James Chan

Monash UniversityAustralia

Dr. James Chan’s main research interests focus on tolerance induction, autoimmune diseases, gene therapy and stem cell therapy. It is the aim of combining these areas of research that one day the fruits of this research can benefit patients at the clinic. He conducts his research using two autoimmune disease models, namely diabetes and experimental autoimmune encephalomyelitis (EAE), a model for the human disease multiple sclerosis. There are 2 main areas in his research namely 1) using gene therapy technique to genetically modify haematopoietic stem cells to induce immune tolerance for the treatment of autoimmune disease and 2) the use of stem cells from various tissues such as placental stem cells and bone marrow mesenchymal stem cells for the treatment of autoimmune diseases.

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Latest work with IntechOpen by James Chan

Autoimmune disease represents a group of more than 60 different chronic autoimmune diseases that affect approximately 6% of the population. Autoimmune diseases arise when ones immune system actively targets and destroys self tissue resulting in clinical disease with prime examples such as Lupus and Type 1 diabetes. The immune system is designed to protect us from foreign pathogens such as viruses and bacteria. However, during the process of generating immune cells for this purpose, as a negative consequence, self-reactive immune cells are also generated. This book aims to present the latest knowledge and insights regarding the different contributing factors and their interplay, discussions on several autoimmune diseases and their case studies, and therapeutic treatments, including stem cell, for autoimmune diseases.

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