\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"1860",leadTitle:null,fullTitle:"Fourier Transform - Signal Processing",title:"Fourier Transform",subtitle:"Signal Processing",reviewType:"peer-reviewed",abstract:"The field of signal processing has seen explosive growth during the past decades; almost all textbooks on signal processing have a section devoted to the Fourier transform theory. For this reason, this book focuses on the Fourier transform applications in signal processing techniques. The book chapters are related to DFT, FFT, OFDM, estimation techniques and the image processing techqniques. It is hoped that this book will provide the background, references and the incentive to encourage further research and results in this area as well as provide tools for practical applications. It provides an applications-oriented to signal processing written primarily for electrical engineers, communication engineers, signal processing engineers, mathematicians and graduate students will also find it useful as a reference for their research activities.",isbn:null,printIsbn:"978-953-51-0453-7",pdfIsbn:"978-953-51-6195-0",doi:"10.5772/813",price:139,priceEur:155,priceUsd:179,slug:"fourier-transform-signal-processing",numberOfPages:368,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"b8f6c94b687a4f0351f2e8d961e35275",bookSignature:"Salih Mohammed Salih",publishedDate:"April 11th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/1860.jpg",numberOfDownloads:65537,numberOfWosCitations:30,numberOfCrossrefCitations:31,numberOfCrossrefCitationsByBook:3,numberOfDimensionsCitations:44,numberOfDimensionsCitationsByBook:3,hasAltmetrics:0,numberOfTotalCitations:105,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 11th 2011",dateEndSecondStepPublish:"June 8th 2011",dateEndThirdStepPublish:"October 13th 2011",dateEndFourthStepPublish:"November 12th 2011",dateEndFifthStepPublish:"March 11th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",middleName:"Mohammed",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih",profilePictureURL:"https://mts.intechopen.com/storage/users/111691/images/system/111691.jpg",biography:"Salih Mohammed Salih (Member IEEE) was born in Babylon-1970, Iraq. He received the B.Sc. degree in Electrical Department from the University of Baghdad (1999)-Iraq, M.Sc. and Ph.D. degrees in Communication Engineering from the University of Technology-Iraq in 2003 and 2008 respectively, Since 2005, he has been with the University of Anbar-Iraq, where he is lecturer in Electrical Engineering Department. His research interests include: MC-CDMA, OFDM, MIMO-OFDM, CDMA, Modulation Techniques, Security, Wireless Communication, Radar, and Computer Networks, and renewable Energy Resources. He completed part of his Ph.D. research in MC-CDMA at the National Technical University of Athens.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"University of Anbar",institutionURL:null,country:{name:"Iraq"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"756",title:"Power Electronics",slug:"power-electronics"}],chapters:[{id:"35213",title:"Interpolation Algorithms of DFT for Parameters Estimation of Sinusoidal and Damped Sinusoidal Signals",doi:"10.5772/36264",slug:"interpolated-dft",totalDownloads:3359,totalCrossrefCites:12,totalDimensionsCites:15,hasAltmetrics:0,abstract:null,signatures:"Krzysztof Duda",downloadPdfUrl:"/chapter/pdf-download/35213",previewPdfUrl:"/chapter/pdf-preview/35213",authors:[{id:"107676",title:"Dr.",name:"Krzysztof",surname:"Duda",slug:"krzysztof-duda",fullName:"Krzysztof Duda"}],corrections:null},{id:"35214",title:"A proposed Model-Based Adaptive System for DFT Coefficients Estimation Using SIMULINK",doi:"10.5772/35469",slug:"a-proposed-model-based-adaptive-system-for-dft-coefficients-estimation",totalDownloads:4925,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Omar Mustaf",downloadPdfUrl:"/chapter/pdf-download/35214",previewPdfUrl:"/chapter/pdf-preview/35214",authors:[{id:"104590",title:"Ph.D.",name:"Omar",surname:"Mustaf",slug:"omar-mustaf",fullName:"Omar Mustaf"}],corrections:null},{id:"35215",title:"FFT-Based Efficient Algorithms for Time Delay Estimation",doi:"10.5772/36242",slug:"efficient-algorithm-for-time-delay-estimation",totalDownloads:4962,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Renbiao Wu, Wenyi Wang and Qiongqiong Jia",downloadPdfUrl:"/chapter/pdf-download/35215",previewPdfUrl:"/chapter/pdf-preview/35215",authors:[{id:"107618",title:"Prof.",name:"Renbiao",surname:"Wu",slug:"renbiao-wu",fullName:"Renbiao Wu"}],corrections:null},{id:"35216",title:"Channel Identification for OFDM Communication System in Frequency Domain",doi:"10.5772/36191",slug:"channel-identification-for-ofdm-communication-system-in-frequency-domain",totalDownloads:2380,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Lianming Sun",downloadPdfUrl:"/chapter/pdf-download/35216",previewPdfUrl:"/chapter/pdf-preview/35216",authors:[{id:"107426",title:"Dr.",name:"Lianming",surname:"Sun",slug:"lianming-sun",fullName:"Lianming Sun"}],corrections:null},{id:"35217",title:"Fast Fourier Transform Processors: Implementing FFT and IFFT Cores for OFDM Communication Systems",doi:"10.5772/36176",slug:"fast-fourier-transform-processors-implementing-fft-and-ifft-cores-for-ofdm-communication-systems",totalDownloads:10702,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"A. Cortes, I. Velez, M. Turrillas and J. F. Sevillano",downloadPdfUrl:"/chapter/pdf-download/35217",previewPdfUrl:"/chapter/pdf-preview/35217",authors:[{id:"107354",title:"Dr.",name:"Ainhoa",surname:"Cortes",slug:"ainhoa-cortes",fullName:"Ainhoa Cortes"},{id:"114188",title:"Dr.",name:"Igone",surname:"Velez",slug:"igone-velez",fullName:"Igone Velez"},{id:"114189",title:"Dr.",name:"Juan Francisco",surname:"Sevillano",slug:"juan-francisco-sevillano",fullName:"Juan Francisco Sevillano"},{id:"127891",title:"Ms.",name:"Marta",surname:"Turrillas",slug:"marta-turrillas",fullName:"Marta Turrillas"}],corrections:null},{id:"35218",title:"FPGA Implementation of Inverse Fast Fourier Transform in Orthogonal Frequency Division Multiplexing Systems",doi:"10.5772/36664",slug:"fpga-implementation-of-inverse-fast-fourier-transform-in-orthogonal-frequency-division-multiplexing-",totalDownloads:5668,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Somayeh Mohammady, Nasri Sulaiman, Roslina M. Sidek, Pooria Varahram, and M. Nizar Hamidon",downloadPdfUrl:"/chapter/pdf-download/35218",previewPdfUrl:"/chapter/pdf-preview/35218",authors:[{id:"109280",title:"Dr.",name:"Somayeh",surname:"Mohammady",slug:"somayeh-mohammady",fullName:"Somayeh Mohammady"}],corrections:null},{id:"35219",title:"Fault Diagnosis of Induction Motors Based on FFT",doi:"10.5772/37419",slug:"fault-diagnosis-of-induction-motors-based-on-fft",totalDownloads:7893,totalCrossrefCites:6,totalDimensionsCites:8,hasAltmetrics:0,abstract:null,signatures:"Castelli Marcelo, Juan Pablo Fossatti and Jose Ignacio Terra",downloadPdfUrl:"/chapter/pdf-download/35219",previewPdfUrl:"/chapter/pdf-preview/35219",authors:[{id:"112666",title:"Dr.",name:"Marcelo",surname:"Castelli",slug:"marcelo-castelli",fullName:"Marcelo Castelli"}],corrections:null},{id:"35220",title:"Non-Parametric Estimation of the Periodic Signal Parameters in the Frequency Domain",doi:"10.5772/36168",slug:"non-parametric-estimation-of-the-periodic-signal-parameters-in-the-frequency-domain",totalDownloads:2799,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Dusan Agrez",downloadPdfUrl:"/chapter/pdf-download/35220",previewPdfUrl:"/chapter/pdf-preview/35220",authors:[{id:"107330",title:"Prof.",name:"Dusan",surname:"Agrez",slug:"dusan-agrez",fullName:"Dusan Agrez"}],corrections:null},{id:"35221",title:"A Reformulative Retouch on the Fourier Transform – “Unprincipled” Uncertainty Principle",doi:"10.5772/35832",slug:"a-reformulative-retouch-on-the-fourier-transform",totalDownloads:2167,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Csaba Szantay, Jr.",downloadPdfUrl:"/chapter/pdf-download/35221",previewPdfUrl:"/chapter/pdf-preview/35221",authors:[{id:"106016",title:"Prof.",name:"Csaba",surname:"Szántay Jr.",slug:"csaba-szantay-jr.",fullName:"Csaba Szántay Jr."}],corrections:null},{id:"35222",title:"Aspects of Using Chirp Excitation for Estimation of Bioimpedance Spectrum",doi:"10.5772/37315",slug:"aspects-of-using-chirp-excitation-for-estimation-of-bioimpedance-spectrum",totalDownloads:3639,totalCrossrefCites:5,totalDimensionsCites:9,hasAltmetrics:0,abstract:null,signatures:"Toivo Paavle, Mart Min and Toomas Parve",downloadPdfUrl:"/chapter/pdf-download/35222",previewPdfUrl:"/chapter/pdf-preview/35222",authors:[{id:"112220",title:"Dr.",name:"Toivo",surname:"Paavle",slug:"toivo-paavle",fullName:"Toivo Paavle"}],corrections:null},{id:"35223",title:"Simple Signals for System Identification",doi:"10.5772/35697",slug:"system-identification-simplified",totalDownloads:3812,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Paul Annus, Raul Land, Mart Min and Jaan Ojarand",downloadPdfUrl:"/chapter/pdf-download/35223",previewPdfUrl:"/chapter/pdf-preview/35223",authors:[{id:"105504",title:"Dr.",name:"Paul",surname:"Annus",slug:"paul-annus",fullName:"Paul Annus"}],corrections:null},{id:"35224",title:"Invariant Nonlinear Correlations via Fourier Transform",doi:"10.5772/37027",slug:"invariant-nonlinear-correlations-via-fourier-transform",totalDownloads:3380,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Angel Coronel-Beltran and Josue Alvarez-Borrego",downloadPdfUrl:"/chapter/pdf-download/35224",previewPdfUrl:"/chapter/pdf-preview/35224",authors:[{id:"103367",title:"Prof.",name:"Josué",surname:"Álvarez-Borrego",slug:"josue-alvarez-borrego",fullName:"Josué Álvarez-Borrego"},{id:"110901",title:"Dr.",name:"Angel",surname:"Coronel-Beltrán",slug:"angel-coronel-beltran",fullName:"Angel Coronel-Beltrán"}],corrections:null},{id:"35225",title:"Pattern Recognition of Digital Images by One-Dimensional Signatures",doi:"10.5772/37371",slug:"pattern-recognition-of-digital-images-by-unidimensional-signatures",totalDownloads:3229,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Selene Solorza, Josue Alvarez-Borrego and Gildardo Chaparro-Magallanez",downloadPdfUrl:"/chapter/pdf-download/35225",previewPdfUrl:"/chapter/pdf-preview/35225",authors:[{id:"103367",title:"Prof.",name:"Josué",surname:"Álvarez-Borrego",slug:"josue-alvarez-borrego",fullName:"Josué Álvarez-Borrego"},{id:"113139",title:"Dr.",name:"Selene",surname:"Solorza",slug:"selene-solorza",fullName:"Selene Solorza"},{id:"113140",title:"MSc.",name:"Gildardo",surname:"Chaparro-Magallanez",slug:"gildardo-chaparro-magallanez",fullName:"Gildardo Chaparro-Magallanez"}],corrections:null},{id:"35226",title:"Vectorial Signatures for Pattern Recognition",doi:"10.5772/36964",slug:"vectorial-signatures-for-pattern-recognition",totalDownloads:2621,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Jesus Ramon Lerma-Aragon and Josue Alvarez-Borrego",downloadPdfUrl:"/chapter/pdf-download/35226",previewPdfUrl:"/chapter/pdf-preview/35226",authors:[{id:"103367",title:"Prof.",name:"Josué",surname:"Álvarez-Borrego",slug:"josue-alvarez-borrego",fullName:"Josué Álvarez-Borrego"},{id:"110629",title:"Dr.",name:"Jesus",surname:"Lerma Aragon",slug:"jesus-lerma-aragon",fullName:"Jesus Lerma Aragon"}],corrections:null},{id:"35227",title:"Multidimensional Features Extraction Methods in Frequency Domain",doi:"10.5772/36704",slug:"multidimensional-features-extraction-methods-in-frequency-domain",totalDownloads:4003,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Jesus Olivares-Mercado, Gualberto Aguilar-Torres, Karina Toscano-Medina, Gabriel Sanchez-Perez, Mariko Nakano-Miyatake and Hector Perez-Meana",downloadPdfUrl:"/chapter/pdf-download/35227",previewPdfUrl:"/chapter/pdf-preview/35227",authors:[{id:"30416",title:"Prof.",name:"Hector",surname:"Perez Meana",slug:"hector-perez-meana",fullName:"Hector Perez Meana"},{id:"46586",title:"Dr.",name:"Gualberto",surname:"Aguilar",slug:"gualberto-aguilar",fullName:"Gualberto Aguilar"},{id:"56517",title:"MSc.",name:"Jesús",surname:"Olivares",slug:"jesus-olivares",fullName:"Jesús Olivares"},{id:"109424",title:"Dr.",name:"Gabriel",surname:"Sanchez",slug:"gabriel-sanchez",fullName:"Gabriel Sanchez"},{id:"113946",title:"Dr.",name:"Mariko",surname:"Nakano Miyatake",slug:"mariko-nakano-miyatake",fullName:"Mariko Nakano Miyatake"},{id:"148981",title:"Dr.",name:"Karina",surname:"Toscano Medina",slug:"karina-toscano-medina",fullName:"Karina Toscano Medina"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2269",title:"Fourier Transform",subtitle:"Applications",isOpenForSubmission:!1,hash:"eef6992c6b1a91e721958aad15dd33c7",slug:"fourier-transform-applications",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2269.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4538",title:"Fourier Transform",subtitle:"Signal Processing and Physical Sciences",isOpenForSubmission:!1,hash:"4dfc78ab6a3abc41b6136a4a9e2b8afa",slug:"fourier-transform-signal-processing-and-physical-sciences",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/4538.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"848",title:"Lithium Ion Batteries",subtitle:"New Developments",isOpenForSubmission:!1,hash:"004acb03be77776b99046c8ce75985e0",slug:"lithium-ion-batteries-new-developments",bookSignature:"Ilias Belharouak",coverURL:"https://cdn.intechopen.com/books/images_new/848.jpg",editedByType:"Edited by",editors:[{id:"68750",title:"Dr.",name:"Ilias",surname:"Belharouak",slug:"ilias-belharouak",fullName:"Ilias Belharouak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5186",title:"Energy Management of Distributed Generation Systems",subtitle:null,isOpenForSubmission:!1,hash:"8163ec5236e181f2439394b698a33a40",slug:"energy-management-of-distributed-generation-systems",bookSignature:"Lucian Mihet-Popa",coverURL:"https://cdn.intechopen.com/books/images_new/5186.jpg",editedByType:"Edited by",editors:[{id:"28225",title:"Prof.",name:"Lucian",surname:"Mihet-Popa",slug:"lucian-mihet-popa",fullName:"Lucian Mihet-Popa"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"69",title:"Electric Machines and Drives",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"electric-machines-and-drives",bookSignature:"Miroslav Chomat",coverURL:"https://cdn.intechopen.com/books/images_new/69.jpg",editedByType:"Edited by",editors:[{id:"17405",title:"Dr.",name:"Miroslav",surname:"Chomat",slug:"miroslav-chomat",fullName:"Miroslav Chomat"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5168",title:"Alkali-ion Batteries",subtitle:null,isOpenForSubmission:!1,hash:"2ffb06f3e5dbad9167428c4c443e3a5e",slug:"alkali-ion-batteries",bookSignature:"Dongfang Yang",coverURL:"https://cdn.intechopen.com/books/images_new/5168.jpg",editedByType:"Edited by",editors:[{id:"177814",title:"Dr.",name:"Dongfang",surname:"Yang",slug:"dongfang-yang",fullName:"Dongfang Yang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3634",title:"Lithium-ion Batteries",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"lithium-ion-batteries",bookSignature:"Chong Rae Park",coverURL:"https://cdn.intechopen.com/books/images_new/3634.jpg",editedByType:"Edited by",editors:[{id:"7013",title:"Lithium-ion Batteries",name:"Chong Rae",surname:"Park",slug:"chong-rae-park",fullName:"Chong Rae Park"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5187",title:"Wireless Power Transfer",subtitle:"Fundamentals and Technologies",isOpenForSubmission:!1,hash:"2a20c1dde39792560dab996742f0e73c",slug:"wireless-power-transfer-fundamentals-and-technologies",bookSignature:"Eugen Coca",coverURL:"https://cdn.intechopen.com/books/images_new/5187.jpg",editedByType:"Edited by",editors:[{id:"5766",title:"Dr.",name:"Eugen",surname:"Coca",slug:"eugen-coca",fullName:"Eugen Coca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5835",title:"Development and Integration of Microgrids",subtitle:null,isOpenForSubmission:!1,hash:"f7816bff39f3662d16a4df91841e2b5b",slug:"development-and-integration-of-microgrids",bookSignature:"Wen-Ping Cao and Jin Yang",coverURL:"https://cdn.intechopen.com/books/images_new/5835.jpg",editedByType:"Edited by",editors:[{id:"174154",title:"Prof.",name:"Wenping",surname:"Cao",slug:"wenping-cao",fullName:"Wenping Cao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"81445",slug:"corrigendum-to-dermatoscopic-features-of-basal-cell-carcinoma",title:"Corrigendum to: Dermatoscopic Features of Basal Cell Carcinoma",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/81445.pdf",downloadPdfUrl:"/chapter/pdf-download/81445",previewPdfUrl:"/chapter/pdf-preview/81445",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/81445",risUrl:"/chapter/ris/81445",chapter:{id:"78974",slug:"dermatoscopic-features-of-basal-cell-carcinoma",signatures:"Tina Zagar, Nika Hlaca and Larisa Prpic-Massari",dateSubmitted:"July 9th 2021",dateReviewed:"September 10th 2021",datePrePublished:"October 15th 2021",datePublished:"March 23rd 2022",book:{id:"11014",title:"Dermatoscopy",subtitle:null,fullTitle:"Dermatoscopy",slug:"dermatoscopy",publishedDate:"March 23rd 2022",bookSignature:"Paweł Pietkiewicz",coverURL:"https://cdn.intechopen.com/books/images_new/11014.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"164394",title:"Ph.D.",name:"Paweł",middleName:"Piotr",surname:"Pietkiewicz",slug:"pawel-pietkiewicz",fullName:"Paweł Pietkiewicz"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"355350",title:"Prof.",name:"Larisa",middleName:null,surname:"Prpic-Massari",fullName:"Larisa Prpic-Massari",slug:"larisa-prpic-massari",email:"larisa.prpic@medri.uniri.hr",position:null,institution:null},{id:"355372",title:"Dr.",name:"Nika",middleName:null,surname:"Hlaca",fullName:"Nika Hlaca",slug:"nika-hlaca",email:"nika.hlaca@uniri.hr",position:null,institution:{name:"Klinički bolnički centar Rijeka",institutionURL:null,country:{name:"Croatia"}}},{id:"355373",title:"Dr.",name:"Tina",middleName:null,surname:"Zagar",fullName:"Tina Zagar",slug:"tina-zagar",email:"tinazagar89@gmail.com",position:null,institution:{name:"Klinički bolnički centar Rijeka",institutionURL:null,country:{name:"Croatia"}}}]}},chapter:{id:"78974",slug:"dermatoscopic-features-of-basal-cell-carcinoma",signatures:"Tina Zagar, Nika Hlaca and Larisa Prpic-Massari",dateSubmitted:"July 9th 2021",dateReviewed:"September 10th 2021",datePrePublished:"October 15th 2021",datePublished:"March 23rd 2022",book:{id:"11014",title:"Dermatoscopy",subtitle:null,fullTitle:"Dermatoscopy",slug:"dermatoscopy",publishedDate:"March 23rd 2022",bookSignature:"Paweł Pietkiewicz",coverURL:"https://cdn.intechopen.com/books/images_new/11014.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"164394",title:"Ph.D.",name:"Paweł",middleName:"Piotr",surname:"Pietkiewicz",slug:"pawel-pietkiewicz",fullName:"Paweł Pietkiewicz"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"355350",title:"Prof.",name:"Larisa",middleName:null,surname:"Prpic-Massari",fullName:"Larisa Prpic-Massari",slug:"larisa-prpic-massari",email:"larisa.prpic@medri.uniri.hr",position:null,institution:null},{id:"355372",title:"Dr.",name:"Nika",middleName:null,surname:"Hlaca",fullName:"Nika Hlaca",slug:"nika-hlaca",email:"nika.hlaca@uniri.hr",position:null,institution:{name:"Klinički bolnički centar Rijeka",institutionURL:null,country:{name:"Croatia"}}},{id:"355373",title:"Dr.",name:"Tina",middleName:null,surname:"Zagar",fullName:"Tina Zagar",slug:"tina-zagar",email:"tinazagar89@gmail.com",position:null,institution:{name:"Klinički bolnički centar Rijeka",institutionURL:null,country:{name:"Croatia"}}}]},book:{id:"11014",title:"Dermatoscopy",subtitle:null,fullTitle:"Dermatoscopy",slug:"dermatoscopy",publishedDate:"March 23rd 2022",bookSignature:"Paweł Pietkiewicz",coverURL:"https://cdn.intechopen.com/books/images_new/11014.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"164394",title:"Ph.D.",name:"Paweł",middleName:"Piotr",surname:"Pietkiewicz",slug:"pawel-pietkiewicz",fullName:"Paweł Pietkiewicz"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"12354",leadTitle:null,title:"Topics in Trauma Surgery",subtitle:null,reviewType:"peer-reviewed",abstract:"This book will be a self-contained collection of scholarly papers targeting an audience of practicing researchers, academics, PhD students and other scientists. The contents of the book will be written by multiple authors and edited by experts in the field.",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"87ab794acece5f66dca2ed70414ab85a",bookSignature:"",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12354.jpg",keywords:null,numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 10th 2022",dateEndSecondStepPublish:"May 31st 2022",dateEndThirdStepPublish:"July 30th 2022",dateEndFourthStepPublish:"October 18th 2022",dateEndFifthStepPublish:"December 17th 2022",remainingDaysToSecondStep:"11 days",secondStepPassed:!1,currentStepOfPublishingProcess:1,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:null},relatedBooks:[{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. Mauricio Barría",coverURL:"https://cdn.intechopen.com/books/images_new/6550.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. Mauricio Barría"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9500",title:"Recent Advances in Bone Tumours and Osteoarthritis",subtitle:null,isOpenForSubmission:!1,hash:"ea4ec0d6ee01b88e264178886e3210ed",slug:"recent-advances-in-bone-tumours-and-osteoarthritis",bookSignature:"Hiran Amarasekera",coverURL:"https://cdn.intechopen.com/books/images_new/9500.jpg",editedByType:"Edited by",editors:[{id:"67634",title:"Dr.",name:"Hiran",surname:"Amarasekera",slug:"hiran-amarasekera",fullName:"Hiran Amarasekera"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"70996",title:"Introductory Chapter: Mitochondrial Alterations and Neurological Disorders",doi:"10.5772/intechopen.91051",slug:"introductory-chapter-mitochondrial-alterations-and-neurological-disorders",body:'\n
Mitochondria (from Greek mito, μίτος, thread; and chondrion, χόνδριον, thick granule) are principal cell organelles, which participate in a wide spectrum of essential cellular functions, being the main energy providers for living eukaryotic cells, especially for neurons and glia, which are characterized by high metabolic activity and energy consumption.
\nThus, it is expectable that mitochondrial dysfunction, having pleotropic effect on the cell, may play a crucial role in a substantial number of serious neurological disorders including Alzheimer’s disease (AD) [1, 2], Parkinson’s disease (PD) [3] Huntington’s disease [4, 5], amyotrophic lateral sclerosis (ALS) [6], multiple sclerosis (MS) [7, 8], as well as some of the major psychiatric diseases [9], given that both, neurons and glia, are particularly sensitive and vulnerable to energy decline [10].
\nMitochondria hypothesis of those devastating diseases advocates reasonably in favor of the important role that mitochondrial dysfunction may play in the early stages of neurodegeneration by inducing energy deficiency and oxidative stress [11].
\nHowever, the majority of the mitochondrial diseases, being maternally inherited, which are designated as mitochondrial encephalomyopathies [12], are closely connected either with the impairment of nucleus-to-mitochondria signaling or with mutations in mtDNA or nuclear genome that affect seriously the mitochondrial respiratory function even from the initial steps of the life [13], inducing defective oxidative phosphorylation (OXPHOS).
\nIt is well known that mitochondria, as very specific organelles, include several copies (2–10 copies) of their own DNA (mtDNA), which consists of a 16.5 kb circular DNA molecule, being particularly prone to mutation [14]. mtDNA encodes for 37 genes, 13 of them encoding 13 polypeptides, which all are major components of OXPHOS complexes I, III, IV, and V, along with 22 tRNAs and 2 rRNAs, which play an essential role for the expression of the 13 subunits [15].
\nMutations in mtDNA may be related to 25% of childhood-onset diseases [16] and to 75% of adult-onset ones [17], depending on the existing homoplasmy or heteroplasmy. In addition, the accumulation of mtDNA mutations can also induce or facilitate the aging process [18], since a common phenomenon in mammalian aging is the substantial decrease of electron transfer in mitochondria [19, 20].
\nThe mitochondria in addition to energy production compose also reactive oxygen species (ROS), which control redox status and intracellular Ca2+ levels and may induce apoptosis, by activating the mitochondrial permeability transition pore (mtPTP) [21]. In addition, mitochondria play a very important role in neuronal and glial calcium homeostasis due to their high capacity to accumulating Ca2+ [22].
\nResting neurons contain usually minimal Ca2+ that can be increased by the activation of NMDA glutamate receptors, which induce a massive entry of Ca2+ into neurons, resulting in its high accumulation in the mitochondria [23]. Continuous activation of NMDA receptors would therefore induce Ca2+ overload of the mitochondria with the tragic consequence of the cell apoptosis, which frequently occurs as an epilogue of the excitotoxicity [24].
\nThe apoptosis consists of a wide spectrum of biological phenomena [25] including the release of caspase activators [26], the alterations of the electron transport system, the change of mitochondrial transmembrane potential, the disruption of the cellular oxidation-reduction equilibrium, and the activation of the pro-apoptotic Bcl-2 family proteins [27, 28].
\nIn the majority of the mitochondria-related neurological disorders, the functional or morphological alteration of the mitochondrial may be induced by increased ROS production, abnormal protein aggregates (Ab, tau) [29, 30], mutations in genes encoded by the mitochondrial and nuclear genome, and exposure of the cell to toxic factors [31].
\nCell mitochondria could be visualized in light microscopy in properly fixed material by means of a number of special staining reactions [32, 33, 34]. It is observed that their size generally ranges from 0.5 to 1 micron in diameter, being changeable due to frequent divisions and fusions, which are controlled by mitofusin activity [35]. The shape of the mitochondria is also continuously changed due to their impressive active motility, controlled by calcium signal [36, 37], given that they are in constant flux, especially in brain’s areas of high energy consumption in order to contribute in energy supply and to participate in the intracellular signaling actively [38].
\nElectron microscopy has been contributing greatly in the study of mitochondria in health and disease [39, 40]. Each mitochondrion in healthy condition is surrounded by a limiting double membrane and includes numerous longitudinal or tubular invaginations called mitochondrial cristae that are folds of the inner layer of the double membrane [41], which is four times greater than the outer one.
\nThe cristae are mostly arranged perpendicularly to the long axis of the organelle, exhibiting a high morphological variability according to metabolic demands of the cell [42], being frequently lamellar, tubular, or triangle-shaped. In the majority of the mitochondria, the cristae are arranged parallel to one another inside a structure-less matrix, which is clearly seen among the cristae.
\nCardiolipin seems to play a crucial role in the morphology of cristae, since the disruption of cardiolipin biosynthesis induces obvious alteration of the cristae morphology [43]. In addition, Opa1, which is a GTPase, demonstrating dynamin-like properties, plays a substantial role in the modulation of the cristae structure and in their remodeling during mitochondrial fusion and fission [44] and apoptotic process [45]. The cristae have a high protein content [46], being also the principal site of the oxidative phosphorylation [47].
\nElectron microscope tomography, revealing the three-dimensional appearance of the cristae, shows that they are connected with the inner mitochondrial membrane by a narrow, tubular opening, characterized as “crista junction” (CJ), which is associated with protein import [48] and mitochondrial inner compartmentalization [49].
\nIn neurodegeneration such as in Alzheimer’s disease, mitochondrial cristae are disrupted even from the initial stages of the disease, and concentric patterns of cristae membranes are frequently seen [50].
\nMitochondria, like many other cell organelles, are oriented and positioned properly in neurons and glia in order to be able to fulfill the energy demands of the cells perpetually. Thus, neurons, axons, dendrites, and synapses, which are characterized by high ceaseless activity, have intensive mitochondrial motility and impressive concentrations [51], via various trafficking patterns [52].
\nAxonal transport of mitochondria [53] requires microtubules (MTs) [54, 55] or actin filaments in axons [56], which facilitate the movement of the mitochondria in areas of high metabolic demands and increased energy consumption [57]. It is noticed that disruption of axonal transport of mitochondria occurs as an early phenomenon in cases of neuroinflammation [58], including multiple sclerosis [59, 60, 61].
\nA considerable number of syndromes have been described with marked neurological phenomena in the spectrum of mitochondrial disorders [62]. The severity of the clinical manifestation of mitochondrial dysfunction varies considerably, given that there exists a threshold in the degree of mitochondrial deficiency for the clinical expression of the disease [63, 64]. Thus, the symptoms and clinical phenomena are continuously aggravated, in the majority of the cases of mitochondrial diseases, as the age of the patients advances [65]. It is reasonable to accept that organs with high energy demand would be more seriously affected by the mitochondrial dysfunction than others with low level of energy necessity. Thus the brain, the skeletal muscles, and the heart have a typical involvement in adolescence and adulthood, though multi-system manifestation is not also an uncommon phenomenon, especially in childhood.
\nMany clinical syndromes have been described that are associated with mitochondrial dysfunction including encephalomyopathy, stroke-like episodes, myoclonic epilepsy, neuro-gastrointestinal phenomena, cranial or peripheral neuropathy, ataxia, retinitis pigmentosa, chronic progressive external ophthalmoplegia which are associated frequently with lactic acidosis, mental retardation, or progressive mental decline [66].
\nIn addition, oxidative stress, due to mitochondrial dysfunction, plays a principal role, as causative factor, in the neurodegeneration [67] and in Alzheimer’s disease particularly [68, 69], and it is considered as been among the potential risk factors for the neurometabolic and neoplastic diseases, as well as obesity [70].
\nMolecular genetic testing on one hand and muscle biopsy on the other hand for the histochemical investigation in light microscopy and the ultrastructural study in electron microscopy of the muscle tissue are essential diagnostic procedures for approaching the diagnosis of mitochondrial disorders [71]. In addition, biochemical testing in blood, urine, and spinal fluid associated with neuroimaging [72] would be useful diagnostic procedures in following in time the progression of mitochondrial diseases [71].
\nA final escape from the labyrinth of mitochondrial-related neurological disorders is extremely difficult and less pragmatic under the present circumstances. Prospectively, an efficient treatment could be based on a stable modulation of mtDNA heteroplasmy [73], whereas gene therapy, gene transfer, and tRNA-targeted therapeutic attempts [74] as well as stem cell therapy for nuclear DNA mutations [75, 76] are very promising therapeutic endeavors with substantial medical and scientific value [77, 78].
\nIn addition, an efficient and easy to apply treatment of mitochondrial dysfunction would open new bright horizons in the therapy of the inflammatory and neurodegenerative disorders [79], being beneficial in the amelioration of the quality of life of a substantial number of seriously suffering human beings.
\nPrebiotics and probiotics have been proven to confer multiple health benefits to animals and humans alike when consumed either singly or in combination. Consumption of prebiotics and probiotics modulates the gut microbiota and the colonization of the gastrointestinal tract which is now known as the second gene pool of the human body. Evidence shows the health benefits of synbiotic intake in many aspects of human health including metabolic functions, gastrointestinal diseases, and bone health. Some of these documented evidence-based benefits include their immunomodulatory effect [1], improvement of diarrhea, lactose metabolism, digestive health and metabolic syndrome [2], antidiabetic and hypocholestrolemic [3], anticarcinogenic [4] and hypotensive attributes/features [5]. In a short review that we conducted, the importance of prebiotics, probiotics and synbiotics was expressed to be important across human lifespan from childhood to adulthood and the elderly [6].
\nProbiotics in the presence of prebiotics undergo different biochemical pathways/messenger systems to inhibit pathogens and boost the immunity of the host, these includes
Presence of probiotics in the gut leads to competition for nutrients with pathogens which can then lead to starvation and reduction of these unwanted bacteria.
Probiotics tend to compete for space via the adhesion effect to the mucosal lining by directly decreasing the adhesion of the pathogens and their toxins; this has been confirmed by in vitro studies demonstrating that probiotics possess lectin-like adhesion properties capable of binding carbohydrates from the receptors of glycoconjugate of epithelial cell surface [7] which blocks pathogen binding to the epithelial cell surface. Some probiotic strains of the
Probiotics are responsible for the synthesis of bacteriocins such as lantibiotics (class I) and class II bacteriocins by the probiotics, and this mainly by lactic acid bacteria (LAB) can help prevent the growth, colonization, and establishment of pathogens in the gut environments. These bacteriocins present a better activity on the pathogens than antibiotics due to their narrow-spectrum activity on foreign unwanted bacteria. Bacteriocins from Gram-positive bacteria are composed of membrane peptides capable of targeting and causing apoptosis of the cell membrane; however, most antibiotics inhibit enzymes and biosynthesis pathway in cells such as DNA, RNA, protein and cell-wall synthesis [9].
Probiotic microorganisms may also be able to produce enzymes, such as lipase, esterase, and co-enzymes A, Q, NAD, and NADP [10]. Likewise, some of the by-products of probiotics’ metabolism may exhibit antibiotic properties and these include bacitracin, lactacin and acidophiline [11].
The bio-metabolization of prebiotics into lactate and short chain fatty acids (SCFAs) such as acetate, mainly produced by
The production of butyrate is mainly from complex carbohydrates through the pyruvate and acetyl-coenzyme A (CoA) pathway; however, it can also be produced from amino acids via the glutarate, 4-aminobutyrate and lysine pathways in the gut [13]. Butyrate acts epigenetically as histone deacetylase (HDAC) inhibitors and the research into HDAC may be capable of providing cancer chemoprevention and therapies [16]. There are different functions of butyrate in the colon; it is the main source of energy for colonocytes. Furthermore, butyrate has been documented to inhibit proinflammatory cytokines such as tumor necrosis α (TNF-α) in monocytes [17], interferon-α (IFN-α) and IL-2 in rat mesenteric lymph nodes [18], chemokine CXCL-8 (IL-8) in Caco-2 cells [19].
Intake of prebiotics and probiotics has been linked to the development of immunomodulatory capacity by decreasing inflammation, antibody response and phagocytosis. Probiotics may be involved in the prevention of cytokine-induced epithelial damage.
Probiotic and prebiotic intake results in the improvement of the epithelial barrier integrity by the secretion of mucin [21] and defensins [22] including antimicrobial proteins (AMPs). Probiotics enhance the mucosal integrity also by inducing cytoprotective substance production by enterocytes such as heat shock proteins [23]. In an in vitro study,
Prebiotics and probiotics are capable of the stimulation and production of antioxidant-related enzymes, systemic hormones, and neurochemicals such as serotonin, gamma-aminobutyric acid (GABA) and cortisol, as well as production of bile salt hydrolase. Consumption of probiotics and prebiotics has also been reported to be able to reduce cholesterol levels. Prebiotic fibers increased levels of satiety hormones (glucagon-like peptide-1, proglucagon and peptide YY mRNA) and decreased levels of ghrelin O-acyltransferase mRNA in rats [26]. Furthermore, prebiotic fermentation in the gut likewise improved satietogenic and incretin gut peptide production, thereby increasing the plasma glucagon-like peptide 1 and peptide YY concentrations in humans [27].
Prebiotics and probiotics are responsible for the synthesis of antigens via production of anti-inflammatory cytokine such as IL-10 which inhibits the T-helper cells (1, 2, 7 and 17) and transforming growth factor-β responsible for the production of immunoglobulin A [28].
The concept and use of prebiotics has been argued to be more important when compared to probiotics due to the vulnerability and susceptibility of probiotics to environmental stresses, manufacturing process (such as heat) and endangered conditions during storage [29].
\nGlenn Gibson and Marcel Roberfroid launched the prebiotic concept in 1995 as ‘a nondigestible food ingredient that beneficially affects the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon, and thus improves host health’ [30]. This definition has however been modified several times, but the initial main features have been retained. Prebiotics tend to stimulate the growth of the gut bacteria endogenously. The pH of the gut environment plays a major role in determining bacterial interspecies competition outcome.
\nFood sources of prebiotics consist of edible plants such as fruits, vegetables, cereal component which provides the body with carbohydrate. Specific potential sources are artichokes, tomatoes, bananas, asparagus, garlic, berries, kiwi fruit, onions, chicory, green leafy vegetables, legumes as well as linseed, barley, oats, and wheat.
\nEven though various molecules can be prebiotics, the great majority are dietary fibers which are oligosaccharides such as inulin (mainly from chicory), GOS (obtained from lactose using β-galactosidase), Fructooligosaccharides (FOS) (from chicory by partial enzymatic hydrolysis), soybean oligosaccharides (SOS), and xylooligosaccharides (XOS). Inulin, GOS and FOS have been widely studied. The list of prebiotics also includes compounds such as resistant starches, arabinoxylan, pectin, whole grains as well as non-carbohydrate complex such as polyphenols [13]. Absence of dietary fiber in the colon causes anaerobic bacteria to obtain their energy from protein fermentation, and this metabolism leads to the production of potentially toxic and carcinogenic compounds such as ammoniac and phenolic compounds [31]. In contrast, carbohydrate fermentation (for example dietary fiber) will produce non-toxic SCFAs which can serve as fuel for the epithelial cells. The production of volatile fatty acids, including, SCFAs and BCFAs, play a role in energy homeostasis maintenance as well as in the regulation of functionality in peripheral tissues [32]. Prebiotics are also mainly active in the large intestine/colon.
\nDifferent strains of bacterial genus or species would prefer different substrates for fermentation in the colon. Generally, the strains of
The use of prebiotics has been shown to be efficient and effective against a few human health disorders such as Type 2 diabetes mellitus and inflammatory bowel diseases which has been termed the “Western” chronic diseases and colorectal cancer. This is accomplished by the modulation of the intestinal gut microbiota which confer a protective, metabolic, and trophic benefits to the host [13].
\nThe history of probiotics spans back to the 20th century when Mechnicoff (1907) revealed the virtues associated with the consumption of fermented dairy products, he hypothesized that the aging process resulted from the putrefaction of the large intestine. Almost simultaneously, another scientist Tissier indicated that the main component of the gut flora of breast-fed infants were bifidobacterial [35]. Even earlier, biblical recommendations have pointed out yoghurt as important/significant for the treatment of some ailments [36]. Furthermore, the indication has been that probiotics is more beneficial when consumed with food as opposed to supplement due to the available nutrient and energy sources. Probiotics are mainly active in the small and large intestine.
\nOrganizations such as FAO, WHO and the European Food Safety Authority have indicated probiotic strains must meet both safety and effectiveness criteria for their selection process. The regulations require that safety and absence of risks is paramount for human and animal health. The human probiotic products usually belong to the
Probiotic use has been postulated to be potent against human disorders such as inflammatory enteral diseases such as Crohn’s disease, colitis, and non-specific ileitis. Intake of probiotics has also been assessed by various studies as capable of treating lactose intolerance, irritable bowel syndrome [37] and in the prevention of peptic ulcers and colorectal cancer [38]. Beneficial effects of probiotics have been observed in the process of digestion, food allergies treatment [39], dental caries [40], and candidoses [41]. The beneficial effects of probiotics observed by the host through augmentation of the epithelial wall, intestinal mucosal and competitive elimination of pathogens has been reported to aid inflammatory bowel disease (determined by cytokine-induced harm to the epithelial cell walls). Probiotics is capable of repressing gut inflammation via the downregulation of Toll-like Receptors’ expression, the prevention of TNF-α entrance into the mononuclear cell in blood and the suppression of enterocyte’s NF-kB (Nuclear Factor kappa-light-chain-enhancer of activated B cells) signaling pathway [42].
\nSynbiotics are a combination of prebiotics and probiotics. The consumption and intake of the combination of prebiotics and probiotics has been reported to stimulate, modulate, and alter the gut microbiota by lowering the colonic secretion of pro-inflammatory and immunoregulatory cytokines such as TNF-α, IL-1β and IL-6. Synbiotics can be used to help improve the beneficial microbes as well as increase the number of specific beneficial strains in the gastrointestinal tract [11].
\nImmunomodulatory effects of prebiotics and probiotics on human health.
\nOne the putative ways by which prebiotics and probiotics affect the health is altering the immune system. There are two categories of the immune system: either the innate immunity or the adaptive immune system. The immune system is responsible for protecting the host against pathogens. The type of effective immune response which recognizes and mounts reactions to eliminate the pathogen is determined by the site and type of pathogen present. Prebiotics and probiotics modulate the gut immune system thereby also having effects on bone health.
\nFurther studies are needed to investigate the benefits of synbiotics on bone health both in human and animal model.
\nBone loss/osteoporosis is a major health problem that is associated with the imbalance between bone formation and bone resorption; often resulting in osteoporotic fractures. In addition, the estimation is that one in two women and one in four men over the age of 50 years will break a bone due to osteoporosis in their life time [43]. Postmenopausal osteoporosis is largely attributed to estrogen deficiency in women age 50 years and above due to ablation of the ovarian function which stimulates bone resorption resulting in bone loss. Risk factors leading to bone diseases include internal (genetic and aging) and external modifiable factors (e.g., diet, exercise, environment, medication etc). In osteoporosis treatment, different approaches have been used but lately due to the safety, low adverse effect and lack of major side effects, probiotics and prebiotics have been introduced. Treatment of bone diseases including osteoporosis and fracture has been mainly through hormone replacement therapy (HRT) as well as others such as bisphosphonates and more recently low-dose parathyroid hormone. However, there are side effects reported with this such as tumorigenesis, mood swings, fluid retention and bleeding as well as low compliance of daily injections [44].
\nProbiotics may aid the modulation of the hosts’ inflammatory status by reducing the cytokine secretion levels. The downregulation of proinflammatory cytokines such as IL-6 [45] and TNF-α [46, 47] by probiotics has been reported on several occasions. Studies have shown that some peptides such as p40 and p75 secreted by
The role of the intestinal microbiota has been implicated in influencing bone health. A way by which the intestinal tract aids bone is by the regulation of the absorption of minerals such as calcium, phosphorus, and magnesium. This can also be accomplished by endocrine and gut-derived factors such as incretins and serotonins which may influence bone remodeling. Evidence from using germ-free mice indicated the effect of the intestinal microbiome on bone physiology. These studies observed higher bone mass in germ-free mice as compared to the conventional mice. In addition, a decrease in the number of osteoclasts per bone surface and a reduction in CD4+ T cells and osteoclasts precursors were observed in the bone marrow of the mice [50].
\nThe RANKL/RANK/OPG pathway is one of the mechanisms that influence bone turnover/remodeling. Osteoclast’s formation and activities are controlled by the RANKL/RANK pathway. They are also an essential pathological process of the bone remodeling. Concomitantly, OPG (decoy receptor of RANKL) acts as a bone protector by binding to RANKL and preventing further resorption [42]. Probiotics (beneficial microbes) have been postulated to reduce inflammation [51] and increase OPG expression in bone [52].
\nStudies have shown that various strains of
\n
Probiotics are known to aid mineral absorption for the purpose of bone health maintenance. A study showed that supplementation of growing rats with
Narva et al. demonstrated the effect a bioactive peptide (valylprolyl-proline) and
Studies have also shown that supplementation with
In a study, male senescence-accelerated mice prone to developing osteoporosis with aging were orally administered heat-killed and living (viable)
The growth of bone as an extra-intestinal organ is suppressed by undernutrition in children. The study by Schwarzer et al. indicated that
Furthermore, the effects of probiotics have also been reported in dysbiosis-induced bone loss observed in the periodontal model [67, 68], Type-1 diabetes-induced bone loss [69] and IBD-induced bone loss [70, 71].
\nA human study conducted in Denmark evaluated the combined effects of bioavailable isoflavones and probiotics on bone health and estrogen metabolism using a randomized controlled trial in postmenopausal women. Their findings showed that administration red clover extract (isoflavones) and probiotic attenuated BMD at the lumbar spine and femoral neck, reduced plasma concentrations of C-terminal telopeptide of type I collagen (CTX-1) as well as increased the urinary 2-hydroxyestrone (2-OH) to 16α-hydroxyestrone (16α-OH) ratio (the equol producer status) [72].
\nThe use of probiotics however needs to be administered with caution since although the potential beneficial effect in the treatment of inflammatory and auto-immune gastrointestinal diseases for the modulation of immune response is well recognized, individuals with weaker immune systems may still be at risk of viable bacterial cells; in which case the administration the use of killed/inactivated bacteria might be more beneficial [73].
\nPrebiotics are non-digestible short-chain carbohydrates also known as oligosaccharides (and maybe polysaccharides) which selectively improves the function and activities of specific types of beneficial microbes. The chemical compounds are neither hydrolyzed by the human digestive system nor absorbed in the upper gastrointestinal tract. Prebiotics have been termed ‘colonic foods’ due to the ability of these types of foods to move through the colon serving as a substrate to endogenous bacteria while benefitting the host by providing energy and essential nutrients [74].
\nSome varieties of benefits have been attributed to the consumption of prebiotics. These include the ability of prebiotics to increase the absorption of minerals such as calcium, magnesium, and phosphorus [75, 76, 77, 78] as well as iron [79] as reported quite recently. The absorption of these minerals has consequently been observed to improve bone mineralization and density [80], trabecular structure and increase equol production [81] which is known to reduce bone loss.
\nFOS supplementation has been administered to both Korean [82] and Chinese [83] postmenopausal women to investigate its effect in the prevention of osteoporosis, modulation of bone biomarkers and mineral absorption. Their findings indicate that there is potential for prebiotics to play a pivotal role in the above mentioned. The study by van den Heuvel et al. reported the benefit of intake of both GOS and inulin in increasing calcium absorption in postmenopausal women [84] and oligofructose stimulating calcium absorption in adolescents [85]. Intake of oligofructose-enriched inulin resulted in improved mineral absorption and impacted the bone turnover markers in postmenopausal women [86]. Other studies also looked into the effect of prebiotics in infants as was recorded with GOS, polydextrose [87] and inulin [88]. Some of these studies have also been conducted in animal models as has been shown in a recent review [89].
\nDue to the effect of the change in metabolism from protein fermentation causing the release of ammonia that leads to an increase in pH to more carbohydrate fermentation resulting in the release of acids, a reduction in the intestinal pH is observed. Low intestinal pH tends to increase bowel movement while protecting against pathogens. Diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and Crohn’s diseases are characterized by high pH levels [90]. Prebiotics are therefore able to reduce the symptoms and severity of these diseases. In addition, they are able to restore intestinal bacterial imbalance created by antibiotics, diarrhea, stress and sometimes medication and drugs intake [74].
\nPrebiotics are also known to help relief constipation. Most carbohydrates are able to increase water retention of the intestine and the acids’ production thereby increasing intestinal motility [91]. Furthermore, prebiotics have been used as bioactive functional foods to modulate blood lipid levels [92] and it also been effective in weight loss and metabolic syndrome [93]. The anti-carcinogenic effects of both prebiotics and probiotics have been reported in the inhibition of aberrant crypt foci (ACF) which is a biomarker of colon cancer [94, 95, 96].
\nRecently, prebiotic food and Bidobacterium spp. have been reported to improve bone resorption and reduce serum TRACP-5b levels of Japanese female athletes [97]. Application of the combination of probiotic and prebiotic has been reported to confer a synergistical effect on the host due to the combined benefits of the two. This has been backed with the study by Scholz-Ahrens et al. which showed that probiotics supports the growth of other habitual microbiota strains and prebiotics chain length impacts the composition colonic, caecal, and fecal microflora. The combined administration of oligofructose and
The study of the effect of synbiotics on gut microbiota and bone health profile is now growing rapidly. Probiotic strains have differing genotype and phenotype and may therefore show different metabolic and immunological functions. The mechanisms however still need further investigation to look into the effect of synbiotics on the gut for the regulation of bone metabolism via the process of mineral absorption, the immune, endocrine system. Further studies are needed to elucidate the importance and mechanisms by which prebiotics and probiotics modulates the microbiota-gut-bone axis in order to get the full benefit of the long-term safety and efficacy of consumption of these functional bioactive products.
\nWe believe financial barriers should not prevent researchers from publishing their findings. With the need to make scientific research more publicly available and support the benefits of Open Access, more and more institutions and funders are dedicating resources to assist faculty members and researchers cover Open Access Publishing Fees (OAPFs). In addition, IntechOpen provides several further options presented below, all of which are available to researchers, and could secure the financing of your Open Access publication.
",metaTitle:"Waiver Policy",metaDescription:"We feel that financial barriers should never prevent researchers from publishing their research. With the need to make scientific research more publically available and support the benefits of Open Access, more institutions and funders have dedicated funds to assist their faculty members and researchers cover the APCs associated with publishing in Open Access. Below we have outlined several options available to secure financing for your Open Access publication.",metaKeywords:null,canonicalURL:"/page/waiver-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"At IntechOpen, the majority of OAPFs are paid by an Author’s institution or funding agency - Institutions (73%) vs. Authors (23%).
\\n\\nThe first step in obtaining funds for your Open Access publication begins with your institution or library. IntechOpen’s publishing standards align with most institutional funding programs. Our advice is to petition your institution for help in financing your Open Access publication.
\\n\\nHowever, as Open Access becomes a more commonly used publishing option for the dissemination of scientific and scholarly content, in addition to institutions, there are a growing number of funders who allow the use of grants for covering OA publication costs, or have established separate funds for the same purpose.
\\n\\nPlease consult our Open Access Funding page to explore some of these funding opportunities and learn more about how you could finance your IntechOpen publication. Keep in mind that this list is not definitive, and while we are constantly updating and informing our Authors of new funding opportunities, we recommend that you always check with your institution first.
\\n\\nFor Authors who are unable to obtain funding from their institution or research funding bodies and still need help in covering publication costs, IntechOpen offers the possibility of applying for a Waiver.
\\n\\nOur mission is to support Authors in publishing their research and making an impact within the scientific community. Currently, 14% of Authors receive full waivers and 6% receive partial waivers.
\\n\\nWhile providing support and advice to all our international Authors, waiver priority will be given to those Authors who reside in countries that are classified by the World Bank as low-income economies. In this way, we can help ensure that the scientific work being carried out can make an impact within the worldwide scientific community, no matter where an Author might live.
\\n\\nThe application process is open after your submitted manuscript has been accepted for publication. To apply, please fill out a Waiver Request Form and send it to your Author Service Manager. If you have an official letter from your university or institution showing that funds for your OA publication are unavailable, please attach that as well. The Waiver Request will normally be addressed within one week from the application date. All chapters that receive waivers or partial waivers will be designated as such online.
\\n\\nDownload Waiver Request Form
\\n\\nFeel free to contact us at funders@intechopen.com if you have any questions about Funding options or our Waiver program. If you have already begun the process and require further assistance, please contact your Author Service Manager, who is there to assist you!
\\n\\nNote: All data represented above was collected by IntechOpen from 2013 to 2017.
\\n"}]'},components:[{type:"htmlEditorComponent",content:'At IntechOpen, the majority of OAPFs are paid by an Author’s institution or funding agency - Institutions (73%) vs. Authors (23%).
\n\nThe first step in obtaining funds for your Open Access publication begins with your institution or library. IntechOpen’s publishing standards align with most institutional funding programs. Our advice is to petition your institution for help in financing your Open Access publication.
\n\nHowever, as Open Access becomes a more commonly used publishing option for the dissemination of scientific and scholarly content, in addition to institutions, there are a growing number of funders who allow the use of grants for covering OA publication costs, or have established separate funds for the same purpose.
\n\nPlease consult our Open Access Funding page to explore some of these funding opportunities and learn more about how you could finance your IntechOpen publication. Keep in mind that this list is not definitive, and while we are constantly updating and informing our Authors of new funding opportunities, we recommend that you always check with your institution first.
\n\nFor Authors who are unable to obtain funding from their institution or research funding bodies and still need help in covering publication costs, IntechOpen offers the possibility of applying for a Waiver.
\n\nOur mission is to support Authors in publishing their research and making an impact within the scientific community. Currently, 14% of Authors receive full waivers and 6% receive partial waivers.
\n\nWhile providing support and advice to all our international Authors, waiver priority will be given to those Authors who reside in countries that are classified by the World Bank as low-income economies. In this way, we can help ensure that the scientific work being carried out can make an impact within the worldwide scientific community, no matter where an Author might live.
\n\nThe application process is open after your submitted manuscript has been accepted for publication. To apply, please fill out a Waiver Request Form and send it to your Author Service Manager. If you have an official letter from your university or institution showing that funds for your OA publication are unavailable, please attach that as well. The Waiver Request will normally be addressed within one week from the application date. All chapters that receive waivers or partial waivers will be designated as such online.
\n\nDownload Waiver Request Form
\n\nFeel free to contact us at funders@intechopen.com if you have any questions about Funding options or our Waiver program. If you have already begun the process and require further assistance, please contact your Author Service Manager, who is there to assist you!
\n\nNote: All data represented above was collected by IntechOpen from 2013 to 2017.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[],filtersByRegion:[],offset:0,limit:12,total:null},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"1",sort:"dateEndThirdStepPublish",topicId:"9,11,22,10"},books:[{type:"book",id:"11554",title:"Information Systems Management",subtitle:null,isOpenForSubmission:!0,hash:"3134452ff2fdec020663f241c7a9a748",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11554.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11546",title:"Smart and Sustainable Transportation",subtitle:null,isOpenForSubmission:!0,hash:"e8ea27a1ff85cde00efcb6f6968c20f8",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11546.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11834",title:"Steppe Geography",subtitle:null,isOpenForSubmission:!0,hash:"363517fa6f079daf94c51ea1b91fed2a",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11834.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11836",title:"Estuary Research",subtitle:null,isOpenForSubmission:!0,hash:"ef822fc9eee5600aeb7e45492e04a6e7",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11836.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11837",title:"The Mediterranean",subtitle:null,isOpenForSubmission:!0,hash:"bbb25987a982d61da4f47fb13614ba3c",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11837.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11846",title:"Seabed",subtitle:null,isOpenForSubmission:!0,hash:"1b1698a2d8d36b5ec3571c20486eb2c9",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11846.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11942",title:"Updates on Spatial Audio",subtitle:null,isOpenForSubmission:!0,hash:"f4ac095defb765e0e9bfebc06dac719e",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11942.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11911",title:"Scientometrics",subtitle:null,isOpenForSubmission:!0,hash:"ed74b66a0dc7d009900af198efc6b2e1",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11911.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11913",title:"Scheduling Algorithms",subtitle:null,isOpenForSubmission:!0,hash:"da42ea7b678d715e23ffcae50ae47078",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11913.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11915",title:"Ontology in Computer Science",subtitle:null,isOpenForSubmission:!0,hash:"b52397215f6b5e05a22368f629695704",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11915.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11917",title:"Computational Semantics",subtitle:null,isOpenForSubmission:!0,hash:"bd9343348f2c50dbbc819a0b48a76591",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11917.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11938",title:"Ballistics",subtitle:null,isOpenForSubmission:!0,hash:"9c64ef67aac55216f08c65a2a179835c",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11938.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:42},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:12},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:17},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:18},{group:"topic",caption:"Engineering",value:11,count:46},{group:"topic",caption:"Environmental Sciences",value:12,count:7},{group:"topic",caption:"Immunology and Microbiology",value:13,count:11},{group:"topic",caption:"Materials Science",value:14,count:14},{group:"topic",caption:"Mathematics",value:15,count:6},{group:"topic",caption:"Medicine",value:16,count:107},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:7},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:11},{group:"topic",caption:"Physics",value:20,count:4},{group:"topic",caption:"Psychology",value:21,count:8},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:32},{group:"topic",caption:"Technology",value:24,count:1},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:84},popularBooks:{featuredBooks:[],offset:0,limit:12,total:null},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",publishedDate:"April 28th 2022",numberOfDownloads:3665,editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10222",title:"Demyelination Disorders",subtitle:null,isOpenForSubmission:!1,hash:"b6c26ceccacdde70c41c587361bd5558",slug:"demyelination-disorders",bookSignature:"Stavros J. Baloyannis, Fabian H. Rossi and Welwin Liu",coverURL:"https://cdn.intechopen.com/books/images_new/10222.jpg",publishedDate:"May 4th 2022",numberOfDownloads:1713,editors:[{id:"156098",title:"Emeritus Prof.",name:"Stavros J.",middleName:"J.",surname:"Baloyannis",slug:"stavros-j.-baloyannis",fullName:"Stavros J. Baloyannis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",publishedDate:"April 28th 2022",numberOfDownloads:2481,editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10979",title:"Parenting",subtitle:"Challenges of Child Rearing in a Changing Society",isOpenForSubmission:!1,hash:"6f345ebcf4fd61e73643c69063a12c7b",slug:"parenting-challenges-of-child-rearing-in-a-changing-society",bookSignature:"Sayyed Ali Samadi",coverURL:"https://cdn.intechopen.com/books/images_new/10979.jpg",publishedDate:"May 4th 2022",numberOfDownloads:1107,editors:[{id:"52145",title:"Dr.",name:"Sayyed Ali",middleName:null,surname:"Samadi",slug:"sayyed-ali-samadi",fullName:"Sayyed Ali Samadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3307,editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3266,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10764",title:"Antenna Systems",subtitle:null,isOpenForSubmission:!1,hash:"2fbf1c7a5d92723f08198fc9b526a8ad",slug:"antenna-systems",bookSignature:"Hussain Al-Rizzo and Said Abushamleh",coverURL:"https://cdn.intechopen.com/books/images_new/10764.jpg",publishedDate:"April 28th 2022",numberOfDownloads:1868,editors:[{id:"153384",title:"Prof.",name:"Hussain",middleName:null,surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,isOpenForSubmission:!1,hash:"55856c6a8bc3a5b21dae5a1af09a56b6",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",publishedDate:"May 4th 2022",numberOfDownloads:856,editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,isOpenForSubmission:!1,hash:"176adcf090fdd1f93cb8ce3146e79ca1",slug:"reactive-oxygen-species",bookSignature:"Rizwan Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",publishedDate:"April 28th 2022",numberOfDownloads:1704,editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",publishedDate:"March 16th 2022",numberOfDownloads:7489,editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"204",title:"Urology",slug:"urology",parent:{id:"16",title:"Medicine",slug:"medicine"},numberOfBooks:49,numberOfSeries:0,numberOfAuthorsAndEditors:1410,numberOfWosCitations:486,numberOfCrossrefCitations:335,numberOfDimensionsCitations:780,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"204",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10355",title:"Urinary Tract Infection and Nephropathy",subtitle:"Insights into Potential Relationship",isOpenForSubmission:!1,hash:"ca250be6457e17cd92a4e48ffc32724d",slug:"urinary-tract-infection-and-nephropathy-insights-into-potential-relationship",bookSignature:"Ran Pang",coverURL:"https://cdn.intechopen.com/books/images_new/10355.jpg",editedByType:"Edited by",editors:[{id:"186524",title:"Prof.",name:"Ran",middleName:null,surname:"Pang",slug:"ran-pang",fullName:"Ran Pang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10724",title:"Male Reproductive Anatomy",subtitle:null,isOpenForSubmission:!1,hash:"a3fdda3194735da4287e9ea193beb07e",slug:"male-reproductive-anatomy",bookSignature:"Wei Wu",coverURL:"https://cdn.intechopen.com/books/images_new/10724.jpg",editedByType:"Edited by",editors:[{id:"178661",title:"Dr.",name:"Wei",middleName:null,surname:"Wu",slug:"wei-wu",fullName:"Wei Wu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10339",title:"Modern Approach to Diagnosis and Treatment of Bladder Cancer",subtitle:null,isOpenForSubmission:!1,hash:"d1fdae263fb8a59eef2795dc748a1155",slug:"modern-approach-to-diagnosis-and-treatment-of-bladder-cancer",bookSignature:"Francesco Ziglioli and Umberto Maestroni",coverURL:"https://cdn.intechopen.com/books/images_new/10339.jpg",editedByType:"Edited by",editors:[{id:"62240",title:"Dr.",name:"Francesco",middleName:null,surname:"Ziglioli",slug:"francesco-ziglioli",fullName:"Francesco Ziglioli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6424",title:"Evolving Trends in Kidney Cancer",subtitle:null,isOpenForSubmission:!1,hash:"e9305ef1c5e6ad63407fd9262a27cf31",slug:"evolving-trends-in-kidney-cancer",bookSignature:"Sashi S. Kommu and Inderbir S. Gill",coverURL:"https://cdn.intechopen.com/books/images_new/6424.jpg",editedByType:"Edited by",editors:[{id:"9902",title:"Dr.",name:"Sashi S.",middleName:"S",surname:"Kommu",slug:"sashi-s.-kommu",fullName:"Sashi S. Kommu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7985",title:"Circumcision and the Community",subtitle:null,isOpenForSubmission:!1,hash:"023cc135aeeae6d2ea8cfc01ab3f4dc7",slug:"circumcision-and-the-community",bookSignature:"Ahmad Zaghal and Nishat Rahman",coverURL:"https://cdn.intechopen.com/books/images_new/7985.jpg",editedByType:"Edited by",editors:[{id:"240621",title:"Dr.",name:"Ahmad",middleName:null,surname:"Zaghal",slug:"ahmad-zaghal",fullName:"Ahmad Zaghal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7957",title:"Lower Urinary Tract Dysfunction",subtitle:"From Evidence to Clinical Practice",isOpenForSubmission:!1,hash:"e29f9949691e86e226d6c7f7aa81134c",slug:"lower-urinary-tract-dysfunction-from-evidence-to-clinical-practice",bookSignature:"Ran Pang",coverURL:"https://cdn.intechopen.com/books/images_new/7957.jpg",editedByType:"Edited by",editors:[{id:"186524",title:"Prof.",name:"Ran",middleName:null,surname:"Pang",slug:"ran-pang",fullName:"Ran Pang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7931",title:"Male Reproductive Health",subtitle:null,isOpenForSubmission:!1,hash:"5754baea5de6a634c66bae12a33d52d9",slug:"male-reproductive-health",bookSignature:"Wei Wu, Francesco Ziglioli and Umberto Maestroni",coverURL:"https://cdn.intechopen.com/books/images_new/7931.jpg",editedByType:"Edited by",editors:[{id:"178661",title:"Dr.",name:"Wei",middleName:null,surname:"Wu",slug:"wei-wu",fullName:"Wei Wu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7935",title:"Renal Diseases",subtitle:null,isOpenForSubmission:!1,hash:"44715ed141cf23ebdd35ff0d772492df",slug:"renal-diseases",bookSignature:"Edward T. Zawada Jr. and Sohail Abdul Salim",coverURL:"https://cdn.intechopen.com/books/images_new/7935.jpg",editedByType:"Edited by",editors:[{id:"16344",title:"Dr.",name:"Edward T.",middleName:null,surname:"Zawada Jr.",slug:"edward-t.-zawada-jr.",fullName:"Edward T. Zawada Jr."}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8459",title:"Glomerulonephritis and Nephrotic Syndrome",subtitle:null,isOpenForSubmission:!1,hash:"404561518d53b3dd68ce74d6225588c0",slug:"glomerulonephritis-and-nephrotic-syndrome",bookSignature:"Thomas Rath",coverURL:"https://cdn.intechopen.com/books/images_new/8459.jpg",editedByType:"Edited by",editors:[{id:"67436",title:"Dr.",name:"Thomas",middleName:null,surname:"Rath",slug:"thomas-rath",fullName:"Thomas Rath"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7511",title:"Aspects in Continuous Renal Replacement Therapy",subtitle:null,isOpenForSubmission:!1,hash:"b844bd530165ca058e32517002b29837",slug:"aspects-in-continuous-renal-replacement-therapy",bookSignature:"Ayman Karkar",coverURL:"https://cdn.intechopen.com/books/images_new/7511.jpg",editedByType:"Edited by",editors:[{id:"156627",title:"Dr.",name:"Ayman",middleName:null,surname:"Karkar",slug:"ayman-karkar",fullName:"Ayman Karkar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7276",title:"Advances in Nephropathy",subtitle:null,isOpenForSubmission:!1,hash:"487b332191e4266ae8e9d24b9b0a0985",slug:"advances-in-nephropathy",bookSignature:"Thomas Rath",coverURL:"https://cdn.intechopen.com/books/images_new/7276.jpg",editedByType:"Edited by",editors:[{id:"67436",title:"Dr.",name:"Thomas",middleName:null,surname:"Rath",slug:"thomas-rath",fullName:"Thomas Rath"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6423",title:"Prostate Cancer",subtitle:null,isOpenForSubmission:!1,hash:"d072a079624084c12169a118fdbbfa87",slug:"prostate-cancer",bookSignature:"Cem Onal",coverURL:"https://cdn.intechopen.com/books/images_new/6423.jpg",editedByType:"Edited by",editors:[{id:"43940",title:"Dr.",name:"Cem",middleName:null,surname:"Onal",slug:"cem-onal",fullName:"Cem Onal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:49,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"37101",doi:"10.5772/36832",title:"The Psychological Impact of Hemodialysis on Patients with Chronic Renal Failure",slug:"the-psychological-impact-of-hemodialysis-on-patients-with-chronic-renal-failure",totalDownloads:6093,totalCrossrefCites:10,totalDimensionsCites:23,abstract:null,book:{id:"1746",slug:"renal-failure-the-facts",title:"Renal Failure",fullTitle:"Renal Failure - The Facts"},signatures:"Liang-Jen Wang and Chih-Ken Chen",authors:[{id:"110035",title:"Dr.",name:"Liang Jen",middleName:null,surname:"Wang",slug:"liang-jen-wang",fullName:"Liang Jen Wang"}]},{id:"30215",doi:"10.5772/39088",title:"\ufeffMechanisms in Erectile Function and Dysfunction: An Overview",slug:"mechanisms-in-erectile-function-and-dysfunction-an-overview",totalDownloads:7449,totalCrossrefCites:1,totalDimensionsCites:19,abstract:null,book:{id:"686",slug:"erectile-dysfunction-disease-associated-mechanisms-and-novel-insights-into-therapy",title:"Erectile Dysfunction",fullTitle:"Erectile Dysfunction - Disease-Associated Mechanisms and Novel Insights into Therapy"},signatures:"Kenia Pedrosa Nunes and R. Clinton Webb",authors:[{id:"71405",title:"Dr.",name:"Kenia",middleName:"Pedrosa",surname:"Nunes",slug:"kenia-nunes",fullName:"Kenia Nunes"},{id:"134106",title:"Dr.",name:"R. Clinton",middleName:null,surname:"Webb",slug:"r.-clinton-webb",fullName:"R. Clinton Webb"}]},{id:"48020",doi:"10.5772/59430",title:"Dialysis Membranes — Physicochemical Structures and Features",slug:"dialysis-membranes-physicochemical-structures-and-features",totalDownloads:5525,totalCrossrefCites:8,totalDimensionsCites:16,abstract:null,book:{id:"4547",slug:"updates-in-hemodialysis",title:"Updates in Hemodialysis",fullTitle:"Updates in Hemodialysis"},signatures:"Akihiro C. Yamashita and Kenji Sakurai",authors:[{id:"171999",title:"Prof.",name:"Akihiro",middleName:null,surname:"Yamashita",slug:"akihiro-yamashita",fullName:"Akihiro Yamashita"}]},{id:"21272",doi:"10.5772/22857",title:"Polyethersulfone Hollow Fiber Membranes for Hemodialysis",slug:"polyethersulfone-hollow-fiber-membranes-for-hemodialysis",totalDownloads:8994,totalCrossrefCites:6,totalDimensionsCites:15,abstract:null,book:{id:"353",slug:"progress-in-hemodialysis-from-emergent-biotechnology-to-clinical-practice",title:"Progress in Hemodialysis",fullTitle:"Progress in Hemodialysis - From Emergent Biotechnology to Clinical Practice"},signatures:"Baihai Su, Shudong Sun and Changsheng Zhao",authors:[{id:"49545",title:"Prof.",name:"Changsheng",middleName:null,surname:"Zhao",slug:"changsheng-zhao",fullName:"Changsheng Zhao"},{id:"94417",title:"Dr.",name:"Baihai",middleName:null,surname:"Su",slug:"baihai-su",fullName:"Baihai Su"},{id:"94418",title:"Dr.",name:"Shudong",middleName:null,surname:"Sun",slug:"shudong-sun",fullName:"Shudong Sun"}]},{id:"45345",doi:"10.5772/55200",title:"Role of Bacterial Biofilms in Catheter-Associated Urinary Tract Infections (CAUTI) and Strategies for Their Control",slug:"role-of-bacterial-biofilms-in-catheter-associated-urinary-tract-infections-cauti-and-strategies-for-",totalDownloads:3219,totalCrossrefCites:4,totalDimensionsCites:15,abstract:null,book:{id:"3313",slug:"recent-advances-in-the-field-of-urinary-tract-infections",title:"Recent Advances in the Field of Urinary Tract Infections",fullTitle:"Recent Advances in the Field of Urinary Tract Infections"},signatures:"Mary Anne Roshni Amalaradjou and Kumar Venkitanarayanan",authors:[{id:"61657",title:"Prof.",name:"Kumar",middleName:null,surname:"Venkitanarayanan",slug:"kumar-venkitanarayanan",fullName:"Kumar Venkitanarayanan"},{id:"158931",title:"Dr.",name:"Mary Anne Roshni",middleName:null,surname:"Amalaradjou",slug:"mary-anne-roshni-amalaradjou",fullName:"Mary Anne Roshni Amalaradjou"}]}],mostDownloadedChaptersLast30Days:[{id:"71493",title:"Pelvic Organ Prolapse: Examination and Assessment",slug:"pelvic-organ-prolapse-examination-and-assessment",totalDownloads:1073,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Pelvic organ prolapse (POP) is a common, benign condition in women, and patient can present with complaints of vaginal bulge and pressure, voiding and defecatory, and sexual dysfunction, which may adversely affect quality of life. Although POP can occur in younger women, it is commonly seen in aging population with a prevalence of 45–50%. Older terms describing pelvic organ prolapse (e.g., cystocele, urethrocele, rectocele) have been replaced because they do not provide complete information regarding the structures on the other side of the vaginal bulge, especially in women who have had previous pelvic organ prolapse surgery. Therefore, a thorough history and performing a careful physical examination with dignity and care, using some basic tools that aid in the accurate evaluation of anatomical and functional defects, should be conducted. A standardized assessment system has been used to document findings which should explain everything in understandable terms.",book:{id:"7957",slug:"lower-urinary-tract-dysfunction-from-evidence-to-clinical-practice",title:"Lower Urinary Tract Dysfunction",fullTitle:"Lower Urinary Tract Dysfunction - From Evidence to Clinical Practice"},signatures:"Priyanka Bhadana",authors:[{id:"287080",title:"Associate Prof.",name:"Priyanka",middleName:null,surname:"Bhadana",slug:"priyanka-bhadana",fullName:"Priyanka Bhadana"}]},{id:"51296",title:"Peritoneal Dialysis Catheters",slug:"peritoneal-dialysis-catheters",totalDownloads:2338,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In peritoneal dialysis, a well-functioning catheter is of great importance because a dysfunctional catheter may be associated with exit-site infection, peritonitis, reduced efficiency of dialysis, and overall quality of treatment, representing one of the main barriers to optimal use of peritoneal dialysis. This chapter reviews the literature on indications and contraindications for peritoneal dialysis, peritoneal dialysis catheter design and materials, the techniques of insertion, complications, and method of removal of dialysis catheters.",book:{id:"5312",slug:"some-special-problems-in-peritoneal-dialysis",title:"Some Special Problems in Peritoneal Dialysis",fullTitle:"Some Special Problems in Peritoneal Dialysis"},signatures:"O. Obinwa, J. McLoughlin, D. Kavanagh and C. Wall",authors:[{id:"183332",title:"Mr.",name:"Obinna",middleName:null,surname:"Obinwa",slug:"obinna-obinwa",fullName:"Obinna Obinwa"},{id:"188697",title:"Dr.",name:"Joseph",middleName:null,surname:"McLoughlin",slug:"joseph-mcloughlin",fullName:"Joseph McLoughlin"},{id:"188698",title:"Mr.",name:"Dara",middleName:null,surname:"Kavanagh",slug:"dara-kavanagh",fullName:"Dara Kavanagh"},{id:"188699",title:"Dr.",name:"Catherine",middleName:null,surname:"Wall",slug:"catherine-wall",fullName:"Catherine Wall"}]},{id:"47722",title:"Water Treatment for Centre and Home-Based Haemodialysis",slug:"water-treatment-for-centre-and-home-based-haemodialysis",totalDownloads:3507,totalCrossrefCites:3,totalDimensionsCites:4,abstract:null,book:{id:"4547",slug:"updates-in-hemodialysis",title:"Updates in Hemodialysis",fullTitle:"Updates in Hemodialysis"},signatures:"Shyam Dheda, Carolyn Van Eps, Carmel Hawley and David W.\nJohnson",authors:[{id:"50425",title:"Prof.",name:"David",middleName:null,surname:"Johnson",slug:"david-johnson",fullName:"David Johnson"},{id:"172329",title:"Dr.",name:"Carmel",middleName:null,surname:"Hawley",slug:"carmel-hawley",fullName:"Carmel Hawley"},{id:"172514",title:"Dr.",name:"Shyam",middleName:null,surname:"Dheda",slug:"shyam-dheda",fullName:"Shyam Dheda"}]},{id:"53697",title:"Physiotherapy in Women with Urinary Incontinence",slug:"physiotherapy-in-women-with-urinary-incontinence",totalDownloads:2331,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Urinary incontinence is a complex and serious condition that can affect all age groups around the world. It is not only a serious medical condition but also an undeniable psychosocial problem creating embarrassment and negative self‐perception, and it has a severe impact on a patient's quality of life. Today, there are wide different treatment options in urinary incontinence from surgery to conservative modalities. Among these, conservative management approaches are recommended as the first‐line treatment to manage with urinary incontinence. The choice of the most suitable option to treat for urinary incontinence differs according to the underlying pathophysiological mechanism defining subtypes of urinary incontinence and severity of symptoms. In this chapter, we addressed the different components of physiotherapy management of urinary incontinence, including pelvic floor muscle training, electrical stimulation, biofeedback, vaginal cones, mechanical devices and magnetic stimulation. We concluded that the optimal physiotherapy care should be individualised to ensure applicability the clinic setting for each patient.",book:{id:"5352",slug:"synopsis-in-the-management-of-urinary-incontinence",title:"Synopsis in the Management of Urinary Incontinence",fullTitle:"Synopsis in the Management of Urinary Incontinence"},signatures:"Özlem Çinar Özdemir and Mahmut Surmeli",authors:[{id:"185712",title:"Ph.D.",name:"Özlem",middleName:null,surname:"Çinar Özdemir",slug:"ozlem-cinar-ozdemir",fullName:"Özlem Çinar Özdemir"},{id:"193852",title:"Mr.",name:"Mahmut",middleName:null,surname:"Surmeli",slug:"mahmut-surmeli",fullName:"Mahmut Surmeli"}]},{id:"43075",title:"Single-Needle Hemodialysis on Native Fistulae",slug:"single-needle-hemodialysis-on-native-fistulae",totalDownloads:4050,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"3267",slug:"hemodialysis",title:"Hemodialysis",fullTitle:"Hemodialysis"},signatures:"Guy Rostoker",authors:[{id:"155148",title:"Dr.",name:"Guy",middleName:null,surname:"Rostoker",slug:"guy-rostoker",fullName:"Guy Rostoker"}]}],onlineFirstChaptersFilter:{topicId:"204",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"May 13th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",isOpenForSubmission:!0,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},{id:"8",title:"Bioinspired Technology and Biomechanics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",isOpenForSubmission:!0,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",isOpenForSubmission:!0,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. His research interests include biomaterials, nanomaterials, bioengineering, biosensors, drug delivery systems, and tissue engineering.",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:17,paginationItems:[{id:"81751",title:"NanoBioSensors: From Electrochemical Sensors Improvement to Theranostic Applications",doi:"10.5772/intechopen.102552",signatures:"Anielle C.A. Silva, Eliete A. Alvin, Lais S. de Jesus, Caio C.L. de França, Marílya P.G. da Silva, Samaysa L. Lins, Diógenes Meneses, Marcela R. Lemes, Rhanoica O. Guerra, Marcos V. da Silva, Carlo J.F. de Oliveira, Virmondes Rodrigues Junior, Renata M. Etchebehere, Fabiane C. de Abreu, Bruno G. Lucca, Sanívia A.L. Pereira, Rodrigo C. Rosa and Noelio O. Dantas",slug:"nanobiosensors-from-electrochemical-sensors-improvement-to-theranostic-applications",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81766",title:"Evolution of Organoids in Oncology",doi:"10.5772/intechopen.104251",signatures:"Allen Thayakumar Basanthakumar, Janitha Chandrasekhar Darlybai and Jyothsna Ganesh",slug:"evolution-of-organoids-in-oncology",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81678",title:"Developmental Studies on Practical Enzymatic Phosphate Ion Biosensors and Microbial BOD Biosensors, and New Insights into the Future Perspectives of These Biosensor Fields",doi:"10.5772/intechopen.104377",signatures:"Hideaki Nakamura",slug:"developmental-studies-on-practical-enzymatic-phosphate-ion-biosensors-and-microbial-bod-biosensors-a",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hideaki",surname:"Nakamura"}],book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81547",title:"Organoids and Commercialization",doi:"10.5772/intechopen.104706",signatures:"Anubhab Mukherjee, Aprajita Sinha, Maheshree Maibam, Bharti Bisht and Manash K. Paul",slug:"organoids-and-commercialization",totalDownloads:30,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}}]},overviewPagePublishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}]},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",biography:"Michele Lanza is Associate Professor of Ophthalmology at Università della Campania, Luigi Vanvitelli, Napoli, Italy. His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. He has also edited two international books and authored more than 150 communications or posters for the most important international and Italian ophthalmology conferences.",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}]},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null}]},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}]}]},openForSubmissionBooks:{},onlineFirstChapters:{},subseriesFiltersForOFChapters:[],publishedBooks:{},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. Neiva",profilePictureURL:"https://mts.intechopen.com/storage/users/213786/images/system/213786.png",institutionString:null,institution:{name:"University of Beira Interior",institutionURL:null,country:{name:"Portugal"}}},{id:"39275",title:"Prof.",name:"Herbert Ryan",middleName:null,surname:"Marini",slug:"herbert-ryan-marini",fullName:"Herbert Ryan Marini",profilePictureURL:"https://mts.intechopen.com/storage/users/39275/images/9459_n.jpg",institutionString:null,institution:{name:"University of Messina",institutionURL:null,country:{name:"Italy"}}},{id:"196218",title:"Dr.",name:"Pasquale",middleName:null,surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci",profilePictureURL:"https://mts.intechopen.com/storage/users/196218/images/system/196218.png",institutionString:null,institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}]},onlineFirstChapters:{paginationCount:13,paginationItems:[{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. Drury",slug:"new-and-emerging-technologies-for-integrative-ambulatory-autonomic-assessment-and-intervention-as-a-",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"81286",title:"Potassium Derangements: A Pathophysiological Review, Diagnostic Approach, and Clinical Management",doi:"10.5772/intechopen.103016",signatures:"Sairah Sharif and Jie Tang",slug:"potassium-derangements-a-pathophysiological-review-diagnostic-approach-and-clinical-management",totalDownloads:24,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80895",title:"Heart Rate Variability as a Marker of Homeostatic Level",doi:"10.5772/intechopen.102500",signatures:"Moacir Fernandes de Godoy and Michele Lima Gregório",slug:"heart-rate-variability-as-a-marker-of-homeostatic-level",totalDownloads:25,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Moacir",surname:"Godoy"},{name:"Michele",surname:"Gregório"}],book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80433",title:"Heart Autonomic Nervous System: Basic Science and Clinical Implications",doi:"10.5772/intechopen.101718",signatures:"Elvan Wiyarta and Nayla Karima",slug:"heart-autonomic-nervous-system-basic-science-and-clinical-implications",totalDownloads:49,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80316",title:"Central Control of the Larynx in Mammals",doi:"10.5772/intechopen.102009",signatures:"Manuel Víctor López-González, Marta González-García, Laura Carrillo-Franco, Amelia Díaz-Casares and Marc Stefan Dawid-Milner",slug:"central-control-of-the-larynx-in-mammals",totalDownloads:36,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80402",title:"General Anesthesia and Autonomic Nervous System: Control and Management in Neurosurgery",doi:"10.5772/intechopen.101829",signatures:"Irina Alexandrovna Savvina, Anna Olegovna Petrova and Yulia Mikhailovna Zabrodskaya",slug:"general-anesthesia-and-autonomic-nervous-system-control-and-management-in-neurosurgery",totalDownloads:58,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80035",title:"Healthy Lifestyle, Autonomic Nervous System Activity, and Sleep Status for Healthy Aging",doi:"10.5772/intechopen.101837",signatures:"Miki Sato, Feni Betriana, Ryuichi Tanioka, Kyoko Osaka, Tetsuya Tanioka and Savina Schoenhofer",slug:"healthy-lifestyle-autonomic-nervous-system-activity-and-sleep-status-for-healthy-aging",totalDownloads:60,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80175",title:"Signaling Pathways Regulating Axogenesis and Dendritogenesis in Sympathetic Neurons",doi:"10.5772/intechopen.102442",signatures:"Vidya Chandrasekaran",slug:"signaling-pathways-regulating-axogenesis-and-dendritogenesis-in-sympathetic-neurons",totalDownloads:66,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Vidya",surname:"Chandrasekaran"}],book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80176",title:"Impacts of Environmental Stressors on Autonomic Nervous System",doi:"10.5772/intechopen.101842",signatures:"Mayowa Adeniyi",slug:"impacts-of-environmental-stressors-on-autonomic-nervous-system",totalDownloads:66,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"79655",title:"The Autonomic Nervous System, Sex Differences, and Chronobiology under General Anesthesia in In Vivo Experiments Involving Rats",doi:"10.5772/intechopen.101075",signatures:"Pavol Svorc Jr and Pavol Svorc",slug:"the-autonomic-nervous-system-sex-differences-and-chronobiology-under-general-anesthesia-in-in-vivo-e",totalDownloads:91,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"79194",title:"Potassium in Solid Cancers",doi:"10.5772/intechopen.101108",signatures:"Jessica Iorio, Lisa Lastraioli and Elena Lastraioli",slug:"potassium-in-solid-cancers",totalDownloads:119,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"78820",title:"Potassium Homeostasis",doi:"10.5772/intechopen.100368",signatures:"Shakuntala S. Patil and Sachin M. Patil",slug:"potassium-homeostasis",totalDownloads:108,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"78193",title:"Potassium and Cardiac Surgery",doi:"10.5772/intechopen.99735",signatures:"Shawn Kant, Frank W. Sellke and Jun Feng",slug:"potassium-and-cardiac-surgery",totalDownloads:175,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}}]},publishedBooks:{},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.jpg",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/187181",hash:"",query:{},params:{id:"187181"},fullPath:"/profiles/187181",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()