Yusuf Tutar

Sivas Cumhuriyet University

Prof. Dr. Yusuf Tutar is the head of Basic Pharmaceutical Sciences Department and the head of Biochemistry Division at the Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey. Dr. Tutar is also an adjunct faculty at Biomedical Engineering Program at the same university. He obtained his MSc and PhD degrees at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and National Institutes of Health (NIH/NIDDK), USA. Dr. Tutar’s research is mainly focused on biochemistry, biophysics, genetics, and molecular biology with specialization in the fields of prion, drug design, cancer, protein structure-function, protein folding, microRNA, pseudogenes, molecular cancer, proteomics, genomics, and protein expression and characterization by spectroscopic and calorimetric methods.

2books edited

1chapters authored

Latest work with IntechOpen by Yusuf Tutar

Protein aggregation causes malfunction in several biochemical processes. Genetic and spontaneous formations of these transmissible spongiform encephalopathies are fatal to humans and animals. Conformational change of normal form of the protein to misfolded form causes its accumulation. The misfolded infectious protein agent forms the pathogenesis of the disease. This book presents pathology of the disease along with current knowledge of the structure-activity mechanism in the first two sections. Dyshomeostasis of metals is implicated in the pathogenesis of prions, and this influence is discussed further to understand the prion mechanism. Genetic resistance and immunobiology of the disease are elaborated in the following section. Finally, a computational study on the dynamics of the prion propagation provides a structural basis of the mechanism.

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