Application of nanocarbon based materials in energy and environmental field.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10",leadTitle:null,fullTitle:"Coherence and Ultrashort Pulse Laser Emission",title:"Coherence and Ultrashort Pulse Laser Emission",subtitle:null,reviewType:"peer-reviewed",abstract:"In this volume, recent contributions on coherence provide a useful perspective on the diversity of various coherent sources of emission and coherent related phenomena of current interest. These papers provide a preamble for a larger collection of contributions on ultrashort pulse laser generation and ultrashort pulse laser phenomena. Papers on ultrashort pulse phenomena include works on few cycle pulses, high-power generation, propagation in various media, to various applications of current interest. Undoubtedly, Coherence and Ultrashort Pulse Emission offers a rich and practical perspective on this rapidly evolving field.",isbn:null,printIsbn:"978-953-307-242-5",pdfIsbn:"978-953-51-4538-7",doi:"10.5772/543",price:159,priceEur:175,priceUsd:205,slug:"coherence-and-ultrashort-pulse-laser-emission",numberOfPages:700,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"e1bd25a76712d1cb8792820acf2ff001",bookSignature:"F. J. 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He is the author and editor of several well-known books on tunable lasers including Dye Laser Principles (Academic, New York, 1990) and Tunable Laser Optics (Elsevier Academic, New York, 2003). His most recent edited work is Tunable Laser Applications, 2nd Edition (CRC, New York, 2009).\r\nDr. Duarte has made key experimental and theoretical contributions to the field of narrow-linewidth tunable laser oscillators. These include original oscillator architectures and the generalized multiple-prism grating dispersion theory. He has also pioneered the use of Dirac’s quantum notation in the description of generalized N-slit interference and classical optics phenomena. Currently, his research focuses on further developments of dispersive narrow-linewidth laser oscillators and very large N-slit laser interferometers.\r\nDr. Duarte’s contributions are cited in some 130 laser and optics books including several classics. 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His research focuses on industrial electronic automation, predictive maintenance, and artificial intelligence methodologies.",institutionString:"PS Solutions",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorFour:null,coeditorFive:null,topics:[{id:"439",title:"Operation Management",slug:"business-management-and-economics-business-administration-operation-management"}],chapters:[{id:"73490",title:"The Analytic Functional Resonance Analysis to Improve Safety Management",slug:"the-analytic-functional-resonance-analysis-to-improve-safety-management",totalDownloads:431,totalCrossrefCites:0,authors:[{id:"181603",title:"Dr.",name:"Antonella",surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo"},{id:"324352",title:"Dr.",name:"Fabio",surname:"De Felice",slug:"fabio-de-felice",fullName:"Fabio De Felice"},{id:"335115",title:"Dr.",name:"Laura",surname:"Petrillo",slug:"laura-petrillo",fullName:"Laura Petrillo"}]},{id:"73483",title:"The Modulus of Resilience for Critical Subsystems",slug:"the-modulus-of-resilience-for-critical-subsystems",totalDownloads:316,totalCrossrefCites:0,authors:[{id:"163601",title:"Dr.",name:"Mario",surname:"Beruvides",slug:"mario-beruvides",fullName:"Mario Beruvides"},{id:"163605",title:"Dr.",name:"Andrea",surname:"Jackman",slug:"andrea-jackman",fullName:"Andrea Jackman"},{id:"324846",title:"Ph.D.",name:"Eric",surname:"Easton",slug:"eric-easton",fullName:"Eric Easton"}]},{id:"73642",title:"Condition-Based Maintenance for Data Center Operations Management",slug:"condition-based-maintenance-for-data-center-operations-management",totalDownloads:811,totalCrossrefCites:0,authors:[{id:"322546",title:"Associate Prof.",name:"Montri",surname:"Wiboonrat",slug:"montri-wiboonrat",fullName:"Montri Wiboonrat"}]},{id:"73410",title:"Harnessing the Multiple Benefits of a Computerised Maintenance Management System",slug:"harnessing-the-multiple-benefits-of-a-computerised-maintenance-management-system",totalDownloads:306,totalCrossrefCites:0,authors:[{id:"324993",title:"Dr.",name:"Edoghogho",surname:"Ogbeifun",slug:"edoghogho-ogbeifun",fullName:"Edoghogho Ogbeifun"},{id:"324994",title:"MSc.",name:"Patrick",surname:"Pasipatorwa",slug:"patrick-pasipatorwa",fullName:"Patrick Pasipatorwa"},{id:"324995",title:"Prof.",name:"J. 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The society is consuming such products at an exponential rate and thereby generating pollutant in terms of fuel combustion, waste generation in the process operation and waste disposal [1]. Till date, due to their maximum operational, and consumption of the conventional energy reserves including, fossil fuel, and coal are the prime factors of increasing the pollutions to the biosphere at such alarming rate. Moreover, their residue generates unwanted carbon like carbon soot interact ecosystem imparts their toxic nature and affects the ecology [2–4].
\nDevelopments of the green environmentally benign materials and its competent with technology advancement are very necessary and now have become a challenging task for the developing eco-friendly society in the biosphere. The concept of zero-waste production, waste prevention, and with use of efficient materials is the prime concerned for the industries, Therefore, for a healthy society, the role of green chemistry is significant, achieving these targets [5]. As it is a well-known mechanism that green chemistry offers a relatively lesser toxic synthesis approach, by reducing the harmful chemical substances in the designing the useful chemical products [6]. Nowadays, due to the unique properties of carbon-based nanomaterials like good electrical conductivity, ease in surface functionalization, high mechanical strength and good thermal stability of carbon-based fullerenes carbon nanotubes (CNTs), carbon quantum dots and graphene, attracted high interest toward research and used widely in many application purposes. Therefore, in the reported literatures, as wonder materials, carbon-nanomaterials have been used directly or modified for aforesaid applications [7]. Although, following complex techniques and expensive hydrocarbons or other specific hazardous source like laser are not easy to handle in different synthesis routes like chemical vapor deposition (CVD), plasma CVD, laser ablation used for the synthesizing the different carbon-based nanomaterials. There are some reported literatures in which an inexpensive and environmentally friendly approach is exploited for recovering the carbon based nanomaterials and experimentally particularly shown their applicability in remediation and sensing applications [8–14]. The synthesis of nanocomposites plays leading role in the current advanced applications purposes such as, energy storage, electronics parts, environmental remediation, biomedicine, etc. [15].
\nPresent book chapter deals with production and potential applications of nanocarbon and nanocarbon-polymer composite materials, with special attention on the energy and environmental related sector and their significant role in enhancing the efficacy for the previously mentioned applications.
\nCarbon have tendency to polymerize into the large molecular weight compounds with long chains due to its unique electronic construction and the smaller size in comparison of group IV that makes it capable of linking with other elements. As it contains four electrons in the valence layers, carbon can easily form covalent bonds with both metals and non-metals. Due to this property, carbon-based compounds can exist in diverse molecular forms, and same type of atoms can be arranged in the different shapes, with different properties known as allotropes. Graphite and diamond are two known natural occurring allotropes of carbon found in the ecology and formed other multiple allotropes of carbon from natural carbon sources for the different purposes. Furthermore, with the knowledge of top down and bottom up approaches of nanotechnology, a new family of carbon nanomaterials as wonder materials is introduced. In recent past years, the different types of carbon nanomaterials have been experimentally tested and successfully developed as advance materials in many engineering applications. In general, carbon nanomaterials exist in between 1 and 100 nm size range; therefore, the unique properties of carbon nanomaterials like good electrical, ionic conductivity, high mechanical and thermal stability at the nanoscale compared with other materials are exceptional and competent for many engineering applications [16]. Carbon nanomaterials are classified further based on their shape and geometrical structures, till dates different forms of carbon nanomaterials that are existing; horn-shaped as nanohorns, tube-shaped as carbon nanotube (CNT), ellipsoidal spherical shape carbon nanospheres (fullerenes), and zero-dimension dots exhibited quantum character as carbon quantum dots (CQDs). Because of excellent properties, carbon nanomaterials have now been extensively used synthesizing the nanocomposite materials that and used in many applications including microchannels, micro/nanoelectronics, textiles, paints, gas storage, composites, conductive plastics, displays, antifouling batteries with excellent durability during cycling-charge. The carbon quantum dots, as a newly emerging biocompatible material, have exhibited fluorescence properties and possess many other valuable excellent properties, such as high aqueous solubility, low cost, low toxicity, abundant surface functional groups and large active surface area for functionalization. Although, besides being used as bio compatible materials, such new class of (carbon quantum dots) nanomaterial are also applied as gas biosensors and heavy metal sensing applications [7, 17, 18]. In particular, the unique features of CQDs as up-converted photoluminescence (PL) behavior and photo-induced electron transferability of CQDs have proposed a new route for harvesting the sunlight from nonconventional reserve, to achieve efficient metal-free photocatalysts [19–21].
\nFullerene as a new class of carbon family had introduced by Kroto, Curl and Smalley [22] in 1985 and denoted as buckminsterfullerene (C60). It is an intermediate allotrope of carbon between graphite and diamond as it constitutes from the bunch of atomic C
CNTs are one of the types of allotrope among carbon-based nanomaterials that have excellent mechanical and electrical properties. CNT are light-weighted, high strength material as compared to steel at nondimensional scale and discovered first by a Japanese scientist S. Ijimain 1991. Nowadays, due to its extraordinary graphic nature and high specific surface area have attracted attention and applied as a pillar material in many engineering applications like battery, electrochemical, pollutant remediation, and used as fillers for nanocarbon-polymer composites [28–30]. CNT exist broadly in two different shapes; cylindrical shaped is formed by rolling of the graphene sheets; and possessed cap fullerene structure appeared in half shape. Based on their geometrical configuration as proficiently qualified is experienced by high voltage electron microscopy techniques. CNT are further classified into two types (i) single-walled carbon nanotube (SWCNT), and (ii) multiwalled nanotube (MWCNT), Carbon nanotubes are prepared in rolled sheets of very few single layer carbon atoms (graphene) form cylindrical molecules. CNT with diameter 1–3 nm and length of few micrometers while for MWCNT, graphene sheets having 0.34 nm of inter-space distance, are stacked like concentric layers in cylindrical form of diameter 5–40 nm. Zhang et al. has been described in a reported literature, which is approximately 550 mm in length [31]. The properties of CNT are basically dependent upon the diameter, size and morphology. There are several methods are reported for CNT preparation like arc discharge, laser ablation, chemical CVD, and plasma CVD. Among the listed methods, arc discharge was the first technique used for the preparation of CNT while laser-ablation method was used to prepare the SWCNT. In the chemical CVD method, small amount of metallic catalysts (Ni and Co) are used to catalyze the hydro-carbon as source at relatively lower temperature for the growth of graphitic surface. The high enhanced electrical property of SWCNTs is due to the presence of the chirality or hexagon orientation with respect to the tube axis, however on bulk scale its synthesis process is very complex and not easy to control the layers. In contrast to the SWCNT, due to the presence of multiple layers, MWCNT possess high mechanical and thermal satiability. Further, based on SWCNTs morphology, it is classified into three subgroups: (i) armchair morphology exhibiting high electrical conductivity than the copper, (ii) zigzag morphology has good semiconductor property and (iii) chiral morphology has semi-conductive property.
\nGraphene is two dimensional, single-atom layer of carbon atoms which are sp2 hybridized and fixed in a rigid hexagonal lattice like a flat plane. Graphene is also a primitive building element of graphite, fullerene and CNT, Graphene was discovered in 2004 by Canadian physicist Wallace. It is an allotropic form of carbon with bond length of 0.142 nm between neighboring atoms of carbon and layer by layer of graphene is stacked with an interplanar spacing of 0.335 nm. The layers of graphene in graphite are bounded by Van der Waal forces [32, 33]. The unique physical properties of graphene, such as, thermal stability, mechanical rigidity and electrical conductivity are higher for few layers of graphene than of their three-dimensional materials. Also, graphene conducts high heat because of high thermal conductivity of graphene in comparison with available excellent heat conductors such as, silver and copper, and much better than graphite and diamond [7, 33].
\nA new class of with unique fluorescent property of carbon nanoparticles discovered accidentally Xu et al. in [34] during purification of SWCNTs. Later in 2006, Sun et al. had given a name of such fluorescent materials as carbon quantum dots (CQDs) particle of size found less than 10 nm. Till date, due to its fascinating property (harvesting optical light and imparting multicolor tuned emission) of CQDs offers a surprising potential material in fields of bio-imaging, photo-degradation and catalysis applications [35]. In last decade, various chemical precursors like citric acid, ammonium citrate, ethylene glycol, benzene, phenylenediamine, phytic acid, and thiourea, have been used for synthesizing CQDs. In order to minimize energy consideration, various synthetic methods, including hydrothermal, solvothermal, electrochemical, microwave assisted pyrolysis, ultrasonication, and chemical oxidation, etc., have been tested to produce the fluorescent CQDs. A number of review and research papers have been focused on the synthesis of such CQDs [36–39]. However, to date there has not been a very few reviews which explicitly focused on green synthesis routes is discussed in details for sensing and bio-imaging of applications [40].
\nFigure 1 describes the different types classification of synthesis routes used in developing the different types of nanocarbons.
\nTypes of synthetic routes of different nanocarbons.
Nanocarbons occur naturally, but not available at abundant scale; therefore, this approach is not very conventional to control the number of graphitic layers, therefore their physical and chemical properties of nanocarbon may vary for engineering applications. There are different types of nanocarbon available from natural synthesis are reported in literature [41]. Velasco-Santos et al. described the existence of carbon nanotubes in the coal/petroleum mixture [42]. SWCNT can be synthesized by CVD, Su and Chen, 2007 and Mracek et al. 2011used metal oxide mixed volcanic lava as a substrate and catalyst [43, 44]. It was noted that process may provide indication for a probable creation of nanomaterials in natural conditions when the temperature rises extremely high, e.g., during volcano eruptions. Like CNT and SWCNT, fullerenes are also found in different ecological materials, for example in the natural mineral shungite from Karelia fullerene is found in low concentrations (2% w/w) [45] and also in meteorite samples of cosmic origin [46]. Chitin is one of the naturally occurring nanomaterials obtained from carbohydrate polymer. Synthesis of chitin nonmaterial considers the following factors such as, thermal dimensional stability, dispersibility, mechanical reinforcements, antibacterial activity etc. depending on the specific goals [47]. Natural nanomaterials can be obtained from polymer waste and its feasibility depends upon processing, recycling, transportation cost, etc. [48].
\nChemical functionalization process formed a huge distinct variety of carbon-based nanomaterials having different functionality, which are applied successfully in different sectors. As the surface functionalization means, carbon-based nanomaterials are added with other groups that ultimately changed its chemical and physical properties [49, 50]. There are many methods of functionalization available for carbon based nanomaterial, such as oxidation, ionic/non-ionic aliphatic aqueous (Hydrophobic), Ionic/Non-ionic aromatic (π-π stacking), Van der Waals’ force (Attraction), Wrapping, doping, and direct deposition. The modification of surfaces is depending on the feasibility and degree of functionalization for the specific application. Therefore, in light of specific application, materials have been synthesized by following different mechanisms like non-covalent bonds, covalent bonds, electrostatic force, hydrogen bonds, Van-der Waals force etc. [51]. Some example of surface modification are as follows; Jiang et al. covered the CNT surface with active sulfate groups by using sodium dodecyl sulfate (NaC12H25SO4) a common surfactant (anionic) for dispersing the sulfate groups [52]. In oxidation process CNT are exposed to mixture of acids via ultrasonic treatment method, during this process, carboxylic groups (–COOH) is attached with CNT surfaces. Oxidation of CNT is very important and creates oxygen carrying groups (–COOH and –OH), which makes CNT feasible for further functionalization without affecting their electrical and mechanical properties [7].
\nThe outstanding physiochemical properties of nanocarbons have triggered interest, toward the applicability of nanocarbons, in multiple area including adsorption, photocatalyst, fertilizer, nanobiotechnology products, environmental materials, and renewable energy related application etc. De Volder et al. reported industrial scale production approximately up to several thousand tons of nanocarbon [17]. Properties like, high thermal stability and mechanical strength of nanocarbon make them suitable alternatively as fillers provides high aspect ratio for nanocomposites materials. Therefore, the prepared nanocomposites materials exhibited enhanced mechanical and other properties as compare to their starting primitive materials [53]. Nasibulin et al. reported the composite material based on cement matrix in which the addition of nanocarbon to original materials exhibited higher strength composite material [54]. Use of low weight, high strength materials in mechanical equipment improves the overall efficiency with low energy consumption. Regarding this use of nanocarbon based materials in energy generating machine such as, turbine as a lightweight and mechanically tough material is desirable [55, 56], and non-corrosive nature and insoluble nature of sp2 hybridized nanocarbon as fillers for marine turbines [57], various electronic applications [58], automotive industry [59], aviation [60], sport equipment allow to use strong and light weighted materials, which generates economical energy generation at optimal energy consumption. Fullerenes and composite based materials are frequently used in pharmaceutical industries [61]. Nowadays, graphene and its composite are frequently in high demands in various applications such as, electronics, solar cell, biochemical sensors [62]. Carbon based nanomaterials based composite materials having excellent properties like high tensile strength, flexibility and good electrical conductivity that make them more favorable for electronics applications [63]. Similarly, the graphene-carbon nanotube/polyvinyl alcohol based composite show high rigidity, strength, and ductility in comparison with conventional nanocarbon materials. Although there is a dramatically increase in the resistivity witnessed for graphene-carbon nanotube/polyvinyl alcohol-based composite, Therefore, such composite materials can be a suitable as a smart stretchable insulator devices using formed by combining the property of conductive nanocarbon materials with epoxy polymer [64].
\nEcological balance is essential which is majorly affected by different pollutants. Therefore, it is difficult to check ecology balance simultaneously with the rapid growth of industrialization and civilization. In this regard, it is required to increase effectiveness by taking some corrective measures in pre-existing methods of controlling pollutions [65, 66]. In light of nanotechnology knowledge, advanced nanomaterial/composite materials can be developed that significantly enhanced the performance of different pre-existing treatment technologies [55, 57]. For example nanocarbon provide high specific surface area thus, carbon-based nanomaterial/composites provide high specific surface for the adsorption process [29, 30] oxidation process [67, 68], and electrochemical applications [69, 70]. Although, the nanocarbon is one of the most effective adsorbents used in the wastewater treatment because of its high surface area to weight ratio. But, it cannot be applied directly in flow or dynamics conditions [71]. Specific affinity of metal functionalized-nanocarbon based materials as adsorbent exhibited high adsorption capacity specific for different heavy metals (As, Fe, Pb, Cu), vitamin B12, nitrates, phosphates and show superior antibacterial activity than that of primitive activated carbon [72–77]. Moreover, after adsorption operation, specific adsorbate with nanocarbon based adsorbent can be separated by the mechanism of filtration and can be recycled [10]. But, high preparation cost of nanocarbon based materials and uncertainties regarding the leaching potential are the major challenges in the application of nanocarbon based materials. Silver coated carbon-based nanomaterials can be used as an antibacterial material and used in disinfection purposes, antimicrobial activity and preparation of biomedical devices [78]. Carbon nanotubes, activated with alcohol 1-octadecanol can also be used as better adsorbent for the absorption of microwaves because of its antibacterial characteristics. So, it can be used in the water purification technologies [79].
\nMoreover, nanocarbons are not only important in the pollution reduction in different ecological sections, but it has significant importance in the monitoring of pollution stages. Carbon-based nanomaterials and their composites can be used for the development of different and efficient sensors (biochemical) to detect very low concentrations of chemical compounds in different environments. For example, carbon nanotubes loaded with ZnO nanoparticles can be used for congo red dye reduction from aqueous solutions and showing that ZnO/MWCNTs is a promising, environmentally friendly and efficient adsorbent for wastewater treatment [80].
\nEconomy of any country is directly boom if they can produce and store energy particularly from renewable resource. In this viewpoint carbon-based nanomaterials and their composites can play an important role in the area of energy harvesting and energy storage. It is well known most of the nanocarbon composed of sp2 hybridization and possessed excellent properties such as, high pore size distribution, high surface area, with enhanced mechanical properties and improved electrical properties. In recent years, nanocarbon and nanocomposites are widely applied for developing energy storage and energy saving devices/instrument. Photovoltaic cells are commonly known as solar cell used as an alternative device for harvest renewable energy sources. Photovoltaic cells can be classified in two categories such as, thin films and crystalline silicon photovoltaic cells. Earlier, silicon, cadmium, copper-based compounds are used in the semiconductors used [81, 82] applied in energy storage devices. Nowadays thin-film group photovoltaic cells used platinum-based semiconductor for high band width/specific related applications. But, high cost and availability of platinum increases overall cost of an instrument. In this case carbon-based nanomaterials/composites can play an alternative role of platinum-based materials due to its superior properties [83]. Generally, nanomaterials prepared from graphene are used to enhance electron carriage and boost the efficiency of solar energy conversion [84]. Graphene-based materials can also be used in fuel cells and batteries due to its favorable properties.
\nSupercapacitors are used for energy storage devices applied in electric vehicles, hybrid electric vehicles, backup power cells, and portable electronic devices due to its advanced properties such as, high-power density, very short charging time, and high cycling stability. The main mechanism of storage of energy in super capacitors are pseudo capacitance and electrochemical double-layer capacitance. In pseudo capacitor, faradic reactions mechanism is responsible for charge transfer processes. Many metals/oxides/conducting polymers are good examples of the pseudo capacitance process. While, in electrochemical double-layer capacitance processes, charges are accumulated at the interface by the mechanism of adsorption/desorption process of electrolyte ions on a large surface area electrode materials. So, in this regards carbon-based nanomaterials can play an important role in the supercapacitor preparations [85]. Supercapacitors based on nanocarbon have many advantages over conventional (metal-based) supercapacitor, such as, high cycling stability, high power density and low energy density limits for their applications in batteries [86].
\nExcellent mechanical and electrical properties of nan0carbon-based materials (carbon nanotube) offer an exposed surface to functionalize and make them suitable for energy storage. But, it has some disadvantages such as, moderate capacitance due to low density of nanomaterials [87]. The lithium-ion battery is alternative type of energy storing substance, which holds energy as a chemical energy. It has many advantages over capacitors such as, high power density, and less greenhouse gas emissions possibilities [88]. Nanocarbon materials/composites are used in the lithium batteries because structure of the nanocarbon-based material usually express some common factors such as, the amount of lithium that is reversibly incorporated into the carbon lattice, the faradic losses during the first charge–discharge cycle, and the voltage profile during charging and discharging.
\nCarbon based nanomaterials such as, carbon nanotubes, activated carbons, and graphene based nanosheets are suitable for sustainable energy storage devices, because, carbon materials have many favorable properties such as, light weight, low cost, easy processability, adaptable porosity, and simplicity of chemical modification [89]. Generally, higher specific surface area and pore size distribution of nanocarbon structures allow them to increase the performance of electrochemical capacitance in terms of both the power delivery rate and the energy storage capacity. Some nanocarbon based materials used in the environmental and energy application are shown in Table 1.
\n\n | SN | \nNanomaterials | \nMethod | \nMaterials used | \nConditions | \nApplication | \nRef | \n
---|---|---|---|---|---|---|---|
Environmental Application | \n1 | \nMultiwall carbon nanotube | \nOxidation, filtration, drying | \nH2SO4: HNO3 (3:1) | \nSonicated; 3 h; 40°C | \nHeavy metal removal (Cadmium reduction) | \n[67] | \n
2 | \nOxidized multiwall carbon nanotube | \nEDA, N - HATU, filtration, drying | \nNH2 materials | \nSonicated; 4 h; 40°C | \nHeavy metal removals (Cadmium and lead reduction) | \n[68] | \n|
3 | \nMultiwall carbon nanotube | \nOxidation/reduction/pyrolysis | \nEthanol/ferrocene/thiophene | \nAirflow, 400°C, argon flow, 600–900°C | \nciprofloxacin reduction from aqueous solution | \n[90] | \n|
4 | \nGraphitic oxide | \nOxidation, filtered; washed; dispersed | \nNaNO3, H2SO4, KMnO4, H2O2 | \nVigorous agitation 20–66°C, dilution: 98°C, 15 min | \nWastewater treatment | \n[91] | \n|
5 | \nGraphite Oxide | \nOxidation, sonicated; washed; dried | \nNa2S2O3 | \nSonicated; 1 h, disproportionation; 30 min | \nHeavy metal removal (mercury Hg2+ reduction) | \n[92] | \n|
Energy Application | \n6 | \nGraphite powder | \nHeating, drying, filtration, mixing | \nK2S2O8, P2O5, H2SO4, KMnO4, H2O2 | \nHeating: 80°C, ice bath: 20–35°C, mixing: 35°C for 2 h | \nFabricating of various microelectrical devices | \n[93] | \n
7 | \nGraphene oxide, graphene nanoplatelets | \nHeating, drying, filtration, mixing | \nPolyethylene glycol, H3PO4, KMnO4, H2SO4, HCl, H2O2 | \nMixing: 50-0 °C for 12 h, Drying: 50°C, sonicated; 1 h | \nTo prepare higher thermal energy storage material | \n[94] | \n|
8 | \nSingle wall carbon nanotube | \nAbsorption, drying, Nitration | \nHNO3, Ag/AgCl electrode, methylene blue | \nNitration: 10 h, methylene blue doping: 3 h | \nApplication in biofuel. | \n[95] | \n|
9 | \ncarbon nanotubes | \nMelting/heating, sonicated | \ngraphite nanoplatelets, phase change materials | \nHeating: 60°C, ultrasonicated at pulse velocity of 25 m/s for 20 min | \nTo prepare enhanced thermal conductive material | \n[96] | \n|
10 | \nPorous carbon and hydrous RuO2 | \nOxidation, absorption | \nSulfuric acid | \n\n | Supercapacitor for energy storage | \n[97] | \n
Application of nanocarbon based materials in energy and environmental field.
This book chapter has focused on the application of nanocarbon-based materials/composites in the environmental and energy relevant area. Numerous exceptional properties of nanocarbon based such as, outstanding pore size distribution, large surface area, ease of porous texture modification, mechanical, thermal stability and chemical deformation make them appropriate for the different application. Overall functional group related to nanocarbon attached with specific materials/metals and increases the electrical, thermal and other desirable properties of the composite. Modified nanocarbon-based materials with enhanced electronics properties can be used for the different electronics devices in energy relevant area such as energy storage, conduction, radiation, etc., and environment relevant area such as, pollution parameter detecting devices. Higher surface area of nanocarbon based materials in comparison with conventional materials can be used in the pollution remediation application. Antibacterial nature of nanocarbon based materials can also be used in wastewater treatment for disinfection process and it can be used in preparation of biomedical relevant area to minimize bacterial contamination.
\nAcrylamide (ACR), a water-soluble vinyl monomer, is a by-product of foods rich in carbohydrates that are cooked at higher temperatures. It has been shown to evoke genotoxic, carcinogenic, and neurotoxic effects in various kinds of animal species [1]. When exposed to humans through lifestyle, diet, occupation, and various other environmental factors it can cause adverse neurotoxic effects like ataxia, peripheral neuropathy and may result in the pathogenesis of neurodegenerative diseases. ACR could be found as a result of the use of polyacrylamide (PAM) in the environment. It can be seen in ingredients that are eaten by humans daily, including biscuits, breakfast cereals, bread, and crackers [2]. They are also used in cosmetics and toiletries, paper and textile production, production of dyes and organic chemicals, sugar refining, etc. PAM depolymerizes when it is exposed to high temperatures or pH to form ACR causing contamination to the environment [3]. Some other ways of exposure to ACR are through oral, inhalation, and dermal routes. It is formed from the amino acid asparagine during high-temperature cooking like baking and frying. Studies have reported that ACR is obtained from reducing sugars and the amino acid asparagine through the Maillard reaction [2]. Asparagine has been considered to be a major precursor of ACR, and heating foods having high starch content such as potatoes can result in high levels of asparagine eventually resulting in high ACR formation [4]. Rats subjected to specific time and dose-dependent measures of ACR have shown decreased norepinephrine levels and density of noradrenergic axons in different parts of the brain showing morphological evidence. According to the US FDA, a survey of 2015 on ACR values in individual food product samples, 70 ppb of ACR level was found for bread and bakery products, 500 ppb for Nuts and Fruits, and 1030 ppb for French Fries and Other Potato Foods. The no-observed-adverse-effect limit (NOAEL) and lowest observed adverse effect level (LOAEL) for laboratory animals is 0.2–0.5 μg/kg/day and 2 μg/kg/day respectively whereas the mean dietary exposure estimated by the World Health Organisation (WHO) is 0.001 cmg/kg/day [5]. It is, therefore, crucial to identify the cause of and exposure to ACR, its ways of reduction, and the health risks that are involved to establish a safer environment. The European Food Safety Authority (EFSA) has estimated the Benchmark Dose Lower Confidence Limit (BMDL) for ACR. For tumours, experts chose a BMDL10 of 0.17 mg/kg bw/day and for other effects, neurological alterations were seen to be closely related with a BMDL10 of 0.43 mg/kg bw/day [6]. Currently, many mitigation strategies are being investigated for their therapeutic effects against ACR present in the environment. Due to the harmful effects of ACR, research focuses on human health risks, dietary exposure to ACR, and its limit in foods by modulating processing ACR [3, 4].
Although the exact mechanism of ACR toxicity is still under investigation, many studies have shown that an imbalance in the antioxidant system can be one of the major reasons [7]. However, the US FDA [8] suggests that the level of ACR used in laboratory studies is higher than what humans are exposed through food. Also, the study by [9] states that more investigation is required to establish occupational exposure levels of ACR.
This review chapter aims to throw light on ACR as a neurotoxin and hazardous waste by discussing various aspects like the occurrence of ACR as a hazardous waste, effects of ACR and its by-products, ACR induced neurotoxicity leading to neurodegenerative changes and the potential of different therapeutic strategies to mitigate the toxicity.
ACR is a monomer and may be found in the environment because of the use of PAM polymers. ACR and its derivatives are used as sewage-flocculating agents and mainly occur in mineral extraction and chemical and food processing industries [10]. PAMs are agents also used in soil conditioning and strengthening in paper manufacturing [11]. ACR contaminates water through the use of PAM polymers in a range of industries such as agricultural, oil drilling, cement, herbicide, paper production, cosmetics, soap, chalk, adhesives, dyes, explosives, printing inks, and latex. All of these PAM applications, particularly flocculants and soil stabilisers, are potential sources of PAM contamination in drinking water supplies. Toxicity testing with some PAM-sensitive aquatic organisms revealed that oil-based PAM was harmful, whereas water-based PAM products were not. The cationic PAM has a lethal concentration (LC50a) of 0.3–10 mg/L, and it adheres to fish gills, obstructing the osmoregulation system. Several studies have found that anionic PAM products are safer to use in environmental water than cationic and neutral PAM products. Rainbow trout, especially larger fish rather than fingerlings, have seen acute alterations in their gills at LC as a result of cationic PAM poisoning. Due to ACR exposure, goldfish developed acute tissue lesions in the pancreas and genotoxic damages in their erythrocytes, disrupting homeostasis and eventually having a carcinogenic effect. It is also noted that ACR is not accumulated in sludges produced by PAM flocculants [10]. At room temperature, ACR is a solid, however it is extremely soluble (2155 g L1 of water) and mobile in water [12]. The major source of ACR in drinking water is the residual monomer of PAM, which is released throughout the treatment process. PAMs can be a source of release to drinking water sources when used as a chemical grouting agent and soil stabiliser in the building of tunnels, sewers, wells, reservoirs, and dams. ACR is also released into water by plastic and dye industries. Because ACR does not participate in soil binding but is extremely soluble and mobile in water, it will travel quickly with seepage, increasing the risk of pollution of surface or groundwater [13]. The concentration of ACR in aquatic and terrestrial ecosystems around ACR or PAM using—industries was found to be 0.3 ppb to 5 ppm [14].
Individuals inhale ACR mostly through smoking [15]. The amount of haemoglobin adduct identified was precisely related to the amount of ACR inhaled from three cigarettes each day [16]. Continuous ACR exposure, particularly by blue-collar workers, has been linked to headaches, muscle weakness, increased sensitivity in their extremities, dyspnea, and in certain cases, balance impairment, paresthesia, discomfort, and truncal ataxia [13]. The average ACR level per cigarette is 679.3 ng, with a range of 455.0–822.5 ng per cigarette. Adult smokers in Poland are predicted to be exposed to 0.17 g/kg b.w. of ACR per day via tobacco smoke [17]. It has been stated that each cigarette contains an average of 1.2 μg of ACR. According to the study, smoking 20 cigarettes per day exposes the body to 0.5 μg/kg b.w. per day [18]. ACR poisoning causes rashes, peeling of the skin and hands, cramping, and sweating, among other symptoms. It’s also a skin irritant that causes peeling contact dermatitis on the palms, which can lead to neurologic conditions. In humans, dermal exposure can cause an exfoliative reddish rash [13, 19, 20]. In a study including two grouting workers, it was observed that one has experienced skin peeling after 2 weeks of exposure to high concentration of ACR and systemic neuropathy in the next 6 months whereas the other worker showed cerebellar dysfunctions, including gait ataxia and slurred speech after 1-month exposure [19]. The use of ACR in cosmetics is a risk to the population. Due to ACR toxicity, the initial approved dose of 100 mg.kg−1 cosmetic product was reduced to 0.5 mg.kg−1 therefore the daily exposure due to cosmetics has lowered to 0.7 g.kg−1 b.w. per day.
ACR can play a direct role in the toxicological effects of sperm morphology, motility, and production, as well as being an indirect cause of reproductive issues as shown by various studies done on ACR exposed male mice [16, 19]. Repeated injections of ACR (20 mg/kg) into male rats for 20 days resulted in dose-dependent reductions in testosterone and prolactin levels [21]. In another study it was observed, after a one-month experiment, ACR exposure at levels of 1.25–24 mg/kg/day in their drinking water lowered fertility rates and litter sizes in mice, while increasing morphological anomalies of sperm and embryo resorption rates. In animal toxicity experiments using ACR, decreased reproductive behaviour, testicular atrophy, aberrant spermatogenesis, and poor sperm quality are some of the symptoms [13]. Peripheral neuropathies caused by ACR, such as decreased hind-limb function, may impede copulatory behaviour, mounting responses, and intromission, eventually impact the sperm deposition in the vagina and uterus, as well as cause hormonal alterations. In terms of hormonal mechanisms of action, ACR decreased serum testosterone and prolactin levels, which could contribute to testicular shrinkage and sperm motility [22].
When the nervous systems of humans and animals are exposed to excessive quantities of ACR, α, β unsaturated carbonyl molecule with strong chemical activity, it can cause cancer and neurotoxicity [23]. ACR and its metabolites have been shown to be both genotoxic and carcinogenic in various studies [24, 25]. When ACR enters the body, it is oxidised and transformed into the genotoxic metabolite glycidamide (GA) [26]. ACR is ingested in the digestive system and transported to the liver at a rate of 4 mol ACR per 1 mol haemoglobin, where it is processed and destroyed by two distinct routes. The carcinogenic action of ACR, which is metabolised to GA in the liver by CYP2E1, has a mutagenic effect in the brain, kidneys, lungs, uterus, and testis in several organisms that includes experimental animals as well [27]. It was discovered that the genotoxic effect on DNA was mostly caused by GA, an ACR metabolite, rather than ACR itself [28]. The conversion of ACR to GA was found to be quite common in rats and mice, and it’s mode of action included it’s interaction with purine bases in the liver, renal, and pulmonary DNAs of rats and mice, causing genotoxic impacts [24, 25]. ACR also induced gene mutations and chromosomal defects in cultured mouse embryonic fibroblast cells, according to in vitro experiments [29, 30].
In this chapter, we have focused on neurotoxic effects caused by ACR in rats. ACR is predominantly known as a neurotoxin in humans. In this chapter, we are discussing ACR induced neurotoxicity in rat models where extensive studies have been done.
Studies have been made to understand the relation between the dose response and effect of ACR in rats. ACR has shown remarkable toxic effects with acute doses from the very beginning [31]. The response has been found to vary with the dose of exposure. The different doses of ACR to which the rat model has been exposed to be discussed to understand the dose-effect of ACR includes 0.5–50 mg/kg [1, 7, 31, 32, 33, 34, 35, 36] (Table 1). In rats, the NOAEL for ACR induced neurotoxicity was 0.5 mg/kg body weight/day and the LOAEL was 2 mg/kg-day in F344 male rats for the most sensitive effect (microscopic nerve alterations).
No. of days of exposure | Dose of exposure (mg/kg) | Effects | References |
---|---|---|---|
24 hours | 0.5, 2.5, 12.5 | No apoptotic neuronal death, decrease in GSH. | [1] |
10 days | 38.27 (1/3rd dose of LD50) | Decreased in GSH, SOD, CAT and AChE activity and increase in LPO. | [36] |
12 days | 40 | Weight loss, gait abnormality, Purkinje cell nuclear condensation, DNA damage in rat cerebellum were observed after the exposure period. | [1] |
21 days (3 weeks) | 25 | A decrease in the haematological parameters, brain NT concentrations, AChE activity, antioxidant biomarkers. Elevation in the levels of oxidative stress biomarkers. Astrocytosis was also observed. | [7] |
28 days (4 weeks) | 5 | Increase in weight but no neurotoxicity observed | [33, 35] |
15, 30 | Uncoordinated motor movement, nervous function defects, increase in the quantity of abnormal neurons distributed in varied layers of the cerebral cortex and wide distribution of astrocytes in the brain was observed. | ||
40 | A significant loss in body weight, continuing deficits in motor function, adverse pathological changes in the cortex and hippocampus of rats. | ||
30 days | 20 | Impairment in motor performance and cognition, a decrease in brain GSH and SOD. | [32] |
Dose and time dependent exposure of acrylamide in rats.
The principle mechanism of ACR neurotoxicity is unknown, but some studies have linked it with the reduction in antioxidative capacity and inflammatory responses [7]. Oxidative stress which occurs due to the imbalance between the production and the removal of reactive oxygen species (ROS), free radicals and antioxidants, is evident in neurological disorders like Alzheimer’s disease (AD), Huntington’s disease (HD) and Parkinson’s disease (PD), ataxia, peripheral neuropathy, amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) [37, 38, 39, 40]. Antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px) neutralise the effects of free radicals but due to the pro-oxidant effect of ACR, the levels of these enzyme are decreased resulting in an imbalance between the production and removal of free radicals by elevating the oxidative stress markers like ROS and thereby inducing lipid peroxidation (LPO) [33, 41, 42, 43] (Figure 1). Like many other xenobiotic compounds, ACR is an electrophile that can interact with nucleophiles containing specific residues [43]. It reacts with molecules that consist of bisulfide (SH), azanide (NH2) or hydroxide (OH). Glutathione (GSH) is a thiol that is well known for its free radical and ROS scavenging property [7, 33, 34]. Previous research has established that rats administered with ACR have a significant decrease of GSH in brain tissue when compared to the control group [33, 34, 44, 45]. The reduction in GSH levels results in an increase in levels of ROS that accumulates and induces oxidative stress. GSH is a nonenzymatic antioxidant that also acts as a coenzyme for the peroxide decomposition enzyme GSH-Px [7]. Studies also suggest that LPO is an effect of low levels of GSH [46, 47, 48]. First-line defence enzymatic antioxidants like SOD, CAT and GSH-Px have reduced in ACR-treated rats [33, 42, 45, 47]. GST is an antioxidant enzyme used to maintain the free radical balance. ACR was shown to enhance GST activity, suggesting an increase in the synthesis of S-conjugates between ACR and GSH [43, 46]. In contrast, a study by [47] reported a decrease in GST activity while measuring ACR-treated rat brains. As a result of the changes in levels and activity of various antioxidant enzymes and molecules, the concentration of total oxidants and antioxidants are increased and decreased respectively [49]. LPO, protein damage and DNA damage are biomarkers for oxidative stress in neurodegenerative diseases [39, 50].
Role of oxidative stress in ACR induced neurotoxicity.
LPO is the degradation of lipids by free radicals and is assessed by measuring the levels of its marker, malondialdehyde (MDA). Thiobarbituric acid reactive substance (TBARS) assay is used to measure MDA, where it reacts with TBA and produces a pink-coloured complex [51]. MDA is formed by the free radicals generated from LPO and causes protein oxidation. Several lines of evidence suggest that exposing rats to ACR have high contents of MDA in the brain when compared to control groups [33, 40, 44, 47].
Protein oxidation is considered as the damage of proteins. To understand the level of extent of this effect, the protein carbonyl content is the marker to understand oxidative damage in rats that have been treated with ACR. The Dinitrophenylhydrazine (DNPH) assay is used to measure the levels of protein-hydrazone to quantify the protein carbonyl content [42].
Since GA binds to the DNA and causes detrimental effects, it is important to understand the genotoxicity of ACR on rats. A commonly used DNA damage marker for oxidative stress is 8-OHdG, which is quantified by ELISA kits [52]. The principle mechanism of ACR-induced neurotoxicity is widely accepted to be apoptosis induced by ACR in rats [33]. ROS induces cell death via apoptotic mechanisms that are either non-physiological or controlled [53]. Telomerase reverse transcriptase (TERT) is an apoptosis-related molecule and is influenced by oxidative stress because of its anti-apoptotic effect. When ACR was administered to rats TERT associated mRNA and protein expression was downregulated in the rat brain [33, 54]. The sensitivity of cells to various apoptotic stimuli is determined by the ratio of anti-apoptotic protein B-cell lymphoma 2 (Bcl2) to pro-cell death proteins such as Bax and Bad, these ratios and the relative density of caspase-3 and caspase-9 is higher in ACR treated rats [37, 41, 55]. Proteins involved in apoptosis signalling pathways and cellular functions are also influenced by the presence of ACR. An appropriate balance must be maintained within the mitogen activated protein kinases (MAPKs) for regulating apoptosis. But, when ACR is induced, due to excessive ROS production a reduction in P-ERK/ERK ratio and elevation in the P-JNK/JNK and P-P38/P38 is observed, this causes mitochondrial dysfunction [1, 41].
The main neurotoxic consequences of ACR are peripheral nervous system (PNS) degradation and degeneration in a brain area related to learning and memory function. Drowsiness, cerebellar ataxia, muscle atrophy, dysarthria, and sensory or motor peripheral polyneuropathy are common clinical symptoms [56, 57]. ACR-induced neurotoxicity is associated with symptoms like ataxia, hindfoot splay, skeletal muscle weakness, and numbness of the hands and feet [1, 58]. ACR-induced neurodegenerative diseases have been shown in various studies to be mediated by axon and medullary sheath destruction in the PNS [59]. Distal axon swelling and degeneration are the key pathological features of ACR exposure [56, 60]. Even though recent research studies report that ACR-induced neurotoxicity and neurodegenerative effects in humans and experimental animals are mediated by nerve terminal and axonal damage, the exact underlying mechanism remains unclear [58].
Recent research has revealed that ACR-induced locomotor abnormalities and neurotoxicity are comparable to the effects seen in PD, as ACR can cause key parkinsonian pathology such as α- synuclein aggregation [61]. The prominent hallmark of PD is the depletion of monoamine neurotransmitters (NTs) known as dopamine (DA) and its associated loss of dopaminergic A9 neurons in the substantia nigra pars compacta and striatum [58, 62, 63]. Motor control, cognitive decline, muscular stiffness, body posture instability, and movement difficulties are symptoms associated with the loss of dopaminergic A9 neurons [62]. DA, a kind of catecholamine, is a NT that governs important functions like cognition, motor control, emotion, and neuroendocrine activity [1, 7, 63]. A massive proportion of DA-carrying nigrostriatal neurons can be found in the striatum, which is the largest integral processing unit present in the basal ganglia [1, 63]. Tyrosine hydroxylase (TH) is a rate-limiting enzyme that is accountable for the synthesis of DA. TH helps to convert tyrosine into 3,4-dihydroxyphenylalanine (DOPA). DOPA is further converted to DA by the action of the enzyme, aromatic amino acid decarboxylase. Cells that are TH-positive are represented as dopaminergic neurons [1, 63, 64]. ACR is most commonly administered to rats either through their oral gavage or through intraperitoneal injection. When ACR is injected in this form, it gets metabolised into GA because of chromosome P450-2E1 present in the liver microsomes. DNA adducts that are formed as a result of the interaction between GA and DNA are responsible for provoking modxicity and carcinogenicity. Since ACR-induced neurotoxicity is strongly associated with the monomer of ACR itself, intracerebroventricular injection aids in transmitting the ACR to the neurons without resulting in the formation of GA. Studies have reported that rats treated with ACR through intracerebroventricular injection have shown a serious decline in the protein expression of TH and the number of TH-positive cells belonging to the striatum [1].
Neuronal apoptosis results in the death of neuronal cells gradually leading to the development of neurodegenerative diseases. Neuronal apoptosis, a definite form of cell death, has a pivotal function in ACR-induced neurotoxicity in rats [65]. Studies have reported that ACR can result in neuronal apoptosis of the striatum. Nissl body is a chromatophilic substance that is very specific and is found in the cytoplasm of neuronal dendrites. Besides protein synthesis, Nissl bodies are crucial for brain functions like memory and learning. Since protein synthesis is essential for proper neuronal function, the presence of the Nissl body is indispensable. Rats treated with ACR reported the presence of pyknotic nuclei and the disappearance of Nissl substance in the striatal neurons. Striatal neurons treated with ACR also appeared swollen with decreased cellular integrity and exhibited an irregular arrangement [60]. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) staining is generally performed to investigate the loss of neurons due to apoptosis. Recent studies have reported that ACR treatment in rats has significantly raised the levels of TUNEL-positive cells in the rat striatum, which suggests that ACR exposure can result in striatal dopaminergic neuronal apoptosis. Hence, these kinds of studies suggest that ACR can also be a significant environmental risk factor for diseases like PD [1].
To be able to mitigate the neurotoxic effects of ACR, therapeutic agents of different types are used at different doses. Phytoconstituents have been widely studied for amelioration of neurotoxicity in rats but there are adequate studies on dietary supplements, drugs and probiotics (Figure 2).
Effects of therapeutic agents on neurotoxicity caused by acrylamide.
Few phytochemicals are thymoquinone, curcumin and quercetin. The anti-apoptotic property of thymoquinone plays a crucial role in attenuating the toxicity induced by ACR in rats by mitigating oxidative stress, reducing Bax/Bcl ratio, maintaining the integrity of the blood brain barrier (BBB), decreasing the level of caspase 3 and 9 and reducing glial fibrillary acidic protein (GFAP) content which indicates astrocyte damage [41, 66]. Curcumin increased the number of TERT positive cells and decreased the number of TUNEL positive cells in the cortex of ACR treated rats. Additionally, curcumin can also cross the BBB and alleviate spatial memory damage induced by ACR [33, 67]. Quercetin enhanced DA and serotonin levels, reduced biomarkers of oxidative stress, restored acetylcholinesterase (AChE) activity in ACR-treated rats. It can move across the BBB and exhibit its therapeutic efficiency [36, 68, 69]. Other compounds like metformin, minocycline and zolpidem also show similar therapeutic effects to dietary supplements when administered to ACR-treated rats [70, 71, 72] (Table 2).
Therapeutic agents | Methods of exposure | Time exposure | Dose | References | |
---|---|---|---|---|---|
ACR (mg/kg) | Agent | ||||
Thymoquinone | Primary treatment with Agent and followed by a concomitant treatment (ACR + AGENT) | 11 days | 50 | 2.5, 5, 10 mg/kg | [41, 66] |
Concomitant (ACR + AGENT) | 11 days | 50 | 2.5, 5, 10 mg/kg | ||
Curcumin | ACR + AGENT | 4 weeks | 40 | 50, 100 mg/kg | [33] |
Concomitant (ACR + AGENT) | 7 weeks | 10 | 90 mg/kg | [67] | |
Quercetin | Agent followed by ACR | 5 days | 50 | 10 mg/kg | [68] |
ACR followed by Agent | 10 days | 38.27 | 5, 10, 20, 40 mg/kg | [36] | |
ACR followed by Agent | 30 days | 20 | 25, 50 mg/kg | [69] | |
Vitamin E | Concomitant (ACR + AGENT) | 20 days | 5 | 100 mg/kg | [49, 73] |
Concomitant (ACR + AGENT) | 28 days | 20 | 50 IU/kg | ||
ACR followed by Agent | 42 days | 20 | 50 IU/kg | ||
Vitamin C | ACR + Agent | 21 days | 10 | 200 mg/kg | [74] |
Vitamin F | ACR followed by agent | 13 days | 38.27 | 5, 10, 20, 40 mg/kg | [75] |
Omega-3 Fish oil | Concomitant (ACR + Agent) | 8 weeks | 45 | 200 mg/kg | [65, 76, 77] |
Agent followed by ACR | 30 days | 30 | 0.5 ml/kg | ||
Melatonin | ACR + Agent | 21 days | 50 | 10 mg/kg | [34, 78, 79] |
Therapeutic agents that attenuate acrylamide neurotoxicity in rats by different methods of exposure at various doses and times.
Vitamins have shown therapeutic effects when administered to ACR-induced rats by ameliorating their toxic effects. Vitamins like vitamin E, vitamin F, vitamin C and vitamin B6 have been studied for their ameliorative property on rats influenced by ACR neurotoxicity [37, 74, 75]. They are widely known for their powerful antioxidative property and are also used as positive control groups while evaluating the potential of other therapeutic agents against ACR toxicity in rats [41, 80]. Vitamin E is phospholipid soluble and a neuroprotective antioxidant. It elevated brain-derived neurotrophic factor levels and lessened oxidative stress through its sweeper effect and removed free radicals in the brain tissue of fetal rats [49]. It also attenuated inflammation, apoptosis and behavioural neurotoxic effects in rats [37, 73]. Linoleic Acid (LA) is an essential omega-6 fatty acid with antioxidative, anti-inflammatory and neuroprotective effects [75]. LA improved ACR oxidative effects by restoring the activities of antioxidant enzymes, reducing the generation of free radicals, preventing LPO and obstructing genotoxic damage by reducing GA. AchE activity was also ameliorated by restoring vacuolization loss by pyramidal cells and Purkinje cells [75]. Vitamin B6 was also able to attenuate the intensity of ACR effects by increasing the availability of energy to the neurons [81]. When administered to pregnant rats vitamin C lessens the effects in white matter volume, the volume of the cerebellar cortex, molecular and granular layer volume and cerebellum damage [74]. Omega-3 fatty acids have also been studied as a therapeutic agent that can attenuate neurotoxicity caused by ACR in rats. Fish oil was able to reduce the neurotoxic effects evoked by ACR in rats. It restored oxidative stress by improving MDA, GSH, LPO, protein carbonyl content, free radicals and antioxidant status [65, 76]. Omega-3 Polyunsaturated fatty acids (PUFAs) regulate neurotransmission by modulating the activity of NTs. They also attenuate apoptosis by increasing anti-apoptotic BCL-2, expressing Hsp27 and inducing oligodendrogenesis [77]. Fish oil mitigates inflammation and astrogliosis by reducing inflammatory cytokines and GFAP positive cells [76]. Melatonin (MT) alleviates DNA damage, levels of MDA, SOD, GSH-Px, GSH and nucleus concentration [34, 78]. It relieved weight loss and gait abnormality. MT shows an increase in the levels of brain NTs and a reduction in AchE activity, serum tumour necrosis factor (TNF)—α and cortical amyloid protein levels [79]. MT treatment restored ACR evoked oxidative stress by down-regulating Nrf2, nuclear factor kappa B (NF-kB) and Kelch-like ECH-associated protein 1 (Keap-1) activity (Table 2) [78].
Probiotics maintain the intestinal barrier by increasing the expression of tight junction proteins, they can even reduce toxic substance absorption in the gut and enhance angiogenic activities in the central nervous system (CNS) [45, 82]. Lactobacillus plantarum (
In many countries, the current standard for ACR concentration in drinking water is 0.25 g/litre. It is advised to maintain the level of ACR monomer at 0.05 percent in PAM used in wastewater treatment. A wide range of microbes can degrade ACR, but there exists a latent period before this occurs. However, in regions with low microbial activity, ACR may remain in the environment for days, weeks or even months. ACR contamination also occurs during sewage treatment. This can be mitigated by chemically decontaminating ACR containing effluents [87]. The limitation set by Food and Drug Administration is of 0.2 percent (2 g/kg) monomer in PAM for use in paper or food or cardboard. In the Federal Republic of Germany, the amount of PAM in packaged foods is regulated to 0.3 percent (3 g/kg) and the amount of residual ACR monomer is limited to 0.2 percent (2 g/kg). Various methods such as addition of divalent cations, replacement of reducing sugars with sucrose or addition of organic acids, addition of calcium salts, using glycine to dilute the asparagine level, reduction in the free asparagine concentration by asparaginase or substitution of ammonium salts with baking powder, are suggested in recent years to mitigate the formation of ACR in heat processed foods [87].
The study by [88] showed a decline in ACR content in baked corn chips and French fries by pre-treating the potato cuts with citric acid solution prior to frying. The citric acid solution was able to lower the pH and leach out the asparagine and reduce sugar from the potato cuts. Aiswarya and Baskar [89] showed that the pre-treatment of potato with asparaginase prior to frying was effective in reducing the ACR content in fried potato chips. The effects of NaCl and citric acid combined with asparaginase was also studied and it was found that the use of NaCl + asparaginase and citric acid + asparaginase was effective in reducing ACR levels. To prevent workers from absorbing more than 0.012 mg/kg body weight per day during their occupational exposure, preventive measures such as enclosing production activities and wearing protective garments should be implemented. In the workroom, the concentration of ACR in the air should not exceed 0.1 mg/m3. To avoid inhaling ACR, ventilated face masks can be worn. It’s likely that the underlying neurological disease and/or the administration of neuroactive treatments modify human sensitivity to ACR, but no particular recommendations could be given until there is evidence [87].
Many studies have identified the potential health risks of ACR and the ambiguity of the mechanisms underlying ACR induced neurotoxicity has gained interest. Current toxicological studies are insufficient to indicate that ACR amounts consumed in the normal diet are likely to result in adverse human health effects. ACR is considered to be a potential health hazard that can impact toxicity to humans. An overview of their occurrence and effects have been comprehended in this review chapter. The importance of oxidative stress, dose and time variations in exposed rat models is being used to comprehend the mechanisms and the neurotoxic effects induced by ACR in rat models. ACR, a toxic neurotoxin is associated with the pathogenesis of various neurodegenerative diseases and their effects on neuronal apoptosis are analysed. Various therapeutic agents against ACR induced neurotoxicity have been analysed to understand their ameliorative effect. This review would give an overall insight on the toxicological effects of acrylamide and provides a comprehensive approach about the recent findings on how to mitigate the formation of acrylamide by using effective therapeutic strategies. More research at the cellular level will aid in the identification of early biomarkers that can be utilised to detect, avoid or mitigate the effects of ACR induced neurotoxicity.
ACR: acrylamide; NOAEL: no-observed-adverse-effect limit; LOAEL: lowest observed adverse effect level; BMDL: benchmark dose lower confidence limit; PAM: polyacrylamide; CYPs: Cytochrome; GA: glycidamide; CNS: central nervous system; PNS: peripheral nervous system; MT: melatonin; GSH: glutathione; SOD: superoxide dismutase; CAT: catalase; SH: bisulfide; NH2: azanide; OH: hydroxide; NT: neurotransmitters; TBA: thiobarbituric acid; LA: linolenic acid; PUFA: polyunsaturated fatty acids; GST: glutathione S-transferase; MDA: malondialdehyde; DNPH: dinitrophenylhydrazine; TERT: telomerase reverse transcriptase; ROS: reactive oxygen species; GFAP: glial fibrillary acidic protein; TBARS: thiobarbituric acid reactive substance; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling; AChE: acetylcholinesterase; DA: dopamine; Bcl2: B-cell lymphoma 2; MAPK: mitogen-activated protein kinase; TNF: tumour necrosis factor; LPO: lipid peroxidation; NF-kB: nuclear factor kappa B; Keap-1: Kelch-like ECH-associated protein 1; TH: tyrosine hydroxylase; DOPA: 3,4-dihydroxyphenylalanine; BBB: blood brain barrier; AD: Alzheimer’s disease; PD: Parkinson’s disease; HD: Huntington’s disease; ALS: amyotrophic lateral sclerosis; and MS: multiple sclerosis.
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
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\n\n2. SUBMIT YOUR MANUSCRIPT
\n\nAfter approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
\n\n3. PEER REVIEW RESULTS
\n\nExternal reviewers will evaluate your manuscript and provide you with their feedback. You may be asked to revise your draft, or parts of your draft, provide additional information and make any other necessary changes according to their comments and suggestions.
\n\n4. ACCEPTANCE AND PRICE QUOTE
\n\nIf the manuscript is formally accepted after peer review you will receive a formal Notice of Acceptance, and a price quote.
\n\nThe Open Access Publishing Fee of your IntechOpen Compacts, Monograph or Edited Book depends on the volume of the publication and includes: project management, editorial and peer review services, technical editing, language copyediting, cover design and book layout, book promotion and ISBN assignment.
\n\nWe will send you your price quote and after it has been accepted (by both the author and the publisher), both parties will sign a Statement of Work binding them to adhere to the agreed upon terms.
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\n\nIf you feel that IntechOpen Compacts, Monographs or Edited Books are the right publishing format for your work, please fill out the publishing proposal form. For any specific queries related to the publishing process, or IntechOpen Compacts, Monographs & Edited Books in general, please contact us at book.department@intechopen.com
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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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This has compromised the ability of the environment to foster life and render its intrinsic values. Heavy metals are known to be naturally occurring compounds, but anthropogenic activities introduce them in large quantities in different environmental compartments. This leads to the environment’s ability to foster life being reduced as human, animal, and plant health become threatened. This occurs due to bioaccumulation in the food chains as a result of the nondegradable state of the heavy metals. Remediation of heavy metals requires special attention to protect soil quality, air quality, water quality, human health, animal health, and all spheres as a collection. Developed physical and chemical heavy metal remediation technologies are demanding costs which are not feasible, time-consuming, and release additional waste to the environment. This chapter summarises the problems related to heavy metal pollution and various remediation technologies. A case study in South Africa mines were also used.",book:{id:"6534",slug:"heavy-metals",title:"Heavy Metals",fullTitle:"Heavy Metals"},signatures:"Vhahangwele Masindi and Khathutshelo L. Muedi",authors:[{id:"225304",title:"Dr.",name:"Vhahangwele",middleName:null,surname:"Masindi",slug:"vhahangwele-masindi",fullName:"Vhahangwele Masindi"},{id:"241403",title:"M.Sc.",name:"Khathutshelo",middleName:"Lilith",surname:"Muedi",slug:"khathutshelo-muedi",fullName:"Khathutshelo Muedi"}]},{id:"46243",doi:"10.5772/57255",title:"Corrosion Inhibitors – Principles, Mechanisms and Applications",slug:"corrosion-inhibitors-principles-mechanisms-and-applications",totalDownloads:13693,totalCrossrefCites:40,totalDimensionsCites:159,abstract:null,book:{id:"3817",slug:"developments-in-corrosion-protection",title:"Developments in Corrosion Protection",fullTitle:"Developments in Corrosion Protection"},signatures:"Camila G. Dariva and Alexandre F. Galio",authors:[{id:"169261",title:"Dr.",name:"Camila",middleName:"G.",surname:"Dariva",slug:"camila-dariva",fullName:"Camila Dariva"},{id:"170138",title:"Dr.",name:"Alexandre",middleName:"Ferreira",surname:"Galio",slug:"alexandre-galio",fullName:"Alexandre Galio"}]},{id:"44359",doi:"10.5772/56197",title:"Microstructure and Mechanical Properties of High Strength Two-Phase Titanium Alloys",slug:"microstructure-and-mechanical-properties-of-high-strength-two-phase-titanium-alloys",totalDownloads:10278,totalCrossrefCites:55,totalDimensionsCites:127,abstract:null,book:{id:"3494",slug:"titanium-alloys-advances-in-properties-control",title:"Titanium Alloys",fullTitle:"Titanium Alloys - Advances in Properties Control"},signatures:"J. Sieniawski, W. Ziaja, K. Kubiak and M. Motyka",authors:[{id:"101690",title:"Associate Prof.",name:"Maciej",middleName:null,surname:"Motyka",slug:"maciej-motyka",fullName:"Maciej Motyka"},{id:"109232",title:"Prof.",name:"Jan",middleName:null,surname:"Sieniawski",slug:"jan-sieniawski",fullName:"Jan Sieniawski"}]},{id:"46882",doi:"10.5772/58534",title:"Additive Manufacturing of Al Alloys and Aluminium Matrix Composites (AMCs)",slug:"additive-manufacturing-of-al-alloys-and-aluminium-matrix-composites-amcs-",totalDownloads:10093,totalCrossrefCites:52,totalDimensionsCites:117,abstract:null,book:{id:"3844",slug:"light-metal-alloys-applications",title:"Light Metal Alloys Applications",fullTitle:"Light Metal Alloys Applications"},signatures:"Diego Manfredi, Flaviana Calignano, Manickavasagam Krishnan,\nRiccardo Canali, Elisa Paola Ambrosio, Sara Biamino, Daniele Ugues,\nMatteo Pavese and Paolo Fino",authors:[{id:"16648",title:"Dr.",name:"Diego",middleName:null,surname:"Manfredi",slug:"diego-manfredi",fullName:"Diego Manfredi"},{id:"18978",title:"Dr.",name:"Matteo",middleName:null,surname:"Pavese",slug:"matteo-pavese",fullName:"Matteo Pavese"},{id:"19187",title:"Dr.",name:"Sara",middleName:null,surname:"Biamino",slug:"sara-biamino",fullName:"Sara Biamino"},{id:"19188",title:"Dr.",name:"Elisa",middleName:null,surname:"Ambrosio",slug:"elisa-ambrosio",fullName:"Elisa Ambrosio"},{id:"19189",title:"Dr.",name:"Paolo",middleName:null,surname:"Fino",slug:"paolo-fino",fullName:"Paolo Fino"},{id:"170227",title:"Dr.",name:"Flaviana",middleName:null,surname:"Calignano",slug:"flaviana-calignano",fullName:"Flaviana Calignano"},{id:"170228",title:"MSc.",name:"Riccardo",middleName:null,surname:"Canali",slug:"riccardo-canali",fullName:"Riccardo Canali"},{id:"170229",title:"MSc.",name:"Manickavasagam",middleName:null,surname:"Krishnan",slug:"manickavasagam-krishnan",fullName:"Manickavasagam Krishnan"}]}],mostDownloadedChaptersLast30Days:[{id:"70661",title:"Bioremediation Techniques for Polluted Environment: Concept, Advantages, Limitations, and Prospects",slug:"bioremediation-techniques-for-polluted-environment-concept-advantages-limitations-and-prospects",totalDownloads:2538,totalCrossrefCites:9,totalDimensionsCites:24,abstract:"Environmental pollution has been rising in the past few decades due to increased anthropogenic activities. Bioremediation is an attractive and successful cleaning technique to remove toxic waste from polluted environment. Bioremediation is highly involved in degradation, eradication, immobilization, or detoxification diverse chemical wastes and physical hazardous materials from the surrounding through the all-inclusive and action of microorganisms. The main principle is degrading and converting pollutants to less toxic forms. Bioremediation can be carried out ex-situ and in-situ, depending on several factors, which include but not limited to cost, site characteristics, type, and concentration of pollutants. Hence, appropriate bioremediation technique is selected. Additionally, the major methodologies to develop bioremediation are biostimulation, bioaugmentation, bioventing, biopiles, and bioattenuation provided the environmental factors that decide the completion of bioremediation. Bioremediation is the most effective, economical, eco-friendly management tool to manage the polluted environment. All bioremediation techniques have its own advantage and disadvantage because it has its own specific applications.",book:{id:"9343",slug:"trace-metals-in-the-environment-new-approaches-and-recent-advances",title:"Trace Metals in the Environment",fullTitle:"Trace Metals in the Environment - New Approaches and Recent Advances"},signatures:"Indu Sharma",authors:[{id:"301262",title:"Associate Prof.",name:"Indu",middleName:null,surname:"Sharma",slug:"indu-sharma",fullName:"Indu Sharma"}]},{id:"60680",title:"Environmental Contamination by Heavy Metals",slug:"environmental-contamination-by-heavy-metals",totalDownloads:16114,totalCrossrefCites:178,totalDimensionsCites:384,abstract:"The environment and its compartments have been severely polluted by heavy metals. This has compromised the ability of the environment to foster life and render its intrinsic values. Heavy metals are known to be naturally occurring compounds, but anthropogenic activities introduce them in large quantities in different environmental compartments. This leads to the environment’s ability to foster life being reduced as human, animal, and plant health become threatened. This occurs due to bioaccumulation in the food chains as a result of the nondegradable state of the heavy metals. Remediation of heavy metals requires special attention to protect soil quality, air quality, water quality, human health, animal health, and all spheres as a collection. Developed physical and chemical heavy metal remediation technologies are demanding costs which are not feasible, time-consuming, and release additional waste to the environment. This chapter summarises the problems related to heavy metal pollution and various remediation technologies. A case study in South Africa mines were also used.",book:{id:"6534",slug:"heavy-metals",title:"Heavy Metals",fullTitle:"Heavy Metals"},signatures:"Vhahangwele Masindi and Khathutshelo L. Muedi",authors:[{id:"225304",title:"Dr.",name:"Vhahangwele",middleName:null,surname:"Masindi",slug:"vhahangwele-masindi",fullName:"Vhahangwele Masindi"},{id:"241403",title:"M.Sc.",name:"Khathutshelo",middleName:"Lilith",surname:"Muedi",slug:"khathutshelo-muedi",fullName:"Khathutshelo Muedi"}]},{id:"59905",title:"Synthesis of Silver Nanoparticles",slug:"synthesis-of-silver-nanoparticles",totalDownloads:6825,totalCrossrefCites:9,totalDimensionsCites:18,abstract:"Nanoparticles of noble metals, especially the silver nanoparticles, have been widely used in different fields of science. Their unique properties, which can be incorporated into biosensor materials, composite fibers, cosmetic products, antimicrobial applications, conducting materials and electronic components, make them a very important subject to be studied by chemistry, biology, healthcare, electronic and other related branches. These unique properties depend upon size and shape of the silver nanoparticles. Different preparation methods have been reported for the synthesis of the silver nanoparticles, such as electron irradiation, laser ablation, chemical reduction, biological artificial methods, photochemical methods and microwave processing. This chapter aims to inform the synthesis methods of the silver nanoparticles.",book:{id:"6552",slug:"silver-nanoparticles-fabrication-characterization-and-applications",title:"Silver Nanoparticles",fullTitle:"Silver Nanoparticles - Fabrication, Characterization and Applications"},signatures:"Remziye Güzel and Gülbahar Erdal",authors:[{id:"226613",title:"Dr.",name:"Remziye",middleName:null,surname:"Güzel",slug:"remziye-guzel",fullName:"Remziye Güzel"},{id:"240772",title:"MSc.",name:"Gülbahar",middleName:null,surname:"Erdal",slug:"gulbahar-erdal",fullName:"Gülbahar Erdal"}]},{id:"71326",title:"Stability of Metal Complexes",slug:"stability-of-metal-complexes",totalDownloads:2314,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"The stability of coordination complex is an important factor that decides the stability and reactivity of a metal complex. The stability of metal complex is governed by two different aspects such as thermodynamic and kinetic stabilities. The correlation between stability and reactivity of coordination compounds has been described in this chapter. This chapter also enlists the factors influencing the stability of metal complexes such as the nature of metal ions, ligands, bonding between metal ions and ligands, etc. In addition, the methods available for the determination of stability constants are given in detail.",book:{id:"9190",slug:"stability-and-applications-of-coordination-compounds",title:"Stability and Applications of Coordination Compounds",fullTitle:"Stability and Applications of Coordination Compounds"},signatures:"Senthilkumar Muthaiah, Anita Bhatia and Muthukumar Kannan",authors:null},{id:"60518",title:"Synthetic Methods for Titanium Dioxide Nanoparticles: A Review",slug:"synthetic-methods-for-titanium-dioxide-nanoparticles-a-review",totalDownloads:5208,totalCrossrefCites:29,totalDimensionsCites:53,abstract:"Titanium dioxide (TiO2) semiconductor nanoparticles are one kind of important and promising photocatalysts in photocatalysis because of their unique optical and electronic properties. Their properties, which are determined by the preparation method, are very crucial in photocatalysis. In this chapter, an overview was carried out on the different methods that are used or have been used to prepare titanium dioxide nanoparticles. There are various methods that can be used to synthesize TiO2 and the most commonly used methods include sol-gel process, chemical vapor deposition (CVD) and hydrothermal method among others. This review will focus on selected preparation methods of titanium dioxide photocatalyst.",book:{id:"6426",slug:"titanium-dioxide-material-for-a-sustainable-environment",title:"Titanium Dioxide",fullTitle:"Titanium Dioxide - Material for a Sustainable Environment"},signatures:"Pardon Nyamukamba, Omobola Okoh, Henry Mungondori,\nRaymond Taziwa and Simcelile Zinya",authors:[{id:"196100",title:"Dr.",name:"Raymond",middleName:null,surname:"Taziwa",slug:"raymond-taziwa",fullName:"Raymond Taziwa"},{id:"219920",title:"Prof.",name:"Omobola",middleName:null,surname:"Okoh",slug:"omobola-okoh",fullName:"Omobola Okoh"},{id:"226567",title:"Dr.",name:"Pardon",middleName:null,surname:"Nyamukamba",slug:"pardon-nyamukamba",fullName:"Pardon Nyamukamba"},{id:"239758",title:"Mr.",name:"Simcelile",middleName:null,surname:"Zinya",slug:"simcelile-zinya",fullName:"Simcelile Zinya"}]}],onlineFirstChaptersFilter:{topicId:"158",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81781",title:"Experimental Investigation of Mechanical and Wear Behaviour of AZ91 Magnesium Hybrid Composite Materials",slug:"experimental-investigation-of-mechanical-and-wear-behaviour-of-az91-magnesium-hybrid-composite-mater",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.104703",abstract:"In recent years, emerging requisite for advanced materials gave a path for hybrid composites. Magnesium metal matrix composites are gaining more interest and a better substitute for heavier steel, aluminium, titanium and even for plastic based materials. At present the AZ91 magnesium alloy is most widely in transport vehicle industry. However, the application of AZ91 magnesium alloys are limited due to several negative effects such as poor creep resistance, wear resistance and inferior corrosion resistance when it is exposed to atmospheric conditions. Future to improve the strength, better corrosion resistance and wear resistance are important for their extend applications of exciting alloy AZ91. The main objective of the present investigation is to achieve above mentioned properties. The AZ91 alloy was reinforced with titanium dioxide/0.5% graphene and with titanium/0.5% graphene in varying weight percentage (1%, 2%) by stir casting technique. These combinations are called hybrid metal matrix composite of materials such as AZ91 + 1%Ti +0.5% Gr (A1), AZ91 + 2%Ti +0.5% Gr (A2), AZ91 + 1%TiO2 + 0.5% Gr (B1) and AZ91 + 2%TiO2 + 0.5% Gr (B2) alloys. The following experiments such as tensile, compressive, hardness and wear tests have been carried out to find all the properties from the newly developed hybrid metal matrix composite of materials and compared with AZ91. Wear tests have been carried out by pin on disc tribometer for both dry and wet sliding condition under 20 N,40 N,60 N, and 80 N. The results indicated the AZ91–1%TiO2–0.5%Gr having high wear resistance compared to other three combinations as well as AZ91. The present experimental investigations of hybrid metal matrix composite of materials have wear resistance in the order of B1 > A2 > A1 > B2 > AZ91 and AZ91–2%TiO2–0.5% Gr showed good tensile strength and hardness. The enhanced these properties were discussed in this paper.",book:{id:"11208",title:"Current Trends in Magnesium (Mg) Research",coverURL:"https://cdn.intechopen.com/books/images_new/11208.jpg"},signatures:"Palanivel Mathiazhagan and S. Jayabharathy"},{id:"81709",title:"New-Age Al-Cu-Mn-Zr (ACMZ) Alloy for High Temperature-High Strength Applications: A Review",slug:"new-age-al-cu-mn-zr-acmz-alloy-for-high-temperature-high-strength-applications-a-review",totalDownloads:17,totalDimensionsCites:0,doi:"10.5772/intechopen.104533",abstract:"One of the prime challenges with age hardened Al-Cu alloys is the strength degradation at high temperatures (above ∼250°C) due to the coarsening of strengthening θ′ precipitates and associated metastable θ′ → stable θ phase transformation. A recent discovery suggests that micro-alloying with Manganese (Mn) and Zirconium (Zr) can synergistically restrict θ′ precipitate coarsening, thereby rendering an excellent high temperature stability for Al-Cu-Mn-Zr (ACMZ) alloys. The θ′ precipitates are stabilized primarily from the reduction of interfacial energy by preferential solute segregation (Mn & Zr) at θ′ precipitate/α-Al matrix interfaces. The Al-Cu-Mn-Zr alloys thereby exhibit excellent high temperature hardness and tensile properties (yield and ultimate tensile strength) in addition to superior fatigue life and creep resistance. This newly developed Al-Cu-Mn-Zr alloys also showed excellent hot tearing resistance compared to the conventional cast Al-Cu alloys so much so that it meets the industrial standards as well. These alloys also have promising manufacturing possibility by additive route. Overall, Al-Cu-Mn-Zr alloys offer great potential for the automotive industry because of their unprecedented high temperature performance which should enable engineers to build light weight passenger vehicles leading to a safer and greener environment.",book:{id:"10847",title:"Aluminium Alloys - Design and Development of Innovative Alloys, Manufacturing Processes and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10847.jpg"},signatures:"Samarendra Roy and Shibayan Roy"},{id:"81342",title:"Magnesium Borates: The Relationship between the Characteristics, Properties, and Novel Technologies",slug:"magnesium-borates-the-relationship-between-the-characteristics-properties-and-novel-technologies",totalDownloads:25,totalDimensionsCites:0,doi:"10.5772/intechopen.104487",abstract:"Magnesium borates are compounds including mainly magnesium (Mg), boron (B) oxygen (O), and hydrogen (H). Magnesium borates are traditionally famous for their strong thermoluminescence, mechanical and thermal features due to their high elasticity coefficient, corrosion, and heat resistance. Because of being beneficial, especially in the applications such as thermoluminescence and X-ray screening, and ease of synthesis, magnesium borates are produced by using different experimental procedures exhibiting different characteristics. Main traditional synthesis techniques can be classified as liquid state and solid-state synthesis methods. With the help of novelties in synthesis technology, new techniques are beginning to emerge in magnesium borate syntheses such as hybrid synthesis, ultrasound, microwave, and capping agent addition. The strengthened characteristics of the compounds would lead to new applications such as stomach cancer chemotherapy and wastewater treatment. In this chapter, it is aimed to make a comparison between the characteristics of synthesized magnesium borates and their properties. In addition, new types of magnesium borates obtained by various synthetic techniques are expected to be useful for industrial applications such as space technology, radiation dosimetry, X-ray screening, ion batteries, and hydrocarbon reaction catalysis. Such classification of properties and the synthesis techniques will enlighten the relationship between the characteristics and novel applications of magnesium borates.",book:{id:"11208",title:"Current Trends in Magnesium (Mg) Research",coverURL:"https://cdn.intechopen.com/books/images_new/11208.jpg"},signatures:"Fatma Tugce Senberber Dumanli"},{id:"81125",title:"Magnesium Alloys for Sustainable Weight-Saving Approach: A Brief Market Overview, New Trends, and Perspectives",slug:"magnesium-alloys-for-sustainable-weight-saving-approach-a-brief-market-overview-new-trends-and-persp",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.102777",abstract:"In the transportation sector, weight-saving strategies emphasize greenhouse gas reductions by improving fuel efficiency. Furthermore, it is a fact that consumers appreciate less-consuming vehicles. Lighter battery electric vehicles (BEV) mean higher travel distance covered with the same battery charge. Still, the fuel range of BEV is today not a secondary issue for choosing an e-vehicle as a unique family vehicle. Weight-saving strategies are also a priority for hydrogen gas-fuelled vehicles. Until hydrogen fuel for the transport sector is not produced at affordable costs in fully renewable pathways, increased fuel efficiency is critical for the product appeal. Magnesium is an environmentally compatible and biodegradable material with a similar density to structural plastics. On the contrary, plastics are responsible for nonbiodegradable microplastics in deep-marine environments when not recycled or correctly treated at their end of life. Due to the costly usage of lightweight materials, priority is given to activities to reduce costs by developing new materials and increasing the affordability of manufacturing costs. In this chapter, magnesium is presented from much perspective point of view: we will base it on comprehension of the past, considering the present, but with some ambition to propel hearts over today’s obstacles.",book:{id:"11208",title:"Current Trends in Magnesium (Mg) Research",coverURL:"https://cdn.intechopen.com/books/images_new/11208.jpg"},signatures:"Fabrizio D’Errico, Martin Tauber and Michael Just"},{id:"80372",title:"Application of the Aluminothermic Reduction Process for Magnesium Removal in Aluminum Scrap",slug:"application-of-the-aluminothermic-reduction-process-for-magnesium-removal-in-aluminum-scrap",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.102407",abstract:"Magnesium is considered as impurity element in aluminum recycled for obtaining some cast alloys, with low concentration Mg, because at 0.1 wt% results in fragility, fractures, and defects. This research applies the aluminothermic reduction process to decrease magnesium content in aluminum cans by adding ZnO, to produce reaction products solid-state (Al2O3, MgO and MgAl2O4), and there is a possibility to obtain Al-Zn alloy. The conditions of the process were, melting temperature (750, 800, 850°C) and stirring velocity (200, 250, 300 rpm). The Mg and Zn contents were measured for chemical analysis and scrap generated from every process was analyzed by X-ray diffraction. The results show how the aluminothermic reduction decreased Mg from 0.93 to 0.06 wt% and increased zinc up to 5.52wt % in the molten metal. Therefore, this process can be used to remove Mg and can also prevent the generation of polluting gases into the environment.",book:{id:"10847",title:"Aluminium Alloys - Design and Development of Innovative Alloys, Manufacturing Processes and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10847.jpg"},signatures:"Rocio Maricela Ochoa Palacios, Citlaly Castillo Rodriguez, Jesus Torres Torres, Perla Janet Resendiz Hernandez and Alfredo Flores Valdes"},{id:"80920",title:"Drilling of 7075 Aluminum Alloys",slug:"drilling-of-7075-aluminum-alloys",totalDownloads:51,totalDimensionsCites:0,doi:"10.5772/intechopen.102864",abstract:"Aluminum alloy (Al 7075) has been increasingly used as structural components in automotive and aerospace industry due to their low density, high strength and good corrosion resistance compared with other metals. To manufacture and assemble the components, drilling operations are often conducted. However, Al 7075 is ductile and soft, which causes difficulty in drilling, resulting in material adhesion, high tool wear, short tool life and poor hole quality. As a result of the poor hole quality, there is a high percentage of part rejection, which can increase the manufacturing time and cost. This chapter discusses challenges and techniques to drill Al 7075 in terms of the cutting parameters and drilling conditions to prolong the tool life and achieve good hole quality. Drilling experiments on Al 7075-T6 (heat-treated) were conducted using carbide cutting tools at various cutting parameters. Reducing cutting speed and increasing feed rate resulted in reducing tool wear, whereas a reduction in surface roughness, hence improved machined surface finish, was found when both cutting speed and feed rate were reduced in drilling Al 7075-T6. Producing good hole quality is vital during the drilling process to ensure a good assembly and product service performance.",book:{id:"10847",title:"Aluminium Alloys - Design and Development of Innovative Alloys, Manufacturing Processes and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10847.jpg"},signatures:"Aishah Najiah Dahnel, Mohamad Noor Ikhwan Naiman, Muhammad Azim Mirza Mohd Farid, Ahmad Faris Abdul Rahman and Nur Munirah Meera Mydin"}],onlineFirstChaptersTotal:13},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with the environment and promote the use of adequate management practices such as those outlined in the United Nations’ Sustainable Development Goals.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",keywords:"Anthropic effects, Overexploitation, Biodiversity loss, Degradation, Inadequate Management, SDGs adequate practices"},{id:"38",title:"Pollution",scope:"\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",keywords:"Human activity, Pollutants, Reduced risks, Population growth, Waste disposal, Remediation, Clean environment"},{id:"41",title:"Water Science",scope:"