Candidate genes for preferable altering the cell wall polymers (cellulose, hemicellulose and lignin) in plant system.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5613",leadTitle:null,fullTitle:"Depression",title:"Depression",subtitle:null,reviewType:"peer-reviewed",abstract:"Depressive disorders can be seen as a disturbance to the balance of mind and body. Because it is a mental disorder and psychiatry is a branch of medicine, the question how mind and body interact in depression should be treated as a medical rather than metaphysical mind-body problem. The relation between mind and body as it pertains to this illness should be construed in teleological rather than causal terms. Mental states like beliefs and emotions serve an adaptive purpose by constraining the physiologic systems involved in the body's stress response, thus preserving homeostasis and protecting us from various disorders. Depression results when the mind fails its constraining role.",isbn:"978-953-51-3060-4",printIsbn:"978-953-51-3059-8",pdfIsbn:"978-953-51-4891-3",doi:"10.5772/63698",price:119,priceEur:129,priceUsd:155,slug:"depression",numberOfPages:110,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"55a9dc35540a109935252f1cdae88e83",bookSignature:"Dagmar Breznoščáková",publishedDate:"March 29th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5613.jpg",numberOfDownloads:10257,numberOfWosCitations:6,numberOfCrossrefCitations:8,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:13,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:27,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 2nd 2016",dateEndSecondStepPublish:"June 23rd 2016",dateEndThirdStepPublish:"September 19th 2016",dateEndFourthStepPublish:"December 18th 2016",dateEndFifthStepPublish:"February 16th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"99961",title:"Dr.",name:"Dagmar",middleName:null,surname:"Breznoscakova",slug:"dagmar-breznoscakova",fullName:"Dagmar Breznoscakova",profilePictureURL:"https://mts.intechopen.com/storage/users/99961/images/5320_n.png",biography:"Since 2016, Dagmar Breznoščáková, MD, PhD, has been the vice-president of Slovak Psychiatric Association and CPT member of the Council of Europe with respect to Slovak Republic. Since 2012, she has been the chairwoman of the Section of Psychopharmacology Slovak Psychiatric Association, Slovak Medical Association. In 2006, she was registered in the List of Experts of the Ministry of Justice SR and has since worked as an expert witness in psychiatry. Since 2006, she has also been engaging in private outpatient psychiatric care and psychotherapy. She successfully completed a 4.5-year European training in cognitive behavioral psychotherapy and completed her postgraduate studies at the Masaryk University in Brno, Czech Republic. The topic of her postgraduate study was “Carbohydrate Metabolism and Depression.” After graduation, she started to work as a resident at the Department of Psychiatry, Faculty of Medicine, UPJŠ, and Faculty Hospital in Košice. Since 2005, she has been working as an assistant professor at the Faculty of Medicine, Faculty of Law and Philosophy UPJŠ in Košice. She also lectures and publishes in her field, focusing on affective and anxiety disorders, particularly bipolar disorder, comorbidity of mental disorders, and psychosomatic connections. She is a coauthor of several chapters in foreign as well as domestic publications and author of psychoeducational handbooks for patients and their relatives, all in all over 150 publication outputs. She holds prizes for the best original work for the journal of psychiatry practice and figures in the biographical encyclopedia of Slovak republic personalities Who Is Who. She organizes and actively participates in various psychoeducational and antistigma activities and is the chairwoman of ROZ ODOS Košice o. z., joining together patients, their relatives, professionals, as well as the general public or supporters.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Pavol Jozef Šafárik",institutionURL:null,country:{name:"Slovakia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1057",title:"Neuropsychiatry",slug:"neuropsychiatry"}],chapters:[{id:"54006",title:"Clock Genes in Depression",doi:"10.5772/67261",slug:"clock-genes-in-depression",totalDownloads:1525,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Data demonstrate that abnormal regulation of the circadian system can result in cardiovascular disease, metabolic syndrome, obesity, immune dysfunction, increased risk for cancer, reproductive complications, etc. It is highly individual among depressed patients and may be expressed as a phase advance or phase delay of rhythms and/or increase or decrease in the amplitude. The stress-induced anhedonic-like state characterizes by hypothermia, hypercortisolemia, and hypermelatoninemia associated with disturbances in the circadian system. Mainly Per2 and Bmal1 demonstrate altered expression in the brain and liver: expression of Per2 is sensitive to stress and changes in Bmal1 mostly associated with depressive behavior. The Per1 expression is sustainable in maintaining the circadian rhythm. A normalization of the expression patterns is likely to be essential for the recovery from the pathological state. Depression is a high prevalent disorder. The number of incidents is rising due to changes in lifestyle. The symptomatology is inconsistent and it is difficult to agree on one hypothesis. The disturbances of the 24 h circadian rhythm may be a factor in the development of major depressive disorder. The molecular biology underlying a causal relationship between circadian rhythm and mood disorders is slowly being unraveled. However, many questions still need to be answered.",signatures:"Sofie Laage Christiansen and Elena V. Bouzinova",downloadPdfUrl:"/chapter/pdf-download/54006",previewPdfUrl:"/chapter/pdf-preview/54006",authors:[{id:"193626",title:"Ph.D.",name:"Elena V.",surname:"Bouzinova",slug:"elena-v.-bouzinova",fullName:"Elena V. Bouzinova"},{id:"203327",title:"Dr.",name:"Sofie",surname:"Laage Christiansen",slug:"sofie-laage-christiansen",fullName:"Sofie Laage Christiansen"}],corrections:null},{id:"54141",title:"Brain Lateralization of Emotional Processing in Depression",doi:"10.5772/66828",slug:"brain-lateralization-of-emotional-processing-in-depression",totalDownloads:1858,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:1,abstract:"There are three major hypotheses regarding the lateralization of emotion in the brain—the right-hemisphere hypothesis (RHH), the valence hypothesis, and the approach-withdrawal hypothesis. The approach-withdrawal hypothesis, which is the most widely accepted, states that emotions that elicit approach behaviors are lateralized to the left hemisphere, while emotions that elicit withdrawal behaviors are lateralized to the right hemisphere. In line with this hypothesis, it has been found that persons with depression show left frontal hypoactivity and right frontal hyperactivity. This hemispheric asymmetry appears not to influence mood but rather emotional reactions to affective stimuli. That is, a person with such an asymmetry does not show a predominant negative mood, but rather heightened negative reactions to occurrences in the environment. The asymmetry may also be a biological marker of depression, with research evidence that it is found in remitted depressives and in infants of depressed mothers. Currently, research in this area focuses on identifying the mechanism underlying the link between the asymmetry and depression.",signatures:"Danielle M. Pereira and Azizuddin Khan",downloadPdfUrl:"/chapter/pdf-download/54141",previewPdfUrl:"/chapter/pdf-preview/54141",authors:[{id:"193068",title:"Associate Prof.",name:"Azizuddin",surname:"Khan",slug:"azizuddin-khan",fullName:"Azizuddin Khan"},{id:"194237",title:"Ms.",name:"Danielle",surname:"Danielle Pereira",slug:"danielle-danielle-pereira",fullName:"Danielle Danielle Pereira"}],corrections:null},{id:"53855",title:"Anxiety and Depression in Cardiovascular Surgery",doi:"10.5772/67064",slug:"anxiety-and-depression-in-cardiovascular-surgery",totalDownloads:1418,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Although anxiety and depression are psychological risk factors for coronary artery disease (CAD), psychological aspect in patients with cardiovascular surgery has been less considered. Cognitive and psychological deficit has been still concerning in spite of notable improvement of cardiovascular surgery using cardiopulmonary bypass perfusion. The purpose of this chapter review is to discuss recent data concerning the prevalence and trend of anxiety and depression of patients with cardiovascular surgery and to introduce the nonpharmacological intervention studies. The prevalence of anxiety and depression of patients after cardiovascular surgeries has varied from 10 to 60% and has been likely higher than that of general people. From the limited studies about patients over 6 months after surgery, we guessed the followings about the trends of anxiety and depression of patients with CABG without any other additional intervention programs before/after surgery: (1) patients improved scores of anxiety and depression 3–6 months after surgery, (2) anxiety decreased considerably for about 6 months after CABG and then leveled out for some time, (3) depression remained a bit higher 6 months and more after CABG. Patients’ longitudinal psychological conditions would have been influenced by not only invasive cardiovascular surgery but also life events. The nonpharmacology intervention would have improved patients’ psychological conditions. Further research is needed to clarify the long-term psychological outcome and to develop the effective intervention programs toward patients with cardiovascular surgery.",signatures:"Yuko Okamoto and Noboru Motomura",downloadPdfUrl:"/chapter/pdf-download/53855",previewPdfUrl:"/chapter/pdf-preview/53855",authors:[{id:"49017",title:"Prof.",name:"Noboru",surname:"Motomura",slug:"noboru-motomura",fullName:"Noboru Motomura"},{id:"193513",title:"Dr.",name:"Yuko",surname:"Okamoto",slug:"yuko-okamoto",fullName:"Yuko Okamoto"}],corrections:null},{id:"53777",title:"Chronic Pain and Depression",doi:"10.5772/66671",slug:"chronic-pain-and-depression",totalDownloads:2370,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Today, it is clear that chronic pain and depression are closely related. Depression can cause pain, and chronic pain can cause depression too. According to the American Pain Foundation, about 32 million people in the U.S. report have had pain lasting longer than 1 year. Statistical international data prove that more than half of the patients with pain are depressed or have mood swings, and on average, 65% of depressed people also complain of pain. Patients simultaneously suffering of chronic pain and limited independence are especially vulnerable. Fibromyalgia (FM) is one of the most common chronic pain syndromes, affecting 15 up to 5% of world population, is characterized as diffuse widespread body pain, with definite tender points and clinical features, and also triggers the development of depression. Depression severity in patients with FM worsens severity of pain. Depressive disorders are observed in approximately 90% of patients with FM. Pain triggers development of depressive conditions in patients with chronic character of pain, and time course of disease shows certain pattern of increasing of severity of depression and worsens long term outcomes. Patients with chronic pain must be evaluated for depression, and successful management of pain must include treatment of depressive mood too.",signatures:"Aleksandra A. Karapetyan and Hovhannes M. Manvelyan",downloadPdfUrl:"/chapter/pdf-download/53777",previewPdfUrl:"/chapter/pdf-preview/53777",authors:[{id:"71210",title:"Prof.",name:"Hovhannes",surname:"Manvelyan",slug:"hovhannes-manvelyan",fullName:"Hovhannes Manvelyan"},{id:"193854",title:"Dr.",name:"Aleksandra",surname:"Karapetyan",slug:"aleksandra-karapetyan",fullName:"Aleksandra Karapetyan"}],corrections:null},{id:"53680",title:"Investigating the Relationship between Depression, Negative Automatic Thoughts, Life Satisfaction and Symptom Interpretation in Turkish Young Adults",doi:"10.5772/66622",slug:"investigating-the-relationship-between-depression-negative-automatic-thoughts-life-satisfaction-and-",totalDownloads:1680,totalCrossrefCites:4,totalDimensionsCites:6,hasAltmetrics:0,abstract:"The purpose of this study is to examine the relationship between depression, negative automatic thoughts, life satisfaction, number of symptoms, psychologizing, somatizing and normalizing in young adults. The mediator role of life satisfaction in the relationship between negative automatic thoughts and depression especially is the major question of this study. Participants are composed of 115 volunteer teacher candidates from an urban Turkish university. Their ages vary between 21 and 29. The data are collected through Beck Depression Inventory, Life Satisfaction Scale, Automatic Thoughts Scale, Symptom Interpretation Questionnaire and Personal Information Form. As a result, it is seen that the depression scores of young adults do not differ according to gender and according to whether they encountered an event causing stress in the past 3 months or not. Another finding is that five variables (negative automatic thoughts, life satisfaction, number of symptoms, psychologizing and normalizing) are significant predictors in explaining the depression level of young adults. Together, these five variables explain 52% of the young adults’ depression. Another finding of the study is that negative automatic thoughts of young adults make them negatively assess quality of life and this causes the depression levels to increase.",signatures:"Yasemin Yavuzer and Zeynep Karataş",downloadPdfUrl:"/chapter/pdf-download/53680",previewPdfUrl:"/chapter/pdf-preview/53680",authors:[{id:"193985",title:"Associate Prof.",name:"Yasemin",surname:"Yavuzer",slug:"yasemin-yavuzer",fullName:"Yasemin Yavuzer"},{id:"196063",title:"Dr.",name:"Zeynep",surname:"Karataş",slug:"zeynep-karatas",fullName:"Zeynep Karataş"}],corrections:null},{id:"53669",title:"Body-Mind Connectedness: Integrative Body-Mind-Spirit Group Work for Depressed Persons with Salient Somatic Disturbances",doi:"10.5772/66960",slug:"body-mind-connectedness-integrative-body-mind-spirit-group-work-for-depressed-persons-with-salient-s",totalDownloads:1406,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Globally, depression frequently comorbid with a variety of physical illnesses, which exert substantial mental and somatic distresses on patients. Sleep disturbance is one of the common conditions reported by individuals with either, mental or physical illnesses. Complex interaction among depression, sleep and physical illnesses highlighted the essential mind‐body connection in the planning of integrative care and other clinical services. A number of eastern mind‐body practices, such as Qigong, acupuncture and meditation, have been frequently studied indicating the efficacy of mind‐body connection in complementary therapies. This chapter will introduce the integrative body‐mind‐spirit (I‐BMS) group work, which has been found effective in addressing comorbid depressed mood and somatic afflictions, especially sleep disturbances among Hong Kong Chinese adults.",signatures:"Sylvia Hong Yao, Jane Xiao-Wen Ji, Celia Hoi Yan Chan and Cecilia\nLai Wan Chan",downloadPdfUrl:"/chapter/pdf-download/53669",previewPdfUrl:"/chapter/pdf-preview/53669",authors:[{id:"194033",title:"Ms.",name:"Hong",surname:"Yao",slug:"hong-yao",fullName:"Hong Yao"},{id:"194041",title:"Ms.",name:"Xiaowen",surname:"Ji",slug:"xiaowen-ji",fullName:"Xiaowen Ji"},{id:"194042",title:"Prof.",name:"Lai Wan",surname:"Chan",slug:"lai-wan-chan",fullName:"Lai Wan Chan"},{id:"195960",title:"Dr.",name:"Celia Hoi Yan",surname:"Chan",slug:"celia-hoi-yan-chan",fullName:"Celia Hoi Yan Chan"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited 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Production of biofuel also called as ‘green energy’ will be a key target to achieve this by reducing the use of petrochemicals. Now focus is to harness ethanol from the existing ample quantity of lignocellulosic feedstocks such as rice and wheat straws, which are usually burnt in the fields thereby causing air pollution and health hazards [1]. The bioenergy crops have tremendous potential to address the twin issues of climate change and energy security by eliminating the ‘food verses fuel’ disputes.
Of the various crops grown worldwide, rice has an immense potential to be used as a dual-purpose crop, due to it’s wide geographical distribution, covering entire tropical, subtropical and Mediterranean region of the globe [2]. High amount of cellulose (32–47%) and hemicellulose (19–27%) in rice straw, which can be converted to biofuel, has made it a potential future bioenergy crop [3, 4, 5, 6]. But the cell wall polymers (cellulose, hemicellulose and lignin) form a complex network by crosslinking with each other. Hence, various pre-treatments are employed in order to break this complex to ensure higher amount of cellulose availability for the activity of cellulosic enzymes to yield considerable sugars. These pre-treatments are costly and environment unfriendly, so various genetic approaches can be utilised to enhance cellulose availability. Lignin, comprising three main types of monolignols, serves as a promising target to alter the cell wall architecture in different ways in rice [7, 8, 9]. Cellulose synthases genes particularly, OsCesA4, OsCesA7 and OsCesA9, associating with specific phenotypes, can also be suitably engineered to enhance cellulose content without changing lignin and other polymers in cell wall [10]. So, breeding approaches that can alter plant cell wall architecture can be used to develop bioenergy efficient rice variety but, subjected to one condition that it should not affect yield contributing traits negatively.
Usually, a negative correlation has been observed between grain yield and biomass traits. Breeding for high grain yield is associated with developing cultivars with reduced plant height and short leaves and thereby, reducing the plant biomass as a whole. The plant breeding strategies have to be reoriented towards selection of higher yielding plants with moderate biomass traits including lesser ash & potassium content in vegetative biomass. Also, the role of stay green traits, fostering greater decomposition of vegetative biomass as well as rewarding higher yield, can never be underestimated in this regard. This chapter will deal with the above said issues and measures, with the prime focus on methods for developing rice genotypes for higher yield and greater biofuel production, in subsequent heads.
Ethanol production is primarily centered around the lignocellulosic fraction of the plant biomass. Among all the left-over waste of crop species, rice straw is the cheapest and most abundant source of lignocellulosic feed stock. Rice straw, possessing considerable amount of cellulose (32–47%), hemicellulose (19–27%), with relatively less lignin (5–24%), is considered as one of the potent bioenergy sources [3, 5]. Various enzymes have been identified in the biosynthesis of these polymers (Figures 1–3) which determine the type and amount of polymer production in the plant cells. The cell wall polymers form a complex network by crosslinking with each other inside the cell walls. Hence, various pre-treatments are employed in order to break these complexes, to reduce crystallinity of cellulose (crt), degree of polymerisation (DP), increase in biomass surface area, and breaking the lignin seal. Chemical pre-treatment of rice straw is practiced to enable enzymatic saccharification for ethanol production [13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26].
Cellulose biosynthesis pathway in microbes and plants.
Hemicellulose monomer biosynthesis pathway.
Lignin biosynthesis pathways. The various enzymes are PAL [phenylalanine ammonia-lyase]; TAL [tyrosine ammonia-lyase]; C4H [cinnamate 4-hydroxylase]; C3H [4-hydroxycinnamate 3-hydroxylase]; COMT [caffeic acid 3-O- methyltransferase]; F5H [ferulate 5-hydroxylase]; 4CL [4-coumarate: CoA ligase]; CCoA-3H [coumaroyl-CoA 3-hydroxylase]; CCoAOMT [caffeoyl-CoA O-methyltransferase]; CCR [cinnamoyl-CoA reductase]; CAD [cinnamyl alcohol dehydrogenase]; LAC [laccase]; and PDX [peroxidase] (modified from Furtado et al. [
Biological pretreatment, an eco-friendly method, overcomes the disadvantages of chemical pretreatment. White-rot fungi (
Cellulose contain glucans while hemicellulose is composed of polymers of xylan, mannan, glucan, galactan and arabinan. The general process of ethanol production involves conversion of cellobiose to ethanol by a series of steps of involving pre-treatment, enzymatic saccharification and fermentation as described earlier. These steps may include simultaneous saccharification and fermentation (SSF) or separate enzymatic hydrolysis and fermentation (SHF). SSF is generally used as cost incurred in the process is less [33]. In this process also, higher yield of ethanol is obtained. However, some drawbacks are observed in this process such as requirement of optimum temperature (40-50°C) for enzymatic hydrolysis, which the microorganisms cannot tolerate. This problem can be tackled by using thermophilic microorganisms such as
These chemical processes for saccharification are harmful to the environment. Hence now research should be focused towards minimising or eliminating these steps by developing rice genotypes with higher saccharification efficiency (SE).
As mentioned earlier the lignocellulosic biomass is primarily a complex network of various cellular constituents including cellulose, hemicellulose, lignin and interaction of a wide array of compounds like chlorophyll, waxes, oils, terpenes and phenolics, called extractives [38, 39]. It is beneficial to have knowledge on the genetics as well as correlation between biomass traits and these cellular constituents. A greater insight into the composition, structure and the synthesis of cellular constituents will help in designing suitable breeding strategies for the genetic modification of cell wall architecture and in turn development of high energy efficient rice genotypes.
In simple term, it refers to the study of various morphological, physiological, biochemical traits, associated with grain and biomass yield. Rigorous phenotyping is essential for the success of any crop improvement programme. In breeding for biofuel, although some noticeable work has been done in case of bioenergy crops like sorghum, maize and sugarcane, very limited information is available with respect to rice, which is considered as a hinderance in effective phenotyping in this regard.
It is reported that culm length, stem girth, tiller length and diameter, leaf characteristics such as leaf length, width and angle as well as leaf, stem, tiller dry weight are few key biomass traits that can be used for indirect selection [40, 41]. These traits recorded at different developmental stages will help to decipher the genetic basis of biomass partitioning and accumulation in vegetative parts.
Biochemical characterisation of rice straw cell wall polymers (cellulose, lignin and hemicellulose) is an integral part of biomass phenotyping. Many methods like use of ultrasonicator, HPLC, microarrays, Infrared absorption spectroscopy, X- ray diffraction (XRD), transmission electron microscopy (TEM) and carbon-13 nuclear magnetic resonance (C-NMR) spectroscopy can be used for quantitative estimation of cell wall polymers [42, 43].
Cellulose is the utmost abundant organic compound available on earth. It is a linear polymer of repeating units of cellobiose molecule. Cellobiose, a β (1–4)-linked residue, is produced when two glucose molecules (one in 180 deg. rotation) are in proximity to yield a β (1–4)-linkage. These cellulose fibres impart a greater rigidity and strength to the cell wall and hence, enabling plants to exhibit a wide spectrum resistance to various biotic and abiotic factors [12]. The non-cellulosic polysaccharides further enhance the rigidity and strength of plant cell walls by cross-linking with cellulose and lignin. Various reports have suggested this cellular constituent as a mixture of various monosaccharides such as xylose, arabinose, glucose, galactose and rhamnose as well as certain acids [44, 45]. This complex nature of non-cellulosic polysaccharides as well as their involvement in cross linking with cellulose, possesses a major setback in the efficient enzymatic degradation of cellulose to produce biofuel.
Lignin, the second most abundant biopolymer after cellulose, is polymerised with three main types of monolignols namely, Syringyl alcohol (S), Coniferyl alcohol (H) and p-Coumaryl alcohol (H) [46, 47]. As a complex phenolic compound, it improves cell wall rigidity and strength, imparts resistance to a wide array of microbes [48], fosters transporting of minerals through vascular bundles [49], involves in resistance against lodging as well as abiotic anomalies [50, 51, 52].
Cellulose and hemicellulose in rice straw can be subjected to fermentation for production of biofuels. However, their efficient conversion into fermentable sugars is hindered by presence of higher amount of lignin (5–24%), ash (10–17%), silica (75% of ash) and potassium [53].
In rice, silica comprises 74.67% of the stem ash content. Both high ash and high silica (SiO2) silica content of ash negatively affect biochemical conversion of lignocellulosic feedstock [11, 53]. High silica content reduces the availability of cellulose to enzymatic digestion and thus, reducing saccharification efficiency. Besides this, high silica accumulation in the cell walls disrupts the cellulosic microfibrils and such aberration hinders overall sugar release and ultimately, ethanol yields in subsequent stages. Therefore, considerable efforts are required to engineer silica content along with lignin and non-carbohydrate polysaccharides content to develop rice genotypes, amenable to greater enzymatic digestibility.
Although, different enzymatic and chemical pre-treatment methods are being employed for the disruption of this complex network but these procedures are energy intensive, costly and harmful to the environment. Hence, genetically modifying the cell wall architecture by employing conventional and modern breeding methods are beneficial for sustainable biofuel production [11, 54].
As discussed earlier, lignin serves as a key element in cross linking of cellulose and hemicellulosic polysaccharides. This feature is beneficial to the rice plant as it helps it to counteract biotic and abiotic stress but it is a limiting feature for biofuel production. The cross linking creates a barrier for the cellulose degrading enzymes to freely access cellulose for conversion. So, efforts are being made towards reducing the degree of lignification and cross linking through various approaches so as to enhance the efficiency of cellulose degrading enzymes.
Some noticeable work has been done to alter the plant cell wall architecture with the help of biotechnology in model dicot plants such as Arabidopsis and tobacco (Table 1). The purpose behind these experiments has been the downregulation of key genes involved in monolignol biosynthesis, as well as the essential enzymes involving in polymerisation thereof. Nearly 40% reduction in total lignin content was achieved by downregulating laccases and peroxidases in the Arabidopsis [61] and tobacco mutants [62], respectively. So, these available reports documenting successful reduction of lignin composition in model dicot plants can be judiciously used by the researchers to favourably alter the cell wall architecture of the less exploited prospective biofuel crops such as rice. The
Cell wall polymer regulation | Genes | Approach | Phenotypes | Reference(s) |
---|---|---|---|---|
Cellulose synthesis | Bc11 (G858R), NE1031, ND5658 (TOS17) | Reduce cellulose; affect growth | [10] | |
NC0258, ND8759 (TOS17) | Reduce cellulose; affect growth | [10] | ||
ND2359 (TOS17) | Reduce cellulose; affect growth | [10] | ||
Osfc4; Osfc11 (T-DNA) | Reduced Cr1(Cellulose crystallinity) | [55] | ||
pCAMBIAI11300: | Reduced Cr1; DP (Degree of Polymerisation) | [56] | ||
F2 (fc17 × MH 63) | Reduced Cr1 | [57] | ||
Cellulose regulation | pUbi:: OsMYB103L (OE) | Increased secondary cell wall | [58] | |
pUbi:: OsMYB61; NAC29, 31 (OE) | Increased secondary cell wall | [59] | ||
Lignin synthesis | CRISPR/Cas9 | Altered H and G residues; reduced lignin | [60] | |
Fc1 (T-DNA) | Reduced H and G residues; reduced lignin | [8] | ||
p35S::AtSHN2 (OE) | Reduced lignin | [9] | ||
bc1 (ᵧ-rays) | Reduced lignin | [7] | ||
LAC4/LAC7 (T- DNA) | Reduced lignin; hinderance in deposition of G subunits | [61] | ||
TP60 (RNAi) | Reduced lignin; reduced G and S residues | [62] | ||
pWFOsC4H::Bg4CLi (RNAi) | Reduced lignin; reduced S/G ratio | [63] | ||
Altered lignin subunit composition | [64, 65, 66] | |||
Hemicellulose synthesis | axa1 (T-DNA) | Reduced xylose, ferulic acid, coumaric acid | [67] | |
pUbi: OsAt10 | Reduction in matrix bound ferulic acid | [68] | ||
Reduced X/A; affect growth | [69] |
Candidate genes for preferable altering the cell wall polymers (cellulose, hemicellulose and lignin) in plant system.
Alternatively, there is another way of altering the plant cell wall architecture, by curbing the expression of essential genes involved in lignin monomers synthesis (Figure 3). In rice, flexible culm (
A general trade-off has been discovered between saccharification efficiency and ferulic acid [75, 76]. Bartley and co-workers, [68] reported the possible role of OsAt10, a BAHD acetyltransferase gene in achieving higher sugar release by favourably modifying glucuronoarabinoxylan (GAX) in rice. Young leaf tissues of the genetically engineered plants were found to be deficient in ferulic acid (FA). The possible role of other genes such as OsXAX1 and OsIRX10 were known to reciprocate similar results in rice [67, 68].
Cellulose synthase enzymes are pivotal for cellulose synthesis. These proteins organise to form a hexameric ‘rosette’ structure approx. 25–30 nm diameter [77]. The plant cellulose synthase (
Tanaka and co-workers [10] generated four different introgressed lines, showing brittle culm phenotypes by suitably introgressing Tos17, a retroposons in the genetic background of rice wildtype. They identified three cellulose synthase genes namely,
Correlation between biomass traits and grain yield in rice is negative. Breeding varieties for high grain yield usually involves designing the varieties for medium plant height with short erect flag leaves which in turn affect the total biomass yield. This can be addressed to some extent by crossing rice cultivars, showing high polymorphism for grain yield potential as well as biomass traits and identify the candidate genes or QTLs involved. After the successful mapping of genes or, QTLs, the linked markers can be used for marker assisted selection (MAS) as well as can be used to screen the existing wild types or landraces for dual characteristics. As we have discussed earlier, cell wall polymers i.e., cellulose, hemicellulose and lignin composition can be altered for improved saccharification traits, hence, it is essential to search for the genetic link between cell-wall polymer composition and grain yield in order to breed dual purpose rice cultigens [97, 98, 99, 100, 101, 102, 103]. Gui- Fu and co-workers [97] identified few major QTLs associated with three plant traits namely, total biomass yield, straw yield and grain yield by developing suitable doubled haploid population. A QTL co-associated with both cell wall polymer composition and heading date (HD17) has also been identified by crossing parents with considerable polymorphism for the dual characters [102]. Recently, Genome wide association survey (GWAS) involving high throughput molecular markers (SNPs) were employed to identify the genomic regions exhibiting significant association between markers and phenotypic trait and characterise the candidate genes involved [101]. Dissecting the genomic fragments involving lignin and cellulose biosynthesis is possible now with the application of GWAS technique [100].
Pre- existence of variability is of paramount importance in any crop improvement programme. Selection, being the core stone of plant breeding activities, is employed to harness the existing variability present in various germplasms including wild types and landraces, before creating additional variability by mutation.
A preferred high HI for good yield reduces the vegetative biomass of the rice as a whole including reduction in plant height. There is a trade-off for plant height vs. biomass yield. Hence, the role of long- culm rice cultivars in breeding high energy efficient varieties has been given due consideration [104, 105, 106, 107, 108]. However, an increase in culm length may increase the risk of plant lodging, which is a major factor influencing rice grain yield stability especially in direct-seeded rice. A thick culm with tolerable lignin content in cell wall will decrease the risk of plant lodging. So, there should be a balance between the cell wall constitution and morphological characters. Hence, judicious selection of genotypes for increased plant height with thick culm along with high grain yield can address the negative impact exerted by short culm height on overall biomass production. Few researches have enumerated the importance of selecting certain traits such as stem girth, plant height, leaf, sheath and stem weight for higher biomass yield in rice [40, 108, 109].
Another way for breeding dual purpose cultigens is to incorporate ‘stay green’ traits in cultivated type [110, 111]. Varieties possessing these traits are able to maintain higher photosynthetic activity at post-flowering stage, increasing yield thereof. At the same time, higher decomposability of these traits could serve the dual objectives as discussed above. Hence, there is a possible opportunity to exploit this stay green character in developing dual purpose rice genotypes as it has been exploited in other biofuel/bioenergy crops. Also, this character genetically enhances the photosynthetic efficiency, there may be no need to apply extra N inputs. Nevertheless, more research is required in this aspect. As of till date there are no reports of this strategy being exploited in breeding rice varieties for dual purpose.
Next it is important to identify the genetic loci (QTL) associated with these stay green trait and the markers flanking those regions [112, 113, 114, 115]. Various biotechnological tools can then be employed for their successful integration into the plant genome or alternatively, marker aided selection (MAS) can be employed for varietal improvement. Also, heterosis breeding can be used to exploit the possible heterotic gene combinations in remodelling the plant architecture for higher biomass yield in rice, as it has been done in sorghum which possesses similar architectural traits [116, 117, 118, 119].
There is an urgent need to address greenhouse gas emissions (GHGs) and climate changes occurring due to rampant use of fossil fuels. Rice straw, being an abundant source of lignocellulosic feedstock, has the potential to produce green energy to address the above said global concerns. Lignin and hemicellulose complexes act as hinderance to produce energy efficient cultigens and hence, various studies are being made to down regulate the gene involved in their biosynthesis without affecting the plant system and cellulose concentration. Directly engineering cellulose synthase genes also provides an alternative opportunity in designing plant cell wall architecture. Stay green traits and heterosis breeding enhance the opportunity of developing energy efficient varieties to a greater extent. Thus, the role of plant breeding can never be bypassed as careful selection of individuals for dual traits will be highly rewarding in achieving the goal of growing dual-purpose rice varieties.
The authors thank Professor, Biofuel Chair, BPCL-OUAT project, Odisha, India for his guidance and encouragement to write this chapter. The authors also acknowledge the funding provided by the BPCL-OUAT Biofuel project implemented in OUAT, Bhubaneswar, India for the research work.
The authors declare no conflict of interest.
A Wireless Power Transfer (WPT) is one of the promising technologies used to transfer electric energy from a transmitter to a receiver wirelessly. WPT is an attractive solution for many industrial applications due to its enormous benefits over wired connections. The advantages include the no hassle of carrying wires, easy charging, and smoot of power transmission even in unfavorable environmental circumstances.
The idea of wireless power transfer (WPT) was first introduced at the end of the 19th century by Nicola Tesla. He manufactured a wireless lighting bulb that was used to receive electrical charge wireless [1]. Tesla used two metal plates that were closely placed to each other. A high-frequency Alternative Current (AC) potentials were passed between these two plates, and the bulb powered ON. However, some of the issues appeared while using WPT technology. One of the main issues is that the minimum power density and low transfer efficiencies affect when the distances increase. As a result, the performance of WPT technology becomes very slow. Therefore, the WPT technology is improved and used “strong coupled” coils when the distance increases more than 2 m while charging wirelessly [2]. The two important WPT technologies are Inductive Power Transfer (IPT) and Capacitive Power Transfer (CPT). CPT is only applicable to low power applications with very short air gaps between 10–4 and 10–3 m, whereas IPT can be used for large air gaps around several meters, and its output power is much higher than CPT.
Figure 1 Compares between CPT and IPT, Figure 1a shows the power transfer capability versus gap distance with efficiency values. Furthermore the figure indicates both IPT and CPT can achieve ≥90% efficiency at kilowatt power levels in their respective gap ranges. Figure 1b plots the transmitter/receiver area versus throughput power with efficiency. The coupler area is the cross-sectional area through which magnetic or electric fields transfer energy. Figure 1c plots the output power density (output power divided by the gap volume) versus frequency [3]. WPT technologies can be applied in television, phone chargers, and induction heating, medical devices, pacemakers, radiofrequency identification, sensors, robotics, and deeply used in wireless charging for EV [4, 5, 6, 7, 8, 9, 10, 11].
Comparison between CPT and IPT technologies [
In CPT and IPT power transfers, the respective energy stored in a unitary volume of space is
where
Health and safety, and economic impact are the critical points that should be considered in any technology of WPT for charging EVs or in any other applications. WPT technology for charge replacement, EVs can become gorgeous option. WPT charging has the advantage that it can make the charging process automated, suitable and safe for users and large scale introduction of WPT charging infrastructure can help reduce the battery pack size and in turn make the EVs more proficient. However, all this cannot be knowledgeable by using traditional inductive chargers and WPT charging through large air gaps and least possible human interaction are required [12].
WPT systems are primarily classified as microwave, evanescent wave, magnetic resonance, electrical resonance, or electromagnetic induction methods. Scientists have newly proposed an electromagnetic induction method that is not premised on transformer coupling. It is revealed that the electric power transmission over a range including a magnetic field resonance method is enabled by adopting this method [13].
Ampere’s law, Faraday’s law, Maxwell’s equations, the inductive-coupling WPT, the resonance-coupling WPT, and WPT via radio waves are the major theory that can describe the functionality of WPT technologies. Figure 2 shows this relationship between these theories.
Relationship between Ampere’s law, Faraday’s law, Maxwell’s equations, inductive-coupling WPT, resonance-coupling WPT, and WPT via radio waves [
When AC or DC electrical energy is transformed to high-frequency electrical energy by using a high-frequency inverter, the wireless feeding device (Tx.) releases electrical energy through a transmission device into space. Then, the receiving system (Rx.) converts the electrical power into DC in the recipient electrical apparatus. In addition, the efficiency of the electrical power transmission, medical and environmental influence of electromagnetic waves, and improvement the facile high speed charging, safe security, and energy storage density are essential limits should be considered when WPT is designed for EVs.
WPT systems are classified as microwave, evanescent wave, magnetic resonance, electrical resonance, or electromagnetic induction methods. Figure 3 shows the relation between transmitted power and transmitted length of these methods for WPT systems. Additionally, WPT can be classified to the kind of Type 1,Type 2,Type 3 and Type 4 as shown in Figure 4. Table 1 shows the relationship of Types 1–4 from the viewpoint of coupling mechanism, resonant mechanism, and feeding mechanism. Figure 5 shows the general Block diagram of wireless power transfer system [13].
Transmitted power and transmitted length of noncontact WPT methods [
Relationship of different kinds of WPT scheme.
Coupling mechanism, resonant mechanism, and impedance matching mechanism for various kinds of WPT.
Block diagram of WPT system.
Power flow in WPT system.
Figure 7 depicts the base components of a WPT system for EV charging. It consists of two prime sub-systems, one of which is existing underneath the road surface and the second is found into the vehicle underbody [14]. The first subsystem includes the source of energy, rectifier and high frequency inverter, primary compensation network and the primary/transmitter coil (Tx). The built subsystem in EVs, has the secondary/receiving coil (Rx) and secondary compensation network composes a resonance circuit that supplies into a high frequency rectifier, filter and the battery. The sub-systems are separated by an air gap. The distance between the two systems depends on the type of vehicle, ground clearance and road conditions such as pavement thickness. Usually the air gap is smaller than 0.4 m. Additionally, both sub-systems share information via a communication link.
(
The system given in Figure 7 includes:
Distribution network in the road has low-frequency AC power for various loads [15, 16].
Rectifier and power factor correction (PFC).
High-frequency inverter converts the DC power to high frequency AC in the primary side. On the secondary side, the high-frequency AC energy is rectified to DC power and filtered to create a ripple free current that can charge the battery of EVs. The resonant frequency of the compensation topologies and coils determine the required switching frequency of the inverters. Usually used resonance frequencies for WPT EV-chargers are within a range of 20–100 kHz [17].
Compensation networks are located between the high-frequency inverter and the primary coil in the ground assembly (GA), while between the secondary coil and the rectifier in the vehicle assembly (VA). Table 2 summaries these networks and their efficiency. Power transfer efficiency with mutual inductance relationships for the basic compensation topologies SS, SP, PS, and PP are given in Figure 8. An optimal selection operation of the compensation topology based on the economics of the system is proposed in [18]. It concludes that SS and SP-compensation networks are the most appropriate topologies for high-power WPT systems. In addition, SS compensation needs less copper than the other compensation networks.
Communication links. Evenly important to the power transfer system is the communication link between GA and VA. This also contains the communication to the GA grid connection to manage demand upon grid status.
The core components of the WPT system are two coupled coils that allow power transfer via magnetic field [19]. Electric current flows through the primary coil and produces a time-varying magnetic field around it. In the nearness of the primary coil, the secondary coil intercepts the magnetic field, which induces a voltage. The value of induced voltage depends on the air gap length between these coils, the number of turns and the value of dφ/dt; φ is the magnetic flux.
Moreover, different types of coil design are used in WPT, such that Circular, Flux pipe/flat solenoid, Bipolar, Tripolar, Zigzag, DD and DDQ [20, 21, 22, 23, 24, 25, 26].
SS, SP, PS, PP compensation topologies.
Power transfer efficiency characteristics under varying mutual inductance [
Efficiency of resonant WPT with SS and SP topology, and of an inductive WPT vs. QR for different values of QT is reported in Figure 9a, while the efficiency of resonant WPTS with PS and PP topology is given in Figure 9b.
Efficiency of resonant WPTSs with SS, SP, PS and PP topology [
To charge or transfer energy into the vehicle electric storage device, many electrical charging methods are established and standardized. This methods are given if Figure 10.
Classification of charging method for EVs.
Furthermore, there are many other many electrical charging methods uses different converters among different renewable sources [27, 28].
In this chapter, several WPT technologies are presented and explained the importance of WPT. In recent years, WPT technology gains enormous attention due to its advantages. WPT systems are classified as microwave, evanescent wave, magnetic resonance, electrical resonance, or electromagnetic induction methods. Moreover, the prospective EV wireless charging applications are also highlighted, and different coupling techniques are discussed in this chapter. Inductive coupling, magnetic resonance coupling, and microwave are the main EV wireless charging techniques. The chapter also provided detailed information on the manufacturing and configuring the magnetic resonance coupling based wireless charging system. This chapter deals with the basic overview of the present and future scenarios of EVs. After discussing the scenarios, various concerns regarding battery types and charging methodologies are discussed as well.
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
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\\n\\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
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\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
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\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\nDigital Archiving Policy
\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. 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