More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\n
Additionally, each book published by IntechOpen contains original content and research findings.
\\n\\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\n
Simba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\n
IntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\n
Since the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\n
Additionally, each book published by IntechOpen contains original content and research findings.
\n\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n
\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10076",leadTitle:null,fullTitle:"Quantum Mechanics",title:"Quantum Mechanics",subtitle:null,reviewType:"peer-reviewed",abstract:"Quantum mechanics touches all areas of physics, chemistry, life sciences, and engineering. It has emerged as a tool for researching and developing new technology that has had a deep impact on modern life. An essential ingredient of quantum mechanics is the role of the observer and the duality between particle and wave properties of matter at very small scales. This book covers such topics as complex space forms of quantum mechanics, entropy in quantum mechanics, and equations of relativistic quantum mechanics as well as applications of quantum mechanics to more complicated situations. Written by international experts, the book illustrates the wide scope, influence, and applicability of quantum mechanics.",isbn:"978-1-83968-045-8",printIsbn:"978-1-83968-044-1",pdfIsbn:"978-1-83968-046-5",doi:"10.5772/intechopen.87908",price:119,priceEur:129,priceUsd:155,slug:"quantum-mechanics",numberOfPages:274,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"78f2b316d6bb97464dbbf9b683164aff",bookSignature:"Paul Bracken",publishedDate:"October 14th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/10076.jpg",numberOfDownloads:6778,numberOfWosCitations:1,numberOfCrossrefCitations:2,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:2,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:5,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 11th 2019",dateEndSecondStepPublish:"March 5th 2020",dateEndThirdStepPublish:"May 4th 2020",dateEndFourthStepPublish:"July 23rd 2020",dateEndFifthStepPublish:"September 21st 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"92883",title:"Prof.",name:"Paul",middleName:null,surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken",profilePictureURL:"https://mts.intechopen.com/storage/users/92883/images/system/92883.jpg",biography:"Professor Paul Bracken is currently a Professor in the Department of Mathematics, at the University of Texas RGV in Edinburg, TX. He obtained his BSc degree from the University of Toronto and holds a Ph.D. from the University of Waterloo in Canada. His research interests include mathematical problems from the area of quantum mechanics and quantum field theory, differential geometry, a study of partial differential equations as well as their overlap with other problems in physics. He has published more than 180 papers in journals and books and has given many talks at different levels over the years. This is the seventh volume he has worked on with IntechOpen publishers.",institutionString:"The University of Texas Rio Grande Valley",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"10",totalChapterViews:"0",totalEditedBooks:"7",institution:{name:"The University of Texas Rio Grande Valley",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"230",title:"Quantum Mechanics",slug:"quantum-mechanics"}],chapters:[{id:"71547",title:"Dipolar Interactions: Hyperfine Structure Interaction and Fine Structure Interactions",doi:"10.5772/intechopen.91791",slug:"dipolar-interactions-hyperfine-structure-interaction-and-fine-structure-interactions",totalDownloads:636,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The interaction between the nuclear spin and the electron spin creates a hyperfine structure. Hyperfine structure interaction occurs in paramagnetic structures with unpaired electrons. Therefore, hyperfine structure interaction is the most important of the fundamental parameters investigated by electron paramagnetic resonance (EPR) spectroscopy. For EPR spectroscopy the two effective Hamiltonian terms are the hyperfine structure interaction and the electronic Zeeman interaction. The hyperfine structure interaction has two types as isotropic and anisotropic hyperfine structure interactions. The zero-field splitting term (electronic quadrupole fine structure), the nuclear Zeeman term, and the nuclear quadrupole interaction term are among the Hamiltonian terms used in EPR. However, their effects are not as much as the term of the hyperfine structure interaction. The zero-field splitting term and the nuclear quadrupole interaction term are the fine structure terms. The interaction of two electron spins create a zero-field splitting, the interaction between the two nucleus spins form the nuclear quadrupole interaction. Hyperfine structure interaction, zero-field interaction, and nuclear quadrupole interaction are subclasses of dipolar interaction. Interaction tensors are available for all three interactions.",signatures:"Betül Çalişkan and Ali Cengiz Çalişkan",downloadPdfUrl:"/chapter/pdf-download/71547",previewPdfUrl:"/chapter/pdf-preview/71547",authors:[{id:"199110",title:"Dr.",name:"Betül",surname:"Çalişkan",slug:"betul-caliskan",fullName:"Betül Çalişkan"},{id:"208732",title:"Dr.",name:"Ali Cengiz",surname:"Çalişkan",slug:"ali-cengiz-caliskan",fullName:"Ali Cengiz Çalişkan"}],corrections:null},{id:"73016",title:"Exactly Solvable Problems in Quantum Mechanics",doi:"10.5772/intechopen.93317",slug:"exactly-solvable-problems-in-quantum-mechanics",totalDownloads:709,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Some of the problems in quantum mechanics can be exactly solved without any approximation. Some of the exactly solvable problems are discussed in this chapter. Broadly there are two main approaches to solve such problems. They are (i) based on the solution of the Schrödinger equation and (ii) based on operators. The normalized eigen function, eigen values, and the physical significance of some of the selected problems are discussed.",signatures:"Lourdhu Bruno Chandrasekar, Kanagasabapathi Gnanasekar and Marimuthu Karunakaran",downloadPdfUrl:"/chapter/pdf-download/73016",previewPdfUrl:"/chapter/pdf-preview/73016",authors:[{id:"239576",title:"Dr.",name:"Marimuthu",surname:"Karunakaran",slug:"marimuthu-karunakaran",fullName:"Marimuthu Karunakaran"},{id:"252354",title:"Dr.",name:"Bruno Chandrasekar",surname:"L",slug:"bruno-chandrasekar-l",fullName:"Bruno Chandrasekar L"},{id:"325784",title:"Dr.",name:"K",surname:"Gnanasekar",slug:"k-gnanasekar",fullName:"K Gnanasekar"}],corrections:null},{id:"71655",title:"Transitions between Stationary States and the Measurement Problem",doi:"10.5772/intechopen.91801",slug:"transitions-between-stationary-states-and-the-measurement-problem",totalDownloads:635,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Accounting for projections during measurements is the traditional measurement problem. Transitions between stationary states require measurements, posing a different measurement problem. Both are compared. Several interpretations of quantum mechanics attempting to solve the traditional measurement problem are summarized. A highly desirable aim is to account for both problems. Not every interpretation of quantum mechanics achieves this goal.",signatures:"María Esther Burgos",downloadPdfUrl:"/chapter/pdf-download/71655",previewPdfUrl:"/chapter/pdf-preview/71655",authors:[{id:"96880",title:"Prof.",name:"Maria Esther",surname:"Burgos",slug:"maria-esther-burgos",fullName:"Maria Esther Burgos"}],corrections:null},{id:"71964",title:"Uncertainty Relations",doi:"10.5772/intechopen.92137",slug:"uncertainty-relations",totalDownloads:416,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Uncertainty relations are inequalities representing the impossibility of simultaneous measurement in quantum mechanics. The most well-known uncertainty relations were presented by Heisenberg and Schrödinger. In this chapter, we generalize and extend them to produce several types of uncertainty relations.",signatures:"Kenjiro Yanagi",downloadPdfUrl:"/chapter/pdf-download/71964",previewPdfUrl:"/chapter/pdf-preview/71964",authors:[{id:"315022",title:"Prof.",name:"Kenjiro",surname:"Yanagi",slug:"kenjiro-yanagi",fullName:"Kenjiro Yanagi"}],corrections:null},{id:"71370",title:"Complex Space Nature of the Quantum World: Return Causality to Quantum Mechanics",doi:"10.5772/intechopen.91669",slug:"complex-space-nature-of-the-quantum-world-return-causality-to-quantum-mechanics",totalDownloads:1002,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"As one chapter, we about to begin a journey with exploring the limitation of the causality that rules the whole universe. Quantum mechanics is established on the basis of the phenomenology and the lack of ontology builds the wall which blocks the causality. It is very difficult to reconcile the probability and the causality in such a platform. A higher dimension consideration may leverage this dilemma by expanding the vision. Information may seem to be discontinuous or even so weird if only be viewed from a part of the degree of freedoms. Based on this premise, we reexamined the microscopic world within a complex space. Significantly, some knowledge beyond the empirical findings is revealed and paves the way for a more detailed exploration of the quantum world. The random quantum motion is essential for atomic particle and exhibits a wave-related property with a bulk of trajectories. It seems we can break down the wall which forbids the causality entering the quantum kingdom and connect quantum mechanics with classical mechanics. The causality returns to the quantum world without any assumption in terms of the quantum random motion under the optimal guidance law in complex space. Thereby hangs a tale, we briefly introduce this new formulation from the fundamental theoretical description to the practical technology applications.",signatures:"Ciann-Dong Yang and Shiang-Yi Han",downloadPdfUrl:"/chapter/pdf-download/71370",previewPdfUrl:"/chapter/pdf-preview/71370",authors:[{id:"158670",title:"Prof.",name:"Ciann-Dong",surname:"Yang",slug:"ciann-dong-yang",fullName:"Ciann-Dong Yang"},{id:"315900",title:"Dr.",name:"Shiang-Yi",surname:"Han",slug:"shiang-yi-han",fullName:"Shiang-Yi Han"}],corrections:null},{id:"71814",title:"Entropy in Quantum Mechanics and Applications to Nonequilibrium Thermodynamics",doi:"10.5772/intechopen.91831",slug:"entropy-in-quantum-mechanics-and-applications-to-nonequilibrium-thermodynamics",totalDownloads:668,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Classical formulations of the entropy concept and its interpretation are introduced. This is to motivate the definition of the quantum von Neumann entropy. Some general properties of quantum entropy are developed, such as the quantum entropy which always increases. The current state of the area that includes thermodynamics and quantum mechanics is reviewed. This interaction shall be critical for the development of nonequilibrium thermodynamics. The Jarzynski inequality is developed in two separate but related ways. The nature of irreversibility and its role in physics are considered as well. Finally, a specific quantum spin model is defined and is studied in such a way as to illustrate many of the subjects that have appeared.",signatures:"Paul Bracken",downloadPdfUrl:"/chapter/pdf-download/71814",previewPdfUrl:"/chapter/pdf-preview/71814",authors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],corrections:null},{id:"73269",title:"Equations of Relativistic and Quantum Mechanics (without Spin)",doi:"10.5772/intechopen.93336",slug:"equations-of-relativistic-and-quantum-mechanics-without-spin-",totalDownloads:449,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"A relativistically invariant representation of the generalized momentum of a particle in an external field is proposed. In this representation, the dependence of the potentials of the interaction of the particle with the field on the particle velocity is taken into account. The exact correspondence of the expressions of energy and potential energy for the classical Hamiltonian is established, which makes identical the solutions to the problems of mechanics with relativistic and nonrelativistic approaches. The invariance of the proposed representation of the generalized momentum makes it possible to equivalently describe a physical system in geometrically conjugate spaces of kinematic and dynamic variables. Relativistic invariant equations are proposed for the action function and the wave function based on the invariance of the representation of the generalized momentum. The equations have solutions for any values of the constant interaction of the particle with the field, for example, in the problem of a hydrogen-like atom, when the atomic number of the nucleus is Z > 137. Based on the parametric representation of the action, the expression for the canonical Lagrangian, the equations of motion, and the expression for the force acting on the charge are derived when moving in an external electromagnetic field. The Dirac equation with the correct inclusion of the interaction for a particle in an external field is presented. In this form, the solutions of the equations are not limited by the value of the interaction constant. The solutions of the problem of charge motion in a constant electric field, the problems for a particle in a potential well and the passage of a particle through a potential barrier, the problems of motion in an exponential field (Morse), and also the problems of a hydrogen atom are given.",signatures:"Vahram Mekhitarian",downloadPdfUrl:"/chapter/pdf-download/73269",previewPdfUrl:"/chapter/pdf-preview/73269",authors:[{id:"315832",title:"Dr.",name:"Vahram",surname:"Mekhitarian",slug:"vahram-mekhitarian",fullName:"Vahram Mekhitarian"}],corrections:null},{id:"73120",title:"Nature of Temporal (t > 0) Quantum Theory: Part I",doi:"10.5772/intechopen.93561",slug:"nature-of-temporal-t-0-quantum-theory-part-i",totalDownloads:434,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"It is our science governs the mathematics and it is “not” our mathematics governs our science. One of the very important aspects is that every science has to comply with the boundary condition of our universe; dimensionality and temporal (t > 0) or causality. In which I have shown that time is real and it is not an illusion, since every aspect within our universe is coexisted with time. Since our universe is a temporal (t > 0) subspace, everything within our universe is temporal. Science is mathematics but mathematics is not science, we have shown that any analytic solution has to be temporal (t > 0); otherwise, it cannot be implemented within our universe. Which includes all the laws, principles, and theories have to be temporal? Uncertainty principle is one of the most fascinated principles in quantum mechanics, yet Heisenberg principle was based on diffraction limited observation, it is not due to the nature of time. We have shown it is the temporal (t > 0) uncertainty that changes with time. We have introduced a certainty principle as in contrast with uncertainty principle. Of which certainty subspace can be created within our universe; which can be exploited for application. Overall of this chapter is to show that; it is not how rigorous the mathematics is, it is the physical realizable paradigm that we embrace.",signatures:"Francis T.S. Yu",downloadPdfUrl:"/chapter/pdf-download/73120",previewPdfUrl:"/chapter/pdf-preview/73120",authors:[{id:"300154",title:"Emeritus Prof.",name:"Francis",surname:"Yu",slug:"francis-yu",fullName:"Francis Yu"}],corrections:null},{id:"73158",title:"Nature of Temporal (t > 0) Quantum Theory: Part II",doi:"10.5772/intechopen.93562",slug:"nature-of-temporal-t-0-quantum-theory-part-ii",totalDownloads:424,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Since Schrödinger’s quantum mechanics developed from Hamiltonian, I will show that his quantum machine is a timeless (t = 0) mechanics, which includes his fundamental principle of superposition. Since one of the most controversial paradoxes in science must be Schrödinger’s cat. We will show that the myth of his hypothesis is “not” a physical realizable postulation. The most important aspect in quantum theory must be the probabilistic implication of science, a set of most elegant and simple laws and principles, which will be discussed. Since information and entropy have a profound connection, we will show that information is one of very important science in quantum theory, for which several significant aspects of information transmission will be stressed. Nevertheless, the myth of quantum theory turns out to be not Schrodinger’s cat but the nature of a section of time Δt. Since time is a quantity that we cannot physically manipulate, we could change the section Δt but not the speed of time. Although we can squeeze a section of Δt, but we cannot squeeze Δt to zero. And this is the ultimate quantum limit of “instantaneous” response we can never be able to obtain. Since time traveling is one of the very interesting topics in science, I will show that time traveling is impossible even at the speed of light. Nevertheless, I will show quantum mechanics is a temporal (t > 0) physical realizable mechanics, and it should “not” be as virtual and timeless (t = 0) as mathematic does.",signatures:"Francis T.S. Yu",downloadPdfUrl:"/chapter/pdf-download/73158",previewPdfUrl:"/chapter/pdf-preview/73158",authors:[{id:"300154",title:"Emeritus Prof.",name:"Francis",surname:"Yu",slug:"francis-yu",fullName:"Francis Yu"}],corrections:null},{id:"72922",title:"Analysis of Quantum Confinement and Carrier Transport of Nano-Transistor in Quantum Mechanics",doi:"10.5772/intechopen.93258",slug:"analysis-of-quantum-confinement-and-carrier-transport-of-nano-transistor-in-quantum-mechanics",totalDownloads:623,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Quantum mechanics is the branch of physics that consists of laws explaining the physical properties of the nature of nano-particles and their characteristics on an atomic scale. The study of nano-particles significantly challenges our current perception of the universe and the fabric of reality itself. Quantum particles have both wave-like and particle-like characteristics. The fundamental equation that predicts the physical behaviour of a quantum system is the Schrödinger equation and the Poisson equation using Monte Carlo simulations. This gives rise to the wavefunction, electron and hole densities, energy levels and band structure of the system which contains all the measurable information about the particle such as time and position, where position is represented using probabilities. This is because particles do not have one definite position during the time before measurement. In fact, they exist as a fuzzy distribution of all possible states where the likelihood of finding the particle in some states is more probable than others. This is known as being in a superposition of all states. When the quantum system is observed, however, its wavefunction collapses so it consequently falls into one specific position. Moreover, in this chapter we present the simulation results of conduction band profile, electron density (classical and quantum mechanical), eigenstate and eigenfunctions for Si, SOI and III-V MOSFET structures at bias voltage 1.0 V using 1D Poisson-Schrödinger solver.",signatures:"Aynul Islam and Anika Tasnim Aynul",downloadPdfUrl:"/chapter/pdf-download/72922",previewPdfUrl:"/chapter/pdf-preview/72922",authors:[{id:"316001",title:"Dr.",name:"Islam",surname:"Aynul",slug:"islam-aynul",fullName:"Islam Aynul"},{id:"325161",title:"BSc.",name:"Anika Tasnim",surname:"Aynul",slug:"anika-tasnim-aynul",fullName:"Anika Tasnim Aynul"}],corrections:null},{id:"72779",title:"Development of Supersymmetric Background/Local Gauge Field Theory of Nucleon Based on Coupling of Electromagnetism with the Nucleon’s Background Space-Time Frame: The Physics beyond the Standard Model",doi:"10.5772/intechopen.93087",slug:"development-of-supersymmetric-background-local-gauge-field-theory-of-nucleon-based-on-coupling-of-el",totalDownloads:376,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"A new reformulated gauge field theory comprising discrete super symmetry matrixes U (1) = SU (2) + SO (3) has been developed which explains why all the elementary particles appear in three families with very similar structures. The three families’ performance is the product of discrete conservation of energy—momentum eigenvalue Es = 1/2Ea within space–time frame which appears to be the genetic code of new physics. A new supersymmetric gauge field theory of photon was developed, which describes fundamental conservation laws through invariant translation of the discrete symmetries of nature. A new gauge theory describes all the fundamental laws through isomorphism of the discrete space–time SU (2) frame and energy-momentum SO (3) symmetry group. Coupling of space and time phases of energy conservation generates the background gauge field, which in conjugation with the local gauge field mediates discrete performance of three fractional proton-neutron families of baryon structure. The presented theory requires to have a new look to our understanding of symmetry and conservation laws.",signatures:"Aghaddin Mamedov",downloadPdfUrl:"/chapter/pdf-download/72779",previewPdfUrl:"/chapter/pdf-preview/72779",authors:[{id:"219617",title:"Dr.",name:"Aghaddin",surname:"Mamedov",slug:"aghaddin-mamedov",fullName:"Aghaddin Mamedov"}],corrections:null},{id:"72806",title:"Realization of the Quantum Confinement",doi:"10.5772/intechopen.93112",slug:"realization-of-the-quantum-confinement",totalDownloads:406,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this chapter the three main technologies are described, which allows for the implementation of quantum structures (QS)—quantum wells (QWs) and hetero-structures. These are liquid phase epitaxy (LPE), molecular beam epitaxy (MBE), and metal-organic chemical vapor deposition (MOCVD). The most important properties, including the quantum Hall effect (QHE), of two-dimensional electron gas (2DEG) arising in a heterojunction on the boundary of two phases—the so-called interface—are also presented. The 2DEG properties in different kinds of QW are described. Double quantum wells as interesting example of quantum structure is considered also including such a spectacular quantum-mechanical phenomenon as splitting into symmetrical and anti-symmetrical states.",signatures:"Eugen M. Sheregii",downloadPdfUrl:"/chapter/pdf-download/72806",previewPdfUrl:"/chapter/pdf-preview/72806",authors:[{id:"102655",title:"Prof.",name:"Eugen",surname:"Sheregii",slug:"eugen-sheregii",fullName:"Eugen Sheregii"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"3513",title:"Advances in Quantum Mechanics",subtitle:null,isOpenForSubmission:!1,hash:"bbea1c081216f267a4480707f4ead9cf",slug:"advances-in-quantum-mechanics",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/3513.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5488",title:"Manifolds",subtitle:"Current Research Areas",isOpenForSubmission:!1,hash:"e1193790ca2c8027d4ffc6911dd24365",slug:"manifolds-current-research-areas",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/5488.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5213",title:"Research Advances in Quantum Dynamics",subtitle:null,isOpenForSubmission:!1,hash:"15678b0555c714101f8d707a46b4ac60",slug:"research-advances-in-quantum-dynamics",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/5213.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10413",title:"A Collection of Papers on Chaos Theory and Its Applications",subtitle:null,isOpenForSubmission:!1,hash:"900b71b164948830fec3d6254b7881f7",slug:"a-collection-of-papers-on-chaos-theory-and-its-applications",bookSignature:"Paul Bracken and Dimo I. Uzunov",coverURL:"https://cdn.intechopen.com/books/images_new/10413.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7776",title:"Research Advances in Chaos Theory",subtitle:null,isOpenForSubmission:!1,hash:"e9646ec4b2bff873ce958ed4d5ad7248",slug:"research-advances-in-chaos-theory",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/7776.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7342",title:"Manifolds II",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:"97f5bd89a6e5006ea10d90df5a6df5a5",slug:"manifolds-ii-theory-and-applications",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/7342.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7396",title:"Panorama of Contemporary Quantum Mechanics",subtitle:"Concepts and Applications",isOpenForSubmission:!1,hash:"e78f2cfea2dec9fab1f269c994faa0d4",slug:"panorama-of-contemporary-quantum-mechanics-concepts-and-applications",bookSignature:"Tuong T. Truong",coverURL:"https://cdn.intechopen.com/books/images_new/7396.jpg",editedByType:"Edited by",editors:[{id:"143434",title:"Prof.",name:"Trong Tuong",surname:"Truong",slug:"trong-tuong-truong",fullName:"Trong Tuong Truong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10209",title:"Quantum Computing and Communications",subtitle:null,isOpenForSubmission:!1,hash:"588d044631767881b7490cd9cb2c052b",slug:"quantum-computing-and-communications",bookSignature:"Yongli Zhao",coverURL:"https://cdn.intechopen.com/books/images_new/10209.jpg",editedByType:"Edited by",editors:[{id:"199527",title:"Associate Prof.",name:"Yongli",surname:"Zhao",slug:"yongli-zhao",fullName:"Yongli Zhao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10674",title:"Topics on Quantum Information Science",subtitle:null,isOpenForSubmission:!1,hash:"d7481712cff0157cd8f849cba865727d",slug:"topics-on-quantum-information-science",bookSignature:"Sergio Curilef and Angel Ricardo Plastino",coverURL:"https://cdn.intechopen.com/books/images_new/10674.jpg",editedByType:"Edited by",editors:[{id:"125424",title:"Prof.",name:"Sergio",surname:"Curilef",slug:"sergio-curilef",fullName:"Sergio Curilef"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"65667",slug:"erratum-the-roll-of-the-entrepreneur-in-the-establishment-of-economic-equilibria",title:"Erratum - The Roll of the Entrepreneur in the Establishment of Economic Equilibria",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/65667.pdf",downloadPdfUrl:"/chapter/pdf-download/65667",previewPdfUrl:"/chapter/pdf-preview/65667",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/65667",risUrl:"/chapter/ris/65667",chapter:{id:"57461",slug:"the-roll-of-the-entrepreneur-in-the-establishment-of-economic-equilibria",signatures:"Er’el Granot",dateSubmitted:"April 7th 2017",dateReviewed:"August 22nd 2017",datePrePublished:"December 20th 2017",datePublished:"January 24th 2018",book:{id:"6165",title:"Entrepreneurship",subtitle:"Development Tendencies and Empirical Approach",fullTitle:"Entrepreneurship - Development Tendencies and Empirical Approach",slug:"entrepreneurship-development-tendencies-and-empirical-approach",publishedDate:"January 24th 2018",bookSignature:"Ladislav Mura",coverURL:"https://cdn.intechopen.com/books/images_new/6165.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"85474",title:"Associate Prof.",name:"Ladislav",middleName:null,surname:"Mura",slug:"ladislav-mura",fullName:"Ladislav Mura"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"181601",title:"Prof.",name:"Er'El",middleName:null,surname:"Granot",fullName:"Er'El Granot",slug:"er'el-granot",email:"erelgranot@gmail.com",position:null,institution:{name:"Ariel University",institutionURL:null,country:{name:"Israel"}}}]}},chapter:{id:"57461",slug:"the-roll-of-the-entrepreneur-in-the-establishment-of-economic-equilibria",signatures:"Er’el Granot",dateSubmitted:"April 7th 2017",dateReviewed:"August 22nd 2017",datePrePublished:"December 20th 2017",datePublished:"January 24th 2018",book:{id:"6165",title:"Entrepreneurship",subtitle:"Development Tendencies and Empirical Approach",fullTitle:"Entrepreneurship - Development Tendencies and Empirical Approach",slug:"entrepreneurship-development-tendencies-and-empirical-approach",publishedDate:"January 24th 2018",bookSignature:"Ladislav Mura",coverURL:"https://cdn.intechopen.com/books/images_new/6165.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"85474",title:"Associate Prof.",name:"Ladislav",middleName:null,surname:"Mura",slug:"ladislav-mura",fullName:"Ladislav Mura"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"181601",title:"Prof.",name:"Er'El",middleName:null,surname:"Granot",fullName:"Er'El Granot",slug:"er'el-granot",email:"erelgranot@gmail.com",position:null,institution:{name:"Ariel University",institutionURL:null,country:{name:"Israel"}}}]},book:{id:"6165",title:"Entrepreneurship",subtitle:"Development Tendencies and Empirical Approach",fullTitle:"Entrepreneurship - Development Tendencies and Empirical Approach",slug:"entrepreneurship-development-tendencies-and-empirical-approach",publishedDate:"January 24th 2018",bookSignature:"Ladislav Mura",coverURL:"https://cdn.intechopen.com/books/images_new/6165.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"85474",title:"Associate Prof.",name:"Ladislav",middleName:null,surname:"Mura",slug:"ladislav-mura",fullName:"Ladislav Mura"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11714",leadTitle:null,title:"Cannabinoids - Recent Perspectives and Applications in Human Health",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tThere is a great deal of confusion and controversy regarding Cannabinoids. The term "Cannabinoids" is applied to multiple chemical entities and their derivatives and metabolites isolated from the plant Cannabis sativa. Over 100 cannabinoids have been isolated to date and more are likely to be identified. Currently, they are classified into 11 different families and include delta-9 tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabigerol (CBG), Cannabichromene (CBC), and many others. Although used for varied purposes over human history, there is now great interest in the potential use of cannabinoids as novel medical therapeutics.
\r\n
\r\n\tThis book will discuss how these-plant derived compounds may potentially influence human health by interaction with the internal endocannabinoid system of animals. The evolution of cannabinoids in Cannabis sativa in the plant kingdom is separate from the development of the endocannabinoid system. These parallel histories led to the discovery that the biological activities of cannabinoids occurred through an accidental interaction with the endocannabinoid system.
\r\n
\r\n\tThis book explores the pressing controversy of whether cannabinoids enhance, or disrupt, critical physical activities essential to human health. From this discussion, the book will enable the reader to decide if cannabinoids present a promise of discoveries that lead to improved better therapeutics or a threat to the homeostasis critical for health.
",isbn:"978-1-80356-579-8",printIsbn:"978-1-80356-578-1",pdfIsbn:"978-1-80356-580-4",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"535e6d9b6681d78abcd0b68e02ed9bdd",bookSignature:"Dr. Steven P. James",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11714.jpg",keywords:"Cannabis, Delta-9 Tetrahydrocannabinoid (THC), Cannabidiol (CBD), Medical Marijuana, Cannabinoid 1 Receptor (CB1), Cannabinoid 2 Receptor (CB2), Anandamide (AEA), 2-Arachidonylglycerol (2-AG), K2, Nabilone, Psychedelic, Spice",numberOfDownloads:1,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 15th 2022",dateEndSecondStepPublish:"May 24th 2022",dateEndThirdStepPublish:"July 23rd 2022",dateEndFourthStepPublish:"October 11th 2022",dateEndFifthStepPublish:"December 10th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. James trained in Psychiatry at The New York Hospital, Cornell University, Westchester Division followed by a Psychopharmacology fellowship at Stanford University and a Research fellowship at the National Institute of Mental Health. After leaving his academic career, he pursued his interest in research and psychopharmacology within the pharmaceutical industry for over 20 years. He is a Fellow of both the American Psychiatric Association (APA) and the American Board of Sleep Medicine (ABSM).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"343012",title:"Dr.",name:"Steven P.",middleName:null,surname:"James",slug:"steven-p.-james",fullName:"Steven P. James",profilePictureURL:"https://mts.intechopen.com/storage/users/343012/images/system/343012.png",biography:"Steven James is the author of the recent book 'The Clinician's Guide to Cannabinoid Science' and advises pharmaceutical and health care providers on the clinical development of cannabinoid medications and their clinical uses. A cofounder of Clarity Telehealth, Dr James serves as Chief Medical Officer (CMO) and is a distinguished lifetime fellow of the American Board of Psychiatry and Neurology, and lifetime fellow of the American Board of Sleep Medicine.\nBefore publishing 'The Clinician's Guide to Cannabinoid Science', Dr. James worked for over three decades in the pharmaceutical and medical device industries including Lilly, Merck-Serono and Allergan. Before starting his career in pharmaceuticals, he trained in psychiatry at the New York-Presbyterian/Weill Cornell Medical Center and research fellowship at Stanford University School of Medicine. After training he served for three years at the National Institute of Mental Health (NIMH) and as an assistant professor at the University of Pennsylvania School of Medicine.",institutionString:null,position:null,outsideEditionCount:null,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of California, San Diego",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:[{id:"82345",title:"Cannabis Medicines: Guidance for the Selection, Purchase and Supply for Clinical Trials",slug:"cannabis-medicines-guidance-for-the-selection-purchase-and-supply-for-clinical-trials",totalDownloads:1,totalCrossrefCites:0,authors:[null]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"453622",firstName:"Tea",lastName:"Jurcic",middleName:null,title:"Ms.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"tea@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. Mauricio Barría",coverURL:"https://cdn.intechopen.com/books/images_new/6550.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. Mauricio Barría"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9500",title:"Recent Advances in Bone Tumours and Osteoarthritis",subtitle:null,isOpenForSubmission:!1,hash:"ea4ec0d6ee01b88e264178886e3210ed",slug:"recent-advances-in-bone-tumours-and-osteoarthritis",bookSignature:"Hiran Amarasekera",coverURL:"https://cdn.intechopen.com/books/images_new/9500.jpg",editedByType:"Edited by",editors:[{id:"67634",title:"Dr.",name:"Hiran",surname:"Amarasekera",slug:"hiran-amarasekera",fullName:"Hiran Amarasekera"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"69846",title:"Orthognathic Surgery in Cleft Lip and Palate Patients",doi:"10.5772/intechopen.89556",slug:"orthognathic-surgery-in-cleft-lip-and-palate-patients",body:'\n
\n
1. Introduction
\n
Deficiency of growth and development in the midfacial complex is a major drawback of primary CLP repair in the neonatal period of growth, well documented in the literature [1, 2, 3]. Causes are thought to be formation of scar tissue in the growth centers of the maxilla [4], mouth breathing due to obstruction of the nasal passage [5], deficiency of the alveolar process due to missing teeth [6], and a tense upper lip [7, 8]. Unrepaired bone defects on the other hand result in closer to normal maxillo-facial development [7, 8]. Because of midfacial deficiency, orthognathic surgery becomes often indispensable at the adult ages in CLP management. Treatment of CLP with orthognathic surgery involves maxillary advancement, distraction osteogenesis, and mandibular setback, combined with orthodontic treatment [9].
\n
\n
\n
2. Timing of orthognathic surgery
\n
In the past, CLP-orthognathic surgery in the mixed dentition period has been discussed and discarded. It has been reported that there will usually be a need for revisions after completion of skeletal growth [10]. Risks of early orthognathic surgery include damage to permanent tooth germs and creation of fibrous tissue and calli in the osteotomy regions. Additionally, it was shown that neither Le Fort I osteotomy nor distraction osteogenesis in the mixed dentition period provides additional lateral maxillary growth [11, 12]. Apart from cases with significant psychosocial or functional problems, risks of “early” surgery overweigh its benefits [13].
\n
Orthognathic surgery for treatment of maxillomandibular deformities is usually applied after completion of growth of the maxillomandibular structure [14, 15, 16]. Transverse, sagittal, and vertical growth of the maxilla and the mandible ends at different chronological ages, usually at the ages of 14–16 for female patients and 16–18 for male patients [17]. Mandibular growth has a normal pattern in most CLP patients [13]. However, since skeletal growth is variable, hand-wrist or cephalometric radiographs may help in determining the timing of skeletal maturation [17].
\n
\n
\n
3. Preparation for orthognathic surgery
\n
In orthognathic surgery in cleft patients, there are some issues that need to be considered before surgery like velopharyngeal situation, speech problems, hearing problems, the situation of alveolar cleft gap, and dental problems.
\n
Speech pathologists play a critical role in terms of assessing speech and articulation problems and determine velopharyngeal function with nasal endoscopy before the surgery [18, 19]. The velopharyngeal sufficiency rarely remains the same after maxillary advancement surgery; more often, an insufficiency is created [20]. Surgical correction of cross-bites and open-bites and the repair of cleft-dental gaps and residual oronasal fistulae usually alleviate articulation disorders [19, 21].
\n
Prevention and treatment of tympanic infection as well as comprehensive preventive and restorative dental care have been provided during early childhood and adolescence. Oral hygiene maintenance may be more difficult in CLP patients than in routine orthodontic treatment patients. Soft tissues may have a more retentive morphology due to scarring from previous operations: shallow buccal sulci, sometimes buccal flaps with mucosa or gingivae covering teeth. Furthermore, because of poor dental esthetics, CLP patients do not like their teeth and smile and have low motivation. Long treatment times reduce motivation further. Orthodontic preparation presents various challenges not only in terms of planning but also in terms of implementation. It may be difficult for the orthodontist to work in a narrow space with low visibility, since the elasticity of lips is low, mouth opening is limited, and the upper jaw is small and retrognathic. All surgical management of maxillo-mandibular deformities usually requires prior adjustment of the dental arches over the maxillary and mandibular basal bones via orthodontic treatment. The “surgery-first” protocol rarely applies to CLP patients. A major dilemma during alignment is the decision on the management of the cleft alveolar region, where often the lateral teeth are missing [6]. Surgical correction of septal and inferior respiratory pathologies is done only in severe obstructive sleep apnoea cases before orthognathic surgery, but rather scheduled to be performed simultaneously or consecutively [22, 23, 24].
\n
In most CLP cases, teeth are either missing, erupt late or ectopically located. Therefore, the alveolar bone base is not sufficiently developed, and this adds to the skeletal (transverse and sagittal) insufficiency. Leveling of teeth erupting in the palate usually takes a long time (\nFigure 1\n).
\n
Figure 1.
Teeth erupting from the palate [25]. (a) UCLP patient, permanent dentition. Missing lateral incisors, 15 and 23 erupting palatally, and 17 erupting excessively buccally. (b) Dental arch development through orthodontic leveling, occult fistula enlarged and became visible during dental leveling, 13 is just starting to erupt after 2.5 years of orthodontic treatment.
\n
\n
\n
4. Residual deformities in CLP patients
\n
Patients with Isolated Cleft Palate (ICP) have a complete alveolar ridge and generally a complete set of teeth [13, 17, 26, 27]. The main deformity in unilateral cleft lip and palate (UCLP) and bilateral cleft lip and palate (BCLP) patients is maxillary hypoplasia, but oronasal fistula, bony defects, intranasal obstruction, soft tissue scarring, and velopharyngeal dysfunctions are also frequently encountered [27]. Additionally, the maxillary lateral incisor and often the second premolars in the cleft region are either congenitally missing, resulting in a cleft-dental gap [6, 28, 29, 30].
\n
In addition to the existing deformities in UCLP and BCLP patients, nasal obstruction and sinus blockage and mandibular asymmetry and chin dysplasia are seen frequently as secondary deformities [27, 31]. The prevalence of these deformities varies significantly based on the surgical philosophy and experience of the surgeon who repaired the first cleft [32], the individual’s unique biological growth potential, and the level of care of the family/patient.
\n
Published clinical research on individuals who were born with complete UCLP/BCLP and treated at cleft centers showed that, despite the best efforts, the mixed dentition period would not be appropriate for grafting just before the canine tooth is erupted on the cleft side in some children [33, 34]. Additionally, although grafted appropriately, in some individuals, additional reconstruction is needed [33]. For these reasons, repairing residual skeletal and soft tissues and managing dental deformities in patients with CLP strains the proficiency and skills of the orthognathic surgery cleft team [26, 31, 35].
\n
\n
\n
5. Orthognathic approach on UCLP deformities
\n
\n
5.1 Prevalence
\n
Studies have examined the need for orthognathic surgery in UCLP patients who underwent primary lip-palate repair procedures in childhood [3, 8, 36, 37]. Ross [37] stated that the midface is close to normal only in 25% of patients, and there is a need for orthognathic surgery in the remaining patients, with interventions at early stages worsening the situation. In other similar studies, the rate of orthognathic surgery needed in repaired UCLP patients was 48–59.3% [3, 8].
\n
\n
\n
5.2 Orthodontic approach
\n
In adolescent or adult UCLP patients with maxillary hypoplasia and deficient bone grafts, there are two maxillary segments separated by the cleft. Each segment has varying degrees of dysplasia on the sagittal, vertical, and horizontal directions. Orthodontic treatment is carried out to both position the teeth perpendicular to the alveolar crest and level the alveolar segments using the teeth. Sometimes, it is not possible to achieve leveling of the bony segments, and it may be necessary to level the teeth into two separate segments, instead of a complete arch, and to prepare for leveling these segments by alveolar distraction osteogenesis or segmental orthognathic surgery (\nFigure 2\n).
\n
Figure 2.
UCLP patient [25]. A1-3: Before orthodontic preparation. Retrognathic and narrow maxilla, missing teeth (12, 22, 15 and 25), noticeable alveolar cleft, severe transverse and vertical dislocation of the smaller segment. B1-3: Orthodontic leveling of teeth in two separate segments. C1-3: Post-op continuous stainless-steel arch-wires. D1-3: Post-treatment vertical relapse to some extent.
\n
In cases that present with sufficient bone grafting during the mixed dentition period, the maxilla is a single segment, and the orthodontist would only adapt the dental arch form to the existing basal bone.
\n
There are substantial variations in the number of upper permanent incisors and the alveolar bone amount in the premaxilla of UCLP patients. The lateral incisor tooth on the cleft side was found normal in only 7% of UCLP cases [6], more frequently, when present, there are shape anomalies. In the presence of a weakly formed lateral incisor tooth, these teeth might need extraction for long-term functioning and better esthetics.
\n
Decision to extract the first premolar, which is another tooth near the cleft, is dependent on volume and height of the alveolar bone to accommodate the root of the canine adjacent to the cleft without irreversibly weakening its periodontal support, as well as the degree of crowding. Although extractions on the mandibular arch are sometimes obligatory due to crowding, extraction is usually not necessary in the mandibular arch. The disadvantage of closing a cleft-dental gap orthodontically or surgically is the shifting of the cleft segment toward the posterior, in a way that is the opposite of what is desired (to shifting forward of the posterior region).
\n
As mentioned above, after leveling and aligning teeth with orthodontic treatment, models prepared by digitally or by using plaster are transferred to computer software/articulators. On these models, the maxillomandibular relation and occlusion are adjusted to an ideal position, and the advancement of the maxilla, rotation/setback of the mandible and vertical and transversal dimension amounts are assessed. As a result of these arrangements, splints are fabricated to use as a guide in orthognathic surgery, and the desired effects almost completely reflected on the surgery.
\n
\n
\n
5.3 Surgical approach
\n
Due to the prevalence of maxillary osteotomy complications in UCLP patients [38], confusing and complicated orthognathic surgery techniques were proposed for these patients [39, 40, 41]. Moreover, as in other aspects of orthognathic surgery, Hugo Obwegeser also provided contributions that could be explained as breakthroughs for skeletally cleft reconstruction [35, 42, 43, 44]. Toward the end of 1960s, he managed to advance the cleft maxilla by up to 20 mm to a desired position without needing a complicated mandibular setback approach. Then, he noticed that down-fracture and adequate mobilization of the maxilla, regardless of the presence or absence of a cleft, were the key in maxillary advancement [35]. The success of this approach achieved by Obwegeser was confirmed when Bell showed supply blood circulation to the down-fractured maxillae in their animal studies [45].
\n
In the mid-1980s, Posnick used the Le Fort I techniques of Obwegeser for treatment of UCLP deformity and improved them [46]. The main issue was that the circumvestibular incision used by Obwegeser directly allowed dissection, osteotomies, disimpaction, fistula closure, septoplasty, inferior turbinate reduction, pyriform aperture recontouring, bone grafting, and application of plate and screw fixation. This was a reliable approach that did not have a circulation damage risk in smaller or larger flaps and had continuity [35]. Moreover, with the easiness of field of view provided by circumvestibular incision, it became possible to readily close the cleft-dental region by differential maxillary segmental repositioning without bone necrosis or loss of teeth. This method also closes the unoccupied space of the cleft, and at the same time, combines the labial and palatal flaps together without needing a subperiosteal undermining procedure, which allows closure of stubborn oronasal fistulae and establishment of periodontal health in the teeth adjacent to the cleft [35]. Today, although the surgical methods applied on UCLP patients differ depending on the success of grafting performed in the mixed dentition period, the main method are as follows:
\n
\n
5.3.1 Standard Le fort I osteotomy
\n
An adolescent or adult CLP patient who has maxillary deformity but no residual fistula, in addition to an intact alveolar ridge with an adequate height in the cleft region may have been born without an alveolar cleft or had a successful grafting procedure [42]. A standard Le Fort I osteotomy may be applied on individuals who have sufficient alveolar ridge height and volume, a close palate and sufficient periodontal support. Segmental maxillary osteotomy may also be needed in correction of arch width, repairing vertical dimensions or preventing the need for prosthetic lateral incisors by closing the cleft-dental gap.
\n
Unfortunately, even in the twenty-first century, alveolar defects and oronasal fistulae are encountered in many adults and adolescents who have UCLP with maxillary hypoplasia. For these patients, a modified Le Fort I osteotomy should be considered [17].
\n
\n
\n
5.3.2 Modified Le fort I osteotomy (two-segment)
\n
In UCLP patients, the gap of the missing lateral incisor tooth may be eliminated by advancement of the lateral alveolar bone segment, where the canine tooth is placed adjacent to the central incisor tooth. After this, the canine is formed in a similar appearance to that of the lateral incisor [47]. This method that was described by Obwegeser in cases of unilateral cleft was advanced by Posnick in 1992 and name as the modified Le Fort I osteotomy method [46].
\n
In the technique, first, a maxillary circumvestibular incision is made labially from a zygomatic buttress to another. In the residual oronasal fistula region, vertical incisions are made to separate the mucosa on both sides of the cleft as oral and nasal. These incisions are perpendicular to the horizontal vestibular incision, and they follow the line angles of the teeth adjacent to the cleft (central and canine). If the cleft bone was not previously repaired, the segments are already in two pieces with the down-fractured maxilla. If the maxilla is intact and the arch form needs to be adjusted, by using a reciprocating saw with a short and flat tip, the maxilla is divided into two pieces by cutting from the cleft area. The parts need to be brought closer to close the cleft-dental gap. However, this may be achieved only after shaving in the distal direction of the central incisor and along the mesial part of the canine from the alveola. Attention should be paid to ensure avoiding contact with the lamina dura as it would expose the root of teeth and may result in external root resorption. The maxillary segments are then stabilized with wires and acrylic occlusal splints. Repositioning of the segments closes the cleft-dental gap, gathers the alveolar ridges together, and gets the labial and palatal mucosal tissues closer for oral-fistula closure [17].
\n
The extent of the maxillary advancement that is carried out by the surgeon is based on previously planned occlusion, airway needs, and preoperatively determined facial esthetics. The ideal vertical dimension is achieved based on the preoperative plan, but intraoperative approaches may be considered in some cases [35]. Maxillary osteotomy regions are fixed on all zygomatic buttresses and apertures by using titanium plates and screws based on the principles described by Luhr [48, 49]. If a graft has been used, an extra microplate is additionally applied to stabilize each interpositional cortico-cancellous (iliac) graft. For repairing facial asymmetries and secondary deformities, mandibular and jaw osteotomies are also frequently required in UCLP patients in addition to Le Fort I osteotomy.
\n
\n
\n
\n
\n
6. Orthognathic approach on BCLP deformities
\n
\n
6.1 Prevalence
\n
In the study that was carried out at Boston Pediatrics Hospital, it was stated that there was a need for maxillary advancement by orthognathic surgery in 76.5% adolescents whose BCLP had been repaired [3]. Moreover, the authors explained that, in addition to the severity of the cleft type, the number of previous operations and extent of cleft area also affect the need for orthognathic surgery. Another study conducted at Toronto Pediatrics Hospital stated that there was a need for orthognathic surgery in 65.1% of their own BCLP patients, while this rate was 70% for patients who were referred by other centers [8]. From the Cleft Craniofacial Unit in Adelaide, Australia, David et al. [50] followed BCLP patient groups from birth to adulthood and determined the need for orthognathic surgery. Accordingly, orthognathic repair was needed in skeletal class III malocclusion among 17 of 19 patients (89.5%) and when they reached 18 years of age. Other previous studies also supported the findings of the aforementioned ones [51, 52].
\n
\n
\n
6.2 Orthodontic approach
\n
Different degrees of dysplasia in the sagittal, vertical, and horizontal directions are observed on the maxilla of patients without an ideal bone graft in the mixed dentition period that is divided into three segments. Before surgical treatment of maxillary segments, each segment is separately treated by an orthodontist. Before orthodontic treatment, cephalometric and panoramic radiography images are taken, and the angles, positions, and morphologies of teeth to soft tissues and bones are examined. In these patients, the volumes of the bones in the cleft region and the detailed position of teeth may be analyzed by additionally taking cone beam computerized tomography (CBCT) images.
\n
BCLP patients have a broad variation in terms of the amount of dentoalveolar bone and the number of permanent teeth. Teeth that resemble lateral incisors are usually observed along the sides of the lateral segments. Due to the usually underdeveloped root structure of these teeth and their deformed crowns, extracting them is reasonable. Because of the deformed crowns and root structures of also the erupted supernumerary teeth found in the premaxilla of BCLP patients, it is usually appropriate to extract these during orthodontic treatment. In addition to this, only 7% of BCLP patients have lateral teeth with regular structure [6], and these are kept in the arch and moved to ideal position by the orthodontist.
\n
Decision to extract the premolar teeth is dependent on the width and height of the present alveolar bone, position of canines, and the degree of crowding on the segments. In cases where inadequate bone and periodontal support remains or this support is substantially weakened after leveling and aligning the canines adjacent to the cleft, decision to extract of premolar teeth may be taken by the orthodontist. Aligning and leveling of the second molar teeth in addition to other maxillary teeth will increase the success of orthognathic surgery by improving the arch form and occlusion [35]. While extractions in the mandibular arch may be required based on the need for space on the arch and during the process of moving the incisors to an ideal angle, extraction is usually not necessary on the mandibular arch.
\n
\n
\n
6.3 Surgical approach
\n
Incomplete, insufficient definitions were presented by previous studies for surgical techniques used for the purpose of warning BCLP patients about possible complications regarding maxillary osteotomy and achieving reliable osteotomy operations [39, 53]. Hugo Obwegeser provided significant contributions which may be considered as milestones about cleft surgery on BCLP patients. However, at the early stages, very few clinicians adopted the methods of Obwegeser. This was because, as one of the eight patients he treated died of airway complications, and the results on the others were not reported in an appropriate manner, relevant studies criticized them [54]. In the mid-1980s, Posnick described a safe method of the segmental Le Fort I osteotomy technique that considers biological principles in BCLP patients with maxillomandibular deformities [17, 55, 56]. This method, for instance, emphasizes preservation of the labial soft tissue mucosal pedicle in the maxillary of patients. The significance of this flap circulation that is achieved by considering biological principles was confirmed in the study by Bell et al. that was carried out on Rhesus monkeys [38].
\n
Mainly, in BCLP patients, clinicians encounter maxillary deformities including those that are intact on both sides (successfully grafted) with one alveolar ridge, those with two segments with one side intact (successfully grafted), and those with three segments that are failed/non-grafted, and they apply different orthognathic surgery methods for these.
\n
\n
6.3.1 Standard Le fort I osteotomy
\n
Patients in cases of BCLP may have intact alveolar ridges on both sides, one intact alveolar ridge on only one side or alveolar clefts that have been successfully grafted during mixed dentition. In adolescents or adults with maxillomandibular deformity and intact alveolar ridges on both sides, a standard Le Fort I down-fracturing technique performs to advance maxillary hypoplasia.
\n
\n
\n
6.3.2 Modified Le fort I osteotomy (two-segment)
\n
In an individual with BCLP, a unilaterally intact alveolar ridge (with residual alveolar cleft and oronasal fistula on the other side) shows the same anatomy as those in a UCLP patient. The surgical approach for such a patient is the same as that which is applied for a UCLP patient with separated segments. For patients who are born with BCLP and non-grafted alveolar arches, the modified Le Fort I Osteotomy (three-segment) procedure should be applied.
\n
\n
\n
6.3.3 Modified Le fort I osteotomy (three-segment)
\n
Unfortunately, a big part of patients who have BCLP maxillomandibular deformities are still observed to have alveolar clefts, residual oronasal fistulae, and mobile premaxilla. While carrying out a Le Fort I osteotomy procedure on a BCLP patient with non-grafted alveolar arches, accurate incisions has a critical importance for providing all three segments with blood circulation [17].
\n
In the technique, on each side, a buccal (labiolateral) incision is made from the zygomatic buttresses (anterior and gingival levels of the parotid canal) in the depth of the vestibule extending toward the location of the residual oronasal fistula. Then, vertical incision continues according to mesial angle of the canine (or if the canine is missing, the most mesial tooth on each lateral segment). Without completely separating the premaxilla, an intermediate splint is placed to fix the lateral segments. The premaxilla is to be included to the vestibular incisions at the posterior with angular, vertical incisions in its labial direction, and to separate the oral and nasal mucosa of the fistulae even further, the incision continues downward along the distal line angle of the central incisor teeth on both sides. Attention should be paid to prevent deformation or incision of the mucosa in the premaxilla. Shavings are made from the segments to get the hard and soft tissues closer to each other. While doing this, one should be careful not to damage the lamina dura of the existing teeth. After completion of the premaxillary segment and other adjustments, the final splint is placed, and the segments are fixed with titanium plates and screws [17]. If there is grafting, an additional microplate is also needed to stabilize each cortico-cancellous (iliac) graft. To repair facial asymmetries, mandibular deformations, and secondary deformities, mandibular surgery may also be needed in addition to Le Fort I osteotomy in BCLP patients.
\n
\n
\n
\n
\n
7. Orthognathic approach on ICP deformities
\n
\n
7.1 Prevalence
\n
It was reported that 20% of Caucasians with ICP who receive repairs in the period of infancy would experience maxillary hypoplasia in a way that would lead to malocclusions that do not respond to a conventional or compensatory orthodontic approach by itself [36]. Chen et al. [57] reported on the horizontal maxillary growth of both children and adults with ethnic origins of Eastern China who were operated/not operated. Accordingly, as an interesting finding, the results of the individuals with ICP who were not operated in the mixed dentition period showed an almost normal horizontal growth. In the patients who were operated (repaired cleft palate) in the mixed dentition period, there was a decrease in the clockwise rotation of the maxillomandibular complex. In addition to this, it was stated that, for an individual born with ICP, the prevalence of maxillomandibular deficiency is dependent on a combination of factors such as the internal structure of the primary cleft defect, secondary hypoplasia due to surgical repair at infancy, and functional factors (e.g., muscle effects – mastication, respiratory pattern, and mandibular resting posture) [58].
\n
\n
\n
7.2 Orthodontic approach
\n
The main purpose of orthodontic treatment before surgery in ICP patients is to eliminate all existing dental compensations. This is because, conducting camouflage treatment in these patients threatens periodontal health and may cause to relapse and resorption in teeth. Inclination and angulation of the maxillary and mandibular teeth, crowding, gaps, and rotations are organized throughout the orthodontic treatment process. The targets related to achieving ideal arch forms and ideal occlusion may be detailed after the operation. Extractions may be needed in the maxillary arch to eliminate dental compensations. In comparison to UCLP or BCLP patients, treatment is simpler in ICP patients due to the intact nature of the alveolar bone and because all teeth are usually present.
\n
\n
\n
7.3 Surgical approach
\n
In general, primary maxillomandibular deformity that is seen in ICP patients is maxillary hypoplasia that is caused by the cleft deformity and surgical interventions. The normal reconstructive procedure that needs to be considered in these patients is a Le Fort I maxillary osteotomy. Obwegeser stated that complete mobilization of maxilla that are down fractured is needed to achieve an orthognathic repair during surgery and decrease skeletal relapse [35]. Bell and Levy [45] confirmed that the Obwegeser Le Fort I technique allows sufficient blood diffusion for satisfactory bone recovery without aseptic necrosis or tooth injury.
\n
It would be difficult to close any residual palatal oronasal fistula in an ICP patient at the same time with the Le Fort I procedure during orthognathic surgery. The reason for this is that elevation of the palatal flaps that is usually needed will threaten the blood supply for the down-fractured maxilla. Moreover, it was stated that, if an impermeable closure of the nasal side can be achieved following down-fracturing before fixing the maxilla to its new position, the residual mucosal gap on the palatal side will usually be recovered secondarily by fistula closure [35].
\n
\n
\n
\n
8. Post-surgery clinical management
\n
Management of the process at the hospital and at home during the initial recovery process of the orthognathic patient is highly important for a successful outcome. Cephalometric and dental radiographies and facial and occlusal photographs should be taken at certain intervals after the surgery in order to documentation and check the patient’s recovery [17].
\n
Orthodontist should remove the splint and see the patient in the next 24 hours to replace the maxillary segmental arch wires or rigid continuous arch wires. The maxillary teeth are tied to each other to preserve the occlusion, sagittal advancement, and transversal dimension. After 2 months of surgery, active orthodontic treatment and finishing procedures can be continued. A trans-palatal appliance (wire or palatal appliance) is recommended to stabilize the new arch form. The orthodontist should closely monitor the patients throughout the 6 months following the surgery to follow up on skeletal and dental relapse and to maintain orthodontic treatment [17].
\n
In routine and unproblematic cases, splint usage is abandoned in about 5–7 after the surgery. However, in patients with early skeletal relapse, that is, within the first 2–8 weeks, the teeth are forced in the buccolingual direction toward outside of the bone because the teeth are held in place due to splint despite the alveolar relapse, and severe gingival recessions may occur (\nFigure 3\n). Therefore, CLP patients should be observed every week, unlike other orthognathic surgical patients. It should be kept in mind that the relapse rates given in the literature are averages, and it is possible to see more of these amounts in individual cases.
\n
Figure 3.
Periodontal tissue loss due to relapse [25]. (a) Initial: Patient with UCLP, maxillary hypoplasia, severe crowding, missing lateral, and asymmetric arch form. (b) Pre-op: Periodontal problems after expansion and leveling. (c) Post-op: Both transverse and sagittal skeletal relapse occur while teeth are locked within the arch-wire and surgical splint, which deteriorates the periodontal condition. The midline was surgically corrected.
\n
Speech may be objectively assessed in 3–6 months after the surgery. A nasal endoscopy may be used for this. Exact cleft-soft tissue procedures (e.g., cleft rhinoplasty, revision of the labial scar, pharyngeal flap or flap revision) may be carried out in 6 months after the operation. After removal of orthodontic appliances, pre-planned restorative approaches may be implemented [17].
\n
\n
\n
9. Success of orthognathic surgery
\n
After orthognathic surgery, cleft patients have a higher than normal risk of relapse due to factors such as different soft tissue-bone relations and complex mobilization vectors. Fahradyan et al. [59] reported that, in comparison to class III malocclusion patients without clefts, more relapse was encountered in those with clefts (1.25 mm or more on average), and there was a significant positive correlation between larger clefts and horizontal relapse. In their study, the mean relapse rate was similar among different types of clefts, and in the case of each 1 mm increase in maxillary advancement, horizontal relapse increased by 0.3 mm on average [59].
\n
Richardson et al. [60] examined all relapse cases among individuals where more than 11 mm of maxillary advancement was applied, and they reported a horizontal relapse rate of 18.75%. Nevertheless, Bhatia et al. [61] concluded that relapse rates stayed the same even in maxillary advancement degrees of more than 15 mm (mostly in cleft patients). Yamaguchi et al. [62] reported in their systematic review that the mean values of horizontal and vertical relapse were, respectively, 17.9% and 35.4% in orthodontic surgery for cleft patients. This shows us that vertical stability is lower.
\n
Although most studies focused on horizontal maxillary stability, Park et al. [63] reported that postoperative mandibular relapse in cleft patients had a strong positive correlation with mandibular clockwise rotation and setback amounts. Wong et al. [64] could not find a significant difference between the relapse rates of individuals who received two surgical operations and those who received maxillary advancement surgery only. Some researchers used bone grafts to increase horizontal or vertical stability [61, 63, 64]. It was reported that usage of grafts has a preventive effect on horizontal maxillary stability with an average of 1.72 mm less relapse [61].
\n
\n
\n
10. Complications
\n
\n
10.1 Airway problems
\n
Treatment of cleft patients with class III malocclusion that results out of the combination of maxillary hypoplasia and intermaxillary disorder is usually achieved by maxillary advancement, mandibular setback, and clockwise rotation of the maxillomandibular complex. While maxillary advancement is associated with increased upper airway cavity, in contrast, mandibular setback is associated with reduction of airways with outcomes such as postoperative airway blockage, snoring, hypopnea (slow respiration), and obstructive sleep apnoea [65, 66]. Additionally, a pharyngeal flap may contribute to the airway-related difficulties that are encountered during operation or in the postoperative period. When the three-dimensional (3D) pharyngeal airway cavity of cleft patients in their pre- or post-pubertal periods were compared to a control group, Karia et al. [66] found significantly smaller airway sizes in the cleft group. The total airway volume increased from the pre-pubertal to the post-pubertal periods in both groups, but the reason for this outcome in the cleft group was not anteroposterior growth as in the case of the control group, but in contrast, associated with vertical airway growth. Especially in bilateral cleft patients, significantly reduced pharyngeal airway cavity in comparison to individuals without clefts was also confirmed in a CBCT study [67].
\n
A prospective study by Chang et al. [68] examined the airway changes in cleft patients who received maxillary advancement and mandibular setback treatments by not only CBCT but also polysomnographic examination. Regarding the airway changes after orthognathic surgery, it was found that there was no significant difference in sleep-related respiratory functions, but the snoring index was improved.
\n
\n
\n
10.2 Speech impediment
\n
It is believed that maxillary advancement in cleft patients has a potential to worsen velopharyngeal function (VPF). Nevertheless, there is still no certain evidence on whether or not the amount of advancement affects velopharyngeal disorder and whether or not preoperative VPF is related to the postoperative outcome. It is most likely that improvements are seen in the articulation of patients after surgery due to the correction of dental arches [69]. In a systematic review of the complications that developed as a result of orthognathic surgery on cleft patients, Yamaguchi et al. [62] reported postoperative velopharyngeal deficiency (VPD) as 16.79%.
\n
Moran et al. [70] examined 79 cleft patients who received treatments of conventional orthognathic surgery or distraction osteogenesis, and they reported that, following maxillary advancement rates from 3 to 11 mm, there was VPD in 5 (6.33%) cases. These five patients were also found to have borderline VPD preoperatively. The results of their study supported those of other studies that there is no relationship between maxillary advancement and the amount of postoperative velopharyngeal disorders [71], and when orthognathic surgery and total maxillary distraction are compared in terms of speech and VPD, there is no significant difference [71, 72, 73]. Additionally, the finding that there is no correlation between postoperative speech impediment and preoperative borderline VPD was added to the literature which reported similar findings [71, 72, 73].
\n
It is a difficult process to estimate soft tissue changes after orthognathic surgery and prevent them. This is because the adaptation of the velopharyngeal region for compensation of other regions is variable, and it is dependent on the personal characteristics of each patient and the capacity of tissues that are present or transplanted to become functional [74].
\n
\n
\n
10.3 Infection
\n
Infection rates following orthognathic surgery are highly variable due to reasons such as antibiotics usage styles and diagnostic differences [75, 76]. Recent studies on orthognathic surgery in individuals without clefts reported an incidence of less than 1–8% [76, 77, 78].
\n
Miloro derived a few results by analyzing 15 previous studies on infections following orthognathic surgery: infection incidence may decrease in the case of using oral antibiotics for more than 1 day after surgery. First-generation cephalosporins are used more frequently before surgery. Mandibular osteotomy regions are where infections are seen the most. Extraction of the third molar may have a small effect on infection incidence, but this is under debate. Most infections that occur after orthognathic surgery are small, and removal of fixation plates and screws is rarely necessary [75].
\n
In an analysis of the USA National Inpatient Samples Database (2012–2013), the rate of emergence for any kind of infectious complication following orthognathic surgery was reported as 7.4% in patients with a craniofacial anomaly and 0.6% in those without a craniofacial anomaly [78]. Recent studies reported rates of from 0to 13.92% for infections emerging after orthognathic surgery in cleft patients without any craniofacial anomaly [61, 62, 68, 70]. In the study that obtained a high rate of incidence as 13.92% despite 5 days of routine antibiotics usage, the authors emphasized the importance of oral hygiene, team collaboration, and patient cooperation [70].
\n
\n
\n
10.4 Oronasal fistula
\n
Segmental maxillary osteotomies may have a risk of postoperative oronasal fistulae. In a systematic review in 2017, the postoperative fistula rate was reported as 19.3% in segmental Le Fort I osteotomy [79]. While residual oronasal fistulae in cleft patients increase the difficult of orthognathic surgery, they may be repaired by adjusting the incision patterns during surgery. In addition to this, according to the systematic review in 2016 by Yamaguchi et al. [62], the closure deficiency of a pre-existing fistulae (28.57% for palatal, 10.74% for alveolar fistulae) was the most frequently encountered complication. Another study reported a residual fistulae rate of 10.53% [70]. Nevertheless, residual fistulae rates may be reduced by careful dissection, unstressed closure, delicate tissue management, and compliance with blood circulation [80].
\n
\n
\n
10.5 Nerve damage
\n
The neural disorders that occur as a result of orthognathic surgery mainly affect the infraorbital, inferior alveolar (mandibular), and mental and incisive nerves. Reports on facial nerve paralysis vary in the range of 0.17–0.75% [81].
\n
The incidence of continuation of inferior alveolar nerve disorders varies between 5 and 15% depending on the age of the patient and the technique that is used (piezo-surgery or conventional) [82, 83]. A systematic review in 2017 reported that usage of piezo-surgery in orthognathic operations was associated with significant reductions of loss of blood during surgery and severe nervous disorders [84].
\n
In orthognathic surgery on cleft patients, 70% of the patients may experience paresthesia after surgery, and a permanent sensory disorder may occur in 25% [80]. Bhatia et al. [61] stated that all 25% of patients who experienced cheek paresthesia recovered after a year. Moran et al. [70] reported that the sensory neuropathy of the infraorbital nerve was temporary in 53% of patients and permanent in 1.27%. In addition to this, 3D computer-assisted planning and determination of the inferior alveolar nerve may contribute to the safety of orthognathic surgery [85].
\n
\n
\n
\n
11. Conclusion
\n
Orthognathic surgery, which is the last stage of CLP treatment, is a highly important step in management of the entire process. Therefore, there should be good communication among the patient, the family, and the cleft team. There are effects of factors that are unique to individuals or clefts on the outcomes of surgery, but their extent is still under debate.
\n
Despite the different rates reported in the literature, the rates of complications in cleft surgery are striking. Strategies should be created by focusing on causes and mechanisms to prevent or minimize these complications.
\n
\n\n',keywords:"orthognathic surgery, cleft lip and palate, complications",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/69846.pdf",chapterXML:"https://mts.intechopen.com/source/xml/69846.xml",downloadPdfUrl:"/chapter/pdf-download/69846",previewPdfUrl:"/chapter/pdf-preview/69846",totalDownloads:920,totalViews:0,totalCrossrefCites:1,totalDimensionsCites:1,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:67,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"May 24th 2019",dateReviewed:"September 5th 2019",datePrePublished:"November 26th 2019",datePublished:"March 25th 2020",dateFinished:"October 31st 2019",readingETA:"0",abstract:"Cleft lip and palate patients often exhibit severe dentofacial deformities that necessitate orthognathic surgery. Orthognathic surgery in these patients generally includes not only maxillary advancement, but also sagittal, horizontal, and vertical movement of both jaws. Surgical planning and execution presents many difficulties, caused by the presence of extensive scar tissues from previous surgeries, tissue deficiencies, the difficulty of aligning multiple segments of bone and soft tissues. Other challenges in cleft patients are complications related to post-surgical airway, speech, velopharyngeal insufficiency, nerve damage, and infections. This review is focused on orthognathic surgery in cleft lip and palate patients, management, techniques, success, and complications.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/69846",risUrl:"/chapter/ris/69846",book:{id:"7973",slug:"current-treatment-of-cleft-lip-and-palate"},signatures:"Hakan Yilmaz and Arzu Ari Demirkaya",authors:[{id:"306192",title:"M.Sc.",name:"Hakan",middleName:null,surname:"Yilmaz",fullName:"Hakan Yilmaz",slug:"hakan-yilmaz",email:"hakanyilmaz90@gmail.com",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/306192/images/8628_n.jpg",institution:{name:"Bülent Ecevit University",institutionURL:null,country:{name:"Turkey"}}},{id:"306194",title:"Prof.",name:"Arzu",middleName:null,surname:"Ari Demirkaya",fullName:"Arzu Ari Demirkaya",slug:"arzu-ari-demirkaya",email:"aaridem@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Okan University",institutionURL:null,country:{name:"Turkey"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Timing of orthognathic surgery",level:"1"},{id:"sec_3",title:"3. Preparation for orthognathic surgery",level:"1"},{id:"sec_4",title:"4. Residual deformities in CLP patients",level:"1"},{id:"sec_5",title:"5. Orthognathic approach on UCLP deformities",level:"1"},{id:"sec_5_2",title:"5.1 Prevalence",level:"2"},{id:"sec_6_2",title:"5.2 Orthodontic approach",level:"2"},{id:"sec_7_2",title:"5.3 Surgical approach",level:"2"},{id:"sec_7_3",title:"5.3.1 Standard Le fort I osteotomy",level:"3"},{id:"sec_8_3",title:"5.3.2 Modified Le fort I osteotomy (two-segment)",level:"3"},{id:"sec_11",title:"6. Orthognathic approach on BCLP deformities",level:"1"},{id:"sec_11_2",title:"6.1 Prevalence",level:"2"},{id:"sec_12_2",title:"6.2 Orthodontic approach",level:"2"},{id:"sec_13_2",title:"6.3 Surgical approach",level:"2"},{id:"sec_13_3",title:"6.3.1 Standard Le fort I osteotomy",level:"3"},{id:"sec_14_3",title:"6.3.2 Modified Le fort I osteotomy (two-segment)",level:"3"},{id:"sec_15_3",title:"6.3.3 Modified Le fort I osteotomy (three-segment)",level:"3"},{id:"sec_18",title:"7. Orthognathic approach on ICP deformities",level:"1"},{id:"sec_18_2",title:"7.1 Prevalence",level:"2"},{id:"sec_19_2",title:"7.2 Orthodontic approach",level:"2"},{id:"sec_20_2",title:"7.3 Surgical approach",level:"2"},{id:"sec_22",title:"8. Post-surgery clinical management",level:"1"},{id:"sec_23",title:"9. Success of orthognathic surgery",level:"1"},{id:"sec_24",title:"10. Complications",level:"1"},{id:"sec_24_2",title:"10.1 Airway problems",level:"2"},{id:"sec_25_2",title:"10.2 Speech impediment",level:"2"},{id:"sec_26_2",title:"10.3 Infection",level:"2"},{id:"sec_27_2",title:"10.4 Oronasal fistula",level:"2"},{id:"sec_28_2",title:"10.5 Nerve damage",level:"2"},{id:"sec_30",title:"11. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'\nBroome M, Herzog G, Hohlfeld J, de Buys Roessingh A, Jaques B. Influence of the primary cleft palate closure on the future need for orthognathic surgery in unilateral cleft lip and palate patients. The Journal of Craniofacial Surgery. 2010;21(5):1615-1618\n'},{id:"B2",body:'\nRosenstein SW, Grasseschi M, Dado DV. A long-term retrospective outcome assessment of facial growth, secondary surgical need, and maxillary lateral incisor status in a surgical-orthodontic protocol for complete clefts. Plastic and Reconstructive Surgery. 2003;111(1):1-13; discussion 4-6\n'},{id:"B3",body:'\nGood PM, Mulliken JB, Padwa BL. Frequency of Le fort I osteotomy after repaired cleft lip and palate or cleft palate. The Cleft Palate-Craniofacial Journal. 2007;44(4):396-401\n'},{id:"B4",body:'\nFilho LC, Normando ADC, Da Silva Filho OG. Isolated influences of lip and palate surgery on facial growth: Comparison of operated and unoperated male adults with UCLP. The Cleft Palate-Craniofacial Journal. 1996;33(1):51-56\n'},{id:"B5",body:'\nAstani SA, Yilmaz HN, Nevzatoglu S, Demirkaya AA, Acar ZA. Evaluation of airway volume in cleft lip and palate following nasoalveolar molding. The Journal of Craniofacial Surgery. 2018;29(8):2143-2147\n'},{id:"B6",body:'\nCassolato SF, Ross B, Daskalogiannakis J, Noble J, Tompson B. Treatment of dental anomalies in children with complete unilateral cleft lip and palate at SickKids hospital, Toronto. The Cleft Palate-Craniofacial Journal. 2009;46(2):166-172\n'},{id:"B7",body:'\nMcCance AM, Roberts-Harry D, Sherriff M, Mars M, Houston WJ. A study model analysis of adult unoperated Sri Lankans with unilateral cleft lip and palate. The Cleft Palate Journal. 1990;27(2):146-154\n'},{id:"B8",body:'\nDaskalogiannakis J, Mehta M. The need for orthognathic surgery in patients with repaired complete unilateral and complete bilateral cleft lip and palate. The Cleft Palate-Craniofacial Journal. 2009;46(5):498-502\n'},{id:"B9",body:'\nSwennen G, Colle F, De AM, Malevez C. Maxillary distraction in cleft lip palate patients: A review of six cases. The Journal of Craniofacial Surgery. 1999;10(2):117-122\n'},{id:"B10",body:'\nWolford LM. Effects of orthognathic surgery on nasal form and function in the cleft patient. The Cleft Palate-Craniofacial Journal. 1992;29(6):546-555\n'},{id:"B11",body:'\nKuo-Ting Chen P, Por Y-C, Jein-Wein Liou E, Chun-Shin Chang F. Maxillary distraction osteogenesis in the adolescent cleft patient: Three-dimensional computed tomography analysis of linear and volumetric changes over five years. The Cleft Palate-Craniofacial Journal. 2011;48(4):445-454\n'},{id:"B12",body:'\nFigueroa AA, Polley JW, Ko EW-C. Maxillary distraction for the management of cleft maxillary hypoplasia with a rigid external distraction system. Seminars in Orthodontics. 1999;5(1):46-51\n'},{id:"B13",body:'\nPosnick JC, Tiwana PS. Cleft-Orthognathic Surgery. In: Berkowitz S, editor. Cleft Lip and Palate. Heidelberg, Berlin: Springer; 2006. pp. 573-585\n'},{id:"B14",body:'\nHarper DC. Children\'s attitudes to physical differences among youth from Western and non-Western cultures. The Cleft Palate-Craniofacial Journal. 1995;32(2):114-119\n'},{id:"B15",body:'\nJorgenson R, Shapiro S, Odinet K. Studies on facial growth and arch size in cleft lip and palate. Journal of Craniofacial Genetics and Developmental Biology. 1984;4(1):33-38\n'},{id:"B16",body:'\nMccance AM, Moss JP, Fright WR, Linney AD, James DR. Three-dimensional analysis techniques—Part 1: Three-dimensional soft-tissue analysis of 24 adult cleft palate patients following Le fort I maxillary advancement: A preliminary report. The Cleft Palate-Craniofacial Journal. 1997;34(1):36-45\n'},{id:"B17",body:'\nPosnick JC. Principles and Practice of Orthognathic Surgery. London, United Kingdom: Elsevier Health Sciences; 2013\n'},{id:"B18",body:'\nSiegel-Sadewitz V, Shprintzen R. Nasopharyngoscopy of the normal velopharyngeal sphincter: An experiment of biofeedback. The Cleft Palate Journal. 1982;19(3):194-200\n'},{id:"B19",body:'\nVallino LD, Tompson B. Perceptual characteristics of consonant errors associated with malocclusion. Journal of Oral and Maxillofacial Surgery. 1993;51(8):850-856\n'},{id:"B20",body:'\nProffit W, editor. Orthodontic Treatment of Clefts: Yesterday, Today, and Tomorrow. Proceedings of the 48th Annual Meeting. American Cleft Palate-Craniofacial Association Hilton Head; 1991\n'},{id:"B21",body:'\nWarren DW. Perceptual characteristics of consonant errors associated with malocclusion. Journal of Oral and Maxillofacial Surgery. 1993;51(8):856\n'},{id:"B22",body:'\nSandham A, Murray J. Nasal septal deformity in unilateral cleft lip and palate. The Cleft Palate-Craniofacial Journal. 1993;30(2):222-226\n'},{id:"B23",body:'\nKolbenstvedt A, Aaløkken T, Arctander K, Johannessen S. CT appearances of unilateral cleft palate 20 years after bone graft surgery. Acta Radiologica. 2002;43(6):567-570\n'},{id:"B24",body:'\nTrindade IE, Yamashita RP, Suguimoto RM, Mazzottini R, Trindade AS Jr. Effects of orthognathic surgery on speech and breathing of subjects with cleft lip and palate: Acoustic and aerodynamic assessment. The Cleft Palate-Craniofacial Journal. 2003;40(1):54-64\n'},{id:"B25",body:'\nYilmaz H, Demirkaya AA. Dudak damak yariğinda ortognatik cerrahi. Turkiye Klinikleri Orthodontics-Special Topics. 2019;5(1):34-41\n'},{id:"B26",body:'\nStoelinga PJ, Leenen RJ, Blijdorp PA, Schoenaers JH, Team CP. The prevention of relapse after maxillary osteotomies in cleft palate patients. Journal of Cranio-Maxillofacial Surgery. 1987;15:326-331\n'},{id:"B27",body:'\nPosnick JC. The treatment of secondary and residual dentofacial deformities in the cleft patient. Surgical and orthodontic therapy. Clinics in Plastic Surgery. 1997;24(3):583-597\n'},{id:"B28",body:'\nRobertsson S, Mohlin B. The congenitally missing upper lateral incisor. A retrospective study of orthodontic space closure versus restorative treatment. The European Journal of Orthodontics. 2000;22(6):697-710\n'},{id:"B29",body:'\nSuzuki A, Takahama Y. Maxillary lateral incisor of subjects with cleft lip and/or palate: Part 1. The Cleft Palate-Craniofacial Journal. 1992;29(4):376-379\n'},{id:"B30",body:'\nSuzuki A, Watanabe M, Nakano M, Takahama Y. Maxillary lateral incisors of subjects with cleft lip and/or palate: Part 2. The Cleft Palate-Craniofacial Journal. 1992;29(4):380-384\n'},{id:"B31",body:'\nLaspos CP, Kyrkanides S, Tallents RH, Moss ME, Subtelny JD. Mandibular and maxillary asymmetry in individuals with unilateral cleft lip and palate. The Cleft Palate-Craniofacial Journal. 1997;34(3):232-239\n'},{id:"B32",body:'\nNordquist GG, McNeill RW. Orthodontic vs. restorative treatment of the congenitally absent lateral incisor—Long term periodontal and occlusal evaluation. Journal of Periodontology. 1975;46(3):139-143\n'},{id:"B33",body:'\nFelstead AM, Deacon S, Orth M, Revington PJ. The outcome for secondary alveolar bone grafting in the south West UK region post-CSAG. The Cleft Palate-Craniofacial Journal. 2010;47(4):359-362\n'},{id:"B34",body:'\nMcIntyre GT, Devlin MF. Secondary alveolar bone grafting (CLEFTSiS) 2000-2004. The Cleft Palate-Craniofacial Journal. 2010;47(1):66-72\n'},{id:"B35",body:'\nPosnick JC. Cleft Jaw Deformities and their Management. Cleft Lip and Palate. Heidelberg, Berlin: Springer; 2013. pp. 557-599\n'},{id:"B36",body:'\nÅbyholm FE, Bergland O, Semb G. Secondary bone grafting of alveolar clefts: A surgical/orthodontic treatment enabling a non-prosthodontic rehabilitation in cleft lip and palate patients. Scandinavian Journal of Plastic and Reconstructive Surgery. 1981;15(2):127-140\n'},{id:"B37",body:'\nRoss RB. Treatment variables affecting facial growth in complete unilateral cleft lip and palate. Part 7: An overview of treatment and facial growth. The Cleft Palate Journal. 1987;24:71-77\n'},{id:"B38",body:'\nBell WH, You ZH, Finn RA, Fields RT. Wound healing after multisegmental Le fort I osteotomy and transection of the descending palatine vessels. Journal of Oral and Maxillofacial Surgery. 1995;53(12):1425-1433\n'},{id:"B39",body:'\nFitzpatrick B. Mid-face osteotomy in the adolescent cleft palate patient. Australian Dental Journal. 1977;22(5):338-350\n'},{id:"B40",body:'\nJames DR, Brook K. Maxillary hypoplasia in patients with cleft lip and palate deformity—The alternative surgical approach. The European Journal of Orthodontics. 1985;7(4):231-247\n'},{id:"B41",body:'\nWestbrook MT Jr, West RA, McNeill RW. Simultaneous maxillary advancement and closure of bilateral alveolar clefts and oronasal fistulas. Journal of Oral and Maxillofacial Surgery. 1983;41(4):257-260\n'},{id:"B42",body:'\nDrommer RB. The history of the “Le fort I osteotomy”. Journal of Maxillofacial Surgery. 1986;14:119-122\n'},{id:"B43",body:'\nObwegeser H, editor. Surgical Correction of Deformities of the Jaws in Adult Cleft Cases. First International Conference on Cleft Lip and Palate. Houston; 1969\n'},{id:"B44",body:'\nObwegeser HL, editor Surgery as an Adjunct Ot Orthodontics in Normal and Cleft Palate Patients. Report of the Congress European Orthodontic Society; 1966\n'},{id:"B45",body:'\nBell W, Levy B. Revascularization and bone healing after posterior maxillary osteotomy. Journal of Oral Surgery. 1971;29(5):313-320\n'},{id:"B46",body:'\nPosnick JC, Tompson B. Modification of the maxillary Le fort I osteotomy in cleft-orthognathic surgery: The unilateral cleft lip and palate deformity. Journal of Oral and Maxillofacial Surgery. 1992;50(7):666-675\n'},{id:"B47",body:'\nObwegeser HL. Orthognathic surgery and a tale of how three procedures came to be: A letter to the next generations of surgeons. Clinics in Plastic Surgery. 2007;34(3):331-355\n'},{id:"B48",body:'\nChampy M. Surgical treatment of midface deformities. Head & Neck Surgery. 1980;2(6):451-465\n'},{id:"B49",body:'\nLund TW, Wade M. Use of osseointegrated implants to support a maxillary denture for a patient with repaired cleft lip and palate. The Cleft Palate-Craniofacial Journal. 1993;30(4):418-420\n'},{id:"B50",body:'\nDavid DJ, Anderson PJ, Schnitt DE, Nugent MA, Sells R. From birth to maturity: A group of patients who have completed their protocol management. Part II. Isolated cleft palate. Plastic and Reconstructive Surgery. 2006;117(2):515-526\n'},{id:"B51",body:'\nFriede H, Pruzansky S. Long-term effects of premaxillary setback on facial skeletal profile in complete bilateral cleft lip and palate. The Cleft Palate Journal. 1985;22(2):97-105\n'},{id:"B52",body:'\nLisson JA, Tränkmann J. Comparative survey of osteotomized and nonosteotomized BCLP patients. The Cleft Palate-Craniofacial Journal. 1997;34(5):430-437\n'},{id:"B53",body:'\nPoole MD, Robinson PP, Nunn ME. Maxillary advancement in cleft palate patients: A modification of the Le fort I osteotomy and preliminary results. Journal of Maxillofacial Surgery. 1986;14:123-127\n'},{id:"B54",body:'\nWillmar K. On Le fort I osteotomy; a follow-up study of 106 operated patients with maxillo-facial deformity. Scandinavian Journal of Plastic and Reconstructive Surgery. 1974;12(suppl 12):1\n'},{id:"B55",body:'\nPosnick JC. Orthognathic surgery for the cleft lip and palate patient. Seminars in Orthodontics. 1996;2(3):205-214\n'},{id:"B56",body:'\nPosnick JC, Tompson B. Modification of the maxillary Le fort I osteotomy in cleft-orthognathic surgery: The bilateral cleft lip and palate deformity. Journal of Oral and Maxillofacial Surgery. 1993;51(1):2-11\n'},{id:"B57",body:'\nChen Z-Q , Qian Y-F, Wang G-M, Shen G. Sagittal maxillary growth in patients with unoperated isolated cleft palate. The Cleft Palate-Craniofacial Journal. 2009;46(6):664-667\n'},{id:"B58",body:'\nCanady JW, Thompson SA, Colburn A. Craniofacial growth after latrogenic cleft palate repair in a fetal ovine model. The Cleft Palate-Craniofacial Journal. 1997;34(1):69-72\n'},{id:"B59",body:'\nFahradyan A, Wolfswinkel EM, Clarke N, Park S, Tsuha M, Urata MM, et al. Impact of the distance of maxillary advancement on horizontal relapse after orthognathic surgery. The Cleft Palate-Craniofacial Journal. 2018;55(4):546-553\n'},{id:"B60",body:'\nRichardson S, Krishna S, Khandeparker RV. A comprehensive management protocol to treat cleft maxillary hypoplasia. Journal of Cranio-Maxillofacial Surgery. 2018;46(2):356-361\n'},{id:"B61",body:'\nBhatia S, Bocca A, Jones J, Sugar AW. Le fort I advancement osteotomies of 1 cm or more. How safe or stable? The British Journal of Oral & Maxillofacial Surgery. 2016;54(3):346-350\n'},{id:"B62",body:'\nYamaguchi K, Lonic D, Lo L-J. Complications following orthognathic surgery for patients with cleft lip/palate: A systematic review. Journal of the Formosan Medical Association. 2016;115(4):269-277\n'},{id:"B63",body:'\nPark Y-H, Seo J-H, Yang I-H, Choi J-Y, Lee J-H, Kim M-J, et al. What are the contributing factors for postsurgical relapse after two-jaw surgery in patients with cleft lip and palate. The Journal of Craniofacial Surgery. 2017;28(4):1071-1077\n'},{id:"B64",body:'\nWong F, Heggie A, Shand J, Schneider P. Skeletal stability of maxillary advancement with and without a mandibular reduction in the cleft lip and palate patient. International Journal of Oral and Maxillofacial Surgery. 2016;45(12):1501-1507\n'},{id:"B65",body:'\nGerbino G, Gervasio FC, Blythe J, Bianchi FA. The management of iatrogenic obstructive sleep apnoea syndrome following bimaxillary surgery in a patient with cleft lip and palate. The Journal of Craniofacial Surgery. 2016;27(5):1286-1288\n'},{id:"B66",body:'\nKaria H, Shrivastav S, Karia AK. Three-dimensional evaluation of the airway spaces in patients with and without cleft lip and palate: A digital volume tomographic study. American Journal of Orthodontics and Dentofacial Orthopedics. 2017;152(3):371-381\n'},{id:"B67",body:'\nGandedkar NH, Chng CK, Basheer MA, Chen PY, Leng Yeow VK. Comparative evaluation of the pharyngeal airway space in unilateral and bilateral cleft lip and palate individuals with noncleft individuals: A cone beam computed tomography study. The Cleft Palate-Craniofacial Journal. 2017;54(5):509-516\n'},{id:"B68",body:'\nChang C-S, Wallace CG, Hsiao Y-C, Hsieh Y-J, Wang Y-C, Chen N-H, et al. Airway changes after cleft orthognathic surgery evaluated by three-dimensional computed tomography and overnight polysomnographic study. Scientific Reports. 2017;7(1):12260\n'},{id:"B69",body:'\nRichardson S, Seelan NS, Selvaraj D, Khandeparker RV, Gnanamony S. Perceptual speech assessment after anterior maxillary distraction in patients with cleft maxillary hypoplasia. Journal of Oral and Maxillofacial Surgery. 2016;74(6):1239. e1-e9\n'},{id:"B70",body:'\nMoran I, Virdee S, Sharp I, Sulh J. Postoperative complications following LeFort 1 maxillary advancement surgery in cleft palate patients: A 5-year retrospective study. The Cleft Palate-Craniofacial Journal. 2018;55(2):231-237\n'},{id:"B71",body:'\nChua H, Whitehill T, Samman N, Cheung L. Maxillary distraction versus orthognathic surgery in cleft lip and palate patients: Effects on speech and velopharyngeal function. International Journal of Oral and Maxillofacial Surgery. 2010;39(7):633-640\n'},{id:"B72",body:'\nMcComb RW, Marrinan EM, Nuss RC, LaBrie RA, Mulliken JB, Padwa BL. Predictors of velopharyngeal insufficiency after Le fort I maxillary advancement in patients with cleft palate. Journal of Oral and Maxillofacial Surgery. 2011;69(8):2226-2232\n'},{id:"B73",body:'\nPhillips JH, Klaiman P, Delorey R, MacDonald DB. Predictors of velopharyngeal insufficiency in cleft palate orthognathic surgery. Plastic and Reconstructive Surgery. 2005;115(3):681-686\n'},{id:"B74",body:'\nWu Y, Wang X, Ma L, Li Z. Velopharyngeal configuration changes following Le fort I osteotomy with maxillary advancement in patients with cleft lip and palate: A cephalometric study. The Cleft Palate-Craniofacial Journal. 2015;52(6):711-716\n'},{id:"B75",body:'\nMiloro M. Surgical site infections after orthognathic surgery. Journal of Oral and Maxillofacial Surgery. 2017;75(6):1101-1103\n'},{id:"B76",body:'\nPosnick JC, Choi E, Chavda A. Surgical site infections following bimaxillary orthognathic, osseous genioplasty, and intranasal surgery: A retrospective cohort study. Journal of Oral and Maxillofacial Surgery. 2017;75(3):584-595\n'},{id:"B77",body:'\nDavis CM, Gregoire CE, Steeves TW, Demsey A. Prevalence of surgical site infections following orthognathic surgery: A retrospective cohort analysis. Journal of Oral and Maxillofacial Surgery. 2016;74(6):1199-1206\n'},{id:"B78",body:'\nMetalwala Z, Okunseri C, Fletcher S, Allareddy V. Orthognathic surgical outcomes in patients with and without craniofacial anomalies. Journal of Oral and Maxillofacial Surgery. 2018;76(2):436. e1-e8\n'},{id:"B79",body:'\nJunior OH, Guijarro-Martínez R, de Sousa Gil A, da Silva Meirelles L, de Oliveira R, Hernandez-Alfaro F. Stability and surgical complications in segmental Le fort I osteotomy: A systematic review. International Journal of Oral and Maxillofacial Surgery. 2017;46(9):1071-1087\n'},{id:"B80",body:'\nOhrmann D, Hoyte-Williams PE, Chen PK-T. Update on complications in cleft orthognathic surgery. Current Opinion in Otolaryngology & Head and Neck Surgery. 2018;26(4):260-265\n'},{id:"B81",body:'\nKim Y-K. Complications associated with orthognathic surgery. Journal of the Korean Association of Oral and Maxillofacial Surgeons. 2017;43(1):3-15\n'},{id:"B82",body:'\nLandes CA, Stübinger S, Rieger J, Williger B, Ha TKL, Sader R. Critical evaluation of piezoelectric osteotomy in orthognathic surgery: Operative technique, blood loss, time requirement, nerve and vessel integrity. Journal of Oral and Maxillofacial Surgery. 2008;66(4):657-674\n'},{id:"B83",body:'\nVerweij J, Mensink G, Fiocco M, van Merkesteyn J. Incidence and recovery of neurosensory disturbances after bilateral sagittal split osteotomy in different age groups: A retrospective study of 263 patients. International Journal of Oral and Maxillofacial Surgery. 2016;45(7):898-903\n'},{id:"B84",body:'\nPagotto LEC, de Santana Santos T, de Vasconcellos SJA, Santos JS, Martins-Filho PRS. Piezoelectric versus conventional techniques for orthognathic surgery: Systematic review and meta-analysis. Journal of Cranio-Maxillofacial Surgery. 2017;45(10):1607-1613\n'},{id:"B85",body:'\nLonic D, Pai BC-J, Yamaguchi K, Chortrakarnkij P, Lin H-H, Lo L-J. Computer-assisted orthognathic surgery for patients with cleft lip/palate: From traditional planning to three-dimensional surgical simulation. PLoS One. 2016;11(3):e0152014\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Hakan Yilmaz",address:"hakanyilmaz90@gmail.com",affiliation:'
Department of Orthodontics, Faculty of Dentistry, Istanbul Okan University, Istanbul, Turkey
'},{corresp:null,contributorFullName:"Arzu Ari Demirkaya",address:null,affiliation:'
Department of Orthodontics, Faculty of Dentistry, Istanbul Okan University, Istanbul, Turkey
'}],corrections:null},book:{id:"7973",type:"book",title:"Current Treatment of Cleft Lip and Palate",subtitle:null,fullTitle:"Current Treatment of Cleft Lip and Palate",slug:"current-treatment-of-cleft-lip-and-palate",publishedDate:"March 25th 2020",bookSignature:"Ayşe Gülşen",coverURL:"https://cdn.intechopen.com/books/images_new/7973.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83880-014-7",printIsbn:"978-1-83880-013-0",pdfIsbn:"978-1-83880-480-0",reviewType:"peer-reviewed",numberOfWosCitations:0,isAvailableForWebshopOrdering:!0,editors:[{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1149"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"68449",type:"chapter",title:"Dental Development and Anomalies in Cleft Lip and Palate",slug:"dental-development-and-anomalies-in-cleft-lip-and-palate",totalDownloads:959,totalCrossrefCites:0,signatures:"Elaine Li Yen Tan and Mimi Yow",reviewType:"peer-reviewed",authors:[{id:"300481",title:"Dr.",name:"Elaine",middleName:null,surname:"Tan",fullName:"Elaine Tan",slug:"elaine-tan"},{id:"301298",title:"Prof.",name:"Mimi",middleName:null,surname:"Yow",fullName:"Mimi Yow",slug:"mimi-yow"}]},{id:"69989",type:"chapter",title:"Orthodontic Management of Cleft Lip and Palate Patients",slug:"orthodontic-management-of-cleft-lip-and-palate-patients",totalDownloads:1317,totalCrossrefCites:0,signatures:"Geetanjali Sharma",reviewType:"peer-reviewed",authors:[{id:"305902",title:"Dr.",name:"Geetanjali",middleName:null,surname:"Sharma",fullName:"Geetanjali Sharma",slug:"geetanjali-sharma"}]},{id:"70155",type:"chapter",title:"Optimizing Outcomes in Cleft Surgery",slug:"optimizing-outcomes-in-cleft-surgery",totalDownloads:782,totalCrossrefCites:0,signatures:"Eugene Park, Gaurav Deshpande, Bjorn Schonmeyr, Carolina Restrepo and Alex Campbell",reviewType:"peer-reviewed",authors:[{id:"300004",title:"Dr.",name:"Eugene",middleName:null,surname:"Park",fullName:"Eugene Park",slug:"eugene-park"},{id:"301140",title:"Dr.",name:"Alex",middleName:null,surname:"Campbell",fullName:"Alex Campbell",slug:"alex-campbell"},{id:"310251",title:"Dr.",name:"Gaurav",middleName:null,surname:"Deshpande",fullName:"Gaurav Deshpande",slug:"gaurav-deshpande"},{id:"310252",title:"Dr.",name:"Bjorn",middleName:null,surname:"Schonmeyr",fullName:"Bjorn Schonmeyr",slug:"bjorn-schonmeyr"},{id:"310253",title:"Dr.",name:"Carolina",middleName:null,surname:"Restrepo",fullName:"Carolina Restrepo",slug:"carolina-restrepo"}]},{id:"70294",type:"chapter",title:"Anesthesia Considerations in the Perioperative of Patients with Lip and Palate Length",slug:"anesthesia-considerations-in-the-perioperative-of-patients-with-lip-and-palate-length",totalDownloads:712,totalCrossrefCites:0,signatures:"Silvia Peña, Claudia Paulina Reyes, Andres Felipe Beltran and Ofelia Ham",reviewType:"peer-reviewed",authors:[{id:"241227",title:"Dr.",name:"Silvia",middleName:null,surname:"Pena-Olvera",fullName:"Silvia Pena-Olvera",slug:"silvia-pena-olvera"}]},{id:"69846",type:"chapter",title:"Orthognathic Surgery in Cleft Lip and Palate Patients",slug:"orthognathic-surgery-in-cleft-lip-and-palate-patients",totalDownloads:920,totalCrossrefCites:1,signatures:"Hakan Yilmaz and Arzu Ari Demirkaya",reviewType:"peer-reviewed",authors:[{id:"306192",title:"M.Sc.",name:"Hakan",middleName:null,surname:"Yilmaz",fullName:"Hakan Yilmaz",slug:"hakan-yilmaz"},{id:"306194",title:"Prof.",name:"Arzu",middleName:null,surname:"Ari Demirkaya",fullName:"Arzu Ari Demirkaya",slug:"arzu-ari-demirkaya"}]},{id:"71216",type:"chapter",title:"Quality of Life in Adolescents with Cleft Lip and Palate",slug:"quality-of-life-in-adolescents-with-cleft-lip-and-palate",totalDownloads:689,totalCrossrefCites:0,signatures:"Latifa Elmouden, Fatima Zahra Elgasmi and Lahcen Ousehal",reviewType:"peer-reviewed",authors:[{id:"306236",title:"Dr.",name:"Latifa",middleName:null,surname:"El Mouden",fullName:"Latifa El Mouden",slug:"latifa-el-mouden"},{id:"316369",title:"Dr.",name:"Fatima Zahra",middleName:null,surname:"Elgasmi",fullName:"Fatima Zahra Elgasmi",slug:"fatima-zahra-elgasmi"},{id:"316371",title:"Prof.",name:"Lahcen",middleName:null,surname:"Ousehal",fullName:"Lahcen Ousehal",slug:"lahcen-ousehal"}]}]},relatedBooks:[{type:"book",id:"2988",title:"A Textbook of Advanced Oral and Maxillofacial Surgery",subtitle:null,isOpenForSubmission:!1,hash:"b5d9f2be309d43646fca5ce2cd1e3d19",slug:"a-textbook-of-advanced-oral-and-maxillofacial-surgery",bookSignature:"Mohammad Hosein Kalantar Motamedi",coverURL:"https://cdn.intechopen.com/books/images_new/2988.jpg",editedByType:"Edited by",editors:[{id:"90148",title:"Dr.",name:"Mohammad Hosein",surname:"Motamedi",slug:"mohammad-hosein-motamedi",fullName:"Mohammad Hosein Motamedi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"44949",title:"Complications Following Surgery of Impacted Teeth and Their Management",slug:"complications-following-surgery-of-impacted-teeth-and-their-management",signatures:"Çetin Kasapoğlu, Amila Brkić, Banu Gürkan-Köseoğlu and Hülya\nKoçak-Berberoğlu",authors:[{id:"111192",title:"Ph.D.",name:"Amila",middleName:null,surname:"Brkic",fullName:"Amila Brkic",slug:"amila-brkic"},{id:"160519",title:"Prof.",name:"Banu",middleName:null,surname:"Gürkan-Köseoğlu",fullName:"Banu Gürkan-Köseoğlu",slug:"banu-gurkan-koseoglu"},{id:"160520",title:"Prof.",name:"Hülya",middleName:null,surname:"Koçak-Berberoğlu",fullName:"Hülya Koçak-Berberoğlu",slug:"hulya-kocak-berberoglu"},{id:"160522",title:"Prof.",name:"Çetin",middleName:null,surname:"Kasapoğlu",fullName:"Çetin Kasapoğlu",slug:"cetin-kasapoglu"}]},{id:"44967",title:"New Concepts in Impacted Third Molar Surgery",slug:"new-concepts-in-impacted-third-molar-surgery",signatures:"Mohammad Hosein Kalantar Motamedi and Farshid Kavandi",authors:[{id:"166975",title:"Dr.",name:"Farshid",middleName:null,surname:"Kavandi",fullName:"Farshid Kavandi",slug:"farshid-kavandi"}]},{id:"44950",title:"Odontogenic Infections",slug:"odontogenic-infections",signatures:"Onur Gonul, Sertac Aktop, Tulin Satilmis, Hasan Garip and Kamil\nGoker",authors:[{id:"86656",title:"Dr.",name:"Hasan",middleName:null,surname:"Garip",fullName:"Hasan Garip",slug:"hasan-garip"},{id:"87174",title:"Dr.",name:"Tülin",middleName:null,surname:"Satılmış",fullName:"Tülin Satılmış",slug:"tulin-satilmis"},{id:"87224",title:"Prof.",name:"Kamil",middleName:null,surname:"Göker",fullName:"Kamil Göker",slug:"kamil-goker"},{id:"166953",title:"Dr.",name:"Sertac",middleName:null,surname:"Aktop",fullName:"Sertac Aktop",slug:"sertac-aktop"},{id:"166970",title:"Dr.",name:"Onur",middleName:null,surname:"Gonul",fullName:"Onur Gonul",slug:"onur-gonul"}]},{id:"41009",title:"Non-Odontogenic Oral and Maxillofacial Infections",slug:"non-odontogenic-oral-and-maxillofacial-infections",signatures:"Petr Schütz and Hussein Hassan Hamed Ibrahim",authors:[{id:"154334",title:"Dr.",name:"Petr",middleName:null,surname:"Schütz",fullName:"Petr Schütz",slug:"petr-schutz"},{id:"166898",title:"Dr.",name:"Hussein Hassan Hamed",middleName:null,surname:"Ibrahim",fullName:"Hussein Hassan Hamed Ibrahim",slug:"hussein-hassan-hamed-ibrahim"}]},{id:"44249",title:"Diagnosis and Management of Common Oral and Maxillofacial Lesions",slug:"diagnosis-and-management-of-common-oral-and-maxillofacial-lesions",signatures:"Taghi Azizi",authors:[{id:"166841",title:"Dr.",name:"Taghi",middleName:null,surname:"Azizi",fullName:"Taghi Azizi",slug:"taghi-azizi"}]},{id:"44992",title:"Treatment of Large Cysts of the Mandible with Autografts of Cancellous Bone from the Tibia",slug:"treatment-of-large-cysts-of-the-mandible-with-autografts-of-cancellous-bone-from-the-tibia",signatures:"Piotr Malara",authors:[{id:"152421",title:"Prof.",name:"Piotr",middleName:null,surname:"Malara",fullName:"Piotr Malara",slug:"piotr-malara"}]},{id:"44277",title:"Keratocystic Odontogenic Tumors – Clinical and Molecular Features",slug:"keratocystic-odontogenic-tumors-clinical-and-molecular-features",signatures:"Miroslav Andrić, Božidar Brković, Vladimir Jurišić, Milan Jurišić and\nJelena Milašin",authors:[{id:"49081",title:"Dr.",name:"Miroslav",middleName:null,surname:"Andric",fullName:"Miroslav Andric",slug:"miroslav-andric"},{id:"64273",title:"Dr.",name:"Jelena",middleName:null,surname:"Milašin",fullName:"Jelena Milašin",slug:"jelena-milasin"},{id:"84391",title:"Prof.",name:"Vladimir",middleName:null,surname:"Jurisic",fullName:"Vladimir Jurisic",slug:"vladimir-jurisic"},{id:"162943",title:"Dr.",name:"Bozidar",middleName:null,surname:"Brkovic",fullName:"Bozidar Brkovic",slug:"bozidar-brkovic"},{id:"162944",title:"Prof.",name:"Milan",middleName:null,surname:"Jurisic",fullName:"Milan Jurisic",slug:"milan-jurisic"}]},{id:"44951",title:"Marsupialization of Keratocystic Odontogenic Tumors of the Mandible: Longitudinal Image Analysis of Tumor Size via 3D Visualized CT Scans",slug:"marsupialization-of-keratocystic-odontogenic-tumors-of-the-mandible-longitudinal-image-analysis-of-t",signatures:"Hajime Shudou, Masanori Sasaki, Takahiro Yamashiro, Shizuo\nTsunomachi, Yasuharu Takenoshita, Yasutaka Kubota, Tomohiro\nNinomiya, Toshiyuki Kawazu and Yoshihide Mori",authors:[{id:"160624",title:"Dr.",name:"Hajime",middleName:null,surname:"Shudou",fullName:"Hajime Shudou",slug:"hajime-shudou"}]},{id:"44968",title:"Radiation and Chemotherapy in Oral and Maxillofacial Surgery",slug:"radiation-and-chemotherapy-in-oral-and-maxillofacial-surgery",signatures:"Orett E. Ogle and Levon Nikoyan",authors:[{id:"154754",title:"Dr.",name:"Orrett",middleName:null,surname:"Ogle",fullName:"Orrett Ogle",slug:"orrett-ogle"},{id:"163742",title:"Dr.",name:"Levon",middleName:null,surname:"Nikoyan",fullName:"Levon Nikoyan",slug:"levon-nikoyan"}]},{id:"42180",title:"Bisphosphonate-Related Osteonecrosis of the Jaws – Diagnosis and Management",slug:"bisphosphonate-related-osteonecrosis-of-the-jaws-diagnosis-and-management",signatures:"Petia F. Pechalova, Elena G. Poriazova, Nikolai V. Pavlov and Angel\nG. Bakardjiev",authors:[{id:"163314",title:"Associate Prof.",name:"Petia",middleName:null,surname:"Pechalova",fullName:"Petia Pechalova",slug:"petia-pechalova"},{id:"163316",title:"Dr.",name:"Elena",middleName:null,surname:"Poriazova",fullName:"Elena Poriazova",slug:"elena-poriazova"},{id:"163317",title:"Dr.",name:"Nikolai",middleName:null,surname:"Pavlov",fullName:"Nikolai Pavlov",slug:"nikolai-pavlov"},{id:"163318",title:"Prof.",name:"Angel",middleName:"Georgiev",surname:"Bakardjiev",fullName:"Angel Bakardjiev",slug:"angel-bakardjiev"}]},{id:"45010",title:"Vascular Anomalies of the Maxillofacial Region: Diagnosis and Management",slug:"vascular-anomalies-of-the-maxillofacial-region-diagnosis-and-management",signatures:"Faris Fočo and Amila Brkić",authors:[{id:"111192",title:"Ph.D.",name:"Amila",middleName:null,surname:"Brkic",fullName:"Amila Brkic",slug:"amila-brkic"},{id:"162762",title:"Prof.",name:"Faris",middleName:null,surname:"Fočo",fullName:"Faris Fočo",slug:"faris-foco"}]},{id:"44494",title:"Applications of Low Level Laser Therapy",slug:"applications-of-low-level-laser-therapy",signatures:"Vanja Vučićević Boras, Danica Vidović Juras, Ana Andabak Rogulj,\nDragana Gabrić Pandurić, Željko Verzak and Vlaho Brailo",authors:[{id:"159295",title:"Prof.",name:"Vanja",middleName:null,surname:"Vucicevic Boras",fullName:"Vanja Vucicevic Boras",slug:"vanja-vucicevic-boras"}]},{id:"40152",title:"Application of Diode Laser in Oral and Maxillofacial Surgery",slug:"application-of-diode-laser-in-oral-and-maxillofacial-surgery",signatures:"Dragana Gabrić Pandurić, Ivona Bago, Irina Filipović Zore, Mato\nSušić, Davor Katanec, Aleksandar Milenović and Vanja Vučićević\nBoras",authors:[{id:"159295",title:"Prof.",name:"Vanja",middleName:null,surname:"Vucicevic Boras",fullName:"Vanja Vucicevic Boras",slug:"vanja-vucicevic-boras"},{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",fullName:"Dragana Gabrić",slug:"dragana-gabric"},{id:"33434",title:"Prof.",name:"Davor",middleName:null,surname:"Katanec",fullName:"Davor Katanec",slug:"davor-katanec"},{id:"33435",title:"Dr.",name:"Mato",middleName:null,surname:"Sušić",fullName:"Mato Sušić",slug:"mato-susic"},{id:"161983",title:"Prof.",name:"Irina",middleName:null,surname:"Filipović Zore",fullName:"Irina Filipović Zore",slug:"irina-filipovic-zore"},{id:"162745",title:"Dr.",name:"Ivona",middleName:null,surname:"Bago",fullName:"Ivona Bago",slug:"ivona-bago"},{id:"165609",title:"Dr.",name:"Aleksandar",middleName:null,surname:"Milenović",fullName:"Aleksandar Milenović",slug:"aleksandar-milenovic"}]},{id:"44969",title:"Management of Mandibular Fractures",slug:"management-of-mandibular-fractures",signatures:"Amrish Bhagol, Virendra Singh and Ruchi Singhal",authors:[{id:"153817",title:"Dr.",name:"Amrish",middleName:null,surname:"Bhagol",fullName:"Amrish Bhagol",slug:"amrish-bhagol"},{id:"165016",title:"Dr.",name:"Virendra",middleName:null,surname:"Singh",fullName:"Virendra Singh",slug:"virendra-singh"},{id:"165017",title:"Dr.",name:"Ruchi",middleName:null,surname:"Singhal",fullName:"Ruchi Singhal",slug:"ruchi-singhal"}]},{id:"44970",title:"Management of Midfacial Fractures",slug:"management-of-midfacial-fractures",signatures:"Sertac Aktop, Onur Gonul, Tulin Satilmis, Hasan Garip and Kamil\nGoker",authors:[{id:"86656",title:"Dr.",name:"Hasan",middleName:null,surname:"Garip",fullName:"Hasan Garip",slug:"hasan-garip"},{id:"87174",title:"Dr.",name:"Tülin",middleName:null,surname:"Satılmış",fullName:"Tülin Satılmış",slug:"tulin-satilmis"},{id:"87224",title:"Prof.",name:"Kamil",middleName:null,surname:"Göker",fullName:"Kamil Göker",slug:"kamil-goker"},{id:"166953",title:"Dr.",name:"Sertac",middleName:null,surname:"Aktop",fullName:"Sertac Aktop",slug:"sertac-aktop"},{id:"166970",title:"Dr.",name:"Onur",middleName:null,surname:"Gonul",fullName:"Onur Gonul",slug:"onur-gonul"}]},{id:"44952",title:"Distraction Osteogenesis",slug:"distraction-osteogenesis",signatures:"Hossein Behnia, Azita Tehranchi and Golnaz Morad",authors:[{id:"166844",title:"Prof.",name:"Hossein",middleName:null,surname:"Behnia",fullName:"Hossein Behnia",slug:"hossein-behnia"},{id:"167304",title:"Dr.",name:"Azita",middleName:null,surname:"Tehranchi",fullName:"Azita Tehranchi",slug:"azita-tehranchi"},{id:"167305",title:"Dr.",name:"Golnaz",middleName:null,surname:"Morad",fullName:"Golnaz Morad",slug:"golnaz-morad"}]},{id:"44953",title:"Reconstruction of Mandibular Defects",slug:"reconstruction-of-mandibular-defects",signatures:"Maiolino Thomaz Fonseca Oliveira, Flaviana Soares Rocha, Jonas\nDantas Batista, Sylvio Luiz Costa de Moraes and Darceny Zanetta-\nBarbosa",authors:[{id:"160638",title:"Prof.",name:"Maiolino Thomaz Fonseca",middleName:null,surname:"Oliveira",fullName:"Maiolino Thomaz Fonseca Oliveira",slug:"maiolino-thomaz-fonseca-oliveira"},{id:"166562",title:"Prof.",name:"Flaviana Soares",middleName:null,surname:"Rocha",fullName:"Flaviana Soares Rocha",slug:"flaviana-soares-rocha"},{id:"166563",title:"Dr.",name:"Jonas Dantas",middleName:null,surname:"Batista",fullName:"Jonas Dantas Batista",slug:"jonas-dantas-batista"},{id:"166564",title:"Dr.",name:"Sylvio Luiz",middleName:"Costa",surname:"De Moraes",fullName:"Sylvio Luiz De Moraes",slug:"sylvio-luiz-de-moraes"},{id:"166565",title:"Dr.",name:"Darceny",middleName:null,surname:"Zanetta-Barbosa",fullName:"Darceny Zanetta-Barbosa",slug:"darceny-zanetta-barbosa"}]},{id:"44954",title:"Microsurgical Reconstruction of Maxillary Defects",slug:"microsurgical-reconstruction-of-maxillary-defects",signatures:"Shahram Nazerani",authors:[{id:"164036",title:"Prof.",name:"Shahram",middleName:null,surname:"Nazerani",fullName:"Shahram Nazerani",slug:"shahram-nazerani"}]},{id:"44728",title:"Maxillofacial Reconstruction of Ballistic Injuries",slug:"maxillofacial-reconstruction-of-ballistic-injuries",signatures:"Mohammad Hosein Kalantar Motamedi, Seyed Hossein Mortazavi,\nHossein Behnia, Masoud Yaghmaei, Abbas Khodayari, Fahimeh\nAkhlaghi, Mohammad Ghasem Shams and Rashid Zargar Marandi",authors:[{id:"90148",title:"Dr.",name:"Mohammad Hosein",middleName:"Kalantar",surname:"Motamedi",fullName:"Mohammad Hosein Motamedi",slug:"mohammad-hosein-motamedi"}]},{id:"44971",title:"Cleft Lip and Palate Surgery",slug:"cleft-lip-and-palate-surgery",signatures:"Koroush Taheri Talesh and Mohammad Hosein Kalantar Motamedi",authors:[{id:"165544",title:"Prof.",name:"Koroush",middleName:null,surname:"Taheri Talesh",fullName:"Koroush Taheri Talesh",slug:"koroush-taheri-talesh"}]},{id:"40003",title:"The Cosmetic Considerations in Facial Defect Reconstruction",slug:"the-cosmetic-considerations-in-facial-defect-reconstruction",signatures:"Mazen Almasri",authors:[{id:"150413",title:"Dr.",name:"Mazen Ahmad",middleName:null,surname:"Almasri",fullName:"Mazen Ahmad Almasri",slug:"mazen-ahmad-almasri"}]},{id:"44521",title:"Current Advances in Mandibular Condyle Reconstruction",slug:"current-advances-in-mandibular-condyle-reconstruction",signatures:"Tarek El-Bialy and Adel Alhadlaq",authors:[{id:"6203",title:"Dr.",name:"Tarek",middleName:null,surname:"El-Bialy",fullName:"Tarek El-Bialy",slug:"tarek-el-bialy"},{id:"167542",title:"Dr.",name:"Adel",middleName:null,surname:"Alhadlaq",fullName:"Adel Alhadlaq",slug:"adel-alhadlaq"}]},{id:"44972",title:"Concepts in Bone Reconstruction for Implant Rehabilitation",slug:"concepts-in-bone-reconstruction-for-implant-rehabilitation",signatures:"Hany A. Emam and Mark R. Stevens",authors:[{id:"162960",title:"Dr.",name:"Hany",middleName:null,surname:"Emam",fullName:"Hany Emam",slug:"hany-emam"},{id:"162961",title:"Dr.",name:"Mark",middleName:null,surname:"Stevens",fullName:"Mark Stevens",slug:"mark-stevens"}]},{id:"44989",title:"Outfracture Osteotomy Sinus Graft: A Modified Technique Convenient for Maxillary Sinus Lifting",slug:"outfracture-osteotomy-sinus-graft-a-modified-technique-convenient-for-maxillary-sinus-lifting",signatures:"Jeong Keun Lee and Yong Seok Cho",authors:[{id:"25370",title:"Prof.",name:"Jeong Keun",middleName:null,surname:"Lee",fullName:"Jeong Keun Lee",slug:"jeong-keun-lee"},{id:"166214",title:"Dr.",name:"Yong Seok",middleName:null,surname:"Cho",fullName:"Yong Seok Cho",slug:"yong-seok-cho"}]},{id:"44588",title:"Inferior Alveolar Nerve Transpositioning for Implant Placement",slug:"inferior-alveolar-nerve-transpositioning-for-implant-placement",signatures:"Ali Hassani, Mohammad Hosein Kalantar Motamedi and Sarang\nSaadat",authors:[{id:"90148",title:"Dr.",name:"Mohammad Hosein",middleName:"Kalantar",surname:"Motamedi",fullName:"Mohammad Hosein Motamedi",slug:"mohammad-hosein-motamedi"},{id:"163066",title:"Associate Prof.",name:"Ali",middleName:null,surname:"Hassani",fullName:"Ali Hassani",slug:"ali-hassani"},{id:"165825",title:"Dr.",name:"Sarang",middleName:null,surname:"Saadat",fullName:"Sarang Saadat",slug:"sarang-saadat"}]},{id:"44750",title:"Basic and Advanced Operative Techniques in Orthognathic Surgery",slug:"basic-and-advanced-operative-techniques-in-orthognathic-surgery",signatures:"F. Arcuri, M. Giarda, L. Stellin, A. Gatti, M. Nicolotti, M. Brucoli, A.\nBenech and P. Boffano",authors:[{id:"155785",title:"Dr.",name:"Francesco",middleName:null,surname:"Arcuri",fullName:"Francesco Arcuri",slug:"francesco-arcuri"},{id:"165255",title:"Dr.",name:"Livia",middleName:null,surname:"Stellin",fullName:"Livia Stellin",slug:"livia-stellin"},{id:"165256",title:"Dr.",name:"Alessandro",middleName:null,surname:"Gatti",fullName:"Alessandro Gatti",slug:"alessandro-gatti"},{id:"165258",title:"Dr.",name:"Matteo",middleName:null,surname:"Brucoli",fullName:"Matteo Brucoli",slug:"matteo-brucoli"},{id:"165259",title:"Dr.",name:"Mariangela",middleName:null,surname:"Giarda",fullName:"Mariangela Giarda",slug:"mariangela-giarda"},{id:"165260",title:"Prof.",name:"Arnaldo",middleName:null,surname:"Benech",fullName:"Arnaldo Benech",slug:"arnaldo-benech"},{id:"165261",title:"Dr.",name:"Matteo",middleName:null,surname:"Nicolotti",fullName:"Matteo Nicolotti",slug:"matteo-nicolotti"}]},{id:"45357",title:"Rigid Fixation of Intraoral Vertico-Sagittal Ramus Osteotomy for Mandibular Prognathism",slug:"rigid-fixation-of-intraoral-vertico-sagittal-ramus-osteotomy-for-mandibular-prognathism",signatures:"Kazuma Fujimura and Kazuhisa Bessho",authors:[{id:"162569",title:"Associate Prof.",name:"Kazuma",middleName:null,surname:"Fujimura",fullName:"Kazuma Fujimura",slug:"kazuma-fujimura"}]},{id:"38528",title:"Soft-Tissue Response in Orthognathic Surgery Patients Treated by Bimaxillary Osteotomy. Cephalometry Compared with 2-D Photogrammetry",slug:"soft-tissue-response-in-orthognathic-surgery-patients-treated-by-bimaxillary-osteotomy-cephalometry-",signatures:"Jan Rustemeyer",authors:[{id:"159569",title:"Prof.",name:"Jan",middleName:null,surname:"Rustemeyer",fullName:"Jan Rustemeyer",slug:"jan-rustemeyer"}]},{id:"44955",title:"Corticotomy and Miniplate Anchorage for Treating Severe Anterior Open-Bite: Current Clinical Applications",slug:"corticotomy-and-miniplate-anchorage-for-treating-severe-anterior-open-bite-current-clinical-applicat",signatures:"Mehmet Cemal Akay",authors:[{id:"48935",title:"Prof.",name:"Mehmet Cemal",middleName:null,surname:"Akay",fullName:"Mehmet Cemal Akay",slug:"mehmet-cemal-akay"}]},{id:"45007",title:"Office – Based Facial Cosmetic Procedures",slug:"office-based-facial-cosmetic-procedures",signatures:"Farzin Sarkarat, Behnam Bohluli and Roozbeh Kahali",authors:[{id:"73778",title:"Dr.",name:"Behanm",middleName:null,surname:"Bohluli",fullName:"Behanm Bohluli",slug:"behanm-bohluli"},{id:"163344",title:"Dr.",name:"Farzin",middleName:null,surname:"Sarkarat",fullName:"Farzin Sarkarat",slug:"farzin-sarkarat"},{id:"163346",title:"Dr.",name:"Roozbeh",middleName:null,surname:"Kahali",fullName:"Roozbeh Kahali",slug:"roozbeh-kahali"}]},{id:"44956",title:"Facial Sculpturing by Fat Grafting",slug:"facial-sculpturing-by-fat-grafting",signatures:"Behnam Bohluli, Mehran Aghagoli, Farzin Sarkarat, Mansour\nMalekzadeh and Nima Moharamnejad",authors:[{id:"73778",title:"Dr.",name:"Behanm",middleName:null,surname:"Bohluli",fullName:"Behanm Bohluli",slug:"behanm-bohluli"},{id:"163344",title:"Dr.",name:"Farzin",middleName:null,surname:"Sarkarat",fullName:"Farzin Sarkarat",slug:"farzin-sarkarat"}]},{id:"44958",title:"Diagnosis and Management of Temporomandibular Disorders",slug:"diagnosis-and-management-of-temporomandibular-disorders",signatures:"Fina Navi, Mohammad Hosein Kalantar Motamedi, Koroush Taheri\nTalesh, Esshagh Lasemi and Zahra Nematollahi",authors:[{id:"166999",title:"Dr.",name:"Fina",middleName:null,surname:"Navi",fullName:"Fina Navi",slug:"fina-navi"}]}]}],publishedBooks:[{type:"book",id:"7928",title:"Maxillofacial Surgery and Craniofacial Deformity",subtitle:"Practices and Updates",isOpenForSubmission:!1,hash:"734c4a37da9817d5c3aa68c8f15a0d93",slug:"maxillofacial-surgery-and-craniofacial-deformity-practices-and-updates",bookSignature:"Mazen Ahmad Almasri and Raja Kummoona",coverURL:"https://cdn.intechopen.com/books/images_new/7928.jpg",editedByType:"Edited by",editors:[{id:"150413",title:"Dr.",name:"Mazen Ahmad",surname:"Almasri",slug:"mazen-ahmad-almasri",fullName:"Mazen Ahmad Almasri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1170",title:"Maxillofacial Surgery",subtitle:null,isOpenForSubmission:!1,hash:"6925aedd650ca3255c43d0215a6eb837",slug:"maxillofacial-surgery",bookSignature:"Leon Assael",coverURL:"https://cdn.intechopen.com/books/images_new/1170.jpg",editedByType:"Edited by",editors:[{id:"100926",title:"Prof.",name:"Leon",surname:"Assael",slug:"leon-assael",fullName:"Leon Assael"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2988",title:"A Textbook of Advanced Oral and Maxillofacial Surgery",subtitle:null,isOpenForSubmission:!1,hash:"b5d9f2be309d43646fca5ce2cd1e3d19",slug:"a-textbook-of-advanced-oral-and-maxillofacial-surgery",bookSignature:"Mohammad Hosein Kalantar Motamedi",coverURL:"https://cdn.intechopen.com/books/images_new/2988.jpg",editedByType:"Edited by",editors:[{id:"90148",title:"Dr.",name:"Mohammad Hosein",surname:"Motamedi",slug:"mohammad-hosein-motamedi",fullName:"Mohammad Hosein Motamedi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4553",title:"A Textbook of Advanced Oral and Maxillofacial Surgery",subtitle:"Volume 2",isOpenForSubmission:!1,hash:"4af81386d06d6e1495f564629f833620",slug:"a-textbook-of-advanced-oral-and-maxillofacial-surgery-volume-2",bookSignature:"Mohammad Hosein Kalantar Motamedi",coverURL:"https://cdn.intechopen.com/books/images_new/4553.jpg",editedByType:"Edited by",editors:[{id:"90148",title:"Dr.",name:"Mohammad Hosein",surname:"Motamedi",slug:"mohammad-hosein-motamedi",fullName:"Mohammad Hosein Motamedi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5112",title:"A Textbook of Advanced Oral and Maxillofacial Surgery",subtitle:"Volume 3",isOpenForSubmission:!1,hash:"9155af3479cbb41b2af5fc7e333d238f",slug:"a-textbook-of-advanced-oral-and-maxillofacial-surgery-volume-3",bookSignature:"Mohammad Hosein Kalantar Motamedi",coverURL:"https://cdn.intechopen.com/books/images_new/5112.jpg",editedByType:"Edited by",editors:[{id:"90148",title:"Dr.",name:"Mohammad Hosein",surname:"Motamedi",slug:"mohammad-hosein-motamedi",fullName:"Mohammad Hosein Motamedi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[]},onlineFirst:{chapter:{type:"chapter",id:"78817",title:"Polyimide-Derived Graphite Films with High Thermal Conductivity",doi:"10.5772/intechopen.100374",slug:"polyimide-derived-graphite-films-with-high-thermal-conductivity",body:'
1. Introduction
Highly oriented graphite film has excellent electrical and thermal conductivity properties, and is an ideal material indispensable for the development of modern science and technology. It has a very broad application prospect in thermal management field such as modern microelectronic packaging-integration and 5 G wireless communication technologies. In the early 1960s, scientists had used high-temperature pyrolysis deposition technology to prepare highly oriented pyrolytic graphite (HOPG), however, the material needs to be prepared at high temperature (up to 3400-3600°C) and high pressure (10 MPa), the production cycle is long and the production cost is high. Thus, the wide application of such material is subject to certain restrictions [1]. Subsequently, Japanese scientists had initially discovered that polyimide (PI) film with a golden appearance as shown in Figure 1a did not melt during the carbonization process and maintained the original film shape, after high-temperature (2800-3200°C) graphitization treatment, a highly oriented graphite film with a structure close to single crystal graphite can be obtained [3, 4]. Nowadays, PI developed as a thermoresistant polymer has been widely used in different fields, for instance, aromatic PI is often employed as an excellent carbonaceous precursor to prepare various carbon materials with different morphologies (e.g., fiber, film, foam and block) [2]. This is because aromatic PI has many advantages such as wide range of well-defined molecular structure as shown in Figure 1b, relatively high crystallinity and carbon yield.
Figure 1.
(a) Optical appearance and (b) a molecular repeating unit of Kapton PI film [2].
Recently, PI-derived graphite films with high thermal conductivity in the planar direction ranging in 500–1900 W/m K have been successfully produced and practically applied in heat dissipation of many microelectronic devices as shown in Figure 2a. This is attributed to the extensive research on the composition, structure and properties of PI polymer film and related high-temperature heat treatment process have been conducted to improve the thermal conductivity of resultant graphite films and reduce the production cost [2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13]. It is well-known that the thermal conductivity of graphite films is greatly affected by many factors (the quality of PI film precursor, film thickness and heat treatment temperature, etc.). In addition, the microstructural evolution and transformation mechanism [4, 6, 12] of PI polymer during high-temperature heat treatment, the capability of forming an ordered graphite structure and the relevant control strategy need to be further understood. This will make the application of graphite films for thermal management move forward [2, 4, 11].
Figure 2.
(a) Wide heat-dissipation application of PI-derived graphite films in advanced microelectronics and (b) a variety of graphite films classified by different precursors.
2. Diverse graphite films with high thermal conductivity
Generally, high-thermal-conductivity graphite films can be divided into two main types (natural graphite-derived and artificial synthetic films) and several subdivided categories as shown in Figure 2b according to different raw materials: oriented pyrolytic graphite sheet, flexible graphite sheet, graphene-based graphite film, PI-derived graphite film and other carbonaceous precursor derivative.
HOPG sheet refers to polycrystalline graphite film with a high bulk density of ~2.20 g/cm3 and highly oriented graphene layers stacking along the c-axis direction, similar to single crystal graphite as shown in Figure 3 [14]. Its room-temperature thermal conductivity along the a-axis direction of the graphite sheet reaches up to 1600–2000 W/m K [15]. Recently, through a facile and feasible chemical vapor deposition on transition metal substrates, the prepared graphite films possess a high thermal conductivity of 600–1570 W/m K [16, 17].
Figure 3.
(a) Electron channeling pattern and (b) SEM image of HOPG [14].
Flexible graphite sheet is prepared by using natural flake graphite as raw material through several procedures as follows. Firstly, strong acidification treatment for chemical intercalation, then washing, drying and high-temperature expansion to obtain high-expanded graphite worms, and finally calendering and pressing treatment processes. The thermal conductivity of flexible graphite sheet can be adjusted in the range of 200–600 W/m K according to the bulk density and sheet thickness [18, 19]. Because this material does not require high-temperature graphitization and the preparation process is simple, the production cost is relatively low, and it can be used not only as a high-temperature sealing material, but also as a heat dissipation pad for the interface between electronic devices and heat sinks. In addition, the thin graphite sheet has a certain degree of flexibility and can be bent and rolled for storage as shown in Figure 4, which accelerates its low-cost industrial production. However, the mechanical properties of flexible graphite sheet decrease with the increase of thickness. So it is suitable for fields where material strength, toughness and flexural properties are not very high.
Figure 4.
Optical photographs of (a) flexible graphite sheet rolled for store in Nihon carbon and (b) GrafTech graphite sheet production line.
PI graphite film with high crystallinity and preferred orientation is similar to HOPG as shown in Figure 5 and has a high thermal conductivity up to 1900 W/m K in the planar direction [2]. The thermal conductivity of the pyrolytic graphite sheets developed by Panasonic Industry is reported to be 700-1950 W/m K according to their bulk densities (0.85–2.13 g/cm3) and sheet thicknesses (0.10–0.01 mm) [20]. Obviously, the thermal conductivity of graphite sheets is greatly affected by its bulk density, thickness and pyrolysis process. As a rule, the greater the thickness is, the lower the thermal conductivity is.
Figure 5.
(a) Optical photograph and (b) microscopic image of PI-derived thermal pyrolytic graphite sheet (PGS) produced by Panasonic Industry [20].
Recently, there has been numerous studies on making graphene or its precursor (e.g., graphene oxide and reduced graphene oxide) into graphite films as shown in Figure 6a [21, 22, 23]. This extensive research greatly improves the thermal conductivity of graphene-based films up to 2000 W/m K and promotes their various applications [23]. Although the production cost of large-area high-quality graphene films with high thermal conductivity is still high at this stage, the large-scale fabrication in science and industry is rising [21, 22].
Figure 6.
(a) Optical photograph of large-scale preparation of graphene laminated films [21] and (b) the schematic of film fabrication process [22].
3. Preparation technology of graphite films
3.1 Lab-scale preparation
At present, a batch-scale preparation method, i.e., multi-sheet carbonization by laminated molding in a small-sized vacuum induction furnace as shown in Figure 7a, is generally adopted to prepare sheet-like PI-derived graphite films with different sizes. However, this method shows obvious disadvantages such as relatively high production cost, low preparation efficiency, and particularly large energy consumption. Moreover, the size of the films is limited by the graphite mold (which needs to repeatedly endure severe condition under high temperature and high pressure) and the size of the heat treatment furnace.
Figure 7.
Optical photographs of (a) a lab-scale vacuum induction furnace and (b) roll-shaped graphite film prepared from PI film.
3.2 Industrial production
In general, the industrial production of PI-derived graphite films is carried out in multiple sets of large-sized vacuum induction furnace. The emerging advanced rolling-carbonization technology, i.e., directly performing carbonization-graphitization treatment on the roll-shaped organic PI films, could obtain a roll-shaped graphite films with a large size as shown in Figure 7b by controlling the heat treatment process of tightly rolled films. This technology can significantly improve the production efficiency of graphite films, reduce the production cost and improve their mechanical properties.
3.3 New fabrication technology
With the rapid development of graphene and graphene-based materials throughout the world, some new methods, new processes and new technologies [21, 22, 24, 25, 26, 27], such as molecular welding, molecular assembling, flow coating and centrifugal casting, as shown in Figures 6b and 8, have been increasingly developed to fabricate graphene-based graphite films with high thermal conductivity for thermal management application. This will surely provide some reference for the preparation strategy of PI-derived graphite films. It is possible to take advantage of continuous high-temperature carbonization technology as shown in Figure 8b to fabricate large-scale PI-derived graphite films at a low cost in the future.
Figure 8.
Schematics of producing graphene-derived films by different methods (a) the continuous centrifugal casting [26] and (b) the pressurized roll-based production by Joule heating [27].
4. Morphology, structure and properties of PI-derived graphite films
The uniform PI raw film (DuPont Kapton) with a golden color shrinks significantly after 1000°C carbonization and 3000°C graphitization under proper pressure in a vacuum furnace, and the shrinkage rate in the planar direction is about 15% × 15%. The color of the film changes from yellow to black and gray as shown in Figure 9a–c, the carbonized and graphitized samples are brittle and flexible (can be bent at a certain angle >90o at many times), respectively. The molding-press and its pressing strength on the PI films have an important role on the final quality of resultant graphite films as shown in Figure 9d–f.
Figure 9.
Optical photographs of (a) PI raw film, its (b, d and e) 1000°C-carbonized and (c and f) 3000°C-graphitizatized samples made by various molding-press treatments ((b and c) suitable pressure; (d) no pressure; (e) insufficient pressure; and (f) excessive pressure).
As shown in Figure 10, the surface of 1000°C-carbonized carbon films (with a thickness of 50 μm for the raw film) is smooth and the thickness is still uniform, the internals of carbon films exhibit an amorphous carbon structure. After 2000°C graphitization, a local chaotic layered structure can be observed in the cross-section of the films [28]. When the graphitization temperature reaches 2400°C, the cross-section of the films presents a more uniformly oriented layered structure, and as the graphitization temperature further increases up to 3000°C, the layered structure becomes more flatted and ordered, and the graphite-like crystal structure is nearly perfect.
Figure 10.
(a–c) PLM and (d–i) SEM images of the transversal section of PI films heat-treated at different temperatures ((a, d and g) 1000; (b, e and h) 2400; and (c, f and i) 3000°C), (g–i) are high magnification images of (d–f), respectively, and the top right inset in i is the corresponding enlargement.
The thickness and the nature of the PI films have a significant impact on the capability of forming a graphite-like crystal structure. As shown in Figure 11a–c, the PI film with a thickness of 50 μm completely forms a graphite-like layered structure with high crystallinity, and the degree of preferred orientation of the graphene layers is high. The PI films with thicknesses of 75 and 100 μm display a partial graphite-like layered structure and nearly amorphous structure with low crystallinity and poor crystalline orientation, respectively. Some small holes appear on the cross-section of graphite film, which may be related to the removal of non-carbon elements during the high-temperature graphitization process. Moreover, the nature of PI films (e.g., the variety of polymer constituent and molecular structure in various PI films produced by different manufacturers) is very critical to prepare highly oriented graphite films, which has been demonstrated in Figure 11d–f.
Figure 11.
SEM images of the transversal section of 3000°C-graphitized films derived from Kapton PI films with different thicknesses of ((a) 50, (b) 75, (c) 100 μm) and other brand PI film with a thickness of 50 μm at different enlargements (d–f).
The PI laminated sample with a good graphite-like crystal structure as shown in Figure 12 could be prepared by a hot-press method at 2400°C under a certain pressure. It has a uniformly layered structure in the cross-section, and the stacking of PI films is regular and orderly. The PI monolayer film inside the laminated sample still maintains its complete sheet-like structure, which is conducive to the high efficient conduction of heat in the two-dimensional direction of the plane. The PI-derived laminates can be used as a bulk thermally conductive material to further expand the application field of graphite films, but the controllable preparation of such large-size and ultra-thick bulk materials (e.g., blocks) is still difficult [4].
Figure 12.
(a) PLM and (b and c) SEM images of the transversal section of PI film-stacked block made by a suitable molding-press treatment at 2400°C.
It can be seen from the XRD patterns as shown in Figure 13a–c that the PI raw film has a certain degree of orientation owing to the arrangement of aromatic molecules. With the rise of heat treatment temperature, the intensity of diffraction peak of the (002) crystal plane of the PI sample continues to increase. Meanwhile, the microcrystallite accumulation height (Lc) and graphitization degree (g) listed in Table 1 increase step by step. After 3000°C graphitization, the interlayer spacing d002 (0.336 nm) is close to the theoretical value of single crystal graphite (0.3354 nm). The ratio of the two peaks (D and G) as shown in Figure 13d gradually decreases, especially the D peak of 2400°C-graphitized sample completely disappears, which indicates that a three-dimensional ordered graphite structure forms in the graphite film, the content of amorphous carbon and structural defects is very low, and the graphite crystalline size is large [29]. It is worth noting that the microcrystalline size and g of graphite films are affected significantly by the nature (e.g., the extent of biaxial stretching on the original film) and thickness of PI films. The microcrystals in the thick graphite films grow and crystallize slowly, and their preferred orientation is relatively low. As a comparison, the graphite films made from other brand PI show an amorphous structure after graphitization at 3000°C, their microcrystals are small and disordered. The higher the heat-treatment temperature is, the easier the structural transformation completes. Graphitization treatment results in the better growth and crystallization of graphite microcrystals and the preferable orientation of graphene layers in the graphite films.
Figure 13.
(a–c) XRD patterns and (d) Raman spectra of various PI films ((a, b and d) Kapton; (c) other brand) heat-treated at different temperatures.
Microcrystalline parameters of various PI films heat-treated at different temperatures.
Other brand PI film.
Figure 14a shows the room-temperature electrical resistivities of the Kapton PI films after heat treatment at different temperatures. It can be seen that the electrical resistivities of the PI films decrease significantly with the increase of the heat treatment temperature, indicating that the electrical conductivities increase rapidly. The PI film is a polymer insulating material and its volume electrical resistivity is as high as 1016 Ω cm. After 1000°C carbonization treatment, the electrical resistivity reduces by 18 orders of magnitude, to about 54.6 μΩ m, because the PI film has undergone structural changes at this time, most of the heteroatoms are eliminated, and the carbon content increases significantly. At this stage, a local hexagonal-like carbon layer structure forms in the interior of carbon film. The electrical resistivities of the graphitized samples at 2000 and 2800°C are 5.5 and 0.82 μΩ m, respectively. The decline is not very large due to the fact that the conductive path in PI film has been formed around 2000°C. Further graphitization is only to improve its three-dimensional ordered structure with highly preferred orientation as shown in Figure 10. The electrical resistivity of the 3000°C-graphitized PI film is as low as 0.48 μΩ m, which is very close to the theoretical electrical resistivity of single crystal graphite (0.4 μΩ m) in the planar direction [30]. With the rise of heat treatment temperature, the g of PI films continues to increase as listed in Table 1, and its internal graphene layered structure with highly preferred orientation is conducive to the transmission of electrons [2, 4].
Figure 14.
(a) Room-temperature electrical resistivities of PI films heat-treated at different temperatures in the planar direction and (b) micro-structural evolution and transformation mechanism model from PI polymer to ordered graphite film during high-temperature treatment reproduced from [6].
From the above discussion on the morphology and microstructure of the PI films heat-treated at different temperatures, a microstructural change model from PI polymer to ordered graphite at each stage is shown in Figure 14b [6]. The heat-treatment process can be roughly divided into four stages: the first stage (500-1000°C), the second stage (1000-2000°C), the third stage (2000-2400°C) and the fourth stage (2400-3000°C). The whole process reflects that the internal structure of the PI film gradually changes from a disorderly amorphous structure to a highly crystalline graphite structure as the heat treatment temperature progresses [4].
According to the relevant empirical formulas [31], the thermal conductivity of 3000°C-graphitized graphite films (with a thickness of ca. 25 μm) is calculated to be 1143 W/m K. Measured by a laser thermal conductivity meter (NETZSCH LFA 457), its room-temperature thermal diffusion coefficient is ~700 mm2/s, and the corresponding thermal conductivity is measured to be 994 W/m K (the bulk density and specific heat are about 2.0 g/cm3 and 0.71 J/g K, respectively). This excellent conduction performance is attributed to the highly ordered three-dimensional graphite structure of this film material.
5. Influencing factors on thermal conductivity of graphite films
It is well-known to all that the high-thermal-conductivity of carbon materials comes from the strong C—C covalent bonding between carbon atoms and the highly ordered graphite structure stacked by graphene layers and mainly results from the anharmonic vibration of the elastic lattice (i.e., the mutual interaction of phonons) to transfer heat [32]. Single crystal graphite has a hexagonal network layered structure and an anisotropic thermal conductivity, as shown in Figure 15a, its thermal conductivity along the a-axis direction (as high as 2000 W/m K) is much greater than that along the c-axis direction [33]. However, for carbon materials with a disordered graphite structure, the graphene layers with different sizes are stacked randomly, a lower thermal conductivity will yield unexpectedly. There are many critical factors governing the heat-dissipation performance of graphene-assembling carbon materials, such as microcrystalline size, crystalline orientation, structural defects (e.g., vacancies and substitution) and wrinkle deformation in graphene layers as shown in Figure 15b [34].
Figure 15.
(a) Crystal structure of perfect graphite with anisotropic thermal conductivity reproduced from [33] and (b) key factors determining heat dissipation of graphene-assembling film materials [34].
Usually, organic carbonaceous compounds are used as raw materials to prepare carbon materials. Under low temperature at about 300-1000°C, the component containing H, O, N and other non-C elements in organic compounds is gradually decomposed, and C-containing aromatic molecules continue to cyclize and aromatize, which forms C-rich material (i.e., carbon material), and finally through the graphitization process up to 3000°C, pure C material, i.e., graphite material can be obtained. Most of the chemical reactions during the carbonization of precursors are accompanied by the evolution of various gases—different hydrocarbons, carbon oxides, and H2 [35]. It is important to timely remove the pyrolytic gases from the stress-stacked PI films in the highly sealed furnace. The conversion from PI polymer film to graphite film is a typical process of solid phase carbonization. Its prominent characteristic is the similarity in morphology (and shape) of raw material and final product without experiencing a fusion process, which is different from that of liquid phase carbonization [36]. Therefore, selecting proper carbonaceous precursors (e.g. Kapton PI film) and appropriate heat treatment process (e.g., high temperature graphitization under a suitable pressure and duly degassing treatment) to control the growth, accumulation and orientation of graphite microcrystals inside the carbon materials as shown in Figure 16a [37], are essential for obtaining graphite films with high thermal conductivity.
Figure 16.
(a) Marsh-Griffiths model of carbonization-graphitization process on a carbonaceous precursor [37] and (b) a diagram of quality control strategy for high-thermal-conductivity graphite films.
As a result, the thermal conductivity of graphite films mainly depends on the nature of the polymer films and their capability of forming an ordered graphite structure through high-temperature heat treatment as diagramed in Figure 16b. There are three mainly important conditions for obtaining graphite films with high thermal conductivity as follows [2, 4, 7, 28]. Firstly, high carbon content in the large molecules and high carbon yield after carbonization treatment. Secondly, the quality of polymer films (e.g., the constituents and structure of aromatic molecules, high molecular planarity and suitable stiffness as well as molecular orientation degree through the role of biaxial stretching treatment, appropriate film thickness). Thirdly, heat treatment process control (e.g., heating treatment procedure, molding-press condition, non-carbon elements escape, and final graphitization temperature).
6. Latest developments of PI-derived carbons with high thermal conductivity
6.1 Modification of PI precursor to improve the flexibility of graphite films
There is no denying that the PI-derived graphite films with high thermal conductivity after graphitization treatment have a certain degree of brittleness as shown in Figure 17a due to their high stiffness (modulus) and high crystallinity and crystalline orientation, which undoubtedly limits their wide applications. It is difficult to achieve high thermal conductivity and ideal mechanical properties for the graphite films (e.g., internally contradictory indices like high modulus (associating with thermal conductivity) and high flexibility are hardly satisfied simultaneously) except a few reports such as Refs [2, 11, 39, 40]. Nowadays, the modification by doping of PI precursor with graphene (and graphene oxide) and other precursors (e.g., polyacrylonitrile) is a good strategy to improve the flexibility of graphite films with high thermal conductivity [38, 41, 42, 43] as shown in Figure 17b. It is interesting to note that various striking cranes with good flexibility as shown in Figure 18 made with different raw materials by different methods and processes have been successfully prepared [2, 19, 38, 43].
Figure 17.
Optical photographs of (a) highly-oriented PI-derived graphite thin sheet with improved manual handling [11] and (b) superflexible (bending, curling, enwinding, twisting, and knotting) graphene films [38].
Figure 18.
Optical photographs of evolutional crane made of a PI film (a) and after carbonization (b) and graphitization (c) treatments showing good shape-retention and flexibility [2] and (b) various cranes derived from superfoldable graphene film (d) [38], polyacrylonitrile-derived graphite film (e) [43] and flexible graphite sheet (f) [19].
6.2 Versatile forms of PI-derived carbons
Recently, many new forms of PI-derived carbons (including carbon fibers, carbon foams, carbon aerogels and carbon blocks as shown in Figure 19, which are beyond graphite films) with a feature of high thermal conductivity have been fabricated [44, 45, 46, 47, 48, 49, 50, 51]. This extensive and intensive research on PI polymer will expand its application areas. Especially, ultrathick graphene film with a high thickness up to 200 μm while retaining a high thermal conductivity of 1200 W/m K has been achieved [52], which will stimulate the preparation of ultrathick (e.g., millimeter-scale) PI-derived graphite films or large graphite blocks.
Figure 19.
(a–e) SEM images of various PI-derived carbons with high thermal conductivity ((a) carbon nanofibers [44], (b) carbon microfibers [45], (c) carbon bubbles [46], (d) carbon foams [47], (e) carbon aerogels [48]) and (f) optical photograph of highly oriented graphite blocks prepared from PI [49].
6.3 PI-derived composite materials
It is well accepted that graphene-based carbon films as thermal management materials can boost the heat-dissipation performance of film materials in the planar direction [21, 22, 23, 32, 33, 34, 38, 39, 40, 41, 53, 54]. Through new functional composite technologies (e.g., chemical interaction as shown in Figure 20a [53], and modification treatment through doping or hybridizing with other carbonaceous precursors (graphene, carbon nanotube, etc.) and non-carbon fillers such as BN) [53, 54, 55, 56], the thermal conductivity and mechanical flexibility of resultant graphite films can be both enhanced. Furthermore, in the through-plane direction, a superhigh thermal conductivity up to 150 W/m K can be obtained by novel structure design as shown in Figure 20b [54]. This affords carbon materials with a feature of three-dimensional high thermal conductivity (it is beyond the traditional graphite materials with high thermal conductivity only in the planar direction [32]), which will further promote the wide practical applications of carbon materials in thermal management [22, 23, 53, 54, 55, 57, 58, 59].
Figure 20.
(a) A diagram of preparing composite films through the covalent bonding between graphene oxide and PI [53] and (b) a 3-D hybridized structure of composite carbon film made with graphene oxide and PI [54].
7. Conclusions
In a lab-scale study, the Kapton PI-derived graphite films (with a thickness of 50 μm for raw film) show a three-dimensional ordered structure consisting of graphene layers with highly preferred orientation and prefect graphite crystals after graphitization at 3000°C. Their electrical resistivity and thermal conductivity at room temperature in the planar direction are 0.48 μΩ m and ~ 1000 W/m K, respectively. The nature of PI precursor (the molecular structure, planar molecular orientation and film thickness, etc.) and preparation technics (e.g., heat-treatment temperature and molding pressure) have a critical influence on the final conduction performance of graphite films.
In the early time, limited by preparation technology, the thickness of PI-derived graphite films were mainly 20–50 μm, and their thermal conductivity in the planar direction was mostly 300–1000 W/m K. With the continuous improvement of production technology, high-thermal-conductivity graphite film products become more abundant, and some are even industrialized. The 10 μm-thin graphite films can approach a high thermal conductivity of 1900 W/m K. Currently, the thickest product (derived from graphene) is about 200 μm, and its thermal conductivity could reach about 1200 W/m K. However, there is still no breakthrough in the preparation of millimeter-thick graphite films and PI-derived graphite blocks with large sizes. In the future, as the application range widens, the market demand for high-thermal-conductivity graphite films will be more diversified, and the diverse products will also be developed in the direction of wider thickness and higher thermal conductivity.
The emerging modification treatment and composite technology provide a promising strategy not only to improve the comprehensive performance (e.g., high thermal conductivity and good mechanical flexibility) of PI-derived graphite films but also to prepare a variety of new forms of PI-derived carbon materials with high thermal conductivity. Furthermore, polymer-derived carbon materials with a significant feature of three-dimensional high thermal conductivity can be achieved by novel structure design.
At present, high-thermal-conductivity graphite films have been widely used in smart phones, successfully solving the heat dissipation problem of various electronic products. In the near future, with the development of miniaturization and thinning of electronics, high-thermal-conductivity graphite films and other carbon composites with good flexibility will be promisingly used in the field of thermal management as next-generation heat-dissipation components for highly integrated microelectronics, 5 G wireless communication, and high-power smart devices.
Acknowledgments
We acknowledge support of the publication fee by the National Natural Science Foundation of China (Grant No. 52072275).
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"polyimide, graphite film, preparation, structure, property, high thermal conductivity, thermal management",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/78817.pdf",chapterXML:"https://mts.intechopen.com/source/xml/78817.xml",downloadPdfUrl:"/chapter/pdf-download/78817",previewPdfUrl:"/chapter/pdf-preview/78817",totalDownloads:278,totalViews:0,totalCrossrefCites:0,dateSubmitted:"August 12th 2021",dateReviewed:"September 9th 2021",datePrePublished:"September 29th 2021",datePublished:null,dateFinished:"September 29th 2021",readingETA:"0",abstract:"Nowadays, polyimide-derived graphite films with high thermal conductivity have been increasingly applied in many cutting-edge fields needing thermal management, such as highly integrated microelectronics and wireless communication technologies. This chapter first introduces a variety of functional graphite films with high thermal conductivity of 500–2000 W/m K in the planar direction, then provides the preparation technology (including lab-scale preparation and industrial production) and quality control strategy of high-thermal-conductivity graphite films, which are derived from a special polymer- polyimide (PI) by carbonization and graphitization treatments through a suitable molding press in a vacuum furnace. The morphology, microstructure and physical properties as well as the microstructural evolution and transformation mechanism of PI films during the whole process of high-temperature treatment are comprehensively introduced. The nature of PI precursor (e.g., the molecular structure and planar molecular orientation) and preparation technics (e.g., heat-treatment temperature and molding pressure) are critical factors influencing their final physical properties. Currently challenged by the emerging of graphene-based graphite films, the latest developments and future prospects of various PI-derived carbons and composites (beyond films) with high thermal conductivity have been summarized at the end. This chapter may shed light on a promising and versatile utilization of PI-derived functional carbon materials for advanced thermal management.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/78817",risUrl:"/chapter/ris/78817",signatures:"Guanming Yuan and Zhengwei Cui",book:{id:"10702",type:"book",title:"Polyimide",subtitle:null,fullTitle:"Polyimide",slug:null,publishedDate:null,bookSignature:"Dr. Belakatte Parameshwarappa Nandeshwarappa and Dr. Sandeep Chandrashekharappa",coverURL:"https://cdn.intechopen.com/books/images_new/10702.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83969-885-9",printIsbn:"978-1-83969-884-2",pdfIsbn:"978-1-83969-886-6",isAvailableForWebshopOrdering:!0,editors:[{id:"261141",title:"Dr.",name:"Belakatte Parameshwarappa",middleName:null,surname:"Nandeshwarappa",slug:"belakatte-parameshwarappa-nandeshwarappa",fullName:"Belakatte Parameshwarappa Nandeshwarappa"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"308403",title:"Prof.",name:"Guanming",middleName:null,surname:"Yuan",fullName:"Guanming Yuan",slug:"guanming-yuan",email:"yuanguanming@wust.edu.cn",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/308403/images/system/308403.jpg",institution:{name:"Wuhan University of Science and Technology",institutionURL:null,country:{name:"China"}}},{id:"309210",title:"Dr.",name:"Zhengwei",middleName:null,surname:"Cui",fullName:"Zhengwei Cui",slug:"zhengwei-cui",email:"farstar@163.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Wuhan University of Science and Technology",institutionURL:null,country:{name:"China"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Diverse graphite films with high thermal conductivity",level:"1"},{id:"sec_3",title:"3. Preparation technology of graphite films",level:"1"},{id:"sec_3_2",title:"3.1 Lab-scale preparation",level:"2"},{id:"sec_4_2",title:"3.2 Industrial production",level:"2"},{id:"sec_5_2",title:"3.3 New fabrication technology",level:"2"},{id:"sec_7",title:"4. Morphology, structure and properties of PI-derived graphite films",level:"1"},{id:"sec_8",title:"5. Influencing factors on thermal conductivity of graphite films",level:"1"},{id:"sec_9",title:"6. Latest developments of PI-derived carbons with high thermal conductivity",level:"1"},{id:"sec_9_2",title:"6.1 Modification of PI precursor to improve the flexibility of graphite films",level:"2"},{id:"sec_10_2",title:"6.2 Versatile forms of PI-derived carbons",level:"2"},{id:"sec_11_2",title:"6.3 PI-derived composite materials",level:"2"},{id:"sec_13",title:"7. Conclusions",level:"1"},{id:"sec_14",title:"Acknowledgments",level:"1"},{id:"sec_17",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Inagaki M. New Carbons Control of Structure and Functions. Oxford: Elsevier Science Ltd; 2000. pp. 35-39. DOI: 10.1016/B978-008043713-2/50010-8'},{id:"B2",body:'Inagaki M, Ohta N, Hishiyama Y. Aromatic polyimides as carbon precursors. Carbon. 2013;61:1-21. DOI: 10.1016/j.carbon.2013.05.035'},{id:"B3",body:'Burger A, Fitzer E, Heym M, et al. Polyimides as precursors for artificial carbon. Carbon. 1975;13(3):149-157. DOI: 10.1016/0008-6223(75)90225-0'},{id:"B4",body:'Inagaki M, Takeichi T, Hishiyama Y, Oberlin A. High quality graphite films produced from aromatic polyimides. In: Thrower PA, Radovic LR, editors. Chemistry and Physics of Carbon. Volume 26. New York: Marcel Dekker, Inc; 1999. pp. 245-333'},{id:"B5",body:'Hishiyama Y, Yoshida A, Kaburagi Y. Graphite films prepared from carbonized polyimide films. Carbon. 1992;30(3):333-337. DOI: 10.1016/0008-6223(92)90027-T'},{id:"B6",body:'Bourgerette C, Oberlin A, Inagaki M. Structural and textural changes from polyimide Upilex to graphite: Part III. Journal of Materials Research. 1993;8(1):121-130. DOI: 10.1557/JMR.1993.0121'},{id:"B7",body:'Hishiyama Y, Nakamura M, Nagata Y, et al. Graphitization behavior of carbon film prepared from high modulus polyimide film: synthesis of high-quality graphite film. Carbon. 1994;32(4):645-650. DOI: 10.1016/0008-6223(94)90085-X'},{id:"B8",body:'Kaburagi Y, Hishiyama Y. Highly crystallized graphite films prepared by high-temperature heat treatment from carbonized aromatic polyimide films. Carbon. 1995;33(6):773-777. DOI: 10.1016/0008-6223(95)00009-3'},{id:"B9",body:'Hishiyama Y, Igarashi K, Kanaoka I, et al. Graphitization behavior of Kapton-derived carbon film related to structure, microtexture and transport properties. Carbon. 1997;35(5):657-668. DOI: 10.1016/S0008-6223(97)00021-3'},{id:"B10",body:'Zhong DH, Sano H, Kobayashi K, Uchiyama Y. A study of film thickness dependence of the graphitizability of PMDA–ODA polyimide-derived carbon film. Carbon. 2000;38(15):2161-2165. DOI: 10.1016/S0008-6223(00)00075-0'},{id:"B11",body:'Murakami M, Tatami A, Tachibana M. Fabrication of high quality and large area graphite thin films by pyrolysis and graphitization of polyimides. Carbon. 2019;145:23-30. DOI: 10.1016/j.carbon.2018.12.057'},{id:"B12",body:'Kato T, Yamada, Y, Nishikawa Y, et al. Carbonization mechanisms of polyimide: Methodology to analyze carbon materials with nitrogen, oxygen, pentagons, and heptagons. Carbon. 2021;178:58-80. DOI: 10.1016/j.carbon.2021.02.090'},{id:"B13",body:'Murashima K, Kawashima Y, Ozaki S, et al. Modified-edge-support heat treatment method of polyimide for crystalline, large-area, and self-standing ultrathin graphite films. Carbon. 2021;181:348-357. DOI: 10.1016/j.carbon.2021.05.036'},{id:"B14",body:'Inagaki M, Kang FY. Materials Science and Engineering of Carbon: Fundamentals. 2nd Edition. Beijing: Tsinghua University Press; 2014. p. 265. DOI: 10.1016/C2013-0-13699-9'},{id:"B15",body:'Bertram A, Beasley K, Torre W. An overview of navy composite developments for thermal management. Naval Engineers Journal. 1992;104(4):276-285. DOI: 10.1111/j.1559-3584.1992.tb01170.x'},{id:"B16",body:'Zheng Q , Braun PV, Cahill DG. Thermal conductivity of graphite thin films grown by low temperature chemical vapor deposition on Ni (111). Advanced Materials Interfaces. 2016;3(16):1600234. DOI: 10.1002/admi.201600234'},{id:"B17",body:'Kato R, Hasegawa M. Fast synthesis of thin graphite film with high-performance thermal and electrical properties grown by plasma CVD using polycrystalline nickel foil at low temperature. Carbon. 2019;141:768-773. DOI: 10.1016/j.carbon.2018.09.074'},{id:"B18",body:'Hu KS, Chung DDL. Flexible graphite modified by carbon black paste for use as a thermal interface material. Carbon. 2011;49(4):1075-1086. DOI: 10.1016/j.carbon.2010.10.058'},{id:"B19",body:'Hou SY, He SJ, Zhu TL, et al. Environment-friendly preparation of exfoliated graphite and functional graphite sheets. Journal of Materiomics. 2021;7(1):136-145. DOI: 10.1016/j.jmat.2020.06.009'},{id:"B20",body:'Thermal protection sheet (Graphite Sheet (PGS)/PGS applied products/NASBIS). https://industrial.panasonic.com/ww/products/pt/pgs'},{id:"B21",body:'Wu TS, Xu YL, Wang HY, Sun ZH, Zou LY. Efficient and inexpensive preparation of graphene laminated film with ultrahigh thermal conductivity. Carbon. 2021;171:639-645. DOI: 10.1016/j.carbon.2020.09.039'},{id:"B22",body:'Chen S, Wang Q , Zhang M, et al. Scalable production of thick graphene films for next generation thermal management applications. Carbon. 2020;167:270-277. DOI: 10.1016/j.carbon.2020.06.030'},{id:"B23",body:'Song NJ, Chen CM, Lu CX, et al. Thermally reduced graphene oxide films as flexible lateral heat spreaders. Journal of Materials Chemistry A. 2014;2(39):16563-16568. DOI: 10.1039/C4TA02693D'},{id:"B24",body:'Li HL, Dai SC, Miao J, et al. Enhanced thermal conductivity of graphene/polyimide hybrid film via a novel “molecular welding” strategy. Carbon. 2018;126:319-327. DOI: 10.1016/j.carbon.2017.10.044'},{id:"B25",body:'Akbari A, Cunning BV, Joshi SR, et al. Highly ordered and dense thermally conductive graphitic films from a graphene oxide/reduced graphene oxide mixture. Matter. 2020;2(5):1198-1206. DOI: 10.1016/j.matt.2020.02.014'},{id:"B26",body:'Zhong J, Sun W, Wei Q , et al. Efficient and scalable synthesis of highly aligned and compact two-dimensional nanosheet films with record performances. Nature Communications. 2018;9(1):3484. DOI: 10.1038/s41467-018-05723-2'},{id:"B27",body:'Liu YJ, Li P, Wang F, et al. Rapid roll-to-roll production of graphene films using intensive Joule heating. Carbon. 2019;155:462-468. DOI: 10.1016/j.carbon.2019.09.021'},{id:"B28",body:'Yuan GM, Li XK, Dong ZJ, et al. Preparation and characterization of graphite films with high thermal conductivity. Functional Materials. 2015;46(17):17097-17101. DOI: 10.15541/jim20160156'},{id:"B29",body:'Tuinstra F, Koenig JL. Raman spectrum of graphite. Journal of Chemical Physics. 1970;53(3):1126-1130. DOI: 10.1063/1.1674108'},{id:"B30",body:'Dutta AK. Electrical conductivity of single crystals of graphite. Physical Review. 1953;90(2):187-192. DOI: 10.1103/PhysRev.90.187'},{id:"B31",body:'Lavin JG, Boyington DR, Lahijani J, et al. The correlation of thermal conductivity with electrical resistivity in mesophase pitch-based carbon fiber. Carbon. 1993;31(6):1001-1002. DOI: 10.1016/0008-6223(93)90207-Q'},{id:"B32",body:'Taylor R. The thermal conductivity of pyrolytic graphite. Philosophical Magazine. 1966;13(8):157-166. DOI: 10.1080/14786436608211993'},{id:"B33",body:'Norley J. The role of natural graphite in electronics cooling. Electronics Cooling Magazine. 2001. http://www.electronics-cooling.com/2001/08/the-role-of-natural-graphite-in-electronics-cooling'},{id:"B34",body:'Pop E, Varshney V, Roy AK. Thermal properties of graphene: fundamentals and applications. MRS Bulletin. 2012;37(12):1273-1281. DOI: 10.1557/mrs.2012.203'},{id:"B35",body:'Inagaki M, Kang FY, Toyoda M, Konno H. Advanced Materials Science and Engineering of Carbon. Beijing: Tsinghua University Press; 2013. p. 68. DOI: 10.1016/C2012-0-03601-0'},{id:"B36",body:'Yuan GM, Cui ZW. Preparation, characterization, and applications of carbonaceous mesophase: a review. In: Ghamsari MS, Carlescu I, editors. Liquid Crystals and Display Technology. IntechOpen; 2020. pp. 101-120. DOI: 10.5772/intechopen.88860'},{id:"B37",body:'Marsh H. Introduction to Carbon Science. London: Butterworths; 1989. pp. 7-8'},{id:"B38",body:'Peng L, Xu Z, Liu Z, et al. Ultrahigh thermal conductive yet superflexible graphene films. Advanced Material. 2017;29 (27):1700589. DOI: 10.1002/adma.201700589'},{id:"B39",body:'Wang N, Samani MK, Li H, et al. Tailoring the thermal and mechanical properties of graphene film by structural engineering. Small. 2018;14(29):1801346. DOI: 10.1002/smll.201801346'},{id:"B40",body:'Wang B, Cunning BV, Kim NY, et al. Ultrastiff, strong, and highly thermally conductive crystalline graphitic films with mixed stacking order. Advanced Materials. 2019;31(29):1903039. DOI: 10.1002/adma.201903039'},{id:"B41",body:'Ma LR, Wang YX, Wang YY, et al. Graphene induced carbonization of polyimide films to prepared flexible carbon films with improving-thermal conductivity. Ceramics International. 2020;46:3332-3338. DOI: 10.1016/j.ceramint.2019.10.042'},{id:"B42",body:'Wang K, Li MX, Zhang JJ, Lu HB. Polyacrylonitrile coupled graphite oxide film with improved heat dissipation ability. Carbon. 2019;144: 249-258. DOI: 10.1016/j.carbon.2018.12.027'},{id:"B43",body:'Huang HG, Ming X, Wang YZ, et al. Polyacrylonitrile-derived thermally conductive graphite film via graphene template effect. Carbon. 2021;180:197-203. DOI: 10.1016/j.carbon.2021.04.090'},{id:"B44",body:'Yan H, Mahanta NK, Wang BJ, et al. Structural evolution in graphitization of nanofibers and mats from electrospun polyimide–mesophase pitch blends. Carbon. 2014;71:303-318. DOI: 10.1016/j.carbon.2014.01.057'},{id:"B45",body:'Li A, Ma ZK, Song HH, et al. The effect of liquid stabilization on the structures and the conductive properties of polyimide-based graphite fibers. RSC Advance. 2015;5:79565-79571. DOI: 10.1039/C5RA10497A'},{id:"B46",body:'Tao ZC, Wang HB, Lian PF, et al. “Graphitic bubbles” derived from polyimide film. Carbon. 2017;116:733-736. DOI: 10.1016/j.carbon.2017.02.044'},{id:"B47",body:'Ou AP, Huang Z, Qin R, et al. Preparation of thermosetting/thermoplastic polyimide foam with pleated cellular structure via in situ simultaneous orthogonal polymerization. ACS Applied Polymer Materials. 2019;1(9):2430-2440. DOI: 10.1021/acsapm.9b00558'},{id:"B48",body:'Feng JZ, Wang X, Jiang YG, et al. Study on thermal conductivities of aromatic polyimide aerogels. ACS Applied Materials & Interfaces. 2016;8(20):12992-12996. DOI: 10.1021/acsami.6b02183'},{id:"B49",body:'Murakami M, Nishiki N, Knakamura K, et al. High-quality and highly oriented graphite block from polycondensation polymer films. Carbon. 1992;30(2):255-262. DOI: 10.1016/0008-6223(92)90088-E'},{id:"B50",body:'Wang JM, Li QX, Liu D, et al. High temperature thermally conductive nanocomposite textile by “green” electrospinning. Nanoscale. 2018;10:16868-16872. DOI: 10.1039/C8NR05167D'},{id:"B51",body:'Kausar A. Emerging polyimide and graphene derived nanocomposite foam: research and technical tendencies. Journal of Macromolecular Science, Part A: Pure and Applied Chemistry. 2021;58(10):643-658. DOI: 10.1080/10601325.2021.1934011'},{id:"B52",body:'Zhang XD, Guo Y, Liu YJ, et al. Ultrathick and highly thermally conductive graphene films by self-fusion. Carbon. 2020;167:249-255. DOI: 10.1016/j.carbon.2020.05.051'},{id:"B53",body:'Zhu Y, Peng QY, Qin YY, et al. Graphene-carbon composite films as thermal management materials. ACS Applied Nano Materials. 2020;3(9):9076-90887. DOI: 10.1021/acsanm.0c01754'},{id:"B54",body:'Li YH, Zhu YF, Jiang GP, et al. Boosting the heat dissipation performance of graphene/polyimide flexible carbon film via enhanced through-plane conductivity of 3D hybridized structure. Small. 2020;16(8):1903315. DOI: 10.1002/smll.201903315'},{id:"B55",body:'Ning Wen, Wang ZH, Liu P, et al. Multifunctional super-aligned carbon nanotube/polyimide composite film heaters and actuators. Carbon. 2018;139:1136-1143. DOI: 10.1016/j.carbon.2018.08.011'},{id:"B56",body:'Ou XH, Chen SS, Lu XM, Lu QH. Enhancement of thermal conductivity and dimensional stability of polyimide/boron nitride films through mechanochemistry. Composites Communications. 2021,23:100549. DOI: 10.1016/j.coco.2020.100549'},{id:"B57",body:'Loeblein M, Bolker A, Tsang SH, et al. 3D Graphene-infused polyimide with enhanced electrothermal performance for long-term flexible space applications. Small. 2015;11(48):6425-6434. DOI: 10.1002/smll.201502670'},{id:"B58",body:'Wang Y, Wang HT, Liu F, et al. Flexible printed circuit board based on graphene/polyimide composites with excellent thermal conductivity and sandwich structure. Composites Part A: Applied Science and Manufacturing. 2020;138(44):106075. DOI: 10.1016/j.compositesa.2020.106075'},{id:"B59",body:'Luo XH, Guo QG, Li XF, et al. Experimental investigation on a novel phase change material composites coupled with graphite film used for thermal management of lithium-ion batteries. Renewable Energy. 2020;145:2046-2055. DOI: 10.1016/j.renene.2019.07.112'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Guanming Yuan",address:"yuanguanming@wust.edu.cn",affiliation:'
The State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science and Technology, China
Hubei Province Key Laboratory of Coal Conversion and New Carbon Materials, Wuhan University of Science and Technology
The State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science and Technology, China
Hubei Province Key Laboratory of Coal Conversion and New Carbon Materials, Wuhan University of Science and Technology
'}],corrections:null},book:{id:"10702",type:"book",title:"Polyimide",subtitle:null,fullTitle:"Polyimide",slug:null,publishedDate:null,bookSignature:"Dr. Belakatte Parameshwarappa Nandeshwarappa and Dr. Sandeep Chandrashekharappa",coverURL:"https://cdn.intechopen.com/books/images_new/10702.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83969-885-9",printIsbn:"978-1-83969-884-2",pdfIsbn:"978-1-83969-886-6",isAvailableForWebshopOrdering:!0,editors:[{id:"261141",title:"Dr.",name:"Belakatte Parameshwarappa",middleName:null,surname:"Nandeshwarappa",slug:"belakatte-parameshwarappa-nandeshwarappa",fullName:"Belakatte Parameshwarappa Nandeshwarappa"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"185562",title:"Prof.",name:"Hongping",middleName:null,surname:"Lan",email:"971568608@qq.com",fullName:"Hongping Lan",slug:"hongping-lan",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"51981",title:"An Operational Statistical Scheme for Tropical Cyclone-Induced Rainfall Forecast",slug:"an-operational-statistical-scheme-for-tropical-cyclone-induced-rainfall-forecast",abstract:"Nonparametric methods are used in this study to analyze and predict short-term rainfall due to tropical cyclones (TCs) in a coastal meteorological station. All 427 TCs during 1953–2011, which made landfall along the Southeast China coast with a distance less than 700 km to a certain meteorological station, Shenzhen, are analyzed and grouped according to their landfalling direction, distance, and intensity. The corresponding daily rainfall records at Shenzhen Meteorological Station (SMS) during TCs landfalling period (a couple of days before and after TC landfall) are collected. The maximum daily rainfall (R24) and maximum 3-day accumulative rainfall (R72) records at SMS for each TC category are analyzed by a nonparametric statistical method, percentile estimation. The results are plotted by statistical boxplot, expressing in the probability of precipitation. The performance of the statistical boxplots was evaluated to forecast the short-term rainfall at SMS during the TC seasons in 2012 and 2013. The results show that the boxplot scheme can be used as a valuable reference to predict the short-term rainfall at SMS due to TCs landfalling along the Southeast China coast.",signatures:"Qinglan Li, Hongping Lan, Johnny C.L. Chan, Chunyan Cao, Cheng Li\nand Xingbao Wang",authors:[{id:"179370",title:"Dr.",name:"Qinglan",surname:"Li",fullName:"Qinglan Li",slug:"qinglan-li",email:"ql.li@siat.ac.cn"},{id:"185562",title:"Prof.",name:"Hongping",surname:"Lan",fullName:"Hongping Lan",slug:"hongping-lan",email:"971568608@qq.com"},{id:"185563",title:"Prof.",name:"Johnny C.L.",surname:"Chan",fullName:"Johnny C.L. Chan",slug:"johnny-c.l.-chan",email:"Johnny.Chan@cityu.edu.hk"},{id:"185564",title:"Ms.",name:"Chunyan",surname:"Cao",fullName:"Chunyan Cao",slug:"chunyan-cao",email:"675588@qq.com"},{id:"185565",title:"Mr.",name:"Cheng",surname:"Li",fullName:"Cheng Li",slug:"cheng-li",email:"11798629@qq.com"},{id:"185566",title:"Dr.",name:"Xingbao",surname:"Wang",fullName:"Xingbao Wang",slug:"xingbao-wang",email:"Xingbao.Wang@bom.gov.au"}],book:{id:"5180",title:"Tropical Cyclone Dynamics, Prediction, and Detection",slug:"recent-developments-in-tropical-cyclone-dynamics-prediction-and-detection",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"179302",title:"Dr.",name:"Andrew",surname:"Mercer",slug:"andrew-mercer",fullName:"Andrew Mercer",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Mississippi State University",institutionURL:null,country:{name:"United States of America"}}},{id:"179303",title:"Prof.",name:"Jiayi",surname:"Pan",slug:"jiayi-pan",fullName:"Jiayi Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/179303/images/system/179303.jpg",biography:"Professor Jiayi Pan received his Ph.D. in Physical Oceanography from the Institute of Oceanology, Chinese Academy of Sciences in 1996. He was a postdoctoral researcher at the University of Delaware from 1999 to 2003, then worked at the University of Southern Mississippi, Oregon Health and Science University, and Portland State University in 2003-2004, 2004-2005, and 2005-2009, respectively. He joined the Institute of Space and Earth Information Science, the Chinese University of Hong Kong as an associate professor in February 2009. Professor Jiayi Pan has been engaged in research on ocean remote sensing, air-sea interaction, estuarine dynamics, and internal wave dynamics for many years, and was the principal investigator (PI) or Co-PI for a number of research projects. In July 2019, he joined the School of Geography and Environment, Jiangxi Normal University as a distinguished professor.",institutionString:"Jiangxi Normal University",institution:{name:"Chinese University of Hong Kong",institutionURL:null,country:{name:"China"}}},{id:"179513",title:"Dr.",name:"Wen-Zhou",surname:"Zhang",slug:"wen-zhou-zhang",fullName:"Wen-Zhou Zhang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Xiamen University",institutionURL:null,country:{name:"China"}}},{id:"180358",title:"Dr.",name:"Yujuan",surname:"Sun",slug:"yujuan-sun",fullName:"Yujuan Sun",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"180359",title:"Prof.",name:"William",surname:"Perrie",slug:"william-perrie",fullName:"William Perrie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"180488",title:"BSc.",name:"Sheng",surname:"Lin",slug:"sheng-lin",fullName:"Sheng Lin",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"180491",title:"BSc.",name:"Xue-Min",surname:"Jiang",slug:"xue-min-jiang",fullName:"Xue-Min Jiang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"185770",title:"Dr.",name:"Kevin K. W.",surname:"Cheung",slug:"kevin-k.-w.-cheung",fullName:"Kevin K. W. Cheung",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"185927",title:"Ms.",name:"Alexandria",surname:"Grimes",slug:"alexandria-grimes",fullName:"Alexandria Grimes",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"189105",title:"Mr.",name:"Guoping",surname:"Zhang",slug:"guoping-zhang",fullName:"Guoping Zhang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"open-access-funding",title:"Open Access Funding",intro:"
IntechOpen’s Academic Editors and Authors have received funding for their work through many well-known funders, including: the European Commission, Bill and Melinda Gates Foundation, Wellcome Trust, Chinese Academy of Sciences, Natural Science Foundation of China (NSFC), CGIAR Consortium of International Agricultural Research Centers, National Institute of Health (NIH), National Science Foundation (NSF), National Aeronautics and Space Administration (NASA), National Institute of Standards and Technology (NIST), German Research Foundation (DFG), Research Councils United Kingdom (RCUK), Oswaldo Cruz Foundation, Austrian Science Fund (FWF), Foundation for Science and Technology (FCT), Australian Research Council (ARC).
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\\n\\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\\n\\n
\\n\\t
Does your institution already have a budget for covering Open Access publication costs?
\\n\\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\\n
\\n\\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\\n\\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\\n\\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\n\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\n\n
\n\t
Does your institution already have a budget for covering Open Access publication costs?
\n\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\n
\n\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\n\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\n\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"58592",title:"Dr.",name:"Arun",middleName:null,surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58592/images/1664_n.jpg",biography:"Arun K. Shanker is serving as a Principal Scientist (Plant Physiology) with the Indian Council of Agricultural Research (ICAR) at the Central Research Institute for Dryland Agriculture in Hyderabad, India. He is working with the ICAR as a full time researcher since 1993 and has since earned his Advanced degree in Crop Physiology while in service. He has been awarded the prestigious Member of the Royal Society of Chemistry (MRSC), by the Royal Society of Chemistry, London in 2015. Presently he is working on systems biology approach to study the mechanism of abiotic stress tolerance in crops. His main focus now is to unravel the mechanism of drought and heat stress response in plants to tackle climate change related threats in agriculture.",institutionString:null,institution:{name:"Indian Council of Agricultural Research",country:{name:"India"}}},{id:"4782",title:"Prof.",name:"Bishnu",middleName:"P",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4782/images/system/4782.jpg",biography:"Bishnu P. Pal is Professor of Physics at Mahindra École\nCentrale Hyderabad India since July 1st 2014 after retirement\nas Professor of Physics from IIT Delhi; Ph.D.’1975 from IIT\nDelhi; Fellow of OSA and SPIE; Senior Member IEEE;\nHonorary Foreign Member Royal Norwegian Society for\nScience and Arts; Member OSA Board of Directors (2009-\n11); Distinguished Lecturer IEEE Photonics Society (2005-\n07).",institutionString:null,institution:{name:"Indian Institute of Technology Delhi",country:{name:"India"}}},{id:"69653",title:"Dr.",name:"Chusak",middleName:null,surname:"Limsakul",slug:"chusak-limsakul",fullName:"Chusak Limsakul",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Prince of Songkla University",country:{name:"Thailand"}}},{id:"23804",title:"Dr.",name:"Hamzah",middleName:null,surname:"Arof",slug:"hamzah-arof",fullName:"Hamzah Arof",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/23804/images/5492_n.jpg",biography:"Hamzah Arof received his BSc from Michigan State University, and PhD from the University of Wales. Both degrees were in electrical engineering. His current research interests include signal processing and photonics. Currently he is affiliated with the Department of Electrical Engineering, University of Malaya, Malaysia.",institutionString:null,institution:{name:"University of Malaya",country:{name:"Malaysia"}}},{id:"41989",title:"Prof.",name:"He",middleName:null,surname:"Tian",slug:"he-tian",fullName:"He Tian",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"East China University of Science and Technology",country:{name:"China"}}},{id:"33351",title:null,name:"Hendra",middleName:null,surname:"Hermawan",slug:"hendra-hermawan",fullName:"Hendra Hermawan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/33351/images/168_n.jpg",biography:null,institutionString:null,institution:{name:"Institut Teknologi Bandung",country:{name:"Indonesia"}}},{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRglaQAC/Profile_Picture_1626411846553",biography:"Hiroshi Ishiguro is an award-winning roboticist and innovator. As the Director of the Intelligent Robotics Laboratory, which is part of the Department of Systems Innovation in the Graduate School of Engineering Science at Osaka University, Japan, Ishiguro concentrates on making robots that are similar as possible to humans to understand the human species. A notable project of his laboratory is the Actroid, a humanoid robot with a lifelike appearance and observable behavior such as facial movements. (Sources: http://www.geminoid.jp/en/index.html, https://en.wikipedia.org/wiki/Hiroshi_Ishiguro)",institutionString:null,institution:{name:"Osaka University",country:{name:"Japan"}}},{id:"45747",title:"Dr.",name:"Hsin-I",middleName:null,surname:"Chang",slug:"hsin-i-chang",fullName:"Hsin-I Chang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Chiayi University",country:{name:"Taiwan"}}},{id:"61581",title:"Dr.",name:"Joy Rizki Pangestu",middleName:null,surname:"Djuansjah",slug:"joy-rizki-pangestu-djuansjah",fullName:"Joy Rizki Pangestu Djuansjah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61581/images/237_n.jpg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"94249",title:"Prof.",name:"Junji",middleName:null,surname:"Kido",slug:"junji-kido",fullName:"Junji Kido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Yamagata University",country:{name:"Japan"}}},{id:"12009",title:"Dr.",name:"Ki Young",middleName:null,surname:"Kim",slug:"ki-young-kim",fullName:"Ki Young Kim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12009/images/system/12009.jpg",biography:"Http://m80.knu.ac.kr/~doors",institutionString:null,institution:{name:"National Cheng Kung University",country:{name:"Taiwan"}}},{id:"132595",title:"Prof.",name:"Long",middleName:null,surname:"Wang",slug:"long-wang",fullName:"Long Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Peking University",country:{name:"China"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6675},{group:"region",caption:"Middle and South America",value:2,count:5955},{group:"region",caption:"Africa",value:3,count:2458},{group:"region",caption:"Asia",value:4,count:12717},{group:"region",caption:"Australia and Oceania",value:5,count:1017},{group:"region",caption:"Europe",value:6,count:17720}],offset:12,limit:12,total:12718},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{topicId:"12"},books:[{type:"book",id:"10845",title:"Marine Ecosystems - Biodiversity, Ecosystem Services and Human Impacts",subtitle:null,isOpenForSubmission:!0,hash:"727e7eb3d4ba529ec5eb4f150e078523",slug:null,bookSignature:"Dr. Ana M.M. Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10845.jpg",editedByType:null,editors:[{id:"320124",title:"Dr.",name:"Ana M.M.",surname:"Gonçalves",slug:"ana-m.m.-goncalves",fullName:"Ana M.M. Gonçalves"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11450",title:"Environmental Impacts of COVID-19 Pandemic on the World",subtitle:null,isOpenForSubmission:!0,hash:"a58c7b02d07903004be70f744f2e1835",slug:null,bookSignature:"Prof. Mohamed Nageeb Rashed and Prof. Wafaa M. Abd El-Rahim",coverURL:"https://cdn.intechopen.com/books/images_new/11450.jpg",editedByType:null,editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11457",title:"Forest Degradation Under Global Change",subtitle:null,isOpenForSubmission:!0,hash:"8df7150b01ae754024c65d1a62f190d9",slug:null,bookSignature:"Dr. Pavel Samec",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",editedByType:null,editors:[{id:"317087",title:"Dr.",name:"Pavel",surname:"Samec",slug:"pavel-samec",fullName:"Pavel Samec"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11650",title:"Aquifers - New Insights",subtitle:null,isOpenForSubmission:!0,hash:"27c1a2a053cb1d83de903c5b969bc3a2",slug:null,bookSignature:"Dr. Abhay Soni and Dr. Prabhat Jain",coverURL:"https://cdn.intechopen.com/books/images_new/11650.jpg",editedByType:null,editors:[{id:"271093",title:"Dr.",name:"Abhay",surname:"Soni",slug:"abhay-soni",fullName:"Abhay Soni"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11664",title:"Recent Advances in Sensing Technologies for Environmental Control and Monitoring",subtitle:null,isOpenForSubmission:!0,hash:"cf1ee76443e393bc7597723c3ee3e26f",slug:null,bookSignature:"Dr. Toonika Rinken and Dr. Kairi Kivirand",coverURL:"https://cdn.intechopen.com/books/images_new/11664.jpg",editedByType:null,editors:[{id:"24687",title:"Dr.",name:"Toonika",surname:"Rinken",slug:"toonika-rinken",fullName:"Toonika Rinken"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11665",title:"Recent Advances in Wildlife Management",subtitle:null,isOpenForSubmission:!0,hash:"73da0df494a1a56ab9c4faf2ee811899",slug:null,bookSignature:"Dr. Farzana Khan Perveen",coverURL:"https://cdn.intechopen.com/books/images_new/11665.jpg",editedByType:null,editors:[{id:"75563",title:"Dr.",name:"Farzana Khan",surname:"Perveen",slug:"farzana-khan-perveen",fullName:"Farzana Khan Perveen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11666",title:"Soil Contamination - Recent Advances and Future Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"c8890038b86fb6e5af16ea3c22669ae9",slug:null,bookSignature:"Dr. Adnan Mustafa and Dr. Muhammad Naveed",coverURL:"https://cdn.intechopen.com/books/images_new/11666.jpg",editedByType:null,editors:[{id:"299110",title:"Dr.",name:"Adnan",surname:"Mustafa",slug:"adnan-mustafa",fullName:"Adnan Mustafa"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11668",title:"Mercury Pollution",subtitle:null,isOpenForSubmission:!0,hash:"0bd111f57835089cad4a9741326dbab7",slug:null,bookSignature:"Dr. Ahmed Abdelhafez and Dr. Mohamed Abbas",coverURL:"https://cdn.intechopen.com/books/images_new/11668.jpg",editedByType:null,editors:[{id:"196849",title:"Dr.",name:"Ahmed",surname:"Abdelhafez",slug:"ahmed-abdelhafez",fullName:"Ahmed Abdelhafez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12130",title:"Sustainable Built Environment",subtitle:null,isOpenForSubmission:!0,hash:"ed1dbae71b967e06efb049208f0c1068",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12130.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12131",title:"Climate Change and Fires",subtitle:null,isOpenForSubmission:!0,hash:"ea0858f07a3e87aaf9e5eaa75b4b44bd",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12131.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12180",title:"Wetlands",subtitle:null,isOpenForSubmission:!0,hash:"8957c5c2baaed32223f911a6d4aa5a03",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12180.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12221",title:"Air Pollution",subtitle:null,isOpenForSubmission:!0,hash:"439a018ee0c4960560cb798601f2a372",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12221.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:38},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:13},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:24},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:65},{group:"topic",caption:"Environmental Sciences",value:12,count:10},{group:"topic",caption:"Immunology and Microbiology",value:13,count:16},{group:"topic",caption:"Materials Science",value:14,count:25},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:116},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:6},{group:"topic",caption:"Neuroscience",value:18,count:4},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:9},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:15},popularBooks:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4431},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11043",title:"Endometriosis",subtitle:"Recent Advances, New Perspectives and Treatments",isOpenForSubmission:!1,hash:"7baf1c70b11d41400bb9302ae9411ca4",slug:"endometriosis-recent-advances-new-perspectives-and-treatments",bookSignature:"Giovana Ap. Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11043.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"185930",title:"Associate Prof.",name:"Giovana",middleName:null,surname:"Gonçalves",slug:"giovana-goncalves",fullName:"Giovana Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!1,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:"campylobacter",bookSignature:"Guillermo Tellez-Isaias and Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",isOpenForSubmission:!1,hash:"f197f6062c1574a9a90e50a369271bcf",slug:"starch-evolution-and-recent-advances",bookSignature:"Martins Ochubiojo Emeje",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11083",title:"Hazardous Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"d553bd4f6f1c4b115ca69bd19faac7dc",slug:"hazardous-waste-management",bookSignature:"Rajesh Banu Jeyakumar, Kavitha Sankarapandian and Yukesh Kannah Ravi",coverURL:"https://cdn.intechopen.com/books/images_new/11083.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10848",title:"Tribology of Machine Elements",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"3c4ca4c4692ca8d4fa749b4ae81ec1fa",slug:"tribology-of-machine-elements-fundamentals-and-applications",bookSignature:"Giuseppe Pintaude, Tiago Cousseau and Anna Rudawska",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"18347",title:"Prof.",name:"Giuseppe",middleName:null,surname:"Pintaude",slug:"giuseppe-pintaude",fullName:"Giuseppe Pintaude"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10856",title:"Crude Oil",subtitle:"New Technologies and Recent Approaches",isOpenForSubmission:!1,hash:"8d0a7ca35b3de95b295dc4eab39a087e",slug:"crude-oil-new-technologies-and-recent-approaches",bookSignature:"Manar Elsayed Abdel-Raouf and Mohamed Hasan El-Keshawy",coverURL:"https://cdn.intechopen.com/books/images_new/10856.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"102626",title:"Prof.",name:"Manar",middleName:null,surname:"Elsayed Abdel-Raouf",slug:"manar-elsayed-abdel-raouf",fullName:"Manar Elsayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9625",title:"Spinocerebellar Ataxia",subtitle:"Concepts, Particularities and Generalities",isOpenForSubmission:!1,hash:"365a7025fd46eb45de2549bdd9d50b98",slug:"spinocerebellar-ataxia-concepts-particularities-and-generalities",bookSignature:"Patricia Bozzetto Ambrosi",coverURL:"https://cdn.intechopen.com/books/images_new/9625.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"221787",title:"Dr.",name:"Patricia",middleName:null,surname:"Bozzetto Ambrosi",slug:"patricia-bozzetto-ambrosi",fullName:"Patricia Bozzetto Ambrosi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10905",title:"Plant Defense Mechanisms",subtitle:null,isOpenForSubmission:!1,hash:"84ad5b27dde5f01dc76087d0fd6fa834",slug:"plant-defense-mechanisms",bookSignature:"Josphert Ngui Kimatu",coverURL:"https://cdn.intechopen.com/books/images_new/10905.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"224171",title:"Prof.",name:"Josphert N.",middleName:null,surname:"Kimatu",slug:"josphert-n.-kimatu",fullName:"Josphert N. Kimatu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10686",title:"Natural Gas",subtitle:"New Perspectives and Future Developments",isOpenForSubmission:!1,hash:"581763788a6a59e653a9d1d9b5a42d79",slug:"natural-gas-new-perspectives-and-future-developments",bookSignature:"Maryam Takht Ravanchi",coverURL:"https://cdn.intechopen.com/books/images_new/10686.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"2416",title:"Dr.",name:"Maryam",middleName:null,surname:"Takht Ravanchi",slug:"maryam-takht-ravanchi",fullName:"Maryam Takht Ravanchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10988",title:"Railway Transport Planning and Manageme",subtitle:null,isOpenForSubmission:!1,hash:"5cb54cc53caedad9ec78372563c82e2c",slug:"railway-transport-planning-and-management",bookSignature:"Stefano de Luca, Roberta Di Pace and Chiara Fiori",coverURL:"https://cdn.intechopen.com/books/images_new/10988.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"4",title:"Social Sciences and Humanities",slug:"social-sciences-and-humanities",parent:null,numberOfBooks:297,numberOfSeries:3,numberOfAuthorsAndEditors:5391,numberOfWosCitations:2993,numberOfCrossrefCitations:3111,numberOfDimensionsCitations:5701,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"4",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editedByType:"Edited by",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editedByType:"Edited by",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11258",title:"Innovation, Research and Development and Capital Evaluation",subtitle:null,isOpenForSubmission:!1,hash:"a644b267db0cddd8a16f0dfadf03bad6",slug:"innovation-research-and-development-and-capital-evaluation",bookSignature:"Luigi Aldieri",coverURL:"https://cdn.intechopen.com/books/images_new/11258.jpg",editedByType:"Edited by",editors:[{id:"246585",title:"Prof.",name:"Luigi",middleName:null,surname:"Aldieri",slug:"luigi-aldieri",fullName:"Luigi Aldieri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editedByType:"Edited by",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10889",title:"Aphasia Compendium",subtitle:null,isOpenForSubmission:!1,hash:"f2c0b1c302f68d0c86ae8e057d1cc90e",slug:"aphasia-compendium",bookSignature:"Dragoș Cătălin Jianu and Dafin Fior Mureșanu",coverURL:"https://cdn.intechopen.com/books/images_new/10889.jpg",editedByType:"Edited by",editors:[{id:"45925",title:"Prof.",name:"Dragoș",middleName:null,surname:"Cătălin Jianu",slug:"dragos-catalin-jianu",fullName:"Dragoș Cătălin Jianu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11004",title:"Medical Education for the 21st Century",subtitle:null,isOpenForSubmission:!1,hash:"f8863875cdefa578f26a438ea21bdc1e",slug:"medical-education-for-the-21st-century",bookSignature:"Michael S. Firstenberg and Stanislaw P. Stawicki",coverURL:"https://cdn.intechopen.com/books/images_new/11004.jpg",editedByType:"Edited by",editors:[{id:"64343",title:"Dr.",name:"Michael S.",middleName:null,surname:"Firstenberg",slug:"michael-s.-firstenberg",fullName:"Michael S. Firstenberg"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10207",title:"Sexual Abuse",subtitle:"An Interdisciplinary Approach",isOpenForSubmission:!1,hash:"e1ec1d5a7093490df314d7887e0b3809",slug:"sexual-abuse-an-interdisciplinary-approach",bookSignature:"Ersi Kalfoğlu and Sotirios Kalfoglou",coverURL:"https://cdn.intechopen.com/books/images_new/10207.jpg",editedByType:"Edited by",editors:[{id:"68678",title:"Dr.",name:"Ersi",middleName:null,surname:"Kalfoglou",slug:"ersi-kalfoglou",fullName:"Ersi Kalfoglou"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10914",title:"Effective Elimination of Structural Racism",subtitle:null,isOpenForSubmission:!1,hash:"f6a2562646c0fd664aca8335bc3b3e69",slug:"effective-elimination-of-structural-racism",bookSignature:"Erick Guerrero",coverURL:"https://cdn.intechopen.com/books/images_new/10914.jpg",editedByType:"Edited by",editors:[{id:"294761",title:"Dr.",name:"Erick",middleName:null,surname:"Guerrero",slug:"erick-guerrero",fullName:"Erick Guerrero"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10915",title:"Leadership",subtitle:"New Insights",isOpenForSubmission:!1,hash:"0d72e79892f2a020cee66a52d09de5a4",slug:"leadership-new-insights",bookSignature:"Mário Franco",coverURL:"https://cdn.intechopen.com/books/images_new/10915.jpg",editedByType:"Edited by",editors:[{id:"105529",title:"Dr.",name:"Mário",middleName:null,surname:"Franco",slug:"mario-franco",fullName:"Mário Franco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",isOpenForSubmission:!1,hash:"86a6d33cf601587e591064ce92effc02",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",editedByType:"Edited by",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:297,seriesByTopicCollection:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],seriesByTopicTotal:3,mostCitedChapters:[{id:"42656",doi:"10.5772/55538",title:"Conceptual Frameworks of Vulnerability Assessments for Natural Disasters Reduction",slug:"conceptual-frameworks-of-vulnerability-assessments-for-natural-disasters-reduction",totalDownloads:9976,totalCrossrefCites:18,totalDimensionsCites:75,abstract:null,book:{id:"3054",slug:"approaches-to-disaster-management-examining-the-implications-of-hazards-emergencies-and-disasters",title:"Approaches to Disaster Management",fullTitle:"Approaches to Disaster Management - Examining the Implications of Hazards, Emergencies and Disasters"},signatures:"Roxana L. Ciurean, Dagmar Schröter and Thomas Glade",authors:[{id:"163703",title:"Prof.",name:"Thomas",middleName:null,surname:"Glade",slug:"thomas-glade",fullName:"Thomas Glade"},{id:"164141",title:"Ph.D. Student",name:"Roxana",middleName:"Liliana",surname:"Ciurean",slug:"roxana-ciurean",fullName:"Roxana Ciurean"},{id:"164142",title:"Dr.",name:"Dagmar",middleName:null,surname:"Schroeter",slug:"dagmar-schroeter",fullName:"Dagmar Schroeter"}]},{id:"58010",doi:"10.5772/intechopen.72304",title:"Fourth Industrial Revolution: Current Practices, Challenges, and Opportunities",slug:"fourth-industrial-revolution-current-practices-challenges-and-opportunities",totalDownloads:6371,totalCrossrefCites:42,totalDimensionsCites:68,abstract:"The globalization and the competitiveness are forcing companies to rethink and to innovate their production processes following the so-called Industry 4.0 paradigm. It represents the integration of tools already used in the past (big data, cloud, robot, 3D printing, simulation, etc.) that are now connected into a global network by transmitting digital data. The implementation of this new paradigm represents a huge change for companies, which are faced with big investments. In order to benefit from the opportunities offered by the smart revolution, companies must have the prerequisites needed to withstand changes generated by “smart” system. In addition, new workers who face the world of work 4.0 must have new skills in automation, digitization, and information technology, without forgetting soft skills. This chapter aims to present the main good practices, challenges, and opportunities related to Industry 4.0 paradigm.",book:{id:"6291",slug:"digital-transformation-in-smart-manufacturing",title:"Digital Transformation in Smart Manufacturing",fullTitle:"Digital Transformation in Smart Manufacturing"},signatures:"Antonella Petrillo, Fabio De Felice, Raffaele Cioffi and Federico\nZomparelli",authors:[{id:"161682",title:"Prof.",name:"Fabio",middleName:null,surname:"De Felice",slug:"fabio-de-felice",fullName:"Fabio De Felice"},{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo"},{id:"205141",title:"Dr.",name:"Federico",middleName:null,surname:"Zomparelli",slug:"federico-zomparelli",fullName:"Federico Zomparelli"},{id:"208748",title:"Dr.",name:"Raffaele",middleName:null,surname:"Cioffi",slug:"raffaele-cioffi",fullName:"Raffaele Cioffi"}]},{id:"40977",doi:"10.5772/53885",title:"The Emergence of Scientific Reasoning",slug:"the-emergence-of-scientific-reasoning",totalDownloads:4520,totalCrossrefCites:8,totalDimensionsCites:58,abstract:null,book:{id:"654",slug:"current-topics-in-children-s-learning-and-cognition",title:"Current Topics in Children's Learning and Cognition",fullTitle:"Current Topics in Children's Learning and Cognition"},signatures:"Bradley J. Morris, Steve Croker, Amy M. Masnick and Corinne Zimmerman",authors:[{id:"154336",title:"Prof.",name:"Bradley",middleName:null,surname:"Morris",slug:"bradley-morris",fullName:"Bradley Morris"},{id:"154337",title:"Prof.",name:"Steve",middleName:null,surname:"Croker",slug:"steve-croker",fullName:"Steve Croker"},{id:"154338",title:"Prof.",name:"Amy",middleName:null,surname:"Masnick",slug:"amy-masnick",fullName:"Amy Masnick"},{id:"154339",title:"Prof.",name:"Corinne",middleName:null,surname:"Zimmerman",slug:"corinne-zimmerman",fullName:"Corinne Zimmerman"}]},{id:"35715",doi:"10.5772/38693",title:"The Role and Importance of Cultural Tourism in Modern Tourism Industry",slug:"the-role-and-importance-of-cultural-tourism-in-modern-tourism-industry",totalDownloads:41056,totalCrossrefCites:30,totalDimensionsCites:57,abstract:null,book:{id:"2298",slug:"strategies-for-tourism-industry-micro-and-macro-perspectives",title:"Strategies for Tourism Industry",fullTitle:"Strategies for Tourism Industry - Micro and Macro Perspectives"},signatures:"Janos Csapo",authors:[{id:"118766",title:"Dr.",name:"János",middleName:null,surname:"Csapó",slug:"janos-csapo",fullName:"János Csapó"}]},{id:"37707",doi:"10.5772/51110",title:"Principle of Meat Aroma Flavors and Future Prospect",slug:"principle-of-meat-aroma-flavors-and-future-prospect",totalDownloads:7443,totalCrossrefCites:17,totalDimensionsCites:52,abstract:null,book:{id:"3276",slug:"latest-research-into-quality-control",title:"Latest Research into Quality Control",fullTitle:"Latest Research into Quality Control"},signatures:"Hoa Van Ba, Inho Hwang, Dawoon Jeong and Amna Touseef",authors:[{id:"153361",title:"Ph.D.",name:"Hoa",middleName:null,surname:"Van Ba",slug:"hoa-van-ba",fullName:"Hoa Van Ba"},{id:"163181",title:"Prof.",name:"Touseef",middleName:null,surname:"Amna",slug:"touseef-amna",fullName:"Touseef Amna"}]}],mostDownloadedChaptersLast30Days:[{id:"58890",title:"Philosophy and Paradigm of Scientific Research",slug:"philosophy-and-paradigm-of-scientific-research",totalDownloads:13759,totalCrossrefCites:9,totalDimensionsCites:17,abstract:"Before carrying out the empirical analysis of the role of management culture in corporate social responsibility, identification of the philosophical approach and the paradigm on which the research carried out is based is necessary. Therefore, this chapter deals with the philosophical systems and paradigms of scientific research, the epistemology, evaluating understanding and application of various theories and practices used in the scientific research. The key components of the scientific research paradigm are highlighted. Theories on the basis of which this research was focused on identification of the level of development of the management culture in order to implement corporate social responsibility are identified, and the stages of its implementation are described.",book:{id:"5791",slug:"management-culture-and-corporate-social-responsibility",title:"Management Culture and Corporate Social Responsibility",fullTitle:"Management Culture and Corporate Social Responsibility"},signatures:"Pranas Žukauskas, Jolita Vveinhardt and Regina Andriukaitienė",authors:[{id:"179629",title:"Prof.",name:"Jolita",middleName:null,surname:"Vveinhardt",slug:"jolita-vveinhardt",fullName:"Jolita Vveinhardt"}]},{id:"74550",title:"School Conflicts: Causes and Management Strategies in Classroom Relationships",slug:"school-conflicts-causes-and-management-strategies-in-classroom-relationships",totalDownloads:2204,totalCrossrefCites:1,totalDimensionsCites:10,abstract:"Conflicts cannot cease to exist, as they are intrinsic to human beings, forming an integral part of their moral and emotional growth. Likewise, they exist in all schools. The school is inserted in a space where the conflict manifests itself daily and assumes relevance, being the result of the multiple interpersonal relationships that occur in the school context. Thus, conflict is part of school life, which implies that teachers must have the skills to manage conflict constructively. Recognizing the diversity of school conflicts, this chapter aimed to present its causes, highlighting the main ones in the classroom, in the teacher-student relationship. It is important to conflict face and resolve it with skills to manage it properly and constructively, establishing cooperative relationships, and producing integrative solutions. Harmony and appreciation should coexist in a classroom environment and conflict should not interfere, negatively, in the teaching and learning process. This bibliography review underscore the need for during the teachers’ initial training the conflict management skills development.",book:{id:"7827",slug:null,title:"Interpersonal Relationships",fullTitle:"Interpersonal Relationships"},signatures:"Sabina Valente, Abílio Afonso Lourenço and Zsolt Németh",authors:null},{id:"58969",title:"Corruption, Causes and Consequences",slug:"corruption-causes-and-consequences",totalDownloads:27589,totalCrossrefCites:11,totalDimensionsCites:13,abstract:"Corruption is a constant in the society and occurs in all civilizations; however, it has only been in the past 20 years that this phenomenon has begun being seriously explored. It has many different shapes as well as many various effects, both on the economy and the society at large. Among the most common causes of corruption are the political and economic environment, professional ethics and morality and, of course, habits, customs, tradition and demography. Its effects on the economy (and also on the wider society) are well researched, yet still not completely. Corruption thus inhibits economic growth and affects business operations, employment and investments. It also reduces tax revenue and the effectiveness of various financial assistance programs. The wider society is influenced by a high degree of corruption in terms of lowering of trust in the law and the rule of law, education and consequently the quality of life (access to infrastructure, health care). There also does not exist an unambiguous answer as to how to deal with corruption. Something that works in one country or in one region will not necessarily be successful in another. This chapter tries to answer at least a few questions about corruption and the causes for it, its consequences and how to deal with it successfully.",book:{id:"6487",slug:"trade-and-global-market",title:"Trade and Global Market",fullTitle:"Trade and Global Market"},signatures:"Štefan Šumah",authors:[{id:"228073",title:"Mr.",name:"Stefan",middleName:null,surname:"Sumah",slug:"stefan-sumah",fullName:"Stefan Sumah"}]},{id:"55499",title:"Human Resources Management in Nonprofit Organizations: A Case Study of Istanbul Foundation for Culture and Arts",slug:"human-resources-management-in-nonprofit-organizations-a-case-study-of-istanbul-foundation-for-cultur",totalDownloads:2294,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The aim of this study is to investigate the efficiency and importance of human resources management in nonprofit organizations. The understanding was included to the literature as personnel management at the beginning of the twentieth century and it turned into an approach as human resources management in the 1980s. It could be observed that many organizations, which deem the human as the most critical stakeholder, adopt a traditional way of personnel management in operating human resources. The employees play a key role in the success of an organization. For this reason, subjects such as recruitment, training, development, career management, performance appraisal, occupational health, and safety are the fundamental functions of human resources management. The study examines to what extent these roles are evaluated through a case study. The subject matter of the study is the most powerful culture and art foundation in Turkey. Compared to many other nonprofit organizations, the foundation actively performs a variety of services within a year worldwide. The fact that the total number of employees might rise up to 800, including the field personnel, indicates the need of a good functioning human resources management. The human resources practices of the foundation are examined and evaluated within that scope.",book:{id:"5826",slug:"issues-of-human-resource-management",title:"Issues of Human Resource Management",fullTitle:"Issues of Human Resource Management"},signatures:"Beste Gökçe Parsehyan",authors:[{id:"189113",title:"Dr.",name:"Beste",middleName:null,surname:"Gokce Parsehyan",slug:"beste-gokce-parsehyan",fullName:"Beste Gokce Parsehyan"}]},{id:"59152",title:"Marketing Strategies for the Social Good",slug:"marketing-strategies-for-the-social-good",totalDownloads:1594,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Social network sites (SNS) have proven to be a good environment to promote and sell goods and services, but marketing is more than creating commercial strategies. Social marketing strategies can also be used to promote behavioral change and help individuals transform their lives, achieve well-being, and adopt prosocial behaviors. In this chapter, we seek to analyze with a netnographic study, how SNS are being employed by nonprofits and nongovernment organizations (NGOs) to enable citizens and consumers to participate in different programs and activities that promote social transformation and well-being. A particular interest is to identify how organizations are using behavioral economic tactics to nudge individuals and motivate them to engage in prosocial actions. By providing an understanding on how SNS can provide an adequate environment for the design of social marketing strategies, we believe our work has practical implications both for academicians and marketers who want to contribute in the transformation of consumer behavior and the achievement of well-being and social change.",book:{id:"6583",slug:"marketing",title:"Marketing",fullTitle:"Marketing"},signatures:"Alicia De La Pena",authors:[{id:"196878",title:"Dr.",name:"Alicia",middleName:null,surname:"De La Pena",slug:"alicia-de-la-pena",fullName:"Alicia De La Pena"}]}],onlineFirstChaptersFilter:{topicId:"4",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82382",title:"A Cultural Approach in the Synchronous Class in English Teaching and Learning",slug:"a-cultural-approach-in-the-synchronous-class-in-english-teaching-and-learning",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.105553",abstract:"If culture is defined as a way of training to obtain knowledge through educational channels, the concept is associated with educability. Therefore, teaching cognitive, attitudinal, and procedural knowledge directly indicates teaching and learning culture to acquire norms and patterns of sociocultural behavior. The purpose of this study was: to debate about the way interaction among students and teachers in synchronous classes based on life’s materials, topics, and methods, and critical or reflective thinking can be adapted by the teacher to the students’ closest environment to communicate in English as an international language. If a language is taught, spoken, and learned in the country, culture surrounding the context is taught. If this language is not spoken in the place, the knowledge system also transmits norms and values, different from those of the language. So, the students get, culturally and socially, modes of action, principles, and knowledge through international language learning. Thus, teaching and learning English as an international language means the way possible interaction has opportunities for every student’s growth and the way their personality formation gets integral results. English taught and learned as an international language denotes reaching the students’ world and needs to communicate in English as a meaningful international language.",book:{id:"10662",title:"Pedagogy - Challenges, Recent Advances, New Perspectives, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10662.jpg"},signatures:"Ned Vito Quevedo Arnaiz, Nemis García Arias and Fredy Pablo Cañizares Galarza"},{id:"82470",title:"The Effect of COVID-19 on the Quality of Life of Care Workers: Challenges for Social Services Leaders",slug:"the-effect-of-covid-19-on-the-quality-of-life-of-care-workers-challenges-for-social-services-leaders",totalDownloads:1,totalDimensionsCites:null,doi:"10.5772/intechopen.105603",abstract:"Stressful situations are likely to impact health and social care workers’ quality of life negatively. Indeed, mental, physical, and emotional health problems have been reported in relation to the effects of the COVID-19 pandemic on the quality of life of health care workers. Instead of health care workers’ reality, and despite the care sector’s relevance, studies of the effects of COVID-19 on the quality of life of care workers have not been sufficiently explored. Recognizing the effect of COVID on the quality of life of care workers will collaborate with leaders of organizations, social work practitioners, and academics in the design of policies that promote better working conditions. Therefore, during 2021, a study was carried out in Chile where 150 social services and care workers were surveyed in Chile using a version of COV19-QoL in Spanish. The impact of COVID on quality of life is described, and the challenges that this reality implies to social service leaders are presented.",book:{id:"11095",title:"Social Work - Perspectives on Leadership and Organisation",coverURL:"https://cdn.intechopen.com/books/images_new/11095.jpg"},signatures:"Magdalena Calderón-Orellana, Alejandra Inostroza and Paula Miranda Sánchez"},{id:"82448",title:"Virus World Vulnerability: A Critical Reading of Gender and Performance in Bo Burnham’s “Inside” (2021)",slug:"virus-world-vulnerability-a-critical-reading-of-gender-and-performance-in-bo-burnham-s-inside-2021",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105182",abstract:"Through an engagement with the seminal work of Raewyn Connell on masculinities and hegemonic masculinity, this chapter argues for the hegemonic norm as producing behaviour among men that can be traced in multiple male subjectivities. The argument is that men respond to the prevailing masculine norm by enacting self-protective disavowal—a complex psychological process that involves the reordering of reality in the interests of the maintenance of power, and one that is seen in cases of both legitimate and imagined threats to the self and the body. Self-protective disavowal is at the core of the Same Shit phenomenon—the idea that while the experience of masculinity varies across culture and position in the gender order, self-protective disavowal is a constant that leads to predicable patterns among men. The discussion then explores deliberate vulnerability as a kind of anti-protective disavowal in Bo Burnham’s INSIDE, a complex, undefinable ‘special’ released on Netflix in 2021. The chapter considers Burnham’s work as a departure from self-protective disavowal and Same Shit masculinity through deliberate vulnerability and critically evaluates the value of this alternative, especially given the nihilism that reigns over the work and calls into question the validity of uncritically romanticization of alternatives.",book:{id:"10540",title:"Masculinity Studies - An Interdisciplinary Approach",coverURL:"https://cdn.intechopen.com/books/images_new/10540.jpg"},signatures:"Chris McWade"},{id:"82454",title:"Prospects and Pitfalls Experienced by Social Workers Working in a Confounding Environment in a South African Setting",slug:"prospects-and-pitfalls-experienced-by-social-workers-working-in-a-confounding-environment-in-a-south",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105604",abstract:"While social workers are professionally and aptly placed to facilitate a turn-around environment rife with a conglomeration of challenges such as poverty, ignorance, and diseases, the chapter discusses the developmental prospects and pitfalls that confound their practice in South Africa. Opportunely, social work interventions continue to gain developmental mileage through increased training of social workers, their increased deployment in various versatile domains of social and economic development and increased widening of the scope of social work research, especially current research in fields such as HIV/AIDS and coronavirus. On the other side of the coin, the chapter discusses social work pitfalls attributed to professional curricular gaps as social work continue to follow a western-centric curriculum; the presence of various metaphysical beliefs and myths that weaken or derail social work interventions and a weaker research environment to offer a plausible and timely solution to the prevalent problems. The chapter concludes by calling for a paradigm shift in the social work curriculum as well as its indigenization to productively respond to the South African socio-cultural and geographical milieu.",book:{id:"11095",title:"Social Work - Perspectives on Leadership and Organisation",coverURL:"https://cdn.intechopen.com/books/images_new/11095.jpg"},signatures:"Simon Murote Kang’ethe"},{id:"82425",title:"Financial Reporting and Analysis of Tesla Green Technology in the United States Market",slug:"financial-reporting-and-analysis-of-tesla-green-technology-in-the-united-states-market",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105065",abstract:"This study aims to discuss and analyze the financial position and performance of the US Tesla green technology company in the United States. This study uses a case study approach, financial data, and website methodologies to collect and analyze the research data. The case study is Tesla, Inc., which is a US electric vehicle and clean energy company based in Austin, Texas. Tesla is a green technology company that produces and designs electric cars, battery energy storage from home to grid-scale, solar roof tiles and solar panels, and related products and services. Tesla is growing fastly by introducing new green products, and it is now one of the world’s most valuable enterprises. It has a high market capitalization of almost US$1 trillion to become the world’s most valuable automaker. This study concludes that Tesla has changed their strategy to become the most worldwide sales of purely battery electric vehicles, capturing 23% of the market and 16% of the plug-in electric battery in the market for 2020. It has also developed a significant installer of photovoltaic systems through its subsidiary Tesla Energy in the United States. One of the largest global battery energy-storage systems suppliers is Tesla Energy, with 3.99 gigawatt-hours installed in 2021.",book:{id:"11251",title:"Banking and Accounting",coverURL:"https://cdn.intechopen.com/books/images_new/11251.jpg"},signatures:"Nizar Mohammad Alsharari"},{id:"82427",title:"Our Globalization Era among Success, Obstacles and Doubts",slug:"our-globalization-era-among-success-obstacles-and-doubts",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.105545",abstract:"In the last decades, the never-ending and unlimited expanding of both international economies and operations became globalization. Among its main features, one could recall the enormous increase of world macro-economic quantities (Gross World Product, Inter-continental Trade, FDI), as well as financial values (public debts and currency printing). The chapter tries to quantify them, by a statistical analysis of historical data (Section 1). Section 2 is dedicated to the strategic problems of firms, in particular the threats and opportunities for (inter) national firms willing to become global, and obstacles are included in Section 3. This given, it deals with the behavior of countries from the political and juridical points of view, and those ones passed form initial perplexities, distaste, or even hostility to a favorable behavior. Conclusions (Section 4) recall both the problematic alternative for globalized companies between “the world as our next door” and their social responsibilities and the similar problem for host countries, between socioeconomic advantages and protection of local workers, resources, and environment.",book:{id:"11476",title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg"},signatures:"Arnaldo Canziani, Annalisa Baldissera and Ahmad Kahwaji"}],onlineFirstChaptersTotal:282},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"June 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. He has served as guest editor for a number of special issues of peer-reviewed international journals.",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:19,paginationItems:[{id:"82196",title:"Multi-Features Assisted Age Invariant Face Recognition and Retrieval Using CNN with Scale Invariant Heat Kernel Signature",doi:"10.5772/intechopen.104944",signatures:"Kamarajugadda Kishore Kumar and Movva Pavani",slug:"multi-features-assisted-age-invariant-face-recognition-and-retrieval-using-cnn-with-scale-invariant-",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"82063",title:"Evaluating Similarities and Differences between Machine Learning and Traditional Statistical Modeling in Healthcare Analytics",doi:"10.5772/intechopen.105116",signatures:"Michele Bennett, Ewa J. Kleczyk, Karin Hayes and Rajesh Mehta",slug:"evaluating-similarities-and-differences-between-machine-learning-and-traditional-statistical-modelin",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Machine Learning and Data Mining - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11422.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81791",title:"Self-Supervised Contrastive Representation Learning in Computer Vision",doi:"10.5772/intechopen.104785",signatures:"Yalin Bastanlar and Semih Orhan",slug:"self-supervised-contrastive-representation-learning-in-computer-vision",totalDownloads:28,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"79345",title:"Application of Jump Diffusion Models in Insurance Claim Estimation",doi:"10.5772/intechopen.99853",signatures:"Leonard Mushunje, Chiedza Elvina Mashiri, Edina Chandiwana and Maxwell Mashasha",slug:"application-of-jump-diffusion-models-in-insurance-claim-estimation-1",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}}]},overviewPagePublishedBooks:{paginationCount:9,paginationItems:[{type:"book",id:"7723",title:"Artificial Intelligence",subtitle:"Applications in Medicine and Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7723.jpg",slug:"artificial-intelligence-applications-in-medicine-and-biology",publishedDate:"July 31st 2019",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"a3852659e727f95c98c740ed98146011",volumeInSeries:1,fullTitle:"Artificial Intelligence - Applications in Medicine and Biology",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]},{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - Recent Advances, New Perspectives and Applications",editors:[{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null}]},{type:"book",id:"7656",title:"Fuzzy Logic",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7656.jpg",slug:"fuzzy-logic",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Constantin Volosencu",hash:"54f092d4ffe0abf5e4172a80025019bc",volumeInSeries:3,fullTitle:"Fuzzy Logic",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",institutionURL:null,country:{name:"Romania"}}}]},{type:"book",id:"9963",title:"Advances and Applications in Deep Learning",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9963.jpg",slug:"advances-and-applications-in-deep-learning",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"0d51ba46f22e55cb89140f60d86a071e",volumeInSeries:4,fullTitle:"Advances and Applications in Deep Learning",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]}]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11478",title:"Recent Advances in the Study of Dyslexia",coverURL:"https://cdn.intechopen.com/books/images_new/11478.jpg",hash:"26764a18c6b776698823e0e1c3022d2f",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 30th 2022",isOpenForSubmission:!0,editors:[{id:"294281",title:"Prof.",name:"Jonathan",surname:"Glazzard",slug:"jonathan-glazzard",fullName:"Jonathan Glazzard"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:45,paginationItems:[{id:"82135",title:"Carotenoids in Cassava (Manihot esculenta Crantz)",doi:"10.5772/intechopen.105210",signatures:"Lovina I. Udoh, Josephine U. Agogbua, Eberechi R. Keyagha and Itorobong I. Nkanga",slug:"carotenoids-in-cassava-manihot-esculenta-crantz",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}},{id:"82112",title:"Comparative Senescence and Lifespan",doi:"10.5772/intechopen.105137",signatures:"Hassan M. Heshmati",slug:"comparative-senescence-and-lifespan",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hassan M.",surname:"Heshmati"}],book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:25,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. Drury",slug:"new-and-emerging-technologies-for-integrative-ambulatory-autonomic-assessment-and-intervention-as-a-",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"81576",title:"Carotenoids in Thermal Adaptation of Plants and Animals",doi:"10.5772/intechopen.104537",signatures:"Ivan M. Petyaev",slug:"carotenoids-in-thermal-adaptation-of-plants-and-animals",totalDownloads:24,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Ivan",surname:"Petyaev"}],book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}},{id:"81358",title:"New Insights on Carotenoid Production by Gordonia alkanivorans Strain 1B",doi:"10.5772/intechopen.103919",signatures:"Tiago P. Silva, Susana M. Paixão, Ana S. Fernandes, José C. Roseiro and Luís Alves",slug:"new-insights-on-carotenoid-production-by-gordonia-alkanivorans-strain-1b",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}},{id:"81298",title:"Roles of Extracellular Vesicles in Cancer Metastasis",doi:"10.5772/intechopen.103798",signatures:"Eman Helmy Thabet",slug:"roles-of-extracellular-vesicles-in-cancer-metastasis",totalDownloads:36,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81290",title:"Musculoskeletal Abnormalities Caused by Cystic Fibrosis",doi:"10.5772/intechopen.104591",signatures:"Mark Lambrechts",slug:"musculoskeletal-abnormalities-caused-by-cystic-fibrosis",totalDownloads:24,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Advances in Skeletal Muscle Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11675.jpg",subseries:{id:"11",title:"Cell Physiology"}}}]},subseriesFiltersForOFChapters:[{caption:"Plant Physiology",value:13,count:6,group:"subseries"},{caption:"Human Physiology",value:12,count:13,group:"subseries"},{caption:"Cell Physiology",value:11,count:26,group:"subseries"}],publishedBooks:{paginationCount:32,paginationItems:[{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",slug:"starch-evolution-and-recent-advances",publishedDate:"June 28th 2022",editedByType:"Edited by",bookSignature:"Martins Ochubiojo Emeje",hash:"f197f6062c1574a9a90e50a369271bcf",volumeInSeries:33,fullTitle:"Starch - Evolution and Recent Advances",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",institutionURL:null,country:{name:"Nigeria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",slug:"essential-oils-advances-in-extractions-and-biological-applications",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",hash:"742e6cae3a35686f975edc8d7f9afa94",volumeInSeries:32,fullTitle:"Essential Oils - Advances in Extractions and Biological Applications",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira",profilePictureURL:"https://mts.intechopen.com/storage/users/195290/images/system/195290.png",institutionString:"Museu Paraense Emílio Goeldi",institution:{name:"Museu Paraense Emílio Goeldi",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10839",title:"Protein Detection",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",slug:"protein-detection",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Yusuf Tutar and Lütfi Tutar",hash:"2f1c0e4e0207fc45c936e7d22a5369c4",volumeInSeries:31,fullTitle:"Protein Detection",editors:[{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",institutionString:"University of Health Sciences",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10797",title:"Cell Culture",subtitle:"Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",slug:"cell-culture-advanced-technology-and-applications-in-medical-and-life-sciences",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Xianquan Zhan",hash:"2c628f4757f9639a4450728d839a7842",volumeInSeries:30,fullTitle:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",institutionURL:null,country:{name:"China"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10841",title:"Hydrolases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10841.jpg",slug:"hydrolases",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Sajjad Haider, Adnan Haider and Angel Catalá",hash:"4e868cde273d65a7ff54b1817d640629",volumeInSeries:29,fullTitle:"Hydrolases",editors:[{id:"110708",title:"Dr.",name:"Sajjad",middleName:null,surname:"Haider",slug:"sajjad-haider",fullName:"Sajjad Haider",profilePictureURL:"https://mts.intechopen.com/storage/users/110708/images/system/110708.png",institutionString:"King Saud University",institution:{name:"King Saud University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",slug:"reactive-oxygen-species",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Rizwan Ahmad",hash:"176adcf090fdd1f93cb8ce3146e79ca1",volumeInSeries:28,fullTitle:"Reactive Oxygen Species",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",publishedDate:"March 23rd 2022",editedByType:"Edited by",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",hash:"8b43add5389ba85743e0a9491e4b9943",volumeInSeries:27,fullTitle:"Vitamin K - Recent Topics on the Biology and Chemistry",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10799",title:"Phenolic Compounds",subtitle:"Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10799.jpg",slug:"phenolic-compounds-chemistry-synthesis-diversity-non-conventional-industrial-pharmaceutical-and-therapeutic-applications",publishedDate:"February 23rd 2022",editedByType:"Edited by",bookSignature:"Farid A. Badria",hash:"339199f254d2987ef3167eef74fb8a38",volumeInSeries:26,fullTitle:"Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9659",title:"Fibroblasts",subtitle:"Advances in Inflammation, Autoimmunity and Cancer",coverURL:"https://cdn.intechopen.com/books/images_new/9659.jpg",slug:"fibroblasts-advances-in-inflammation-autoimmunity-and-cancer",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Mojca Frank Bertoncelj and Katja Lakota",hash:"926fa6446f6befbd363fc74971a56de2",volumeInSeries:25,fullTitle:"Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer",editors:[{id:"328755",title:"Ph.D.",name:"Mojca",middleName:null,surname:"Frank Bertoncelj",slug:"mojca-frank-bertoncelj",fullName:"Mojca Frank Bertoncelj",profilePictureURL:"https://mts.intechopen.com/storage/users/328755/images/system/328755.jpg",institutionString:"BioMed X Institute",institution:{name:"University Hospital of Zurich",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:13}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:8},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:229,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"355660",title:"Dr.",name:"Anitha",middleName:null,surname:"Mani",slug:"anitha-mani",fullName:"Anitha Mani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"355612",title:"Dr.",name:"Janani",middleName:null,surname:"Karthikeyan",slug:"janani-karthikeyan",fullName:"Janani Karthikeyan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334400",title:"Dr.",name:"Suvetha",middleName:null,surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}}]}},subseries:{item:{id:"15",type:"subseries",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},onlineFirstChapters:{paginationCount:7,paginationItems:[{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? Empirical Evidence from an Emerging Economy",doi:"10.5772/intechopen.105589",signatures:"Bishnu Kumar Adhikary and Ranjan Kumar Mitra",slug:"does-board-structure-matter-in-csr-spending-of-commercial-banks-empirical-evidence-from-an-emerging-",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82395",title:"Toward a Better Understanding of Green Human Resource Management’s Impact on Green Competitive Advantage: A Conceptual Model",doi:"10.5772/intechopen.105528",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"toward-a-better-understanding-of-green-human-resource-management-s-impact-on-green-competitive-advan",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82269",title:"CSR Reporting and Blockchain Technology",doi:"10.5772/intechopen.105512",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Piyachart Phiromswad",slug:"csr-reporting-and-blockchain-technology",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82270",title:"From Corporate Social Opportunity to Corporate Social Responsibility",doi:"10.5772/intechopen.105445",signatures:"Brian Bolton",slug:"from-corporate-social-opportunity-to-corporate-social-responsibility",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82339",title:"Green Human Resource Management: An Exploratory Study from Moroccan ISO 14001 Certified Companies",doi:"10.5772/intechopen.105565",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"green-human-resource-management-an-exploratory-study-from-moroccan-iso-14001-certified-companies",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82194",title:"CSR and Female Directors: A Review and Future Research Agenda",doi:"10.5772/intechopen.105112",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Sirimon Treepongkaruna",slug:"csr-and-female-directors-a-review-and-future-research-agenda",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},publishedBooks:{paginationCount:4,paginationItems:[{type:"book",id:"9528",title:"Current Topics and Emerging Issues in Malaria Elimination",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9528.jpg",slug:"current-topics-and-emerging-issues-in-malaria-elimination",publishedDate:"July 21st 2021",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"7f178329cc42e691efe226b32f14e2ea",volumeInSeries:8,fullTitle:"Current Topics and Emerging Issues in Malaria Elimination",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7981",title:"Overview on Echinococcosis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7981.jpg",slug:"overview-on-echinococcosis",publishedDate:"April 22nd 2020",editedByType:"Edited by",bookSignature:"Fethi Derbel and Meriem Braiki",hash:"24dee9209f3fd6b7cd28f042da0076f0",volumeInSeries:6,fullTitle:"Overview on Echinococcosis",editors:[{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",institutionString:"Clinique les Oliviers",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[{id:"14",title:"Cell and Molecular Biology",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression"},{id:"15",title:"Chemical Biology",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors"},{id:"17",title:"Metabolism",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation"},{id:"18",title:"Proteomics",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:{title:"Biochemistry",id:"11"},selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/185562",hash:"",query:{},params:{id:"185562"},fullPath:"/profiles/185562",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()