeda Y, Sunaga Y, Yoshino T, Tanaka T. Oleosome-associated protein of the oleaginous diatom Fistulifera solaris contains an endoplasmic reticulum-targeting signal sequence. Mar Drugs. 2014; 12: 3892-3903. doi: 10.3390/md12073892.'},{id:"B107",body:'Kim S, Kim H, Ko D, Yamaoka Y, Otsuru M,Kawai-Yamada M, Toshiki Ishikawa T, Oh H-M, Nishida I, Li-Beisson Y, Lee Y. Rapid Induction of Lipid Droplets in Chlamydomonas reinhardtii and Chlorella vulgaris by Brefeldin A. 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BMC Complement Altern Med. 2016; 16: 210. doi: 10.1186/s12906-016-1198-6.'},{id:"B115",body:'Scodelaro Bilbao PG, Damiani C, Salvador GA, Leonardi PI. Haematococcus pluvialis as a source of fatty acids and phytosterols: potential nutritional and biological implications. J Appl Phycol. 2016; 28: 3283. doi:10.1007/s10811-016-0899-z.'},{id:"B116",body:'Francavilla M, Trotta P, Luque R. Phytosterols from Dunaliella tertiolecta and Dunaliella salina: a potentially novel industrial application. Bioresour Technol. 2010; 101: 4144-4150. doi: 10.1016/j.biortech.2009.12.139.'},{id:"B117",body:'Ryckebosch E, Bruneel C, Termote-Verhalle R, Goiris K, Muylaert K, Foubert I. Nutritional evaluation of microalgae oils rich in omega-3 long chain polyunsaturated fatty acids as an alternative for fish oil. Food Chem. 2014; 160: 393-400. doi: 10.1016/j.foodchem.2014.03.087.'},{id:"B118",body:'Waghmare AG, Manoj K. Salve MK, Jean Guy LeBlanc JG, Shalini S. Arya SS Concentration and characterization of microalgae proteins from Chlorella pyrenoidosa. Biores Bioproc. 2016; 3:16. doi: 10.1186/s40643-016-0094-8.'},{id:"B119",body:'Tibbetts SM, Whitney CG, MacPherson MJ, Bhatti S, Banskota AH, Stefanova R, McGinn PJ. Biochemical characterization of microalgal biomass from freshwater species isolated in Alberta, Canada for animal feed applications. Algal Res. 2015; 11: 435-447. doi: 10.1016/j.algal.2014.11.011.'},{id:"B120",body:'Bong SC, Loh SP. A study of fatty acid composition and tocopherol content of lipid extracted from marine microalgae, Nannochloropsis oculata and Tetraselmis suecica, using solvent extraction and supercritical fluid extraction. Int Food Res J. 2013; 20: 721-729.'},{id:"B121",body:'Safafar H, van Wagenen J, Møller P, Jacobsen C. Carotenoids, phenolic compounds and tocopherols contribute to the antioxidative properties of some microalgae species grown on industrial wastewater. Mar Drugs. 2015; 13: 7339-7356. doi: 10.3390/md13127069.'},{id:"B122",body:'Shah MR, Liang Y, Cheng JJ, Daroch M. Astaxanthin-producing green microalga Haematococcus pluvialis: from single cell to high value commercial products. Front Plant Sci. 2016; 7: 531. doi: 10.3389/fpls.2016.00531.'},{id:"B123",body:'Fu W, Paglia G, Magnúsdóttir M, Steinarsdóttir EA, Gudmundsson S, Palsson BO, Andrésson OS, Brynjólfsson S. Effects of abiotic stressors on lutein production in the green microalga Dunaliella salina. Microb Cell Fact. 2014; 13: 3. doi: 10.1186/1475-2859-13-3.'},{id:"B124",body:'Borodina A, Ladygina LV. The Effect of cultivation conditions on accumulation of carotenoids in Phaeodactylum tricornutum bohl. (Bacillariophyta). Int J Algae. 2013; 15: 274-284. doi: 10.1615/InterJAlgae.v15.i3.70'},{id:"B125",body:'Borowitzka MA. Carotenoid production using microorganisms. In Cohen Z, Ratledge C (eds). Single Cells Oils: Microbial and Algal Oils. AOCS Press, Urbana. 2010; 225-240.'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Paola Scodelaro Bilbao",address:"pscodela@criba.edu.ar",affiliation:'
Laboratorio de Estudios Básicos y Biotecnológicos en Algas (LEBBA), Centro de Recursos Naturales Renovables de la Zona Semiárida (CERZOS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Camino de La Carrindanga, Bahía Blanca, Argentina
Universidad Nacional del Sur (UNS), Departamento de Biología, Bioquímica y Farmacia, San Juan, Bahía Blanca, Argentina
Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Camino de La Carrindanga, Bahía Blanca, Argentina
'},{corresp:null,contributorFullName:"Gabriela A. Salvador",address:null,affiliation:'
Universidad Nacional del Sur (UNS), Departamento de Biología, Bioquímica y Farmacia, San Juan, Bahía Blanca, Argentina
Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Camino de La Carrindanga, Bahía Blanca, Argentina
'},{corresp:null,contributorFullName:"Patricia I. Leonardi",address:null,affiliation:'
Laboratorio de Estudios Básicos y Biotecnológicos en Algas (LEBBA), Centro de Recursos Naturales Renovables de la Zona Semiárida (CERZOS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Camino de La Carrindanga, Bahía Blanca, Argentina
Universidad Nacional del Sur (UNS), Departamento de Biología, Bioquímica y Farmacia, San Juan, Bahía Blanca, Argentina
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1. Introduction
Wheat is one of the most important staple food crops supporting the world population. It ranks the second most important cereal crop of the world grown on about 220 million hectares (mha) area with 716 million tons food grain production and 3.2 tons per hectare productivity globally [1]. The current wheat production meets the demand for the existing population, but we will have to increase the production with time keeping in view to achieve the target of 858 million tons by 2050 against the current production globally [2]. Hence about 1.5% annual increase in next three decades should be kept under consideration to feed the overwhelming population. Similarly, about 37% of the wheat is cultivated as rainfed where drought is the most dominant constraint to limit wheat production [3]. Wheat is extensively grown in Asia, where Pakistan ranks eight in term of production (25 million tons) in the world [4]. The productivity of wheat is less than the 2.89 million tons per hectare for population with annual increment of 1.8% [5]. Wheat production affected by various biotic and abiotic stresses. Among the abiotic stress, water stress is affecting the vegetative growth and ultimately affecting yield of the wheat crop [6] (Figure 1).
Figure 1.
Schematic representation of the drought effect on physiological processes, growth and yield.
Drought stress is the most prominent factor in crop production that affects the yield stability in the world [6]. Likewise, in rainfed areas the erratic rainfall is also the prime factor that limits crop productivity in in semiarid areas [7]. The occurrence of insufficient rainfall which does not meet the water requirement of the crop life cycle in certain areas occasionally cause the total crop failure [8]. The use of ground water is practice for crop production, and this ground water is declining with time with significant adverse effect on the water table due to the non-judicious use of the ground water resources [9]. Therefore, certain water conservation measures and water saving strategies and techniques should be adopted to cope with this adverse condition thereby conserving the precipitation water in the rhizosphere for the optimum crop production [10, 11].
As an essential macronutrient of plants, N is necessary for the vegetative growth, biomass, protein synthesis and the photosynthetic machinery of the crops [12]. This N is available in various forms in the rhizosphere, i.e. organic, such as in the form of amino acid and proteins, and inorganic forms, urea, nitrate ions (NO3−), ammonium ions (NH4+) and is also found in the form of other nitrogenous compounds [13]. Of them, only NO3- and NH4+ are the forms of soil N that are easily taken by the plants through roots from the rhizosphere [14]. The aforesaid two forms need enough soil moisture for efficient absorption through the plant roots because of their high mobility in water [15]. The soil water is extracted by the plants through its roots and thereby using it for various physiological processes, maintaining internal temperature and for the process of transpiration [16]. Plant uptake various nutrients from soil solution including N for the optimum growth and development. In drought prone areas or areas where there is less and/or no eater availability because of the shortage of water or undependable nature of the rainfall, plants are with lower N uptake and hence the overall physiological process and activity of N assimilation enzyme is also retarded [17, 18]. Therefore, the plants ability to uptake N from the soil is not only the function of N concentration and availability in soil but also the soil moisture in the root zone [19].
Soil water and Nitrogen (N) are considered as the key limiting factors for maximizing plant growth, yield and quality [20]. The effect of these limiting factors is most prominent in the growing area where water stress is prevalent [21]. All the metabolic processes, biomass assimilation, growth functions and nutrients allocation in the plants are controlled by the interaction of N and water [22]. It is therefore kept in mind that wheat yield might be increased when crop ins not restricted with both N and water supply. For the availability of N optimum moisture in soil is needed. Contrary to this, enough amount of N needs to be in soil to make use of water available. In most areas, wheat yield is affected by the drought induced N deficit. Wheat morphology, physiology and biochemical character is also affected by water stress and nitrogen dynamics in the rhizosphere.
2. Morphophysiological, biochemicals and yield of wheat under water and N-colimitation
Water and N availability, the most limiting crop growth factors affecting adversely the morphological traits, physiology of the crop, alter the biochemical changes in the grains and shoots and final yield of the crop [23]. The resource use efficiency of N and water for the crop is the need of the day. Water stress adversely affects the vegetative growth, physiological processes, biochemical properties of the grains and shoots [24] (Figure 2). The amount of N applied to the crop is determined by the soil moisture status, amount and frequency and frequency of precipitation during the crop growth season [25]. The higher photosynthesis, water use efficiency (NUE) and water uptake could be achieved with optimum N supply under optimum water supply [26]. Leaf anatomy, leaf rolling, leaf hairs, stomatal positions and opening/closing, are the traits of wheat crop to withstand with under various environmental stresses especially water deficit [27]. Likewise, the photosynthesis rate, transpiration, osmotic potential, relative water contents, stomatal conductance are also affected by water and N depletion [28]. Rubisco efficiency, photochemical efficiency, reactive oxygen species, antioxidants defense system, abscisic acid generation, proline accumulation, polyamines generation, increase in antioxidative enzymes, carbohydrate and protein dynamics, amylose and amylopectin contents are affected by under water and N colimitation [29].
Figure 2.
Morphological, physiological and biochemical dynamics of plants affected by water stress.
2.1 Morphological traits of wheat under water and N colimitation
The strong association of WUE and NUE are observed commonly in different agriculture systems including crop husbandry [29]. Certain management practices which are in the way to enhance N and/or WUE at the same time are considered beneficial in term of production cost for the crops especially cereals thereby economizing water and N inputs separately [30]. The morphological attributes of the wheat crop especially the leaf traits i.e. leaf shape, size, expansion, leaf area, senescence, waxiness, leaf hairs and pubescence and the cuticle tolerance of the wheat is affected under water limited conditions [31, 32]. Similarly, the root characteristics i.e. dry weight, density and root length are adversely affected by soil moisture limitation in the rhizosphere [33]. Despite this, the vegetative and reproductive stages of the wheat crop are also affected by water deficit and limited N supply [34]. The better strategies adopted by the plants by modifying its life cycles to theses abiotic stresses (i.e. water and N deficit) are early maturation, small plant size and reduced leaf area for the drought tolerance [35]. It is observed that under water limitation, the flag leaf length is increased, and no significant change was observed in leaf width [36]. Hence, leaf expansion is the function of water extracted from the rhizosphere through rood and its abundance in plant tissues [37]. A decrease in leaf number, size and longevity may be observed under water and N limitation subsequently and their non availability alone as well [37]. In wheat crop, the leaf development is significantly affected by soil moisture depletion thereby decreasing overall biomass [38]. Similarly, N is considered as the integral part of the plant and plays a key role in increasing the leaf area, plant height and finally biomass of the plant under optimum supply [39]. Therefore, both water and N are equally important, their distribution and prevalence should keep in mind as there is a strong linkage between water and N limited supply [40]. Better morphological attributes with less production cost could be achieved under N and water colimitation.
2.2 Physiological response of wheat under water and N colimitation
In regulating plant growth, N plays vital role with a prominent impact on the crop physiology under drought induced N deficit [41]. The biomass of the wheat crop is not only affected under low N availability, but does significantly increased under optimum water supply, mainly because of the higher N content in the rhizosphere which clarifies that with the optimum N supply the presence of adequate availability of soil moisture is therefore essential for biomass, yield and physiological attributes of the wheat crop [42]. The N deficiency the sensitivity of the stomata under water deficit condition in drought prone areas [43]. The leaf photosynthesis rate is significantly affected by the optimum supply of both N and water to the crop [44]. Increase in the photosynthetic activity and biomass accumulation is observed under optimum water and limited N supply [45]. Water use efficiency (WUE) is enhanced through photosynthesis, stomatal conductance and mesophyll conductance in wheat crop and thus ultimately increasing N uptake and nitrogen use efficiency (NUE) [46]. Non availability of soil moisture will not only affect N supply but also have bad effect on N cycling [47]. Thus, water plays vital role in the availability of N in the soil solution to crop and thereby enhancing the photosynthesis process, translocation of assimilates, metabolism and conversion efficiency of the crop [48].
2.3 Biochemical traits of wheat crop under water stress and N limitation
Certain different compounds and metabolites that are accumulated in the crop under water deficit conditions to cope with the drought stress imposition [49]. These metabolites are of key importance because of their peculiar biochemical routes and thereby enhancing the tolerance mechanism in crop plants [50]. A cross talk between various biochemical substances and metabolites are initiated through drought signaling [51]. Various substances are accumulated in the plants body under abiotic stresses especially water stress. Under water limited conditions, proline a key metabolite, that is accumulated in higher concentration under dehydration [52]. The antioxidation enzymes that scavenge the ROS (reactive oxygen species) through various osmo-protection processes that includes stability of the membrane, osmotic adjustment and gene signaling are strongly associated [52]. The vital role in drought tolerance and strong defensive antioxidant mechanism in wheat genotypes are strongly correlated with high proline concentration [53]. The genotypes grown in rainfed areas having high proline concentration compared with the ones grown in irrigated and/or humid areas [54]. Various internal physiological processes are taking place under the crop plants to cope with the drought stress [55]. Plant growth is inhibited, water loss and stomatal closure are regulated, guard cell ion translocation is alternated under water stress through the translocation of ABA from roots to leaves [56]. The wheat crop having less ABA accumulation in leaves are considered to be susceptible to drought stress compared to those which accumulate high proline contents in leaves are drought tolerant [57]. Similarly, the wheat genotypes with high proline concentration in the leaves exhibited better water use efficiency [58]. In wheat crop auxin is considered as negative regulator for drought stress. Similarly, the indole acetic acid (IAA) contents also decreasing under water limitation [59]. The antioxidant enzymes (POD), H2O2, glutathionse (GSH), proline, and malondialdehyde (MDA) concentrations are measured maximum in the wheat plants subjected to water stress [60].
2.4 Yield and yield contributing traits
Most of the yield traits that are associated with the improved productivity in water limited areas are complex and polygenic in nature [61]. Drought stress significantly affected the yield and yield attributes of wheat compared with well water conditions [62]. Thousand kernel weight decreased by 16% under water limited condition thereby affecting overall grain production of wheat crop under drought prone environments [63]. Similarly, the most important yield contributing trait i.e. grain number were also affected by the water stress with less grain number in the crop under drought stress imposition [64]. All the yield components are affected by the drought stress, but the effect was more prominent on grain weight and grain number that contribute to the economic yield of the crop [65]. Water stress causes reduction in grain number to a greater degree that size of the grain, hence grain number exhibiting more plasticity that rest of the components [66]. The narrow variability and low plasticity of the grain size under water stress environments resulting in efficient transport of the pre anthesis assimilates to sink [67]. The reproduction process in the plants is severely affected by water stress, cereal crops exhibits a strong adaptive mechanism up to some extent through the accumulation of the photosynthates in various parts i.e. stem and roots in early growth phase and having the ability to reallocate the assimilates to the sink in reproductive phase of development [68]. The efficient use of the resources like limited water and N rates are the better strategy for wheat production [69]. For primary productivity photosynthetic capacity of the crop plants is the key to higher yield [70]. Water use efficiency provides a simplest mean of assessing whether yield is limited by water supply or other factors and is considered an important component of adaptation to water deficit conditions [71]. As the amount of water used is strongly affected by crop management, a good understanding of crop management effects on WUE may provide researchers opportunities to identify and select appropriate crop management practices for improved water use efficiency [72]. Limited supplemental irrigation and fertilization during the growth season can significantly increase WUE and wheat yield [73].
3. Pathways to improve water and N use efficiency
3.1 Approaches for enhancing water use efficiency (WUE)
Certain agronomic, soil management strategies that may improve the WUE are discussed as under.
3.1.1 Agronomic perspectives
The water use efficiency is the function of the agronomic practices that includes tillage practices, drought resistant and adaptive cultivars, soil fertility and pest management [74]. The crop growth and yield tends to increase under no till system or incorporation of the crop residues which directly influences the availability of soil moisture [75]. Similarly, WUE of the wheat crop enhanced under optimum sowing window, row spacing and seed rate which ultimately increments in wheat production [76]. Decreasing row spacing and increasing seed rate could enhance water soil moisture and thereby increasing water use efficiency [77]. Under optimum row spacing weeds growth is discouraged and hence crop may uptake nutrients and water efficiently [78]. Adjustment in the crop growth season through alteration of the sowing dates keeping in view the seasonal transpiration demand [79]. Early sown crop under conservation agriculture could also increase WUE of grain crops. Drought resistant cultivars resulting in high WUE than the cultivars which are drought susceptible [80]. A well-prepared sowing beds and leveled fields are the prerequisites for water saving and greater yield harvesting. The laser leveling is considered as the effective method responsible for various benefits i.e. germination uniformity, irrigation time reduction, decrease in pest and decreasing production cost [80]. The exogeneous application of certain compounds like silicon, selenium, potassium, hydrogel etc. increase the water use efficiency of the wheat crop under stressful environments, decreasing the adverse effects of biotic and abiotic stresses, enhance bioavailability of nutrients, photosynthetic efficiency and better light harvesting [81].
3.1.2 Soil management perspective
The crop yield and WUE could be significantly increased under better soil management practices through increasing water holding capacity (WHC), ease in soil moisture extraction and by decreasing the water losses through leaching [82]. Increment in WUE could be observed under good soil management practices, that causes soil moisture dynamics by evaporation and infiltration to soil that tends to increase soil water retention capacity and organic matter contents [83]. It is observed over various types and classes of soils, increment in water content at field capacity (FC) is greater than that at permanent wilting point (PWP) when soil organic matter contents are increased [84]. There is also a chance to conserve soil moisture through albedo under high plant density and narrow row spacing [85]. Compared to no tillage, disturbance taken place through tillage practices are more prominent in moisture loss through evaporation. The soil evaporation could be reduced up to 50% by crop residue incorporation [86]. This shows the gaps related to soil management that are responsible and having potential to improve WUE.
3.1.3 Physiological and anatomical perspective
3.1.3.1 Stomatal physiology and biochemistry dynamics
High stomatal conductance in needs more water to fix per unit leaf area for increasing the soil and water use during transpiration [87]. For increasing WUE, during peak hours of the day when transpiration is high by preventing the loss of water from the leaves through prevention by sensitivity of the stomata. Through the process of transpiration water is lost in the form vapor which facilitates CO2 uptake [88]. Thus stomata plays a vital role in increasing WUE, thereby controlling the water loss in the form of vapor and CO2 gain [89]. The opening and closing of stomata is also regulated by the environment determinants [90]. Stomatal moment is controlled by the transport and osmotically active solute accumulation and the guard cells lateral moments [91]. In most of the plant leaves, stomata are separated through an epidermal cell creating space for opening and closing [92]. In certain plant species, the clustering of stomata is also considered a better strategy for lowering evaporation demand and this phenomenon in the crop plants is considered better adaptation in drought prone areas [93].
3.1.3.2 Crop environment, root architecture and harvest index enhancement
Growing of the crops in environments where there is less transpiration will result in higher WUE. The identification and allocation of such areas having less transpiration could be identified through spatial and temporal scale [94]. Enhancement in harvest index increases the water use efficiency, this provides a new research window for increasing WUE in drought prone environments [95]. The harvest index is decreased by the water stress imposition at reproductive stage of the wheat crop, hence certain strategies need to be defined to conserve the soil moisture for the future use in reproductive stage of plant growth and development [96]. Similarly, root canopy and architecture are playing important role in extracting soil moisture [96]. Rood density, root angle, root hairs, root type and root length are the characteristics that determines the water uptake from various depths of the rhizosphere [97]. In wheat crop stele and xylem number are considered to be more responsive in wheat crop in water stress conditions because of the more xylem developmental plasticity in wheat crop [98]. In cereal crops, the metaxylem diameter and density are responsible for high WUE [99].
3.2 Approaches for enhancing nitrogen use efficiency (NUE)
The grain production per unit of soil available N is termed as nitrogen use efficiency. Certain approaches that should be kept in mind while enhancing the NUE of grain crop are described as under.
3.2.1 Agronomic perspective
Nitrogen is accepted universally as an essential component of crop production. The climatic condition is different for every crop. There are some of the main factors i.e. rainfall, solar radiation and temperature that significantly influence the demand for nitrogen, influence nitrogen use efficiency (NUE) and crop growth [100]. The demand of N to plant increases as plant grows showing a sigmoid curve (Figure 3). It has generally observed that nitrogen element significantly enhanced the biomass of the plant/crop if it absorbed by plant properly because maximum biomass and plant growth totally determined by the uptake and loss of nitrogen [101]. Yet, due to leaching and volatilization of nitrogen the crop cannot uptake nitrogen easily from the soil because the due to leaching the nitrogen moves down from the below root zone. Thus, efficient nitrogen management could significantly improve the nitrogen use efficiency [102].
Figure 3.
Graphical representation of N needed for plant growth/N uptake pattern during life cycle the plant.
Water availability is the essential factor that affected the NUE under limited water availability which is crucial from an environmental and economic standpoint [103]. Maximum nitrogen use efficiency (NUE) in drought tolerant varieties of winter wheat as compared with drought sensitive lines of winter wheat. Drought resistant varieties of wheat crop consistently produced higher yield as compare with drought sensitive varieties [104]. Higher nitrogen use efficiency (NUE) and water use efficiency (WUE) in drought resistant wheat varieties. Nitrogen rate parabolically increased with rainfall, while WUE and NUE were linearly related [105]. Simultaneous enhancement of NUE and WUE were more beneficial than optimization of nitrogen and water individually. It is also stated that low nitrogen application could enhanced the nitrogen use efficiency when supplied it from organic sources rather than commercial. Excess application of nitrogen to the crop could significantly reduce the crop yield and drastically decreased the nitrogen use efficiency. It is therefore, important to obtain the higher nitrogen use efficiency through adaptation of nitrogen management strategies and agronomic practices under deficit irrigation or water stress condition.
3.2.2 Rotation of crops
It is an effective strategy to enhance the nitrogen use efficiency. Effective use of soil resources i.e. nutrient and water and appropriate crop sequences could maximize the crop yield. Increase in crop yield is associated with crop rotation is known as rotation effect while monoculture practice significantly decreased the crop yield [106]. There is an effective management practice of legumes and non-leguminous crop which linearly enhanced the crop yield and other yield components. Monoculture practice in field significantly declined the cop yield and degrade the soil fertility, while crop rotation is an effective strategy to obtain the higher crop yield [107]. Leguminous crops should be included to enhance the crop yield and also suppress the weeds and decreased the risk of disease infestation. There are the following benefits of crop rotation which enhanced the nutrient use efficiency, water use efficiency, reduced allelopathy and improved soil quality [108]. Cereals are the largest consumers of nitrogen use efficiency as compared with leguminous crop. Crop rotation could reduce the immobilization and residual soil nitrate available for leaching. Leguminous crops increased the soil fertility, enhanced the soil microbial activity and improve the soil structure. Leguminous crop also add nitrogen to the soil from the atmosphere due to presence of nodules in the roots [109]. Rotation practices also enhance the nitrogen use efficiency (NUE). As compare to cereals crop, leguminous crops enhanced the soil fertility, improve soil texture and structure and enhance microbial activity. Rotation practice enhance the nitrogen use efficiency (NUE), However, they also stated from their study that nitrogen supplied to the crop following a legume have been inconsistent [110]. Several studies have been documented that NUE could enhance the crop yield when supplied it from organic sources as compared with inorganic sources. Crop rotation practice significantly increased the nitrogen use efficiency (NUE) and other components.
3.2.3 Irrigation management
Irrigation management is an appropriate strategy to improve the water use efficiency and fertilizer use efficiency. Border and furrow irrigation are traditional method used for vegetable and field crops [111]. These two practices are generally associated with higher percolation losses which resulted in low nitrogen use efficiency (NUE) and water use efficiency (WUE). These traditional methods are increasingly becoming difficult in the changing climate scenario. Adoption of water efficient irrigation and other modern irrigation techniques are the best strategies to obtain the higher NUE and WUE. Many researchers confirmed that deficit irrigation strategy enhance the WUE and NUE (water use and nitrogen use efficiency) [112]. According the several authors, maximum recovery efficiency, of nitrogen applied is due to high irrigation of overhead sprinklers. Strategy of water management is linked with the nitrogen nutrition and significantly affects the NUE and WUE [113]. Water application and their adjustment is to match the actual crop demand which is an effective management technique for obtaining higher NUE and WUE.
3.2.4 Nitrogen source and placement method
The uptake efficiency of most of the crops is dependent on the N source and application method. Nitrogen is lost (Figure 4) through urease hydrolysis to atmosphere when applied to the soil surface from urea based N source, this is because of the increased soil pH resulting its volatilization [114]. Farmers are increasing the application rate to their field for optimum productivity but in vain because this have a deleterious effect on soil, atmosphere and aquatic bodies as well [115]. Certain slow N release fertilizers are manufactured with the aim to reduce the losses [116]. The NUE could be maximized and losses are reduced under proper N application strategies [117]. Side dressing or band application, mixing in soil, injecting to soil sub surface of N fertilizers are the different strategies that could enhance the N efficiency than the broadcast application. Surface broadcast N application resulting in greater loss as ammonia-N to atmosphere, this could be minimized if banded, side dressed, placed with or below seed, or injected to soil [118].
Figure 4.
Schematic diagram showing various processes of N cycle in soil plant atmosphere system.
3.2.5 Physiological perspective
The vital factor which is responsible for growth and development of the crop is nitrogen, increases various traits of the crop thereby improving final yield [119]. The N availability affects the carbon and N partitioning between roots and shoots of the crop [120]. Under high N availability, the root shoot ratio decreases because of the prominent growth of shoots [121], this varies among varieties and cultivars. The timing of N availability is of utmost importance in wheat crop where it affects all the yield parameters especially tiller density, spike compactness, grain number, kernel weight and grain N ad protein concentration [122]. Wheat crop store and sequester the N in vegetative stage, this stored N is re allocated to the grains during reproductive stage, of them some become the part of cell wall. In grain crops, about 50–70% of the N is translocated and accumulated at maturity [123]. The N harvest index could be improved by the sequestration of N in shoots and grains. Alteration in leaf area index and specific leaf N can enhance the NUE. Understanding these physiological characteristics that regulate plant N uptake, grain N uptake, root N uptake, assimilatory process, redistribution of N within the cell, and leaf structure and architecture can help improve NUE physiologically [124]. N uptake and LAI were found directly proportional for NUE and wheat productivity [125]. Under N- and water-limited conditions the overexpressing a downstream N assimilation gene called alanine amino transferase has increased N uptake and use efficiency [126]. Another way of increasing N uptake in plants is enhancing larger and deeper roots that can capture more available N in the soil profile. Vigorous root and shoot growth are necessary for higher N recovery [127].
4. The intricate relationship between nitrogen and water colimitation
Various literatures are present and research work has been done on the nitrogen and water stress individually but there is need to explore the intricate effect of both N and/or water (Figure 5) thereby decreasing cost of production of wheat crop and to enhance the grain and biomass yield [128]. Both the water and N rates need to be economized for optimum wheat production under high WUE and NUE simultaneously [129]. The effect of N and water on the process of photosynthesis is present in literature, claims the positive effect of N rate on photosynthesis. Similarly, with increase in soil moisture the physiological processes are positively influenced and results in optimum wheat production [130]. In fact, there are diminishing return that with the increase of N and water, the photosynthesis rate increases, but the rate of photosynthesis tends to saturate with further increment of water and N resulting in less WUE and NUE for the wheat crop and increasing cost of production [131]. Under certain environments, it is reported that NUE may increase under maximum supply of water and contrary to this N increment may also increase WUE [132]. Therefore, the interaction of N and water is the interplay of management, environment and cultivar collectively [133]. Application of irrigation water at higher rate may cause N losses through leaching resulting in N shortage in the rhizosphere [134], this condition also leads to stomatal closure thereby affecting the crop physiological processes. Under low N availability, photosynthesis process will be less leading to reduction in wheat productivity with less WUE [135]. On the other hand, the crop susceptibility to drought, temperature stress and may increase under high N application. Plant species differs in demand for N and water that affects the photosynthesis process. The studies also suggest that increasing both N and water has positive effect on yield rather than increment in either factor. This increment in both N and water leads to higher production cost, water loss, affecting water quality, aquatic flora and fauna and ultimately causes pollution of water and air as well [136]. It is thought that N input effect will be more efficient at low water input that the higher water supply. Similarly, the NUE decreases with higher N rate and increment in water input may increase NUE at lower N rate.
Figure 5.
The intricate relationship of water and N for optimum N uptake affecting plant physiological processes.
5. Nitrogen (N)-climate interaction; fix N to fix climate change
The wide spread use of synthetic fertilizers in agriculture [137, 138], fossil fuel use from the industry, leguminous crops cultivation on large scale has therefore increased the reactive nitrogen in the atmosphere in the last five decades [139, 140, 141]. Globally, a great threat is there to impair the water and air quality [142], biodiversity and human health due to unpredictable alteration in biogeochemical cycle especially N [143]. The considerable amount of N is lost through leaching in the form of NO3-N [144, 145]. This NO3-N leaching varies due to the N status of the soil and greatly depends on soil properties [146, 147, 148, 149]. Thus, the shallow ground water and aquifers are contaminated through the soluble nature of the NO3 in soil water [150, 151]. Worldwide, NO3-N is considered as the major concern as it deteriorates the ground water and surface water quality since few decades [152, 153, 154]. Increment in the NO3-N contents in drinking water have bad effect on human and animals health as well [155, 156], also the aquatic bodies are contaminated through its higher concentration accumulation [157, 158, 159, 160] thereby favoring the aquatic plants to grow and nourish well [161, 162] by making a surface layer thereby impeding the solar radiation to reach the aquatic fauna [163, 164, 165, 166] and ultimately causing the death of the aquatic fauna [167] which creates eutrophication [168]. Besides this, blue baby syndrome in infants (methemoglobinemia) and human birth defects [169] are the major serious problems linked with NO3 contamination [170, 171]. Therefore, it is of prime importance to estimate the NO3 leaching from cropland [172] and to evaluate the environmentally compatible and economically suitable agronomic practices [173] that could maintain and/or decrease this phenomenon [174].
The increment in the NO3 leaching loss is strongly correlated with the rainfall occurrence, intensity and irrigation volume and methods [175]. The excessive fertilization increases the risk of N loss through leaching in agriculture system [176, 177]. To feed the overwhelming population of the world, higher fertilizer application to crop field [178] is under practice have rapidly raised the NO2 emission of the atmosphere [179, 180] and is expected to increase linearly in coming decades [188], aggravating the environmental quality [181]. Through the anthropogenic rise in NO2 emission from agriculture sector to atmosphere thereby offset the efforts to decrease the CO2 sully from other sectors [182].
Global warming is directly affected by NO2 emission [183] which is considered as a major greenhouse gas [192], having 300 times more potent than CO2 because of its greater resident time in the atmosphere usually greater than 100 years [184]. The unregulated and increasing trend of the NO2 defines the global warming [185]. This increment in N availability in atmosphere affects the sinks and sources of NO2, CH4 and CO2 thereby potential increase in CO2 sequestration [186].
Climate change will certainly increase the N emission, which in turn will affect the agriculture system, aquatic water bodies, humans and animals’ health [187]. Thus, climate N cross talk will expose the crops to elevated O3 [188]. Greater emission of the N will be observed from livestock and agriculture production systems as well [189]. Drought spell, erratic and unpredictable rainfall, temperature events taken place because of climate change will ultimately affects the farmers decisions and practices thereby enhancing C and N release from agriculture ecosystem [190] when higher N rates are practiced keeping in mind leaching losses [191]. N availability to crops impedes and its losses will increase under drought induction, irregularity in rainfall, high temperature events and flooding [192].
Nitrogen, the essential macronutrient responsible for plant growth and development is fundamental for farming [191]. Climate change impact may be taken under consideration for minimizing N losses [193, 194] and to manage N in better way [195, 196, 197]. Perturbation to both N and climate needs to be fixed to reduce its adverse effects environmentally compatible and economically suitable agronomic practices [198]. Firstly, irrigation water availability to field crops is a great question and this the situation become worsen in each passing day. Then the application volume to field crops in higher rates decreasing the WUE on one way and depleting the available nutrients in the soil on other hand because farmers are applying higher fertilizers to harvest maximum yield thereby ultimately increasing their cost of production. Therefore, a gate way for future research is to economize the N rates/levels for the crop growth, yield and quality by monitoring the rhizosphere moisture for irrigation water optimization till moisture allowable depletion (MAD) of the respective crops that may not affect its growth and development but also enhance the availability and utilization of the nutrients in soil solution.
6. Conclusion
This chapter provides the information regarding water and N rates on wheat physiological, morphological, biochemical, qualitative changes and yield traits of wheat crop focusing on the NUE and WUE. Drought stress is the most prominent limiting factor that manipulates the physiological pathway, biochemical traits and hence negatively affects wheat crop productivity. The global nitrogen (N) recovery indicated that about two-fifths of N inputs are lost in the ecosystems through leaching, gaseous emission, denitrification, surface runoff and volatilization. About 50–60% of the applied N fertilizer to the field are lost to environment and thus not available to the plants. These deleterious environmental consequences need to be reduced by efficient management of N and/or water focusing on their intricate relationship. N-availability is often regulated by soil water; hence crop is experiencing N- and water-limitation simultaneously. There is great impetus to optimize their uptake through interconnectedness of water and N for yield determination of wheat because of the water scarcity and N losses for enhancing wheat productivity and thereby reducing the production cost. There is need to optimize the N and water colimitation simultaneously to determine the minimum N and water to harvest optimum yield with better baking quality and hence safeguarding the environment, soil micro fauna and water bodies.
Therefore, a gate way for future research is to economize the N rates/levels for the crop growth, yield and quality by monitoring the rhizosphere moisture for irrigation water optimization till moisture allowable depletion (MAD) of the respective crops that may not affect its growth and development but also enhance the availability and utilization of the nutrients in soil solution.
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"drought, water-N co-limitation, physio biochemical traits of wheat, N losses, NUE and WUE",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/73771.pdf",chapterXML:"https://mts.intechopen.com/source/xml/73771.xml",downloadPdfUrl:"/chapter/pdf-download/73771",previewPdfUrl:"/chapter/pdf-preview/73771",totalDownloads:456,totalViews:0,totalCrossrefCites:0,dateSubmitted:"May 26th 2020",dateReviewed:"October 6th 2020",datePrePublished:"October 28th 2020",datePublished:"July 21st 2021",dateFinished:"October 28th 2020",readingETA:"0",abstract:"Drought stress is the most prominent limiting factor and abiotic stress that manipulates the physiological pathway, biochemical traits and hence negatively affects wheat crop productivity. The global nitrogen (N) recovery indicated that about two-fifths of N inputs are lost in the ecosystems through emission, denitrification, gaseous loss, leaching, surface runoff and volatilization etc. Farmers are using higher rates of N to harvest maximum yield but about 50–60% of applied N to crop field is not utilized by the plants and are lost to environment causing environmental pollution. These deleterious environmental consequences need to be reduced by efficient management of N and/or water. N-availability is often regulated by soil water; hence crop is experiencing N- and water-limitation simultaneously. There is great impetus to optimize their uptake through interconnectedness of water and N for yield determination of wheat because of the water scarcity and N losses. It is further advocate that there is need to investigate the intricate role of economizing N rate and water simultaneously for wheat crop growth, yield and backing quality may be beneficial to be investigate.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/73771",risUrl:"/chapter/ris/73771",signatures:"Nawab Ali and Mohammad Akmal",book:{id:"10363",type:"book",title:"Abiotic Stress in Plants",subtitle:null,fullTitle:"Abiotic Stress in Plants",slug:"abiotic-stress-in-plants",publishedDate:"July 21st 2021",bookSignature:"Shah Fahad, Shah Saud, Yajun Chen, Chao Wu and Depeng Wang",coverURL:"https://cdn.intechopen.com/books/images_new/10363.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83881-062-7",printIsbn:"978-1-83881-055-9",pdfIsbn:"978-1-83881-063-4",isAvailableForWebshopOrdering:!0,editors:[{id:"194771",title:"Dr.",name:"Shah",middleName:null,surname:"Fahad",slug:"shah-fahad",fullName:"Shah Fahad"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"240710",title:"Dr.",name:"Nawab",middleName:null,surname:"Ali",fullName:"Nawab Ali",slug:"nawab-ali",email:"nawab@aup.edu.pk",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Abdul Wali Khan University Mardan",institutionURL:null,country:{name:"Pakistan"}}},{id:"333984",title:"Prof.",name:"Mohammad",middleName:null,surname:"Akmal",fullName:"Mohammad Akmal",slug:"mohammad-akmal",email:"akmal_m@hotmail.com",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333984/images/14708_n.jpeg",institution:null}],sections:[{id:"sec_1",title:"1. 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Pathways to improve water and N use efficiency",level:"1"},{id:"sec_7_2",title:"3.1 Approaches for enhancing water use efficiency (WUE)",level:"2"},{id:"sec_7_3",title:"3.1.1 Agronomic perspectives",level:"3"},{id:"sec_8_3",title:"3.1.2 Soil management perspective",level:"3"},{id:"sec_9_3",title:"3.1.3 Physiological and anatomical perspective",level:"3"},{id:"sec_9_4",title:"3.1.3.1 Stomatal physiology and biochemistry dynamics",level:"4"},{id:"sec_10_4",title:"3.1.3.2 Crop environment, root architecture and harvest index enhancement",level:"4"},{id:"sec_13_2",title:"3.2 Approaches for enhancing nitrogen use efficiency (NUE)",level:"2"},{id:"sec_13_3",title:"3.2.1 Agronomic perspective",level:"3"},{id:"sec_14_3",title:"3.2.2 Rotation of crops",level:"3"},{id:"sec_15_3",title:"3.2.3 Irrigation management",level:"3"},{id:"sec_16_3",title:"3.2.4 Nitrogen source and placement method",level:"3"},{id:"sec_17_3",title:"3.2.5 Physiological perspective",level:"3"},{id:"sec_20",title:"4. The intricate relationship between nitrogen and water colimitation",level:"1"},{id:"sec_21",title:"5. Nitrogen (N)-climate interaction; fix N to fix climate change",level:"1"},{id:"sec_22",title:"6. Conclusion",level:"1"},{id:"sec_26",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Cakmak I, Kutman UÁ. Agronomic biofortification of cereals with zinc: a review. European Journal of Soil Science. 2018 Jan;69(1): 172-80.'},{id:"B2",body:'Fischer G. World food and agriculture to 2030/50. Tech. Pap. from Expert Meet. How to Feed World. 2009 Jun 24:24-6.'},{id:"B3",body:'Sedri MH, Amini A, Golchin A. Evaluation of nitrogen effects on yield and drought tolerance of rainfed wheat using drought stress indices. Journal of Crop Science and Biotechnology. 2019 Sep 1;22(3):235-42.'},{id:"B4",body:'Younis H, Abbas G, Naz S, Fatima Z, Ali MA, Ahmed M, Khan MA, Ahmad S. Advanced production technologies of wheat. InAgronomic Crops 2019 (pp. 223-236). Springer, Singapore.'},{id:"B5",body:'Shiferaw B, Smale M, Braun HJ, Duveiller E, Reynolds M, Muricho G. Crops that feed the world 10. Past successes and future challenges to the role played by wheat in global food security. Food Security. 2013 Jun 1;5(3):291-317.'},{id:"B6",body:'Fahad S, Bajwa AA, Nazir U, Anjum SA, Farooq A, Zohaib A, Sadia S, Nasim W, Adkins S, Saud S, Ihsan MZ. Crop production under drought and heat stress: plant responses and management options. Frontiers in plant science. 2017 Jun 29;8:1147.'},{id:"B7",body:'Singh HP. Unit-1 Definition and Concept of Rain Fed Farming. IGNOU.'},{id:"B8",body:'Van Loon AF. Hydrological drought explained. Wiley Interdisciplinary Reviews: Water. 2015 Jul;2(4):359-92.'},{id:"B9",body:'Sahrawat KL, Wani SP, Pathak P, Rego TJ. Managing natural resources of watersheds in the semi-arid tropics for improved soil and water quality: A review. Agricultural Water Management. 2010 Mar 1;97(3):375-81.'},{id:"B10",body:'Ullah H, Santiago-Arenas R, Ferdous Z, Attia A, Datta A. Improving water use efficiency, nitrogen use efficiency, and radiation use efficiency in field crops under drought stress: A review. InAdvances in Agronomy 2019 Jan 1 (Vol. 156, pp. 109-157). Academic Press.'},{id:"B11",body:'Kumar A, Nayak AK, Das BS, Panigrahi N, Dasgupta P, Mohanty S, Kumar U, Panneerselvam P, Pathak H. Effects of water deficit stress on agronomic and physiological responses of rice and greenhouse gas emission from rice soil under elevated atmospheric CO2. Science of the Total Environment. 2019 Feb 10;650:2032-50.'},{id:"B12",body:'Nowicka B, Ciura J, Szymańska R, Kruk J. Improving photosynthesis, plant productivity and abiotic stress tolerance–current trends and future perspectives. Journal of plant physiology. 2018 Dec 1;231:415-33.'},{id:"B13",body:'Manikandan A, Subramanian KS. Ability of Urea Impregnated Biochar Fertilizers For Securing the Slow Release of Nitrogen in Soils–Preliminary Study. International Journal of Agriculture Sciences, ISSN. 2015:0975-3710.'},{id:"B14",body:'Hill PW, Jones DL. Plant-microbe competition: does injection of isotopes of C and N into the rhizosphere effectively characterise plant use of soil N. New Phytol. 2019 Jan 1;221:796-806.'},{id:"B15",body:'Tardieu F, Simonneau T, Muller B. The physiological basis of drought tolerance in crop plants: a scenario-dependent probabilistic approach. Annual review of plant biology. 2018 Apr 29;69:733-59.'},{id:"B16",body:'Kathpalia R, Bhatla SC. Plant Mineral Nutrition. InPlant Physiology, Development and Metabolism 2018 (pp. 37-81). Springer, Singapore.'},{id:"B17",body:'Kitonyo OM, Sadras VO, Zhou Y, Denton MD. Nitrogen supply and sink demand modulate the patterns of leaf senescence in maize. Field Crops Research. 2018 Aug 1;225:92-103.'},{id:"B18",body:'Antoniadis V, Levizou E, Shaheen SM, Ok YS, Sebastian A, Baum C, Prasad MN, Wenzel WW, Rinklebe J. Trace elements in the soil-plant interface: Phytoavailability, translocation, and phytoremediation–A review. Earth-Science Reviews. 2017 Aug 1;171:621-45.'},{id:"B19",body:'Leghari SJ, Wahocho NA, Laghari GM, HafeezLaghari A, MustafaBhabhan G, HussainTalpur K, Bhutto TA, Wahocho SA, Lashari AA. Role of nitrogen for plant growth and development: A review. Advances in Environmental Biology. 2016 Sep 1;10(9):209-19.'},{id:"B20",body:'Jaleel CA, Manivannan PA, Wahid A, Farooq M, Al-Juburi HJ, Somasundaram RA, Panneerselvam R. Drought stress in plants: a review on morphological characteristics and pigments composition. Int. J. Agric. Biol. 2009 Jan 1;11(1):100-5.'},{id:"B21",body:'Hermans C, Hammond JP, White PJ, Verbruggen N. How do plants respond to nutrient shortage by biomass allocation?. Trends in plant science. 2006 Dec 1;11(12):610-7.'},{id:"B22",body:'Hussain M, Farooq S, Hasan W, Ul-Allah S, Tanveer M, Farooq M, Nawaz A. Drought stress in sunflower: Physiological effects and its management through breeding and agronomic alternatives. Agricultural water management. 2018 Mar 31;201:152-66.'},{id:"B23",body:'Prasad PV, Staggenborg SA, Ristic Z. Impacts of drought and/or heat stress on physiological, developmental, growth, and yield processes of crop plants. Response of crops to limited water: Understanding and modeling water stress effects on plant growth processes. 2008 Dec 22;1:301-55.'},{id:"B24",body:'Chakraborty D, Nagarajan S, Aggarwal P, Gupta VK, Tomar RK, Garg RN, Sahoo RN, Sarkar A, Chopra UK, Sarma KS, Kalra N. Effect of mulching on soil and plant water status, and the growth and yield of wheat (Triticum aestivum L.) in a semi-arid environment. Agricultural water management. 2008 Dec 1;95(12):1323-34.'},{id:"B25",body:'Noor MA. Nitrogen management and regulation for optimum NUE in maize–A mini review. Cogent Food & Agriculture. 2017 Jan 1;3(1):1348214.'},{id:"B26",body:'Tripathi DK, Singh VP, Chauhan DK, Sharma S, Prasad SM, Dubey NK, Ramawat N, editors. Plant Life under Changing Environment: Responses and Management. Academic Press; 2020 Apr 21.'},{id:"B27",body:'Santander C, Aroca R, Ruiz-Lozano JM, Olave J, Cartes P, Borie F, Cornejo P. Arbuscular mycorrhiza effects on plant performance under osmotic stress. Mycorrhiza. 2017 Oct 1;27(7):639-57.'},{id:"B28",body:'Abid M, Tian Z, Zahoor R, Ata-Ul-Karim ST, Daryl C, Snider JL, Dai T. Pre-Drought Priming: A Key Drought Tolerance Engine in Support of Grain Development in Wheat. InAdvances in agronomy 2018 Jan 1 (Vol. 152, pp. 51-85). Academic Press.'},{id:"B29",body:'Spiertz JH. Nitrogen, sustainable agriculture and food security: a review. InSustainable agriculture 2009 (pp. 635-651). Springer, Dordrecht.'},{id:"B30",body:'Ahmad Z, Waraich EA, Akhtar S, Anjum S, Ahmad T, Mahboob W, Hafeez OB, Tapera T, Labuschagne M, Rizwan M. Physiological responses of wheat to drought stress and its mitigation approaches. Acta Physiologiae Plantarum. 2018 Apr 1;40(4):80.'},{id:"B31",body:'Blum A. Plant water relations, plant stress and plant production. InPlant breeding for water-limited environments 2011 (pp. 11-52). Springer, New York, NY.'},{id:"B32",body:'Zang U, Goisser M, Häberle KH, Matyssek R, Matzner E, Borken W. Effects of drought stress on photosynthesis, rhizosphere respiration, and fine-root characteristics of beech saplings: A rhizotron field study. Journal of plant nutrition and soil science. 2014 Apr;177(2):168-77.'},{id:"B33",body:'Zhang X, Wang Y, Sun H, Chen S, Shao L. Optimizing the yield of winter wheat by regulating water consumption during vegetative and reproductive stages under limited water supply. Irrigation Science. 2013 Sep 1;31(5):1103-12.'},{id:"B34",body:'Mega R, Abe F, Kim JS, Tsuboi Y, Tanaka K, Kobayashi H, Sakata Y, Hanada K, Tsujimoto H, Kikuchi J, Cutler SR. Tuning water-use efficiency and drought tolerance in wheat using abscisic acid receptors. Nature plants. 2019 Feb;5(2):153-9.'},{id:"B35",body:'Bais HP, Weir TL, Perry LG, Gilroy S, Vivanco JM. The role of root exudates in rhizosphere interactions with plants and other organisms. Annu. Rev. Plant Biol. 2006 Jun 2;57:233-66.'},{id:"B36",body:'Ackerly D. Functional strategies of chaparral shrubs in relation to seasonal water deficit and disturbance. Ecological Monographs. 2004 Feb;74(1):25-44.'},{id:"B37",body:'Dijkstra FA, Cheng W. Moisture modulates rhizosphere effects on C decomposition in two different soil types. Soil Biology and Biochemistry. 2007 Sep 1;39(9):2264-74.'},{id:"B38",body:'Freschet GT, Swart EM, Cornelissen JH. Integrated plant phenotypic responses to contrasting above-and below-ground resources: Key roles of specific leaf area and root mass fraction. New Phytologist. 2015 Jun;206(4):1247-60.'},{id:"B39",body:'Li SX, Wang ZH, Hu TT, Gao YJ, Stewart BA. Nitrogen in dryland soils of China and its management. Advances in Agronomy. 2009 Jan 1;101:123-81.'},{id:"B40",body:'Kamran M, Shahbaz M, Ashraf M, Akram NA. Alleviation of drought-induced adverse effects in spring wheat (Triticum aestivum L.) using proline as a pre-sowing seed treatment. Pak. J. Bot. 2009 Apr 1;41(2):621-32.'},{id:"B41",body:'Hawkesford MJ. Reducing the reliance on nitrogen fertilizer for wheat production. Journal of cereal science. 2014 May 1;59(3):276-83.'},{id:"B42",body:'Husen A, Iqbal M, Aref IM. Plant growth and foliar characteristics of faba bean (Vicia faba L.) as affected by indole-acetic acid under water-sufficient and water-deficient conditions. Journal of Environmental Biology. 2017 Mar 1;38(2):179.'},{id:"B43",body:'Abid M, Tian Z, Ata-Ul-Karim ST, Cui Y, Liu Y, Zahoor R, Jiang D, Dai T. Nitrogen nutrition improves the potential of wheat (Triticum aestivum L.) to alleviate the effects of drought stress during vegetative growth periods. Frontiers in plant science. 2016 Jun 30;7:981.'},{id:"B44",body:'Reich PB, Hobbie SE, Lee T, Ellsworth DS, West JB, Tilman D, Knops JM, Naeem S, Trost J. Nitrogen limitation constrains sustainability of ecosystem response to CO 2. Nature. 2006 Apr;440(7086):922-5.'},{id:"B45",body:'Yin L, Xu H, Dong S, Chu J, Dai X, He M. Optimised nitrogen allocation favours improvement in canopy photosynthetic nitrogen-use efficiency: Evidence from late-sown winter wheat. Environmental and Experimental Botany. 2019 Mar 1;159:75-86.'},{id:"B46",body:'Moyano FE, Manzoni S, Chenu C. Responses of soil heterotrophic respiration to moisture availability: An exploration of processes and models. Soil Biology and Biochemistry. 2013 Apr 1;59:72-85.'},{id:"B47",body:'Below FE. Nitrogen metabolism and crop productivity. Handbook of plant and crop physiology. 2002;2:385-406'},{id:"B48",body:'Ashraf M, Akram NA, Al-Qurainy F, Foolad MR. Drought tolerance: roles of organic osmolytes, growth regulators, and mineral nutrients. InAdvances in Agronomy 2011 Jan 1 (Vol. 111, pp. 249-296). Academic Press.'},{id:"B49",body:'Kurepin LV, Ivanov AG, Zaman M, Pharis RP, Allakhverdiev SI, Hurry V, Hüner NP. Stress-related hormones and glycinebetaine interplay in protection of photosynthesis under abiotic stress conditions. Photosynthesis research. 2015 Dec 1;126(2-3):221-35.'},{id:"B50",body:'Reddy AR, Chaitanya KV, Vivekanandan M. Drought-induced responses of photosynthesis and antioxidant metabolism in higher plants. Journal of plant physiology. 2004 Nov 18;161(11):1189-202.'},{id:"B51",body:'Chen H, Jiang JG. Osmotic adjustment and plant adaptation to environmental changes related to drought and salinity. Environmental Reviews. 2010 Dec;18(NA):309-19.'},{id:"B52",body:'Hayat S, Hayat Q , Alyemeni MN, Wani AS, Pichtel J, Ahmad A. Role of proline under changing environments: a review. Plant signaling & behavior. 2012 Nov 1;7(11):1456-66.'},{id:"B53",body:'Wassmann R, Jagadish SV, Heuer S, Ismail A, Redona E, Serraj R, Singh RK, Howell G, Pathak H, Sumfleth K. Climate change affecting rice production: the physiological and agronomic basis for possible adaptation strategies. Advances in agronomy. 2009 Jan 1;101:59-122.'},{id:"B54",body:'Ullah A, Manghwar H, Shaban M, Khan AH, Akbar A, Ali U, Ali E, Fahad S. Phytohormones enhanced drought tolerance in plants: a coping strategy. Environmental Science and Pollution Research. 2018 Nov 1;25(33):33103-18.'},{id:"B55",body:'Pei ZM, Kuchitsu K. Early ABA signaling events in guard cells. Journal of Plant Growth Regulation. 2005 Dec 1;24(4):296-307.'},{id:"B56",body:'Marcińska I, Czyczyło-Mysza I, Skrzypek E, Filek M, Grzesiak S, Grzesiak MT, Janowiak F, Hura T, Dziurka M, Dziurka K, Nowakowska A. Impact of osmotic stress on physiological and biochemical characteristics in drought-susceptible and drought-resistant wheat genotypes. Acta physiologiae plantarum. 2013 Feb 1;35(2):451-61.'},{id:"B57",body:'Hong-Bo S, Xiao-Yan C, Li-Ye C, Xi-Ning Z, Gang W, Yong-Bing Y, Chang-Xing Z, Zan-Min H. Investigation on the relationship of proline with wheat anti-drought under soil water deficits. Colloids and Surfaces B: Biointerfaces. 2006 Nov 1;53(1):113-9.'},{id:"B58",body:'Ullah A, Manghwar H, Shaban M, Khan AH, Akbar A, Ali U, Ali E, Fahad S. Phytohormones enhanced drought tolerance in plants: a coping strategy. Environmental Science and Pollution Research. 2018 Nov 1;25(33):33103-18.'},{id:"B59",body:'Chakraborty U, Pradhan B. Oxidative stress in five wheat varieties (Triticum aestivum L.) exposed to water stress and study of their antioxidant enzyme defense system, water stress responsive metabolites and H2O2 accumulation. Brazilian Journal of Plant Physiology. 2012 Jun;24(2):117-30.'},{id:"B60",body:'Cattivelli L, Rizza F, Badeck FW, Mazzucotelli E, Mastrangelo AM, Francia E, Marè C, Tondelli A, Stanca AM. Drought tolerance improvement in crop plants: an integrated view from breeding to genomics. Field crops research. 2008 Jan 2;105(1-2):1-4.'},{id:"B61",body:'Wang JY, Xiong YC, Li FM, Siddique KH, Turner NC. Effects of drought stress on morphophysiological traits, biochemical characteristics, yield, and yield components in different ploidy wheat: A meta-analysis. InAdvances in agronomy 2017 Jan 1 (Vol. 143, pp. 139-173). Academic Press.'},{id:"B62",body:'Mwadzingeni L, Shimelis H, Tesfay S, Tsilo TJ. Screening of bread wheat genotypes for drought tolerance using phenotypic and proline analyses. Frontiers in plant science. 2016 Aug 25;7:1276.'},{id:"B63",body:'Hafez EM, Gharib HS. Effect of exogenous application of ascorbic acid on physiological and biochemical characteristics of wheat under water stress. Int. J. Plant Prod. 2016 Oct 1;10(4):579-96.'},{id:"B64",body:'Samarah NH, Alqudah AM, Amayreh JA, McAndrews GM. The effect of late-terminal drought stress on yield components of four barley cultivars. Journal of Agronomy and Crop Science. 2009 Dec;195(6):427-41.'},{id:"B65",body:'Suneja Y, Gupta AK, Bains NS. Stress adaptive plasticity: Aegilops tauschii and Triticum dicoccoides as potential donors of drought associated morpho-physiological traits in wheat. Frontiers in Plant Science. 2019 Feb 25;10:211.'},{id:"B66",body:'Wang JY, Xiong YC, Li FM, Siddique KH, Turner NC. Effects of drought stress on morphophysiological traits, biochemical characteristics, yield, and yield components in different ploidy wheat: A meta-analysis. InAdvances in agronomy 2017 Jan 1 (Vol. 143, pp. 139-173). Academic Press.'},{id:"B67",body:'Farooq M, Gogoi N, Barthakur S, Baroowa B, Bharadwaj N, Alghamdi SS, Siddique KH. Drought stress in grain legumes during reproduction and grain filling. Journal of Agronomy and Crop Science. 2017 Apr;203(2):81-102.'},{id:"B68",body:'Mancosu N, Snyder RL, Kyriakakis G, Spano D. Water scarcity and future challenges for food production. Water. 2015 Mar;7(3):975-92.'},{id:"B69",body:'Driever SM, Lawson T, Andralojc PJ, Raines CA, Parry MA. Natural variation in photosynthetic capacity, growth, and yield in 64 field-grown wheat genotypes. Journal of Experimental Botany. 2014 Sep 1;65(17):4959-73.'},{id:"B70",body:'Blum A. Drought resistance, water-use efficiency, and yield potential—are they compatible, dissonant, or mutually exclusive?. Australian Journal of Agricultural Research. 2005 Dec 20;56(11):1159-68.'},{id:"B71",body:'Waraich EA, Ahmad R, Ashraf MY, Saifullah, Ahmad M. Improving agricultural water use efficiency by nutrient management in crop plants. Acta Agriculturae Scandinavica, Section B-Soil & Plant Science. 2011 May 1;61(4):291-304.'},{id:"B72",body:'Tavakkoli AR, Oweis TY. The role of supplemental irrigation and nitrogen in producing bread wheat in the highlands of Iran. Agricultural Water Management. 2004 Mar 15;65(3):225-36.'},{id:"B73",body:'Trethowan RM, Reynolds M, Sayre K, Ortiz-Monasterio I. Adapting wheat cultivars to resource conserving farming practices and human nutritional needs. Annals of applied biology. 2005 Jul;146(4):405-13.'},{id:"B74",body:'Johnson JF, Allmaras RR, Reicosky DC. Estimating source carbon from crop residues, roots and rhizodeposits using the national grain-yield database. Agronomy journal. 2006 May;98(3):622-36.'},{id:"B75",body:'Ali H, Iqbal N, Shahzad AN, Sarwar N, Ahmad S, Mehmood A. Seed priming improves irrigation water use efficiency, yield, and yield components of late-sown wheat under limited water conditions. Turkish Journal of Agriculture and forestry. 2013 Sep 17;37(5):534-44.'},{id:"B76",body:'Hatfield JL, Sauer TJ, Prueger JH. Managing soils to achieve greater water use efficiency: a review. Agronomy journal. 2001 Mar;93(2):271-80.'},{id:"B77",body:'Chauhan BS. Weed ecology and weed management strategies for dry-seeded rice in Asia. Weed Technology. 2012 Jan;26(1):1-3.'},{id:"B78",body:'Debaeke P, Aboudrare A. Adaptation of crop management to water-limited environments. European Journal of Agronomy. 2004 Dec 1;21(4):433-46.'},{id:"B79",body:'Li Y, Li H, Li Y, Zhang S. Improving water-use efficiency by decreasing stomatal conductance and transpiration rate to maintain higher ear photosynthetic rate in drought-resistant wheat. The Crop Journal. 2017 Jun 1;5(3):231-9.'},{id:"B80",body:'Timmusk S, Abd El-Daim IA, Copolovici L, Tanilas T, Kännaste A, Behers L, Nevo E, Seisenbaeva G, Stenström E, Niinemets Ü. Drought-tolerance of wheat improved by rhizosphere bacteria from harsh environments: enhanced biomass production and reduced emissions of stress volatiles. PloS one. 2014 May 8;9(5):e96086.'},{id:"B81",body:'Abd El-Mageed TA, El-Samnoudi IM, Ibrahim AE, Abd El Tawwab AR. Compost and mulching modulates morphological, physiological responses and water use efficiency in sorghum (bicolor L. Moench) under low moisture regime. Agricultural Water Management. 2018 Sep 30;208:431-9.'},{id:"B82",body:'Ogle SM, Alsaker C, Baldock J, Bernoux M, Breidt FJ, McConkey B, Regina K, Vazquez-Amabile GG. Climate and soil characteristics determine where no-till management can store carbon in soils and mitigate greenhouse gas emissions. Scientific reports. 2019 Aug 12;9(1):1-8.'},{id:"B83",body:'Mohanty M, Sinha NK, Painuli DK, Bandyopadhyay KK, Hati KM, Reddy KS, Chaudhary RS. Modelling soil water contents at field capacity and permanent wilting point using artificial neural network for Indian soils. National Academy Science Letters. 2015 Oct 1;38(5):373-7.'},{id:"B84",body:'He T, Gao F, Liang S, Peng Y. Mapping climatological bare soil albedos over the contiguous United States using MODIS data. Remote Sensing. 2019 Jan;11(6):666.'},{id:"B85",body:'Li Liu D, Zeleke KT, Wang B, Macadam I, Scott F, Martin RJ. Crop residue incorporation can mitigate negative climate change impacts on crop yield and improve water use efficiency in a semiarid environment. European Journal of Agronomy. 2017 Apr 1;85:51-68.'},{id:"B86",body:'Patanè C. Leaf area index, leaf transpiration and stomatal conductance as affected by soil water deficit and VPD in processing tomato in semi arid Mediterranean climate. Journal of Agronomy and Crop Science. 2011 Jun;197(3):165-76.'},{id:"B87",body:'Papanatsiou M, Petersen J, Henderson L, Wang Y, Christie JM, Blatt MR. Optogenetic manipulation of stomatal kinetics improves carbon assimilation, water use, and growth. Science. 2019 Mar 29;363(6434):1456-9.'},{id:"B88",body:'Bertolino LT, Caine RS, Gray JE. Impact of stomatal density and morphology on water-use efficiency in a changing world. Frontiers in plant science. 2019 Mar 6;10:225.'},{id:"B89",body:'Casson SA, Hetherington AM. Environmental regulation of stomatal development. Current opinion in plant biology. 2010 Feb 1;13(1):90-5.'},{id:"B90",body:'Nadeau JA. Stomatal development: new signals and fate determinants. Current opinion in plant biology. 2009 Feb 1;12(1):29-35.'},{id:"B91",body:'Sibbernsen E, Mott KA. Stomatal responses to flooding of the intercellular air spaces suggest a vapor-phase signal between the mesophyll and the guard cells. Plant physiology. 2010 Jul 1;153(3):1435-42.'},{id:"B92",body:'Franks PJ, Farquhar GD. The mechanical diversity of stomata and its significance in gas-exchange control. Plant physiology. 2007 Jan 1;143(1):78-87.'},{id:"B93",body:'Tardieu F. Plant response to environmental conditions: assessing potential production, water demand, and negative effects of water deficit. Frontiers in physiology. 2013 Feb 18;4:17.'},{id:"B94",body:'Richards RA. Physiological traits used in the breeding of new cultivars for water-scarce environments. Agricultural water management. 2006 Feb 24;80(1-3):197-211.'},{id:"B95",body:'Wasaya A, Zhang X, Fang Q , Yan Z. Root phenotyping for drought tolerance: a review. Agronomy. 2018 Nov;8(11):241.'},{id:"B96",body:'Maeght JL, Rewald B, Pierret A. How to study deep roots—and why it matters. Frontiers in plant science. 2013 Aug 13;4:299.'},{id:"B97",body:'Farooq M, Hussain M, Siddique KH. Drought stress in wheat during flowering and grain-filling periods. Critical Reviews in Plant Sciences. 2014 Jul 4;33(4):331-49.'},{id:"B98",body:'Schoppach R, Wauthelet D, Jeanguenin L, Sadok W. Conservative water use under high evaporative demand associated with smaller root metaxylem and limited trans-membrane water transport in wheat. Functional Plant Biology. 2014 Mar 4;41(3):257-69.'},{id:"B99",body:'Brisson N, Mary B, Ripoche D, Jeuffroy MH, Ruget F, Nicoullaud B, Gate P, Devienne-Barret F, Antonioletti R, Durr C, Richard G. STICS: a generic model for the simulation of crops and their water and nitrogen balances. I. Theory and parameterization applied to wheat and corn.'},{id:"B100",body:'Vangronsveld J, Herzig R, Weyens N, Boulet J, Adriaensen K, Ruttens A, Thewys T, Vassilev A, Meers E, Nehnevajova E, van der Lelie D. Phytoremediation of contaminated soils and groundwater: lessons from the field. Environmental Science and Pollution Research. 2009 Nov 1;16(7):765-94.'},{id:"B101",body:'Milly PC, Dunne KA, Vecchia AV. Global pattern of trends in streamflow and water availability in a changing climate. Nature. 2005 Nov;438(7066):347-50.'},{id:"B102",body:'Sylvester-Bradley R, Kindred DR. Analysing nitrogen responses of cereals to prioritize routes to the improvement of nitrogen use efficiency. Journal of Experimental Botany. 2009 May 1;60(7):1939-51.'},{id:"B103",body:'Quemada M, Gabriel JL. Approaches for increasing nitrogen and water use efficiency simultaneously. Global Food Security. 2016 Jun 1;9:29-35.'},{id:"B104",body:'Wang X, Dai K, Zhang D, Zhang X, Wang Y, Zhao Q , Cai D, Hoogmoed WB, Oenema O. Dryland maize yields and water use efficiency in response to tillage/crop stubble and nutrient management practices in China. Field Crops Research. 2011 Jan 14;120(1):47-57.'},{id:"B105",body:'Hirel B, Tétu T, Lea PJ, Dubois F. Improving nitrogen use efficiency in crops for sustainable agriculture. Sustainability. 2011 Sep;3(9):1452-85.'},{id:"B106",body:'Bowles TM, Mooshammer M, Socolar Y, Calderón F, Cavigelli MA, Culman SW, Deen W, Drury CF, y Garcia AG, Gaudin AC, Harkcom WS. Long-Term evidence shows that crop-rotation Diversification increases agricultural resilience to Adverse Growing conditions in North America. One Earth. 2020 Mar 6.'},{id:"B107",body:'Saikia SP, Jain V. Biological nitrogen fixation with non-legumes: An achievable target or a dogma?. Current science. 2007 Feb 10:317-22.'},{id:"B108",body:'Dawson JC, Huggins DR, Jones SS. Characterizing nitrogen use efficiency in natural and agricultural ecosystems to improve the performance of cereal crops in low-input and organic agricultural systems. Field Crops Research. 2008 May 10;107(2):89-101.'},{id:"B109",body:'Dawson JC, Huggins DR, Jones SS. Characterizing nitrogen use efficiency in natural and agricultural ecosystems to improve the performance of cereal crops in low-input and organic agricultural systems. Field Crops Research. 2008 May 10;107(2):89-101.'},{id:"B110",body:'Fang QX, Ma L, Green TR, Yu Q , Wang TD, Ahuja LR. Water resources and water use efficiency in the North China Plain: Current status and agronomic management options. Agricultural Water Management. 2010 Aug 1;97(8):1102-16.'},{id:"B111",body:'Jat ML, Dagar JC, Sapkota TB, Govaerts B, Ridaura SL, Saharawat YS, Sharma RK, Tetarwal JP, Jat RK, Hobbs H, Stirling C. Climate change and agriculture: adaptation strategies and mitigation opportunities for food security in South Asia and Latin America. InAdvances in agronomy 2016 Jan 1 (Vol. 137, pp. 127-235). Academic Press.'},{id:"B112",body:'Chai Q , Gan Y, Zhao C, Xu HL, Waskom RM, Niu Y, Siddique KH. Regulated deficit irrigation for crop production under drought stress. A review. Agronomy for sustainable development. 2016 Mar 1;36(1):3.'},{id:"B113",body:'Rochette P, MacDonald JD, Angers DA, Chantigny MH, Gasser MO, Bertrand N. Banding of urea increased ammonia volatilization in a dry acidic soil. Journal of Environmental Quality. 2009 Jul;38(4):1383-90.'},{id:"B114",body:'Bukola D, Zaid A, Olalekan EI, Falilu A. Consequences of anthropogenic activities on fish and the aquatic environment. Poultry, Fisheries & Wildlife Sciences. 2015 Aug 28.'},{id:"B115",body:'Naz MY, Sulaiman SA. Slow release coating remedy for nitrogen loss from conventional urea: a review. Journal of Controlled Release. 2016 Mar 10;225:109-20.'},{id:"B116",body:'Xu G, Fan X, Miller AJ. Plant nitrogen assimilation and use efficiency. Annual review of plant biology. 2012 Jun 2;63:153-82.'},{id:"B117",body:'Snyder CS, Bruulsema TW, Jensen TL, Fixen PE. Review of greenhouse gas emissions from crop production systems and fertilizer management effects. Agriculture, Ecosystems & Environment. 2009 Oct 1;133(3-4):247-66.'},{id:"B118",body:'Fageria NK, Baligar VC, Li YC. The role of nutrient efficient plants in improving crop yields in the twenty first century. Journal of plant nutrition. 2008 May 30;31(6):1121-57.'},{id:"B119",body:'Andrews M, Raven JA, Sprent JI. Environmental effects on dry matter partitioning between shoot and root of crop plants: relations with growth and shoot protein concentration. Annals of Applied Biology. 2001 Feb;138(1):57-68.'},{id:"B120",body:'Bonifas KD, Walters DT, Cassman KG, Lindquist JL. Nitrogen supply affects root: shoot ratio in corn and velvetleaf (Abutilon theophrasti). Weed Science. 2005 Sep;53(5):670-5.'},{id:"B121",body:'Feldman M, Levy AA. Origin and evolution of wheat and related Triticeae species. InAlien introgression in Wheat 2015 (pp. 21-76). Springer, Cham.'},{id:"B122",body:'Jiang L, Dai T, Jiang D, Cao W, Gan X, Wei S. Characterizing physiological N-use efficiency as influenced by nitrogen management in three rice cultivars. Field Crops Research. 2004 Aug 10;88(2-3):239-50.'},{id:"B123",body:'Ciampitti IA, Vyn TJ. Physiological perspectives of changes over time in maize yield dependency on nitrogen uptake and associated nitrogen efficiencies: A review. Field Crops Research. 2012 Jul 11;133:48-67.'},{id:"B124",body:'Iqbal A, Qiang D, Alamzeb M, Xiangru W, Huiping G, Hengheng Z, Nianchang P, Xiling Z, Meizhen S. Untangling the molecular mechanisms and functions of nitrate to improve nitrogen use efficiency. Journal of the Science of Food and Agriculture. 2020 Feb;100(3):904-14.'},{id:"B125",body:'Garnett T, Plett D, Heuer S, Okamoto M. Genetic approaches to enhancing nitrogen-use efficiency (NUE) in cereals: challenges and future directions. Functional Plant Biology. 2015 Oct 6;42(10):921-41.'},{id:"B126",body:'Ju C, Buresh RJ, Wang Z, Zhang H, Liu L, Yang J, Zhang J. Root and shoot traits for rice varieties with higher grain yield and higher nitrogen use efficiency at lower nitrogen rates application. Field Crops Research. 2015 Apr 1;175:47-55.'},{id:"B127",body:'Sapkota TB, Majumdar K, Jat ML, Kumar A, Bishnoi DK, McDonald AJ, Pampolino M. Precision nutrient management in conservation agriculture based wheat production of Northwest India: Profitability, nutrient use efficiency and environmental footprint. Field Crops Research. 2014 Jan 1;155:233-44.'},{id:"B128",body:'Singh Y, Sidhu HS. Management of cereal crop residues for sustainable rice-wheat production system in the Indo-Gangetic plains of India. Proceedings of the Indian National Science Academy. 2014 Mar;80(1):95-114.'},{id:"B129",body:'Madhu M, Hatfield JL. Interaction of carbon dioxide enrichment and soil moisture on photosynthesis, transpiration, and water use efficiency of soybean. Agricultural Sciences. 2014 Apr 3;2014.'},{id:"B130",body:'Ye Y, Liang X, Chen Y, Liu J, Gu J, Guo R, Li L. Alternate wetting and drying irrigation and controlled-release nitrogen fertilizer in late-season rice. Effects on dry matter accumulation, yield, water and nitrogen use. Field Crops Research. 2013 Mar 20;144:212-24.'},{id:"B131",body:'Albrizio R, Todorovic M, Matic T, Stellacci AM. Comparing the interactive effects of water and nitrogen on durum wheat and barley grown in a Mediterranean environment. Field Crops Research. 2010 Jan 20;115(2):179-90.'},{id:"B132",body:'Kahiluoto H, Kaseva J, Balek J, Olesen JE, Ruiz-Ramos M, Gobin A, Kersebaum KC, Takáč J, Ruget F, Ferrise R, Bezak P. Decline in climate resilience of European wheat. Proceedings of the National Academy of Sciences. 2019 Jan 2;116(1):123-8.'},{id:"B133",body:'Aulakh MS. Nitrogen losses and fertilizer N use efficiency in irrigated porous soils. Nutrient cycling in agroecosystems. 1996 Oct 1;47(3):197-212.'},{id:"B134",body:'Mo X, Liu S, Lin Z, Guo R. Regional crop yield, water consumption and water use efficiency and their responses to climate change in the North China Plain. Agriculture, Ecosystems & Environment. 2009 Nov 1;134(1-2):67-78.'},{id:"B135",body:'Grizzetti B, Bouraoui F, Billen G, van Grinsven H, Cardoso AC, Thieu V, Garnier J, Curtis C, Howarth RW, Johnes P. Nitrogen as a threat to European water quality.'},{id:"B136",body:'Adnan M, Zahir S, Fahad S, Arif M, Mukhtar A, Imtiaz AK, Ishaq AM, Abdul B, Hidayat U, Muhammad A, Inayat-Ur R. Phosphate-solubilizing bacteria nullify the antagonistic effect of soil calcification on bioavailability of phosphorus in alkaline soils. Sci Rep 8: 4339.'},{id:"B137",body:'Ahmad S, Kamran M, Ding R, Meng X, Wang H, Ahmad I, Fahad S, Han Q . Exogenous melatonin confers drought stress by promoting plant growth, photosynthetic capacity and antioxidant defense system of maize seedlings. PeerJ. 2019 Oct 11;7:e7793.'},{id:"B138",body:'Akram R, Turan V, Hammad HM, Ahmad S, Hussain S, Hasnain A, Maqbool MM, Rehmani MI, Rasool A, Masood N, Mahmood F. Fate of organic and inorganic pollutants in paddy soils. InEnvironmental pollution of paddy soils 2018 (pp. 197-214). Springer, Cham.'},{id:"B139",body:'Akram R, Turan V, Wahid A, Ijaz M, Shahid MA, Kaleem S, Hafeez A, Maqbool MM, Chaudhary HJ, Munis MF, Mubeen M. Paddy land pollutants and their role in climate change. InEnvironmental Pollution of Paddy Soils 2018 (pp. 113-124). Springer, Cham.'},{id:"B140",body:'Khan A, Tan DK, Munsif F, Afridi MZ, Shah F, Wei F, Fahad S, Zhou R. Nitrogen nutrition in cotton and control strategies for greenhouse gas emissions: a review. Environmental Science and Pollution Research. 2017 Oct 1;24(30):23471-87.'},{id:"B141",body:'Khan A, Tan DK, Afridi MZ, Luo H, Tung SA, Ajab M, Fahad S. Nitrogen fertility and abiotic stresses management in cotton crop: a review. Environmental Science and Pollution Research. 2017 Jun 1;24(17):14551-66.'},{id:"B142",body:'Muhammad B, Adnan M, Munsif F, Fahad S, Saeed M, Wahid F, Arif M, Amanullah J, Wang D, Saud S, Noor M. Substituting urea by organic wastes for improving maize yield in alkaline soil. Journal of Plant Nutrition. 2019 Nov 26;42(19):2423-34.'},{id:"B143",body:'Wang D, Fahad S, Saud S, Kamran M, Khan A, Khan MN, Hammad HM, Nasim W. Morphological acclimation to agronomic manipulation in leaf dispersion and orientation to promote “Ideotype” breeding: Evidence from 3D visual modeling of “super” rice (Oryza sativa L.). Plant Physiology and Biochemistry. 2019 Feb 1;135:499-510.'},{id:"B144",body:'Adnan M, Fahad S, Zamin M, Shah S, Mian IA, Danish S, Zafar-ul-Hye M, Battaglia ML, Naz RM, Saeed B, Saud S. Coupling phosphate-solubilizing bacteria with phosphorus supplements improve maize phosphorus acquisition and growth under lime induced salinity stress. Plants. 2020 Jul;9(7):900.'},{id:"B145",body:'Adnan M, Fahad S, Khan IA, Saeed M, Ihsan MZ, Saud S, Riaz M, Wang D, Wu C. Integration of poultry manure and phosphate solubilizing bacteria improved availability of Ca bound P in calcareous soils. 3 Biotech. 2019 Oct 1;9(10):368.'},{id:"B146",body:'Adnan M, Shah Z, Sharif M, Rahman H. Liming induces carbon dioxide (CO 2) emission in PSB inoculated alkaline soil supplemented with different phosphorus sources. Environmental Science and Pollution Research. 2018 Apr 1;25(10):9501-9.'},{id:"B147",body:'Fahad S, Bajwa AA, Nazir U, Anjum SA, Farooq A, Zohaib A, Sadia S, Nasim W, Adkins S, Saud S, Ihsan MZ. Crop production under drought and heat stress: plant responses and management options. Frontiers in plant science. 2017 Jun 29;8:1147.'},{id:"B148",body:'Fahad S, Bano A (2012) Effect of salicylic acid on physiological and biochemical characterization of maize grown in saline area. Pak J Bot 44:1433-1438'},{id:"B149",body:'Fahad S, Chen Y, Saud S,Wang K, Xiong D, Chen C,Wu C, Shah F, Nie L, Huang J (2013) Ultraviolet radiation effect on photosynthetic pigments, biochemical attributes, antioxidant enzyme activity and hormonal contents of wheat. J Food, Agri Environ 11(3&4):1635-1641'},{id:"B150",body:'Fahad S, Hussain S, Bano A, Saud S, Hassan S, Shan D, Khan FA, Khan F, Chen Y, Wu C, Tabassum MA. Potential role of phytohormones and plant growth-promoting rhizobacteria in abiotic stresses: consequences for changing environment. Environmental Science and Pollution Research. 2015 Apr 1;22(7):4907-21.'},{id:"B151",body:'Fahad S, Hussain S, Matloob A, Khan FA, Khaliq A, Saud S, Hassan S, Shan D, Khan F, Ullah N, Faiq M. Phytohormones and plant responses to salinity stress: a review. Plant growth regulation. 2015 Mar 1;75(2):391-404.'},{id:"B152",body:'Abbas F, Hammad HM, Ishaq W, Farooque AA, Bakhat HF, Zia Z, Fahad S, Farhad W, Cerdà A. A review of soil carbon dynamics resulting from agricultural practices. Journal of environmental management. 2020 Aug 15;268:110319.'},{id:"B153",body:'Gul F, Ahmed I, Ashfaq M, Jan D, Fahad S, Li X, Wang D, Fahad M, Fayyaz M, Shah SA. Use of crop growth model to simulate the impact of climate change on yield of various wheat cultivars under different agro-environmental conditions in Khyber Pakhtunkhwa, Pakistan. Arabian Journal of Geosciences. 2020 Feb 1;13(3):112.'},{id:"B154",body:'Rahman MH, Ahmad A, Wajid A, Hussain M, Rasul F, Ishaque W, Islam MA, Shelia V, Awais M, Ullah A, Wahid A. Application of CSM-CROPGRO-Cotton model for cultivars and optimum planting dates: evaluation in changing semi-arid climate. Field Crops Research. 2019 May 15;238:139-52.'},{id:"B155",body:'Hammad HM, Khaliq A, Abbas F, Farhad W, Fahad S, Aslam M, Shah GM, Nasim W, Mubeen M, Bakhat HF. Comparative Effects of Organic and Inorganic Fertilizers on Soil Organic Carbon and Wheat Productivity under Arid Region. Communications in Soil Science and Plant Analysis. 2020 May 30;51(10):1406-22.'},{id:"B156",body:'Hammad HM, Abbas F, Ahmad A, Bakhat HF, Farhad W, Wilkerson CJ, Fahad S, Hoogenboom G. Predicting Kernel Growth of Maize under Controlled Water and Nitrogen Applications. International Journal of Plant Production. 2020 Aug 19:1-2.'},{id:"B157",body:'Khan MN, Zhang J, Luo T, Liu J, Ni F, Rizwan M, Fahad S, Hu L. Morpho-physiological and biochemical responses of tolerant and sensitive rapeseed cultivars to drought stress during early seedling growth stage. Acta Physiologiae Plantarum. 2019 Feb 1;41(2):25.'},{id:"B158",body:'Fahad S, Hussain S, Saud S, Hassan S, Chauhan BS, Khan F, Ihsan MZ, Ullah A, Wu C, Bajwa AA, Alharby H. Responses of rapid viscoanalyzer profile and other rice grain qualities to exogenously applied plant growth regulators under high day and high night temperatures. PLoS One. 2016 Jul 29;11(7):e0159590.'},{id:"B159",body:'Fahad S, Hussain S, Saud S, Hassan S, Ihsan Z, Shah AN, Wu C, Yousaf M, Nasim W, Alharby H, Alghabari F. Exogenously applied plant growth regulators enhance the morpho-physiological growth and yield of rice under high temperature. Frontiers in Plant Science. 2016 Aug 30;7:1250.'},{id:"B160",body:'Fahad S, Hussain S, Saud S, Hassan S, Tanveer M, Ihsan MZ, Shah AN, Ullah A, Khan F, Ullah S, Alharby H. A combined application of biochar and phosphorus alleviates heat-induced adversities on physiological, agronomical and quality attributes of rice. Plant physiology and biochemistry. 2016 Jun 1;103:191-8.'},{id:"B161",body:'Fahad S, Hussain S, Saud S, Khan F, Hassan S, Nasim W, Arif M, Wang F, Huang J. Exogenously applied plant growth regulators affect heat-stressed rice pollens. Journal of agronomy and crop science. 2016 Apr;202(2):139-50.'},{id:"B162",body:'Hammad HM, Ashraf M, Abbas F, Bakhat HF, Qaisrani SA, Mubeen M, Fahad S, Awais M. Environmental factors affecting the frequency of road traffic accidents: a case study of sub-urban area of Pakistan. Environmental Science and Pollution Research. 2019 Apr 1;26(12):11674-85.'},{id:"B163",body:'Hammad HM, Farhad W, Abbas F, Fahad S, Saeed S, Nasim W, Bakhat HF. Maize plant nitrogen uptake dynamics at limited irrigation water and nitrogen. Environmental Science and Pollution Research. 2017 Jan 1;24(3):2549-57.'},{id:"B164",body:'Alharby HF, Fahad S. Melatonin application enhances biochar efficiency for drought tolerance in maize varieties: Modifications in physio-biochemical machinery. Agronomy Journal. 2020 Jul;112(4):2826-47.'},{id:"B165",body:'Hussain MA, Fahad S, Sharif R, Jan MF, Mujtaba M, Ali Q , Ahmad A, Ahmad H, Amin N, Ajayo BS, Sun C. Multifunctional role of brassinosteroid and its analogues in plants. Plant Growth Regulation. 2020 Aug 2:1-6.'},{id:"B166",body:'Ilyas M, Nisar M, Khan N, Hazrat A, Khan AH, Hayat K, Fahad S, Khan A, Ullah A. Drought Tolerance Strategies in Plants: A Mechanistic Approach. Journal of Plant Growth Regulation. 2020 Jun 22:1-9.'},{id:"B167",body:'Jan M, Anwar-ul-Haq M, Shah AN, Yousaf M, Iqbal J, Li X, Wang D, Fahad S. Modulation in growth, gas exchange, and antioxidant activities of salt-stressed rice (Oryza sativa L.) genotypes by zinc fertilization. Arabian Journal of Geosciences. 2019 Dec 1;12(24):775.'},{id:"B168",body:'Kamran M, Cui W, Ahmad I, Meng X, Zhang X, Su W, Chen J, Ahmad S, Fahad S, Han Q , Liu T. Effect of paclobutrazol, a potential growth regulator on stalk mechanical strength, lignin accumulation and its relation with lodging resistance of maize. Plant growth regulation. 2018 Mar 1;84(2):317-32.'},{id:"B169",body:'Mubeen M, Ahmad A, Hammad HM, Awais M, Farid HU, Saleem M, Amin A, Ali A, Fahad S, Nasim W. Evaluating the climate change impact on water use efficiency of cotton-wheat in semi-arid conditions using DSSAT model. Journal of Water and Climate Change. 2019 Oct 24.'},{id:"B170",body:'Fahad S, Hussain S, Saud S, Tanveer M, Bajwa AA, Hassan S, Shah AN, Ullah A, Wu C, Khan FA, Shah F. A biochar application protects rice pollen from high-temperature stress. Plant Physiology and Biochemistry. 2015 Nov 1;96:281-7.'},{id:"B171",body:'Fahad S, Ihsan MZ, Khaliq A, Daur I, Saud S, Alzamanan S, Nasim W, Abdullah M, Khan IA, Wu C, Wang D. Consequences of high temperature under changing climate optima for rice pollen characteristics-concepts and perspectives. Archives of Agronomy and Soil Science. 2018 Sep 19;64(11):1473-88.'},{id:"B172",body:'Fahad S, Nie L, Chen Y, Wu C, Xiong D, Saud S, Hongyan L, Cui K, Huang J. Crop plant hormones and environmental stress. InSustainable Agriculture Reviews 2015 (pp. 371-400). Springer, Cham.'},{id:"B173",body:'Fahad S, Adnan M, Hassan S, Saud S, Hussain S, Wu C, Wang D, Hakeem KR, Alharby HF, Turan V, Khan MA. Rice responses and tolerance to high temperature. InAdvances in rice research for abiotic stress tolerance 2019 Jan 1 (pp. 201-224). Woodhead Publishing.'},{id:"B174",body:'Fahad S, Rehman A, Shahzad B, Tanveer M, Saud S, Kamran M, Ihtisham M, Khan SU, Turan V, ur Rahman MH. Rice responses and tolerance to metal/metalloid toxicity. InAdvances in rice research for abiotic stress tolerance 2019 Jan 1 (pp. 299-312). Woodhead Publishing.'},{id:"B175",body:'Zamin M, Khattak AM, Salim AM, Marcum KB, Shakur M, Shah S, Jan I, Fahad S. Performance of Aeluropus lagopoides (mangrove grass) ecotypes, a potential turfgrass, under high saline conditions. Environmental Science and Pollution Research. 2019 May 1;26(13):13410-21.'},{id:"B176",body:'Zaman QU, Aslam Z, Yaseen M, Ihsan MZ, Khaliq A, Fahad S, Bashir S, Ramzani PM, Naeem M. Zinc biofortification in rice: leveraging agriculture to moderate hidden hunger in developing countries. Archives of Agronomy and Soil Science. 2018 Jan 28;64(2):147-61.'},{id:"B177",body:'Rehman M, Fahad S, Saleem MH, Hafeez M, Rahman MH, Liu F, Deng G. Red light optimized physiological traits and enhanced the growth of ramie (Boehmeria nivea L.). Photosynthetica. 2020 Jan 1;58(4):922-31.'},{id:"B178",body:'Hussain S, Mubeen M, Ahmad A, Akram W, Hammad HM, Ali M, Masood N, Amin A, Farid HU, Sultana SR, Fahad S. Using GIS tools to detect the land use/land cover changes during forty years in Lodhran District of Pakistan. Environmental Science and Pollution Research. 2019 Aug 5:1-7.'},{id:"B179",body:'Saleem MH, Fahad S, Adnan M, Ali M, Rana MS, Kamran M, Ali Q , Hashem IA, Bhantana P, Ali M, Hussain RM. Foliar application of gibberellic acid endorsed phytoextraction of copper and alleviates oxidative stress in jute (Corchorus capsularis L.) plant grown in highly copper-contaminated soil of China. Environmental Science and Pollution Research. 2020 Jun 24:1-3.'},{id:"B180",body:'SALEEM M, REHMAN M, FAHAD S, TUNG S, IQBAL N, HASSAN A, AYUB A, WAHID M, SHAUKAT S, LIU L, DENG G. Leaf gas exchange, oxidative stress, and physiological attributes of rapeseed (Brassica napus L.) grown under different light-emitting diodes. PHOTOSYNTHETICA. 2020;58(3):836-45.'},{id:"B181",body:'Izhar Shafi M, Adnan M, Fahad S, Wahid F, Khan A, Yue Z, Danish S, Zafar-ul-Hye M, Brtnicky M, Datta R. Application of Single Superphosphate with Humic Acid Improves the Growth, Yield and Phosphorus Uptake of Wheat (Triticum aestivum L.) in Calcareous Soil. Agronomy. 2020 Sep;10(9):1224.'},{id:"B182",body:'Saleem, M.H., Fahad, S., Khan, S.U., Din, M., Ullah, A., Sabagh, A.E., Hossain, A., Llanes, A. and Liu, L., 2020. Copper-induced oxidative stress, initiation of antioxidants and phytoremediation potential of flax (Linum usitatissimum L.) seedlings grown under the mixing of two different soils of China. Environmental Science and Pollution Research, 27(5), pp.5211-5221.'},{id:"B183",body:'Saud S, Yajun C, Fahad S, Hussain S, Na L, Xin L, Alhussien SA. Silicate application increases the photosynthesis and its associated metabolic activities in Kentucky bluegrass under drought stress and post-drought recovery. Environmental Science and Pollution Research. 2016 Sep 1;23(17):17647-55.'},{id:"B184",body:'Wahid F, Fahad S, Danish S, Adnan M, Yue Z, Saud S, Siddiqui MH, Brtnicky M, Hammerschmiedt T, Datta R. Sustainable Management with Mycorrhizae and Phosphate Solubilizing Bacteria for Enhanced Phosphorus Uptake in Calcareous Soils. Agriculture. 2020 Aug;10(8):334.'},{id:"B185",body:'Saud SH, Chen Y, Long B, Fahad SH, Sadiq AR. The different impact on the growth of cool season turf grass under the various conditions on salinity and draught stress. Int J Agric Sci Res. 2013;3(4):77-84.'},{id:"B186",body:'Watanabe S, Iimori M, Chan DV, Hara E, Kitao H, Maehara Y. MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites. Scientific reports. 2018 Jul 18;8(1):1-0.'},{id:"B187",body:'SaudS F, YajunC I, HammadHM N, JrA A. AlharbyH (2017) Effects of nitrogen supply on water stress and recovery mechanisms in Kentucky Bluegrass plants. Frontiers of Plant Science8.;983.'},{id:"B188",body:'Saud S, Li X, Chen Y, Zhang L, Fahad S, Hussain S, Sadiq A, Chen Y. Silicon application increases drought tolerance of Kentucky bluegrass by improving plant water relations and morphophysiological functions. The Scientific World Journal. 2014 Oct;2014.'},{id:"B189",body:'Shah F, Nie L, Cui K, Shah T, Wu W, Chen C, Zhu L, Ali F, Fahad S, Huang J. Rice grain yield and component responses to near 2 C of warming. Field Crops Research. 2014 Feb 15;157:98-110.'},{id:"B190",body:'Danish S, Zafar-ul-Hye M, Fahad S, Saud S, Brtnicky M, Hammerschmiedt T, Datta R. Drought Stress Alleviation by ACC Deaminase Producing Achromobacter xylosoxidans and Enterobacter cloacae, with and without Timber Waste Biochar in Maize. Sustainability. 2020 Jan;12(15):6286.'},{id:"B191",body:'Tariq M, Ahmad S, Fahad S, Abbas G, Hussain S, Fatima Z, Nasim W, Mubeen M, ur Rehman MH, Khan MA, Adnan M. The impact of climate warming and crop management on phenology of sunflower-based cropping systems in Punjab, Pakistan. Agricultural and Forest Meteorology. 2018 Jun 15;256:270-82.'},{id:"B192",body:'Wajid N, Ashfaq A, Asad A. Muhammad Habib ur R, Veysel T, Fahad S, Suad S, Aziz K, Shahzad A (2017) Radiation efficiency and nitrogen fertilizer impacts on sunflower crop in contrasting environments of Punjab. Pakistan Environ Sci Pollut Res 25: 1822-1836.'},{id:"B193",body:'Wu C, Tang S, Li G, Wang S, Fahad S, Ding Y. Roles of phytohormone changes in the grain yield of rice plants exposed to heat: a review. PeerJ. 2019 Nov 19;7:e7792.'},{id:"B194",body:'Yang Z, Zhang Z, Zhang T, Fahad S, Cui K, Nie L, Peng S, Huang J. The effect of season-long temperature increases on rice cultivars grown in the central and southern regions of China. Frontiers in plant science. 2017 Nov 6;8:1908.'},{id:"B195",body:'Zafar-ul-Hye M, Naeem M, Danish S, Fahad S, Datta R, Abbas M, Rahi AA, Brtnicky M, Holátko J, Tarar ZH, Nasir M. Alleviation of Cadmium Adverse Effects by Improving Nutrients Uptake in Bitter Gourd through Cadmium Tolerant Rhizobacteria. Environments. 2020 Aug;7(8):54.'},{id:"B196",body:'Zafar-ul-Hye M, Tahzeeb-ul-Hassan M, Abid M, Fahad S, Brtnicky M, Dokulilova T, Datta R, Danish S. Potential role of compost mixed biochar with rhizobacteria in mitigating lead toxicity in spinach. Scientific reports. 2020 Jul 22;10(1):1-2.'},{id:"B197",body:'Zia Z, Bakhat HF, Saqib ZA, Shah GM, Fahad S, Ashraf MR, Hammad HM, Naseem W, Shahid M. Effect of water management and silicon on germination, growth, phosphorus and arsenic uptake in rice. Ecotoxicology and environmental safety. 2017 Oct 1;144:11-8.'},{id:"B198",body:'Cousins OH, Garnett TP, Rasmussen A, Mooney SJ, Smernik RJ, Brien CJ, Cavagnaro TR. Variable water cycles have a greater impact on wheat growth and soil nitrogen response than constant watering. Plant Science. 2020 Jan 1;290:110146.'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Nawab Ali",address:"nawab@aup.edu.pk",affiliation:'
Department of Agronomy, Faculty of Crop Production Sciences, The University of Agriculture Peshawar, Khyber Pakhtunkhwa, Pakistan
Department of Agronomy, Faculty of Crop Production Sciences, The University of Agriculture Peshawar, Khyber Pakhtunkhwa, Pakistan
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He obtained his Ph.D. in Chemical Engineering from the University of Alberta, Canada. In addition to teaching, Dr. Rushd is heavily involved in multiple research projects in the fields of pipeline engineering, dynamics of multiphase-flows, rheology, water treatment, and desalination. He has authored or co-authored more than thirty-five technical papers. He works as a reviewer of different reputed journals, such as Chemical Engineering Science, Engineering Applications of Computational Fluid Mechanics, Journal of Petroleum Science and Engineering, and Journal of Clean Production. 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IntechOpen’s Academic Editors and Authors have received funding for their work through many well-known funders, including: the European Commission, Bill and Melinda Gates Foundation, Wellcome Trust, Chinese Academy of Sciences, Natural Science Foundation of China (NSFC), CGIAR Consortium of International Agricultural Research Centers, National Institute of Health (NIH), National Science Foundation (NSF), National Aeronautics and Space Administration (NASA), National Institute of Standards and Technology (NIST), German Research Foundation (DFG), Research Councils United Kingdom (RCUK), Oswaldo Cruz Foundation, Austrian Science Fund (FWF), Foundation for Science and Technology (FCT), Australian Research Council (ARC).
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
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In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
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Does your institution already have a budget for covering Open Access publication costs?
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Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
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Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\n\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\n\n
\n\t
Does your institution already have a budget for covering Open Access publication costs?
\n\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\n
\n\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\n\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\n\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
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