Plasma membrane TLRs modulate inflammatory mediators.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"6147",leadTitle:null,fullTitle:"Urinary Tract Infection - The Result of the Strength of the Pathogen, or the Weakness of the Host",title:"Urinary Tract Infection",subtitle:"The Result of the Strength of the Pathogen, or the Weakness of the Host",reviewType:"peer-reviewed",abstract:"Urinary tract infection (UTI) is a problem so common and so significant in routine clinical practice that accurate diagnostics are especially important. In particular, complicated UTI is associated with an increased rate of therapy failures, as a result of possible biofilm formation on foreign elements and antibiotic resistance, as well as the increased possibility of an infection recurrence. These are the arguments for the constant search for novel diagnostic tools and techniques. These and many other vital topics regarding UTI complications, management, and treatment, in addition to antibiotic resistance and bacterial virulence traits allowing us to mitigate or avoid antibiotic action, are presented in this book.",isbn:"978-1-78923-375-9",printIsbn:"978-1-78923-374-2",pdfIsbn:"978-1-83881-304-8",doi:"10.5772/intechopen.68271",price:119,priceEur:129,priceUsd:155,slug:"urinary-tract-infection-the-result-of-the-strength-of-the-pathogen-or-the-weakness-of-the-host",numberOfPages:126,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"16821e1bfd105986c31e991510e94e70",bookSignature:"Tomas Jarzembowski, Agnieszka Daca and Maria Alicja Dębska-Ślizień",publishedDate:"June 27th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6147.jpg",numberOfDownloads:7236,numberOfWosCitations:10,numberOfCrossrefCitations:6,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:18,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:34,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 7th 2017",dateEndSecondStepPublish:"June 28th 2017",dateEndThirdStepPublish:"November 11th 2017",dateEndFourthStepPublish:"January 11th 2018",dateEndFifthStepPublish:"March 11th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"205604",title:"Dr.",name:"Tomas",middleName:null,surname:"Jarzembowski",slug:"tomas-jarzembowski",fullName:"Tomas Jarzembowski",profilePictureURL:"https://mts.intechopen.com/storage/users/205604/images/7511_n.jpg",biography:"Tomasz Jarzembowski was born in 1968 in Gdansk, Poland. He obtained his PhD degree in 2000 from the Medical University of Gdańsk (UG). After specialization in clinical microbiology in 2003, he started studying biofilm formation and antibiotic resistance at the single-cell level. In 2015, he obtained his DSc degree. His later study in cooperation with experts in nephrology and immunology results in the designation of the new diagnostic method of UTI, patented in 2017.\nHe is currently working at the Department of Microbiology, Medical University of Gdańsk (GUMed), Poland. Since many years, he is a member of steering committee of Gdańsk branch of Polish Society of Microbiologists, a member of ESCMID, a member of editorial board of international journals, and a reviewer.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"206216",title:"Dr.",name:"Agnieszka",middleName:null,surname:"Daca",slug:"agnieszka-daca",fullName:"Agnieszka Daca",profilePictureURL:"https://mts.intechopen.com/storage/users/206216/images/7512_n.jpg",biography:"Agnieszka Daca was born in 1982 in Świecie, Poland. She prepared and defended her PhD degree thesis in 2011 from the Medical University of Gdańsk and discussed the immunological changes observed in the blood of patients with SLE. After her PhD degree defense, the cooperation of Tomasz Jarzembowski and the experiments characterizing bacteria virulence traits and their interaction with immune system cells have started, resulting in the designation of diagnostic method assessing virulence potential of bacteria isolated from the urine of immunocompromised patients. These experiments have also turned her attention to innate immune system changes in patients with lupus nephritis.\nCurrently, she is working as an assistant professor at the Department of Pathology and Experimental Rheumatology, Medical University of Gdańsk. She is also a member of ESCMID.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:{id:"207724",title:"Prof.",name:"Maria Alicja",middleName:null,surname:"Dębska-Ślizień",slug:"maria-alicja-debska-slizien",fullName:"Maria Alicja Dębska-Ślizień",profilePictureURL:"https://mts.intechopen.com/storage/users/207724/images/7513_n.jpg",biography:"Professor Maria Alicja Dębska-Ślizień works in the field of nephrology and transplantology since 1985. She is the head and the chair of the Department of Nephrology, Transplantology, and Internal Medicine, GUMed, since 2015. She is a specialist in the field of internal diseases, nephrology, and clinical transplantation.\n\tHer fundamental topics of clinical and scientific interest are optimization of the treatment of patients with renal failure by means of kidney transplantation (preemptive transplantation, transplantation from living donors). She has an active participation in the European Rare Kidney Disease Reference Network (i.e., congenital glomerulopathy, TSC, ADPKD). Her other activities include optimization of hemodialysis treatment, nephro-oncology, and coordination with the Polish Renal Replacement Therapy Registry.\n\tShe is a member of the Polish Society of Nephrology, the Polish Transplantation Society (secretary-general), and the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA). Currently, she is also a member of the main board of the Polish Society of Nephrology and the Polish Transplantation Society. She is an author and coauthor of about 500 publications in domestic and foreign magazines. She is an editor and coeditor of the monograph and several guides for the sick and dozens of chapters in textbooks. She is a lecturer in Polish and international congresses.\nShe has been awarded numerous prizes for both her native university and the Polish Transplantation Society for her scientific activity.\n\nHer closest family is her husband and two children (daughter and son). Her nonprofessional interests are mountain climbing, skiing, and reading books.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1162",title:"Endourology",slug:"endourology"}],chapters:[{id:"59714",title:"Management of Complicated Urinary Tract Infection",doi:"10.5772/intechopen.74556",slug:"management-of-complicated-urinary-tract-infection",totalDownloads:1274,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"The management of complicated urinary tract infection (UTI) remains a challenge since the coexisted conditions may significantly decrease the successful rate of treatment. In this chapter, the specific conditions including indwelling catheter, urolithiasis, neurogenic bladder, vesicoureteral reflux and pregnancy are listed. In terms of each condition, the potential influence on UTI and management strategy is discussed. Not only is the current evidence reviewed but also we present our experience on management of complicated UTI.",signatures:"Ran Pang, Jianhua Deng and Xinyao Zhou",downloadPdfUrl:"/chapter/pdf-download/59714",previewPdfUrl:"/chapter/pdf-preview/59714",authors:[{id:"186524",title:"Prof.",name:"Ran",surname:"Pang",slug:"ran-pang",fullName:"Ran Pang"}],corrections:null},{id:"57462",title:"Management of Urinary Tract Infections: Problems and Possible Solutions",doi:"10.5772/intechopen.71588",slug:"management-of-urinary-tract-infections-problems-and-possible-solutions",totalDownloads:1110,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"In clinically suspected urinary tract infections (UTIs), empirical antibiotic treatment is usually started long before the laboratory results of urine culture and antibiogram are available. Although molecular diagnostic approaches are being applied to the diagnosis of many infections, UTIs are generally diagnosed by traditional culture methods. Patient care could greatly benefit from the development of a rapid, accurate, inexpensive test that could be done at patient’s bedside, allowing the practitioner to plan targeted, more effective therapy. Such a test would potentially reduce incorrect or unnecessary use of antibacterial drugs and reduce the emergence of bacterial resistance. In response to this pressing and unmet clinical need, several methods have been developed in the last few years. Among these, the new point-of-care test (POCT) for detecting UTIs named Micro Biological Survey (MBS) UTI CHECK holds promise, as it allows semi-quantitative determination of bacterial load in urine leading to a fast detection of UTIs and to evaluation of bacterial antibiotic susceptibility. This new technology operates through a colorimetric survey performed in low-cost, ready-to-use, disposable vials, in which 1 ml of urine is inoculated without any preliminary treatment and requiring neither specialized personnel nor a specialized equipment.",signatures:"Lorenza Murgia, Ottavia Stalio, Alyexandra Arienzo, Valeria\nFerrante, Valentina Cellitti, Salvatore Di Somma, Paolo Visca and\nGiovanni Antonini",downloadPdfUrl:"/chapter/pdf-download/57462",previewPdfUrl:"/chapter/pdf-preview/57462",authors:[{id:"65166",title:"Prof.",name:"Giovanni",surname:"Antonini",slug:"giovanni-antonini",fullName:"Giovanni Antonini"},{id:"187348",title:"Prof.",name:"Salvatore",surname:"Di Somma",slug:"salvatore-di-somma",fullName:"Salvatore Di Somma"},{id:"222196",title:"MSc.",name:"Lorenza",surname:"Murgia",slug:"lorenza-murgia",fullName:"Lorenza Murgia"},{id:"222197",title:"Dr.",name:"Ottavia",surname:"Stalio",slug:"ottavia-stalio",fullName:"Ottavia Stalio"},{id:"222198",title:"Dr.",name:"Alyexandra",surname:"Arienzo",slug:"alyexandra-arienzo",fullName:"Alyexandra Arienzo"},{id:"222199",title:"MSc.",name:"Valeria",surname:"Ferrante",slug:"valeria-ferrante",fullName:"Valeria Ferrante"},{id:"222200",title:"MSc.",name:"Valentina",surname:"Cellitti",slug:"valentina-cellitti",fullName:"Valentina Cellitti"},{id:"222203",title:"Prof.",name:"Paolo",surname:"Visca",slug:"paolo-visca",fullName:"Paolo Visca"}],corrections:null},{id:"58321",title:"Urinary Tract Infections in Renal Transplant Recipients",doi:"10.5772/intechopen.72430",slug:"urinary-tract-infections-in-renal-transplant-recipients",totalDownloads:1286,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Renal transplantation (RTx) is the treatment-of-choice for a significant number of patients with end-stage renal disease. Despite recent accomplishments, both surgical and medical complications still exist. Urinary tract infection (UTI) is the most common infectious complication after RTx, while asymptomatic bacteriuria is the most common manifestation of bacteriuria. UTI can impair graft function, potentially reducing graft and patient survival. The aetiology changes with time after RTx. The epidemiology of most of these infections is also changing with resistant organisms being isolated more often than in the past. Several factors increase the risk of infection in RTx patients, and the presence of multiple risk factors in the same patient is not uncommon. These include immunosuppression, urinary flow impairment (most often caused by stenosis or strictures at the vesicoureteral junction, benign prostate hypertrophy or vesicoureteral reflux), and treatment-related factors such as the use of catheters and double-J stents. Early diagnosis and effective treatment are key elements in salvaging both the allograft and the patient. This chapter reviews the definitions, epidemiology, microbiology, screening, clinical manifestations, diagnosis, impact on renal allograft function, evaluation after diagnosis, treatment, prevention including long-term prophylaxis, and the unique challenges of diagnosing and managing recurrent bacterial UTIs in a RTx care setting.",signatures:"Justyna Gołębiewska and Alicja Dębska-Ślizień",downloadPdfUrl:"/chapter/pdf-download/58321",previewPdfUrl:"/chapter/pdf-preview/58321",authors:[{id:"207724",title:"Prof.",name:"Maria Alicja",surname:"Dębska-Ślizień",slug:"maria-alicja-debska-slizien",fullName:"Maria Alicja Dębska-Ślizień"},{id:"212302",title:"Dr.",name:"Justyna",surname:"Gołębiewska",slug:"justyna-golebiewska",fullName:"Justyna Gołębiewska"}],corrections:null},{id:"61815",title:"Urinary Tract Infection in Renal Allograft Recipents",doi:"10.5772/intechopen.77171",slug:"urinary-tract-infection-in-renal-allograft-recipents",totalDownloads:948,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Renal replacement therapy in the form of renal transplantation (RT) is the treatment of choice in these patients. Various factors influence the graft survival, infections being most common. Infections account for 16% of patient deaths and 7.7% of death censored graft failure in renal transplant patients. Urinary tract infection (UTI) is the most common infectious complication accounting for 45–72% of all infections. According to few studies UTI may have a negative impact over the long term survival of renal allograft. There are multiple factors that predispose these patients to UTI. Elderly age group, female gender, increased duration of catheterization and anatomical abnormalities of the urinary tract are most common predisposing factors. E. coli is the most frequently isolated organisms from the urine of these patients. We would proceed further with two cases which presented as UTI in post-transplant period. The first patient transplanted (living donor related) for diabetes induced end stage renal disease had developed UTI 4 years post-transplant. The other patient underwent deceased donor renal transplant for adult polycystic disease related chronic kidney disease, presented 2 years post-transplant with UTI.",signatures:"Lovelesh Kumar Nigam, Aruna V. Vanikar, Rashmi D. Patel, Kamal V.\nKanodia and Kamlesh S. Suthar",downloadPdfUrl:"/chapter/pdf-download/61815",previewPdfUrl:"/chapter/pdf-preview/61815",authors:[{id:"228499",title:"Dr.",name:"Lovelesh",surname:"Nigam",slug:"lovelesh-nigam",fullName:"Lovelesh Nigam"},{id:"239124",title:"Dr.",name:"Aruna V",surname:"Vanikar",slug:"aruna-v-vanikar",fullName:"Aruna V Vanikar"},{id:"239127",title:"Dr.",name:"Rashmi",surname:"D",slug:"rashmi-d",fullName:"Rashmi D"},{id:"239128",title:"Dr.",name:"Kamal V",surname:"Kanodia",slug:"kamal-v-kanodia",fullName:"Kamal V Kanodia"},{id:"239129",title:"Dr.",name:"Kamlesh S",surname:"Suthar",slug:"kamlesh-s-suthar",fullName:"Kamlesh S Suthar"}],corrections:null},{id:"57656",title:"Uropathogenic Escherichia coli and Fimbrial Adhesins Virulome",doi:"10.5772/intechopen.71374",slug:"uropathogenic-escherichia-coli-and-fimbrial-adhesins-virulome",totalDownloads:1342,totalCrossrefCites:4,totalDimensionsCites:13,hasAltmetrics:0,abstract:"Urinary tract infections (UTIs) rank second among infectious diseases around the world, and this makes them significant. There are many microbial agents which may cause UTIs. Enterobacteriaceae family members are recognized as important UTI bacterial causative agents. Among them, uropathogenic Escherichia coli (UPEC) pathotypes are considered as the most important bacterial agents of UTIs. Today, genomics and bioinformatics explain us why UPEC strains are so considerable pathogens regarding UTIs. There is a diversity of E. coli strains involving commensal and pathogenic strains. Genomics shows that commensal strains of E. coli encompass the minimal amount of genome and genetic elements among E. coli populations, whereas the pathotypes of E. coli possess the maximal or a big portion of genomic elements. Previous studies confirm the presence of a vast range of virulence genes within the pool of E. coli pathotypes like UPEC. So, the pool of virulence genes (virulome) belonging to UPEC enables UPEC pathotypes to have huge genomes with the ability of different levels of pathogenesis. The more virulence factors, the more pathogenicity. Due to the presence of a mass of virulence factors within UPEC cellular structures, well-known fimbrial adhesins in UPEC pathotypes are discussed in this chapter.",signatures:"Payam Behzadi",downloadPdfUrl:"/chapter/pdf-download/57656",previewPdfUrl:"/chapter/pdf-preview/57656",authors:[{id:"45803",title:"Ph.D.",name:"Payam",surname:"Behzadi",slug:"payam-behzadi",fullName:"Payam Behzadi"}],corrections:null},{id:"57854",title:"Resistant Gram-Negative Urinary Tract Bacterial Infections",doi:"10.5772/intechopen.71872",slug:"resistant-gram-negative-urinary-tract-bacterial-infections",totalDownloads:1278,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Urinary tract infection (UTI) is one of the most common infections in both the community as well in hospital settings. It is mostly caused by Gram-negative bacteria (GNBs). Over the past two decades, GNBs have developed complex mechanisms of resistance against most of the potent antibiotics. This has been a global challenge which has been identified by the World Health Organization as “one of the greatest threats to human health.” This crisis is mostly attributed to the overuse and misuse of these medications, as well as lack of new drug antimicrobials by the pharmaceutical industry. This resulted in prolonged hospital stay, marked increase in the cost as well as increase in morbidity and mortality. Furthermore, it increases the risks and complications of urological procedures. In this chapter, we review the management of the most common and challenging group of resistant Gram-negative organisms, the extended-spectrum β-lactamases producing organisms (ESBL) and the carbapenem-resistant organisms (CRE/CRP). The latter group includes carbapenem-resistant Enterobacteriaceae (CRE), as well as Pseudomonas aeruginosa carbapenemases (CRP). When treating these infections, clinicians have few effective antimicrobials options. A critical step in managing these organisms is the early recognition and appropriate empiric therapy. Both showed morbidity and mortality benefits.",signatures:"Nashaat S. Hamza and Abdalla Khalil",downloadPdfUrl:"/chapter/pdf-download/57854",previewPdfUrl:"/chapter/pdf-preview/57854",authors:[{id:"212594",title:"Dr.",name:"Abdalla",surname:"Khalil",slug:"abdalla-khalil",fullName:"Abdalla Khalil"},{id:"212626",title:"Dr.",name:"Nashaat",surname:"Hamza",slug:"nashaat-hamza",fullName:"Nashaat Hamza"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"1318",title:"Urinary Tract Infections",subtitle:null,isOpenForSubmission:!1,hash:"018471a7330e239e2bfbd8b11b1111ca",slug:"urinary-tract-infections",bookSignature:"Peter Tenke",coverURL:"https://cdn.intechopen.com/books/images_new/1318.jpg",editedByType:"Edited by",editors:[{id:"62770",title:"Dr.",name:"Peter",surname:"Tenke",slug:"peter-tenke",fullName:"Peter Tenke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1448",title:"Urinary Incontinence",subtitle:null,isOpenForSubmission:!1,hash:"0c33f52801c170a775dceb2163295aa3",slug:"urinary-incontinence",bookSignature:"Ammar Alhasso",coverURL:"https://cdn.intechopen.com/books/images_new/1448.jpg",editedByType:"Edited by",editors:[{id:"124685",title:"Mr.",name:"Ammar",surname:"Alhasso",slug:"ammar-alhasso",fullName:"Ammar Alhasso"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3313",title:"Recent Advances in the Field of Urinary Tract Infections",subtitle:null,isOpenForSubmission:!1,hash:"02d234a9ee56794bfa06cce7bb94fdf1",slug:"recent-advances-in-the-field-of-urinary-tract-infections",bookSignature:"Thomas Nelius",coverURL:"https://cdn.intechopen.com/books/images_new/3313.jpg",editedByType:"Edited by",editors:[{id:"53464",title:"Prof.",name:"Thomas",surname:"Nelius",slug:"thomas-nelius",fullName:"Thomas Nelius"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1762",title:"Evolving Trends in Urology",subtitle:null,isOpenForSubmission:!1,hash:"4b9965c1c8ed456914c0a375d06d1df8",slug:"evolving-trends-in-urology",bookSignature:"Sashi S. 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Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11528",leadTitle:null,title:"Maintenance Management - Current Challenges, New Developments, and Future Directions",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tIn an industrial scenario, improper maintenance (or its lack) has several implications that can lead to unexpected breakdowns, losses at industrial production, or catastrophic consequences. In general, a fault affects only one component; however, it spreads to other components as the fault evolves. Moreover, considering cost reduction and production efficiency, developing an effective maintenance program has gained more attention, and several tools have been implemented to support and encourage best practices. In this sense, advanced data acquisition and processing methods have been developed to allow effective machine condition monitoring and early fault detection and identification, avoiding unexpected breakdowns and even catastrophic failures, especially for critical systems. Whenever possible, condition monitoring should be done non-invasively and without interrupting machine operation.
\r\n\r\n\t
\r\n\tOver the years, the concept of maintenance became more comprehensive, reducing fault occurrence and increasing industrial system availability. Besides, reliability, safety, and criticality requirements were associated with the system or equipment under analysis. Maintenance strategies or schemes can be classified as corrective (run-to-break), preventive (time-based), and predictive (condition-based maintenance). Corrective maintenance is only performed after an occurrence of a fault. Therefore, it involves unexpected breakdowns, high costs, changes in the production chain, and it could lead to catastrophic events. Preventive maintenance and interventions occur based on a scheduled maintenance plan or the equipment's mean time between failures. Although it is more effective than corrective maintenance, unexpected failure may still occur by preventing most failures. Additionally, the process cost is still high, especially the costs associated with labor, inventory, and unnecessary replacement of equipment or components.
\r\n\tOn the other hand, predictive maintenance analyses the equipment condition so that a possible fault can still be identified at an early stage. Predictive maintenance aims to identify a machine anomaly so that it does not result in a fault. Such maintenance involves advanced monitoring, processing, and signal analysis techniques, which are generally performed non-invasively and, in many cases, in real-time. In the case of machines or processes, these techniques can be developed based on vibration, temperature, acoustic emission, or electrical current signal monitoring. It should be noted that monitoring such signals or parameters to verify the operating condition is called condition monitoring. Condition monitoring aims to observe the machine's current operational condition and predict its future condition, keeping it under a systematic analysis during its remaining life. In this sense, a fault condition can be detected and identified from systematic machine condition monitoring. A diagnosis procedure can be established, whereby properly investigating the fault symptoms and prognosis.
\r\n\t
\r\n\tThis book will aim to merge all these ideas in a single volume, aggregate new maintenance experiences, apply new techniques and approaches, and report field experiences to establish new maintenance processes and management paradigms.
\r\n\t
Edema is characterized as a swelling caused by an increase of fluids in the interstitial space. Interstitial liquid deregulation causes liquid accumulation in the body with harmful consequences to tissues and organs [1, 2]. The physiologist Ernest Starling defined the interaction between the fluids forces in blood vessels. The fluid movement (FM) in the blood vessel is correlated with blood vessel wall permeability (constant Kf) and the difference between hydrostatic pressure variations (ΔP) and colloid osmotic pressure (Δπ) forces [1, 3]. The following mathematical equation (Starling’s equation) describes this interaction: FM = Kf. (ΔP- Δπ).
The liquid retention becomes harmful to tissues affecting the cellular balance and homeostasis. Several factors induce this phenomenon: hormones, plasma proteins, inflammation, infectious diseases, and disturbs in some organs [3, 4, 5]. After an injury, inflammatory mediators cause physiological reactions in the lesioned region. Some of these inflammatory molecules include interleukins (IL-1β, IL-6, and IL-18), tumor necrosis factor-alpha (TNF-α), vasodilators, arachidonic acid metabolites, nitric oxide (NO), among others [6, 7, 8]. The inflammatory agent overproduction mediates increase in vascular permeability and leukocyte recruitment, causing edema formation and hyperalgesia [2, 9].
Membrane receptors are a group of functional proteins located in the plasma and organelles membranes. These receptors are able to trigger intracellular chemical cascades [10]. Approaches in the pharmacological field investigated several plasma membrane receptors modulating inflammation [11], such as the purinergic system, TRP channels, and pattern recognition receptors (PRRs), are commonly associated with inflammatory pathways [12, 13, 14, 15, 16]. Therefore, this chapter will address the plasma membrane receptors modulation on inflammatory agents and subsequent edema formation.
Inflammation is a natural defense mechanism to Pathogen-associated molecular pattern (PAMPs) or Damage-associated molecular pattern (DAMPs) involving cells and blood vessels. In this process, local and immune cells (macrophages, neutrophils, and lymphocytes) promote the release of pro-inflammatory mediators, such as those mentioned earlier. Although the inflammatory response is a natural mechanism, this process may become harmful to tissues and organs when persistently stimulated [17, 18]. The inflammation course and edema formation are linked because edema is one of inflammation cardinal signs [2].
After a trauma or injury, intracellular components are released, modifying the inflammatory site characteristics (Figure 1). Migrant and local cells, such as mast cells and basophils, release vasoactive amines, serotonin, and histamine. These molecules initially cause increase in blood vessel permeability and vasodilation [19, 20, 21]. Thus, these vascular changes cause liquid leakage from the vascular environment. Plasma protein, such as albumin, in the extravascular medium may modulate the vascular pressures. The press alteration favors the fluid and electrolyte passage to interstitial space generating swelling [3, 22].
Inflammatory mediators are acting on vascular permeability.
Coagulation factor activation, such as the Hangeman factor, induces bradykinin and proteases synthesis stimulation. Bradykinin is a kinin involved in vascular permeability and other vascular mechanisms [23, 24, 25]. Additionally, the complement system fragments exhibit a crucial role in the immunity and vascular processes. The anaphylatoxins, such as C3a, C4a, and C5a, act on leukocyte recruitment and also in bradykinin signaling [23, 26, 27, 28, 29].
The pro-inflammatory cytokines participate in pain mechanisms and also promotes increase in vascular permeability [23]. Stamacovic [30] described cytokines participating in the central nervous system inflammation and Blood–brain barrier permeability. The increase in IL-1β, IL-6, and TNF-α may cooperate for brain edema emergence. Martin et al. [31] showed vascular increase induced by IL-1 and IFN-y in Wistar rats. IL-1β is very approached in a mechanism involving nociception and sensibility to pain, as well as bradykinin [32, 33]. Furthermore, increase of IL-1β and TNF-α induct arachidonic acid metabolites [34]. Arachidonic acid metabolites like prostaglandins, leukotrienes, prostacyclin, and thromboxane also mediate vascular changes [35]. Prostaglandins is directly involved in the modulation of pain mechanisms [9, 36].
IL-18 is another IL-1 family member involved in pain mechanisms. The IL-1β and IL-18 synthesis possess similarities in their signaling [37]. Pilat and colleagues’ study involving the IL-18 inhibition [38] showed nociception reduction in a neuropathic pain model. Besides, IL-18 is also notorious as the IFN-y-inducing factor [37, 39].
Additionally, inflammatory mediators modulate inflammatory diseases, and some data confirms this actuation in organ pathophysiology such as lung, liver, heart, and others [40, 41, 42, 43]. Thus, vital organ disturbs promote vascular fluids imbalance. Additional data about cytokines modulation at vascular mechanisms can be found in the following works [23, 44, 45].
Scientific advances provide new discoveries about plasma membrane receptors function and identity. Molecules impermeable to the membrane can selectivity cross to the intracellular environment through these receptors. Many receptors characteristics are investigated in the physicochemical field, including biophysical properties and structure. Membrane receptors generally have three classifications: receptors coupled to enzymes such as tyrosine kinase (RTKs), G protein-coupled receptors (GPCRs), and ion channels [46]. Interestingly, there is a group of membrane proteins that are widely addressed in scientific research for modulating inflammatory mediators release and search for new anti-inflammatory drugs. Based on this, the following topics exhibit some of studied plasma membrane receptors related to the inflammatory response.
The host defense against infections and tissue damage is a complex mechanism. In this process, the cells must recognize PAMPs and DAMPs to initiate a specific intracellular response against infectious agents, such as viruses and bacteria or dangerous signs, such as burn injuries [47].
The Toll-Like Receptors (TLRs) are a group of membrane proteins involved in inflammation and immunity. They act on PRRs expressed in macrophages, neutrophils, and dendritic cells [47, 48]. TLRs compose the interleukin 1 receptors superfamily (IL-1Rs) with slight structural differences. Ten TLRs subtypes were described in humans (TLR1–10), although other species may exhibit variations.
TLRs are located in different compartments in the cell. For instance, the subtypes 1, 2, 4, 5, and 6 are located at the cell plasma membrane, whereas subtypes 3, 7, 8, 9, and 10 are in the intracellular compartment, located in endosomes. [RF1] TLR2 and TLR4 are the best-studied receptors of this family [49, 50].
TLRs, when activated, are essential for the host response to harmful agents, since these receptors modulate the inflammatory mediators release. The factor nuclear kappa β (NF-kβ) and mitogen-activated protein kinase (MAPKs) are classical pathways activated by Toll-Like Receptors (Figure 2) [48]. When stimulated by a ligand, such as lipopolysaccharides (LPS), TLRs transduces the signal through adaptor molecules in the intracellular environment. Myeloid differentiation primary response 88 (MyD88) is an adaptor molecule of the interleukin- 1 receptor-associated kinases (IRKs) signaling with subsequent TNF receptor-associated factor 6 (TRAF6) activation. TRAF6 activates the growth factor β-activated kinase 1 (TAK1), which triggers an enzymatic complex associated with NF-kβ translocation to the cell nucleus. TAK1 signaling also activates the MAPKs pathway with activator protein 1 (AP-1) nuclear factor translocation. This pathway leads to various pro-inflammatory mediators transcription, such as cytokines (IL-1 family, IL-6, TNF-α),
Plasma membrane TLR signaling pathway. TLR receptor activation triggers AP-1 and NF-kβ transcription factors.
TLR activation may exhibit a crucial role in edema formation through inflammatory mediator production (Table 1). In a recent paper, Okada and colleagues [55] described brain edema reduction in a subarachnoid hemorrhage model (SAH) mouse after treatment with TAK-242, a TLR4 receptor inhibitor. The molecular mechanism by which this occur was not evaluated. However, the pathophysiology development of brain edema shows association with TLR4 function. In liver diseases, such as acute liver failure, astrocyte swelling is a notable characteristic that promotes brain edema formation. Interestingly, NF-kβ and MAPKs-induced cytokine release are crucial mechanisms for astrocyte swelling development [56, 57]. Jayakumar et al. [58] have demonstrated LPS and cytokines-induced astrocyte swelling increase. These data suggest TLR4 may be a target in the brain edema pathophysiology.Table 1 represent more data about TLR receptors in the inflammatory context.
Receptor | Ligand | Involvement in inflammation and edema | References |
---|---|---|---|
TLR1 | Tri-acyl lipopeptides | TLR1 works together with TLR2 as a heterodimer. This subtype also mediates the intracellular cytokines transcription | [47, 52] |
TLR2 | Peptidoglycan | TLR2 signaling intracellular transcription of inflammatory mediators Cytokine gene expression such as IL-1β, TNF-α, and IL-6 decrease in TLR2 Knock out mice in vascular injury model TLR2 plays a role in mast cells degranulation and cytokine release stimulated by peptidoglycan | [47, 53, 54] |
TLR4 | LPS | TLR4 activation leads to inflammatory mediators transcription involved in pain and edema, such as LPS induces astrocyte swelling and brain edema pathogenesis. TLR4 also increases TNF-α and IL-1β in LPS-induced mast cells | [47, 50, 54, 55, 56, 57, 58] |
TLR5 | Flagellin | TLR5 can be activated by high mobility group box 1 (HMGB1), a protein that plays a role in inflammation. The HMGB1 action on TLR5 induced the pro-inflammatory mediators intracellular signaling. TLR5 also plays a protective role in intestinal cells. | [47, 52, 59] |
TLR6 | Di-acyl lipopeptides | TLR6 functions are interacting with TLR2 and TLR4 as a heterodimer. | [47, 52] |
Plasma membrane TLRs modulate inflammatory mediators.
Histamine constitutes an essential molecule in cell biology, edema pathophysiology, and the inflammatory process. The histamine synthesis occurs with the amino acid L-histidine decarboxylation through the histidine decarboxylase enzyme (HDC). Other inflammatory mediators can lead to increase HDC activity, such as IL-1 cytokines [60]. Histamine synthesis occurs in different body cells, although this production primordially occurs in mast cells and basophils [61]. In these cells, histamine is stored in cytoplasmatic granules and released according to the stimulus presented. Histamine interacts with GPCRs membrane receptors classified as histamine receptors (HRs) and divided into four subtypes: HR1, HR2, HR3, and HR4 (Table 2) [61].
Receptor | Ligand | Involvement in inflammation and edema | References |
---|---|---|---|
HR1 | Histamine | HR1 is involved in allergic response HR1 influences MPAK signaling and modulates Th1 response. | [61, 62, 63] |
HR2 | Histamine | HR2 modulates Th2 response HR2 regulates IL-10 and antinociceptive activity | [61, 62, 64] |
HR3 | Histamine | HR3 exhibits an essential role in neuronal inflammation and neuropathic pain. HR3 inhibition has been shown to be beneficial in inflammation and edema stimulated by formalin | [61, 65] |
HR4 | Histamine | HR4 also participates in MAPK signaling. HR4 inhibition shows to reduce neutrophil infiltration, edema, and hyperalgesia in acute inflammation | [60, 63, 66, 67] |
Histamine receptors.
The histamine action is remarkable in the vascular modulation mechanism, including vascular permeability increase. HRs actuate as a second messenger, leading to intracellular signal and cytokine synthesis [68]. A study by Delaunois and co-authors [69] showed a protective HR3 agonist role in pulmonary edema stimulated by inflammation-promoting molecules. In addition, HR3 stimulation appears to play a significant role in perfusion in post-burn tissues [70]. HRs also participate in the mechanisms related to antinociception [61].
Among HRs, HR4 has become a new antihistamines studies target. The HR4 activation triggers MAPK, which leads to pro-inflammatory mediators synthesis [60]. Coruzzi and collaborates [66] showed promising results in inhibiting paw edema by HR4 in acute inflammation. After carrageenan-induced edema, two selective HR4 inhibitors, JNJ7777120, and VUF6002, respectively, were evaluated. Inhibition by JNJ7777120 after two hours of carrageenan induction has shown notable values compared to VUF6002. Another study using JNJ7777120 described the anti-nociceptive role in a pain inflammation model through HR4 antagonism. Additionally, HR4 inhibition decreases neutrophilic influx to stimulated area pretreated with JNJ7777120 [67]. These findings suggest HR4 with a crucial role in edema and pain mechanism.
Diseases involving the psychiatric area have been widely addressed in scientific research, such as depression. [RF2] Factors involving mood and mental disorders, include serotonin, a critical functional amine in this disease. Interestingly, serotonin regulates inflammatory signaling, playing a role in vascular permeability. Therefore, serotonin becomes a multifunctional molecule modulating many body processes [71, 72, 73].
5-hydroxytryptamine (5-HT), serotonin is synthesized from the amino acid tryptophan. The enzymes tryptophan hydroxylase and tryptophan decarboxylase are responsible for 5-HT production. Serotonin may be found in various body tissues, such as enterochromaffin, platelets, brain, and lung [71]. 5-HT interacts with membrane receptors (5-HT receptors), divided into seven families (5-HT1–7), where these receptors are GPCRs, except for 5HT3, which belongs to ion channels. These receptors possess fourteen subtypes: 5-HT1 (A, B, D, E, and F), 5-HT2 (A, B, and C), 5-HT3 (A, B), 5-HT4, 5-HT5 (A), 5-HT6, and 5-HT7 [74, 75].
The 5-HT role in other systems has been studied over the years. During inflammation, 5-HT plays an essential role in vascular permeability, as well as histamine, in addition to participating in pro-inflammatory mediator production [72]. In this context, serotonergic receptor subtypes act on inflammation process biochemistry. 5-HT7 is influential in peripheral inflammatory modulation, according to Albayrak and co-authors [76]. The 5-HT7 participates in the nociception mechanism with other 5-HT receptors, such as 5-HT1 and 5-HT2 [77, 78]. The 5-HT2 subtype (A) subtype also modulates the inflammatory process. Nishiyama studies [79] have demonstrated a role for 5-HT2A in cytokines synthesis during an inflammation model induced by endotoxin shock. The 5-HT2A inhibition reduced TNF-α, IL-1β, IL-8, and IL-6 levels. Interestingly, IL-10 levels (cytokine with anti-inflammatory function) increased due to 5-HT2A inhibition. Additionally, 5-HT2A shows to play a function in body temperature control [80]. These data demonstrate a relevant role for 5-HT2A receptors in inflammation pathophysiology (Table 3).
Receptor | Ligand | Involvement in inflammation and edema | References |
---|---|---|---|
5-HT1 | Serotonin | 5-HT1 receptors stimulation induces a role in neurogenic inflammation Intrathecal 5-HT1A, 5-HT1B, and 5-HT1D receptor agonists administration decreased the peripheral inflammatory edema induced by carrageenan. | [81, 82] |
5-HT2 | Serotonin | 5-HT2A subtype inhibition increased IL-10 in inflammation induced by shock with endotoxins. 5-HT2A receptor activation decrease TNF-α-induced inflammation 5-HT2A regulates the body temperature 5-HT2B subtype shows the immunomodulatory function in dendritic cells | [79, 80, 83, 84] |
5-HT3 | Serotonin | 5-HT3 inhibition decreased inflammatory cytokines and neutrophilic action in a colitis model 5-HT3 decreases pain in carrageenan-induced inflammation | [72, 85, 86] |
5-HT4 | Serotonin | Spinal 5-HT4 receptor antagonism decreased hyperalgesia effects 5-HT4 induced IL-1β and IL-8 release in mature dendritic cells. | [72, 87, 88] |
5-HT5 | Serotonin | Intrathecal administration appears to show an anti-nociceptive role for spinal 5-HT5A receptors | [89, 90] |
5-HT6 | Serotonin | Like 5-HT4, 5-HT6 receptor antagonism is also beneficial in hyperalgesia | [87, 91] |
5-HT7 | Serotonin | 5-HT7 receptor stimulation has an anti-inflammatory role in the periphery carrageenan-induced inflammation 5-HT7 agonist decreased Like 5-HT4, 5-HT7 activation also induces IL-1β and IL-8 secretion in dendritic cells. | [76, 88, 92] |
Serotonin receptors.
The purinergic system is a group of transmembrane proteins activated by extracellular purine ligands, such as adenosine and other derivatives, adenosine triphosphate and diphosphate (ATP and ADP). Interestingly, when the ATP molecule is found in elevated concentration in the extracellular environment (eATP), this nucleotide may become a DAMP and regulates the inflammatory process. Purinergic receptors are formed by two groups (P1 and P2) differing in structure and activation ligands on mammalian cells [93, 94].
The adenosine molecule activates the P1 group and possesses four subtypes (A1, A2a, A2b, and A3). The P1 group comprises GPCRs receptors, and the P2 group is extensive and divided into two families, P2X and P2Y. The P2X receptors form ATP-activated ion channel receptors with seven subtypes (P2X1–7). P2Y receptors are GPCRs, like the P1 group. Interestingly, ATP and their derivatives activate the P2Y receptors, although, pyrimidine molecules, such as uridine diphosphate (UDP and UDP-glucose), also modulate some subtypes activation. This family consists in eight subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P213, and P2Y14) in mammals. The purinergic receptors participate in inflammation and immune response and are expressed in several tissues [14].
In the purinergic group, the receptor of great scientific notoriety is the P2X7 receptor (P2X7R), addressed in several mechanisms, such as cell death and inflammatory cytokines release [14]. P2X7R have the capacity to increase membrane permeability for large solutes after prolonged ATP activation. The prolonged P2X7R stimulation induces a pore opening that allows the molecules of up to 900 Da. This mechanism highlights the P2X7R as a pore-forming protein, similar to other membrane receptors, such as some TRP channels [95].
However, a striking P2X7R feature is the participation in the maturation of IL-1 cytokine family (IL-1β and IL-18) release. The IL-1β and IL-18 production and maturation require two signaling mechanisms, one mediated by pattern recognition receptors (via TLRs family activation) and a second by a danger signal, such as eATP. The activation of TLRs induces nuclear transcription through NF-kβ of the immature forms of these cytokines (ProIL-1β and ProIL-18), concluding the first stage.The eATP activates the P2X7R, beginning the cascade signaling that compose the Nod-like receptor protein-3 (NLRP3) inflammasome complex with subsequent IL-1β and IL-18 maturation and release [48, 96]. The following figure illustrates this mechanism more clearly (Figure 3).
IL-1β and IL-18 synthesis after P2X7R activation. The first signaling occurs with the ProIL-1β and ProIL-18 transcription after TLRs receptor activation (TLR4). The second signal arrives with the eATP stimulating the P2X7R. The receptor activation induces the NLRP3 inflammasome complex, and finally, IL-1β and IL-18 conversion for mature form.
The IL-1β inhibition in inflammation and pain has been addressed in several inflammation studies. Experiments in vivo using P2X7R antagonist have demonstrated improvements in the swelling caused by inflammation in a model of paw edema [97, 98]. The pain sensibility mechanism is linked to vascular permeability, causing edema [2]. Furthermore, P2X7R inhibition reduces pro-inflammatory cytokines, such as IL-1β and other mediators, since the P2X7R is responsible for these mechanisms [96]. Additionally, the P2X4 receptor has participated in IL-1β and IL-18 signaling based on Chen et al. [99]. Further, other purinergic receptors data in edema and inflammation have already been approached in the literature (Table 4).
Receptor | Ligand | Involvement in inflammation and edema | References |
---|---|---|---|
A1R | Adenosine | A1R receptor stimulation increased leukocyte recruitment and edema formation in acute pancreatitis disease. A1R participates in pulmonary inflammation and influence vascular permeability through inflammatory cytokines release in monocytes and neutrophils | [100, 101] |
A2R | Adenosine | A2aR decreases cytokine synthesis (IFN-γ, IL-4, and IL-2) in lymphocytes and influence platelet aggregation. A2bR mediates several pro-inflammatory cytokines (IL-1β, TNF-α) synthesis In contrast, A2bR also exerts an anti-inflammatory action, as observed for IL-10 release in macrophages. | [101] |
A3R | Adenosine | A3R stimulation induces histamine and serotonin release and inflammation in rat paw. A3R seems to mediate benefits in control hyperalgesia | [102, 103] |
P2X4R | ATP | P2X4 induces IL-1β and IL-18 cytokines maturation through NRLP3 inflammasome P2X4R is involved in prostaglandin E2 release and pain | [14, 99, 104] |
P2X7R | ATP | P2X7R activation produces cytokines, such as IL-1β and IL-18 maturation through NRLP3 inflammasome and TNF-α P2X7R regulates prostaglandin E2 release P2X7R antagonism reversed edema and hyperalgesia P2X7R stimulation leads to vascular bed inflammation through IL-1β release | [14, 96, 97, 98, 105, 106] |
P2YR | ATP/UDP/UDP-glucose | P2Y1R, P2Y2R, and P2Y6R are associated with leukocyte chemotaxis. P2Y1R, together with P2Y12R, have a function in platelet aggregation Like P2X7R, P2Y6R activation in endothelial cells promotes vascular inflammation and fluids leakage. | [107, 108, 109] |
Purinergic receptors.
The physiological mechanisms of pain and temperature stimuli indicate the transient receptor potential (TRP) as a target in this regard [110]. The TRP channels superfamily is constituted of transmembrane cationic ionotropic receptors. In mammals, six subfamilies classify the TRP channels into two groups. The first group: TRPC (canonical), TRPV (vanilloid), TRPA (ankyrin), and TRPM (melastatin). The second group is composed of TRPML (mucolipin) and TRPP (polycystic). This chapter will discuss the most addressed subfamilies in the scientific literature: TRPV, TRPM, and TRPA based on their involvement in inflammation and pain. These subfamilies are classified in TRPV1–6, TRPM1–8, and TRPA1 receptors [111, 112].
TRPV1 is the most studied TRP channel because of its noxious heat and inflammation perception. TRPV1 is a pore-forming protein, like P2X7R and other TRPs, such as TRPV2–4, TRPA1, and TRPM8 (Table 5). All these channels promote pore opening, and molecules flux up to 900 Da [117]. Capsaicin is one TRPV1 receptor agonist and plays a critical role in nociception pathogenesis [124].
Receptor | Ligand | Involvement in inflammation and edema | References |
---|---|---|---|
TRPV1 | Capsaicin/Protons/Heat sensor | TRPV1 channel is involved in the release of the neuropeptide like substance P in sensory fibers Capsaicin administration showed painful effects in mouse paws, which were diminished by TRPV1 inhibitors TRPV1 increased intracellular Ca+2 concentration inducing the cytokines transcription such as IL-1β and TNF-α through the NF-kβ pathway In the endotoxin-induced lung injury model, TRPV1 reduced the pro-inflammatory cytokines levels | [113, 114, 115, 116] |
TRPV4 | 4α-Phorbol 12,13-didecanoate/Osmotic sensor | TRPV4 activation in vascular endothelial cells caused an increase in vascular permeability. TRPV4 is sensitive to hypo-osmotic stress in chondrocytes | [117, 118, 119] |
TRPA1 | Allyl Isothiocyanate (AITC)/Cold sensor | Like TRPV1 channels, TRPA1 acts on neuropeptides molecules regulation and nociception. TRPA1 induced edema in an acute inflammation model using AITC TRPA1 stimulation by AITC has been shown to influence the | [113, 116, 120] |
TRPM8 | Menthol/Eucalyptol/Cold sensor | TRPM8 channels inhibited edema and inflammation by decreasing pro-inflammatory cytokines (TNF-α and IL-1β) Menthol produced analgesic effects on inflammatory pain through the TRPM8 channel | [16, 121, 122, 123] |
Transient receptors potential.
The TRPV1 receptor (heat sensor) together with TRPA1 (cold sensor) can modulate the neuropeptide molecules release like substance P. This molecule encompasses many biochemical processes involved in inflammation, such as histamine and serotonin released by mast cells, which leads to increased vascular permeability and hyperalgesia [113]. Hoffmeister and co-authors [125] described a reversion in edema and pain caused by monosodium urate crystals after TRPV1 inhibition. These findings may be associated with the mechanism mentioned above with TRPV1 participation. Additionally, TRPV1 and TRPA1 receptor inhibition decreased pro-inflammatory cytokines levels, such as TNF-α, IL-1β, and IL-6 in an endotoxin-induced lung injury model [114]. Interestingly, Li et al. [115] demonstrated TRPV1 activation associated with NF-kβ phosphorylation through the intracellular Ca2+ influx. Based on this data, TRPV1 receptors play a critical role in the modulation of the pro-inflammatory cytokines.
Another notorious receptor involved in the low temperatures detection in conjunction with TRPA1 is the TRPM8 receptor. TRPM8 exhibits an essential role in neuropathic pain and anti-inflammatory effects [111]. TRPM8 is the most studied receptor in cold physiology. TRPM8 activation reverses the hyperalgesia caused by TRPV1 and TRPA1 stimuli [16]. Experiments using eucalyptol, a TRPM8 agonist, show promising results in reducing pro-inflammatory cytokines in paw edema [121]. Studies with cold therapy can have analgesic and anti-edema effects [122]. These findings make the TRPM8 receptor a target in this context.
A large quantity of plasma membrane receptors modulates the inflammation and immune response processes. In this work, we discuss the membrane receptor groups as therapeutic targets for inflammation and edema processes. The connection between the receptor systems is vast, and the response can vary according to the stimulus. Thus, other receptors can fit this context, such as cholinergic, dopaminergic, and adrenergic receptors. These are other examples of membrane receptors that can also be addressed in this context [126, 127, 128].
Additionally, bradykinin also promotes a role in vascular permeability. Bradykinin receptors divide into B1, and B2 (GPCRs) play a crucial role in edema pathogenesis [129, 130]. Further, cytokines receptors are also involved in inflammation mechanisms, such as IL-1 family and TNF-α receptor [131].
The inflammatory process (edema, cell migration, pain, and other) treatment mainly uses non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. NSAIDs inhibit eicosanoid metabolites produced for the COX pathway, whereas corticosteroids are based on hormones released by the endocrine glands [132]. On the other hand, the more serious problem with these drugs is their prolonged use in treatments, presenting toxicity to organs. Based on this, the membrane receptors discussed in this chapter are promisor candidates for inflammation treatment. In addition, some classes possess agonists and antagonists commercially available among these receptors, such as 5-HT receptors and HRs.
Interestingly, clinical trials have already been realized and described in the literature concerning other membrane receptor types for reducing inflammatory diseases and their symptoms (Table 6). Therefore, we highlight four receptors discussed in this chapter with great potential in modulating the inflammation (TLR4, HR4, P2X7R, and TRPV1).
Receptor | Compound | Disease | Clinical study | Results | References |
---|---|---|---|---|---|
TLR4 | NI-0101 | Rheumatoid arthritis (RA) | Phase II | Insufficient therapeutic effects | [133] |
HR4 | JNJ-39758979 | Asthma | Phase IIa | Potential in patients with eosinophilic inflammation | [134] |
Toreforant | RA | Phase IIa and IIb | No improvement in Phase IIb study | [135] | |
Eosinophilic asthma | Phase IIa | No significant effects on the applied dose | [136] | ||
ZPL-3893787 | Atopic dermatites (DA) | Phase IIa | Improvement in skin lesions | [137] | |
P2X7R | AZD9056 | RA | Phase IIa and IIb | Insufficient therapeutic effects | [138] |
Crohn’s disease (DC) | Phase IIa | Good effects in improving symptoms in moderate and severe DC | [139] | ||
CE-224.535 | RA | Phase IIa | Insufficient therapeutic effects | [140] | |
TRPV1 | JNJ-38893777 | Not available | Phase I | Tolerable and safe for future investigations | [141] |
PAC-14028 | DA | Phase IIb | Effectiveness for the treatment of mild and moderate AD | [142] |
Receptor antagonist compounds highlighted in clinical trials for inflammatory diseases.
The inflammation field encompasses broad aspects, such as chemical mediators (cytokines, vasoactive amines, and lipid mediators), pain, and edema. The plasma membrane receptors influence on the inflammatory process is widely explored in scientific research. Concerning data discussed in this chapter, membrane receptors are promising and directly involved in the inflammatory mediators modulation in the edema and hyperalgesia pathophysiology. Thus, these new data open a horizon in the search for new pharmacological targets with anti-edema and analgesic effects in the therapeutic perspective of the inflammatory process.
We grateful the Coordination of Superior Level Staff Improvement (CAPES) – Finance Code 001, Oswaldo Cruz Institute (IOC), and Post-graduation of Sciences and Biotechnology PPBI), and Federal Fluminense University (UFF). This work was supported by CNPq (National Council of Research of Brazil) (RXF holds a grant with Fellowship Process Number 308755/2018-9), CP holds a grant from the Brazilian agency CNPq. FAPERJ (Research Support Foundation of the State of Rio de Janeiro) (JCNE (Young Scientist from Our State) with Fellowship process number E-26/203.246/2017) and Emergent Group of Research from Rio de Janeiro (E-26/211.025/2019).
The authors declare no conflict of interest.
Place any other declarations, such as “Notes”, “Thanks”, etc. in before the References section. Assign the appropriate heading.
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globalization, global competition, workforce diversity, and continual innovations. Complex adaptive systems (CAS) are organizations that are a composite of the interconnected whole. Teams must manage and operate in emerging ecosystems, understand factors that lead to team effectiveness when managing and facilitating teams and team conflict, and understand the development of conflict models. This chapter provides an overview of teams, CAS, conflict stages, and conflict models. This chapter presents adaptive leadership as one leadership style that offers organizations with the capabilities of reacting to changing environments quickly. Adaptive leadership offers a prescriptive approach for managers and leaders to follow when dealing with organizational conflict while operating in today’s complex and global environment.",book:{id:"6305",slug:"organizational-conflict",title:"Organizational Conflict",fullTitle:"Organizational Conflict"},signatures:"John R. 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SMEs provide for acceleration and economic growth of the country and its regions. Investment in human capital in SMEs, (meaning investment into intangible assets of the company), it is one of the ways to support this sector. In the same manner as SMEs are considered to be a driving force of the economy, human resources can be seen as its driving force, the source of success, competitiveness and added value of businesses. Human capital is one of the most valuable components of any business and that is why investment in human resources becomes a necessary step ensuring that a business prospers in a changing market environment. Current trends also point to the growing importance of investment in human capital. The future will certainly belong to those companies which pay most attention to effective management of human resources, which, in terms of time factor is an important prerequisite for growth and competitiveness of a company.",book:{id:"5826",slug:"issues-of-human-resource-management",title:"Issues of Human Resource Management",fullTitle:"Issues of Human Resource Management"},signatures:"Josef Drábek, Silvia Lorincová and Jana Javorčíková",authors:[{id:"199928",title:"Dr.",name:"Silvia",middleName:null,surname:"Lorincová",slug:"silvia-lorincova",fullName:"Silvia Lorincová"},{id:"199933",title:"Mr.",name:"Josef",middleName:null,surname:"Drábek",slug:"josef-drabek",fullName:"Josef Drábek"},{id:"199934",title:"Mrs.",name:"Jana",middleName:null,surname:"Javorčíková",slug:"jana-javorcikova",fullName:"Jana Javorčíková"}]},{id:"54634",doi:"10.5772/67868",title:"Use of Psychological Examinations of Employees and Job Applicants in Personnel Management",slug:"use-of-psychological-examinations-of-employees-and-job-applicants-in-personnel-management",totalDownloads:1628,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"This paper deals with psychological and diagnostic examination of the personality of employees and candidates for work, an unexplored subject in the field of labour law and human resource (HR) management in Slovakia. Based on legal analysis of national and international laws and regulations as well as medical knowledge in clinical and occupational psychology, the authors surveyed employers in various industry sectors to test several hypotheses. The results of this study and other empirical data are the foundation for conclusions and the legal basis for drafting a proposal to amend the current legal framework in Slovakia as well as in‐house company procedures known as ‘best‐practices’.",book:{id:"5826",slug:"issues-of-human-resource-management",title:"Issues of Human Resource Management",fullTitle:"Issues of Human Resource Management"},signatures:"Andrea Olšovská and Marek Švec",authors:[{id:"198386",title:"Associate Prof.",name:"Andrea",middleName:null,surname:"Olšovská",slug:"andrea-olsovska",fullName:"Andrea Olšovská"},{id:"198850",title:"Dr.",name:"Marek",middleName:null,surname:"Švec",slug:"marek-svec",fullName:"Marek Švec"}]},{id:"54880",doi:"10.5772/intechopen.68433",title:"Innovative Work Behavior: To What Extent and How Can HRM Practices Contribute to Higher Levels of Innovation Within SMEs?",slug:"innovative-work-behavior-to-what-extent-and-how-can-hrm-practices-contribute-to-higher-levels-of-inn",totalDownloads:2096,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"In this chapter, the influence of HR practices and more specifically the Ned Herrmanns development tool HBDI on the development of innovative work behavior (IWB) is described. Innovative work behavior today is important for organizations to stay in a competitive position. Also for small and medium-sized enterprises (SMEs), like the case study in this chapter, innovation is essential to keep the SME’s competitive advantage. As people are the most important resource in service companies, and they can contribute to innovation via their motivation and skills, the role of human resource management is important. In this book chapter, we analyze the positive influence of various HR practices on IWB. One of these HR practices is the HBDI tool, a specifically designed questionnaire which gives people insight into their problem-solving styles. The outcomes of the study in this chapter show that both HR practices and also the HBDI tool have a positive influence on developing innovative work behavior and on innovation performance.",book:{id:"5826",slug:"issues-of-human-resource-management",title:"Issues of Human Resource Management",fullTitle:"Issues of Human Resource Management"},signatures:"Joost Bücker and Eveline van der Horst",authors:[{id:"199058",title:"Dr.",name:"Joost",middleName:null,surname:"Bücker",slug:"joost-bucker",fullName:"Joost Bücker"},{id:"202237",title:"MSc.",name:"Eveline",middleName:null,surname:"Van Der Horst",slug:"eveline-van-der-horst",fullName:"Eveline Van Der Horst"}]},{id:"58609",doi:"10.5772/intechopen.73092",title:"Organizational Trust as a Conflict Management Tool in Contemporary Work Organizations",slug:"organizational-trust-as-a-conflict-management-tool-in-contemporary-work-organizations",totalDownloads:1457,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Conflict between management and employees or among employees is an irresistible phenomenon in contemporary work organizations. Evidences gathered from past and present studies revealed that a lot of conflict situations have occurred in work organizations which have significantly impacted organizational performance and its survival in recent times. Consequently, several conventional strategies and techniques have been deployed to constructively manage conflict situation in work organization however, realities show that managing conflict in work organizations remain a challenge to managers in today’s world of work. This is partly due to the fact that conflict arises from different sources; hence it is inimical to subscribes to the idea of one-size-fit-all approach to management of conflict. Based on this momentum, this chapter examines organizational trust as a conflict management tool in contemporary work organizations using an explanatory design and a basic review of literature. The chapter therefore explains the concept of organizational conflict vis-a vis organizational trust within the context of work organization. It also discusses factors causing conflict situation. It examines the importance of trust and factors responsible for the development of trust in organizations. The chapter further examines some theories of trust and also develops a framework for dealing with conflict in work organization.",book:{id:"6305",slug:"organizational-conflict",title:"Organizational Conflict",fullTitle:"Organizational Conflict"},signatures:"Oludele Mayowa Solaja",authors:[{id:"211557",title:"Mr.",name:"Oludele",middleName:"Mayowa",surname:"Solaja",slug:"oludele-solaja",fullName:"Oludele Solaja"}]}],mostDownloadedChaptersLast30Days:[{id:"55499",title:"Human Resources Management in Nonprofit Organizations: A Case Study of Istanbul Foundation for Culture and Arts",slug:"human-resources-management-in-nonprofit-organizations-a-case-study-of-istanbul-foundation-for-cultur",totalDownloads:2198,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The aim of this study is to investigate the efficiency and importance of human resources management in nonprofit organizations. The understanding was included to the literature as personnel management at the beginning of the twentieth century and it turned into an approach as human resources management in the 1980s. It could be observed that many organizations, which deem the human as the most critical stakeholder, adopt a traditional way of personnel management in operating human resources. The employees play a key role in the success of an organization. For this reason, subjects such as recruitment, training, development, career management, performance appraisal, occupational health, and safety are the fundamental functions of human resources management. The study examines to what extent these roles are evaluated through a case study. The subject matter of the study is the most powerful culture and art foundation in Turkey. Compared to many other nonprofit organizations, the foundation actively performs a variety of services within a year worldwide. The fact that the total number of employees might rise up to 800, including the field personnel, indicates the need of a good functioning human resources management. The human resources practices of the foundation are examined and evaluated within that scope.",book:{id:"5826",slug:"issues-of-human-resource-management",title:"Issues of Human Resource Management",fullTitle:"Issues of Human Resource Management"},signatures:"Beste Gökçe Parsehyan",authors:[{id:"189113",title:"Dr.",name:"Beste",middleName:null,surname:"Gokce Parsehyan",slug:"beste-gokce-parsehyan",fullName:"Beste Gokce Parsehyan"}]},{id:"55186",title:"Labor Relations: Contemporary Issues in Human Resource Management",slug:"labor-relations-contemporary-issues-in-human-resource-management",totalDownloads:2986,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"In this chapter, we examine the labor relations through the role of trade unions, collective bargaining, wages and benefits across the European Union. We conclude that labor relations have a direct influence on the labor market, designing the lines for taking decisions in organizations, but also, by governments. Our argumentation explains the relationship between employers and employees through legal rights (established by the law), negotiation process, collective bargaining, ‘actors’ in this process, wage and benefits, social and security protection.",book:{id:"5826",slug:"issues-of-human-resource-management",title:"Issues of Human Resource Management",fullTitle:"Issues of Human Resource Management"},signatures:"Ana‐Maria Bercu and Ana Iolanda Vodă",authors:[{id:"198390",title:"Dr.",name:"Ana-Maria",middleName:null,surname:"Bercu",slug:"ana-maria-bercu",fullName:"Ana-Maria Bercu"},{id:"206016",title:"Dr.",name:"Ana Iolanda",middleName:null,surname:"Voda",slug:"ana-iolanda-voda",fullName:"Ana Iolanda Voda"}]},{id:"54634",title:"Use of Psychological Examinations of Employees and Job Applicants in Personnel Management",slug:"use-of-psychological-examinations-of-employees-and-job-applicants-in-personnel-management",totalDownloads:1628,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"This paper deals with psychological and diagnostic examination of the personality of employees and candidates for work, an unexplored subject in the field of labour law and human resource (HR) management in Slovakia. Based on legal analysis of national and international laws and regulations as well as medical knowledge in clinical and occupational psychology, the authors surveyed employers in various industry sectors to test several hypotheses. 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The object of this chapter is the corporate culture in Slovak enterprises and the possibilities of its change towards the raising level of human resources development. Based on the analysis of corporate culture in selected enterprises, the aim of the chapter is to propose methodology for management of change of corporate culture supporting the development of human resources in enterprises. The sociological interview identifies the predominant type of corporate culture in Slovak medium and large enterprises in years 2014 – 2016. The examination is based on the assumption that there are significant differences between preferred values of corporate culture in local and global enterprises. It also identifies the need to change the corporate culture in enterprises and their awareness of corporate culture change management towards human resources development. The results of the survey verify Slovak managers’ interest on human resources development and the formation of strong corporate culture. The results are the basis for the formulation of proposals and recommendations resulting in the methodology for management of change of corporate culture supporting the development of human resources in enterprises.",book:{id:"5826",slug:"issues-of-human-resource-management",title:"Issues of Human Resource Management",fullTitle:"Issues of Human Resource Management"},signatures:"Lukáš Smerek",authors:[{id:"197295",title:"Ph.D.",name:"Lukáš",middleName:null,surname:"Smerek",slug:"lukas-smerek",fullName:"Lukáš Smerek"}]},{id:"54434",title:"Investing in Human Capital as a Key Factor for the Development of Enterprises",slug:"investing-in-human-capital-as-a-key-factor-for-the-development-of-enterprises",totalDownloads:2781,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"Small and medium-sized enterprises (SMEs) are considered to be a driving force of the economy in the world. Among the most valuable features of SMEs is their flexibility, decision-making accessibility, implementation, innovation and high adaptability to the market environment. SMEs provide for acceleration and economic growth of the country and its regions. Investment in human capital in SMEs, (meaning investment into intangible assets of the company), it is one of the ways to support this sector. In the same manner as SMEs are considered to be a driving force of the economy, human resources can be seen as its driving force, the source of success, competitiveness and added value of businesses. Human capital is one of the most valuable components of any business and that is why investment in human resources becomes a necessary step ensuring that a business prospers in a changing market environment. Current trends also point to the growing importance of investment in human capital. The future will certainly belong to those companies which pay most attention to effective management of human resources, which, in terms of time factor is an important prerequisite for growth and competitiveness of a company.",book:{id:"5826",slug:"issues-of-human-resource-management",title:"Issues of Human Resource Management",fullTitle:"Issues of Human Resource Management"},signatures:"Josef Drábek, Silvia Lorincová and Jana Javorčíková",authors:[{id:"199928",title:"Dr.",name:"Silvia",middleName:null,surname:"Lorincová",slug:"silvia-lorincova",fullName:"Silvia Lorincová"},{id:"199933",title:"Mr.",name:"Josef",middleName:null,surname:"Drábek",slug:"josef-drabek",fullName:"Josef Drábek"},{id:"199934",title:"Mrs.",name:"Jana",middleName:null,surname:"Javorčíková",slug:"jana-javorcikova",fullName:"Jana Javorčíková"}]}],onlineFirstChaptersFilter:{topicId:"440",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. 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She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. 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He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. 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Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. 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His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424836",title:"Dr.",name:"Orsolya",middleName:null,surname:"Borsai",slug:"orsolya-borsai",fullName:"Orsolya Borsai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",country:{name:"Romania"}}},{id:"422262",title:"Ph.D.",name:"Paola Andrea",middleName:null,surname:"Palmeros-Suárez",slug:"paola-andrea-palmeros-suarez",fullName:"Paola Andrea Palmeros-Suárez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Guadalajara",country:{name:"Mexico"}}}]}},subseries:{item:{id:"8",type:"subseries",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11404,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",slug:"hitoshi-tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",slug:"marcus-vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},onlineFirstChapters:{paginationCount:0,paginationItems:[]},publishedBooks:{paginationCount:6,paginationItems:[{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",publishedDate:"March 23rd 2022",editedByType:"Edited by",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",hash:"8b43add5389ba85743e0a9491e4b9943",volumeInSeries:27,fullTitle:"Vitamin K - Recent Topics on the Biology and Chemistry",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7004",title:"Metabolomics",subtitle:"New Insights into Biology and Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/7004.jpg",slug:"metabolomics-new-insights-into-biology-and-medicine",publishedDate:"July 1st 2020",editedByType:"Edited by",bookSignature:"Wael N. 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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/266861",hash:"",query:{},params:{id:"266861"},fullPath:"/profiles/266861",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()