Data set for training and testing.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"5387",leadTitle:null,fullTitle:"Worldwide Wound Healing - Innovation in Natural and Conventional Methods",title:"Worldwide Wound Healing",subtitle:"Innovation in Natural and Conventional Methods",reviewType:"peer-reviewed",abstract:"The book Worldwide Wound Healing - Innovation in Natural and Conventional Methods develops a set of themes on the healing and treatment of complex wounds through evidence-based practice with innovations in the use of natural and conventional methods. It is an innovative way that promotes the integration of conventional and natural perspectives in wound healing, with a unique focus on the quality of life of the patient.",isbn:"978-953-51-2806-9",printIsbn:"978-953-51-2805-2",pdfIsbn:"978-953-51-7327-4",doi:"10.5772/62668",price:119,priceEur:129,priceUsd:155,slug:"worldwide-wound-healing-innovation-in-natural-and-conventional-methods",numberOfPages:162,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"7fce44f4147d70a5f22ce850dedc729a",bookSignature:"Cesar Joao Vicente da Fonseca",publishedDate:"December 7th 2016",coverURL:"https://cdn.intechopen.com/books/images_new/5387.jpg",numberOfDownloads:14679,numberOfWosCitations:11,numberOfCrossrefCitations:8,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:18,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:37,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 12th 2015",dateEndSecondStepPublish:"December 3rd 2015",dateEndThirdStepPublish:"April 22nd 2016",dateEndFourthStepPublish:"June 6th 2016",dateEndFifthStepPublish:"July 20th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"182006",title:"Prof.",name:"César",middleName:null,surname:"Fonseca",slug:"cesar-fonseca",fullName:"César Fonseca",profilePictureURL:"https://mts.intechopen.com/storage/users/182006/images/5053_n.jpg",biography:"César João Vicente da Fonseca has received his master’s degree in Health Communication at the Universidade Aberta and PhD degree in Nursing at the University of Lisbon. He is currently a professor in the Universidade de Évora. He develops the following thematic areas: evidence-based practice; clinical decision-making; clinical guidelines; care needs assessment, control, and eradication of pain; reflection of clinical practices; organizational management of social equipment intended for older people; and health indicators of long-term care organizations. He has played roles in coordination and control team of the research and development unit of nursing schools of Lisbon, being responsible for several epidemiological research programs in the field of public health. He is responsible for international publication of several papers and the achievement of several scientific meetings in the areas described above, with international impact. He is part of the Portuguese Health Systems Observatory. Some of the papers that have been published feature great international impact factor and international relevance. There are 150 citations of the article published in international terms.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1131",title:"Global Health",slug:"global-health"}],chapters:[{id:"53204",title:"Wound Care: Traditional African Medicine Approach",doi:"10.5772/65521",slug:"wound-care-traditional-african-medicine-approach",totalDownloads:2255,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Wound care represents a major health burden in Africa. The types and causes of wounds in Africa are numerous; however, the interventions to these injuries are easily accessed in hospitals in the urban cities, while in most rural communities, the primary source of interventions is traditional medicine (TM). In recent times, there are incidences of preferences to the use of TM in the management of especially challenging wounds even when conventional interventions are available. In some African communities, there are incidences of quasi integration of conventional and traditional African medicine (TAM) in wound care. In the typical traditional African approach to wound care, diverse practices such as the use of herbal medicine, divination, and other physical interventions are common. There appears to be a favorable future for wound management using TAM with the increasing popularity due to various affirmative reasons other than poverty. The recognition, patronage, and uses of TAM for wound care as an alternative or complimentary to the conventional approach is expected to continue, hence, the need for the different regional governments in consonance with the WHO to promote the standardization, regulation, and other factors that will assure the safety and efficacy of the various practices and products of TAM.",signatures:"Philip F. Builders and Modupe I. Builders",downloadPdfUrl:"/chapter/pdf-download/53204",previewPdfUrl:"/chapter/pdf-preview/53204",authors:[{id:"182744",title:"Dr.",name:"Philip",surname:"Builders",slug:"philip-builders",fullName:"Philip Builders"},{id:"193220",title:"Dr.",name:"Modupe",surname:"Builders",slug:"modupe-builders",fullName:"Modupe Builders"}],corrections:null},{id:"53129",title:"Research in Phyto‐Constituents for Treatment of Wounds",doi:"10.5772/65485",slug:"research-in-phyto-constituents-for-treatment-of-wounds",totalDownloads:1806,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Disruption of normal architecture of skin is referred to as wound. There are different types of wounds like contusion, excision, incision, burn, diabetic, etc. The body has its own mechanism to heal wounds in three major overlapping phases, namely inflammatory, proliferative and remodelling. Any agent that promotes the healing process can be utilized as a wound healing agent. Plants have been a great source of medicines to treat wounds. Elucidation of the mechanism of wound healing helped researchers to investigate plants in detail and find out their active constituents. Various biochemical changes take place during the wound healing process, and these changes served as targets for in vitro and in vivo models. In vitro and in vivo models are extensively utilized to evaluate wound healing activity. The present chapter gives an overview of some classes of phyto‐constituents having wound healing activity.",signatures:"Chhaya H. Gadgoli",downloadPdfUrl:"/chapter/pdf-download/53129",previewPdfUrl:"/chapter/pdf-preview/53129",authors:[{id:"182683",title:"Dr.",name:"Chhaya",surname:"Gadgoli",slug:"chhaya-gadgoli",fullName:"Chhaya Gadgoli"}],corrections:null},{id:"52445",title:"In Search of Wound Healing Drugs: A Journey Through Ayurveda",doi:"10.5772/65520",slug:"in-search-of-wound-healing-drugs-a-journey-through-ayurveda",totalDownloads:1672,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Description of wound healing is a recent concern of modern surgery and medical therapeutics, but first evidences are available in ancient Indian system of medicine, namely Ayurveda in the name of Vrana (wounds) and Vranaropaka (wound healing drugs). It has been reported that in different classical Ayurvedic texts, about 164 medicinal plants, 24 metals and minerals and 18 animal products are described for their wound healing activity. The mechanism of the healing process and the selection of drugs from natural resources are very specific in Ayurveda, and some of these have been scientifically screened. Besides a single component of drug, many classical formulations either in the form of polyherbal or herbo-minerals have been cited in Ayurveda from time to time since pre-vedic era to recent modern time. Many traditional folkloric preparations of India were also later on incorporated in Ayurveda utilizing sources of some pockets of Ayurveda in different parts of the country. Chronological development of these drugs on the basis of physical, molecular and clinical parameters is elaborated vividly with some examples of experimentation like Curcuma longa, Pterocarpus santalinus, Cynodon dactylon and a composed formulation named Kshantak Malam.",signatures:"Tuhin K. Biswas, Saheli Banerjee, Nandini Poyra, Srikanta Pandit,\nUtpalendu Jana, Shrabana Chakrabarti and Tapan Seal",downloadPdfUrl:"/chapter/pdf-download/52445",previewPdfUrl:"/chapter/pdf-preview/52445",authors:[{id:"182228",title:"Dr.",name:"Tuhin Kanti",surname:"Biswas",slug:"tuhin-kanti-biswas",fullName:"Tuhin Kanti Biswas"}],corrections:null},{id:"52939",title:"Natural Compounds for Wound Healing",doi:"10.5772/65652",slug:"natural-compounds-for-wound-healing",totalDownloads:3069,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Many plants or plant-derived compounds with high levels of antioxidants and anti-inflammatory, immunomodulatory, and antimicrobial properties could be of great benefit for wound healing. Several studies have documented the use of plant extracts for the development of bioactive wound dressings. The purpose of this chapter is to give an update about the vegetal and bee products, which can be used as bioactive substances in wound dressings or in other formulations for wound healing. The adverse effects of plant and bee extracts, such as contact allergies, are also presented. In order to better exploit the huge reservoir of pharmacologically active plant-derived compounds and extracts, standardized methodology and clinical trials are necessary to give more concrete evidence supporting the use of traditional medicine in wound management.",signatures:"Mihaela Georgescu, Oana Marinas, Marcela Popa, Teodora Stan,\nVeronica Lazar, Serban Vifor Bertesteanu and Mariana Carmen\nChifiriuc",downloadPdfUrl:"/chapter/pdf-download/52939",previewPdfUrl:"/chapter/pdf-preview/52939",authors:[{id:"176120",title:"Dr.",name:"Veronica",surname:"Lazar",slug:"veronica-lazar",fullName:"Veronica Lazar"},{id:"183662",title:"Prof.",name:"Mariana Carmen",surname:"Chifiriuc",slug:"mariana-carmen-chifiriuc",fullName:"Mariana Carmen Chifiriuc"},{id:"186345",title:"BSc.",name:"Mihaela",surname:"Georgescu",slug:"mihaela-georgescu",fullName:"Mihaela Georgescu"},{id:"186346",title:"Dr.",name:"Oana",surname:"Marinas",slug:"oana-marinas",fullName:"Oana Marinas"},{id:"186347",title:"Dr.",name:"Marcela",surname:"Popa",slug:"marcela-popa",fullName:"Marcela Popa"},{id:"186348",title:"Dr.",name:"Teodora",surname:"Stan",slug:"teodora-stan",fullName:"Teodora Stan"},{id:"186349",title:"Dr.",name:"Serban Vifor",surname:"Bertesteanu",slug:"serban-vifor-bertesteanu",fullName:"Serban Vifor Bertesteanu"}],corrections:null},{id:"52856",title:"Nursing Interventions in Prevention and Healing of Leg Ulcers: Systematic Review of the Literature",doi:"10.5772/65719",slug:"nursing-interventions-in-prevention-and-healing-of-leg-ulcers-systematic-review-of-the-literature",totalDownloads:1884,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Aim: The purpose of this study was to define nursing interventions for patients with venous, arterial or mixed leg ulcers.",signatures:"César Fonseca, Manuel Lopes, Ana Ramos, Vitor Santos, Antonio\nEsquinas and Pedro Parreira",downloadPdfUrl:"/chapter/pdf-download/52856",previewPdfUrl:"/chapter/pdf-preview/52856",authors:[{id:"182006",title:"Prof.",name:"César",surname:"Fonseca",slug:"cesar-fonseca",fullName:"César Fonseca"}],corrections:null},{id:"52061",title:"Aspects Related to Venous Ulcer Healing and its Influence on Quality of Life",doi:"10.5772/64913",slug:"aspects-related-to-venous-ulcer-healing-and-its-influence-on-quality-of-life",totalDownloads:1718,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Nowadays, the varicose ulcers (VUs) are one of the most worrying leg ulcers and are an important global health problem, with high costs related to the treatment and its complications. Moreover, the quality of life (QOL) of the patient could be affected by pain, sleep disorders, functional impairment, depression, and isolation. The VU patient care is complex, and it is necessary to know the aspects that contribute to the healing process for developing effective strategies. The members of the multidisciplinary health team should identify sociodemographic, clinical, and care aspects that interfere in tissue repair and therefore impacting the QOL. Self-efficacy, adherence to treatment, and self-esteem are other important aspects also related to healing and QOL, with implications for health care and the multidisciplinary team. To sum up, the use of multidisciplinary protocols allows the systematization of care for people with VUs in order to standardize therapeutic interventions with the aim to decrease the healing process time and, as a consequence, to improve the QOL.",signatures:"Gilson V. Torres, Aline M. Pergola-Marconato, Thalyta C. Mansano-\nSchlosser, Rhayssa O. Araújo, Dalva C. Silva, Abigail Gómez-Morales,\nSandra M.S.G.S.O. Torres, Felismina R.P. Mendes and Eulália M.C.\nMaia",downloadPdfUrl:"/chapter/pdf-download/52061",previewPdfUrl:"/chapter/pdf-preview/52061",authors:[{id:"183298",title:"Dr.",name:"Gilson",surname:"Torres",slug:"gilson-torres",fullName:"Gilson Torres"},{id:"183896",title:"Dr.",name:"Thalyta Cristina",surname:"Mansano-Schlosser",slug:"thalyta-cristina-mansano-schlosser",fullName:"Thalyta Cristina Mansano-Schlosser"},{id:"183897",title:"Dr.",name:"Aline Maino",surname:"Pergola-Marconato",slug:"aline-maino-pergola-marconato",fullName:"Aline Maino Pergola-Marconato"},{id:"183898",title:"Dr.",name:"Felismina Rosa",surname:"Perreira Mendes",slug:"felismina-rosa-perreira-mendes",fullName:"Felismina Rosa Perreira Mendes"},{id:"183899",title:"Dr.",name:"Eulalia Maria",surname:"Chaves Maia",slug:"eulalia-maria-chaves-maia",fullName:"Eulalia Maria Chaves Maia"},{id:"183900",title:"MSc.",name:"Sandra Maria Da Solidade Gomes",surname:"Simões De Oliveira Torres",slug:"sandra-maria-da-solidade-gomes-simoes-de-oliveira-torres",fullName:"Sandra Maria Da Solidade Gomes Simões De Oliveira Torres"},{id:"183901",title:"MSc.",name:"Dalva Cezar",surname:"Da Silva",slug:"dalva-cezar-da-silva",fullName:"Dalva Cezar Da Silva"},{id:"183902",title:"MSc.",name:"Rhayssa",surname:"De Oliveira E Araújo",slug:"rhayssa-de-oliveira-e-araujo",fullName:"Rhayssa De Oliveira E Araújo"},{id:"183903",title:"MSc.",name:"Abigail",surname:"Gómez-Morales",slug:"abigail-gomez-morales",fullName:"Abigail Gómez-Morales"}],corrections:null},{id:"53065",title:"Placental Cells and Tissues: The Transformative Rise in Advanced Wound Care",doi:"10.5772/65321",slug:"placental-cells-and-tissues-the-transformative-rise-in-advanced-wound-care",totalDownloads:2278,totalCrossrefCites:6,totalDimensionsCites:11,hasAltmetrics:1,abstract:"The fetal environment has a remarkable capacity for facilitating and guiding tissue development. Placental tissues including the placental disc, umbilical cord, amniotic fluid and amniotic sac are highly specialized tissues responsible for transporting nutrients and coordinating developmental cues during pregnancy and fetal development. Placental tissues are nutrient-rich, structurally complex and immunologically privileged, making them promising allograft therapies for advanced wound care. Amniotic membrane allografts in particular have been shown to be effective therapies for treatment of chronic wounds, including diabetic and venous ulcers, by modulating inflammation, reducing scar tissue formation and enhancing healing. Amniotic membrane has also demonstrated the ability to promote cell proliferation, cell migration and modulate cytokine secretion by a variety of cell types involved in wound healing, including human dermal fibroblasts, microvascular endothelial cells and stem cells. In addition, amniotic membrane allografts have been shown to stimulate stem cell activity, promote angiogenesis and modulate inflammation in vitro and in vivo. Placental tissues are complex tissues composed of extracellular matrix (ECM), cells and a broad array of cytokines that may collectively enhance wound healing by modulating wound environments and stimulating endogenous cells to progress through the normal healing stages of inflammation, proliferation and remodeling.",signatures:"Jeremy J. Lim and Thomas J. Koob",downloadPdfUrl:"/chapter/pdf-download/53065",previewPdfUrl:"/chapter/pdf-preview/53065",authors:[{id:"183322",title:"Ph.D.",name:"Thomas",surname:"Koob",slug:"thomas-koob",fullName:"Thomas Koob"},{id:"194346",title:"Ph.D.",name:"Jeremy",surname:"Lim",slug:"jeremy-lim",fullName:"Jeremy Lim"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6339",title:"Towards Malaria Elimination",subtitle:"A Leap Forward",isOpenForSubmission:!1,hash:"2ab88726cd9291b2b1c29889c948c902",slug:"towards-malaria-elimination-a-leap-forward",bookSignature:"Sylvie Manguin and Vas Dev",coverURL:"https://cdn.intechopen.com/books/images_new/6339.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3432",title:"Current Topics in Public Health",subtitle:null,isOpenForSubmission:!1,hash:"bbfaa5b624db308171170cb70e9de196",slug:"current-topics-in-public-health",bookSignature:"Alfonso J. Rodriguez-Morales",coverURL:"https://cdn.intechopen.com/books/images_new/3432.jpg",editedByType:"Edited by",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1809",title:"Insight and Control of Infectious Disease in Global Scenario",subtitle:null,isOpenForSubmission:!1,hash:"3ef57f4cdbc59a806312c24bff4e3097",slug:"insight-and-control-of-infectious-disease-in-global-scenario",bookSignature:"Priti Kumar Roy",coverURL:"https://cdn.intechopen.com/books/images_new/1809.jpg",editedByType:"Edited by",editors:[{id:"95723",title:"Dr.",name:"Roy",surname:"Priti",slug:"roy-priti",fullName:"Roy Priti"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"670",title:"Addictions",subtitle:"From Pathophysiology to Treatment",isOpenForSubmission:!1,hash:"9c807a142be4c589ba8d325568a2d9ae",slug:"addictions-from-pathophysiology-to-treatment",bookSignature:"David Belin",coverURL:"https://cdn.intechopen.com/books/images_new/670.jpg",editedByType:"Edited by",editors:[{id:"97877",title:"Dr.",name:"David",surname:"Belin",slug:"david-belin",fullName:"David Belin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"762",title:"Contemporary and Innovative Practice in Palliative Care",subtitle:null,isOpenForSubmission:!1,hash:"243832000765abc39fee7009494c2ab0",slug:"contemporary-and-innovative-practice-in-palliative-care",bookSignature:"Esther Chang and Amanda Johnson",coverURL:"https://cdn.intechopen.com/books/images_new/762.jpg",editedByType:"Edited by",editors:[{id:"86476",title:"Prof.",name:"Esther",surname:"Chang",slug:"esther-chang",fullName:"Esther Chang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5171",title:"Recent Advances in Drug Addiction Research and Clinical Applications",subtitle:null,isOpenForSubmission:!1,hash:"d4d43741fe591f3102735d26db3c51a0",slug:"recent-advances-in-drug-addiction-research-and-clinical-applications",bookSignature:"William M. Meil and Christina L. Ruby",coverURL:"https://cdn.intechopen.com/books/images_new/5171.jpg",editedByType:"Edited by",editors:[{id:"87876",title:"Dr.",name:"William M.",surname:"Meil",slug:"william-m.-meil",fullName:"William M. Meil"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1886",title:"Primary Care at a Glance",subtitle:"Hot Topics and New Insights",isOpenForSubmission:!1,hash:"aa9970e335b085064f8b2b9cc44fb81d",slug:"primary-care-at-a-glance-hot-topics-and-new-insights",bookSignature:"Oreste Capelli",coverURL:"https://cdn.intechopen.com/books/images_new/1886.jpg",editedByType:"Edited by",editors:[{id:"110047",title:"Dr.",name:"Oreste",surname:"Capelli",slug:"oreste-capelli",fullName:"Oreste Capelli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5796",title:"Dengue",subtitle:"Immunopathology and Control Strategies",isOpenForSubmission:!1,hash:"ea7594d938547fcd4fe8d358527695b0",slug:"dengue-immunopathology-and-control-strategies",bookSignature:"Márcia Aparecida Sperança",coverURL:"https://cdn.intechopen.com/books/images_new/5796.jpg",editedByType:"Edited by",editors:[{id:"176579",title:"Ph.D.",name:"Márcia Aparecida",surname:"Sperança",slug:"marcia-aparecida-speranca",fullName:"Márcia Aparecida Sperança"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7222",title:"Current Topics in Tropical Emerging Diseases and Travel Medicine",subtitle:null,isOpenForSubmission:!1,hash:"35b395a032b539cba98549da7d337bd1",slug:"current-topics-in-tropical-emerging-diseases-and-travel-medicine",bookSignature:"Alfonso J. Rodriguez-Morales",coverURL:"https://cdn.intechopen.com/books/images_new/7222.jpg",editedByType:"Edited by",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,isOpenForSubmission:!1,hash:"61c627da05b2ace83056d11357bdf361",slug:"current-topics-in-neglected-tropical-diseases",bookSignature:"Alfonso J. Rodriguez-Morales",coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",editedByType:"Edited by",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"81454",slug:"corrigendum-to-production-of-sustainable-concrete-by-using-challenging-environmentally-friendly-mate",title:"Corrigendum to: Production of Sustainable Concrete by Using Challenging Environmentally Friendly Materials Instead of Cement",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/81454.pdf\r\n",downloadPdfUrl:"/chapter/pdf-download/81454",previewPdfUrl:"/chapter/pdf-preview/81454",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/81454",risUrl:"/chapter/ris/81454",chapter:{id:"77888",slug:"production-of-sustainable-concrete-by-using-challenging-environmentally-friendly-materials-instead-o",signatures:"Abebe Demissew Gashahun",dateSubmitted:"April 13th 2021",dateReviewed:"July 5th 2021",datePrePublished:"September 23rd 2021",datePublished:"May 4th 2022",book:{id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,fullTitle:"Sustainability of Concrete With Synthetic and Recycled Aggregates",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",publishedDate:"May 4th 2022",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"347459",title:"Mr.",name:"Abebe",middleName:"Demissew",surname:"Demissew Gashahun",fullName:"Abebe Demissew Gashahun",slug:"abebe-demissew-gashahun",email:"abebe_demissew@dmu.edu.et",position:null,institution:{name:"Debre Markos University",institutionURL:null,country:{name:"Ethiopia"}}}]}},chapter:{id:"77888",slug:"production-of-sustainable-concrete-by-using-challenging-environmentally-friendly-materials-instead-o",signatures:"Abebe Demissew Gashahun",dateSubmitted:"April 13th 2021",dateReviewed:"July 5th 2021",datePrePublished:"September 23rd 2021",datePublished:"May 4th 2022",book:{id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,fullTitle:"Sustainability of Concrete With Synthetic and Recycled Aggregates",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",publishedDate:"May 4th 2022",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"347459",title:"Mr.",name:"Abebe",middleName:"Demissew",surname:"Demissew Gashahun",fullName:"Abebe Demissew Gashahun",slug:"abebe-demissew-gashahun",email:"abebe_demissew@dmu.edu.et",position:null,institution:{name:"Debre Markos University",institutionURL:null,country:{name:"Ethiopia"}}}]},book:{id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,fullTitle:"Sustainability of Concrete With Synthetic and Recycled Aggregates",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",publishedDate:"May 4th 2022",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"12088",leadTitle:null,title:"Ataxia",subtitle:null,reviewType:"peer-reviewed",abstract:"This book will be a self-contained collection of scholarly papers targeting an audience of practicing researchers, academics, PhD students and other scientists. The contents of the book will be written by multiple authors and edited by experts in the field.",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"fb35aa995feab6834b56ef9828065b3e",bookSignature:"",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12088.jpg",keywords:null,numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 2nd 2022",dateEndSecondStepPublish:"March 23rd 2022",dateEndThirdStepPublish:"May 22nd 2022",dateEndFourthStepPublish:"August 10th 2022",dateEndFifthStepPublish:"October 9th 2022",remainingDaysToSecondStep:"2 months",secondStepPassed:!0,currentStepOfPublishingProcess:1,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:null},relatedBooks:[{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. Mauricio Barría",coverURL:"https://cdn.intechopen.com/books/images_new/6550.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. Mauricio Barría"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9500",title:"Recent Advances in Bone Tumours and Osteoarthritis",subtitle:null,isOpenForSubmission:!1,hash:"ea4ec0d6ee01b88e264178886e3210ed",slug:"recent-advances-in-bone-tumours-and-osteoarthritis",bookSignature:"Hiran Amarasekera",coverURL:"https://cdn.intechopen.com/books/images_new/9500.jpg",editedByType:"Edited by",editors:[{id:"67634",title:"Dr.",name:"Hiran",surname:"Amarasekera",slug:"hiran-amarasekera",fullName:"Hiran Amarasekera"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"33",title:"Legged Robotic Systems",doi:"10.5772/4669",slug:"legged_robotic_systems",body:null,keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/33.pdf",chapterXML:null,downloadPdfUrl:"/chapter/pdf-download/33",previewPdfUrl:"/chapter/pdf-preview/33",totalDownloads:7009,totalViews:188,totalCrossrefCites:40,totalDimensionsCites:59,totalAltmetricsMentions:0,impactScore:22,impactScorePercentile:99,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:null,dateReviewed:null,datePrePublished:null,datePublished:"July 1st 2005",dateFinished:null,readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/33",risUrl:"/chapter/ris/33",book:{id:"5787",slug:"cutting_edge_robotics"},signatures:"Giuseppe Carbone and Marco Ceccarelli",authors:null,sections:null,chapterReferences:null,footnotes:null,contributors:null,corrections:null},book:{id:"5787",type:"book",title:"Cutting Edge Robotics",subtitle:null,fullTitle:"Cutting Edge Robotics",slug:"cutting_edge_robotics",publishedDate:"July 1st 2005",bookSignature:"Vedran Kordic, Aleksandar Lazinica and Munir Merdan",coverURL:"https://cdn.intechopen.com/books/images_new/5787.jpg",licenceType:"CC BY-NC-SA 3.0",editedByType:"Edited by",isbn:null,printIsbn:"3-86611-038-3",pdfIsbn:"978-953-51-5800-4",reviewType:"peer-reviewed",numberOfWosCitations:125,isAvailableForWebshopOrdering:!0,editors:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica"},coeditorTwo:{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan"},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1293"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"1",type:"chapter",title:"Dynamic Modelling and Adaptive Traction Control for Mobile Robots",slug:"dynamic_modelling_and_adaptive_traction_control_for_mobile_robots",totalDownloads:4926,totalCrossrefCites:0,signatures:"Abdulgani Albagul, Wahyudi Martono and Riza Muhida",reviewType:"peer-reviewed",authors:[null]},{id:"2",type:"chapter",title:"Rapid Prototyping for Robotics",slug:"rapid_prototyping_for_robotics",totalDownloads:7895,totalCrossrefCites:8,signatures:"Imme Ebert-Uphoff, Clement M. Gosselin, David W. Rosen and Thierry Laliberte",reviewType:"peer-reviewed",authors:[null]},{id:"3",type:"chapter",title:"The Role of 3D Simulation in the Advanced Robotic Design, Test and Control",slug:"the_role_of_3d_simulation_in_the_advanced_robotic_design__test_and_control",totalDownloads:5041,totalCrossrefCites:2,signatures:"Laszlo Vajta and Tamas Juhasz",reviewType:"peer-reviewed",authors:[null]},{id:"4",type:"chapter",title:"Mechatronics Design of a Mecanum Wheeled Mobile Robot",slug:"mechatronics_design_of_a_mecanum_wheeled_mobile_robot",totalDownloads:6964,totalCrossrefCites:5,signatures:"Peter Xu",reviewType:"peer-reviewed",authors:[null]},{id:"5",type:"chapter",title:"Tracking Skin-Colored Objects in Real-Time",slug:"tracking_skin-colored_objects_in_real-time",totalDownloads:3950,totalCrossrefCites:0,signatures:"Antonis A. Argyros and Manolis I.A. Lourakis",reviewType:"peer-reviewed",authors:[null]},{id:"6",type:"chapter",title:"Feature Extraction and Grouping for Robot Vision Tasks",slug:"feature_extraction_and_grouping_for_robot_vision_tasks",totalDownloads:2901,totalCrossrefCites:0,signatures:"Miguel Cazorla and Francisco Escolano",reviewType:"peer-reviewed",authors:[null]},{id:"7",type:"chapter",title:"Comparison of Demosaicking Methods for Color Information Extraction",slug:"comparison_of_demosaicking_methods_for_color_information_extraction",totalDownloads:4504,totalCrossrefCites:0,signatures:"Flore Faille",reviewType:"peer-reviewed",authors:[null]},{id:"8",type:"chapter",title:"Robot Motion Trajectory-Measurement with Linear Inertial Sensors",slug:"robot_motion_trajectory-measurement_with_linear_inertial_sensors",totalDownloads:7596,totalCrossrefCites:1,signatures:"Bernard Favre Bulle",reviewType:"peer-reviewed",authors:[null]},{id:"9",type:"chapter",title:"Supervisory Controller for Task Assignment and Resource Dispatching in Mobile Wireless Sensor Networks",slug:"supervisory_controller_for_task_assignment_and_resource_dispatching_in_mobile_wireless_sensor_networ",totalDownloads:2571,totalCrossrefCites:2,signatures:"Vincenzo Giordano, Frank Lewis, Prasanna Ballal and Biagio Turchiano",reviewType:"peer-reviewed",authors:[null]},{id:"10",type:"chapter",title:"Design of a Generic, Vectorised, Machine-Vision library",slug:"design_of_a_generic__vectorised__machine-vision_library",totalDownloads:3552,totalCrossrefCites:0,signatures:"Bing-Chang Lai and Phillip John McKerrow",reviewType:"peer-reviewed",authors:[null]},{id:"11",type:"chapter",title:"An Active Stereo Vision-Based Learning Approach for Robotic Tracking, Fixating and Grasping Control",slug:"an_active_stereo_vision-based_learning_approach_for_robotic_tracking__fixating_and_grasping_control",totalDownloads:2751,totalCrossrefCites:1,signatures:"Nan-Feng Xiao and Saeid Nahavandi",reviewType:"peer-reviewed",authors:[null]},{id:"12",type:"chapter",title:"Managing Limited Sensing Resources for Mobile Robots Obstacle Avoidance",slug:"managing_limited_sensing_resources_for_mobile_robots_obstacle_avoidance",totalDownloads:3315,totalCrossrefCites:0,signatures:"Juan Carlos Alvarez, Rafael C. Gonzalez, Diego Alvarez and Antonio M. Lopez",reviewType:"peer-reviewed",authors:[null]},{id:"13",type:"chapter",title:"Behaviour Based Mobile Robot Navigation with Dynamic Weighted Voting Technique",slug:"behaviour_based_mobile_robot_navigation_with_dynamic_weighted_voting_technique",totalDownloads:3882,totalCrossrefCites:0,signatures:"Shamsudin H.M. Amin, Rosbi Mamat and Tan Chee Kwong",reviewType:"peer-reviewed",authors:[null]},{id:"14",type:"chapter",title:"Stochastic State Estimation for Simultaneous Localization and Map Building in Mobile Robotics",slug:"stochastic_state_estimation_for_simultaneous_localization_and_map_building_in_mobile_robotics",totalDownloads:3174,totalCrossrefCites:1,signatures:"Juan Andrade Cetto, Teresa A. Vidal Calleja and Alberto Sanfeliu",reviewType:"peer-reviewed",authors:[null]},{id:"15",type:"chapter",title:"Neural Networks in Mobile Robot Motion",slug:"neural-network-in-mobile-robot-motion",totalDownloads:3032,totalCrossrefCites:11,signatures:"Danica Janglova",reviewType:"peer-reviewed",authors:[null]},{id:"16",type:"chapter",title:"Generating Timed Trajectories for Autonomous Robotic Platforms: A Non-Linear Dynamical Systems Approach",slug:"generating_timed_trajectories_for_autonomous_robotic_platforms__a_non-linear_dynamical_systems_appro",totalDownloads:2857,totalCrossrefCites:0,signatures:"Cristina Manuela Peixoto dos Santos",reviewType:"peer-reviewed",authors:[null]},{id:"17",type:"chapter",title:"Coevolution Based Adaptive Monte Carlo Localization",slug:"coevolution_based_adaptive_monte_carlo_localization",totalDownloads:2400,totalCrossrefCites:0,signatures:"Luo Ronghua, Hong Bingrong and Li Maohai",reviewType:"peer-reviewed",authors:[null]},{id:"18",type:"chapter",title:"Autonomous Navigation of Unmanned Vehicles: A Fuzzy Logic Perspective",slug:"autonomous_navigation_of_unmanned_vehicles__a_fuzzy_logic_perspective",totalDownloads:6318,totalCrossrefCites:0,signatures:"Nikos C. Tsourveloudis, Lefteris Doitsidis and Kimon P. Valavanis",reviewType:"peer-reviewed",authors:[null]},{id:"19",type:"chapter",title:"Integrating Behaviors for Mobile Robots: an Ethological Approach",slug:"integrating_behaviors_for_mobile_robots__an_ethological_approach",totalDownloads:3148,totalCrossrefCites:0,signatures:"Jose Maria Canas Plaza and Vicente Matellan Olivera",reviewType:"peer-reviewed",authors:[null]},{id:"20",type:"chapter",title:"Stabilization of Fuzzy Takagi - Sugeno Descriptor Models; Application to a Double Inverted Pendulum",slug:"stabilization_of_fuzzy_takagi_-_sugeno_descriptor_models__application_to_a_double_inverted_pendulum",totalDownloads:4043,totalCrossrefCites:0,signatures:"Thierry Marie Guerra, Sebastien Delprat and Salim Labiod",reviewType:"peer-reviewed",authors:[null]},{id:"21",type:"chapter",title:"Adaptive Control of Nonlinear Dynamics Systems Based on RBF Network",slug:"adaptive_control_of_nonlinear_dynamics_systems_based_on_rbf_network",totalDownloads:3381,totalCrossrefCites:0,signatures:"Ho Dac Loc, Nguyen Thi Phuong Ha and Luong Van Lang",reviewType:"peer-reviewed",authors:[null]},{id:"22",type:"chapter",title:"Multi-Layered Learning System for Real Robot Behavior Acquisition",slug:"multi-layered_learning_system_for_real_robot_behavior_acquisition",totalDownloads:2635,totalCrossrefCites:1,signatures:"Yasutake Takahashi and Minoru Asada",reviewType:"peer-reviewed",authors:[null]},{id:"23",type:"chapter",title:"The Design of a Pair of Identical Mobile Robots to Investigate Cooperative Behaviours",slug:"the_design_of_a_pair_of_identical_mobile_robots_to_investigate_co_-_operative_behaviours",totalDownloads:4281,totalCrossrefCites:1,signatures:"Dale Carnegie, Andrew Payne and Praneel Chand",reviewType:"peer-reviewed",authors:[null]},{id:"24",type:"chapter",title:"Cooperative Hunting by Multiple Mobile Robots Based on Local Interaction",slug:"cooperative_hunting_by_multiple_mobile_robots_based_on_local_interaction",totalDownloads:2741,totalCrossrefCites:1,signatures:"Zhi-Qiang Cao, Min Tan, Saeid Nahavandi and Nong Gu",reviewType:"peer-reviewed",authors:[null]},{id:"25",type:"chapter",title:"Market-Driven Multi-Agent Collaboration in Robot Soccer Domain",slug:"market-driven_multi-agent_collaboration_in_robot_soccer_domain",totalDownloads:3310,totalCrossrefCites:9,signatures:"Hatice Kose, Kemal Kaplan, Cetin Mericli, Utku Tatlidede and Levent Akin",reviewType:"peer-reviewed",authors:[null]},{id:"26",type:"chapter",title:"The SocRob Project: Soccer Robots or Society of Robots",slug:"the_socrob_project__soccer_robots_or_society_of_robots",totalDownloads:3192,totalCrossrefCites:0,signatures:"Pedro U. Lima and Luis M. M. Custodio",reviewType:"peer-reviewed",authors:[null]},{id:"27",type:"chapter",title:"RoboCup is a Stage which Impulse the Research of Basic Technology in Robot",slug:"robocup_is_a_stage_which_impulse_the_research_of_basic_technology_in_robot",totalDownloads:3178,totalCrossrefCites:1,signatures:"Cheng Xian-yi and Xia De-shen",reviewType:"peer-reviewed",authors:[null]},{id:"28",type:"chapter",title:"A Multi-Robot System Architecture for Trajectory Control of Groups of People",slug:"a_multi-robot_system_architecture_for_trajectory_control_of_groups_of_people",totalDownloads:2762,totalCrossrefCites:0,signatures:"Edgar A. Martinez-Garcia, Akihisa Ohya and Shinichi Yuta",reviewType:"peer-reviewed",authors:[null]},{id:"29",type:"chapter",title:"Sharing and Trading in a Human-Robot System",slug:"sharing_and_trading_in_a_human-robot_system",totalDownloads:2999,totalCrossrefCites:0,signatures:"Kai Wei Ong, Gerald Seet and Siang Kok Sim",reviewType:"peer-reviewed",authors:[null]},{id:"30",type:"chapter",title:"A Robotic System for Volcano Exploration",slug:"a_robotic_system_for_volcano_exploration",totalDownloads:5777,totalCrossrefCites:10,signatures:"Daniele Caltabiano and Giovanni Muscato",reviewType:"peer-reviewed",authors:[null]},{id:"31",type:"chapter",title:"A Simulator for Helping in Design of a New Active Catheter Dedicated to Coloscopy",slug:"a_simulator_for_helping_in_design_of_a_new_active_catheter_dedicated_to_coloscopy",totalDownloads:2486,totalCrossrefCites:0,signatures:"Georges Dumont and Christofer Kuehl",reviewType:"peer-reviewed",authors:[null]},{id:"32",type:"chapter",title:"Development of a Range of Robot and Automation Prototypes for Service Applications",slug:"development_of_a_range_of_robot_and_automation_prototypes_for_service_applications",totalDownloads:4603,totalCrossrefCites:0,signatures:"Bing Lam Luk, Alexandar Djordjevic, Shiu Kit Tso and King Pui Liu",reviewType:"peer-reviewed",authors:[null]},{id:"33",type:"chapter",title:"Legged Robotic Systems",slug:"legged_robotic_systems",totalDownloads:7009,totalCrossrefCites:40,signatures:"Giuseppe Carbone and Marco Ceccarelli",reviewType:"peer-reviewed",authors:[null]},{id:"34",type:"chapter",title:"Humanoid Robot Motion in Unstructured Environment - Generation of Various Gait Patterns from a Single Nominal",slug:"humanoid_robot_motion_in_unstructured_environment_-_generation_of_various_gait_patterns_from_a_singl",totalDownloads:2822,totalCrossrefCites:2,signatures:"Miomir Vukobratovic, Dejan Andric and Branislav Borovac",reviewType:"peer-reviewed",authors:[null]},{id:"35",type:"chapter",title:"Trajectory Planning of a Constrained Flexible Manipulator",slug:"trajectory_planning_of_a_constrained_flexible_manipulator",totalDownloads:2893,totalCrossrefCites:1,signatures:"Atef A. Ata and Habib Johar",reviewType:"peer-reviewed",authors:[null]},{id:"36",type:"chapter",title:"Position / Force Hybrid Control of a Manipulator with a Flexible Tool Using Visual and Force Information",slug:"position___force_hybrid_control_of_a_manipulator_with_a_flexible_tool_using_visual_and_force_informa",totalDownloads:3683,totalCrossrefCites:1,signatures:"Jian Huang, Isao Todo and Tetsuro Yabuta",reviewType:"peer-reviewed",authors:[null]},{id:"37",type:"chapter",title:"A Novel Parallel Engraving Machine Based on 6-PUS Mechanism and Related Technologies",slug:"a_novel_parallel_engraving_machine_based_on_6-pus_mechanism_and_related_technologies",totalDownloads:2762,totalCrossrefCites:0,signatures:"Kong Ling-fu and Zhang Shi-hui",reviewType:"peer-reviewed",authors:[null]},{id:"38",type:"chapter",title:"Pose Estimating the Human Arm Using Kinematics and the Sequential Monte Carlo Framework",slug:"pose_estimating_the_human_arm_using_kinematics_and_the_sequential_monte_carlo_framework",totalDownloads:3094,totalCrossrefCites:1,signatures:"Thomas Moeslund",reviewType:"peer-reviewed",authors:[null]},{id:"39",type:"chapter",title:"Cartesian Impedance Control of Flexible Joint Robots: A Decoupling Approach",slug:"cartesian_impedance_control_of_flexible_joint_robots__a_decoupling_approach",totalDownloads:4516,totalCrossrefCites:2,signatures:"Christian Ott, Alin Albu Schaffer, Andreas Kugi and Gerd Hirzinger",reviewType:"peer-reviewed",authors:[null]},{id:"40",type:"chapter",title:"Collision-Free Path Planning in Robot Cells Using Virtual 3D Collision Sensors",slug:"collision-free_path_planning_in_robot_cells_using_virtual_3d_collision_sensors",totalDownloads:3306,totalCrossrefCites:2,signatures:"Tomislav Reichenbach and Zdenko Kovacic",reviewType:"peer-reviewed",authors:[null]},{id:"41",type:"chapter",title:"Exploring Open-Ended Design Space of Mechatronic Systems",slug:"exploring_open-ended_design_space_of_mechatronic_systems",totalDownloads:3229,totalCrossrefCites:0,signatures:"Zhun Fan, Jiachuan Wang and Erik Goodman",reviewType:"peer-reviewed",authors:[null]},{id:"42",type:"chapter",title:"Online Identification for the Automated Threaded Fastening Using GUI Format",slug:"online_identification_for_the_automated_threaded_fastening_using_gui_format",totalDownloads:3269,totalCrossrefCites:0,signatures:"Nicola Ivan Giannoccaro and Mongkorn Klingajay",reviewType:"peer-reviewed",authors:[null]},{id:"43",type:"chapter",title:"Multilevel Intelligent Control of Mechatronical Technological Systems",slug:"multilevel_intelligent_control_of_mechatronical_technological_systems",totalDownloads:2636,totalCrossrefCites:0,signatures:"Tugengold Andrei Kirillovich, Ryzhkin Anatoliy Andreevich, Lukianov Evjeny Anatolievich and Wojciechowicz Boleslav",reviewType:"peer-reviewed",authors:[null]},{id:"44",type:"chapter",title:"A Robot System for High Quality Belt Grinding and Polishing Processes",slug:"a_robot_system_for_high_quality_belt_grinding_and_polishing_processes",totalDownloads:5256,totalCrossrefCites:3,signatures:"Bernd Kuhlenkoetter and Xiang Zhang",reviewType:"peer-reviewed",authors:[null]},{id:"45",type:"chapter",title:"Reconfigurable Mechatronic Robotic Plug-and-Play Controller",slug:"reconfigurable_mechatronic_robotic_plug-and-play_controller",totalDownloads:4231,totalCrossrefCites:1,signatures:"Johan Potgieter, Jonathan Zyzalo and Olaf Diegel",reviewType:"peer-reviewed",authors:[null]}]},relatedBooks:[{type:"book",id:"5330",title:"Petri Net",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:"4ebb7d10fa68cbcab11de39a524f2581",slug:"petri_net_theory_and_applications",bookSignature:"Vedran Kordic",coverURL:"https://cdn.intechopen.com/books/images_new/5330.jpg",editedByType:"Edited by",editors:[{id:"396",title:"Dr.",name:"Vedran",surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"708",title:"Petri Net Transformations",slug:"petri_net_transformations",signatures:"Hartmut Ehrig, Kathrin Hoffmann, Julia Padberg, Claudia Ermel, Ulrike Prange, Enrico Biermann and Tony Modica",authors:[null]},{id:"709",title:"Modelling and Analysis of Real-Time Systems with RTCP-Nets",slug:"modelling_and_analysis_of_real-time_systems_with_rtcp-nets",signatures:"Marcin Szpyrka",authors:[null]},{id:"710",title:"Petri Net Based Modelling of Communication in Systems on Chip",slug:"petri_net_based_modelling_of_communication_in_systems_on_chip",signatures:"Holger Blume, Thorsten von Sydow, Jochen Schleifer and Tobias G. Noll",authors:[null]},{id:"711",title:"An Inter-Working Petri Net Model between SIMPLE and IMPS for XDM Service",slug:"an_inter-working_petri_net_model_between_simple_and_imps_for_xdm_service",signatures:"Jianxin Liao, Yuting Zhang and Xiaomin Zhu",authors:[null]},{id:"712",title:"Modelling Systems by Hybrid Petri Nets: an Application to Supply Chains",slug:"modelling_systems_by_hybrid_petri_nets__an_application_to_supply_chains",signatures:"Mariagrazia Dotoli, Maria Pia Fanti, Alessandro Giua and Carla Seatzu",authors:[null]},{id:"713",title:"Modeling and Analysis of Hybrid Dynamic Systems Using Hybrid Petri Nets",slug:"modeling_and_analysis_of_hybrid_dynamic_systems_using_hybrid_petri_nets",signatures:"Latefa Ghomri and Hassane Alla",authors:[null]},{id:"714",title:"Use of Petri Nets for Modeling an Agent-Based Interactive System: Basic Principles and Case Study",slug:"use_of_petri_nets_for_modeling_an_agent-based_interactive_system__basic_principles_and_case_study",signatures:"Houcine Ezzedine and Christophe Kolski",authors:[null]},{id:"715",title:"On the Use of Queueing Petri Nets for Modeling and Performance Analysis of Distributed Systems",slug:"on_the_use_of_queueing_petri_nets_for_modeling_and_performance_analysis_of_distributed_systems",signatures:"Samuel Kounev and Alejandro Buchmann",authors:[null]},{id:"716",title:"Model Checking of Time Petri Nets",slug:"model_checking_of_time_petri_nets",signatures:"Hanifa Boucheneb and Rachid Hadjidj",authors:[null]},{id:"717",title:"A Linear Logic Based Approach to Timed Petri Nets",slug:"a_linear_logic_based_approach_to_timed_petri_nets",signatures:"Norihiro Kamide",authors:[null]},{id:"718",title:"From Time Petri Nets to Timed Automata",slug:"from_time_petri_nets_to_timed_automata",signatures:"Franck Cassez and Olivier H. Roux",authors:[null]},{id:"719",title:"Timed Hierarchical Object-Oriented Petri Net",slug:"timed_hierarchical_object-oriented_petri_net",signatures:"Hua Xu",authors:[null]},{id:"720",title:"Scheduling Analysis of FMS Using the Unfolding Time Petri Nets",slug:"scheduling_analysis_of_fms_using_the_unfolding_time_petri_nets",signatures:"Jong kun Lee and Ouajdi Korbaa",authors:[null]},{id:"721",title:"Error Recovery in Production Systems: A Petri Net Based Intelligent System Approach",slug:"error_recovery_in_production_systems__a_petri_net_based_intelligent_system_approach",signatures:"Nicholas G. Odrey",authors:[null]},{id:"722",title:"Estimation of Mean Response Time of MultiAgent Systems Using Petri Nets",slug:"estimation_of_mean_response_time_of_multi-agent_systems_using_petri_nets",signatures:"Tomasz Babczyński and Jan Magott",authors:[null]},{id:"723",title:"Diagnosis of Discrete Event Systems with Petri Nets",slug:"diagnosis_of_discrete_event_systems_with_petri_nets",signatures:"Dimitri Lefebvre",authors:[null]},{id:"724",title:"Augmented Marked Graphs and the Analysis of Shared Resource Systems",slug:"augmented_marked_graphs_and_the_analysis_of_shared_resource_systems",signatures:"King Sing Cheung",authors:[null]},{id:"725",title:"Incremental Integer Linear Programming Models for Petri Nets Reachability Problems",slug:"incremental_integer_linear_programming_models_for_petri_nets_reachability_problems",signatures:"Thomas Bourdeaud'huy, Said Hanafi and Pascal Yim",authors:[null]},{id:"726",title:"Using Transition Invariants for Reachability Analysis of Petri Nets",slug:"using_transition_invariants_for_reachability_analysis_of_petri_nets",signatures:"Alexander Kostin",authors:[null]},{id:"727",title:"Reliability Prediction and Sensitivity Analysis of Web Services Composition",slug:"reliability_prediction_and_sensitivity_analysis_of_web_services_composition",signatures:"Duhang Zhong, Zhichang Qi and Xishan Xu",authors:[null]},{id:"728",title:"Petri Nets for Component-Based Software Systems Development",slug:"petri_nets_for_component-based_software_systems_development",signatures:"Leandro Dias da Silva, Kyller Gorgonio, and Angelo Perkusich",authors:[null]},{id:"729",title:"Formalizing and Validating UML Architecture Description of Service-Oriented Applications",slug:"formalizing_and_validating_uml_architecture_description_of_service-oriented_applications",signatures:"Zhijiang Dong, Yujian Fu, Xudong He and Yue Fu",authors:[null]},{id:"730",title:"Music Description and Processing: An Approach Based on Petri Nets and XML",slug:"music_description_and_processing__an_approach_based_on_petri_nets_and_xml",signatures:"Adriano Barate",authors:[null]}]}],publishedBooks:[{type:"book",id:"5787",title:"Cutting Edge Robotics",subtitle:null,isOpenForSubmission:!1,hash:"f5caeb19605b2ebe7260f03131c26a24",slug:"cutting_edge_robotics",bookSignature:"Vedran Kordic, Aleksandar Lazinica and Munir Merdan",coverURL:"https://cdn.intechopen.com/books/images_new/5787.jpg",editedByType:"Edited by",editors:[{id:"396",title:"Dr.",name:"Vedran",surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[]},onlineFirst:{chapter:{type:"chapter",id:"62974",title:"Machine Learning Methods for Breast Cancer Diagnostic",doi:"10.5772/intechopen.79446",slug:"machine-learning-methods-for-breast-cancer-diagnostic",body:'Breast cancer is one of the most dangerous and common reproductive cancers that affect mostly women. The oldest documented cases of breast cancer were in Egypt in 3000 BC [1]. Breast tumor is an abnormal growth of tissues in the breast, and it may be felt as a lump or nipple discharge or change of skin texture around the nipple region. Cancers are abnormal cells that divide uncontrollably and are able to invade other tissues. Cancer cells have the ability to spread to other parts of the body through the blood and lymphatic systems [1]. It is the leading cause of death among middle aged and older women [1]. According to cancer statistics, breast cancer is the second most common and the leading cause of cancer deaths among women, second only to lung cancer [1]. Around 1 in 36 (3%) women dies due to breast cancer [2]. It has become a major health issue in the past 50 years, and its incidence has increased in recent years [1]; in Malaysia, breast cancer is the most frequent type of cancer among women. It has an incidence rate of about 26% (more than 4400 women) among cancer affecting women. Around 40% of the women who suffered from breast cancer in Malaysia have died (IARC). Hence, determining the right decision from a right diagnosis is crucial.
In today’s world with the advent of personalized medicine, it increases the workload and complexity of the doctors in cancer diagnosis. Radiologic and pathology are the key players in making decision for cancer diagnosis. Based on the radiology diagnosis, the results will be submitted to pathology for further diagnosis. Pathology and radiology form the core of cancer diagnosis, yet based on our observation at our studied hospital and under current process of diagnostic medicine, the communication among them remained on papers. That paper contains their respective report of the case on the same patient. This scenario is in parallel with what James et al. [3] had highlighted in their paper. The working flows of both specialties remain ad hoc and occur in separate “silos,” with no direct linkage between their case accessioning and/or reporting systems, even when both departments belong to the same host institution. Since both radiologists’ and pathologists’ data are essential to make correct diagnoses and appropriate patient management and treatment decisions, the isolation of radiology and pathology work flows can be detrimental to the quality and outcomes of patient care. These detrimental effects underscore the need for pathology and radiology work flow integration and for systems that facilitate the synthesis of all data produced by both specialties. With the enormous technological advances currently occurring in both fields, the opportunity has emerged to develop an integrated diagnostic reporting system that supports both specialties and, therefore, improves the overall quality of patient care. In this chapter, we are focusing on breast cancer diagnostic for data collected from UKMMC. Hence, breast radio-pathological correlation is essential. The covered topics would include radio-pathological correlation with recent imaging advances such as machine learning with use of technical methods such as mammography and histopathology.
As a standard, the current diagnostic screening consists of a mammography to identify suspicious regions of the breast, followed by a biopsy of potentially cancerous areas. A breast biopsy is a diagnostic procedure that can determine if the suspicious area is malignant or benign [4, 5, 6]. Although criteria for diagnostic categories of radiologic and pathology are well established, manually detection and grading respectively is a tedious and subjective process and thus suffers from inter-observer and intra-observer variations. Early detection via mammography increases breast cancer treatment options and the survival rate. However, mammography is not perfect. Detection of suspicious abnormalities is a repetitive and fatiguing task. For every thousand cases analyzed by a radiologist, only three to four are cancerous, and thus an abnormality may be overlooked. As a result, radiologists fail to detect 10–30% of cancers. Approximately two thirds of these false-negative results are due to missed lesions that are evident retrospectively. Due to the considerable amount of overlap in the appearance of malignant and benign abnormalities, mammography has a positive predictive value (PPV) of less than 35%, where the PPV is defined as the percentage of lesions subjected to biopsy that were found to be cancer. Thus, a high proportion of biopsies are performed on benign lesions. Avoiding benign biopsies would spare women anxiety, discomfort, and expense [7]. As mentioned earlier, with the advent of personalized medicine, the process becomes more complex. Not only that, the emerging of 4th Industrial Revolution (4IR) technology allowed huge amount of data to be captured, and this contributes to the complexity of the radiology and pathology workload. To address these challenges, many researchers are leveraging artificial intelligence to improve medical diagnostics. Machine learning is a sub discipline in the field of artificial intelligence (AI) that explores the study and design of algorithms that can learn from data [8].
ML comprises a broad class of statistical analysis algorithms that iteratively improve in response to training data to build models for autonomous predictions. In other words, computer program performance improves automatically with experience [9]. ML algorithm’s aim is to develop a mathematical model that fits the data. It comprises of two types of learning which are supervised and unsupervised. Supervised learning algorithm required the data to be labeled for training purposes. For example, in training a set of medical images to identify a specific breast tumor type, the label would be tumor pathologic results or genomic information. These labels, also known as ground truth, can be as specific or general as needed to answer the question. The ML algorithm is exposed to enough of these labeled data to allow them to move into a model designed to answer the question of interest. Because of the large number of well-labeled images required to train models, curating these data sets is often laborious and expensive [10]. Unsupervised ML clusters the data that have similar characteristics, and the unlabeled data are exposed to the algorithm with the goal of generating labels that will meaningfully organize the data. This is typically done by identifying useful clusters of data based on one or more dimensions. Compared with supervised techniques, unsupervised learning sometimes requires much larger training data sets. Unsupervised learning is useful in identifying meaningful clustering labels that can then be used in supervised training to develop a useful ML algorithm. This blend of supervised and unsupervised learning is known as semi-supervised.
ML algorithms are to analyze any data set to extract data-driven model, prediction rule, or decision rule from the data set. Generally, in order to ensure the ML behave intelligently without human intervention, the system learns or extracts knowledge such as rules or patterns from a collection of input data or past experience. So the steps involved can be described as firstly, the system must acquire features from data. Elaboration of features is well explained in our previous work [11, 12]. Feature selection is very important as it contains information that can be used to train the system to identify specific patterns. The pixels are rich with qualitative abstractions or values of the input. Second step is analyzing all these features for detecting and classifying possible pattern or abnormality. Finally, the step is involving a ML algorithm to determine a best suitable model to represent the behavior or the pattern of the data [13].
Various machine learning algorithms are now used to develop high-performance medical image processing systems such as computer-aided detection (CADe) system that detects clinically significant objects from medical images and computer-aided diagnosis (CADx) system that quantifies malignancy of manually or automatically detected clinical objects [14]. Therefore, CADe for mass in mammogram detects the suspicious region in the mammogram then tries to reduce the false positive and finally classifies this region to a mass or nonmass. In CADx for mass in a mammogram, most researchers use a Region of Interest (ROI) that contains the mass as an input to the CADx. Then, CADx tries to classify it into benign or malignant and gives the appropriate recommendation to do biopsy or follow-up screening [15]. Recent studies have shown that CAD systems, when used as an aid, have improved radiologists’ accuracy of detection of breast cancer and also pathology decision [1, 7, 16]. It is worthwhile to distinguish ML from traditional computer-aided detection (CAD) algorithms. Traditional CAD algorithms are mathematical models that identify the presence or absence of image features known to be associated with a disease state. One of the examples is a microcalcification on a mammogram. Traditional CAD allows the developer to identify a feature explicitly and attempts to determine the presence or absence of that feature within a set of images. In contrast, ML techniques focus on a particular labeled outcome (ductal adenocarcinoma), and in the process of training, clusters of nodes evolve into algorithms for identifying features. The power and promise of the ML approach over traditional CAD is that useful features can exist that are not currently known or are beyond the limit of human detection [10]. Figure 1 shows the difference between CADe and CADx.
CADe vs. CADx. Source: Sampat et al. [
In Figure 1, ML algorithm is implemented at the segmentation, feature extraction, and classification steps. One of the most popular and powerful ML algorithm for all the steps is support vector machine (SVM). SVMs are useful for taking a large number of features and discriminating inputs into one of two classes. SVMs, once trained, show the line or border that provides the greatest margin of separation. This concept can be extrapolated to a larger number of features (or dimensions), whereby the line of separation becomes an irregular plane known as a hyperplane. Because of the large number of features that can be combined mathematically, SVMs have been found useful for image processing. This chapter is focusing on SVMs for both CADe for radiology and CADx for pathology diagnostics.
Digital medical image recognition (DMIR) might give a promising solution. DMIR is considered as an essential aspect of artificial intelligence. DMIR techniques aim to extract specific information from medical images to assist doctors in diagnosing certain diseases and follow their progress. Many image processing techniques have been utilized in DMIR, such as segmentation, object detection, and classification. DMIR is concerned with numerous imaging modalities in the field of diagnosis including computed tomography (CT), digital mammography, magnetic resonance imaging (MRI), and microscopic histopathological images [16, 17]. Depending on the type of breast tissue, breast mass appears different in a mammogram. While it appears as solid block in dense breast, it appears as a roundish pie in a fatty breast. The mass may be alone or with microcalcifications [1]. In some cases, healthy breasts are also diagnosed as suspicious of cancer by the radiologist, and unfortunately, unnecessary biopsy is performed on them. Knowing that there are many possibilities of masses in breast cancer, detecting these features and localizing them are important. In general, localizing the mass is important in computer-aided detection, where it searches for the location in the mammogram images and segments it. Refs. [1, 18] examine the most important approaches used for mass segmentation in mammogram. In general, localizing the mass is important in computer-aided detection where it searches for the location in the mammogram images and do segmentation. Cheng et al. [18] examine the most important approaches used for mass segmentation in mammogram. Image segmentation using thresholding is the simplest way to isolate the object from its background when the image has a distinct gray level distribution. Segmentation separates the regions by assuming that the region that have gray levels below a specific value, called the threshold, as a background and the region with gray levels higher than the threshold as the object or vice versa. Identifying the threshold value is the key point in this algorithm. By selecting a representable threshold, object extraction will be more accurate. Mostly, image histogram is used to identify the threshold value. Mass localization method is discussed in this chapter. This section is based on our previous work on SVM rejection model for breast cancer. This method is a rejection model based on SVM algorithm used to reduce the FP of the output of the Chan-Vese segmentation algorithm that was initialized by the MCWS algorithm.
Abnormal findings on screening mammograms lead to recall for further assessment, which includes additional imaging procedures and if considered necessary fine needle aspiration cytology, core needle biopsy, or surgical biopsy. Women recalled for further assessment without having a breast cancer diagnosed are considered to have had a FP screening result. FP results are a concern of mammographic screening as they might cause distress, anxiety, and other psychological problems to the women [19, 20]. It also implies additional hospital visits and diagnostic tests, as well as additional costs [21, 22]. The rates of FP screening results depend on the screening performance and organization, such as the screening interval, single versus double reading, participation patterns, sensitivity of the radiologists performance, equipment, and characteristics related to the screening population [22, 23, 24, 25, 26]. From image segmentation perspective, the FP is an over-segment result where the noncancerous pixel is segmented as a cancer pixel. The FP rate is considered a challenge in localizing masses in mammogram images. Hence, in this section, a rejection model is proposed by using SVM.
The goal of the rejection model which is based on SVM is the reduction of FP rate in segmenting mammogram through the Chan-Vese method, which is initialized by the MCWS algorithm. The MCWS algorithm is utilized for segmentation of a mammogram image. The segmentation is subsequently refined through the Chan-Vese method, followed by the development of the proposed SVM rejection model with different window size as well as its application in eliminating incorrect segmented nodules MCWS algorithm. SVM rejection model consists of three important stages: (i) initial segmentation, (ii) segmentation using Chan-Vese, and (iii) refined segmentation using SVM rejection model. First, the source image is cropped to remove any unnecessary parts in an image. Based on the high dimensionality in digital mammogram images, the image is then resized to speed up the subsequent processes. Second, completing the pre-processing stage, the SVM rejection model is built to reduce the FP rate. Presegmentation and postsegmentation enhancement for Chan-Vese level set algorithm is then proposed to localize masse in the mammogram. The key to achieve a good segmentation result using Chan-Vese is the initial contour. Instead of getting the initial contour from the expert, here, MCWS algorithm is used to obtain the initial contour, as well as to eliminate the noise. This makes the proposed method fully automated and reduces the time of interference. Lastly, localization of mass in mammogram, Chan-Vese active contour-based algorithm was used. Chan-Vese can find and maximize the convergence ranges, as well as treat the topological change. This ensures that Chan-Vese performs well in image segmentation. Support vector machine is a learning machine algorithm expounded by Cortes and Vapnik [15] at the AT&T Bell Laboratories that strives to address the issues pertaining to a two-group classification. The underlying working principle of this algorithm is to search for the optimal hyperplane that sets positive classes (+1) apart from negative classes (−1). In this context, the two classes are the nodules and the nonnodules of breast images, of which the provided training data were used for the SVM to build a model in predicting the target values of the two test data attributes. In this work, the radial basis function (RBF) kernel is employed in complementary with the SVM. The two best parameters, C and γ, are prerequisites for the generation of an accurate breast nodule and nonnodule classification by the RBF kernel. The SVM rejection model has three phases: extracting teacher image, training, and testing as shown in Figure 2. The grid has been used as a straightforward search on the training data to find the best parameters, and the reason for using the grid search instead of other search algorithms is because of its short computation time. Additionally, the grid search can be easily parallelized because it is independent. The search spaces used in this research are [2⁻5, 210]. It is important to note that this study used the strategy of dividing the data set into two parts, of which one is considered unknown. The prediction accuracy obtained from the unknown set will reflect on the classification performance of the independent data set. This procedure is known as cross validation. Its goal is to divide the training set into v subsets of equal size. One subset will be tested using the classifier trained on the remaining subsets. Subsequently, each instance of the training set will be predicted once. This is to ensure that the cross-validation accuracy is the percentage of data that have been correctly classified. The training data (teacher images) for the rejection model were manually extracted from the mammogram images by analyzing the false positives (FP) and true positives (TP) of the Chan-Vese segmentation result. After the teacher images were extracted, they were resized using the same factor for the original image. Next, depending on the window size that considered the number of inputs to SVM rejection model, the teacher image was resized. Based on the experiment, either a window size of (7 × 7), (9 × 9), (11 × 11), or (13 × 13) was taken into consideration. After that, the image was transferred to a vector and then written into the training data file. This file contained two variables, x and y. The first variable x is a matrix containing rows of window pixel values for the teacher images. Each row represented one image. The length of the rows depended on the window size. The number of rows in this variable depended on the number of teacher images. The other variable y is a vector containing the class for each image. The class may be “1” for nodule images or “0” for nonnodule images. Before proceeding with the SVM rejection training, training data were used to obtain the best values for parameters C, γ. As previously mentioned, the grid search was used as a straightforward search on the training data to obtain these values. Cross validation was also applied to spill the training data 10-fold into training and testing. Depending on the best accuracy value returned by SVM, the best C and best γ values were chosen. The SVM rejection model was built using the selected C and γ values and the training data set.
The process of SVM rejection model.
Based on model in Figure 2, each row in the training data (
About 170 mammogram images from 109 patients were collected from the UKM Medical Centre (UKMMC). Table 1 and Figure 3 show training and testing data that have been used in the experiment. The teacher images extracted from the training data based on the segmentation result contained 35 nodule images and 35 nonnodule images extracted from the training data set. The SVM rejection model was run 10 times with a standard deviation of 0.0001, and the results showed the effectiveness of using the rejection model compared with the ground truth. As mentioned earlier, the grid search was used as a straightforward search on the training data to determine the best parameters C, γ. Table 2 shows values of C, γ using various window sizes (7 × 7), (9 × 9), (11 × 11), and (13 × 13).
Training data | Testing data | |||
---|---|---|---|---|
Nodule | Nonnodule | Nodule | Nonnodule | |
Number of images | 11 | 17 | 46 | 96 |
Total number of images | 28 | 142 |
Data set for training and testing.
Hierarchy of UKMMC data set.
Result (predicted) | ||
---|---|---|
Nodule pixel | Nonnodule pixel | |
Ground truth (actual) | ||
Nodule pixel | TP | FN |
Nonnodule pixel | FP | TN |
Confusion matrix.
Accuracy denotes the proportion of the correct result and it can be calculated as shown in the following Eqs. (1)–(7), where TP is true positives, TN is true negatives, FP is false positives (type 1 error), and FN is false negatives (type 2 error). In mass localization, the concept of the confusion matrix that is in Table 2 represents the correctly segmented nodule and nonnodule with the miss segment. TP and TN are the correctly localized nodule and nonnodule, respectively, while FP is the incorrectly segmented nonnodule as a nodule and FN is incorrectly segmented nodule as a nonnodule.
Specificity is also known as TN rate, and it represents the ability of the method to identify the nonnodule and avoiding false positives.
Sensitivity, which is also known as TP rate or recall, represents the ability to identify the nodule and avoid false negatives.
The FP rate shows the nonnodule pixel, which is segmented as nodule. It is an over segmented pixel. The FN rate shows the nodule pixel, which is segmented as nonnodule. It is the miss segmented.
The NRM shows the mismatch between the predicted results and the actual ground truth. Our method was evaluated by comparing the segmented images to the ground truth. To show the effectiveness of the method, a comparison was done before and after the rejection model, as shown in Figure 4. This process was performed first by comparing each pixel in the resulting image with the corresponding pixel in the ground truth image. Then, objective evaluation was used to evaluate the method by calculating the confusion matrix as in Table 2, based on the prediction result and the actual ground truth. Table 3 and Figure 4 show the quantitative analysis of the results and sample of the result. The effectiveness of our method can be proven by comparing the result before and after using the rejection model. Table 3 shows the FP rate of the rejection model is inversely proportionate to the window size. On the other hand, the specificity rate of the rejection model is linearly proportional to window size.
Result before and after using SVM model. (a1, b1, c1, and d1) original nonnodule and nodule images. (a2, b2, c2, and d2) segmentation result without using SVM rejection model, (a3, b3, c3, and d3) segmentation result after reducing the FP rate using SVM rejection model, (a4, b4, c4, and d4) ground truth images,. (a5, b5, c5, and d5) binary segmentation result without using SVM rejection model (a6, b6, c6, and d6) binary segmentation result after reducing the FP rate using SVM rejection model (a7, b7, c7, and d7) ground truth images.
FP rate | SP | AC | NRM | OVERLAP | |
---|---|---|---|---|---|
Without the rejection model | 0.196 | 0.803 | 0.803 | 0.099 | 0.800 |
With the rejection Model (7 × 7 × 7 × 7) | 0.058 | 0.941 | 0.938 | 0.031 | 0.933 |
With the rejection model (9 × 9 × 9 × 9) | 0.051 | 0.948 | 0.944 | 0.028 | 0.940 |
With the rejection model (11 × 11 × 11 × 11) | 0.044 | 0.955 | 0.950 | 0.025 | 0.946 |
With the rejection model (13 × 13 × 13 × 13) | 0.040 | 0.959 | 0.954 | 0.023 | 0.950 |
Quantitative analysis.
This section discussed on reducing the FP rate based on SVM machine learning. The SVM rejection model was built to reduce the FP rate after segmentation. Our method has three steps in the segmentation phase: first, MCWS was used to obtain the initial contour by segmenting the mammogram image. Then, the output of MCWS was used as an initial contour to the Chan-Vese algorithm. Finally, the rejection model based on SVM was used in order to reduce the FP rate. The SVM rejection model has three steps in the following order: extracting teacher images, training the rejection model, and testing the model. The FP rate reduction by means of SVM machine learning been put forth, wherein the FP rate, upon segmentation, had been reduced by the developed SVM rejection model. The segmentation of the mass in mammogram images as well as the extraction of the initial contour was performed through MCWS, of which the proposed method comprises. The Chan-Vese algorithm is employed as the initial contour to enhance the result of the segmentation. The three steps of the SVM rejection model are in the following sequence: extracting teacher images, training the rejection model, and testing the model. Credence can be given to the MCWS algorithm in surmounting the challenges associated with the Chan-Vase algorithm. The Chan-Vese algorithm can be made more autonomous and converge faster by using a good initialization generated by MCWS.
Nevertheless, the reliance mammogram segmentation on the divergence and convergence of the intensity value of the image pixels is the constraint factor for this algorithm. The tendency has been toward segmenting the outlier component as part of the contour component, resulting in an incremental FP rate of the selected contour pixels. Accordingly, to overcome this issue, the SVM rejection model is geared toward reducing the FP rate. T-test was performed to determine the mean difference of two samples, that is, the accuracy before and after using rejection model with the best window size, which is (13 × 13). The T-test was applied to determine if there was a difference before and after applying the rejection model. The hypothesized mean difference of T-test was set to value 0, also named as null hypothesis. That means, assuming that there was no difference in the result whether using the rejection model. The alpha was set to value 0.05. The concept of T-test states that if the P value is less than the assumed alpha, the null hypothesis is not correct and there is a difference between the mean of the two samples. T-test result shows that the proposed method is considered statistically significant with (P = 0.00001 < 0.05). Furthermore, the proposed rejection models also showed less standard deviation (0.0001) and yields to stability in its performance. In general, this proposed method offers alternative decision-making ability and is able to assist the medical expert in giving second opinion on more precise nodule detection. Hence, it reduces FP rate that causes over segmentation.
This section focuses on the histopathological grading step in the breast diagnosis, the procedure used to grade a certain tissue by examining the tissue slide biopsy, which must undergo a preparation step prior to the grading.
Breast tissue biopsy is a piece of tumorous tissue taken from the breast to investigate the occurrence of cancer. After the biopsy is extracted, it is enclosed in a fixative to prevent it from decaying. Then, the tissue is sectioned into fragile slices (e.g., 2–15 μm) using a microtome machine, which creates very thin slices. The slices are then arranged on the glass slide before being stained. The tissue is stained using certain pigments to reveal the tissue components (e.g., lumen, nuclei, cytoplasm, and stroma). This helps the pathologist to view the individual tissue component more clearly. This procedure is called cells marker. The pathologists use different methods of staining depending on the diagnostic process at hand. Among the common staining types, Hematoxylin and Eosin combination H&E is the most popular for diagnosis and grading. After staining the tissue slide, the pathologist evaluates the tissue slide using the microscope as in UKMMC or through a digital scanner used to produce digital pathology images. In UKMMC, a specific type of microscope (Olympus BX50 microscope) is used for the diagnosis [16]. This microscope has a camera to capture images of the region of interest. The next subsection will explain the image acquisition steps involved in the creation of the prostate and breast cancer data sets required for this study. Subsequent subsections will present a brief overview of the devices required for the image acquisition and image acquisition flow.
In this study, prostate histological images were captured from tissue slides. All the images were viewed using an Olympus BX50 microscope (Olympus Corporation, Japan), and images were captured using a DP72 digital camera (Olympus Corporation) and cellSens Life Science imaging software, version 1.6 (Olympus Corporation) [16]. The sensitivity of the illumination source and camera’s intensity were kept constant. The microscopes were adjusted manually to form clear magnified images, and the cameras were controlled through desktop computers to capture color digital images. Before image acquisition, the pathologists in UKMMC had selected the ROIs under the microscope. However, this requires substantial time and effort from pathologists, and more importantly, a subjective choice of the ROIs could introduce biases into the database and harm the generalizability of the developed computer CAD system.
Prior to acquiring the images, the microscope components, such as the light condenser, diffusing screen, and objective lens, were properly cleaned to remove any dust in the light path, which might badly affect the clarity of the acquired image. The focal plane was adjusted manually for clear images and was readjusted before every new image was taken. A light condenser was used to increase the light intensity for high-resolution image acquisition. To acquire an image from an ROI, the pathologist in UKMMC first reviewed the tissue section at a low magnification (e.g., 1× or 4×) to locate the ROI at the center of the image’s field of view [16]. Usually, fine tuning is needed at higher magnification (40× magnification) to ensure a region with a typical Gleason pattern in the ROI is selected. The focal plane was then adjusted to produce a sharp image, and the light intensity was tuned so that the largest pixel value was slightly lower than the upper limit of the pixel’s dynamic range. When all those adjustments were satisfactory, a still image was captured and saved onto the desktop computer as a color RGB digital image with a (tiff) extension. This process was repeated for all images that were captured for breast pathologists.
This data set contains self-collected breast tissue region images stained using the H&E procedure and captured from tissue slides of needle biopsies taken from 32 breast carcinoma cases. These tissue region images were digitized at 40× magnification, yielding high resolution images (4140 × 3096 pixels) in (tiff) format. The diagnosis assigned to each region image is based on the Bloom–Richardson grading system [16]. Each image was annotated as low grade (Grade 1) or high grade (Grade 3) by three expert pathologists from the HUKM center [16]. The total number of collected images is 100. These can be classified into 56 low-grade cases and 54 high-grade cases. Figure 5 shows some sample images taken from this data set.
Ensemble framework for breast tissue image diagnosis and grading.
This section explains the ensemble framework that we used for the classification of breast cancer and Gleason grading using the tissue components of the H&E histopathological region images. This project has been carried out from our previous work [16]. The framework is based on the ensemble learning approach from machine learning and medical tissue components (lumen, nuclei, cytoplasm, and stroma), both of which are of semantic meanings to pathologists. The framework extracts a set of textural features for each tissue component, which creates four independent sub data sets, and the diversity demonstrated by these data sets is then used to create an ensemble framework that is able to classify and grade breast cancer. Our framework consists of five phases: segmentation of four tissue components, feature extraction, feature selection, base classifiers of the framework, and ensemble fusion phase, as per Figure 5.
The typical CAD for breast cancer grading extracts features directly from histopathological images. Then, a single classifier is used to train these features to classify unknown patterns (e.g., image). Unlike this typical CAD, our project uses the concept ensemble learning (Figures 5 and 6).
Two types of tissue classes of interest for the breast grading problem: (a) Grade 1 (low grade) tissue and (b) Grade 3 (high grade) tissue.
Due to the diversity of the tissue components, four different training data sets are created for the corresponding tissue components (lumen, nuclei, cytoplasm, and stroma). Thus, the diversity of the tissue components in ensemble learning is utilized to improve prostate diagnosis and grading. In this project, the ensemble framework, consisting of four-base SVM (RBF) classifiers, where each base classifier is a specialist, is trained to use the selected features of a particular tissue component. The decision function of SVM (RBF) with the top selected features (Ω) in the training model is defined as per (Eq. (7)):
where 𝑥Ω is the test sample with only Ω corresponding features, 𝑥Ω,
In the ensemble framework, the stages of feature selection and classification are executed 50 times for each classification task. In each run, the data set of each base classifier (i.e., tissue component) is randomly divided into 50% training and 50% testing) after normalizing, as per [16]. It should be pointed out that in each run of the ensemble framework, similar numbers of selected features are used with all base classifiers. The base classifiers utilize the SVM with Radial-Basis-Function (RBF) kernel, while the SVM-RFE utilizes the linear SVM. To deploy RBF, one needs to set an appropriate value of the cost penalty, c, and gamma,
Classification task Breast UKM | Measure | Proposed ensemble framework | Naïve approach | Typical CAD [22] | Significant of ensemble with | |
---|---|---|---|---|---|---|
Naive | Typical CAD [22] | |||||
Low vs. high grade | AUC | 90.7 ± 5.0 | 89.9 ± 4.8 | 89.8 ± 3.9 | — | — |
Accuracy | 90.8 ± 5.0 | 89.9 ± 4.8 | 89.8 ± 3.9 | — | — | |
Sensitivity | 87.11 ± 8.4 | 87.1 ± 8.8 | 88.5 ± 7.7 | — | — | |
Specificity | 94.3 ± 5.3 | 92.7 ± 6.3 | 91.1 ± 6.9 | — | — |
The performance of the proposed ensemble framework on breast histopathology images data set.
This chapter discusses how machine learning, particularly SVM can improve the performance for detection and diagnosing of breast cancer. SVM for now is one of the most powerful machine learning techniques that is able to model the human understanding of classifying data. It can find the relationship between data and segregates them accordingly. Using pixel values in mammogram images, SVM helps to improve the mass detection and segmentation of Chan-Vese algorithms by classifying correctly the false positive pixels. As a result, a sharper mass was detected with better estimation of its shapes and sizes. Hence, radiologist can give better diagnosis and biopsy location. Then, images of cell structure or tissue textures from the biopsy sample were examine by the pathologist. These pathology slides were analyzed under the pathologist sharp eyes to locate and identify any abnormal pattern of tissue texture or architecture. The process is tiring and subjective to the pathologist experience in interpreting the tissue condition. Thus, inter-observer and intra-observer variations exist. However, the proposed SVM algorithm can identify the different tissue component and model the pattern of relationship between these components spatially and statistically. The model is then used to grade any new pathology slides into its modified Bloom-Richardson grading, according to what the SVMs have learned from previous examples. Using the technique, it helps the radiologist and pathologist reducing their work load by automating the automation for decision making, especially for common and mundane cases. Radiologist and pathologist would have more time to spend on special or rare cases. The learning curve for young apprentice can be steeper. The automate grading of breast cancer helps to reduce the variation of inter- and intra-observation by the pathologist. In our work, it should be noted that we are not using the identical patient data of mammogram and pathology due to some limitation. However, in the future it is possible to take the identical patient. Via the automatic decision making we are able to create a platform that integrate diagnostic reporting system that supports both specialties and, therefore, improves the overall quality of patient care (Figure 7).
Single vs. ensemble classification results for low vs. high grade.
However, combining these tissue components’ features resulted in dense feature vectors, which suffers from overfitting. The use of the ensemble learning framework that allows prediction using several training subsets could help mitigate this problem. These different subsets are clearly shown in the proposed ensemble framework. The results indicate that proposed ensemble framework significantly outperformed the typical CAD, naïve approach, and structure-based method.
The authors thank the Faculty of Information Science and Technology, Universiti Kebangsaan Malaysia, for providing the facilities and financial support under “ETP-2013-053 diagnostic services nexus for breast cancer.” Gratitude is also due to Human Life Advancement Foundation (HLAF) for its financial support. Ethics approval was obtained entitled “FF-338-2012 Breast Cancer Diagnostic Imaging System Using Mammogram and Ultrasound” from UKM Medical Center, Malaysia, for collecting and studying breast cancer patient records.
.
",metaTitle:"Order Print Copies - Terms",metaDescription:".",metaKeywords:null,canonicalURL:"page/order-print-copies-terms/",contentRaw:'[{"type":"htmlEditorComponent","content":"Orders have to be prepaid in advance and before printing. We accept payment in GBP, EUR and USD. Payments can be made by bank transfer or cheque, by credit card (Visa, MasterCard, American Express, Discover Card) and PayPal worldwide online payments system. In accordance with the best security practice, we do not accept card orders via email.
\\n\\nThe combined printing and delivery times for orders vary from 12-20 business days, depending on the printed quantity and destination. This period does not include any customs clearance difficulties that may arise and that are beyond our control. Once your order has been printed and shipped, you will receive a confirmation email that includes your DHL tracking number. You can then track your order at www.dhl.com.
\\n\\nMy order has not arrived, what do I do?
\\n\\nIf you do not receive your order within 30 days, please contact us to inquire about the shipping status at orders@intechopen.com.
\\n\\nPOD products are non-returnable and non-refundable, except in the event of poor print quality or an error in quantity. If we delivered the item to you in error or the item is faulty, please contact us. Inspect your order carefully when it arrives. Any problems should be immediately reported to orders@intechopen.com.
\\n\\nTaxes: Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing us their VAT registration number. This is made possible by the EU reverse charge method.
\\n\\nCustoms: Shipping costs do not include any duties, taxes or clearing charges levied by the destination country. These charges are the responsibility of the customer and will vary from country to country.
\\n"}]'},components:[{type:"htmlEditorComponent",content:'Orders have to be prepaid in advance and before printing. We accept payment in GBP, EUR and USD. Payments can be made by bank transfer or cheque, by credit card (Visa, MasterCard, American Express, Discover Card) and PayPal worldwide online payments system. In accordance with the best security practice, we do not accept card orders via email.
\n\nThe combined printing and delivery times for orders vary from 12-20 business days, depending on the printed quantity and destination. This period does not include any customs clearance difficulties that may arise and that are beyond our control. Once your order has been printed and shipped, you will receive a confirmation email that includes your DHL tracking number. You can then track your order at www.dhl.com.
\n\nMy order has not arrived, what do I do?
\n\nIf you do not receive your order within 30 days, please contact us to inquire about the shipping status at orders@intechopen.com.
\n\nPOD products are non-returnable and non-refundable, except in the event of poor print quality or an error in quantity. If we delivered the item to you in error or the item is faulty, please contact us. Inspect your order carefully when it arrives. Any problems should be immediately reported to orders@intechopen.com.
\n\nTaxes: Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing us their VAT registration number. This is made possible by the EU reverse charge method.
\n\nCustoms: Shipping costs do not include any duties, taxes or clearing charges levied by the destination country. These charges are the responsibility of the customer and will vary from country to country.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6581},{group:"region",caption:"Middle and South America",value:2,count:5888},{group:"region",caption:"Africa",value:3,count:2381},{group:"region",caption:"Asia",value:4,count:12507},{group:"region",caption:"Australia and Oceania",value:5,count:1006},{group:"region",caption:"Europe",value:6,count:17528}],offset:12,limit:12,total:132501},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"-dateEndThirdStepPublish"},books:[{type:"book",id:"9985",title:"Geostatistics",subtitle:null,isOpenForSubmission:!0,hash:"423cb3896195a618c4acb493ce4fd23d",slug:null,bookSignature:"Prof. Jeffrey M. Yarus, Dr. Marko Maucec, Dr. Timothy C. Coburn and Associate Prof. Michael Pyrcz",coverURL:"https://cdn.intechopen.com/books/images_new/9985.jpg",editedByType:null,editors:[{id:"78011",title:"Prof.",name:"Jeffrey M.",surname:"Yarus",slug:"jeffrey-m.-yarus",fullName:"Jeffrey M. Yarus"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12144",title:"Mycorrhiza - New Insights",subtitle:null,isOpenForSubmission:!0,hash:"dddc237ff52d11c9acbfbd488686336b",slug:null,bookSignature:"Dr. Rodrigo De Sousa",coverURL:"https://cdn.intechopen.com/books/images_new/12144.jpg",editedByType:null,editors:[{id:"297508",title:"Dr.",name:"Rodrigo",surname:"De Sousa",slug:"rodrigo-de-sousa",fullName:"Rodrigo De Sousa"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12176",title:"Oligonucleotides - Overview and Applications",subtitle:null,isOpenForSubmission:!0,hash:"365b4a84e87d26bcb24b7183814fba04",slug:null,bookSignature:"Dr. Arghya Sett",coverURL:"https://cdn.intechopen.com/books/images_new/12176.jpg",editedByType:null,editors:[{id:"301899",title:"Dr.",name:"Arghya",surname:"Sett",slug:"arghya-sett",fullName:"Arghya Sett"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11757",title:"Nanorods - Synthesis, Properties, Toxicity and Applications",subtitle:null,isOpenForSubmission:!0,hash:"fb27f444442e8f039b560beae93e6873",slug:null,bookSignature:"Prof. Tejendra Kumar Gupta",coverURL:"https://cdn.intechopen.com/books/images_new/11757.jpg",editedByType:null,editors:[{id:"345089",title:"Prof.",name:"Tejendra Kumar",surname:"Gupta",slug:"tejendra-kumar-gupta",fullName:"Tejendra Kumar Gupta"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12043",title:"Biodegradation - New Insights",subtitle:null,isOpenForSubmission:!0,hash:"8241477a4a935c8c292902d2768f4581",slug:null,bookSignature:"Dr. Vasudeo Zambare and Dr. Mohd Fadhil Md Din",coverURL:"https://cdn.intechopen.com/books/images_new/12043.jpg",editedByType:null,editors:[{id:"174690",title:"Dr.",name:"Vasudeo",surname:"Zambare",slug:"vasudeo-zambare",fullName:"Vasudeo Zambare"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11848",title:"Immunosuppression and Immunomodulation",subtitle:null,isOpenForSubmission:!0,hash:"ed8e45c9b1a36b2e913208c4d37dbc7f",slug:null,bookSignature:"Dr. Rajeev K. Tyagi, Dr. Prakriti Sharma and Dr. Praveen Sharma",coverURL:"https://cdn.intechopen.com/books/images_new/11848.jpg",editedByType:null,editors:[{id:"201069",title:"Dr.",name:"Rajeev",surname:"Tyagi",slug:"rajeev-tyagi",fullName:"Rajeev Tyagi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12178",title:"Hemiptera - Recent Updates",subtitle:null,isOpenForSubmission:!0,hash:"daf49271b1a1a8fe6ca15063ba065765",slug:null,bookSignature:"Dr. Hamadttu El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/12178.jpg",editedByType:null,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",surname:"El-Shafie",slug:"hamadttu-el-shafie",fullName:"Hamadttu El-Shafie"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11815",title:"Pediatric Oral Health - New Insights",subtitle:null,isOpenForSubmission:!0,hash:"e55e88cf5885a68cdf470925b35cbbd8",slug:null,bookSignature:"Prof. Mandeep Singh Virdi",coverURL:"https://cdn.intechopen.com/books/images_new/11815.jpg",editedByType:null,editors:[{id:"89556",title:"Prof.",name:"Mandeep",surname:"Virdi",slug:"mandeep-virdi",fullName:"Mandeep Virdi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12206",title:"Antibiotic Resistance - New Insights",subtitle:null,isOpenForSubmission:!0,hash:"708d9c997d91bdbe75c55cb5d9f7b526",slug:null,bookSignature:"Dr. Ghulam Mustafa",coverURL:"https://cdn.intechopen.com/books/images_new/12206.jpg",editedByType:null,editors:[{id:"298756",title:"Dr.",name:"Ghulam",surname:"Mustafa",slug:"ghulam-mustafa",fullName:"Ghulam Mustafa"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11447",title:"Swarm Intelligence - Recent Advances and Current Applications",subtitle:null,isOpenForSubmission:!0,hash:"f68e3c3430a74fc7a7eb97f6ea2bb42e",slug:null,bookSignature:"Dr. Marco Antonio Aceves Fernandez",coverURL:"https://cdn.intechopen.com/books/images_new/11447.jpg",editedByType:null,editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11521",title:"Internal Combustion Engines - Recent Advances",subtitle:null,isOpenForSubmission:!0,hash:"99cc881bcb3efe05085f2728ccbeab6b",slug:null,bookSignature:"Prof. Akaehomen Akii Ibhadode",coverURL:"https://cdn.intechopen.com/books/images_new/11521.jpg",editedByType:null,editors:[{id:"253342",title:"Prof.",name:"Akaehomen",surname:"Ibhadode",slug:"akaehomen-ibhadode",fullName:"Akaehomen Ibhadode"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11896",title:"Stoichiometry - New Findings and Advances",subtitle:null,isOpenForSubmission:!0,hash:"6b32a0fe0d3c175fa3982d3836fc422b",slug:null,bookSignature:"Dr. Brajesh Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/11896.jpg",editedByType:null,editors:[{id:"176093",title:"Dr.",name:"Brajesh",surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:42},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:11},{group:"topic",caption:"Business, Management and Economics",value:7,count:6},{group:"topic",caption:"Chemistry",value:8,count:21},{group:"topic",caption:"Computer and Information Science",value:9,count:20},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:60},{group:"topic",caption:"Environmental Sciences",value:12,count:8},{group:"topic",caption:"Immunology and Microbiology",value:13,count:10},{group:"topic",caption:"Materials Science",value:14,count:27},{group:"topic",caption:"Mathematics",value:15,count:9},{group:"topic",caption:"Medicine",value:16,count:123},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:9},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:7},{group:"topic",caption:"Physics",value:20,count:11},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:4},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:411},popularBooks:{featuredBooks:[{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10222",title:"Demyelination Disorders",subtitle:null,isOpenForSubmission:!1,hash:"b6c26ceccacdde70c41c587361bd5558",slug:"demyelination-disorders",bookSignature:"Stavros J. Baloyannis, Fabian H. Rossi and Welwin Liu",coverURL:"https://cdn.intechopen.com/books/images_new/10222.jpg",editors:[{id:"156098",title:"Emeritus Prof.",name:"Stavros J.",middleName:"J.",surname:"Baloyannis",slug:"stavros-j.-baloyannis",fullName:"Stavros J. Baloyannis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10979",title:"Parenting",subtitle:"Challenges of Child Rearing in a Changing Society",isOpenForSubmission:!1,hash:"6f345ebcf4fd61e73643c69063a12c7b",slug:"parenting-challenges-of-child-rearing-in-a-changing-society",bookSignature:"Sayyed Ali Samadi",coverURL:"https://cdn.intechopen.com/books/images_new/10979.jpg",editors:[{id:"52145",title:"Dr.",name:"Sayyed Ali",middleName:null,surname:"Samadi",slug:"sayyed-ali-samadi",fullName:"Sayyed Ali Samadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10764",title:"Antenna Systems",subtitle:null,isOpenForSubmission:!1,hash:"2fbf1c7a5d92723f08198fc9b526a8ad",slug:"antenna-systems",bookSignature:"Hussain Al-Rizzo and Said Abushamleh",coverURL:"https://cdn.intechopen.com/books/images_new/10764.jpg",editors:[{id:"153384",title:"Prof.",name:"Hussain",middleName:null,surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,isOpenForSubmission:!1,hash:"55856c6a8bc3a5b21dae5a1af09a56b6",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,isOpenForSubmission:!1,hash:"176adcf090fdd1f93cb8ce3146e79ca1",slug:"reactive-oxygen-species",bookSignature:"Rizwan Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10351",title:"Enhanced Liposuction",subtitle:"New Perspectives and Techniques",isOpenForSubmission:!1,hash:"f08ed6de16da357614586c5b58ed4dfa",slug:"enhanced-liposuction-new-perspectives-and-techniques",bookSignature:"Diane Irvine Duncan",coverURL:"https://cdn.intechopen.com/books/images_new/10351.jpg",editors:[{id:"279869",title:"Dr.",name:"Diane Irvine",middleName:null,surname:"Duncan",slug:"diane-irvine-duncan",fullName:"Diane Irvine Duncan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10779",title:"21st Century Nanostructured Materials",subtitle:"Physics, Chemistry, Classification, and Emerging Applications in Industry, Biomedicine, and Agriculture",isOpenForSubmission:!1,hash:"72c67f97f9bef68200df115b5fd79884",slug:"21st-century-nanostructured-materials-physics-chemistry-classification-and-emerging-applications-in-industry-biomedicine-and-agriculture",bookSignature:"Phuong V. Pham",coverURL:"https://cdn.intechopen.com/books/images_new/10779.jpg",editors:[{id:"236073",title:"Dr.",name:"Phuong",middleName:"Viet",surname:"Pham",slug:"phuong-pham",fullName:"Phuong Pham"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4386},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",publishedDate:"April 28th 2022",numberOfDownloads:3665,editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10222",title:"Demyelination Disorders",subtitle:null,isOpenForSubmission:!1,hash:"b6c26ceccacdde70c41c587361bd5558",slug:"demyelination-disorders",bookSignature:"Stavros J. Baloyannis, Fabian H. Rossi and Welwin Liu",coverURL:"https://cdn.intechopen.com/books/images_new/10222.jpg",publishedDate:"May 4th 2022",numberOfDownloads:1713,editors:[{id:"156098",title:"Emeritus Prof.",name:"Stavros J.",middleName:"J.",surname:"Baloyannis",slug:"stavros-j.-baloyannis",fullName:"Stavros J. Baloyannis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",publishedDate:"April 28th 2022",numberOfDownloads:2481,editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10979",title:"Parenting",subtitle:"Challenges of Child Rearing in a Changing Society",isOpenForSubmission:!1,hash:"6f345ebcf4fd61e73643c69063a12c7b",slug:"parenting-challenges-of-child-rearing-in-a-changing-society",bookSignature:"Sayyed Ali Samadi",coverURL:"https://cdn.intechopen.com/books/images_new/10979.jpg",publishedDate:"May 4th 2022",numberOfDownloads:1107,editors:[{id:"52145",title:"Dr.",name:"Sayyed Ali",middleName:null,surname:"Samadi",slug:"sayyed-ali-samadi",fullName:"Sayyed Ali Samadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3307,editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3266,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10764",title:"Antenna Systems",subtitle:null,isOpenForSubmission:!1,hash:"2fbf1c7a5d92723f08198fc9b526a8ad",slug:"antenna-systems",bookSignature:"Hussain Al-Rizzo and Said Abushamleh",coverURL:"https://cdn.intechopen.com/books/images_new/10764.jpg",publishedDate:"April 28th 2022",numberOfDownloads:1868,editors:[{id:"153384",title:"Prof.",name:"Hussain",middleName:null,surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,isOpenForSubmission:!1,hash:"55856c6a8bc3a5b21dae5a1af09a56b6",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",publishedDate:"May 4th 2022",numberOfDownloads:856,editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,isOpenForSubmission:!1,hash:"176adcf090fdd1f93cb8ce3146e79ca1",slug:"reactive-oxygen-species",bookSignature:"Rizwan Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",publishedDate:"April 28th 2022",numberOfDownloads:1704,editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",publishedDate:"March 16th 2022",numberOfDownloads:7489,editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,isOpenForSubmission:!1,hash:"49cce3f548da548c718c865feb343509",slug:"rabies-virus-at-the-beginning-of-21st-century",bookSignature:"Sergey Tkachev",coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10861",title:"Furan Derivatives",subtitle:"Recent Advances and Applications",isOpenForSubmission:!1,hash:"fdfc39cecd82f91b0effac994f75c877",slug:"furan-derivatives-recent-advances-and-applications",bookSignature:"Anish Khan, Mohammed Muzibur Rahman, M. Ramesh, Salman Ahmad Khan and Abdullah Mohammed Ahmed Asiri",coverURL:"https://cdn.intechopen.com/books/images_new/10861.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"293058",title:"Dr.",name:"Anish",middleName:null,surname:"Khan",slug:"anish-khan",fullName:"Anish Khan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10870",title:"Ultrasound Imaging",subtitle:"Current Topics",isOpenForSubmission:!1,hash:"2f0bc3733ab226d67fa73759ef0e12ad",slug:"ultrasound-imaging-current-topics",bookSignature:"Felix Okechukwu Erondu",coverURL:"https://cdn.intechopen.com/books/images_new/10870.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"68312",title:"Prof.",name:"Felix",middleName:null,surname:"Okechukwu Erondu",slug:"felix-okechukwu-erondu",fullName:"Felix Okechukwu Erondu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",isOpenForSubmission:!1,hash:"86a6d33cf601587e591064ce92effc02",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10400",title:"The Application of Ant Colony Optimization",subtitle:null,isOpenForSubmission:!1,hash:"f4fdfd07ee1ab99fb7c740d6d0c144c6",slug:"the-application-of-ant-colony-optimization",bookSignature:"Ali Soofastaei",coverURL:"https://cdn.intechopen.com/books/images_new/10400.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"257455",title:"Dr.",name:"Ali",middleName:null,surname:"Soofastaei",slug:"ali-soofastaei",fullName:"Ali Soofastaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10915",title:"Leadership",subtitle:"New Insights",isOpenForSubmission:!1,hash:"0d72e79892f2a020cee66a52d09de5a4",slug:"leadership-new-insights",bookSignature:"Mário Franco",coverURL:"https://cdn.intechopen.com/books/images_new/10915.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"105529",title:"Dr.",name:"Mário",middleName:null,surname:"Franco",slug:"mario-franco",fullName:"Mário Franco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10683",title:"Technological Innovations and Advances in Hydropower Engineering",subtitle:null,isOpenForSubmission:!1,hash:"7ce7ad8768bd2cad155470fe1fd883f4",slug:"technological-innovations-and-advances-in-hydropower-engineering",bookSignature:"Yizi Shang, Ling Shang and Xiaofei Li",coverURL:"https://cdn.intechopen.com/books/images_new/10683.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"349630",title:"Dr.",name:"Yizi",middleName:null,surname:"Shang",slug:"yizi-shang",fullName:"Yizi Shang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7102",title:"Pneumonia",subtitle:null,isOpenForSubmission:!1,hash:"9fd70142814192dcec58a176749f1b60",slug:"pneumonia",bookSignature:"Nima Rezaei",coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9670",title:"Current Trends in Wheat Research",subtitle:null,isOpenForSubmission:!1,hash:"89d795987f1747a76eee532700d2093d",slug:"current-trends-in-wheat-research",bookSignature:"Mahmood-ur-Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9670.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"675",title:"Soil Chemistry",slug:"soil-chemistry",parent:{id:"108",title:"Soil Science",slug:"earth-and-planetary-sciences-soil-science"},numberOfBooks:4,numberOfSeries:0,numberOfAuthorsAndEditors:94,numberOfWosCitations:27,numberOfCrossrefCitations:35,numberOfDimensionsCitations:77,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"675",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10590",title:"Humic Substances",subtitle:null,isOpenForSubmission:!1,hash:"85786eb36b3e13979aae664a4e046625",slug:"humic-substances",bookSignature:"Abdelhadi Makan",coverURL:"https://cdn.intechopen.com/books/images_new/10590.jpg",editedByType:"Edited by",editors:[{id:"247727",title:"Prof.",name:"Abdelhadi",middleName:null,surname:"Makan",slug:"abdelhadi-makan",fullName:"Abdelhadi Makan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9843",title:"Soil Contamination",subtitle:"Threats and Sustainable Solutions",isOpenForSubmission:!1,hash:"6b175b72cb10952220515885ac49598c",slug:"soil-contamination-threats-and-sustainable-solutions",bookSignature:"Marcelo L. Larramendy and Sonia Soloneski",coverURL:"https://cdn.intechopen.com/books/images_new/9843.jpg",editedByType:"Edited by",editors:[{id:"14764",title:"Dr.",name:"Marcelo L.",middleName:null,surname:"Larramendy",slug:"marcelo-l.-larramendy",fullName:"Marcelo L. Larramendy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8123",title:"Metals in Soil",subtitle:"Contamination and Remediation",isOpenForSubmission:!1,hash:"5bf06fb97dff16934a2319d873089ec6",slug:"metals-in-soil-contamination-and-remediation",bookSignature:"Zinnat Ara Begum, Ismail M. M. Rahman and Hiroshi Hasegawa",coverURL:"https://cdn.intechopen.com/books/images_new/8123.jpg",editedByType:"Edited by",editors:[{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6076",title:"Soil pH for Nutrient Availability and Crop Performance",subtitle:null,isOpenForSubmission:!1,hash:"173305a5e0ae12b94fd56c04957acbdd",slug:"soil-ph-for-nutrient-availability-and-crop-performance",bookSignature:"Suarau Oshunsanya",coverURL:"https://cdn.intechopen.com/books/images_new/6076.jpg",editedByType:"Edited by",editors:[{id:"175778",title:"Dr.",name:"Suarau",middleName:null,surname:"Oshunsanya",slug:"suarau-oshunsanya",fullName:"Suarau Oshunsanya"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:4,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"64054",doi:"10.5772/intechopen.81223",title:"Metal-Contaminated Soil Remediation: Phytoremediation, Chemical Leaching and Electrochemical Remediation",slug:"metal-contaminated-soil-remediation-phytoremediation-chemical-leaching-and-electrochemical-remediati",totalDownloads:1903,totalCrossrefCites:4,totalDimensionsCites:15,abstract:"Soil contamination has led to serious land tenure problems, reduction in land usability for agricultural production; as a consequence, food insecurity is nowadays a global challenge. Indeed, with rapid population growth across the world, the food demand for consumption has drastically increased and traditional ways of producing food cannot meet with the actual demand. Industrialization has been acknowledged as a way out to sustain humanity with food. Unfortunately, the later has further turn into a threat to the environment. In effect, several potentially toxic elements (PTE) are being released in the environment and soil systems; and arable or agricultural lands are getting restraint, limited and scarce. Nowadays, there is a consensus on remediating contaminated lands with PTE, mainly inorganic contaminants, metals. The state at which a metal is found in the soil greatly influences its bioavailability, interaction with plants and the level at which it will threaten (toxicity) the environment and thus human. It even defines the remediation approaches to be applied for the soil restoration. This chapter will provide an insight on the occurrence of PTE in the soil, bioavailability and remediation approaches namely phytoremediation, chemical leaching and electrochemical remediation; and finally highlight the future research direction on this topic.",book:{id:"8123",slug:"metals-in-soil-contamination-and-remediation",title:"Metals in Soil",fullTitle:"Metals in Soil - Contamination and Remediation"},signatures:"Binessi Edouard Ifon, Alexis Crépin Finagnon Togbé,\nLyde Arsène Sewedo Tometin, Fidèle Suanon and Arouna Yessoufou",authors:[{id:"257187",title:"Dr.",name:"Fidèle",middleName:null,surname:"Suanon",slug:"fidele-suanon",fullName:"Fidèle Suanon"},{id:"263966",title:"MSc.",name:"Binessi Edouard",middleName:null,surname:"Ifon",slug:"binessi-edouard-ifon",fullName:"Binessi Edouard Ifon"},{id:"263968",title:"Dr.",name:"Arouan",middleName:null,surname:"Yessoufou",slug:"arouan-yessoufou",fullName:"Arouan Yessoufou"},{id:"267945",title:"Dr.",name:"Alexis Finagnon Crepin",middleName:null,surname:"Togbe",slug:"alexis-finagnon-crepin-togbe",fullName:"Alexis Finagnon Crepin Togbe"},{id:"267946",title:"Dr.",name:"Lyde A.S.",middleName:null,surname:"Tomètin",slug:"lyde-a.s.-tometin",fullName:"Lyde A.S. Tomètin"}]},{id:"63832",doi:"10.5772/intechopen.81348",title:"The Influence of Potentially Toxic Elements on Soil Biological and Chemical Properties",slug:"the-influence-of-potentially-toxic-elements-on-soil-biological-and-chemical-properties",totalDownloads:1265,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"Soil has been a source of wealth for humans for infinite years and it continues so at present. Both mineral and organic amendments have been applied to soil to slow down its progressive impoverishment. Biological activity, mainly microbial activity, plays a key role in the stability and fertility as well as in biogeochemical cycles. Effect of potentially toxic elements on soil microbial activity, the composition of soil microbial community, soil enzyme activities, and soil physiochemical properties have been reviewed in this work.",book:{id:"8123",slug:"metals-in-soil-contamination-and-remediation",title:"Metals in Soil",fullTitle:"Metals in Soil - Contamination and Remediation"},signatures:"Om Prakash Bansal",authors:[{id:"176180",title:"Dr.",name:"Om",middleName:null,surname:"Bansal",slug:"om-bansal",fullName:"Om Bansal"}]},{id:"64810",doi:"10.5772/intechopen.82551",title:"Introductory Chapter: Relevance of Soil pH to Agriculture",slug:"introductory-chapter-relevance-of-soil-ph-to-agriculture",totalDownloads:1927,totalCrossrefCites:4,totalDimensionsCites:8,abstract:null,book:{id:"6076",slug:"soil-ph-for-nutrient-availability-and-crop-performance",title:"Soil pH for Nutrient Availability and Crop Performance",fullTitle:"Soil pH for Nutrient Availability and Crop Performance"},signatures:"Suarau Odutola Oshunsanya",authors:[{id:"175778",title:"Dr.",name:"Suarau",middleName:null,surname:"Oshunsanya",slug:"suarau-oshunsanya",fullName:"Suarau Oshunsanya"}]},{id:"72968",doi:"10.5772/intechopen.93412",title:"Heavy Metal Contamination",slug:"heavy-metal-contamination",totalDownloads:394,totalCrossrefCites:1,totalDimensionsCites:5,abstract:"In the era of industrialization, pollution has totally deteriorated the quality and diversity of life. Heavy metal contaminations are the major causes of environment deteriorations. The basic reasons are natural as well as anthropogenic. Chief sources of heavy metal contamination are air pollution, river sediments, sewage sludge, town waste composts, agricultural chemicals like fertilizers and pesticides, and industrial waste like factories releasing chemicals, anthropogenic activities, etc. Agricultural soils in many parts of the world are generally contaminated by heavy metal toxicity such as Cd, Cu, Zn, Ni, Co, Pb, Hg, As, etc. These are due to the long-term use of phosphate fertilizers, sewage sludge, dust from smelters, industrial waste, etc. Heavy metals in soils are detected with some specific instruments like atomic absorption spectroscopy, inductively coupled plasma, inductively coupled plasma-mass spectroscopy, and X-ray fluorescence and spectroscopy. Among all these instruments, atomic absorption spectroscopy (AAS) is the best because it gives the precise quantitative determination. AAS is a method applied for measuring the quantity of the trace elements present in the soil or any other samples.",book:{id:"9843",slug:"soil-contamination-threats-and-sustainable-solutions",title:"Soil Contamination",fullTitle:"Soil Contamination - Threats and Sustainable Solutions"},signatures:"Soni Kumari and Amarnath Mishra",authors:[{id:"259941",title:"Dr.",name:"Amarnath",middleName:null,surname:"Mishra",slug:"amarnath-mishra",fullName:"Amarnath Mishra"},{id:"327070",title:"MSc.",name:"Soni",middleName:null,surname:"Kumari",slug:"soni-kumari",fullName:"Soni Kumari"}]},{id:"73767",doi:"10.5772/intechopen.94307",title:"Toxicity of Cadmium in Soil-Plant-Human Continuum and Its Bioremediation Techniques",slug:"toxicity-of-cadmium-in-soil-plant-human-continuum-and-its-bioremediation-techniques",totalDownloads:471,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"Cadmium (Cd) toxicity is highly detrimental for the human and largely originated from faulty industrial and agricultural practices. Cadmium toxicity can be observed in minute concentration and highly mobile in the soil–plant system and availability in soil is mainly governed by various physio-chemical properties of the soil. Cereals and vegetables cultivated in peri-urban areas, former mining and industrial areas accumulate Cd in toxic limit as they receive Cd from multiple ways. In general, when the total cadmium (Cd) concentration in soil exceeds 8 mg kg−1, or the bioavailable Cd concentration becomes >0.001 mg kg−1, or the Cd concentration in plant tissue reaches 3–30 mg kg−1 most plants exhibit visible Cd toxicity symptoms. The impacts of Cd toxicity are seed germination, growth, photosynthesis, stomata conductance, enzyme activities and alteration in mineral nutrition. The major source of Cd in human is food chain cycle and causes disorders like “itai-itai” disease, cancer, and nephrotoxicity. Cadmium harms kidney, liver, bone and reproductive body parts and may be fatal in serious condition. WHO recommended the tolerable monthly Cd intake are 25 μg kg−1 body weights and in drinking water Cd concentration should not exceed 3 μg L−1. It is hard to remove these potent and hazardous metals from the environment as they have long mean residence time but, can be converted into less toxic form through bioremediation. This chapter focuses on the effect of Cd toxicity in soil–plant-human continuum and its bioremediation techniques to mitigate the Cd- toxicity.",book:{id:"9843",slug:"soil-contamination-threats-and-sustainable-solutions",title:"Soil Contamination",fullTitle:"Soil Contamination - Threats and Sustainable Solutions"},signatures:"Asik Dutta, Abhik Patra, Hanuman Singh Jatav, Surendra Singh Jatav, Satish Kumar Singh, Eetela Sathyanarayana, Sudhanshu Verma and Pavan Singh",authors:[{id:"303932",title:"Dr.",name:"Sudhanshu",middleName:null,surname:"Verma",slug:"sudhanshu-verma",fullName:"Sudhanshu Verma"},{id:"317244",title:"Dr.",name:"Hanuman",middleName:"Singh",surname:"Jatav",slug:"hanuman-jatav",fullName:"Hanuman Jatav"},{id:"324053",title:"Dr.",name:"Surendra",middleName:"Singh",surname:"Jatav",slug:"surendra-jatav",fullName:"Surendra Jatav"},{id:"324054",title:"Dr.",name:"Satish",middleName:null,surname:"Singh",slug:"satish-singh",fullName:"Satish Singh"},{id:"333492",title:"Dr.",name:"Asik",middleName:null,surname:"Dutta",slug:"asik-dutta",fullName:"Asik Dutta"},{id:"333493",title:"Ph.D. Student",name:"Abhik",middleName:null,surname:"Patra",slug:"abhik-patra",fullName:"Abhik Patra"},{id:"333494",title:"Mr.",name:"Pavan",middleName:null,surname:"Singh",slug:"pavan-singh",fullName:"Pavan Singh"},{id:"333495",title:"Dr.",name:"Eetela",middleName:null,surname:"Sathyanarayana",slug:"eetela-sathyanarayana",fullName:"Eetela Sathyanarayana"}]}],mostDownloadedChaptersLast30Days:[{id:"64810",title:"Introductory Chapter: Relevance of Soil pH to Agriculture",slug:"introductory-chapter-relevance-of-soil-ph-to-agriculture",totalDownloads:1931,totalCrossrefCites:4,totalDimensionsCites:8,abstract:null,book:{id:"6076",slug:"soil-ph-for-nutrient-availability-and-crop-performance",title:"Soil pH for Nutrient Availability and Crop Performance",fullTitle:"Soil pH for Nutrient Availability and Crop Performance"},signatures:"Suarau Odutola Oshunsanya",authors:[{id:"175778",title:"Dr.",name:"Suarau",middleName:null,surname:"Oshunsanya",slug:"suarau-oshunsanya",fullName:"Suarau Oshunsanya"}]},{id:"64054",title:"Metal-Contaminated Soil Remediation: Phytoremediation, Chemical Leaching and Electrochemical Remediation",slug:"metal-contaminated-soil-remediation-phytoremediation-chemical-leaching-and-electrochemical-remediati",totalDownloads:1907,totalCrossrefCites:4,totalDimensionsCites:15,abstract:"Soil contamination has led to serious land tenure problems, reduction in land usability for agricultural production; as a consequence, food insecurity is nowadays a global challenge. Indeed, with rapid population growth across the world, the food demand for consumption has drastically increased and traditional ways of producing food cannot meet with the actual demand. Industrialization has been acknowledged as a way out to sustain humanity with food. Unfortunately, the later has further turn into a threat to the environment. In effect, several potentially toxic elements (PTE) are being released in the environment and soil systems; and arable or agricultural lands are getting restraint, limited and scarce. Nowadays, there is a consensus on remediating contaminated lands with PTE, mainly inorganic contaminants, metals. The state at which a metal is found in the soil greatly influences its bioavailability, interaction with plants and the level at which it will threaten (toxicity) the environment and thus human. It even defines the remediation approaches to be applied for the soil restoration. This chapter will provide an insight on the occurrence of PTE in the soil, bioavailability and remediation approaches namely phytoremediation, chemical leaching and electrochemical remediation; and finally highlight the future research direction on this topic.",book:{id:"8123",slug:"metals-in-soil-contamination-and-remediation",title:"Metals in Soil",fullTitle:"Metals in Soil - Contamination and Remediation"},signatures:"Binessi Edouard Ifon, Alexis Crépin Finagnon Togbé,\nLyde Arsène Sewedo Tometin, Fidèle Suanon and Arouna Yessoufou",authors:[{id:"257187",title:"Dr.",name:"Fidèle",middleName:null,surname:"Suanon",slug:"fidele-suanon",fullName:"Fidèle Suanon"},{id:"263966",title:"MSc.",name:"Binessi Edouard",middleName:null,surname:"Ifon",slug:"binessi-edouard-ifon",fullName:"Binessi Edouard Ifon"},{id:"263968",title:"Dr.",name:"Arouan",middleName:null,surname:"Yessoufou",slug:"arouan-yessoufou",fullName:"Arouan Yessoufou"},{id:"267945",title:"Dr.",name:"Alexis Finagnon Crepin",middleName:null,surname:"Togbe",slug:"alexis-finagnon-crepin-togbe",fullName:"Alexis Finagnon Crepin Togbe"},{id:"267946",title:"Dr.",name:"Lyde A.S.",middleName:null,surname:"Tomètin",slug:"lyde-a.s.-tometin",fullName:"Lyde A.S. Tomètin"}]},{id:"76810",title:"Chemical Characteristics of Humic Substances in Nature",slug:"chemical-characteristics-of-humic-substances-in-nature",totalDownloads:337,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Humic substances are the main constituents of natural organic matter, found in both aquatic and terrestrial environments. Humic substances are a complex, dispersed, and heterogeneous mixture of various organic compounds synthesized from organic matter residues, decomposed by microorganisms. Most scientists indicate that humic substances are as a supramolecular association of small heterogeneous molecules stabilized by weak intermolecular bonds. When these substances are presented in water intended for drinking or industrial use, it can have a significant impact on the treatability of this water and on the success of chemical disinfection processes, due to possible formation of organic compounds harmful to human health. Moreover, the humic substances can be used of several ways such as fertilizer to help in the development of plants, to improve soil erosion and to removal of organic compounds and metals from soils and waters. In addition, humic substances suggest an important role in mitigating areas degraded by the phytoremediation technique. The purpose of chapter is to provide an overview of humic substances and to discuss their concepts, chemical characteristics, ecological effects and technological applications for soils and aquatic systems.",book:{id:"10590",slug:"humic-substances",title:"Humic Substances",fullTitle:"Humic Substances"},signatures:"Claudio Fernando Mahler, Nicoly Dal Santo Svierzoski and Cassiano Augusto Rolim Bernardino",authors:[{id:"278699",title:"Dr.",name:"Claudio Fernando",middleName:null,surname:"Mahler",slug:"claudio-fernando-mahler",fullName:"Claudio Fernando Mahler"},{id:"417399",title:"Dr.",name:"Nicoly Dal Santo",middleName:null,surname:"Svierzoski",slug:"nicoly-dal-santo-svierzoski",fullName:"Nicoly Dal Santo Svierzoski"},{id:"417400",title:"Dr.",name:"Cassiano Augusto Rolim",middleName:null,surname:"Bernardino",slug:"cassiano-augusto-rolim-bernardino",fullName:"Cassiano Augusto Rolim Bernardino"}]},{id:"65024",title:"Influence of Chemical Properties of Soil on the Corrosion Morphology of Carbon Steel Pipes",slug:"influence-of-chemical-properties-of-soil-on-the-corrosion-morphology-of-carbon-steel-pipes",totalDownloads:1502,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Corrosive soils are responsible for the deterioration of buried underground utilities such as buried steel pipes. Frequent pipe failures are reported due to corrosive soil globally. Although soil’s corrosion phenomenon has been understood and identified long time ago, pipe failures due to corrosive soil are uncontrollable and unavoidable despite the use of protective coatings and techniques such as cathodic protection. Therefore, it is essential to review the causes of soil’s corrosivity for the protection of steel pipes. This chapter demonstrates the influence of varying moisture and chloride contents of soils on the corrosion of coated and uncoated steel pipes. Carbon steel specimens (coated and uncoated) were buried in soils of 20, 40, 60, and 80 wt.% moisture content, respectively, while the chloride concentration introduced in soil was 0, 5, and 10 wt.%, respectively. Through the analysis of experiments, it is revealed that the corrosion rate of pipes buried in soil increases with increase in moisture content up to critical moisture and chloride values. The influence of soil’s moisture and chloride on the corrosion products formed on steel pipes was investigated and comprehensively explained in this chapter. Authors believe that the knowledge presented in this chapter can be applied to other structures or utilities buried in corrosive soils.",book:{id:"8123",slug:"metals-in-soil-contamination-and-remediation",title:"Metals in Soil",fullTitle:"Metals in Soil - Contamination and Remediation"},signatures:"Muhammad Wasim and Shahrukh Shoaib",authors:[{id:"257667",title:"Dr.",name:"Muhammad",middleName:null,surname:"Wasim",slug:"muhammad-wasim",fullName:"Muhammad Wasim"},{id:"271218",title:"Mr.",name:"Shahrukh",middleName:null,surname:"Shoaib",slug:"shahrukh-shoaib",fullName:"Shahrukh Shoaib"}]},{id:"74460",title:"Excessive and Disproportionate Use of Chemicals Cause Soil Contamination and Nutritional Stress",slug:"excessive-and-disproportionate-use-of-chemicals-cause-soil-contamination-and-nutritional-stress",totalDownloads:567,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Incredible achievements have been made in agricultural production worldwide, but many daunting challenges remain unresolved to ensure food security and environmental sustainability. Chemical fertilisers are used in excessive and disproportionate quantities to raise crop yields in order to combat certain circumstances. However, apart from being processed in crop plants, chemical fertilisers above the threshold level pollute the atmosphere. As the availability of nutrients becomes a constraint of plant growth and production, sustained crop productivity relies on constant renewal. To increase agriculture production and maintain soil fertility, the application of chemical fertilisers is indispensable. However, insufficient or unnecessary application of fertiliser does not guarantee consistently growing yields, which can result in low efficiency of nutrient usage. Today, the key goals are the study of the effective use of chemicals, the reduction of production costs and the efficient use of fertilisation.",book:{id:"9843",slug:"soil-contamination-threats-and-sustainable-solutions",title:"Soil Contamination",fullTitle:"Soil Contamination - Threats and Sustainable Solutions"},signatures:"Nikita Bisht and Puneet Singh Chauhan",authors:[{id:"322545",title:"Ph.D. Student",name:"Nikita",middleName:null,surname:"Bisht",slug:"nikita-bisht",fullName:"Nikita Bisht"},{id:"322843",title:"Dr.",name:"Puneet Singh",middleName:null,surname:"Chauhan",slug:"puneet-singh-chauhan",fullName:"Puneet Singh Chauhan"}]}],onlineFirstChaptersFilter:{topicId:"675",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"May 14th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:7,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"306970",title:"Mr.",name:"Amin",middleName:null,surname:"Tamadon",slug:"amin-tamadon",fullName:"Amin Tamadon",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002oHR5wQAG/Profile_Picture_1623910304139",institutionString:null,institution:{name:"Bushehr University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",institutionString:null,institution:{name:"Miguel Hernandez University",institutionURL:null,country:{name:"Spain"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",institutionString:null,institution:{name:"Alexandria University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. Neiva",profilePictureURL:"https://mts.intechopen.com/storage/users/213786/images/system/213786.png",institutionString:null,institution:{name:"University of Beira Interior",institutionURL:null,country:{name:"Portugal"}}},{id:"39275",title:"Prof.",name:"Herbert Ryan",middleName:null,surname:"Marini",slug:"herbert-ryan-marini",fullName:"Herbert Ryan Marini",profilePictureURL:"https://mts.intechopen.com/storage/users/39275/images/9459_n.jpg",institutionString:null,institution:{name:"University of Messina",institutionURL:null,country:{name:"Italy"}}},{id:"196218",title:"Dr.",name:"Pasquale",middleName:null,surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci",profilePictureURL:"https://mts.intechopen.com/storage/users/196218/images/system/196218.png",institutionString:null,institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}]},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031RJmlQAG/Profile_Picture_1600760167494",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung in Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture in college. Dr. Chen's research interests are bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published over 60 research papers, reviewed over 260 manuscripts, and edited at least 150 papers in international peer-review journals.",institutionString:null,institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano",profilePictureURL:"https://mts.intechopen.com/storage/users/313856/images/system/313856.png",institutionString:"University of Orléans",institution:{name:"University of Orléans",institutionURL:null,country:{name:"France"}}},{id:"33993",title:"Dr.",name:"Jose Carlos",middleName:null,surname:"Jimenez-Lopez",slug:"jose-carlos-jimenez-lopez",fullName:"Jose Carlos Jimenez-Lopez",profilePictureURL:"https://mts.intechopen.com/storage/users/33993/images/system/33993.jpg",institutionString:null,institution:{name:"Spanish National Research Council",institutionURL:null,country:{name:"Spain"}}},{id:"191770",title:"Dr.",name:"Mohamed A.",middleName:null,surname:"El-Esawi",slug:"mohamed-a.-el-esawi",fullName:"Mohamed A. El-Esawi",profilePictureURL:"https://mts.intechopen.com/storage/users/191770/images/system/191770.jpeg",institutionString:null,institution:{name:"Tanta University",institutionURL:null,country:{name:"Egypt"}}},{id:"247858",title:"Dr.",name:"Saddam",middleName:null,surname:"Hussain",slug:"saddam-hussain",fullName:"Saddam Hussain",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSF2aQAG/Profile_Picture_1625658281836",institutionString:null,institution:{name:"University of Agriculture Faisalabad",institutionURL:null,country:{name:"Pakistan"}}}]}]},overviewPageOFChapters:{paginationCount:43,paginationItems:[{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. Drury",slug:"new-and-emerging-technologies-for-integrative-ambulatory-autonomic-assessment-and-intervention-as-a-",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}}]},overviewPagePublishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"7264",title:"Calcium and Signal Transduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7264.jpg",slug:"calcium-and-signal-transduction",publishedDate:"October 24th 2018",editedByType:"Edited by",bookSignature:"John N. Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",biography:"Full Professor and Vice Chair, Division of Pharmacology, Loma Linda University, School of Medicine. He received his B.S. Degree in Biology at La Sierra University, Riverside California (1980) and a PhD in Pharmacology from Loma Linda University School of Medicine (1988). Post-Doctoral Fellow at University of California, Irvine, College of Medicine 1989-1992 with a focus on autonomic nerve function in blood vessels and the impact of aging on the function of these nerves and overall blood vessel function. Twenty years of research funding and served on NIH R01 review panels, Editor-In-Chief of Edorium Journal of Aging Research. Serves as a peer reviewer for biomedical journals. Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}]},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",institutionURL:null,country:{name:"Hungary"}}}]},{type:"book",id:"8008",title:"Antioxidants",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8008.jpg",slug:"antioxidants",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Emad Shalaby",hash:"76361b4061e830906267933c1c670027",volumeInSeries:5,fullTitle:"Antioxidants",editors:[{id:"63600",title:"Prof.",name:"Emad",middleName:null,surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby",profilePictureURL:"https://mts.intechopen.com/storage/users/63600/images/system/63600.png",biography:"Dr. Emad Shalaby is a professor of biochemistry on the Biochemistry Department Faculty of Agriculture, Cairo University. He\nreceived a short-term scholarship to carry out his post-doctoral\nstudies abroad, from Japan International Cooperation Agency\n(JICA), in coordination with the Egyptian government. Dr.\nShalaby speaks fluent English and his native Arabic. He has 77\ninternationally published research papers, has attended 15 international conferences, and has contributed to 18 international books and chapters.\nDr. Shalaby works as a reviewer on over one hundred international journals and is\non the editorial board of more than twenty-five international journals. He is a member of seven international specialized scientific societies, besides his local one, and\nhe has won seven prizes.",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}]}]},openForSubmissionBooks:{paginationCount:4,paginationItems:[{id:"11445",title:"Multi-Agent Technologies and Machine Learning",coverURL:"https://cdn.intechopen.com/books/images_new/11445.jpg",hash:"d980826615baa6e33456e2a79064c5e8",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"March 29th 2022",isOpenForSubmission:!0,editors:[{id:"265237",title:"Prof.",name:"Igor",surname:"Sheremet",slug:"igor-sheremet",fullName:"Igor Sheremet"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11446",title:"Industry 4.0 - Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11446.jpg",hash:"be984f45b90c1003798661ef885d8a34",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 12th 2022",isOpenForSubmission:!0,editors:[{id:"303193",title:"Dr.",name:"Meisam",surname:"Gordan",slug:"meisam-gordan",fullName:"Meisam Gordan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11448",title:"Artificial Neural Networks - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11448.jpg",hash:"e57ff97a39cfc6fe68a1ac62b503dbe9",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 3rd 2022",isOpenForSubmission:!0,editors:[{id:"22866",title:"Dr.",name:"Chi Leung Patrick",surname:"Hui",slug:"chi-leung-patrick-hui",fullName:"Chi Leung Patrick Hui"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11447",title:"Swarm Intelligence - Recent Advances and Current Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11447.jpg",hash:"f68e3c3430a74fc7a7eb97f6ea2bb42e",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 14th 2022",isOpenForSubmission:!0,editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:17,paginationItems:[{id:"81751",title:"NanoBioSensors: From Electrochemical Sensors Improvement to Theranostic Applications",doi:"10.5772/intechopen.102552",signatures:"Anielle C.A. Silva, Eliete A. Alvin, Lais S. de Jesus, Caio C.L. de França, Marílya P.G. da Silva, Samaysa L. Lins, Diógenes Meneses, Marcela R. Lemes, Rhanoica O. Guerra, Marcos V. da Silva, Carlo J.F. de Oliveira, Virmondes Rodrigues Junior, Renata M. Etchebehere, Fabiane C. de Abreu, Bruno G. Lucca, Sanívia A.L. Pereira, Rodrigo C. Rosa and Noelio O. Dantas",slug:"nanobiosensors-from-electrochemical-sensors-improvement-to-theranostic-applications",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81766",title:"Evolution of Organoids in Oncology",doi:"10.5772/intechopen.104251",signatures:"Allen Thayakumar Basanthakumar, Janitha Chandrasekhar Darlybai and Jyothsna Ganesh",slug:"evolution-of-organoids-in-oncology",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81678",title:"Developmental Studies on Practical Enzymatic Phosphate Ion Biosensors and Microbial BOD Biosensors, and New Insights into the Future Perspectives of These Biosensor Fields",doi:"10.5772/intechopen.104377",signatures:"Hideaki Nakamura",slug:"developmental-studies-on-practical-enzymatic-phosphate-ion-biosensors-and-microbial-bod-biosensors-a",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hideaki",surname:"Nakamura"}],book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81547",title:"Organoids and Commercialization",doi:"10.5772/intechopen.104706",signatures:"Anubhab Mukherjee, Aprajita Sinha, Maheshree Maibam, Bharti Bisht and Manash K. Paul",slug:"organoids-and-commercialization",totalDownloads:28,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81412",title:"Mathematical Morphology and the Heart Signals",doi:"10.5772/intechopen.104113",signatures:"Taouli Sidi Ahmed",slug:"mathematical-morphology-and-the-heart-signals",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81360",title:"Deep Learning Algorithms for Efficient Analysis of ECG Signals to Detect Heart Disorders",doi:"10.5772/intechopen.103075",signatures:"Sumagna Dey, Rohan Pal and Saptarshi Biswas",slug:"deep-learning-algorithms-for-efficient-analysis-of-ecg-signals-to-detect-heart-disorders",totalDownloads:31,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81294",title:"Applications of Neural Organoids in Neurodevelopment and Regenerative Medicine",doi:"10.5772/intechopen.104044",signatures:"Jing Gong, Jiahui Kang, Minghui Li, Xiao Liu, Jun Yang and Haiwei Xu",slug:"applications-of-neural-organoids-in-neurodevelopment-and-regenerative-medicine",totalDownloads:25,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81318",title:"Retinal Organoids over the Decade",doi:"10.5772/intechopen.104258",signatures:"Jing Yuan and Zi-Bing Jin",slug:"retinal-organoids-over-the-decade",totalDownloads:38,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81068",title:"Characteristic Profiles of Heart Rate Variability in Depression and Anxiety",doi:"10.5772/intechopen.104205",signatures:"Toshikazu Shinba",slug:"characteristic-profiles-of-heart-rate-variability-in-depression-and-anxiety",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"80691",title:"Applications of Quantum Mechanics, Laws of Classical Physics, and Differential Calculus to Evaluate Source Localization According to the Electroencephalogram",doi:"10.5772/intechopen.102831",signatures:"Kristin S. Williams",slug:"applications-of-quantum-mechanics-laws-of-classical-physics-and-differential-calculus-to-evaluate-so",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}}]},subseriesFiltersForOFChapters:[{caption:"Bioinformatics and Medical Informatics",value:7,count:13,group:"subseries"}],publishedBooks:{paginationCount:8,paginationItems:[{type:"book",id:"10859",title:"Data Mining",subtitle:"Concepts and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10859.jpg",slug:"data-mining-concepts-and-applications",publishedDate:"March 30th 2022",editedByType:"Edited by",bookSignature:"Ciza Thomas",hash:"63a4e514e537d3962cf53ef1c6b9d5eb",volumeInSeries:8,fullTitle:"Data Mining - Concepts and Applications",editors:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",slug:"ciza-thomas",fullName:"Ciza Thomas",profilePictureURL:"https://mts.intechopen.com/storage/users/43680/images/system/43680.jpeg",institutionString:null,institution:{name:"Government of Kerala",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10651",title:"Machine Learning",subtitle:"Algorithms, Models and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10651.jpg",slug:"machine-learning-algorithms-models-and-applications",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Jaydip Sen",hash:"6208156401c496e0a4ca5ff4265324cc",volumeInSeries:7,fullTitle:"Machine Learning - Algorithms, Models and Applications",editors:[{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",institutionString:"Praxis Business School",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9869",title:"Self-Driving Vehicles and Enabling Technologies",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9869.jpg",slug:"self-driving-vehicles-and-enabling-technologies",publishedDate:"September 22nd 2021",editedByType:"Edited by",bookSignature:"Marian Găiceanu",hash:"fd451ca2e4785ef098e04b7d695a18d9",volumeInSeries:6,fullTitle:"Self-Driving Vehicles and Enabling Technologies",editors:[{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',institutionURL:null,country:{name:"Romania"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9958",title:"Artificial Intelligence",subtitle:"Latest Advances, New Paradigms and Novel Applications",coverURL:"https://cdn.intechopen.com/books/images_new/9958.jpg",slug:"artificial-intelligence-latest-advances-new-paradigms-and-novel-applications",publishedDate:"September 1st 2021",editedByType:"Edited by",bookSignature:"Eneko Osaba, Esther Villar, Jesús L. Lobo and Ibai Laña",hash:"39648fbfdaa11385097d62b1f13aad54",volumeInSeries:5,fullTitle:"Artificial Intelligence - Latest Advances, New Paradigms and Novel Applications",editors:[{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9963",title:"Advances and Applications in Deep Learning",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9963.jpg",slug:"advances-and-applications-in-deep-learning",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"0d51ba46f22e55cb89140f60d86a071e",volumeInSeries:4,fullTitle:"Advances and Applications in Deep Learning",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7656",title:"Fuzzy Logic",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7656.jpg",slug:"fuzzy-logic",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Constantin Volosencu",hash:"54f092d4ffe0abf5e4172a80025019bc",volumeInSeries:3,fullTitle:"Fuzzy Logic",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",institutionURL:null,country:{name:"Romania"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - Recent Advances, New Perspectives and Applications",editors:[{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",institutionString:"Tecnalia Research & Innovation",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7723",title:"Artificial Intelligence",subtitle:"Applications in Medicine and Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7723.jpg",slug:"artificial-intelligence-applications-in-medicine-and-biology",publishedDate:"July 31st 2019",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"a3852659e727f95c98c740ed98146011",volumeInSeries:1,fullTitle:"Artificial Intelligence - Applications in Medicine and Biology",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Evolutionary Computation",value:25,count:1},{group:"subseries",caption:"Machine Learning and Data Mining",value:26,count:3},{group:"subseries",caption:"Applied Intelligence",value:22,count:4}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1},{group:"publicationYear",caption:"2021",value:2021,count:3},{group:"publicationYear",caption:"2020",value:2020,count:2},{group:"publicationYear",caption:"2019",value:2019,count:2}],authors:{paginationCount:302,paginationItems:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, Mexico. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424836",title:"Dr.",name:"Orsolya",middleName:null,surname:"Borsai",slug:"orsolya-borsai",fullName:"Orsolya Borsai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",country:{name:"Romania"}}},{id:"422262",title:"Ph.D.",name:"Paola Andrea",middleName:null,surname:"Palmeros-Suárez",slug:"paola-andrea-palmeros-suarez",fullName:"Paola Andrea Palmeros-Suárez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Guadalajara",country:{name:"Mexico"}}}]}},subseries:{item:{id:"8",type:"subseries",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11404,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",slug:"hitoshi-tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",slug:"marcus-vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},onlineFirstChapters:{paginationCount:0,paginationItems:[]},publishedBooks:{paginationCount:6,paginationItems:[{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",publishedDate:"March 23rd 2022",editedByType:"Edited by",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",hash:"8b43add5389ba85743e0a9491e4b9943",volumeInSeries:27,fullTitle:"Vitamin K - Recent Topics on the Biology and Chemistry",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7004",title:"Metabolomics",subtitle:"New Insights into Biology and Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/7004.jpg",slug:"metabolomics-new-insights-into-biology-and-medicine",publishedDate:"July 1st 2020",editedByType:"Edited by",bookSignature:"Wael N. Hozzein",hash:"35a30d8241442b716a4aab830b6de28f",volumeInSeries:16,fullTitle:"Metabolomics - New Insights into Biology and Medicine",editors:[{id:"189233",title:"Prof.",name:"Wael N.",middleName:"Nabil",surname:"Hozzein",slug:"wael-n.-hozzein",fullName:"Wael N. Hozzein",profilePictureURL:"https://mts.intechopen.com/storage/users/189233/images/system/189233.jpeg",institutionString:"Beni-Suef University",institution:{name:"Beni-Suef University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6967",title:"Prebiotics and Probiotics",subtitle:"Potential Benefits in Nutrition and Health",coverURL:"https://cdn.intechopen.com/books/images_new/6967.jpg",slug:"prebiotics-and-probiotics-potential-benefits-in-nutrition-and-health",publishedDate:"March 4th 2020",editedByType:"Edited by",bookSignature:"Elena Franco-Robles and Joel Ramírez-Emiliano",hash:"11781d6b1c070edcf204518e632033be",volumeInSeries:8,fullTitle:"Prebiotics and Probiotics - Potential Benefits in Nutrition and Health",editors:[{id:"219102",title:"Dr.",name:"Elena",middleName:null,surname:"Franco-Robles",slug:"elena-franco-robles",fullName:"Elena Franco-Robles",profilePictureURL:"https://mts.intechopen.com/storage/users/219102/images/system/219102.jpg",institutionString:"Universidad de Guanajuato",institution:{name:"Universidad de Guanajuato",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8292",title:"Oral Health by Using Probiotic Products",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8292.jpg",slug:"oral-health-by-using-probiotic-products",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Razzagh Mahmoudi",hash:"327e750e83634800ace02fe62607c21e",volumeInSeries:5,fullTitle:"Oral Health by Using Probiotic Products",editors:[{id:"245925",title:"Dr.",name:"Razzagh",middleName:null,surname:"Mahmoudi",slug:"razzagh-mahmoudi",fullName:"Razzagh Mahmoudi",profilePictureURL:"https://mts.intechopen.com/storage/users/245925/images/system/245925.jpg",institutionString:"Qazvin University of Medical Sciences",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.jpg",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"4",title:"Fungal Infectious Diseases",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/108278",hash:"",query:{},params:{id:"108278"},fullPath:"/profiles/108278",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()