J. Eric McDuffie

J. Eric McDuffie, BSc, MBA, PhD, is the scientific director at Janssen Research and Development. He joined Janssen in 2007 and currently serves as the head of the Mechanistic and Investigative Toxicology in San Diego, California, USA. Previously, he held various positions at Pfizer, Inc. in Ann Arbor, Michigan, USA, including manager/senior scientist, Global Laboratory Core (2000–2001), and manager/principal scientist, Investigative Pathology (2001–2005). He also served as the principal scientist, Investigative Immunotoxicology at Esperion Therapeutics, a Pfizer, Inc. company, Plymouth, Michigan, USA (2006–2007). As a postdoctoral research fellow at the University of Michigan Medical School in Ann Arbor, Michigan, USA (1998–2000), he collaboratively investigated the role of pro- and anti-inflammatory cyto- and chemokines in liver, kidney, heart, and lung injury responses. He has coauthored several peer-reviewed manuscripts and book chapters and served as a coeditor for the benchmark book, Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers (2016). His plethora of research interests spans across investigative toxicologic pathology in drug development. Current investigative foci include the assessment of excitotoxicity risk using novel human iPSC-derived glutamatergic neuronal models.

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Latest work with IntechOpen by J. Eric McDuffie

Toxicologists seek to better understand the myriad of mechanisms responsible for neurotoxins. Because the incidence of neurobehavioral hazards and risks of exogenous compounds (e.g., natural toxins, synthetic molecules, and therapeutic agents) remain a subject matter of interest, predictive tools have evolved, including but not limited to novel translational in vitro models, biomarkers, newer epidemiological research tools, and well-accepted best practices for diagnosing neurotoxins in clinical practice. Taken together, the foreseen need to highlight some of the more appreciated and/or emerging tactical approaches in neurotoxicology results in a "one-stop reference" book, Neurotoxins.

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