Maximum deflections measured by laser sensor.
\r\n\tOver the years, the concept of maintenance became more comprehensive, reducing fault occurrence and increasing industrial system availability. Besides, reliability, safety, and criticality requirements were associated with the system or equipment under analysis. Maintenance strategies or schemes can be classified as corrective (run-to-break), preventive (time-based), and predictive (condition-based maintenance). Corrective maintenance is only performed after an occurrence of a fault. Therefore, it involves unexpected breakdowns, high costs, changes in the production chain, and it could lead to catastrophic events. Preventive maintenance and interventions occur based on a scheduled maintenance plan or the equipment's mean time between failures. Although it is more effective than corrective maintenance, unexpected failure may still occur by preventing most failures. Additionally, the process cost is still high, especially the costs associated with labor, inventory, and unnecessary replacement of equipment or components.
\r\n\tOn the other hand, predictive maintenance analyses the equipment condition so that a possible fault can still be identified at an early stage. Predictive maintenance aims to identify a machine anomaly so that it does not result in a fault. Such maintenance involves advanced monitoring, processing, and signal analysis techniques, which are generally performed non-invasively and, in many cases, in real-time. In the case of machines or processes, these techniques can be developed based on vibration, temperature, acoustic emission, or electrical current signal monitoring. It should be noted that monitoring such signals or parameters to verify the operating condition is called condition monitoring. Condition monitoring aims to observe the machine's current operational condition and predict its future condition, keeping it under a systematic analysis during its remaining life. In this sense, a fault condition can be detected and identified from systematic machine condition monitoring. A diagnosis procedure can be established, whereby properly investigating the fault symptoms and prognosis.
\r\n\t
\r\n\tThis book will aim to merge all these ideas in a single volume, aggregate new maintenance experiences, apply new techniques and approaches, and report field experiences to establish new maintenance processes and management paradigms.
\r\n\t
Fatigue is a common failure mode of steel bridges. About 80–90% of failures in steel structures are related to fatigue and fracture [1]. Despite the deterioration caused by environmental factors, the increasing traffic volume and weight pose a premier threat to steel highway bridges. The total number of truck passages in the 75 year life of a highway bridge could exceed 100 million [2]. With the aging of existing steel highway bridges and the accumulated damage under truck loading, the fatigue assessment for continuing service has become important for decision makings on the structure maintenance, component replacement, and other major retrofits.
\nGiven the uncertainties of the complicated traffic loading and the complexity of the bridge structure, fatigue evaluation based on field measurements under actual traffic flow is recommended by many researchers. As the quality and quantity of the available long-term traffic monitoring data and information have been improved, a set of methodologies has been developed to obtain a more realistic vehicular live load. The knowledge of actual traffic loading may reduce the uncertainty involved in the evaluation of the load-carrying capacity, estimation of the rate of deterioration, and prediction of remaining fatigue life. However, there are still some difficulties in field measurements. For example, some highway bridges are not accessible for field tests; the maintenance of monitoring system is difficult and costly, especially for long-term monitoring; some highway bridges will not even be considered for field tests with economic concerns.
\nThe results of several NCHRP reports, written by Dr. John Fisher in 1970s, have confirmed that for welded details, fatigue life is primarily a function of stress range, detail category, and the number of applied cycles. The live load of a bridge includes static and dynamic parts while the early research and studies focused on the static portion. Schilling [3] and Raju et al. [4] suggested to improve the accuracy of the fatigue truck model by adjusting the fatigue truck axle weights in proportion to an equivalent total weight calculated from the specific site load distribution. The collected weigh station measurements, or data measured in stationary weight scales, were used by Nowak et al. [5] to determine the truck-load spectra for highway bridges on highways I-75 and I-94. Later, Laman and Nowak [6] developed a fatigue-load model from weigh station measurements and calculated the statistical parameters of stress for girder bridges. The results indicated that magnitude and frequency of truck load spectra are strongly site-specific and the live load stress spectra are strongly component-specific. With the advantage of weigh-in-motion (WIM) technology, Miao and Chan developed a methodology by using 10 year WIM data for deriving highway bridge live load models for short span bridges in Hong Kong [7]. NCHRP developed a set of protocols and methodologies for using available nation-wide, state-specific, or site-specific truck traffic data collected at different U.S. sites to obtain live load models for LRFD superstructure design, fatigue design, deck design, and design for overload permits [8].
\nIn the early studies, it was commonly assumed that a certain percentage of the total weight was loaded on the front axle or rear axle for the magnitude and configuration. Further, there was no real traffic simulation considering the truck flow pattern. Bridge behavior simulations under truck loading were usually performed using the Monte Carlo method, which is a statistical projection approach with generic nature and does not consider any vehicle and driver behavior models when simulating truck traffic flow. In recent years, traffic flow simulation method has been applied to provide instantaneous information of individual vehicle by many researchers. Chen and Wu developed a general framework of modeling the live load from traffic for a long-span bridge by using the cellular automation (CA) traffic flow simulation technique. A typical four-lane long-span bridge was studied using the proposed method. Each lane was divided into cells with an equal length of 7.5 m. Three conditions, the free flow, the moderate flow, and the congested flow, were considered in the simulation. A simple comparison between the simulated static traffic load and the AASHTO LRFD HL-93 design load was conducted. The results showed that the HL-93 may be insufficient for the congested flow condition [9].
\nThis research has developed a framework for the fatigue assessment of steel highway bridges based on simulated truck loading. The proposed methodology is implemented on a steel highway girder bridge on interstate 270 (I-270) over Middlebrook Road in Germantown, Maryland. With the help of the available long-term monitoring traffic data, truck loading was also obtained through the probability-based model. Then, the three-dimensional finite element (FE) global bridge models were studied subjected to the simulated truck loading. Meanwhile, the preliminary field test and the long-term monitoring test were also conducted. The FE models were calibrated with the collected field measurements through monitoring systems, and the simulated numerical structural responses were validated. Lastly, this model has been used for identifying the cause of fatigue cracks reported in the biennial bridge inspection. Thus, the proposed methodology could be used to realistically simulate the fatigue behavior of steel highway bridges under current or future truck loading, to direct the experimental designs and instrumentation plans before performing experiments on laboratory or on site, and to better understand the fatigue mechanism and prevent the fatigue damage of steel highway bridges.
\nThe I-270 Bridge over Middlebrook road (MD Bridge No.15042) is a simple-span composite steel I-girder bridge with a span length of 140 ft. This bridge is comprised of two structures for the northbound (NB) and southbound (SB) roadways respectively, separated at the centerline. It carries three traffic lanes in the southbound and four traffic lanes in the northbound with equal lane widths of 12′-0″.
\nThe southbound superstructure provides a curb-to-curb roadway width of 61′-2″ and consists of eight identical welded steel plate girders with a composite reinforced concrete deck constructed with shear connectors. The eight girders are equally spaced at 7′-11″ and each girder has a constant web depth of 60″ throughout the entire bridge. The northbound superstructure provides a curb-to-curb roadway width of 73′-1″ and consists of nine identical welded steel plate girders with a composite reinforced concrete deck constructed with shear connector. The nine girders are equally spaced at 8′-5″ and each girder has a constant web depth of 60″ throughout the entire bridge. This bridge has a 76 degree parallel skew of its bearing lines (or 14 degree measured from normal). The cross-frames are inverted K-type braces with bottom chords only. All of them are parallel to the bearing lines. Girders of the southbound superstructure are numbered as G1 through G8 from the exterior to the centerline of the bridge. The cross section is depicted in Figure 1.
\nCross section with lane positions.
Designed in 1988, the I-270 Bridge over Middlebrook Road has been in-service for over 20 years. In addition to the deterioration caused by environmental factors, the bridge structure has also been subjected to increasing traffic volume and weight. Four fatigue cracks as marked on Figure 2 were reported in the June 2011 Bridge Inspection Report, and all in the welded connection between the lower end of the cross frame (Figure 3) connection plate and the girder bottom flange of the southbound superstructure. Figure 4(a) shows one of the four crack locations at G3B2D3 (Girder 3 Bay 2 Diaphragm 3). Therefore, only the southbound superstructure will be discussed in the following sections. Most bridge components with fatigue cracks are repaired or replaced shortly after the crack is found in an inspection. However, since the crack on the I-270 Bridge was identified on a secondary bridge member, and delaying repair would not jeopardize the safety of drivers, this crack was selected for research purposes and long-term monitoring.
\nCrack locations and sensor placements on the framing plan.
Cross frame detail.
Crack locations and sensor placements: (a) details at G3B2D3 and (b) details at G3B3D3.
The field test of the I-270 Bridge was conducted through a Wireless Integrated Structural Health Monitoring System sponsored by the U.S. Department of Transportation, Office of the Assistant Secretary for Research and Technology (USDOT/OST-R). This smart bridge condition monitoring system, termed the ISHM system, features a number of technology innovations, including remote sensing capability, piezo paint acoustic emission sensors, wind and solar based energy harvesting devices to power the sensor network, high-speed wireless sensing ability and advanced data analysis methods for remaining life estimation of aging bridges. Through successful advancement and commercialization in the state-of-the-art technology of remote infrastructure sensing, the ISHM system is promising to reduce life cycle costs while significantly maintaining the sustainability of the highway infrastructure in the US.
\nThe main data acquisition systems used in this test consisted of a PXI-based data acquisition system by National Instruments, which was used for data collection by the BDI strain transducers, string pots and Acoustic Emission (AE) sensors, and a multi-channel data acquisition equipment CR5000 manufactured by Campbell Scientific, Inc., which was used for the extra BDI strain transducer. Types of sensors used in this project were: (1) piezoelectric paint AE sensors; (2) wireless accelerometers; (3) laser sensor; (4) ultrasonic distance sensors; (5) BDI strain transducers; and (6) string pots. Sensors were strategically placed where the cracks on the SB bridge were identified and their related strain, AE or supplemental data can be collected by the data acquisition system and later used for validating the FE models. The instrumentation plan is shown in Figure 2. Girder displacement and stress range records due to truck traffic were part of the field measurements in this study.
\nA total of four wireless accelerometers were used to monitor the vibration responses of the bridge. Wireless sensors were installed on four girders (Girders 2–5) and acceleration data were acquired at 100 Hz sampling rate synchronically. The acceleration data were used to provide modal frequency information that was used to calibrate the finite element model of the bridge. The fundamental frequency measured is 3.22 Hz, which was very close to the value of the first vertical mode from the finite element analysis of 3.24 Hz discussed in the following sections.
\nBoth laser sensor and ultrasonic distance sensors were used to measure the dynamic deflection of the bridge. Only one laser sensor and one ultrasonic distance sensor were used each time. The measured deflection value from the laser sensor agreed well with the string pot, and its accuracy was also validated by the fundamental frequency indicated by fast Fourier transform (FFT) of the laser sensor measured deflection data. The measured maximum deflection of the I-270 bridge over Middlebrook Road under traffic loading is summarized in Table 1.
\nGirder number | \n3 | \n4 | \n5 | \n
---|---|---|---|
Max D (in) | \n0.2598 | \n0.2717 | \n0.2480 | \n
Maximum deflections measured by laser sensor.
Cracks occur in the direction perpendicular to the direction of principal tensile stress. To assess the driving force of the fatigue cracks in the connection welds, strain gages were placed vertically on the connection plate just beyond the tip of the existing crack. Strain gages were also placed longitudinally on the girder flanges to correlate with the occurrence of vehicular loads. For comparison with the results from analytical methods, field testing is applied as it is the most accurate approach since no assumptions need to be made for uncertainties in load distribution such as unintended composite action between structural components, contribution of nonstructural members, stiffness of various connections, and behavior of the concrete deck in tension. The actual strain histories experienced by bridge components are directly measured by strain gages at the areas of concern. The effects of varying vehicle weights and their random combinations in multiple lanes are also reflected in the measured strains.
\nBDI 1-4 strain transducers were placed on both sides of the connection plates while BDI 5-8 strain transducers were placed at the top and bottom flanges on Girders 3 and 4 (Figure 2). Figure 5 shows the measured stresses on the flanges and connection plates, respectively. The maximum stress measured at the bottom flange was 1.604 ksi in tension for BDI 3215 on the bottom flange of Girder 3 due to regular traffic loading, which was very low comparatively. As for the connection plates, the maximum stresses were 16.18 ksi in tension for BDI 1641 on Girder 3 and 16.1 ksi in tension for BDI 1644 on Girder 4 (Figure 5).
\nBDI strain transducer measurements of connection plates and flanges (positive indicates compression; 1641 G3 cracked side; 1642 G3 uncracked side, 1643 G4 uncracked side and 1644 G4 cracked side).
The traffic data that is used to simulate the traffic flow were the time-varying vehicle count data obtained from the Traffic Monitoring System Program (TMSP); operated and maintained by the Highway Information Services Division under Maryland Department of Transportation, State Highway Administration (MDSHA) [10]. The TMSP has been responsible for the collection, processing, analysis, and management of Maryland highway traffic data since 1997. Under this program, MDSHA has implemented 79 permanent continuous automatic traffic recorders (ATRs) counting traffic continuously throughout the year, and over 3800 short-term (48 hour) program count locations throughout the state, with data taken during the week on either Tuesday and Wednesday or Wednesday and Thursday to reflect typical weekday travel patterns. These monitoring systems are installed across Maryland and monitor most of the arterials, freeways, and interstates. Figure 6 displays the location of several ATRs on I-270.
\nObservation points on I-270 in Montgomery County.
The TMSP has also created an Internet Traffic Monitoring System (I-TMS) that provides access to detailed traffic count data. On the I-TMS, the user can select an individual location to view reports (class, volume, lane distribution, etc.). Based on the hourly traffic volume, one typical day was divided into four different time periods: midnight, early morning and night, morning peak hour, and noon to evening, as shown in Table 2. The durations for these four time periods are 5, 5, 5, 9 hours, respectively. The average hourly volume varied from 505 to 4215, and the truck percentage also varied from 10.39 to 20.10%. Lane distribution of I-270 Bridge over Middlebrook Road is shown in Table 3. The main purpose of this time division is to realistically simulate the major characteristics of the traffic flow for each time period.
\nTime period | \nTime | \nAverage total volume (no. of vehicles per hour) | \nPassenger car (no. of vehicles per hour) | \nTruck by axle number (no. of vehicles per hour) | \nTruck percentage | \n||||
---|---|---|---|---|---|---|---|---|---|
2 | \n3 | \n4 | \n5 | \n6 | \n|||||
Midnight | \n23:00–24:00 0:00–3:00 (5 hours) | \n505 | \n403 | \n25 | \n2 | \n3 | \n69 | \n3 | \n20.10% | \n
Early morning and night | \n4:00–5:00 19:00–23:00 (5 hours) | \n1934 | \n1712 | \n55 | \n4 | \n7 | \n150 | \n6 | \n11.40% | \n
Moring peak | \n5:00–10:00 (5 hours) | \n4215 | \n3759 | \n113 | \n7 | \n14 | \n310 | \n12 | \n10.82% | \n
Noon to evening | \n10:00–19:00 (9 hours) | \n3021 | \n2707 | \n78 | \n5 | \n9 | \n213 | \n8 | \n10.39% | \n
Traffic condition under different time period.
Vehicle type | \nLeft lane (%) | \nMiddle lane (%) | \nRight lane (%) | \n
---|---|---|---|
Total (passage car and truck) | \n31.87 | \n30.62 | \n37.51 | \n
Truck | \n1.45 | \n44.84 | \n53.71 | \n
Lane distribution of one typical day.
Following the specifications in the Guide Specifications for Fatigue Evaluation of Existing Steel Bridges (1989), weigh station measurements were collected at Hyattstown Weigh Station. From these measurements, a gross-weights histogram was obtained for the truck traffic, which was used to calculate the effective gross weight of the fatigue truck. The Hyattstown Weigh and Inspection Station is located approximately 10 miles north of I-270 Bridge over Middlebrook Road, along Interstate 270 (I-270). Around 2200 samples during 1 year were chosen as the database to generate the truck weight and configuration. The measured data were filtered before the statistical analyses were made, where five samples were deleted. All the trucks were cataloged into seven classes based the number of axles (Figure 7). It is clear that 2-axle trucks and 5-axle trucks were the majority, which occupies about 24.87 and 67.99%, respectively. The 3-axle trucks, 4-axle trucks and the heaviest 6-axle trucks and over accounted for 1.61, 2.98 and 2.55%, respectively, which adds up to 7.14% in total.
\nTruck class distribution.
Because of the limitation of the traffic simulation software CORSIM, only three different types of trucks can be defined during traffic simulation: the small truck, the medium truck, and the large truck. Since 2-axle trucks and 5-axle trucks were the majority, the small truck was defined to consist 2-axle trucks and 3-axle trucks, and the medium truck to include 4-axle trucks and 5-axle trucks. For safety consideration, the heaviest 6-axle trucks and over were also considered as the third type, although it only takes a very small percentage.
\nThe effective gross weight of the fatigue truck was computed from Eq. (1)
where
Fatigue truck configurations: (a) small truck; (b) medium truck; and (c) large truck.
As an intercorrelated component of a whole transportation network, the actual traffic flow through a bridge is affected by the traffic on the connecting roadway segments. Therefore, to realistically capture the major characteristics of the traffic flow, a road network system consisting of the bridge, highway, and two neighboring ramps was studied in the present work. The detailed procedure is summarized in four steps:
Build the simulation network (Figure 9) in TSIS 5.1 [11] around the I-270 over Middlebrook Road based on the background map obtained from Google Maps. The background map is adjusted to the correct scale, and the simulation network is drawn along the real roadway segment. The network contained the mainline of I-270 and adjacent on-ramps of the bridge in the study. Since the focus is on the southbound of the bridge, the network only contains one-way southbound link. The simulation time is set to be 1 hour.
Use the time varying vehicle count data collected from nearby detectors, which were placed on the I-TMS website, and combine with the weigh station measurements collected from the Hyattstown southbound station as the input data for the simulation model. The truck count data from the vehicle count report are converted to truck percentage (truck count/total vehicle count) as the input for CORSIM simulation.
Set three different types of trucks corresponding to fatigue trucks generated in the last section. Install three loop detectors at the bridge in the created simulation network, one for each lane to record the speed, type, and passage time of the detected vehicles.
After the simulation network is created, the traffic demand is input and calibrated, and the detectors are installed, the CORSIM simulation can begin. The simulation provides the following meaningful results for the analysis. First, it records the animation of the simulation, which is used to observe the passage time of the trucks. Second, it provides text output including the volume and speed statistics by each interval (set to be 1 s here). Combining the above two outputs, the passage time and the lane occurred and speed of the truck could be successfully matched.
Traffic simulation network.
The results (Table 4) could provide vehicle position and speed at each time step of the simulation. It was found from the results that the 20 min simulation period currently used can lead to stable pattern and matched field monitoring results. Details of the field monitoring are reported in a separate companion paper,
Time periods | \nCORSIM | \n||
---|---|---|---|
Average speed (mph) | \nNumber | \nAverage headway (s) | \n|
Midnight | \n53.69 | \n32 | \n37.5 | \n
Early morning and night | \n52.94 | \n78 | \n15.38 | \n
Morning peak | \n35.45 | \n165 | \n7.27 | \n
Noon to evening | \n42.07 | \n98 | \n12.24 | \n
CORSIM simulation results.
To investigate the fatigue performance of the bridge, a three-dimensional finite element model was developed for linear-elastic structural analysis using the CSiBridge [12], as depicted in Figure 10. The model of the southbound superstructure consisted eight I-girders. The concrete deck, the eight I-girders, and connection plates which connected cross-frames to the girders were modeled by shell elements, while all the cross-frames were modeled by spatial frames along their center-of-gravity. Special link members were defined to connect girder elements and concrete deck elements at the actual spatial points where these members intersect. The translations in the x-, y-, z-directions were fixed at the abutments to represent the actual characteristics of support and continuity. It is complicated to establish a comprehensive finite element model of a large practical structure for fatigue damage analysis, since the finite element model should embody the sectional properties of structural members (e.g., the weld between two members). In addition, fatigue damage is a local failure mode and often occurs around welded regions. Therefore, a global model with refined meshing around the welded connection between the connection plates and the bottom flanges was constructed for analysis.
\nFinite element model of I-270 Bridge in CSiBridge: (a) isometric view of FEM for I-270 Bridge and (b) zoom-in view (refined meshing around the welds).
The accuracy of a finite element analysis depends on the mesh size of the elements; the smaller the size of the elements, the greater the accuracy of the analysis. However, the desire for increased calculation accuracy can significantly increase the computational time. Therefore, in finite element analysis, a convergence test is used to determine appropriate mesh size for a model without increasing the computation time. The measurement of a finite element model’s mesh size depends on the purpose of the model. Since this bridge model is to investigate the vertical stress or shear stress in the cracked connection weld, it needs to have a very fine mesh in the connection area but needs to also transit gradually to coarser meshes because otherwise the model would become unnecessarily too large. A more uniform mesh may then be used along the rest of the bridge length for all the girders. However, there are multiple parameters related to the accuracy of a two-dimensional or three-dimensional finite element model, including the dimensions and aspect ratios of the elements for the girder top flange, bottom flange, and web, as well as the bridge deck.
\nTo simplify the convergence test for these finite element models of the I-270 Bridge over Middlebrook Road, a consistent refined mesh around the weld region was employed in all the models, and the maximum element size was used to control the uniform mesh along the bridge longitudinal length for all the girders and the deck. The determination of the first natural frequency was used as the measurement during the convergence test. As the maximum mesh size changed from 1000 in to 0.5 in, the results of the first natural frequency gradually increased from 2 to 3.20 Hz. The results of the first natural frequency were all beyond 3 Hz when the maximum mesh size of the finite element models was smaller than 200 in, which means that the error rate of the first natural frequency was under 6.25%. When the maximum mesh size was equal to or less than 50 in, the results of the first natural frequency were accurate enough with an error rate less than 2%, and were therefore used as the basis for the selection of an accurate finite element mesh in CSiBridge.
\nModal analysis is used to determine the vibration modes of a structure. These modes are useful to understand the behavior of the structure. They can also be used as the basis for modal superposition in response-spectrum and modal time-history load cases. An eigenvector analysis was used to determine the undamped free-vibration mode shapes and frequencies of the system.
\nThe first six mode shapes of torsion, vertical and lateral modes are shown in Figure 11. To validate the finite element models, experimental data from the field test and numerical results from CSiBridge were studied. In the numerical study, the bridge was only subjected to dead load. The results obtained from the finite element model and field measurements were compared, and the differences of most of the compared frequencies were less than 6%, which was considered acceptable for the finite element analysis. All the mode shapes matched well with each other. Therefore, the CSiBridge model was considered reasonably accurate for the purposes of this study.
\nMode shapes of I-270 Bridge over Middlebrook Road in CSiBridge: (a) mode shape 1 (first torsion), (b) mode shape 2 (first vertical), (c) mode shape 3 (second torsion), (d) mode shape 4 (first lateral), (e) mode shape 5 (second vertical), and (f) mode shape 6 (third torsion).
Possible driving forces for the fatigue cracks shown in Figure 4 are vertical tensile stress, horizontal shear stress, or the principal tensile stress due to their combined actions along the connection welds. Live load induced stresses from the welded connections between the cross-frame connection plates and the girder bottom flanges were extracted in the refined portion of the finite element models. A total of four different traffic loading cases obtained from the traffic simulation were studied as described below and the key results were summarized in Table 5. For all the four cases analyzed, the longitudinal positions of trucks remained the same as for the previous deflection studies.
\nTime period | \nMax vertical stress | \nMax shear stress | \nMax principal stress | \n
---|---|---|---|
Midnight | \n6.665 | \n2.165 | \n7.629 | \n
Early morning and night | \n7.586 | \n2.563 | \n8.70 | \n
Morning peak | \n12.94 | \n4.327 | \n14.84 | \n
Noon to evening | \n7.905 | \n2.664 | \n9.061 | \n
Stresses in cross frame connection plate-to-girder bottom flange connections at G3 without dynamic impact (FE results) (ksi).
There were many live load cases that could have produced significant tensile stresses in the connections of concern. The simulated truck loading contained most of the possible truck loading patterns. Magnitudes of tensile stresses in the connection plates depend on the magnitudes and positions of the wheel loads of crossing vehicles. The stresses listed in Table 5 are for illustration and are taken from the connection plates at Girder 3 for the four different time periods. A comparison of live load cases for the four different time periods suggest that live loads during morning peak may have caused the highest tensile stress of 12.94 ksi in the connection of concern. All the shear stresses in the connection welds were much lower than the vertical stresses at the same spot during each time period. Considering a factor of dynamic load allowance, the dynamic maximum vertical stress was 16.822 ksi, which perfectly matched with the field measurements.
\nThe results of the finite element analysis were verified and validated with the field test data; all the cracks were located on the western sides of the connection plates. The vertical stress near the welded edges of the connection plates followed the same pattern; the western sides of the connection plates were under tension; and the eastern sides of the connection plates were under compression. To further discuss the cause of this phenomenon, a series of controlled FEM tests were established for the comparison study.
\nAccording to the design drawings and the existing bridge construction, cross-frame connection plates and bearing stiffeners are normal to the girders and connection plates connecting the cross-frames are bent. Therefore, for the original FE model, all the connection plates were normal (90°) to the girders and the cross-frames are parallel to the two abutments with a skew angel of 76°. For the controlled model, all the connection plates were parallel to the cross frames with the same skew angel of 76 degree (Figure 12).
\nSkewed (right) and non-skewed (left) connection plates.
The K-type bracing system was modeled for studying the influence of the bracing system configuration on the stress distribution in the connection plates. The K-type cross-frame without top chord was modeled in the original FE model, while the K-type cross-frame with top chord was modeled in the controlled model. The cross section of the diagonal and bottom chords was employed for the additional top chords (Figure 13). All the models were subjected to the same live load case. The live load case was defined as an HS20 truck in the right traffic lane passing across the bridge from north to south at the speed limit of 55 mph. The vertical stress at the crack location (Girder 3 Diaphragm 3) and the axial forces in the top chord located at Diaphragm 3 Bay 2, directly connecting with the crack side, were analyzed and are shown in Table 6. Maximum vertical stresses in the model with the non-skewed connection plates were much higher than the stresses in the model with the skewed connection plates. The maximum axial forces in the models during the load time history analysis were quite small; the values were only 3.47 and 1.12 kip. The values of maximum vertical stresses did not change much due to the addition of a top chord. It demonstrates that the connection plate configuration has a significant influence on the stress distribution in the connection plates, while the top chord of K-type bracing plays a negligible role in this situation. Further, the results showed that X-type or K-type bracing made no difference on the vertical stress at the crack location.
\nConnection plates configuration | \nBracing system configuration | \nMaximum axial force (kip) | \nMaximum vertical stress of crack location (ksi) | \n
---|---|---|---|
Non-skewed connection plats | \nK-frame without top chord | \n— | \n13.50 | \n
K-frame with top chord | \n3.47 | \n12.66 | \n|
Skewed connection plats | \nK-frame without top chord | \n— | \n0.33 | \n
K-frame with top chord | \n1.12 | \n0.30 | \n
Maximum vertical stress and axial force through simulated numerical analyses.
K-frame without top chord (left) and K-frame with top chord (right).
The measured high vertical tensile stress around the connection plate welds was proven caused by the configuration of the connection plates instead of the configuration of the cross-frames. The connection plates, which were bent to be parallel to the skewed abutment, induced torsion in the connection plate welds. Differential displacements between the girders caused one diagonal cross frame to be in tension and the other diagonal to be in compression. Measured vertical tensile stresses from field tests up to 16.1 ksi in the connection plate explains why fatigue cracks have occurred at their connections to the girder bottom flange. Girders 3 and 4 are located under the slow-moving lane which most heavy trucks are using while Girders 1 and 2 support a shoulder and thus larger differential deflections typically occur between Girders 2 and 3 (with up to 0.5″ to 0.75″ vertical deflections due to observed live load). The connection plate configuration is a key factor in the stress distribution that results in the connection plates.
\nThe passage of trucks on the bridge deck can cause vertical tensile stresses in the welded connections between cross-frame connection plates and girder bottom flanges. These stresses were highest at the outer edge of the connection plate where all the existing four fatigue cracks on the I-270 Bridge over Middlebrook Road were located. Girder 4 located at the center left of the middle traffic lane, and Girder 3 located at the center right of the right traffic lane, are the most critical locations for the bridge deflections and the resulting stresses.
\nThe live load-induced stresses in the connection plates were localized around the welded connections and would not be anticipated to spread from the bottom to the top of connection plates. At the same face of the connection plate, both tensile and compressive stresses were observed at the symmetric positions around the girder web. The cracked side of the connection plates was always under tensile stress, while the uncracked side was always under compressive stress during each time period. At the same location of the cracked side, the north face and the south face sustained the same stresses, (although opposite directions). It was proved that the high vertical tensile stress around the connection plate welds was caused by the configuration of the connection plates instead of by the configuration of the cross-frames. The connection plates, which were bent to be parallel to the skewed abutment, induced torsion in the connection plate welds. The connection plate configuration is a key factor in the stress distribution that results in the connection plates.
\nDifferent from the explicit equation-based method, the proposed approach combines a comprehensive traffic loading model, which includes information on vehicle types, axle weights, axle spacing, and the lane occupation, and a detailed 3D FE model, which enables fatigue analysis on unreachable or complicated details where complex stress conditions may exist. The proposed approach may be used as a tool accompanying a monitoring program to find the stresses in unmonitored details or to reduce the frequency of structural health monitoring resulting in lower costs in fatigue assessment. In such case, the proposed approach also provides a tool to predict the fatigue reliabilities of these hard-to-reach details. When combined with the fracture damage mechanics, the proposed approach can help understand the accumulation of fatigue damage and crack propagation.
\nThis work was partially sponsored by the US Department of Transportation’s Office of the Assistant Secretary for Research and Technology (USDOT/OST-R) under The Commercial Remote Sensing and Spatial Information (CRS&SI) Technologies Program. This support is acknowledged and greatly appreciated.
\nPeptic ulcers are not a modern disease. Ulcers have plagued mankind since the age of Hippocrates (born 460 BCE), who had been known to use honey and mastic oil for symptomatic relief. Record of surgery for a gastric ulcer was found written in stone in the temple of Aesculapius at Epidaurus as described by Goldstein in 1943: “A man with an ulcer in his stomach…Asklepios opened his stomach, cut out the ulcer, sewed him up again, and loosed his bonds. He went away whole, but the chamber was covered with his blood.” [1], (Goldstein HI. Ulcer and cancer of the stomach in the middle ages. J Internal Coll Surgeons. 1943;
Exactly 100 years after Rydygier’s groundbreaking surgery, pathologist Dr. Robin Warren met Dr. Barry Marshall at the Royal Perth Hospital, Australia during internal medicine fellowship training. Sharing an interest in the physiology of gastritis, they spent 2 years studying the stomach and discovered the spiral bacteria
In the wake of Marshall and Warren’s achievement, new therapies evolved against peptic ulcer disease. Proposed treatments have been published since the 1990s and updated to reflect the advancements in diagnostics, resistance to antibiotics, and geographic prevalence patterns. General regimens include acid-reducing agents and various antimicrobials [1]. Medical therapy has proven to be largely successful in combating H. Pylori, with eradication rates of 70–95% across several trials [5, 6]. The patterns of peptic ulcer disease have therefore shifted from a once-common surgical problem to an entity treated effectively through oral medications.
Several studies have shown that hospitalizations for peptic ulcer disease have declined since the 1980s [7, 8, 9, 10]. However, despite improvement due much in part to the advancement of medical therapy, PUD persists in the population with a lifetime prevalence in of 5–10% and incidence of 0.1–0.3% yearly. Roughly 10–20% of these patients experience complications, including hemorrhage and less commonly, perforation [11]. The sequelae of PUD complications are often life-threatening and it is in these cases that surgical evaluation must be sought.
The current role for surgery in peptic ulcer disease is largely in the emergent setting, with bleeding, perforation, and obstruction as the major indications for intervention.
In patients with perforated peptic ulcer disease with significant pneumoperitoneum, extraluminal contrast extravasation on diagnostic study, or signs of peritonitis, operative treatment is recommended [11]. It is further suggested that the operation is performed promptly (within 24 hours) to decrease morbidity and mortality [12, 13]. Endoscopy currently has no role in the treatment of acutely perforated peptic ulcers. The laparoscopic and open approaches have both been described in the management of perforated peptic ulcers. Selection of surgical approach is based at least partially on surgeon experience and available equipment. In unstable patients, open surgery is favored. Several studies have pointed to comparable outcomes between open and laparoscopic surgery including overall postoperative complication rate, mortality, and reoperation rate. Laparoscopic surgery may have advantages in reducing hospital stay, lowering rate of surgical site infection, and less postoperative pain when compared to open surgery [14, 15, 16]. Robotic-assisted laparoscopic surgery has not been widely used for perforated or bleeding peptic ulcers and is not currently recommended in an emergent setting.
Several factors will tailor the ultimate surgical intervention to be performed. These include ulcer location, ulcer size, history of prior surgeries, prior ulcer treatment and patient stability. With gastric ulcers, excision of the ulcer with reconstruction of the resultant defect is the operative goal. For gastric ulcers located in the greater curvature, antrum, or body of the stomach, a wedge excision of the ulcer usually can be performed easily with linear staplers. Wedge resection results in both closure of the perforation and obtaining a tissue sample for biopsy—a critical consideration give the reported 4–14% rate of malignancy in perforated gastric ulcers [17]. Ulcers along the lesser curvature present a challenge given the proximity to the GE junction and the left gastric arterial flow. In distal lesser curvature ulcer cases, a distal gastrectomy may be considered. The proximal ulcer close to the gastroesophageal junction may require a subtotal gastrectomy with a subsequent Roux-en-Y esophagogastrojejunostomy.
It is important to note that perforations of the pyloric channel and the duodenum are functionally grouped together. Treatment of a small perforated duodenal ulcers (<2 cm) classically involves pedicled omentum placed into the defect as a repair. Primary repair, with or without an omental patch has also been described. Historically, an omental patch has been advocated to buttress a primary repair; however, recent studies point to no meaningful difference in leakage rate or mortality with addition of this step [18]. The operative approach to larger duodenal ulcers requires thorough calculation and a large range of interventions are available based on each patient’s individual scenario. An omental patch repair in duodenal ulcer perforations that are greater than 2 cm in size have an increased rate of postoperative leaks (up to 12%) [17]. Partial gastrectomy with subsequent reconstruction via a gastroduodenostomy (Billroth I) or gastrojejunostomy (Billroth II) may be performed to address the ulcer and restore gastrointestinal continuity. Additionally, the jejunum can be used in a pedicled graft or serosal patch approach. The involvement of the duodenum containing the ampulla of Vater is a particularly arduous challenge. When in doubt, the integrity of the ampulla should be investigated with intraoperative cholangiography. Damage-control procedures such as the Roux-en-Y duodenojejunostomy or pyloric exclusion may be warranted in patients with tenuous stability. The duodenostomy tube should be considered as last-resort procedure when the patient’s hemodynamic status on the operating table will not allow for a more complex operation. An emergent Whipple comes with a high rate of morbidity and mortality and should generally not be attempted.
The evolution of endoscopic skills and technology in the last several decades has brought this technique to the forefront of bleeding ulcers and often obviates the need for surgical intervention. Early endoscopy (within 24 hours) is first-line therapy with the employment of therapeutic endoscopic interventions as needed, along with the initiation of parenteral proton pump inhibitors [11]. Roughly 10–20% of patients will have recurrent bleeding despite endoscopic therapy, at which time repeat endoscopy should be considered [19]. Patients who remain hemodynamically stable thereafter without high-risk ulcer features may then be safely discharged with continued oral PPI management. Surgery becomes warranted in cases of bleeding peptic ulcers when endoscopy fails or when the patient is deemed high-risk of a rebleeding event. Large ulcers (>2 cm) and hypotension at rebleeding are reported independent factors of predicting failure in further endoscopic treatment. Other features reported to prompt surgical consultation for further management include pulsatile bleeding, visible blood vessels in posterior duodenal ulcers, and transfusion requirement greater than 6 units of blood in the first 24 hours [20].
The surgical procedures currently used in bleeding gastroduodenal ulcers are on a spectrum of minimal to definitive interventions. The principal objective in life-saving surgery is hemorrhage control, which may be achieved through simple intraluminal oversewing or ligature, plication, or excision of the ulcer and repair of the defect [20]. The initial procedure may also include control of the arteries of the stomach or duodenum through direct ligation.
The management of emergent PUD has largely left out procedures that were designed to address the underlying problem--a once common consideration in all patients with PUD up until the 20th century. Acid-reducing procedures historically included division of the vagus nerve at various points in order to decrease the acetylcholine-mediated secretion of acid from parietal cells [21].
The truncal vagotomy is the division of the anterior and posterior trunks of the vagus nerves roughly 4 cm proximal to the gastro-esophageal junction. Stimulation of parietal cells is interrupted through this procedure; however, the lack of sympathetic input to the stomach results in a lack of relaxation, thereby decreasing the propulsion of solids from the stomach into the small intestine. Therefore, a concomitant drainage procedure, consisting of a pyloroplasty or antral resection would be performed. A selective vagotomy is similar but involves division of the vagus nerves at the more distal anterior and posterior branches after the level of the celiac and hepatobiliary branching. The highly selective vagotomy (HSV) was tailored to avoid the need for a drainage procedure. The HSV involves division of the nerve fibers supplying the parietal cells of the fundus and body of stomach, sparing the “crows’s foot” fibers innervating the antrum and pylorus. Given the rise of medical management, the role of the vagotomy with or without drainage procedures in peptic ulcer disease is limited to very few cases [22].
The main indication for consideration of an acid-reducing procedure are patients whose disease is refractory to medical management or those who cannot reliably participate or tolerate proton-pump inhibitors. Specifically, it is cases of duodenal ulcers (Type II and III) in which a vagotomy may be considered--gastric ulcers (TYpe I, IV) are not related to acid hypersecretion and therefore resection alone is indicated. In emergent situations, including bleeding duodenal ulcers and perforated duodenal ulcers, the use of a vagotomy is debated and is often surgeon-dependent. In general, the presence of peritonitis, shock, abdominal abscess, delay in treatment over 24 hours, or severe concurrent medical illness are contraindications to lengthening the surgery by adding a vagotomy to the rest of the surgical management plan [22, 23].
In the era of rapidly advancing surgical instruments and techniques, innovations in peptic ulcer disease surgery are rising in efforts to improve patient outcomes. The robotic platform is emerging as a feasible alternative to surgical treatment in the elective settings for many diseases. There have a been case reports of gastric resections performed safely with the assistance of the surgical robot, and whether the robot has a wider role for peptic ulcer disease merits exploration [24, 25]. Most prior reports of robotic assisted laparoscopic surgery for the stomach are those done for malignancy.
The pedicled omental plug for a large duodenal ulcer is a described twist on the classic omental patch closure. In this procedure, a nasogastric tube is inserted through the oropharynx and down through the perforation. A tongue of omentum is then secured to the tube via sutures and withdrawn into the stomach, where it is sutured to the ulcer edges. This omental plug shows promise, as was associated with a lower recurrent leak and duodenal stenosis rate in a randomized trial comparison against the standard omental patch [26]. Falciform flaps may be a feasible option in patients who do not have a viable omentum [27].
With the introduction of SARS-CoV-2 to the world’s collective biome we have observed unprecedented patterns of illness, with both the aversion of presenting to an affected hospital and the virus itself affecting disease across multiple organ systems. We here present a look at the relationship, if any, between COVID-19 and peptic ulcer disease.
It is well-known that COVID-19 presents with respiratory symptoms; however, several other manifestations are being seen. In one study comprised of over 20,000 patients, up to 29% had enteric symptoms including abdominal pain, nausea, vomiting, and diarrhea [28]. The pathophysiology of gastrointestinal tract manifestations of COVID-19 is thought to stem from several biochemical mechanisms including infection of the GI tract/liver leading to cellular inflammation and damage, dysbiosis enhancing the inflammatory response and cytokine storm, and affliction of the neuroenteric system [29].
GI bleeding is a reported, though less common manifestation associated with COVID-19. A rather high prevalence of PUD complicated by bleeding was noticed in one cohort of patients with moderate-to-severe ARDs caused by COVID-19 [29]. In another study performed on COVID-positive hospitalized patients undergoing endoscopy (n = 106), one-fourth of the studied population had peptic ulcers while an additional 16% had erosive/ulcerative gastro-duodenopathy [30]. The mainstay of treatment in peptic ulcer disease is proton-pump inhibitors; however, at least one study has demonstrated that PPI treatment is associated with worse outcomes in those infected by SARS-CoV-2 and development of COVID-19 when compared to individuals who are not taking a PPI [28]. The mechanism responsible for this finding remains unclear.
Another factor to consider in patients afflicted with peptic ulcer disease is the pattern of behavior in seeking medical evaluation during a pandemic. As the admissions for COVID-19 related respiratory illnesses increased dramatically, several hospitals reported decreased admissions and emergency medicine visits for non-COVID related diseases [31, 32, 33]. Theories concerning this trends in admissions during the pandemic include failure to present to a hospital secondary to fear of contracting COVID-19, which may have made some cases of illness more profound up to the point of death in the community [33]. The first United States Coronavirus epicenter in New York performed a multicenter study looking specifically at emergent general surgery admissions. Comparison to prior years indicated that there was an overall decrease in admissions with an overall increase in mortality. Peptic ulcer disease was one of the seven diagnoses that was observed [34]. A delay of 12 hours was found in 10 cases of complicated peptic ulcer disease in one institution during a two-month period [35]. The question arises if the increase in mortality is at least in part attributable to delayed presentation.
The full clinical spectrum of COVID-19 has not yet fully been elucidated. There is surprisingly limited data on the relationship between COVID-19 and peptic ulcer disease. The pathogenesis of ulcers in the setting of SARS-CoV-2 affliction may be related to direct gastric epithelial damage, stress resulting from the acute disease, or active mucosal inflammation sustained by cytokine storming [36]. Development of treatment guidelines in COVID-19 positive patients who sustain gastrointestinal manifestations of disease warrants further investigation.
Peptic ulcer disease remains a healthcare issue across the world and requires an interdisciplinary approach. In linking H. Pylori and NSAID use to peptic ulcers, pioneering efforts in controlling PUD have largely been seen in the primary care setting. However, complications from PUD persist in the population, and surgical intervention will continue to play a role in the very worst of the disease burden. It is therefore the responsibility of the surgical community to advance care through innovation of technique to provide optimal outcomes. This is especially true in the era of a pandemic where healthcare dynamics are adversely affected.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Küden"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"142",title:"Soil Science",slug:"environmental-sciences-soil-science",parent:{id:"12",title:"Environmental Sciences",slug:"environmental-sciences"},numberOfBooks:5,numberOfSeries:0,numberOfAuthorsAndEditors:145,numberOfWosCitations:241,numberOfCrossrefCitations:184,numberOfDimensionsCitations:394,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"142",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10005",title:"Applications of Biochar for Environmental Safety",subtitle:null,isOpenForSubmission:!1,hash:"b8356a04f22509c43c19b3be88fa79a0",slug:"applications-of-biochar-for-environmental-safety",bookSignature:"Ahmed A. Abdelhafez and Mohammed H. H. Abbas",coverURL:"https://cdn.intechopen.com/books/images_new/10005.jpg",editedByType:"Edited by",editors:[{id:"196849",title:"Dr.",name:"Ahmed",middleName:null,surname:"Abdelhafez",slug:"ahmed-abdelhafez",fullName:"Ahmed Abdelhafez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6909",title:"Soil Contamination and Alternatives for Sustainable Development",subtitle:null,isOpenForSubmission:!1,hash:"416bc69bab575d19fd85277f6f020e0c",slug:"soil-contamination-and-alternatives-for-sustainable-development",bookSignature:"Dinora Vázquez-Luna and María del Carmen Cuevas-Díaz",coverURL:"https://cdn.intechopen.com/books/images_new/6909.jpg",editedByType:"Edited by",editors:[{id:"169742",title:"Dr.",name:"Dinora",middleName:null,surname:"Vázquez-Luna",slug:"dinora-vazquez-luna",fullName:"Dinora Vázquez-Luna"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6316",title:"Peat",subtitle:null,isOpenForSubmission:!1,hash:"6f47ea9e0e0a431c0bd28420154a4727",slug:"peat",bookSignature:"Bülent Topcuoğlu and Metin Turan",coverURL:"https://cdn.intechopen.com/books/images_new/6316.jpg",editedByType:"Edited by",editors:[{id:"194133",title:"Prof.",name:"Bülent",middleName:null,surname:"Topcuoğlu",slug:"bulent-topcuoglu",fullName:"Bülent Topcuoğlu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5358",title:"Soil Contamination",subtitle:"Current Consequences and Further Solutions",isOpenForSubmission:!1,hash:"e4d136df9f1658ae17f3ba7b3c992460",slug:"soil-contamination-current-consequences-and-further-solutions",bookSignature:"Marcelo L. Larramendy and Sonia Soloneski",coverURL:"https://cdn.intechopen.com/books/images_new/5358.jpg",editedByType:"Edited by",editors:[{id:"14764",title:"Dr.",name:"Marcelo L.",middleName:null,surname:"Larramendy",slug:"marcelo-l.-larramendy",fullName:"Marcelo L. Larramendy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3547",title:"Applied Bioremediation",subtitle:"Active and Passive Approaches",isOpenForSubmission:!1,hash:"adbc7f00ff076669e6453badde052d64",slug:"applied-bioremediation-active-and-passive-approaches",bookSignature:"Yogesh B. Patil and Prakash Rao",coverURL:"https://cdn.intechopen.com/books/images_new/3547.jpg",editedByType:"Edited by",editors:[{id:"164249",title:"Dr.",name:"Yogesh",middleName:"Bhagwan",surname:"Patil",slug:"yogesh-patil",fullName:"Yogesh Patil"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:5,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"45214",doi:"10.5772/56157",title:"Bioremediation of Waters Contaminated with Heavy Metals Using Moringa oleifera Seeds as Biosorbent",slug:"bioremediation-of-waters-contaminated-with-heavy-metals-using-moringa-oleifera-seeds-as-biosorbent",totalDownloads:7805,totalCrossrefCites:19,totalDimensionsCites:41,abstract:null,book:{id:"3547",slug:"applied-bioremediation-active-and-passive-approaches",title:"Applied Bioremediation",fullTitle:"Applied Bioremediation - Active and Passive Approaches"},signatures:"Cleide S. T. Araújo, Dayene C. Carvalho, Helen C. Rezende, Ione L. S.\nAlmeida, Luciana M. Coelho, Nívia M. M. Coelho, Thiago L. Marques\nand Vanessa N. Alves",authors:[{id:"163731",title:"Prof.",name:"Nivia",middleName:null,surname:"Coelho",slug:"nivia-coelho",fullName:"Nivia Coelho"}]},{id:"45279",doi:"10.5772/56418",title:"Persistence and Bioaccumulation of Persistent Organic Pollutants (POPs)",slug:"persistence-and-bioaccumulation-of-persistent-organic-pollutants-pops-",totalDownloads:4527,totalCrossrefCites:16,totalDimensionsCites:30,abstract:null,book:{id:"3547",slug:"applied-bioremediation-active-and-passive-approaches",title:"Applied Bioremediation",fullTitle:"Applied Bioremediation - Active and Passive Approaches"},signatures:"Tomaz Langenbach",authors:[{id:"100969",title:"Dr.",name:"Tomaz",middleName:null,surname:"Langenbach",slug:"tomaz-langenbach",fullName:"Tomaz Langenbach"}]},{id:"45726",doi:"10.5772/56905",title:"Rhizoremediation: A Promising Rhizosphere Technology",slug:"rhizoremediation-a-promising-rhizosphere-technology",totalDownloads:3007,totalCrossrefCites:9,totalDimensionsCites:26,abstract:null,book:{id:"3547",slug:"applied-bioremediation-active-and-passive-approaches",title:"Applied Bioremediation",fullTitle:"Applied Bioremediation - Active and Passive Approaches"},signatures:"Keshav Prasad Shukla, Shivesh Sharma, Nand Kumar Singh,\nVasudha Singh, Sandeep Bisht and Vivek Kumar",authors:[{id:"164650",title:"Dr.",name:"Shivesh",middleName:null,surname:"Sharma",slug:"shivesh-sharma",fullName:"Shivesh Sharma"}]},{id:"52211",doi:"10.5772/64940",title:"Cyanobacterial Toxins Emerging Contaminants in Soils: A Review of Sources, Fate and Impacts on Ecosystems, Plants and Animal and Human Health",slug:"cyanobacterial-toxins-emerging-contaminants-in-soils-a-review-of-sources-fate-and-impacts-on-ecosyst",totalDownloads:4326,totalCrossrefCites:6,totalDimensionsCites:23,abstract:"In the last few decades, there has been a growing interest in the occurrence of cyanotoxins and their potential toxicity in the aquatic environment. However, the used of dried toxic cyanobacteria cells as fertilizer or the used of surface water contaminated with cyanotoxins for agricultural crops irrigation can be source of soil contamination. In addition, surface waters presenting dense toxic blooms of cyanobacteria and used for agricultural practices are not controlled and are often used without prior treatment. Once in soil, cyanotoxins may be transported again to water bodies by leaching, runoff and drainage processes or can be accumulated in soils and, therefore, may cause contamination of vegetation by absorption from soils or by surface pollution of plants. In addition to possible effects on human health, elevated levels of cyanotoxins in soils can negatively affect plant vigour, animal health, microbial processes and overall soil health. Consequently, the focus of this chapter of soil contamination is cyanotoxins as contaminants of emerging concern in the soil, identifying sources of contamination, determining their fate and effects in the soil, and understanding their bioaccumulation in agricultural plants used for feed and food and consequences on animal and human health.",book:{id:"5358",slug:"soil-contamination-current-consequences-and-further-solutions",title:"Soil Contamination",fullTitle:"Soil Contamination - Current Consequences and Further Solutions"},signatures:"Noureddine Bouaïcha and Sylvain Corbel",authors:[{id:"186021",title:"Dr.",name:"Noureddine",middleName:null,surname:"Bouaïcha",slug:"noureddine-bouaicha",fullName:"Noureddine Bouaïcha"},{id:"186034",title:"Dr.",name:"Sylvain",middleName:null,surname:"Corbel",slug:"sylvain-corbel",fullName:"Sylvain Corbel"}]},{id:"45263",doi:"10.5772/56372",title:"Biodegradation of the Organophosphate Pesticide Profenofos by Marine Fungi",slug:"biodegradation-of-the-organophosphate-pesticide-profenofos-by-marine-fungi",totalDownloads:3916,totalCrossrefCites:8,totalDimensionsCites:20,abstract:null,book:{id:"3547",slug:"applied-bioremediation-active-and-passive-approaches",title:"Applied Bioremediation",fullTitle:"Applied Bioremediation - Active and Passive Approaches"},signatures:"Natália Alvarenga da Silva, Willian Garcia Birolli, Mirna Helena Regali Seleghim and André Luiz Meleiro Porto",authors:[{id:"29131",title:"Prof.",name:"André",middleName:null,surname:"LM Porto",slug:"andre-lm-porto",fullName:"André LM Porto"},{id:"164743",title:"Ms.",name:"Natália Alvarenga",middleName:null,surname:"Da Silva",slug:"natalia-alvarenga-da-silva",fullName:"Natália Alvarenga Da Silva"},{id:"164744",title:"Prof.",name:"Mirna Helena R.",middleName:null,surname:"Seleghim",slug:"mirna-helena-r.-seleghim",fullName:"Mirna Helena R. Seleghim"}]}],mostDownloadedChaptersLast30Days:[{id:"52054",title:"Radioactive Contamination of the Soil: Assessments of Pollutants Mobility with Implication to Remediation Strategies",slug:"radioactive-contamination-of-the-soil-assessments-of-pollutants-mobility-with-implication-to-remedia",totalDownloads:8601,totalCrossrefCites:9,totalDimensionsCites:15,abstract:"Accidental releases, nuclear weapons testing, and inadequate practices of radioactive waste disposal are the principal human activities responsible for radioactive contamination as a new and global form of soil degradation. Understanding the radionuclide distribution, mobility and bioavailability, as well as the changes caused by the variation of environmental conditions, is essential for soil rehabilitation. This chapter aims to highlight the importance of evaluating radionuclide distribution, for the selection of proper in situ or ex situ remediation strategy. Attention was focused onto remediation methods based on radioactive pollutants redistribution, for enhanced separation (chemical extraction) or containment (in situ immobilization). When the excavation and off-site leaching treatments are uneconomic, impractical, or unnecessary, in situ stabilization by the addition of appropriate reactive materials is an alternative approach. The optimization of factors in control of chemical leaching methods, selection of cost-effective immobilization agents, especially among suitable wastes and by-products, and verification of long-term effects of remediating actions are the major challenges for future investigation in this field. Furthermore, the improvement and standardization of the methods for radionuclide speciation are necessary to enable comparison between studies and monitoring of the effects achieved by the soil treatments.",book:{id:"5358",slug:"soil-contamination-current-consequences-and-further-solutions",title:"Soil Contamination",fullTitle:"Soil Contamination - Current Consequences and Further Solutions"},signatures:"Ivana Smičiklas and Marija Šljivić-Ivanović",authors:[{id:"186699",title:"Ph.D.",name:"Marija",middleName:null,surname:"Sljivic-Ivanovic",slug:"marija-sljivic-ivanovic",fullName:"Marija Sljivic-Ivanovic"},{id:"186801",title:"Dr.",name:"Ivana",middleName:null,surname:"Smičiklas",slug:"ivana-smiciklas",fullName:"Ivana Smičiklas"}]},{id:"62735",title:"Peat Use in Horticulture",slug:"peat-use-in-horticulture",totalDownloads:1570,totalCrossrefCites:6,totalDimensionsCites:8,abstract:"Peat is a spongy substance which is an effect of incomplete decomposition of plant residues in different stages of decomposition. Between the several organic matters which are used as substrate for horticultural plants cultivation in soilless conditions, peat is the unabandonable ingredient for mixtures for commercial production of plants. Peat is used in horticulture as a component of garden plant substrates, in agriculture for the production of garden soil and as an organic fertilizer, and in balneology as a material for baths and wraps. The use of peat for agriculture and horticulture is determined by the following quality parameters: the degree of decomposition, ash content, pH, the presence of carbonates, the density of the solid phase, bulk density, and porosity. As an organic material, the peat forms in the acidic, waterlogged, and sterile conditions of fens and bogs. The conditions seem like the development of mosses. The plants do not compose as they die. Instead of this, the organic matter is laid down and accumulates in a slow time as peat due to the oxygen deficiency in the bog. This makes peat a highly productive growing medium. In the present novel review, we discuss the peat use in horticulture.",book:{id:"6316",slug:"peat",title:"Peat",fullTitle:"Peat"},signatures:"Nurgul Kitir, Ertan Yildirim, Üstün Şahin, Metin Turan, Melek Ekinci,\nSelda Ors, Raziye Kul, Hüsnü Ünlü and Halime Ünlü",authors:[{id:"140612",title:"Prof.",name:"Metin",middleName:null,surname:"Turan",slug:"metin-turan",fullName:"Metin Turan"},{id:"186637",title:"Dr.",name:"Nurgül",middleName:null,surname:"Kıtır",slug:"nurgul-kitir",fullName:"Nurgül Kıtır"},{id:"186639",title:"Prof.",name:"Ertan",middleName:null,surname:"Yildirim",slug:"ertan-yildirim",fullName:"Ertan Yildirim"},{id:"247120",title:"Prof.",name:"Melek",middleName:null,surname:"Ekinci",slug:"melek-ekinci",fullName:"Melek Ekinci"},{id:"247121",title:"Prof.",name:"Selda",middleName:null,surname:"Ors",slug:"selda-ors",fullName:"Selda Ors"},{id:"247122",title:"MSc.",name:"Raziye",middleName:null,surname:"Kul",slug:"raziye-kul",fullName:"Raziye Kul"},{id:"247123",title:"Prof.",name:"Ustun",middleName:null,surname:"Sahin",slug:"ustun-sahin",fullName:"Ustun Sahin"},{id:"260571",title:"Prof.",name:"Hüsnü",middleName:null,surname:"Ünlü",slug:"husnu-unlu",fullName:"Hüsnü Ünlü"},{id:"260572",title:"Dr.",name:"Halime",middleName:null,surname:"Ünlü",slug:"halime-unlu",fullName:"Halime Ünlü"}]},{id:"59383",title:"The Status of Pachiterric Histosol Properties as Influenced by Different Land Use",slug:"the-status-of-pachiterric-histosol-properties-as-influenced-by-different-land-use",totalDownloads:1335,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"Soil drainage as well as soil cultivation and fertilization has considerable influence on the organic matter mineralization rate and changes in the profile structure. Our research suggested that quantitative and qualitative characteristics of peat soil are changing in response to the renaturalization processes and different management. The study set out to estimate chemical and physical properties of Pachiterric Histosol, qualitative and quantitative changes in carbon resulting from different management and renaturalization processes. Wetland and peatland soils are among the largest organic carbon stocks, and their use contributes to carbon emissions or accumulation processes. The focus of our work is research into the peculiarities of organic carbon accumulation and transformation as influenced by different land use of peat soil. Results on the chemical properties of Pachiterric Histosol showed the influence of management and renaturalization on mobile and by pyrophosphate solution extractable humic and fulvic acids and humification degree. We are also exploring the specificities of organic carbon variation in the context of peat renaturalization and are seeking to answer the question as how to optimize the use of peat soils and how to match up this with the renaturalization processes in order to reduce greenhouse gas emissions and contribute to organic carbon accumulation and conservation in the soil.",book:{id:"6316",slug:"peat",title:"Peat",fullTitle:"Peat"},signatures:"Alvyra Slepetiene, Kristina Amaleviciute-Volunge, Jonas Slepetys,\nInga Liaudanskiene and Jonas Volungevicius",authors:[{id:"211107",title:"Dr.",name:"Alvyra",middleName:null,surname:"Slepetiene",slug:"alvyra-slepetiene",fullName:"Alvyra Slepetiene"},{id:"211216",title:"Dr.",name:"Kristina",middleName:null,surname:"Amaleviciute",slug:"kristina-amaleviciute",fullName:"Kristina Amaleviciute"},{id:"211217",title:"Dr.",name:"Jonas",middleName:null,surname:"Slepetys",slug:"jonas-slepetys",fullName:"Jonas Slepetys"},{id:"211219",title:"Dr.",name:"Inga",middleName:null,surname:"Liaudanskiene",slug:"inga-liaudanskiene",fullName:"Inga Liaudanskiene"},{id:"211221",title:"Dr.",name:"Jonas",middleName:null,surname:"Volungevicius",slug:"jonas-volungevicius",fullName:"Jonas Volungevicius"}]},{id:"71992",title:"Biochar-Assisted Wastewater Treatment and Waste Valorization",slug:"biochar-assisted-wastewater-treatment-and-waste-valorization",totalDownloads:1225,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"Biochar is the solid byproduct of pyrolysis, and its cascading use can offset the cost of the production and its use in application such as soil remediation. A wide variety of research on biochar has highlighted its ability to absorb nutrients, metal and complex compounds, filter suspended solids, enhance microorganisms’ growth, retain water and nutrients as well as increasing the carbon content of the soil. Besides, sustainable biochar systems are an attractive approach for carbon sequestration and total waste management cycle. The chapter looks into such cascading use of biochar in wastewater treatment for recovering nutrients and improving the efficiency of activated sludge treatment and anaerobic digestion for producing biosolid with enhanced soil amendment properties.",book:{id:"10005",slug:"applications-of-biochar-for-environmental-safety",title:"Applications of Biochar for Environmental Safety",fullTitle:"Applications of Biochar for Environmental Safety"},signatures:"Abhishek Pokharel, Bishnu Acharya and Aitazaz Farooque",authors:[{id:"317504",title:"Associate Prof.",name:"Bishnu",middleName:null,surname:"Acharya",slug:"bishnu-acharya",fullName:"Bishnu Acharya"},{id:"317505",title:"Mr.",name:"Abhishek",middleName:null,surname:"Pokharel",slug:"abhishek-pokharel",fullName:"Abhishek Pokharel"},{id:"317506",title:"Dr.",name:"Aitazaz",middleName:null,surname:"Farooque",slug:"aitazaz-farooque",fullName:"Aitazaz Farooque"}]},{id:"62866",title:"Introductory Chapter: Introduction to Peat",slug:"introductory-chapter-introduction-to-peat",totalDownloads:1029,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"6316",slug:"peat",title:"Peat",fullTitle:"Peat"},signatures:"Bülent Topcuoğlu and Metin Turan",authors:[{id:"194133",title:"Prof.",name:"Bülent",middleName:null,surname:"Topcuoğlu",slug:"bulent-topcuoglu",fullName:"Bülent Topcuoğlu"}]}],onlineFirstChaptersFilter:{topicId:"142",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:17,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:301,paginationItems:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"322007",title:"Dr.",name:"Maria Elizbeth",middleName:null,surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",country:{name:"Mexico"}}},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. 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Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. 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