Point-of-care devices technology are a promising way towards the recognition of pathogens in early-stage diagnosis, which is critical for the success of inexpensive treatments as opposed to the high costs of managing the disease. The integration of immunoassays with read out circuitry allows the implementation of diagnostic devices for their use by untrained personnel, without compromising reliability. In the following chapter, three different biosensors based on lab-on-a-chip (LoC) and microfluidic technologies were designed, assembled and tested for pathogen diagnosis. The devices allowed the effective detection of the human papilloma virus, Mycobacterium tuberculosis and Chagas parasite in shorter times and with smaller sample volumes than those required by current clinical diagnosis techniques. All devices were benchmarked against commercial techniques in terms of cost and time requirement per test.
Part of the book: Biosensing Technologies for the Detection of Pathogens
The use of micromixers and catalytically active nanocomposites can be an attractive alternative for the treatment of wastewaters from the textile industry, due to their high activity, low consumption of such nanocomposites, short reaction times and the possibility to work under continuous operation. In this study, 6 different designs of micromixers were modeled and evaluated for the treatment of wastewaters. Velocity profiles, pressure drops, and flows were analyzed and compared for the different devices under the same mixing conditions. In addition, Life cycle assessment (LCA) methodology was applied to determine their performance in terms of environmental impact. Considering the high environmental impact of water sources contaminated by dyes from the textile industry, it becomes critically important to determine when the proposed micromixers are a suitable alternative for their remediation. The LCA and operational efficiency studies results shown here provide a route for the design of novel wastewater treatment systems by coupling low-cost and high-performance micromixers.
Part of the book: Advances in Microfluidics and Nanofluids