The eighth edition of TNM for lung cancer.
\\n\\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\\n\\n\\n\\n\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"4504",leadTitle:null,fullTitle:"Ionic Liquids - Current State of the Art",title:"Ionic Liquids",subtitle:"Current State of the Art",reviewType:"peer-reviewed",abstract:"Ionic liquids continue to attract a great deal of research attention in an even increasing number of areas, including more traditional areas such as synthesis (organic and materials) and physical properties studies and predictions, as well as less obvious areas such as lubrication and enzymatic transformations. In this volume, recent advances in a number of these different areas are reported and reviewed, thus granting some appreciation for the future that ionic liquids research holds, and affording inspiration for those who have not previously considered the application of ionic liquids in their area of interest.",isbn:null,printIsbn:"978-953-51-2122-0",pdfIsbn:"978-953-51-4223-2",doi:"10.5772/58515",price:159,priceEur:175,priceUsd:205,slug:"ionic-liquids-current-state-of-the-art",numberOfPages:692,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"da08fe684d11113d583db336e16ee5b6",bookSignature:"Scott Handy",publishedDate:"May 21st 2015",coverURL:"https://cdn.intechopen.com/books/images_new/4504.jpg",numberOfDownloads:43872,numberOfWosCitations:126,numberOfCrossrefCitations:50,numberOfCrossrefCitationsByBook:7,numberOfDimensionsCitations:112,numberOfDimensionsCitationsByBook:11,hasAltmetrics:0,numberOfTotalCitations:288,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 28th 2014",dateEndSecondStepPublish:"May 26th 2014",dateEndThirdStepPublish:"August 23rd 2014",dateEndFourthStepPublish:"November 21st 2014",dateEndFifthStepPublish:"December 21st 2014",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"42658",title:"Prof.",name:"Scott",middleName:null,surname:"Handy",slug:"scott-handy",fullName:"Scott Handy",profilePictureURL:"https://mts.intechopen.com/storage/users/42658/images/system/42658.jpg",biography:"Dr. Scott Handy received his Ph.D. in Chemistry from Indiana University in 1996 under the direction of Professor Paul Grieco. Following an NIH postdoctoral fellowship at Stanford University in the labs of Professor Paul Wender, he joined the Chemistry Department at Binghamton University in 1999. In 2006 he moved to Middle Tennessee State University as an Associate Professor and was promoted to Professor in 2011. His research interests are in the areas of cross-coupling reactions (particularly regioselectivity in the couplings of polyhaloheteroaromatics), ionic liquids (as recyclable solvents for transition metal-catalyzed reactions and electrochemistry), and the synthesis and use of aurones to address biological questions.",institutionString:"Middle Tennessee State University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Middle Tennessee State University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"935",title:"Fluid Dynamics",slug:"materials-science-fluid-mechanics-fluid-dynamics"}],chapters:[{id:"48451",title:"“Green” Pericyclic Reactions Assisted by Ionic Liquids",doi:"10.5772/59179",slug:"-green-pericyclic-reactions-assisted-by-ionic-liquids",totalDownloads:1752,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Rafael Martínez-Palou, Octavio Olivares-Xometl, Natalya V.\nLikhanova and Irina Lijanova",downloadPdfUrl:"/chapter/pdf-download/48451",previewPdfUrl:"/chapter/pdf-preview/48451",authors:[{id:"18064",title:"Dr.",name:"Rafael",surname:"Martínez Palou",slug:"rafael-martinez-palou",fullName:"Rafael Martínez Palou"},{id:"171459",title:"Dr.",name:"Octavio",surname:"Olivares-Xometl",slug:"octavio-olivares-xometl",fullName:"Octavio Olivares-Xometl"}],corrections:null},{id:"48463",title:"Heck Coupling in Ionic Liquids",doi:"10.5772/59089",slug:"heck-coupling-in-ionic-liquids",totalDownloads:1791,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Ahmed Al Otaibi, Christopher P. Gordon and Adam McCluskey",downloadPdfUrl:"/chapter/pdf-download/48463",previewPdfUrl:"/chapter/pdf-preview/48463",authors:[{id:"44482",title:"Prof.",name:"Adam",surname:"McCluskey",slug:"adam-mccluskey",fullName:"Adam McCluskey"}],corrections:null},{id:"48464",title:"Deep Eutectic Solvents in Organic Synthesis",doi:"10.5772/59254",slug:"deep-eutectic-solvents-in-organic-synthesis",totalDownloads:2751,totalCrossrefCites:7,totalDimensionsCites:13,hasAltmetrics:0,abstract:null,signatures:"Scott Handy",downloadPdfUrl:"/chapter/pdf-download/48464",previewPdfUrl:"/chapter/pdf-preview/48464",authors:[{id:"42658",title:"Prof.",name:"Scott",surname:"Handy",slug:"scott-handy",fullName:"Scott Handy"}],corrections:null},{id:"48458",title:"Applications of Ionic Liquids (ILs) in Synthesis of Inorganic Nanomaterials",doi:"10.5772/59048",slug:"applications-of-ionic-liquids-ils-in-synthesis-of-inorganic-nanomaterials",totalDownloads:1683,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Wenjun Zheng, Di Li and Wei Guo",downloadPdfUrl:"/chapter/pdf-download/48458",previewPdfUrl:"/chapter/pdf-preview/48458",authors:[{id:"171527",title:"Prof.",name:"Wenjun",surname:"Zheng",slug:"wenjun-zheng",fullName:"Wenjun Zheng"},{id:"171554",title:"Dr.",name:"Di",surname:"Li",slug:"di-li",fullName:"Di Li"},{id:"173214",title:"Dr.",name:"Wei",surname:"Guo",slug:"wei-guo",fullName:"Wei Guo"}],corrections:null},{id:"48460",title:"Ionic Liquid-Mediated Activation of Lipase-Catalysed Reaction",doi:"10.5772/59243",slug:"ionic-liquid-mediated-activation-of-lipase-catalysed-reaction",totalDownloads:1356,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Toshiyuki Itoh",downloadPdfUrl:"/chapter/pdf-download/48460",previewPdfUrl:"/chapter/pdf-preview/48460",authors:[{id:"171597",title:"Prof.",name:"Toshiyuki",surname:"Itoh",slug:"toshiyuki-itoh",fullName:"Toshiyuki Itoh"}],corrections:null},{id:"48461",title:"Solvent Dependence of Enzymatic Enantioselectivity in Ionic Liquids",doi:"10.5772/58998",slug:"solvent-dependence-of-enzymatic-enantioselectivity-in-ionic-liquids",totalDownloads:1175,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Hidetaka Noritomi",downloadPdfUrl:"/chapter/pdf-download/48461",previewPdfUrl:"/chapter/pdf-preview/48461",authors:[{id:"18170",title:"Dr.",name:"Hidetaka",surname:"Noritomi",slug:"hidetaka-noritomi",fullName:"Hidetaka Noritomi"}],corrections:null},{id:"48466",title:"Structural and Physical Aspects of Ionic Liquid Aggregates in Solution",doi:"10.5772/59287",slug:"structural-and-physical-aspects-of-ionic-liquid-aggregates-in-solution",totalDownloads:1924,totalCrossrefCites:4,totalDimensionsCites:11,hasAltmetrics:0,abstract:null,signatures:"Clarissa P. Frizzo, Aniele Z. Tier, Caroline R. Bender, Izabelle M.\nGindri, Marcos A. Villetti, Nilo Zanatta, Helio G. Bonacorso and\nMarcos A.P. Martins",downloadPdfUrl:"/chapter/pdf-download/48466",previewPdfUrl:"/chapter/pdf-preview/48466",authors:[{id:"23711",title:"Dr.",name:"Marcos Antonio",surname:"Pinto Martins",slug:"marcos-antonio-pinto-martins",fullName:"Marcos Antonio Pinto Martins"},{id:"153488",title:"M.Sc.",name:"Aniele",surname:"Tier",slug:"aniele-tier",fullName:"Aniele Tier"},{id:"171855",title:"Dr.",name:"Clarissa",surname:"Frizzo",slug:"clarissa-frizzo",fullName:"Clarissa Frizzo"},{id:"171856",title:"Dr.",name:"Marcos",surname:"Villetti",slug:"marcos-villetti",fullName:"Marcos Villetti"},{id:"171857",title:"Dr.",name:"Nilo",surname:"Zanatta",slug:"nilo-zanatta",fullName:"Nilo Zanatta"},{id:"171858",title:"Dr.",name:"Caroline",surname:"Bender",slug:"caroline-bender",fullName:"Caroline Bender"},{id:"171859",title:"MSc.",name:"Izabelle",surname:"Gindri",slug:"izabelle-gindri",fullName:"Izabelle Gindri"},{id:"173239",title:"Dr.",name:"Helio",surname:"Bonacorso",slug:"helio-bonacorso",fullName:"Helio Bonacorso"}],corrections:null},{id:"48455",title:"Thermal Behaviour of Pure Ionic Liquids",doi:"10.5772/59271",slug:"thermal-behaviour-of-pure-ionic-liquids",totalDownloads:2200,totalCrossrefCites:8,totalDimensionsCites:26,hasAltmetrics:0,abstract:null,signatures:"Elena Gómez, Noelia Calvar and Ángeles Domínguez",downloadPdfUrl:"/chapter/pdf-download/48455",previewPdfUrl:"/chapter/pdf-preview/48455",authors:[{id:"171493",title:"Dr.",name:"Angeles",surname:"Dominguez",slug:"angeles-dominguez",fullName:"Angeles Dominguez"},{id:"172443",title:"Dr.",name:"Noelia",surname:"Calvar",slug:"noelia-calvar",fullName:"Noelia Calvar"},{id:"172444",title:"Dr.",name:"Elena",surname:"Gómez",slug:"elena-gomez",fullName:"Elena Gómez"}],corrections:null},{id:"48470",title:"Solubility of Bioactive, Inorganic and Polymeric Solids in Ionic Liquids — Experimental and Prediction Perspectives",doi:"10.5772/60501",slug:"solubility-of-bioactive-inorganic-and-polymeric-solids-in-ionic-liquids-experimental-and-prediction-",totalDownloads:1810,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Gonçalo V.S.M. Carrera, Małgorzata E. Zakrzewska, Ana V. M. Nunes\nand Luis C. Branco",downloadPdfUrl:"/chapter/pdf-download/48470",previewPdfUrl:"/chapter/pdf-preview/48470",authors:[{id:"18681",title:"Dr.",name:"Luis C.",surname:"Branco",slug:"luis-c.-branco",fullName:"Luis C. Branco"},{id:"171914",title:"Dr.",name:"Gonçalo",surname:"Carrera",slug:"goncalo-carrera",fullName:"Gonçalo Carrera"},{id:"171915",title:"Dr.",name:"Ana",surname:"Nunes",slug:"ana-nunes",fullName:"Ana Nunes"},{id:"171916",title:"Ms.",name:"Małgorzata",surname:"Zakrzewska",slug:"malgorzata-zakrzewska",fullName:"Małgorzata Zakrzewska"}],corrections:null},{id:"48447",title:"Various Self-Assembly Behaviors of Amphiphilic Molecules in Ionic Liquids",doi:"10.5772/59095",slug:"various-self-assembly-behaviors-of-amphiphilic-molecules-in-ionic-liquids",totalDownloads:1680,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Bin Dong and Yanan Gao",downloadPdfUrl:"/chapter/pdf-download/48447",previewPdfUrl:"/chapter/pdf-preview/48447",authors:[{id:"171387",title:"Prof.",name:"Yanan",surname:"Gao",slug:"yanan-gao",fullName:"Yanan Gao"}],corrections:null},{id:"48469",title:"Ionic Liquids as Surfactants – Applications as Demulsifiers of Petroleum Emulsions",doi:"10.5772/59094",slug:"ionic-liquids-as-surfactants-applications-as-demulsifiers-of-petroleum-emulsions",totalDownloads:2583,totalCrossrefCites:9,totalDimensionsCites:14,hasAltmetrics:0,abstract:null,signatures:"Rafael Martínez-Palou and Jorge Aburto",downloadPdfUrl:"/chapter/pdf-download/48469",previewPdfUrl:"/chapter/pdf-preview/48469",authors:[{id:"18064",title:"Dr.",name:"Rafael",surname:"Martínez Palou",slug:"rafael-martinez-palou",fullName:"Rafael Martínez Palou"},{id:"16428",title:"Dr.",name:"Jorge",surname:"Aburto",slug:"jorge-aburto",fullName:"Jorge Aburto"}],corrections:null},{id:"48444",title:"Extraction Based on Dispersive Assisted by Ionic Liquids",doi:"10.5772/60136",slug:"extraction-based-on-dispersive-assisted-by-ionic-liquids",totalDownloads:2149,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Negin Fasih Ramandi and Farzaneh Shemirani",downloadPdfUrl:"/chapter/pdf-download/48444",previewPdfUrl:"/chapter/pdf-preview/48444",authors:[{id:"18306",title:"Dr.",name:"Farzaneh",surname:"Shemirani",slug:"farzaneh-shemirani",fullName:"Farzaneh Shemirani"},{id:"171683",title:"Dr.",name:"Negin",surname:"Fasih Ramandi",slug:"negin-fasih-ramandi",fullName:"Negin Fasih Ramandi"}],corrections:null},{id:"48454",title:"Imidazolium-Based Ionic Liquids as Solvents for Analysis of Lipophilic Extractives from Biomass",doi:"10.5772/59075",slug:"imidazolium-based-ionic-liquids-as-solvents-for-analysis-of-lipophilic-extractives-from-biomass",totalDownloads:1212,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Kessy F. Kilulya, Bhekie B. Mamba and Titus A.M. Msagati",downloadPdfUrl:"/chapter/pdf-download/48454",previewPdfUrl:"/chapter/pdf-preview/48454",authors:[{id:"17215",title:"Prof.",name:"Bhekie B.",surname:"Mamba",slug:"bhekie-b.-mamba",fullName:"Bhekie B. Mamba"},{id:"171479",title:"Prof.",name:"Titus",surname:"Msagati",slug:"titus-msagati",fullName:"Titus Msagati"},{id:"171902",title:"Dr.",name:"Kessy",surname:"Kilulya",slug:"kessy-kilulya",fullName:"Kessy Kilulya"}],corrections:null},{id:"48465",title:"Dissolution and Hydrolysis of Lignocellulosic Biomass using Tailored Ionic Liquids",doi:"10.5772/59049",slug:"dissolution-and-hydrolysis-of-lignocellulosic-biomass-using-tailored-ionic-liquids",totalDownloads:1513,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Yue Dong, Jana Holm and Ulla Lassi",downloadPdfUrl:"/chapter/pdf-download/48465",previewPdfUrl:"/chapter/pdf-preview/48465",authors:[{id:"95000",title:"Prof.",name:"Ulla",surname:"Lassi",slug:"ulla-lassi",fullName:"Ulla Lassi"},{id:"171755",title:"Ph.D. Student",name:"Yue",surname:"Dong",slug:"yue-dong",fullName:"Yue Dong"},{id:"171845",title:"Dr.",name:"Jana",surname:"Holm",slug:"jana-holm",fullName:"Jana Holm"}],corrections:null},{id:"48453",title:"Pyridinium-Based Ionic Liquids — Application for Cellulose Processing",doi:"10.5772/59286",slug:"pyridinium-based-ionic-liquids-application-for-cellulose-processing",totalDownloads:1579,totalCrossrefCites:3,totalDimensionsCites:5,hasAltmetrics:0,abstract:null,signatures:"Elena S. Sashina and Dmitrii A. Kashirskii",downloadPdfUrl:"/chapter/pdf-download/48453",previewPdfUrl:"/chapter/pdf-preview/48453",authors:[{id:"171477",title:"Prof.",name:"Elena",surname:"Sashina",slug:"elena-sashina",fullName:"Elena Sashina"},{id:"171890",title:"Mr.",name:"Dmitrii",surname:"Kashirskii",slug:"dmitrii-kashirskii",fullName:"Dmitrii Kashirskii"}],corrections:null},{id:"48449",title:"Utilization of Ionic Liquids in Wood and Wood-Related Applications — A Review",doi:"10.5772/59079",slug:"utilization-of-ionic-liquids-in-wood-and-wood-related-applications-a-review",totalDownloads:1657,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Samir I. Abu-Eishah",downloadPdfUrl:"/chapter/pdf-download/48449",previewPdfUrl:"/chapter/pdf-preview/48449",authors:[{id:"51333",title:"Prof.",name:"Samir",surname:"I. Abu-Eishah",slug:"samir-i.-abu-eishah",fullName:"Samir I. Abu-Eishah"}],corrections:null},{id:"48450",title:"Ionic Liquid as Green Solvent for Ring-Opening Graft Polymerizaion of ε-Caprolactone onto Hemicelluloses",doi:"10.5772/59679",slug:"ionic-liquid-as-green-solvent-for-ring-opening-graft-polymerizaion-of-caprolactone-onto-hemicellulos",totalDownloads:1398,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"X.Q. Zhang, M.J. Chen, H.H. Wang, X.X. Wen, C.F. Liu and R.C. Sun",downloadPdfUrl:"/chapter/pdf-download/48450",previewPdfUrl:"/chapter/pdf-preview/48450",authors:[{id:"19012",title:"Dr.",name:"Chuan-Fu",surname:"Liu",slug:"chuan-fu-liu",fullName:"Chuan-Fu Liu"}],corrections:null},{id:"48468",title:"Electrochemical Preparation of Titanium and its Alloy in Ionic Liquid",doi:"10.5772/59141",slug:"electrochemical-preparation-of-titanium-and-its-alloy-in-ionic-liquid",totalDownloads:1954,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Cunying Xu and Yixin Hua",downloadPdfUrl:"/chapter/pdf-download/48468",previewPdfUrl:"/chapter/pdf-preview/48468",authors:[{id:"171878",title:"Dr.",name:"Cunying",surname:"Xu",slug:"cunying-xu",fullName:"Cunying Xu"},{id:"171880",title:"Prof.",name:"Yixin",surname:"Hua",slug:"yixin-hua",fullName:"Yixin Hua"}],corrections:null},{id:"48462",title:"High-Performance Supercapacitors Based on Ionic Liquids and a Graphene Nanostructure",doi:"10.5772/59201",slug:"high-performance-supercapacitors-based-on-ionic-liquids-and-a-graphene-nanostructure",totalDownloads:3942,totalCrossrefCites:7,totalDimensionsCites:11,hasAltmetrics:0,abstract:null,signatures:"Elaheh Kowsari",downloadPdfUrl:"/chapter/pdf-download/48462",previewPdfUrl:"/chapter/pdf-preview/48462",authors:[{id:"16210",title:"Dr.",name:"Elaheh",surname:"Kowsari",slug:"elaheh-kowsari",fullName:"Elaheh Kowsari"}],corrections:null},{id:"48448",title:"Vibrational Spectroscopic Study on Lubrication and Corrosive Wear Mechanisms of Imidazolium Based Ionic Liquids",doi:"10.5772/59132",slug:"vibrational-spectroscopic-study-on-lubrication-and-corrosive-wear-mechanisms-of-imidazolium-based-io",totalDownloads:1459,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Seiya Watanabe, Miki Nakano, Koji Miyake, Chiharu Tadokoro and\nShinya Sasaki",downloadPdfUrl:"/chapter/pdf-download/48448",previewPdfUrl:"/chapter/pdf-preview/48448",authors:[{id:"153602",title:"Prof.",name:"Shinya",surname:"Sasaki",slug:"shinya-sasaki",fullName:"Shinya Sasaki"}],corrections:null},{id:"48459",title:"Ionic Liquids Applied to Improve the Dispersion of Solids in Elastomers",doi:"10.5772/58980",slug:"ionic-liquids-applied-to-improve-the-dispersion-of-solids-in-elastomers",totalDownloads:1540,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Magdalena Maciejewska and Marian Zaborski",downloadPdfUrl:"/chapter/pdf-download/48459",previewPdfUrl:"/chapter/pdf-preview/48459",authors:[{id:"139343",title:"Dr.",name:"Magdalena",surname:"Maciejewska",slug:"magdalena-maciejewska",fullName:"Magdalena Maciejewska"},{id:"141463",title:"Prof.",name:"Marian",surname:"Zaborski",slug:"marian-zaborski",fullName:"Marian Zaborski"}],corrections:null},{id:"48452",title:"Ionic Liquids in the Vulcanization of Elastomers",doi:"10.5772/59064",slug:"ionic-liquids-in-the-vulcanization-of-elastomers",totalDownloads:1700,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Magdalena Maciejewska and Filip Walkiewicz",downloadPdfUrl:"/chapter/pdf-download/48452",previewPdfUrl:"/chapter/pdf-preview/48452",authors:[{id:"139343",title:"Dr.",name:"Magdalena",surname:"Maciejewska",slug:"magdalena-maciejewska",fullName:"Magdalena Maciejewska"},{id:"171685",title:"Dr.",name:"Filip",surname:"Walkiewicz",slug:"filip-walkiewicz",fullName:"Filip Walkiewicz"}],corrections:null},{id:"48456",title:"Ionic Liquids Facilitate the Development of Absorption Refrigeration",doi:"10.5772/58982",slug:"ionic-liquids-facilitate-the-development-of-absorption-refrigeration",totalDownloads:1435,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Shiqiang Liang, Wei Chen, Yongxian Guo and Dawei Tang",downloadPdfUrl:"/chapter/pdf-download/48456",previewPdfUrl:"/chapter/pdf-preview/48456",authors:[{id:"54609",title:"Dr.",name:"Liang",surname:"Shiqiang",slug:"liang-shiqiang",fullName:"Liang Shiqiang"}],corrections:null},{id:"48457",title:"New Class of Ionic Liquids for Dye-Sensitized Solar Cells",doi:"10.5772/59057",slug:"new-class-of-ionic-liquids-for-dye-sensitized-solar-cells",totalDownloads:1635,totalCrossrefCites:4,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Chun-Ting Li, Ling-Yu Chang, Miao-Syuan Fan, Pei-Yu Chen, Jiang–\nJen Lin, Kuo–Chuan Ho and Chuan-Pei Lee",downloadPdfUrl:"/chapter/pdf-download/48457",previewPdfUrl:"/chapter/pdf-preview/48457",authors:[{id:"5989",title:"Prof.",name:"Kuo-Chuan",surname:"Ho",slug:"kuo-chuan-ho",fullName:"Kuo-Chuan Ho"},{id:"6808",title:"Prof.",name:"Jiang-Jen",surname:"Lin",slug:"jiang-jen-lin",fullName:"Jiang-Jen Lin"},{id:"30213",title:"Dr.",name:"Chuan-Pei",surname:"Lee",slug:"chuan-pei-lee",fullName:"Chuan-Pei Lee"},{id:"165641",title:"Dr.",name:"Ling-Yu",surname:"Chang",slug:"ling-yu-chang",fullName:"Ling-Yu Chang"},{id:"171862",title:"MSc.",name:"Chun-Ting",surname:"Li",slug:"chun-ting-li",fullName:"Chun-Ting Li"},{id:"171863",title:"BSc.",name:"Pei-Yu",surname:"Chen",slug:"pei-yu-chen",fullName:"Pei-Yu Chen"},{id:"171864",title:"MSc.",name:"Miao-Syuan",surname:"Fan",slug:"miao-syuan-fan",fullName:"Miao-Syuan Fan"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"1300",title:"Applications of Ionic Liquids in Science and Technology",subtitle:null,isOpenForSubmission:!1,hash:"45c85b0f82277e20691ffd487d5fecd6",slug:"applications-of-ionic-liquids-in-science-and-technology",bookSignature:"Scott Handy",coverURL:"https://cdn.intechopen.com/books/images_new/1300.jpg",editedByType:"Edited by",editors:[{id:"42658",title:"Prof.",name:"Scott",surname:"Handy",slug:"scott-handy",fullName:"Scott Handy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"327",title:"Ionic Liquids",subtitle:"Classes and Properties",isOpenForSubmission:!1,hash:"659a4b5cbf7f388a9e559b5b558006ca",slug:"ionic-liquids-classes-and-properties",bookSignature:"Scott T. Handy",coverURL:"https://cdn.intechopen.com/books/images_new/327.jpg",editedByType:"Edited by",editors:[{id:"42658",title:"Prof.",name:"Scott",surname:"Handy",slug:"scott-handy",fullName:"Scott Handy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5381",title:"Ionic Liquids",subtitle:"Progress and Developments in",isOpenForSubmission:!1,hash:"e87c37c4d014c11121453605e6d0f37a",slug:"progress-and-developments-in-ionic-liquids",bookSignature:"Scott Handy",coverURL:"https://cdn.intechopen.com/books/images_new/5381.jpg",editedByType:"Edited by",editors:[{id:"42658",title:"Prof.",name:"Scott",surname:"Handy",slug:"scott-handy",fullName:"Scott Handy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3178",title:"Ionic Liquids",subtitle:"New Aspects for the Future",isOpenForSubmission:!1,hash:"2ef68ccc1945a4fc50c6c212bc2f0bd3",slug:"ionic-liquids-new-aspects-for-the-future",bookSignature:"Jun-ichi Kadokawa",coverURL:"https://cdn.intechopen.com/books/images_new/3178.jpg",editedByType:"Edited by",editors:[{id:"16342",title:"Dr.",name:"Jun-ichi",surname:"Kadokawa",slug:"jun-ichi-kadokawa",fullName:"Jun-ichi Kadokawa"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10573",title:"Computational Overview of Fluid Structure Interaction",subtitle:null,isOpenForSubmission:!1,hash:"3950d1f9c82160d23bc594d00ec2ffbb",slug:"computational-overview-of-fluid-structure-interaction",bookSignature:"Khaled Ghaedi, Ahmed Alhusseny, Adel Nasser and Nabeel Al-Zurf",coverURL:"https://cdn.intechopen.com/books/images_new/10573.jpg",editedByType:"Edited by",editors:[{id:"190572",title:"Dr.",name:"Khaled",surname:"Ghaedi",slug:"khaled-ghaedi",fullName:"Khaled Ghaedi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9386",title:"Direct Numerical Simulations",subtitle:"An Introduction and Applications",isOpenForSubmission:!1,hash:"158a3a0fdba295d21ff23326f5a072d5",slug:"direct-numerical-simulations-an-introduction-and-applications",bookSignature:"Srinivasa Rao",coverURL:"https://cdn.intechopen.com/books/images_new/9386.jpg",editedByType:"Edited by",editors:[{id:"6897",title:"Dr.",name:"Srinivasa",surname:"Rao",slug:"srinivasa-rao",fullName:"Srinivasa Rao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10080",title:"Vortex Dynamics Theories and Applications",subtitle:null,isOpenForSubmission:!1,hash:"ea97962e99b3e0ebc9b46b48ba5bea14",slug:"vortex-dynamics-theories-and-applications",bookSignature:"Zambri Harun",coverURL:"https://cdn.intechopen.com/books/images_new/10080.jpg",editedByType:"Edited by",editors:[{id:"243152",title:"Dr.",name:"Zambri",surname:"Harun",slug:"zambri-harun",fullName:"Zambri Harun"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9201",title:"Advanced Supercritical Fluids Technologies",subtitle:null,isOpenForSubmission:!1,hash:"6d02d813b504c90761f9d0abca79106f",slug:"advanced-supercritical-fluids-technologies",bookSignature:"Igor Pioro",coverURL:"https://cdn.intechopen.com/books/images_new/9201.jpg",editedByType:"Edited by",editors:[{id:"15933",title:"Prof.",name:"Igor",surname:"Pioro",slug:"igor-pioro",fullName:"Igor Pioro"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"74443",slug:"corrigendum-to-fruit-flies-diptera-tephritoidea-biology-host-plants-natural-enemies-and-the-implicat",title:"Corrigendum to: Fruit Flies (Diptera: Tephritoidea): Biology, Host Plants, Natural Enemies, and the Implications to Their Natural Control",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/74443.pdf",downloadPdfUrl:"/chapter/pdf-download/74443",previewPdfUrl:"/chapter/pdf-preview/74443",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/74443",risUrl:"/chapter/ris/74443",chapter:{id:"29609",slug:"fruit-flies-diptera-tephritoidea-biology-host-plants-natural-enemies-and-the-implications-to-their-n",signatures:"M. A. Uchoa",dateSubmitted:"March 31st 2011",dateReviewed:"September 21st 2011",datePrePublished:null,datePublished:"February 24th 2012",book:{id:"874",title:"Integrated Pest Management and Pest Control",subtitle:"Current and Future Tactics",fullTitle:"Integrated Pest Management and Pest Control - Current and Future Tactics",slug:"integrated-pest-management-and-pest-control-current-and-future-tactics",publishedDate:"February 24th 2012",bookSignature:"Marcelo L. Larramendy and Sonia Soloneski",coverURL:"https://cdn.intechopen.com/books/images_new/874.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"14863",title:"Dr.",name:"Sonia",middleName:null,surname:"Soloneski",slug:"sonia-soloneski",fullName:"Sonia Soloneski"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"87919",title:"Dr.",name:"Manoel",middleName:null,surname:"Uchoa",fullName:"Manoel Uchoa",slug:"manoel-uchoa",email:"uchoa.manoel@gmail.com",position:null,institution:{name:"Universidade Federal da Grande Dourados",institutionURL:null,country:{name:"Brazil"}}}]}},chapter:{id:"29609",slug:"fruit-flies-diptera-tephritoidea-biology-host-plants-natural-enemies-and-the-implications-to-their-n",signatures:"M. A. Uchoa",dateSubmitted:"March 31st 2011",dateReviewed:"September 21st 2011",datePrePublished:null,datePublished:"February 24th 2012",book:{id:"874",title:"Integrated Pest Management and Pest Control",subtitle:"Current and Future Tactics",fullTitle:"Integrated Pest Management and Pest Control - Current and Future Tactics",slug:"integrated-pest-management-and-pest-control-current-and-future-tactics",publishedDate:"February 24th 2012",bookSignature:"Marcelo L. Larramendy and Sonia Soloneski",coverURL:"https://cdn.intechopen.com/books/images_new/874.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"14863",title:"Dr.",name:"Sonia",middleName:null,surname:"Soloneski",slug:"sonia-soloneski",fullName:"Sonia Soloneski"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"87919",title:"Dr.",name:"Manoel",middleName:null,surname:"Uchoa",fullName:"Manoel Uchoa",slug:"manoel-uchoa",email:"uchoa.manoel@gmail.com",position:null,institution:{name:"Universidade Federal da Grande Dourados",institutionURL:null,country:{name:"Brazil"}}}]},book:{id:"874",title:"Integrated Pest Management and Pest Control",subtitle:"Current and Future Tactics",fullTitle:"Integrated Pest Management and Pest Control - Current and Future Tactics",slug:"integrated-pest-management-and-pest-control-current-and-future-tactics",publishedDate:"February 24th 2012",bookSignature:"Marcelo L. Larramendy and Sonia Soloneski",coverURL:"https://cdn.intechopen.com/books/images_new/874.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"14863",title:"Dr.",name:"Sonia",middleName:null,surname:"Soloneski",slug:"sonia-soloneski",fullName:"Sonia Soloneski"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"7761",leadTitle:null,title:"Advances in Spacecraft Attitude Control",subtitle:null,reviewType:"peer-reviewed",abstract:"Spacecraft attitude maneuvers comply with Euler's moment equations, a set of three nonlinear, coupled differential equations. Nonlinearities complicate the mathematical treatment of the seemingly simple action of rotating, and these complications lead to a robust lineage of research. This book is meant for basic scientifically inclined readers, and commences with a chapter on the basics of spaceflight and leverages this remediation to reveal very advanced topics to new spaceflight enthusiasts. The topics learned from reading this text will prepare students and faculties to investigate interesting spaceflight problems in an era where cube satellites have made such investigations attainable by even small universities. It is the fondest hope of the editor and authors that readers enjoy this book.",isbn:"978-1-78984-803-8",printIsbn:"978-1-78984-802-1",pdfIsbn:"978-1-83968-516-3",doi:"10.5772/intechopen.77574",price:119,priceEur:129,priceUsd:155,slug:"advances-in-spacecraft-attitude-control",numberOfPages:284,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"933b56622351819a21f036a4295e45c2",bookSignature:"Timothy Sands",publishedDate:"January 15th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/7761.jpg",keywords:null,numberOfDownloads:9587,numberOfWosCitations:5,numberOfCrossrefCitations:8,numberOfDimensionsCitations:11,numberOfTotalCitations:24,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 16th 2018",dateEndSecondStepPublish:"March 22nd 2019",dateEndThirdStepPublish:"June 8th 2019",dateEndFourthStepPublish:"August 16th 2019",dateEndFifthStepPublish:"October 15th 2019",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!0,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"258189",title:"Prof.",name:"Timothy",middleName:null,surname:"Sands",slug:"timothy-sands",fullName:"Timothy Sands",profilePictureURL:"https://mts.intechopen.com/storage/users/258189/images/system/258189.jpg",biography:"Dr. Timothy Sands graduated from Columbia University, Stanford University, and the Naval Postgraduate School. He is an Interna-tional Scholar Laureate of the Golden Key International Honor Society, a Fellow of the Defense Advanced Research Projects Agency, panelist of the National Science Foundation Graduate Research Fellowship program, and an interviewer for undergradu-ate admissions at Stanford University. He has published prolifically in archival journals, conference proceedings, books, and book chapters, in addition to giving plenary, keynote, and invitational presentations. He holds one patent in spacecraft attitude control. He is currently the Associate Dean of the Naval Postgrad-uate School’s Graduate School of Engineering and Applied Science having previously served as a university chief academic officer, dean, and research center director.",institutionString:"Cornell University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Stanford University",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"682",title:"Aerodynamics",slug:"aerospace-engineering-aerodynamics"}],chapters:[{id:"69603",title:"Introduction to Satellite Attitude Control",slug:"introduction-to-satellite-attitude-control",totalDownloads:1358,totalCrossrefCites:1,authors:[{id:"290765",title:"Mr.",name:"Henry",surname:"Travis",slug:"henry-travis",fullName:"Henry Travis"}]},{id:"70364",title:"Kinematics: On Direction Cosine Matrices",slug:"kinematics-on-direction-cosine-matrices",totalDownloads:736,totalCrossrefCites:0,authors:[{id:"280356",title:"M.Sc.",name:"Brendon",surname:"Smeresky",slug:"brendon-smeresky",fullName:"Brendon Smeresky"},{id:"280360",title:"BSc.",name:"Alexa",surname:"Rizzo",slug:"alexa-rizzo",fullName:"Alexa Rizzo"}]},{id:"68143",title:"Quaternion-Based Spacecraft Dynamic Modeling and Reorientation Control Using the Dynamically Equivalent Manipulator Approach",slug:"quaternion-based-spacecraft-dynamic-modeling-and-reorientation-control-using-the-dynamically-equival",totalDownloads:688,totalCrossrefCites:2,authors:[{id:"298547",title:"Prof.",name:"Elżbieta",surname:"Jarzębowska",slug:"elzbieta-jarzebowska",fullName:"Elżbieta Jarzębowska"},{id:"305308",title:"M.Sc.",name:"Marcin",surname:"Kłak",slug:"marcin-klak",fullName:"Marcin Kłak"}]},{id:"69575",title:"An Overview of Evolutionary Algorithms toward Spacecraft Attitude Control",slug:"an-overview-of-evolutionary-algorithms-toward-spacecraft-attitude-control",totalDownloads:828,totalCrossrefCites:1,authors:[{id:"279323",title:"Mr.",name:"Matthew",surname:"Cooper",slug:"matthew-cooper",fullName:"Matthew Cooper"}]},{id:"68103",title:"Spacecraft Guidance Sensing at Relativistic Velocities",slug:"spacecraft-guidance-sensing-at-relativistic-velocities",totalDownloads:646,totalCrossrefCites:0,authors:[{id:"295287",title:"Prof.",name:"Emanuele",surname:"Calabrò",slug:"emanuele-calabro",fullName:"Emanuele Calabrò"}]},{id:"68120",title:"Analysis and Control of Nonlinear Attitude Motion of Gravity-Gradient Stabilized Spacecraft via Lyapunov-Floquet Transformation and Normal Forms",slug:"analysis-and-control-of-nonlinear-attitude-motion-of-gravity-gradient-stabilized-spacecraft-via-lyap",totalDownloads:688,totalCrossrefCites:1,authors:[{id:"268064",title:"Prof.",name:"Sangram",surname:"Redkar",slug:"sangram-redkar",fullName:"Sangram Redkar"},{id:"299165",title:"Ph.D. Student",name:"Peter",surname:"Waswa",slug:"peter-waswa",fullName:"Peter Waswa"}]},{id:"67273",title:"Optimal Trajectory Synthesis and Tracking Control for Spacecraft Large Attitude Manoeuvers",slug:"optimal-trajectory-synthesis-and-tracking-control-for-spacecraft-large-attitude-manoeuvers",totalDownloads:587,totalCrossrefCites:0,authors:[{id:"180724",title:"Dr.",name:"Ranjan",surname:"Vepa",slug:"ranjan-vepa",fullName:"Ranjan Vepa"}]},{id:"69272",title:"Parameter Optimization for Spacecraft Attitude Stabilization Using Magnetorquers",slug:"parameter-optimization-for-spacecraft-attitude-stabilization-using-magnetorquers",totalDownloads:524,totalCrossrefCites:0,authors:[{id:"296167",title:"Prof.",name:"Renato",surname:"Bruni",slug:"renato-bruni",fullName:"Renato Bruni"},{id:"296538",title:"Dr.",name:"Fabio",surname:"Celani",slug:"fabio-celani",fullName:"Fabio Celani"}]},{id:"70008",title:"Precise Attitude Control Techniques: Performance Analysis From Classical to Variable Structure Control",slug:"precise-attitude-control-techniques-performance-analysis-from-classical-to-variable-structure-contro",totalDownloads:746,totalCrossrefCites:2,authors:[{id:"295412",title:"Dr.",name:"Elisa",surname:"Capello",slug:"elisa-capello",fullName:"Elisa Capello"},{id:"298346",title:"Dr.",name:"Matteo",surname:"Dentis",slug:"matteo-dentis",fullName:"Matteo Dentis"}]},{id:"68151",title:"Investigation of Singularities in a 3/4 CMG Configuration with Mixed Skew Angles",slug:"investigation-of-singularities-in-a-3-4-cmg-configuration-with-mixed-skew-angles",totalDownloads:497,totalCrossrefCites:0,authors:[{id:"290754",title:"Mr.",name:"Jonathan",surname:"Lang",slug:"jonathan-lang",fullName:"Jonathan Lang"}]},{id:"70365",title:"Control Moment Gyroscope Skew Angle Variation and Singularity Penetration",slug:"control-moment-gyroscope-skew-angle-variation-and-singularity-penetration",totalDownloads:609,totalCrossrefCites:1,authors:[{id:"281178",title:"M.Sc.",name:"Kyle",surname:"Baker",slug:"kyle-baker",fullName:"Kyle Baker"}]},{id:"67835",title:"Single Axis Singularity Mapping for Mixed Skew Angle, Non-Redundant, Single Gimbaled CMG Systems",slug:"single-axis-singularity-mapping-for-mixed-skew-angle-non-redundant-single-gimbaled-cmg-systems",totalDownloads:543,totalCrossrefCites:0,authors:[{id:"294534",title:"B.Sc.",name:"Eryn",surname:"Culton",slug:"eryn-culton",fullName:"Eryn Culton"}]},{id:"67815",title:"Momentum Space Analysis for Mixed Skew Angle Arrays",slug:"momentum-space-analysis-for-mixed-skew-angle-arrays",totalDownloads:557,totalCrossrefCites:0,authors:[{id:"290833",title:"B.Sc.",name:"Zachary",surname:"Lewis",slug:"zachary-lewis",fullName:"Zachary Lewis"}]},{id:"69734",title:"Mixed Skew Angle Singularity Plotting for Non-Redundant Single Gimbal CMG Array",slug:"mixed-skew-angle-singularity-plotting-for-non-redundant-single-gimbal-cmg-array",totalDownloads:580,totalCrossrefCites:0,authors:[{id:"291232",title:"B.Sc.",name:"Joshua",surname:"Ten Eyck",slug:"joshua-ten-eyck",fullName:"Joshua Ten Eyck"}]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"177730",firstName:"Edi",lastName:"Lipovic",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/177730/images/4741_n.jpg",email:"edi@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"8841",title:"Deterministic Artificial Intelligence",subtitle:null,isOpenForSubmission:!1,hash:"bd65f564ea0b77f91dea36cfcbaa1da7",slug:"deterministic-artificial-intelligence",bookSignature:"Timothy Sands",coverURL:"https://cdn.intechopen.com/books/images_new/8841.jpg",editedByType:"Edited by",editors:[{id:"258189",title:"Prof.",name:"Timothy",surname:"Sands",slug:"timothy-sands",fullName:"Timothy Sands"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5847",title:"Aerial Robots",subtitle:"Aerodynamics, Control and Applications",isOpenForSubmission:!1,hash:"340f32fcf4dae90d01d22d6a394b9d85",slug:"aerial-robots-aerodynamics-control-and-applications",bookSignature:"Omar Dario Lopez Mejia and Jaime Alberto Escobar Gomez",coverURL:"https://cdn.intechopen.com/books/images_new/5847.jpg",editedByType:"Edited by",editors:[{id:"186649",title:"Dr.",name:"Omar",surname:"Lopez Mejia",slug:"omar-lopez-mejia",fullName:"Omar Lopez Mejia"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5801",title:"Turbulence Modelling Approaches",subtitle:"Current State, Development Prospects, Applications",isOpenForSubmission:!1,hash:"806f8c12f61aee260f439635c576baf8",slug:"turbulence-modelling-approaches-current-state-development-prospects-applications",bookSignature:"Konstantin Volkov",coverURL:"https://cdn.intechopen.com/books/images_new/5801.jpg",editedByType:"Edited by",editors:[{id:"118184",title:"Dr.",name:"Konstantin",surname:"Volkov",slug:"konstantin-volkov",fullName:"Konstantin Volkov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8558",title:"Aerodynamics",subtitle:null,isOpenForSubmission:!1,hash:"db7263fc198dfb539073ba0260a7f1aa",slug:"aerodynamics",bookSignature:"Mofid Gorji-Bandpy and Aly-Mousaad Aly",coverURL:"https://cdn.intechopen.com/books/images_new/8558.jpg",editedByType:"Edited by",editors:[{id:"35542",title:"Prof.",name:"Mofid",surname:"Gorji-Bandpy",slug:"mofid-gorji-bandpy",fullName:"Mofid Gorji-Bandpy"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8643",title:"Hypersonic Vehicles",subtitle:"Past, Present and Future Developments",isOpenForSubmission:!1,hash:"c8b071f76d5ebaa5d249d728be4f42dd",slug:"hypersonic-vehicles-past-present-and-future-developments",bookSignature:"Giuseppe Pezzella and Antonio Viviani",coverURL:"https://cdn.intechopen.com/books/images_new/8643.jpg",editedByType:"Edited by",editors:[{id:"14939",title:"Prof.",name:"Giuseppe",surname:"Pezzella",slug:"giuseppe-pezzella",fullName:"Giuseppe Pezzella"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"68830",title:"PET-CT Principles and Applications in Lung Cancer Management",doi:"10.5772/intechopen.88717",slug:"pet-ct-principles-and-applications-in-lung-cancer-management",body:'\n
Totally lung cancer remains the first leading cause of cancer incidence and mortality, with about 2.1 million incidence and 1.8 million deaths in 2018 among 185 countries [1]. In 2018, an estimated 234,030 new cases of lung and bronchial cancer will be diagnosed, and 154,050 deaths are estimated to occur because of the disease [2]. The 5-year over survival rate is <20% once diagnosed [3]. Lung cancer is a unique disease for its etiologic agent is an addictive product cigarette, made and produced by an industry. Voluntary or involuntary (secondhand) cigarette smoking leads to nearly 90% cases, suggesting that effective public health policies to prevent initiation of smoking, oversight of tobacco products, and other tobacco control measures will play crucial roles in reducing lung cancer mortality [4]. Increased exposure to smoke from the burning of charcoal for heating and cooking is believed to contribute to the high lung cancer incidence, rather than smoking that is thought to be the leading cause of high lung cancer incidence in western countries [5].
\nThere are four major cell types of lung cancer according to the World Health Organization (WHO) classification: adenocarcinoma (ADC), squamous cell carcinoma (SCC), large cell carcinoma, and small cell carcinoma [6]. The first three types are also called non-small cell lung cancer, consisting of the most majority of all lung cancers. This molecular-based classification is important for therapeutic decision-making for several reasons: (i) overall survival was statistically superior for cisplatin/pemetrexed versus cisplatin/gemcitabine in patients with ADC (12.6 versus 10.9 months, respectively). In contrast, in SCC patients, there was a significant improvement in survival with cisplatin/gemcitabine versus cisplatin/pemetrexed (10.8 versus 9.4 months, respectively) [7]. (ii) SCC patients receiving treatment with carboplatin and paclitaxel plus bevacizumab (15 mg/kg) are prone to suffering from life-threatening major hemoptysis [8]. (iii) ADC patients are likely to harbor epidermal growth factor receptor (EGFR) mutations which are predictive of responsiveness to tyrosine kinase inhibitors (TKI).
\nAge, smoking history, previous cancer history, family history, occupational exposures, other lung diseases (chronic obstructive pulmonary disease [COPD], pulmonary fibrosis), exposure to infectious agents (e.g., endemic areas of fungal infections, tuberculosis) or risk factors, or history suggestive of infection are all potential or obvious risk factors.
\nNeuroendocrine tumors account for about 20% of lung cancers, and most are small cell lung cancer (SCLC) [9]. SCLC is sometimes called oat cell cancer, accounting for approximately 10–15% of lung cancers, and is considered as a separate entity from NSCLC due to its early metastases and relative response to chemotherapy and radiation. Unfortunately, although small cell lung cancer usually responds very well initially to treatment, long-term survival remains low. To be specific, the 5-year survival rate is 31% for stage I, 19% for stage II, 8% for stage IV, and only 2% for stage IV disease. There is no significant difference in the AJCC TNM staging system between NSCLC and SCLC. In fact, in addition to the TNM staging, SCLC can also be defined as “limited stage” when the tumor is encompassed within a tolerable radiation field or defined as “extensive stage” when the tumor is too large or too widespread to be encompassed within tolerable radiation field, according to the older Veterans Administration (VA) [10]. Then the NCCN Panel adopted a combined approach for staging SCLC using both the AJCC TNM staging system and the VA scheme for SCLC. In applying the TNM classifications to the VA system, the so-called limited-stage SCLC is defined as stage I to III (any T, any N, M0) which can be effectively treated with definitive radiation therapy, while extensive-stage SCLC is defined as stage IV (any T, any N, M1a/b) or T3-T4 harboring multiple lung nodules or having tumor volume that is too large to be encompassed in a tolerable radiation plan. Positron emission tomography-computed tomography (PET-CT) scan will be useful to assess for distant metastases when limited-stage disease is suspected, and a bone scan can be performed if PET-CT is ambiguous or not available; bone biopsy can be applied if the bone scan is equivocal. Although PET-CT is superior to PET or CT alone in detecting most metastatic sites, it is inferior to MR for the detection of brain metastases [11].
\nAdenosquamous carcinoma (ASC) is a rare subtype of lung cancer, making up 0.4–4% of all lung cancer cases, and it is made up of two of the main tumor types: adenocarcinoma and squamous [12]. People suffering from ASC are prone to survive within a shorter time than those with pure lung adenocarcinomas or squamous cell carcinomas of the lung, no matter whether it is diagnosed earlier or later. In addition, the proportion of the adenocarcinoma/squamous cell component has no effect on the outcome. Cisplatin (a chemotherapy drug used in the squamous cancer cell) rather than the pemetrexed (commonly used in adenocarcinomas) tends to be more effective in the treatment of ASC. Some studies have shown that ASC has its own clinical characteristics: patients are mainly males, the average age is 68.7 years old, most patients with ASC have smoking history, and most of the diseases are located in the peripheral rather than the central segment [12].
\nCarcinoid tumors are a type of tumor that relates to the neuroendocrine system, accounting for about 1–6% of all lung tumors, and approximately a quarter of patients suffering from carcinoid have no symptoms at the time of discovery. Although a common X-ray or chest CT scan can detect this disease, 18F-FDG PET-CT scans are not sensitive enough to discover it or see if they have spread distantly because no obvious uptake can be discovered. Consequently, octreotide rather than FDG will be given if some are suspected of having a carcinoid tumor [13].
\nGranular cell lung tumors are extremely rare, accounting for approximately 0.2% of all lung tumors. Narrowed airways, which are caused by small, firm, and solitary nodules, can always be found. However, in most situations, this kind of disease is benign. Malignant or cancerous granular cell lung is even rarer [14].
\nSarcomatoid carcinomas are another rare lung carcinoma, making up 0.3–3% of all NSCLC. Some studies have shown that heavy smoking and exposure to asbestos possibly, at least partially, are responsible for this disease [15].
\nTraditionally, according to histological features, NSCLC has been classified into small cell and non-small cell lung cancers and further was subdivided into squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Historically, little attention was given to the differentiation of the specific subtypes because there are no therapeutic implications, especially prior to the 2004 WHO classification. Various driver mutations have been associated with these cancers over time [16]; the genetic alterations and specific protein expression level have attracted much attention (Figure 1).
\nClassifications of lung cancer: from histology to molecular based [
The primary tumor (T), regional lymph node involvement (N), and distant metastasis (M) are the bases of staging for lung cancer. The International Association Society of Lung Cancer (IASLC) recommends the TNM classification of malignant tumors published by the Union Internationale Contre Le Cancer (UICC) and the American Joint Committee on Cancer (AJCC), and the latest eighth edition was published in 2016 [17]. Based on the different T, N, and M combinations, patients are grouped into different stages, which will determine the clinical treatments and can also predict various prognoses. The staging system is described in Table 1, and the stage groupings based on the TNM are listed in Table 2.
\nT—Primary tumor | \n|
T category | \nT criteria | \n
Tx | \nPrimary tumor cannot be assessed, or tumor proven by the presence of malignant cells in sputum or bronchial washings but not visualized by imaging or bronchoscopy | \n
T0 | \nNo evidence of primary tumor | \n
Tis | \nCarcinoma in situ | \n
Squamous cell carcinoma in situ (SCIS) | \n|
Adenocarcinoma in situ (AIS): adenocarcinoma with pure lepidic pattern, ≤3 cm in greatest dimension | \n|
T1 | \nTumor ≤3 cm in greatest dimension, surrounded by lung or visceral pleura, without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus) | \n
T1mi | \nMinimally invasive adenocarcinoma: adenocarcinoma (≤3 cm in greatest dimension) with a predominantly lepidic pattern and ≤ 5 mm invasion in greatest dimension | \n
T1a | \nTumor ≤1 cm in greatest dimension. A superficial, spreading tumor of any size whose invasive component is limited to the bronchial wall and may extend proximal to the main bronchus; also is classified as T1a, but these tumors are uncommon | \n
T1b | \nTumor >1 cm but ≤2 cm in greatest dimension | \n
T1c | \nTumor >2 cm but ≤3 cm in greatest dimension | \n
T2 | \nTumor >3 cm but ≤5 cm or having any of the following features: \n
| \n
T2a | \nTumor >3 cm but ≤4 cm in greatest dimension | \n
T2b | \nTumor >4 cm but ≤5 cm in greatest dimension | \n
T3 | \nTumor >5 cm but ≤7 cm in greatest dimension or directly invading any of the following: parietal pleura (PL3), chest wall (including superior sulcus tumors), phrenic nerve, parietal pericardium; or separate tumor nodule (s) in the same lobe as the primary | \n
T4 | \nTumor >7 cm or tumor of any size invading one or more of the following: the diaphragm, mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, or carina; separate tumor nodule(s) in an ipsilateral lobe different from that of the primary | \n
N—Regional lymph | \n|
N category | \nN criteria | \n
NX | \nRegional lymph nodes cannot be assessed | \n
N0 | \nNo regional lymph node metastasis | \n
N1 | \nMetastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension | \n
N2 | \nMetastasis in ipsilateral mediastinal and/or subcarinal lymph node(s) | \n
N3 | \nMetastasis in contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s) | \n
M category | \nM criteria | \n
M0 | \nNo distant metastasis | \n
M1 | \nDistant metastasis | \n
M1a | \nSeparate tumor nodule(s) in a contralateral lobe; tumor with pleural or pericardial nodules or malignant pleural or pericardial effusion. Most pleural (pericardial) effusions with lung cancer are a result of the tumor. In a few patients, however, multiple microscopic examinations of pleural (pericardial) fluid are negative for tumor, and the fluid is nonbloody and not an exudate. If these elements and clinical judgment dictate that the effusion is not related to the tumor, the effusion should be excluded as a staging descriptor | \n
M1b | \nSingle extrathoracic metastasis in a single organ (including involvement of a single nonregional node) | \n
M1c | \nMultiple extrathoracic metastases in a single organ or in multiple organs | \n
The eighth edition of TNM for lung cancer.
Stage group | \nT | \nN | \nM | \n
---|---|---|---|
Stage IA | \nT1 | \nN0 | \nM0 | \n
Stage IA1 | \nT1mi, T1a | \nN0 | \nM0 | \n
Stage IA2 | \nT1b | \nN0 | \nM0 | \n
Stage IA3 | \nT1c | \nN0 | \nM0 | \n
Stage IB | \nT2a | \nN0 | \nM0 | \n
Stage IIA | \nT2b | \nN0 | \nM0 | \n
Stage IIB | \nT1a-c, T2a, b | \nN1 | \nM0 | \n
T3 | \nN0 | \nM0 | \n|
Stage IIIA | \nT1a-c, T2a, b | \nN2 | \nM0 | \n
T3 | \nN1 | \nM0 | \n|
T4 | \nN0, N1 | \nM0 | \n|
Stage IIIB | \nT1a-c, T2a, b | \nN3 | \nM0 | \n
T3, T4 | \nN2 | \nM0 | \n|
Stage IIIC | \nT3, T4 | \nN3 | \nM0 | \n
Stage IVA | \nAny T | \nAny N | \nM1a, b | \n
Stage IVB | \nAny T | \nAny N | \nM1c | \n
Stage groupings in the eighth edition of TNM staging system for lung cancer.
Synoptic reporting for lung cancer aimed to standardize diagnostic reports, including recommended clinical and histopathologic variables. This includes the clinical details and macroscopic, microscopic, and pathological staging as essential requirements. In addition, there should be an assessment of lymphovascular invasion and neurotropism and the presence of absence of satellite lesions; all these are shown in Table 3.
\nTerms | \n
---|
Clinical details | \n
Clinical information provided on request Nature of the resection Additional extrapulmonary tissue Site and laterality of tumor Results of previous cytological investigations or biopsies Details of any previous treatment of the current tumor Details of previous cancer diagnosis Risk factors for lung cancer (e.g., smoking history, ethnicity, and asbestos exposure) Clinical tumor stage New primary cancer or recurrence Pathology accession number Principal clinician caring for the patient Other clinical information received | \n
Macroscopic Operative procedure Specimen laterality Attached anatomical structures Accompanying specimens Block identification key Tumor site Tumor location Separate tumor nodules Maximum tumor dimension Macroscopic appearance of pleura overlying tumor Extent of direct spread of tumor to other tissues Distance of tumor to closest resection margin Tumor involves main bronchus within 20 mm of carina Lymph nodes Atelectasis/obstructive pneumonitis Nonneoplastic lung Other relevant information and comments | \n
Microscopic Histological tumor type Histological grade Visceral pleural invasion Lymphovascular invasion Perineural invasion | \n
Pathological staging (AJCC seventh edition) Suffixes Primary tumor (T) Regional lymph nodes (N) Distant metastasis (M) Residual tumor status Completeness of surgical resection Diagnostic summary | \n
Synoptic reporting of lung cancer.
Generally speaking, surgery is the best chance for stage I or II lung cancer patients [18]. Surgical oncology consultation is necessary for any patient being considered for local therapy. The general treatment plan, the essential imaging studies, and laboratory results should be determined before any nonemergency treatment is started. If patients cannot tolerate surgery or are inoperable, minimally invasive techniques, such as sublobar resection, can be a better choice [19]. Selected patients, including those who are not eligible for lobectomy and those with a peripheral nodule 2 cm or less with very low-risk features, are recommended to go through sublobar resection, either segmentectomy (preferred) or wedge resection. On the other hand, segmentectomy (preferred) or wedge resection should achieve parenchymal resection margins that are (1) 2 cm or more or (2) the size of the nodule or more.
\nThe principles of radiation therapy in the NSCLC algorithm has been described thoroughly, including the following: general principles for early-stage, locally advanced, and advanced NSCLC; target volumes, prescription doses, and normal tissue dose constraints for early-stage, locally advanced, and advanced NSCLC; and RT simulation, planning, and delivery [20]. Treatment recommendations should be made by a multidisciplinary team. Because of the potential role of radiotherapy in all stages of NSCLC, whether it is a definitive treatment or palliative treatment is not known. Radiotherapy uses for NSCLC include, but are not limited to, (1) definitive treatment of locally advanced NSCLC, usually combined with chemotherapy; (2) definitive treatment of early NSCLC in patients with surgical contraindications; (3) partial preoperative or postoperative treatment of surgical patients; (4) treatment of limited recurrence and metastasis; and/or (5) palliative treatment of incurable NSCLC patients [21, 22, 23].
\nSpecific targeted therapies can be used to treat advanced NSCLC. Bevacizumab is a monoclonal antibody, targeting vascular endothelial growth factor, while ramucirumab is a recombinant monoclonal antibody that targets VEGF receptors. Cetuximab is a monoclonal antibody that targets EGFR. Erlotinib, gefitinib, and afatinib inhibit EGFR-sensitizing mutations; osimertinib inhibits both EGFR-sensitizing mutations and T790 M. ALK rearrangement, ROS1 rearrangement, and MET were all inhibited by crizotinib. Patients with ALK rearrangement are recommended to ceritinib which inhibits the IGF-1 receptor. Alectinib inhibits ALK and RET rearrangement. Brigatinib inhibits various ALK rearrangements and other targets. Dabrafenib/trametinib inhibits the BRAF V600E mutation; trametinib also inhibits MEK; both drugs inhibit different kinases in the RAS/RAF/MEK/ERK pathway [24, 25].
\nPET-CT is a nuclear medicine technique that combines a positron emission tomography (PET) scanner with an X-ray computed tomography (CT) scanner. The anatomical imaging obtained by CT scan and the functional imaging obtained by PET (which depicts the spatial distribution of metabolic or biochemical activity in vivo) can achieve the same machine fusion more accurately, and the generated fusion image can be based on general software and control system to obtain 2D and 3D image reconstruction. Previously pure PET imaging cannot provide accurate anatomical positioning, and thus its value was limited, while PET-CT revolutionized medical diagnosis in many areas by increasing the accuracy of anatomical positioning in functional imaging. For example, the diagnosis and classification of benign and malignant tumors, the development of surgical plans, and the delineation of radiotherapy target areas have rapidly changed under the influence of PET-CT availability [26]. PET-CT-based grading staging has significantly changed clinical decisions; so many hospitals’ nuclear medicine departments have gradually reduced the usage of traditional PET devices and replaced them with PET-CT. One of the barriers to the wider use of PET-CT is its relatively expensive price. Another obstacle is the difficulty and cost of producing and transporting of radiopharmaceuticals for PET imaging, which usually have a short half-life (e.g., radioactive fluorine-18). The half-life of (18F) is used to track glucose metabolism (using fluorodeoxyglucose (FDG)) for only 106 minutes, and its production requires very expensive cyclotrons and radiopharmaceutical production lines [27].
\nIdentifying the stage of lung cancer not only helps determine the appropriate treatment but also is essential for prognosis. Incorrect staging of lung cancer can lead to mistaken resections of benign nodules and early local or distant relapse after surgery with curative intent. Barbara randomly assigned patients referred for preoperative staging of NSCLC to either conventional staging plus PET-CT or conventional staging alone followed until death or for at least 12 months. They defined ineffective thoracotomy as any of the following: thoracotomy, pathologically confirmed mediastinal lymph node involvement (stage IIIA [N2]), stage IIIB or IV disease, or benign lung disease; exploratory thoracic incision; or thoracotomy in patients who have relapsed or died for any reason within 1 year after randomization. Ninety-eight patients were assigned to the PET-CT group and 91 to the conventional staging group. Sixty patients in the PET-CT group and 73 in the conventional staging group underwent thoracotomy (P = 0.004). Among these thoracotomies, 21 in the PET-CT group and 38 in the conventional staging group were futile (P = 0.05). Both groups had a reasonable thoracotomy and had similar survival. The use of PET-CT in the preoperative staging of NSCLC reduced the total number of thoracotomy and the number of ineffective thoracotomy, but did not affect overall mortality [28] (Figure 2).
\nPreoperative staging of NSCLC between PET-CT group and conventional staging group.
Franco et al. conducted research aiming to evaluate the utility between PET-CT and the contrast-enhanced (CE) CT. The low-dose CT scans were performed for attenuation correction of the PET images, and the PET scanner was fully cross-calibrated, allowing accurate standard uptake value measurements. The protocols for CE-CT are the following: (1) all chest CT scans were performed according to the conventional low-dose chest multi-detection CT protocol, including head-to-tail orientation, arms raised on the head, single breath, and the amount of scan from the diaphragm level to the level directly above the chest entrance; and (2) the injected volume of contrast medium was tailored to the individual body weight: 60 mL at 2 mL/s for <50 kg or 80 mL at 2.5 mL/s at 50 kg or heavier with a fixed contrast delay of 35 seconds. The study enrolled 96 patients who received curative-intent treatment, and the results showed that the sensitivity, specificity, and positive predictive value for detecting cancer recurrence (95% confidence interval) were 0.88, 0.62, and 0.56 for PET-CT and 0.93, 0.72, and 0.64 for CE-CT, respectively, indicating that PET-CT is not superior to CE-CT in detecting cancer recurrence during 2 years after curative-intent treatment of non-small cell lung cancer [29].
\nUsing systematic review and meta-analysis, Nie et al. evaluated the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) for small cell lung cancer and used the pooled hazard ratio (HR) to measure the influence of MTV and TLG on survival. They found that patients with high MTV are associated with a significantly poorer prognosis OS and PFS, while high TLG is associated with a significantly poorer prognosis regarding OS for SCLC [30].
\nWhen lung cancer is discovered, accurate staging at baseline is necessary to maximize patient benefit and cost-effective use of healthcare resources. Although CT remains a powerful tool for the staging of lung cancer, advances in combined imaging modalities, specifically PET-CT, have improved the baseline staging accuracy over that of CT alone [31]. FDG PET-CT has been considered a “metabolic biopsy” tool in the evaluation of nonlung lesions with indeterminate biopsy results [32]. PET-CT data coregistered with intraprocedural CT images could guide needle placement in the viable portion of the lesion and thus increase the chances of achieving a definitive diagnosis and CT-guided, fine-needle aspiration (FNA) biopsies performed with FDG PET scans of pulmonary lesions contributing substantially to the management and treatment of pulmonary disease [33].
\nTeaching point: adenocarcinoma mainly located in the peripheral segment and shows higher FDG uptake (Figure 3).
\nAxial PET, CT, PET-CT, and MIP images in a patient of adenocarcinoma. An irregular mass showing higher FDG uptake in the lesion was discovered in the anterior segment of the right upper lobar.
Teaching point: adenocarcinoma is mainly located in the central segment and shows moderate FDG uptake (Figure 4).
\nAxial PET, CT, PET-CT, and MIP images in a patient of squamous cell carcinoma. An irregular mass showing moderate FDG uptake in the lesion was discovered in the central segment of the right lung, with inflammation around the malignant lung lesion.
Teaching point: large cell lung cancer always shows moderate FDG uptake and diffused distribution (Figure 5).
\nAxial PET, CT, PET-CT, and MIP images in a patient of large cell cancer. Multisite masses showing higher FDG uptake in the lesion were discovered in the left and right lung field, with inflammation and enlarged lymph node in the mediastinum.
Teaching point: small cell lung cancer shows a small mass with moderate FDG uptake (Figure 6).
\nAxial PET, CT, PET-CT, and MIP images in a patient of small cell lung cancer. Small mass located in the right hilar with slight FDG uptake in the lesion was discovered in the right lung field.
The current chapter focused on the PET-CT utility in lung cancer diagnosis and summarized the basic clinic utilities, including guiding to select the biopsy site, improving target delineation accuracy, evaluating disease progression on first-line therapy, and detecting hilar, mediastinal nodes and metastatic disease. PET-CT scans have been widely used to help evaluate the extent of disease and to provide more accurate staging and has been recommended by the NCCN. Patients with suspected malignant lung nodules should be scanned by PET-CT for accurate diagnosis of local or distant metastasis.
\nThis work is supported by China Postdoctoral Science Foundation (No. 2019M653501), Initiation Foundation for Doctors of Yunnan Cancer Hospital (No. BSKY201706), Joint Special Fund from Yunnan Provincial Science and Technology Department-Kunming Medical University for Applied and Basic Research (No. 2018FE001-150), the National Natural Science Foundation of China (No. 81960496) and the 100 Young and Middle-aged Academic and Technical Backbone Incubation Projects of Kunming Medical University.
\nDental implants have become a predictable and safe form of treatment for the replacement of missing teeth. Surely, implants have revolutionized dentistry practice in worldwide, enabling the rehabilitation of patients who have lost single teeth to patients with loss of all teeth. Thus, various types of treatments made possible by improving the quality of life and patient satisfaction. Among these treatments that had the greatest representation, we can mention: the cases of totally edentulous people, who could receive implants to improve the fixation of removable dentures or even receive fixed dentures; patients with partial losses with a lack of posterior pillars (teeth) who had to wear removable dentures and could receive fixed dentures; and patients who had unit losses where it was possible to rehabilitate them without wearing out natural healthy teeth.
Since its diffusion by Branemark in the 60s [1, 2], dental implants have been the object of many studies and, consequently, have undergone several changes. However, the base material for its manufacture, titanium, continues to be used due to its excellent biological and mechanical characteristics. Surgical techniques have also undergone several advances and modifications. Initially, a waiting time for the beginning of the rehabilitation procedures of 6 months was recommended, with implants installed in the bone tissue and covered by mucosa during this waiting period for osseointegration. With the advancement of knowledge, it was proposed that for implants installed in the mandible, the waiting time could be less than in the maxilla, due to the difference in density between the two anatomical sectors. However, Gehrke and Tavares da Silva Neto [3], showed in a clinical study that the evolution of osseointegration is the same in the 2 types of bone (maxilla and mandible) and that the implants could be loaded in both arches with the same waiting time, as long as these sites who received implants were in adequate condition. On the other hand, new techniques aiming to speed up the treatment time and provide greater comfort to patients, such as post-extraction implants (immediate), immediate loading on the implants, implants with simultaneous bone regeneration, among others, were proposals and studied and, currently, are widely used.
Different changes at nano-, micro- and macro-structural levels have been researched and proposed with the aim of improving and/or accelerating the processes involved in the osseointegration of dental implants. Such possibilities became possible with the evolution of scientific knowledge about the events involved in the healing process of peri-implant tissues after implant insertion. In this sense, several types of surface treatment have been proposed in order to promote a physical–chemical stimulation capable of accelerating the initial phases of bone neoformation on the implant [4, 5]. Among the main methods used to produce surface roughness of implants are the addition processes (e.g., titanium plasma spray, hydroxyapatite coating) and subtraction processes (e.g., acid etching, microparticle blasting, laser). Among all of them, the most used procedure currently by most of the world industry is the subtraction methods, as they have shown good results and are less costly. On the other hand, the addition of ions (e.g., Calcium, Magnesium, hydroxyapatite) on these surfaces at nano- and/or micrometric levels has shown good results for the osseointegration.
Initially, the implants had a cylindrical macrogeometry, being later proposed implants with macrogeometry with conical designs. Tapered shaped implants had advantages over cylindrical ones, especially regarding the surgical process, where they were shown to generate less trauma to the bone tissue resulting from the drilling process used for this type of implant. In addition to this change in the body of the implant body, changes in the shape of the turns, which were initially triangular and with little depth, received other shapes, such as trapezoidal, square, and with greater depth and distance in the thread pitch. Also, changes in the cervical portion of the implants, which are in contact with the cortical bone, have been proposed. Among these changes, we can mention the presence of smooth (polished) surfaces, treated (rough) surfaces and the presence of micro-turns. Regarding the prosthetic connections, the implants had several alterations, being proposed different models of fittings, always with the intention of improving the stability of the rehabilitation in the long term. Figure 1 shows different types of implants and designs proposed in recent decades.
Available dental implants with different design and connections. (courtesy of Implacil De Bortoli company, Brazil).
More recently, with scientific evidence that the installation of implants with less compression of the bone tissue could benefit and accelerate the osseointegration process, new macrogeometric models of implants were proposed. In this sense, it was shown that the presence of free spaces of bone tissue or the presence of uncompressed fragments can facilitate the cellular work of phagocytosis and bone matrix neoformation, as shown schematically in the Figure 2. This type of condition, creating a space between the bone tissue and the implant, is achieved through a modification in the surgical technique, that is, in the relationship between the diameter of the last reamer used and the diameter of the implant to be inserted into the bone. Thus, in this chapter we will describe and discuss some advances resulting from these changes in the structure of dental implants during the last decades.
Schematic image depicting the installation of an implant in a conventional technique (left) causing bone compression over an extensive area, and the implant insertion with spaces between the bone and the implant (right) decreasing bone compression area.
The first dental implants were developed without any type of surface treatment, they were carried out by a machining process, which resulted in implants with a smooth surface. For a long time, this implant was conceived as the gold standard. Experimental studies comparing smooth and rough surfaces demonstrate a better biological response to the latter. With the evolution of implantology, changes in implant surfaces began to be carried out in order to improve osseointegration [6].
The processes of changes in the surface of implants can be carried out by the addition method, when some type of material is added to the layer by means of plasma spray coating, or subtraction, when part of this surface layer is removed by physical and/or chemical processes, such as abrasion by blasting or acid etching [7]. The texturing of the implant surface can influence the osseointegration process both in cell differentiation, after implant placement, and in the amount of calcified bone matrix [7, 8]. Thakral et al. [9], reported that texturing techniques in dental implants can influence the establishment of osseointegration, both for cell differentiation, after implant insertion, and for calcified bone matrix. Also, according to Wennerberg and Albrektsson [10], the treated surfaces result in greater bone/implant contact (BIC), compared to smooth implants. Thus, implants with textured surfaces are indicated for sites with a lower BIC at the end of surgery. On the other hand, Att et al. [11], state that bone is indistinctly deposited on porous or smooth surfaces. Therefore, porosity would not be a necessary condition for bone apposition to occur.
Regarding the initial stability of the implants, the surface treatment of the implants does not change the initial stability values of the implants, as shown in studies comparing the insertion torque and stability analysis by resonance frequency using implants with the same design with and without surface treatment [12, 13].
Machined implants with an untreated surface are considered to have a smooth surface. Machined implants with an untreated surface are considered to have a smooth surface. However, they have small grooves that allow the bone mineralization process towards the implant, but they do not have an osteoinductive surface. This type of surface is considered anisotropic, which is responsible for promoting the cell adhesion process and the production of the protein matrix. The machined implant has a surface roughness between 0.5 μm and 1 μm. This smooth surface is formed a surficial microgroove, resulting from the machining process, produced by the passage of the cutting tool. This type of surface does not receive chemical or mechanical treatment, presenting only the micromorphology of the machining process [9]. Figure 3 shows representative images of a smooth surface at different magnifications.
Representative SEM images with different magnifications of the surface micro grooves resulting from the machining process, produced by the passage of the cutting tool.
Plasma spray is the type of plasma spray treatment that has been most used, which is elaborated with the ionized flame of a gas heated between 10000°C and 30000°C, and the particles are launched at high speed against the implant body. Upon contact, these particles cool and solidify. Plasma spray is used to apply and incorporate Ti (titanium) and HA (hydroxyapatite) onto the implant surface [14].
Titanium plasma spray is formed by coating the implant with ionized gases by thermal spraying with titanium plasma spray. In this method, the ionized flame of a gas is launched against the implant wall at an elevated temperature between 10000°C and 30000°C. With this change, there is an acceleration of blood absorption, due to the effect on the wettability of this surface, there is an increase in the surface contact area, promoting better osseointegration [14, 15]. The titanium particle is fused on the surface, forming a ~ 50 μm thick layer, with the resulting coating being between 10 μm and 40 μm, increasing the surface of the implant. Herrero-Climent et al. [16], carried out a comparative study between plasma spray titanium (TPS) and titanium oxide blasted surfaces, demonstrating that the TPS surface presented a unique pattern of bone matrix formation when compared to the titanium oxide blasted surface.
Meanwhile, the treatment for coating with apatite nucleation occurs through three stages: alkaline treatment, thermal treatment, and immersion in a synthetic solution equivalent to blood plasma. This layer is obtained by spraying the plasma spray of hydroxyapatite onto the implant surface [15]. Roughness depends on the size of the particles, their adhesion, the speed and distance at which they were launched against the implant [14]. According to De Groot et al. [17], hydroxyapatite plasma spray implants have already been studied and considered to have a high potential for osseointegration. Other authors showed that titanium implants coated with plasma spray of hydroxyapatite had greater amounts of bone at the bone/implant interface when compared to implants with smooth surface [18, 19].
In this type of surface treatment, the implant’s surface is modified by irradiation by means of laser beams, producing erosions and a rough surface. It is considered a clean treatment as it does not interact with any external material during the surface modification process, in which the laser beam acts as a physical means in the treatment of this surface [15]. Studies have shown that this method can stimulate adequate osseointegration to implants [20, 21]. In addition, laser treatment has the advantage that oriented, regular micro-grooves with different depths can be created at defined points on the surface [14]. Roughness sizes depend on the pulse intensity of the emitting source [9]. This type of surface has been extensively studied by Ricci et al. [22], showing that micro sulci can modulate cell organization and, consequently, positively influence the osseointegration process.
This type of treatment for the implant surface is blasting with microparticles of some abrasive material (e.g., aluminum oxide or titanium oxide), which promotes irregular surface depressions. Ideally, there should be no adhesion of particles to the implant (residues), which should be removed during the cleaning and decontamination processes. Obviously, the roughness caused depends on the size of the microparticles used, the time and pressure used in the process [9, 14, 15, 21]. In Figure 4 it is possible to observe the result of the treatment of a surface using only the sandblasting with aluminum oxide particles. However, the roughness produced has sharp edges and several non-uniform irregularities, which can make contact and cell organization difficult and, consequently, have an opposite effect to what is expected for an adequate osseointegration. Currently, this type of isolated treatment is little used by the industry.
SEM images of a surface treated by sandblasting with aluminum oxide, where we can observe in higher magnifications the presence of sharp edges and other deformations resulting from this surface treatment process.
Moreover, SEM (scanning electron microscopy) analysis of implants subjected to microparticle blasting, in this case aluminum oxide (Al2O3), show residues from the manufacturing process that can contaminate the implant surface (Figure 5), which would be harmful to osseointegration, as they would compete with calcium for bone formation. On the other hand, the use of titanium oxide in place of alumina can be an alternative to avoid these undesirable effects on the implant surface [23, 24, 25].
SEM image showing some locations, among several in the same sample, with the presence of residual microparticles on a blast-treated surface. This surface continued to show the presence of residues even after the washing and decontamination process.
In this sense, Gehrke and Collaborators, comparing implants blasted with aluminum oxide and titanium oxide, demonstrated that the residual particles from blasting can interfere in the osseointegration process in these places where they are present [23]. Moreover, in other studies using in vitro and in vivo tests, were demonstrated an excellent biologic response of the surfaces treated by sandblasting with microparticles of titanium oxide [24], with minimal risk of contamination by the residual debris from the blasting procedure [25].
As described above, the sandblasting process, which can be done by different particles (e.g., aluminum oxide or titanium oxide) and different sizes (150–500 μm), creates deep, amorphous roughness and can leave sharp edges sharp on the surface of the implants. Therefore, acid etching was used after the blasting process, leaving a much more regular surface, and eliminating (rounding) the peaks left by the first process. This union between the 2 types of treatment was called and patented as SLA surface (Sandblasted, large grit, acid-etched implant surface) by the Straumann Company. For the treatment of SLA Straumann surface implants, blasting with coarse-grained aluminum oxide (250–500 μm) is initially performed, producing macro-roughness in the implant, followed by an acid etching (HCl/H2SO4), which is responsible for the microroughness on this surface [6]. However, this treatment model is used by several companies, with variation both in the blasting process and in the acid etching process.
In this sense, comparing 2 different models of implant surface blasting with aluminum oxide and titanium oxide and subsequent etching by different acids in scanning microscopy images, we can observe that the texture of the surfaces has a different morphology between them, as shown in images in Figure 6.
Images obtained by SEM at 100x magnification, showing 2 different models of implant surface sandblasting: (a) with aluminum oxide and (b) with titanium oxide. Both received further conditioning by different acids. We can observe that the surface texture has a different morphology between them.
To accelerate and improve the osseointegration process of this type of SLA surface, the processing means were modified, being made under nitrogen atmosphere and later stored in isotonic NaCl (sodium chloride), this surface being called SLActive. Thus, these implants could provide a more active osseointegration process than other implants [26] and, consequently, could be loaded with a reduced waiting time. In this new technique, the surface is hydroxylated, and this chemical change improves the surface structures, which are ideal for protein adsorption and to promote immediate implant intent into bone tissue. The SLActive surface was developed to optimize implant stability in less time and reduce treatment risks in the early stages [27]. Rupp et al. [27], demonstrated that the SLActive and SLA surfaces did not show apparent differences when both had the same topography, however, statistically significant differences were observed within two or four weeks of BIC repair (bone/implant contact). This demonstrates that the changes were not a consequence of the topography, but that they were probably due to changes in the chemical structures made on the surface. Oates et al. [28] demonstrated that accelerated bone formation can influence implant stability. Also, in that same study, the authors observed that the transition time from primary stability to secondary stability was two weeks for SLActive surface and four weeks for SLA.
The surface treatment by conditioning through acids is made by immersing the implant in an acidic substance, which causes erosion on this surface. Acid concentration, time and temperature are determining factors of the surface microstructure. On the smooth surface, the most used process is the double acid attack, carried out with sulfuric acid and hydrochloride [29]. This surface treatment process provides a very uniform morphology, however, with less depth of ripple compared to SLA-type surfaces. An advantage of this type of treatment is that it supposedly does not leave residues of contaminants in your process. In Figure 7 we can see an implant surface treated by acid etching.
SEM images at different magnifications of an acid-etched implant surface.
In the case of nanotextured surfaces, treated with anodizing, they receive an extra layer of titanium dioxide. Thus, these surfaces are obtained using the implant as an anode, activating ions, and applying an electrical potential, which generates charge and ion transfer reactions. Controlled, the electric field will guide the oxidation process that takes place on the implant and results in an increase in the thickness of the titanium oxide (TiO2) layer. With the increase of this titanium oxide layer and the addition of other elements, such as phosphate (PO4), there is a potentialization of osseointegration [9].
Corrosion resistance and biocompatibility are related to the presence of a non-reactive oxide layer, which prevents the formation of fibrous tissue around the implant and creates a direct contact with the bone tissue [21, 27]. Implants with this surface treatment are less dependent on chemical composition, as the resulting process is defined by a complementary increase in bone-implant contact [30]. This type of surface treatment has become well known in the implantology field for being used in implants from the Nobel Biocare company (Sweden). Figure 8 shows images obtained by SEM of the surface of an anodized implant.
SEM images with different magnifications of an implant surface treated by the anodized method.
Abe et al. [31], presented a procedure that allowed to cover the implant surface with a uniform layer of HA similar to the biological layer, up to 15 μm thick, called the biomimetic method. This type of surface treatment consists of the heterogeneous precipitation of calcium phosphate under physiological conditions of temperature and pH on the dental implant, using a solution of ions similar to blood plasma with a view to deposition of the apatite layer. Once the molecules are integrated into the material structure, they are gradually released, thus being able to increase bone conductivity and enhance bone formation around the implant [32]. Currently, calcium phosphate is one of the main biomaterials for bone tissue replacement and regeneration, as its main characteristics are similar to the mineral phase of bone tissue, excellent biocompatibility, bioactivity, absence of toxicity, degradation rates variables and osteoconductivity [32]. Another advantage of this surface treatment is that biologically active molecules, such as osteogenic agents, can be precipitated as inorganic components to form a matrix with both osteoinductive (growth factors) and osteoconductive (calcium phosphate layer) properties [21, 27]. Figure 9 shows SEM images of an implant surface treated by the biomimetic method.
SEM images at different magnifications showing an implant surface treated by the biomimetic method.
Studies on this type of surface have shown greater contact between bone and implant on surfaces with biomimetic calcium phosphate coatings than on untreated surfaces [21]. Huang et al. [33], investigated the effects of chemical and nanotopographic modifications in the initial stages of osseointegration, and the results showed a greater removal torque and greater bone apposition for implants with chemical nanotopographic modifications. Recently, we presented in a study of adhesion, cell growth and in vitro mineralization using a surface with deposition of hydroxyapatite nanoparticles showed a superior result to the control group [23]. Furthermore, our group studied the deposition of calcium–magnesium on the surface of implants, where an acceleration and improvement in the osseointegration of implants inserted in rabbit tibiae was observed histomorphometrically, compared to implants with surface treated by blasting with titanium oxide and conditioning acid.
In conclusion, we can say that the main results of surface treatments with the aim of improving osseointegration were to accelerate the osseointegration time, allowing the anticipated loading of implants. On the other hand, osseointegration occurs on the surfaces of dental implants, regardless of whether these are treated or not. Surface treatments improve the result of osseointegration, especially in the initial stages, benefiting a bone apposition with qualitative and quantitative density. Despite the results presented, the dental literature is not unanimous as to the best type of surface treatment.
Bone density and quality, surgical technique and implant body geometry are factors to be considered to obtain a shorter period of osseointegration, thus enabling a reduction in treatment time [34]. The relationship between these factors will determine the initial stability of the implant, defined as the absence of movement after its surgical insertion [35, 36, 37, 38]. According to some studies [34, 39, 40], the success of implants is dependent on the initial stability achieved, as this is a prerequisite for bone cell differentiation and osseointegration [41]. The shape of the implant has been one of the most contested variables among engineers and researchers, as it can directly influence the biomechanics of the implant inserted into bone tissue [42].
Regarding the implant body shapes most frequently found on the world market, we have cylindrical, semi-tapered and tapered implants, as shown schematically in Figure 10. Currently, most implant manufacturing companies use the last two implant designs mentioned above (semi-tapered or tapered). Initially, tapered implant designs were introduced in implant dentistry with the main advantage of producing better initial stability compared to cylindrical implants. Later, several studies were developed and published comparing the tapered with the cylindrical implant designs [43, 44, 45]. Recently, new discoveries about the advantages of these designs were observed, such as and, mainly, the lesser surgical trauma during the drilling procedures and insertion of these implants in the bone tissue [46].
Representative images of 3 implant designs: (a) cylindrical implant, (b) semi-tapered implant and (c) tapered implant.
Other authors have shown that the use of implants with a conical design can increase stability in low-density bone, since results demonstrated greater contact osteogenesis with this type of design [45]. However, the difference in this stability between implants with different designs has not been sufficiently investigated, with disagreements about the fact that the tapered implant shows higher values of initial stability when compared to the cylindrical implant [47] or not cylindrical [48].
For years, companies have sought to commercialize the tapered shape in order to combine the advantages of the two designs, considering that a tapered implant creates a basis for adequate primary stability, by allowing the gradual expansion of thin bone crests and determining a minimum of possible stress at the interface with the surrounding bone [49]. In addition, tapered implants can be used in different clinical situations, being installed with less damage to the bone bed, but their installation in the lower arch has not been widespread, as it is strongly recommended for areas with low density bone or bone beds after dental extractions [50].
During the last decades, different implant macrogeometries have been proposed and marketed, with variation in different points, such as body design, cervical and apical design, threads design, among others. As for the thread design, these can be found with square, V-shaped, trapezoidal and inverted trapezoidal shapes [45]. Figure 11 demonstrates different implant coil designs presented and marketed by different implant companies.
Images of different designs of implant threads produced and marketed.
For some authors, implants with narrow pattern threads increase the surface area, leading to a more favorable stress distribution, and achieving higher primary stability values [51, 52]. In addition, stresses are more sensitive to thread pitch in cancellous bone than in cortical bone [53]. However, considering that the ideal implant should provide a balance between compression and traction forces, minimizing the generation of shear force, the square shape was designed to reduce such force at the bone-interface. Implant and increase the stability of the implant [53]. Thread depth, thickness, angle, end and helical angle are some of the various geometric patterns that determine the functional surface of the thread and affect the distribution of biomechanical loads on implants [7].
Transforming shear forces into resistance forces at the bone interface is the proposal to incorporate threads into the body of implants [54, 55]. This is why most implants are currently threaded, as non-threaded implants essentially result in shear forces at the bone-implant interface [26, 56, 57, 58]. Kohn et al. [59], demonstrated that the tension is more concentrated in the area of contact between the bone and the crest of the thread and that this tension decreases from the crest to its most basal portion. It has been proposed that threads, due to their shapes, would generate heterogeneous stress fields within the “physiological overload zone”, thus promoting new bone formation [60], which would justify the formation of bone in intimate contact with the crest of the threads. However, it should be noted that the threads have different shapes, therefore different distributions of forces and biological responses, which will be discussed below.
The functional surface area per unit of implant length can be modified by varying 3 parameters of the thread geometry: pitch, shape and depth [61]. The shape of the thread is a very important feature of its general geometry. The shape of the thread can change the direction of occlusal loading of the prosthesis to different directions in the bone. Under axial loads, a triangular thread is comparable to a trapezoidal thread when the face angles are similar, which are usually 30 degrees [62]. It has been suggested that a square thread design reduces the shear force component, transferring the axial force that falls on the prosthesis to the implant body in a more axial fashion, favoring bone compression [63]. This would be particularly important for the bone crest region, where, according to Lum [64], most occlusal forces are distributed. Therefore, implant design considerations that reduce the development of shear forces at the bone-implant interface can improve long-term success, particularly in low-density bones [65]. The original Bränemark implant, introduced in 1965, had triangular threads, to be installed in place with threaded osteotomy16. The initial design has been modified over the years to allow for a simpler and more efficient installation, as well as a better distribution of loads. Albrektsson et al. [66], recommend that the top of the threads be rounded to relieve stress concentration.
The thread pitch is defined as the number of threads per unit of length in the same axial plane and on the same side of the axis of the implant body [61]. The smaller the pitch, the greater the number of threads in the implant body, and therefore the greater surface area. So, if the magnitude of force is increased or bone density is reduced, the thread pitch can be reduced to increase the functional surface area, thus improving the stress distribution. Ease of surgical insertion is also associated with the number of threads. The smaller the number of threads, the easier the implant insertion. In denser bones, however, a smaller number of threads is more favorable, since the hard bone offers greater resistance during insertion of a threaded implant [61]. Another important factor to be discussed is the difference between the final milling dimension proposed by the manufacturer and the implant body. Usually, the dimension of the last reamer used for the osteotomy corresponds to the diameter of the implant body. Thus, the deeper the turns, the greater this difference will be, causing a greater insertion of the implant (threads) into the bone tissue. Figure 12 schematically shows the difference between the cutter and the implant in two different thread models.
Schematic images of the difference between the final reamer used for the osteotomy of each implant model and the thread depth that would be introduced into the bone tissue.
Other concept is the “double-thread” and “triple-thread” implants has been recently introduced [63]. These implants have been associated with faster threading in the surgical alveolus and with an increase in primary stability, as they require a higher insertion torque, and are indicated for cases of low density bone [67]. However, the number of threads, their depth and the total surface area are exactly the same regardless of the number of threads, whether single, double or triple.
Instead of using a single instrument to make a 0.6 mm thread for each turn on the device, 2 or 3 instruments make 2 or 3 turns at the same time. These 2 or 3 devices are independent, starting 180° apart from each other and are also 0.6 mm threaded apart. In other words, a single thread contours the implant body 0.6 mm apart and the double thread 1.2 mm apart, on the same surface area. This technique allows installation of the implant in half the time [63].
The triangular thread shape has a 10 times greater shear over the bone than a square thread and is similar to the trapezoidal thread [61]. Square threads have an optimized surface area, which is great for transmitting intrusive and compressive loads, resulting in less bone tension. Trapezoidal threads are optimized to resist tensile loads [68]. Implants with reverse trapezoidal threads have fewer and shallower threads [63].
Another advance in the shape of threads has been the introduction of round shapes, which are said to induce osseocompression [63]. A round-shaped design has shown, in histological observations in animals, the formation of lamellar bone by osseocompression [69]. This allows the bone to be shaped and compacted circumferentially.
Thread depth refers to the distance between the largest and smallest diameter of the thread. Traditional implants offer a uniform thread depth, however this can be varied along the length of the implant in order to provide a functional surface area in the most intense stress regions (such as the alveolar bone crest region) [61]. Regarding the quality and percentage of osseointegration, Steigenga et al. [70], analyzed the effect of 3 types of threads (triangular, square and trapezoidal) through histomorphometric and reverse torque analyses. They found a significantly higher reverse feel and percentage of bone-to-implant contact for implants with square threads. No significant difference was found between the tests for implants with triangular and trapezoidal threads, corroborating the results of other studies with different methodologies [61, 62, 70]. It should be considered that the different shapes of the threads cause different distributions of forces and biological responses [56, 57, 59, 60, 62, 71, 72].
Modifications in the morphology and roughness of the implant surface were initially attempted not only to accelerate the host’s response to the implant, but also to increase the level of mechanical locking between the bone and the implant surface, thus improving initial stability and subsequent dissipation loads during the functional requirements of the system [72]. Numerous studies based on histological tests have shown that surface texturing, created by different processes, leads to greater contact between bone and implant compared to the machined surface [6, 10, 73], which is a desirable answer to improve the overall biomechanics of the system, as show in the Section 2.1 of the present chapter. However, recently, new implant designs have been developed that seek, mainly, to accelerate and improve the quality of osseointegration through the concept of decreasing bone tissue compression during implant installation.
In most implant systems, osteotomy is recommended using the last drill with a diameter slightly smaller than the diameter of the implant, so that it can be inserted with a high degree of torque. Obviously, the more undersized the site that will receive the implant, the greater the insertion torque. However, studies have shown that high levels of torque can cause high compression of bone tissue, which can lead to extensive bone remodeling over time [74]. Several other studies have shown that, depending on the implant insertion torque and the physiological tolerance limit, microfractures or compression osteonecrosis may occur [75, 76, 77].
In this sense, it was recently proposed in some studies that approximating the osteotomy diameter with the diameter of the implant that will be implanted can facilitate and improve osseointegration [77, 78]. This fact was demonstrated in other animal studies, in which implants that were installed with high torque had a certain amount of necrotic bone inside the threads of the implants, while in samples where a perforation with a diameter closer to the diameter of the implant, greater new bone formation [78]. In this case, the free space created within the implant threads, resulting from the diameter-drill-implant relationship, was called healing chambers (Figure 13).
Schematic images of the relationship between the osteotomy (blue lines) and the implant diameter inserted. In the left image the regular osteotomy and in the right image the oversized osteotomy generating the healing chambers.
In order to reduce the compression during insertion of the implant into bone tissue, two new implant models were recently launched on the world market, the BLX Straumann model (Basel, Switzerland) and the Maestro Implacil De Bortoli model (São Paulo, Brazil), that are presented in the Figure 14.
Image of both implant models recently launched on the world market that were developed to reduce bone compression during the insertion process.
The first model (BLX Straumann implant) has technical recommendations to avoid bone compression, that during the execution of movements for insertion, whenever the torque of 35 N is reached, the professional must perform anti-rotational turns movements (removal torque) and then go back to inserting, repeating this movement whenever necessary. Thus, with a torque value below 35 N, bone tissue compression would be low, facilitating the osseointegration process. While in the second model described (Maestro Implacil implant), healing chambers were created in the implant body, which consist of small circular cavities 0.2 mm deep by 0.5 mm in diameter, as shown in Figure 15. With the presence of these healing chambers, bone tissue decompression occurs automatically during its insertion, not requiring any additional maneuvers. As reported in our studies of this new implant macrogeometries, this implant model has a reduced insertion torque compared to the model that does not feature healing chambers but did not show lower initial stability values measured by resonance frequency [12, 79, 80, 81].
SEM image of the healing chambers that were created in the implant body, which consist of small circular cavities 0.2 mm deep by 0.5 mm in diameter.
Within the exposed in this chapter, we can conclude that there is no implant with ideal characteristics, whether from a nano-, micro- or macrogeometric point of view. However, great advances in the knowledge of biological processes involving implant osseointegration have been discovered in recent years, which allowed a better understanding of these events. Undoubtedly, the new macrogeometric designs, based on the biological concept of minimizing surgical trauma, brought important advances in terms of accelerating the osseointegration process and, mainly, being able to benefit patients with systemic and/or local weaknesses that could negatively interfere in the process of implant osseointegration.
The authors declare no conflict of interest.
General requirements for Open Access to Horizon 2020 research project outputs are found within Guidelines on Open Access to Scientific Publication and Research Data in Horizon 2020. The guidelines, in their simplest form, state that if you are a Horizon 2020 recipient, you must ensure open access to your scientific publications by enabling them to be downloaded, printed and read online. Additionally, said publications must be peer reviewed.
',metaTitle:"Horizon 2020 Compliance",metaDescription:"General requirements for Open Access to Horizon 2020 research project outputs are found within Guidelines on Open Access to Scientific Publication and Research Data in Horizon 2020. The guidelines, in their simplest form, state that if you are a Horizon 2020 recipient, you must ensure open access to your scientific publications by enabling them to be downloaded, printed and read online. Additionally, said publications must be peer reviewed. ",metaKeywords:null,canonicalURL:null,contentRaw:'[{"type":"htmlEditorComponent","content":"Publishing with IntechOpen means that your scientific publications already meet these basic requirements. It also means that through our utilization of open licensing, our publications are also able to be copied, shared, searched, linked, crawled, and mined for text and data, optimizing our authors' compliance as suggested by the European Commission.
\\n\\nMetadata for all publications is also automatically deposited in IntechOpen's OAI repository, making them available through the Open Access Infrastructure for Research in Europe's (OpenAIRE) search interface further establishing our compliance.
\\n\\nIn other words, publishing with IntechOpen guarantees compliance.
\\n\\nRead more about Open Access in Horizon 2020 here.
\\n\\nWhich scientific publication to choose?
\\n\\nWhen choosing a publication, Horizon 2020 grant recipients are encouraged to provide open access to various types of scientific publications including monographs, edited books and conference proceedings.
\\n\\nIntechOpen publishes all of the aforementioned formats in compliance with the requirements and criteria established by the European Commission for the Horizon 2020 Program.
\\n\\nAuthors requiring additional information are welcome to send their inquiries to funders@intechopen.com
\\n"}]'},components:[{type:"htmlEditorComponent",content:'Publishing with IntechOpen means that your scientific publications already meet these basic requirements. It also means that through our utilization of open licensing, our publications are also able to be copied, shared, searched, linked, crawled, and mined for text and data, optimizing our authors' compliance as suggested by the European Commission.
\n\nMetadata for all publications is also automatically deposited in IntechOpen's OAI repository, making them available through the Open Access Infrastructure for Research in Europe's (OpenAIRE) search interface further establishing our compliance.
\n\nIn other words, publishing with IntechOpen guarantees compliance.
\n\nRead more about Open Access in Horizon 2020 here.
\n\nWhich scientific publication to choose?
\n\nWhen choosing a publication, Horizon 2020 grant recipients are encouraged to provide open access to various types of scientific publications including monographs, edited books and conference proceedings.
\n\nIntechOpen publishes all of the aforementioned formats in compliance with the requirements and criteria established by the European Commission for the Horizon 2020 Program.
\n\nAuthors requiring additional information are welcome to send their inquiries to funders@intechopen.com
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6669},{group:"region",caption:"Middle and South America",value:2,count:5955},{group:"region",caption:"Africa",value:3,count:2458},{group:"region",caption:"Asia",value:4,count:12710},{group:"region",caption:"Australia and Oceania",value:5,count:1016},{group:"region",caption:"Europe",value:6,count:17715}],offset:12,limit:12,total:134176},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{topicId:"23"},books:[{type:"book",id:"11433",title:"Human Migration in the Last Three Centuries",subtitle:null,isOpenForSubmission:!0,hash:"9836df9e82aa9f82e3852a60204909a8",slug:null,bookSignature:"Dr. Ingrid Muenstermann",coverURL:"https://cdn.intechopen.com/books/images_new/11433.jpg",editedByType:null,editors:[{id:"77112",title:"Dr.",name:"Ingrid",surname:"Muenstermann",slug:"ingrid-muenstermann",fullName:"Ingrid Muenstermann"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11437",title:"Social Media - Risks and Opportunities",subtitle:null,isOpenForSubmission:!0,hash:"000e31f2e2f7295805e9a3864158ad63",slug:null,bookSignature:"Dr. Shafizan Mohamed and Dr. Shazleen Mohamed",coverURL:"https://cdn.intechopen.com/books/images_new/11437.jpg",editedByType:null,editors:[{id:"302450",title:"Associate Prof.",name:"Shafizan",surname:"Mohamed",slug:"shafizan-mohamed",fullName:"Shafizan Mohamed"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11438",title:"Fake News in the Era of Global Crises",subtitle:null,isOpenForSubmission:!0,hash:"5f61f975031e13ee705d8b5853f1aa58",slug:null,bookSignature:"Dr. David Eller",coverURL:"https://cdn.intechopen.com/books/images_new/11438.jpg",editedByType:null,editors:[{id:"476616",title:"Dr.",name:"Jack",surname:"Eller",slug:"jack-eller",fullName:"Jack Eller"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11473",title:"Social Inequality - Structure and Social Processes",subtitle:null,isOpenForSubmission:!0,hash:"cefab077e403fd1695fb2946e7914942",slug:null,bookSignature:"Ph.D. Yaroslava Robles-Bykbaev",coverURL:"https://cdn.intechopen.com/books/images_new/11473.jpg",editedByType:null,editors:[{id:"313341",title:"Ph.D.",name:"Yaroslava",surname:"Robles-Bykbaev",slug:"yaroslava-robles-bykbaev",fullName:"Yaroslava Robles-Bykbaev"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11474",title:"Quality of Life Interventions - Magnitude of Effect and Transferability",subtitle:null,isOpenForSubmission:!0,hash:"5a6bcdaf5ee144d043bcdab893ff9e1c",slug:null,bookSignature:"Ph.D. Sage Arbor",coverURL:"https://cdn.intechopen.com/books/images_new/11474.jpg",editedByType:null,editors:[{id:"245319",title:"Ph.D.",name:"Sage",surname:"Arbor",slug:"sage-arbor",fullName:"Sage Arbor"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11769",title:"Multiculturalism and Interculturalism",subtitle:null,isOpenForSubmission:!0,hash:"6c4bda24f278d74f943f2155f13f4d73",slug:null,bookSignature:"Dr. Muhammad Mohiuddin, Dr. Tareque Aziz and Dr. Sreenivasan Jayashree",coverURL:"https://cdn.intechopen.com/books/images_new/11769.jpg",editedByType:null,editors:[{id:"418514",title:"Dr.",name:"Muhammad",surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11770",title:"Feminism",subtitle:null,isOpenForSubmission:!0,hash:"008be465c708a6fde48c8468757a40af",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11770.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11773",title:"Archaeology - Challenges and Updates",subtitle:null,isOpenForSubmission:!0,hash:"17d91462fa926279f65164ac0d5641cd",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11773.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11779",title:"Non-government Organizations - New Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"c109a472a9e0ea8398ae95e2d21be039",slug:null,bookSignature:"Prof. Vito Bobek and Dr. Tatjana Horvat",coverURL:"https://cdn.intechopen.com/books/images_new/11779.jpg",editedByType:null,editors:[{id:"128342",title:"Prof.",name:"Vito",surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11780",title:"Volunteering",subtitle:null,isOpenForSubmission:!0,hash:"008a5fc8005ea6b9228cfe39f9521abe",slug:null,bookSignature:"Ph.D. Diann Kelly",coverURL:"https://cdn.intechopen.com/books/images_new/11780.jpg",editedByType:null,editors:[{id:"325207",title:"Ph.D.",name:"Diann",surname:"Kelly",slug:"diann-kelly",fullName:"Diann Kelly"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12115",title:"European Politics",subtitle:null,isOpenForSubmission:!0,hash:"274a7fe06bb1c3cf128bf7ad081c7c12",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12115.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12116",title:"Youth and Youth Work",subtitle:null,isOpenForSubmission:!0,hash:"5fcd245b25b23db90b3fd0430d61e168",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12116.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:39},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:13},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:24},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:16},{group:"topic",caption:"Engineering",value:11,count:66},{group:"topic",caption:"Environmental Sciences",value:12,count:10},{group:"topic",caption:"Immunology and Microbiology",value:13,count:16},{group:"topic",caption:"Materials Science",value:14,count:25},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:120},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:6},{group:"topic",caption:"Neuroscience",value:18,count:4},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:9},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:34},popularBooks:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4430},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11043",title:"Endometriosis",subtitle:"Recent Advances, New Perspectives and Treatments",isOpenForSubmission:!1,hash:"7baf1c70b11d41400bb9302ae9411ca4",slug:"endometriosis-recent-advances-new-perspectives-and-treatments",bookSignature:"Giovana Ap. Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11043.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"185930",title:"Associate Prof.",name:"Giovana",middleName:null,surname:"Gonçalves",slug:"giovana-goncalves",fullName:"Giovana Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!1,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:"campylobacter",bookSignature:"Guillermo Tellez-Isaias and Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",isOpenForSubmission:!1,hash:"f197f6062c1574a9a90e50a369271bcf",slug:"starch-evolution-and-recent-advances",bookSignature:"Martins Ochubiojo Emeje",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11083",title:"Hazardous Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"d553bd4f6f1c4b115ca69bd19faac7dc",slug:"hazardous-waste-management",bookSignature:"Rajesh Banu Jeyakumar, Kavitha Sankarapandian and Yukesh Kannah Ravi",coverURL:"https://cdn.intechopen.com/books/images_new/11083.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10848",title:"Tribology of Machine Elements",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"3c4ca4c4692ca8d4fa749b4ae81ec1fa",slug:"tribology-of-machine-elements-fundamentals-and-applications",bookSignature:"Giuseppe Pintaude, Tiago Cousseau and Anna Rudawska",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"18347",title:"Prof.",name:"Giuseppe",middleName:null,surname:"Pintaude",slug:"giuseppe-pintaude",fullName:"Giuseppe Pintaude"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10856",title:"Crude Oil",subtitle:"New Technologies and Recent Approaches",isOpenForSubmission:!1,hash:"8d0a7ca35b3de95b295dc4eab39a087e",slug:"crude-oil-new-technologies-and-recent-approaches",bookSignature:"Manar Elsayed Abdel-Raouf and Mohamed Hasan El-Keshawy",coverURL:"https://cdn.intechopen.com/books/images_new/10856.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"102626",title:"Prof.",name:"Manar",middleName:null,surname:"Elsayed Abdel-Raouf",slug:"manar-elsayed-abdel-raouf",fullName:"Manar Elsayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9625",title:"Spinocerebellar Ataxia",subtitle:"Concepts, Particularities and Generalities",isOpenForSubmission:!1,hash:"365a7025fd46eb45de2549bdd9d50b98",slug:"spinocerebellar-ataxia-concepts-particularities-and-generalities",bookSignature:"Patricia Bozzetto Ambrosi",coverURL:"https://cdn.intechopen.com/books/images_new/9625.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"221787",title:"Dr.",name:"Patricia",middleName:null,surname:"Bozzetto Ambrosi",slug:"patricia-bozzetto-ambrosi",fullName:"Patricia Bozzetto Ambrosi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10905",title:"Plant Defense Mechanisms",subtitle:null,isOpenForSubmission:!1,hash:"84ad5b27dde5f01dc76087d0fd6fa834",slug:"plant-defense-mechanisms",bookSignature:"Josphert Ngui Kimatu",coverURL:"https://cdn.intechopen.com/books/images_new/10905.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"224171",title:"Prof.",name:"Josphert N.",middleName:null,surname:"Kimatu",slug:"josphert-n.-kimatu",fullName:"Josphert N. Kimatu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10686",title:"Natural Gas",subtitle:"New Perspectives and Future Developments",isOpenForSubmission:!1,hash:"581763788a6a59e653a9d1d9b5a42d79",slug:"natural-gas-new-perspectives-and-future-developments",bookSignature:"Maryam Takht Ravanchi",coverURL:"https://cdn.intechopen.com/books/images_new/10686.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"2416",title:"Dr.",name:"Maryam",middleName:null,surname:"Takht Ravanchi",slug:"maryam-takht-ravanchi",fullName:"Maryam Takht Ravanchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10988",title:"Railway Transport Planning and Manageme",subtitle:null,isOpenForSubmission:!1,hash:"5cb54cc53caedad9ec78372563c82e2c",slug:"railway-transport-planning-and-management",bookSignature:"Stefano de Luca, Roberta Di Pace and Chiara Fiori",coverURL:"https://cdn.intechopen.com/books/images_new/10988.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"22",title:"Robotics",slug:"physical-sciences-engineering-and-technology-robotics",parent:{id:"1",title:"Physical Sciences, Engineering and Technology",slug:"physical-sciences-engineering-and-technology"},numberOfBooks:104,numberOfSeries:0,numberOfAuthorsAndEditors:1443,numberOfWosCitations:4568,numberOfCrossrefCitations:3782,numberOfDimensionsCitations:7114,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"22",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10655",title:"Motion Planning",subtitle:null,isOpenForSubmission:!1,hash:"bf915895c5372e30c213b65ad1a62322",slug:"motion-planning",bookSignature:"Edgar A. Martínez García",coverURL:"https://cdn.intechopen.com/books/images_new/10655.jpg",editedByType:"Edited by",editors:[{id:"84958",title:"Dr.",name:"Edgar A.",middleName:"Alonso",surname:"Martínez García",slug:"edgar-a.-martinez-garcia",fullName:"Edgar A. Martínez García"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10417",title:"Collaborative and Humanoid Robots",subtitle:null,isOpenForSubmission:!1,hash:"dd42dd44dc386e591e8ff04956762023",slug:"collaborative-and-humanoid-robots",bookSignature:"Jesús Hamilton Ortiz and Ramana Kumar Vinjamuri",coverURL:"https://cdn.intechopen.com/books/images_new/10417.jpg",editedByType:"Edited by",editors:[{id:"283288",title:"Dr.",name:"Jesus Hamilton",middleName:null,surname:"Ortiz",slug:"jesus-hamilton-ortiz",fullName:"Jesus Hamilton Ortiz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10616",title:"Single Port Gynecologic Laparoscopic and Robotic-Assisted Surgery",subtitle:null,isOpenForSubmission:!1,hash:"0eaecc6e8ea016f111026b607d1673f7",slug:"single-port-gynecologic-laparoscopic-and-robotic-assisted-surgery",bookSignature:"Greg Marchand",coverURL:"https://cdn.intechopen.com/books/images_new/10616.jpg",editedByType:"Edited by",editors:[{id:"322729",title:"M.D.",name:"Greg",middleName:null,surname:"Marchand",slug:"greg-marchand",fullName:"Greg Marchand"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9869",title:"Self-Driving Vehicles and Enabling Technologies",subtitle:null,isOpenForSubmission:!1,hash:"fd451ca2e4785ef098e04b7d695a18d9",slug:"self-driving-vehicles-and-enabling-technologies",bookSignature:"Marian Găiceanu",coverURL:"https://cdn.intechopen.com/books/images_new/9869.jpg",editedByType:"Edited by",editors:[{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10569",title:"Latest Developments in Medical Robotics Systems",subtitle:null,isOpenForSubmission:!1,hash:"b48d1b7672b3d7e9e59ddc7b86d9b930",slug:"latest-developments-in-medical-robotics-systems",bookSignature:"Serdar Küçük",coverURL:"https://cdn.intechopen.com/books/images_new/10569.jpg",editedByType:"Edited by",editors:[{id:"5424",title:"Dr.",name:"Serdar",middleName:null,surname:"Küçük",slug:"serdar-kucuk",fullName:"Serdar Küçük"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9902",title:"Service Robotics",subtitle:null,isOpenForSubmission:!1,hash:"9b42f533ea14906bcd1e07df74b33ac2",slug:"service-robotics",bookSignature:"Volkan Sezer, Sinan Öncü and Pınar Boyraz Baykas",coverURL:"https://cdn.intechopen.com/books/images_new/9902.jpg",editedByType:"Edited by",editors:[{id:"268170",title:"Dr.",name:"Volkan",middleName:null,surname:"Sezer",slug:"volkan-sezer",fullName:"Volkan Sezer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6864",title:"Autonomous Vehicles",subtitle:null,isOpenForSubmission:!1,hash:"c320902fc1cfc252c1db006b944996fb",slug:"autonomous-vehicles",bookSignature:"George Dekoulis",coverURL:"https://cdn.intechopen.com/books/images_new/6864.jpg",editedByType:"Edited by",editors:[{id:"9833",title:"Prof.",name:"George",middleName:null,surname:"Dekoulis",slug:"george-dekoulis",fullName:"George Dekoulis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8883",title:"Autonomous Vehicle and Smart Traffic",subtitle:null,isOpenForSubmission:!1,hash:"841c82c0bf27716a7c800bc1180ad5de",slug:"autonomous-vehicle-and-smart-traffic",bookSignature:"Sezgin Ersoy and Tayyab Waqar",coverURL:"https://cdn.intechopen.com/books/images_new/8883.jpg",editedByType:"Edited by",editors:[{id:"156004",title:"Associate Prof.",name:"Sezgin",middleName:null,surname:"Ersoy",slug:"sezgin-ersoy",fullName:"Sezgin Ersoy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8872",title:"Multi Agent Systems",subtitle:"Strategies and Applications",isOpenForSubmission:!1,hash:"6b0454f8f575d5d65603f329af59c80b",slug:"multi-agent-systems-strategies-and-applications",bookSignature:"Ricardo López - Ruiz",coverURL:"https://cdn.intechopen.com/books/images_new/8872.jpg",editedByType:"Edited by",editors:[{id:"9849",title:"Prof.",name:"Ricardo",middleName:null,surname:"López-Ruiz",slug:"ricardo-lopez-ruiz",fullName:"Ricardo López-Ruiz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7792",title:"Unmanned Robotic Systems and Applications",subtitle:null,isOpenForSubmission:!1,hash:"53805f091c3107536edd2579c9987649",slug:"unmanned-robotic-systems-and-applications",bookSignature:"Mahmut Reyhanoglu and Geert De Cubber",coverURL:"https://cdn.intechopen.com/books/images_new/7792.jpg",editedByType:"Edited by",editors:[{id:"15068",title:"Dr.",name:"Mahmut",middleName:null,surname:"Reyhanoglu",slug:"mahmut-reyhanoglu",fullName:"Mahmut Reyhanoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6865",title:"Becoming Human with Humanoid",subtitle:"From Physical Interaction to Social Intelligence",isOpenForSubmission:!1,hash:"e208316a62e4ab5b042486aea682ee18",slug:"becoming-human-with-humanoid-from-physical-interaction-to-social-intelligence",bookSignature:"Ahmad Hoirul Basori, Ali Leylavi Shoushtari and Andon Venelinov Topalov",coverURL:"https://cdn.intechopen.com/books/images_new/6865.jpg",editedByType:"Edited by",editors:[{id:"13394",title:"Prof.",name:"Ahmad Hoirul",middleName:null,surname:"Basori",slug:"ahmad-hoirul-basori",fullName:"Ahmad Hoirul Basori"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7779",title:"Path Planning for Autonomous Vehicle",subtitle:"Ensuring Reliable Driverless Navigation and Control Maneuver",isOpenForSubmission:!1,hash:"91196f0aadb70bd5cecac290401d614f",slug:"path-planning-for-autonomous-vehicles-ensuring-reliable-driverless-navigation-and-control-maneuver",bookSignature:"Umar Zakir Abdul Hamid, Volkan Sezer, Bin Li, Yanjun Huang and Muhammad Aizzat Zakaria",coverURL:"https://cdn.intechopen.com/books/images_new/7779.jpg",editedByType:"Edited by",editors:[{id:"268173",title:"Dr.",name:"Umar Zakir Abdul",middleName:null,surname:"Hamid",slug:"umar-zakir-abdul-hamid",fullName:"Umar Zakir Abdul Hamid"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:104,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"10088",doi:"10.5772/8835",title:"Intention-Based Walking Support for Paraplegia Patients with Robot Suit HAL",slug:"intention-based-walking-support-for-paraplegia-patients-with-robot-suit-hal",totalDownloads:5448,totalCrossrefCites:15,totalDimensionsCites:158,abstract:null,book:{id:"3622",slug:"climbing-and-walking-robots",title:"Climbing and Walking Robots",fullTitle:"Climbing and Walking Robots"},signatures:"Kenta Suzuki, Gouji Mito, Hiroaki Kawamoto, Yasuhisa Hasegawa and Yoshiyuki Sankai",authors:null},{id:"240",doi:"10.5772/4876",title:"Geminoid: Teleoperated Android of an Existing Person",slug:"geminoid__teleoperated_android_of_an_existing_person",totalDownloads:4428,totalCrossrefCites:82,totalDimensionsCites:135,abstract:null,book:{id:"3373",slug:"humanoid_robots_new_developments",title:"Humanoid Robots",fullTitle:"Humanoid Robots: New Developments"},signatures:"Shuichi Nishio, Hiroshi Ishiguro and Norihiro Hagita",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"}]},{id:"172",doi:"10.5772/4808",title:"Limit Cycle Walking",slug:"limit_cycle_walking",totalDownloads:5105,totalCrossrefCites:12,totalDimensionsCites:99,abstract:null,book:{id:"3372",slug:"humanoid_robots_human_like_machines",title:"Humanoid Robots",fullTitle:"Humanoid Robots, Human-like Machines"},signatures:"Daan G.E. Hobbelen and Martijn Wisse",authors:null},{id:"6206",doi:"10.5772/6696",title:"Guidance Laws for Autonomous Underwater Vehicles",slug:"guidance_laws_for_autonomous_underwater_vehicles",totalDownloads:6710,totalCrossrefCites:40,totalDimensionsCites:83,abstract:null,book:{id:"3700",slug:"underwater_vehicles",title:"Underwater Vehicles",fullTitle:"Underwater Vehicles"},signatures:"Morten Breivik and Thor I. Fossen",authors:null},{id:"379",doi:"10.5772/5015",title:"Robot Kinematics: Forward and Inverse Kinematics",slug:"robot_kinematics__forward_and_inverse_kinematics",totalDownloads:51733,totalCrossrefCites:63,totalDimensionsCites:78,abstract:null,book:{id:"6110",slug:"industrial_robotics_theory_modelling_and_control",title:"Industrial Robotics",fullTitle:"Industrial Robotics: Theory, Modelling and Control"},signatures:"Serdar Kucuk and Zafer Bingul",authors:null}],mostDownloadedChaptersLast30Days:[{id:"379",title:"Robot Kinematics: Forward and Inverse Kinematics",slug:"robot_kinematics__forward_and_inverse_kinematics",totalDownloads:51733,totalCrossrefCites:63,totalDimensionsCites:78,abstract:null,book:{id:"6110",slug:"industrial_robotics_theory_modelling_and_control",title:"Industrial Robotics",fullTitle:"Industrial Robotics: Theory, Modelling and Control"},signatures:"Serdar Kucuk and Zafer Bingul",authors:null},{id:"56737",title:"UAV for Landmine Detection Using SDR-Based GPR Technology",slug:"uav-for-landmine-detection-using-sdr-based-gpr-technology",totalDownloads:3388,totalCrossrefCites:12,totalDimensionsCites:15,abstract:"This chapter presents an approach for explosive-landmine detection on-board an autonomous aerial drone. The chapter describes the design, implementation and integration of a ground penetrating radar (GPR) using a software defined radio (SDR) platform into the aerial drone. The chapter?s goal is first to tackle in detail the development of a custom-designed lightweight GPR by approaching interplay between hardware and software radio on an SDR platform. The SDR-based GPR system results on a much lighter sensing device compared against the conventional GPR systems found in the literature and with the capability of re-configuration in real-time for different landmines and terrains, with the capability of detecting landmines under terrains with different dielectric characteristics. Secondly, the chapter introduce the integration of the SDR-based GPR into an autonomous drone by describing the mechanical integration, communication system, the graphical user interface (GUI) together with the landmine detection and geo-mapping. This chapter approach completely the hardware and software implementation topics of the on-board GPR system given first a comprehensive background of the software-defined radar technology and second presenting the main features of the Tx and Rx modules. Additional details are presented related with the mechanical and functional integration of the GPR into the UAV system.",book:{id:"5905",slug:"robots-operating-in-hazardous-environments",title:"Robots Operating in Hazardous Environments",fullTitle:"Robots Operating in Hazardous Environments"},signatures:"Manuel Ricardo Pérez Cerquera, Julian David Colorado Montaño\nand Iván Mondragón",authors:[{id:"177422",title:"Dr.",name:"Julian",middleName:null,surname:"Colorado",slug:"julian-colorado",fullName:"Julian Colorado"},{id:"197884",title:"Prof.",name:"Ivan",middleName:null,surname:"Mondragon",slug:"ivan-mondragon",fullName:"Ivan Mondragon"},{id:"199958",title:"Prof.",name:"Manuel",middleName:null,surname:"Perez",slug:"manuel-perez",fullName:"Manuel Perez"}]},{id:"15855",title:"Kinematics of AdeptThree Robot Arm",slug:"kinematics-of-adeptthree-robot-arm",totalDownloads:14625,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"152",slug:"robot-arms",title:"Robot Arms",fullTitle:"Robot Arms"},signatures:"Adelhard Beni Rehiara",authors:[{id:"29287",title:"Dr.",name:"Adelhard",middleName:"Beni",surname:"Rehiara",slug:"adelhard-rehiara",fullName:"Adelhard Rehiara"}]},{id:"62978",title:"Intelligent Robotic Perception Systems",slug:"intelligent-robotic-perception-systems",totalDownloads:2395,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Robotic perception is related to many applications in robotics where sensory data and artificial intelligence/machine learning (AI/ML) techniques are involved. Examples of such applications are object detection, environment representation, scene understanding, human/pedestrian detection, activity recognition, semantic place classification, object modeling, among others. Robotic perception, in the scope of this chapter, encompasses the ML algorithms and techniques that empower robots to learn from sensory data and, based on learned models, to react and take decisions accordingly. The recent developments in machine learning, namely deep-learning approaches, are evident and, consequently, robotic perception systems are evolving in a way that new applications and tasks are becoming a reality. Recent advances in human-robot interaction, complex robotic tasks, intelligent reasoning, and decision-making are, at some extent, the results of the notorious evolution and success of ML algorithms. This chapter will cover recent and emerging topics and use-cases related to intelligent perception systems in robotics.",book:{id:"7227",slug:"applications-of-mobile-robots",title:"Applications of Mobile Robots",fullTitle:"Applications of Mobile Robots"},signatures:"Cristiano Premebida, Rares Ambrus and Zoltan-Csaba Marton",authors:[{id:"203409",title:"Ph.D.",name:"Cristiano",middleName:null,surname:"Premebida",slug:"cristiano-premebida",fullName:"Cristiano Premebida"},{id:"254880",title:"Dr.",name:"Rares",middleName:null,surname:"Ambrus",slug:"rares-ambrus",fullName:"Rares Ambrus"},{id:"254881",title:"Dr.",name:"Zoltan-Csaba",middleName:null,surname:"Marton",slug:"zoltan-csaba-marton",fullName:"Zoltan-Csaba Marton"}]},{id:"67705",title:"Advanced UAVs Nonlinear Control Systems and Applications",slug:"advanced-uavs-nonlinear-control-systems-and-applications",totalDownloads:1943,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Recent development of different control systems for UAVs has caught the attention of academic and industry, due to the wide range of their applications such as in surveillance, delivery, work assistant, and photography. In addition, arms, grippers, or tethers could be installed to UAVs so that they can assist in constructing, transporting, and carrying payloads. In this book chapter, the control laws of the attitude and position of a quadcopter UAV have been derived basically utilizing three methods including backstepping, sliding mode control, and feedback linearization incorporated with LQI optimal controller. The main contribution of this book chapter would be concluded in the strategy of deriving the control laws of the translational positions of a quadcopter UAV. The control laws for trajectory tracking using the proposed strategies have been validated by simulation using MATLAB®/Simulink and experimental results obtained from a quadcopter test bench. Simulation results show a comparison between the performances of each of the proposed techniques depending on the nonlinear model of the quadcopter system under investigation; the trajectory tracking has been achieved properly for different types of trajectories, i.e., spiral trajectory, in the presence of unknown disturbances. Moreover, the practical results coincided with the results of the simulation results.",book:{id:"7792",slug:"unmanned-robotic-systems-and-applications",title:"Unmanned Robotic Systems and Applications",fullTitle:"Unmanned Robotic Systems and Applications"},signatures:"Abdulkader Joukhadar, Mohammad Alchehabi and Adnan Jejeh",authors:null}],onlineFirstChaptersFilter:{topicId:"22",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82223",title:"Biomechanical Design Principles Underpinning Anthropomorphic Manipulators",slug:"biomechanical-design-principles-underpinning-anthropomorphic-manipulators",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105434",abstract:"The biomechanical design of an artificial anthropomorphic manipulator is the focus of many researchers in diverse fields. Current electromechanical artificial hands are either in the research stage, expensive, have patents, lack severely in function, and/or are driven by robotic/mechanical principles, which tend to ignore the biological requirements of such designs. In response to the challenges addressed above this chapter discusses the potential of current technology and methods used in design to bridge the chasm that exists between robot manipulators and the human hand. This chapter elucidates artificial anthropomorphic manipulator design by outlining biomechanical concepts that contribute to the function, esthetics and performance of artificial manipulators. This chapter addresses joint stabilization, tendon structures and tendon excursion in artificial anthropomorphic manipulators.",book:{id:"11455",title:"Recent Advances in Robot Manipulators",coverURL:"https://cdn.intechopen.com/books/images_new/11455.jpg"},signatures:"Mahonri William Owen and Chikit Au"},{id:"82056",title:"Learning Robotic Ultrasound Skills from Human Demonstrations",slug:"learning-robotic-ultrasound-skills-from-human-demonstrations",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.105069",abstract:"Robotic ultrasound system plays a vital role in assisting or even replacing sonographers in some cases. However, modeling and learning ultrasound skills from professional sonographers are still challenging tasks that hinder the development of ultrasound systems’ autonomy. To solve these problems, we propose a learning-based framework to acquire ultrasound scanning skills from human demonstrations1. First, ultrasound scanning skills are encapsulated into a high-dimensional multi-modal model, which takes ultrasound images, probe pose, and contact force into account. The model’s parameters can be learned from clinical ultrasound data demonstrated by professional sonographers. Second, the target function of autonomous ultrasound examinations is proposed, which can be solved roughly by the sampling-based strategy. The sonographers’ ultrasound skills can be represented by approximating the limit of the target function. Finally, the robustness of the proposed framework is validated with the experiments on ground-true data from sonographers.",book:{id:"10823",title:"Cognitive Robotics",coverURL:"https://cdn.intechopen.com/books/images_new/10823.jpg"},signatures:"Miao Li and Xutian Deng"},{id:"82057",title:"An Episodic-Procedural Semantic Memory Model for Continuous Topological Sensorimotor Map Building",slug:"an-episodic-procedural-semantic-memory-model-for-continuous-topological-sensorimotor-map-building",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.104818",abstract:"For humans to understand the world around them, learning and memory are two cognitive processes of the human brain that are deeply connected. Memory allows information to retain and forms an experiences reservoir. Computational models replicating those memory attributes can lead to the practical use of robots in everyday human living environments. However, constantly acquiring environmental information in real-world, dynamic environments has remained a challenge for many years. This article proposes an episodic-procedure semantic memory model to continuously generate topological sensorimotor maps for robot navigation. The proposed model consists of two memory networks: i) episodic-procedural memory network (EPMN) and ii) semantic memory network (SMN). The EPMN comprises an Incremental Recurrent Kernel Machines (I-RKM) that clusters incoming input vectors as nodes and learns the activation patterns of the nodes for spatiotemporal encoding. The SMN then takes neuronal activity trajectories from the EPMN and task-relevant signals to update the SMN and produce more compact representations of episodic experience. Thus, both memory networks prevent catastrophic forgetting by constantly generating nodes when the network meets new inputs or updating node weights when the incoming input is similar to previously learned knowledge. In addition, idle or outlier nodes will be removed to preserve memory space.",book:{id:"10823",title:"Cognitive Robotics",coverURL:"https://cdn.intechopen.com/books/images_new/10823.jpg"},signatures:"Wei Hong Chin, Naoyuki Kubota and Chu Kiong Loo"},{id:"81922",title:"Skill Acquisition for Resource-Constrained Mobile Robots through Continuous Exploration",slug:"skill-acquisition-for-resource-constrained-mobile-robots-through-continuous-exploration",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.104996",abstract:"We present a cognitive mobile robot that acquires knowledge, and autonomously learns higher-level abstract capabilities based on play instincts, inspired by human behavior. To this end, we (i) model skills, (ii) model the robot’s sensor and actuator space based on elementary physical properties, and (iii) propose algorithms inspired by humans’ play instincts that allow the robot to autonomously learn the skills based on its sensor and actuator capabilities. We model general knowledge in the form of competencies (skills) of the mobile robot based on kinematic properties using physical quantities. Thus, by design, our approach has the potential to cover very generic application domains. To connect desired skills to the primitive capabilities of the robot’s sensors and actuators, it playfully explores the effects of its actions on its sensory input, thus autonomously learning relations and dependencies and eventually the desired skill. KnowRob is used for knowledge representation and reasoning, and the robot’s operation is based on ROS. In the experiments, we use a millirobot, sized 2 cm2, equipped with two wheels, motion, and distance sensors. We show that our cognitive mobile robot can successfully and autonomously learn elementary motion skills based on a playful exploration of its wheels and sensors.",book:{id:"10823",title:"Cognitive Robotics",coverURL:"https://cdn.intechopen.com/books/images_new/10823.jpg"},signatures:"Markus D. Kobelrausch and Axel Jantsch"},{id:"81693",title:"The Neo-Mechanistic Model of Human Cognitive Computation and Its Major Challenges",slug:"the-neo-mechanistic-model-of-human-cognitive-computation-and-its-major-challenges",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.104995",abstract:"The neo-mechanistic theory of human cognition is currently one of the most accepted major theories in fields, such as cognitive science and cognitive neuroscience. This proposal offers an account of human cognitive computation, and it has been considered by its proponents as revolutionary and capable of integrating research concerning human cognition with new evidence provided by fields of biology and neuroscience. However, some complex cognitive capacities still present a challenge for explanations constructed by using this theoretical structure. In this chapter, I make a presentation of some of the central tenets of this framework and show in what dimensions it helps our understanding of human cognition concerning aspects of capacities, such as visual perception and memory consolidation. My central goal, however, is to show that to understand and explain some particular human cognitive capacities, such as self-consciousness and some conscious informal reasoning and decision making, the framework shows substantial limitations. I conclude the chapter by suggesting that to fully understand human cognition we will need much more than what the neo-mechanistic framework is actually able to provide.",book:{id:"10823",title:"Cognitive Robotics",coverURL:"https://cdn.intechopen.com/books/images_new/10823.jpg"},signatures:"Diego Azevedo Leite"},{id:"81719",title:"Service Robots in Healthcare Settings",slug:"service-robots-in-healthcare-settings",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.104640",abstract:"Robots will play a part in all aspects of healthcare. The presence of service robots in healthcare demands special attention, whether it is in the automation of menial labour, prescription distribution, or offering comfort. In this chapter, we examine the several applications of healthcare-oriented robots in the acute, ambulatory and at-home settings. We discuss the role of robotics in reducing environmental dangers, as well as at the patient’s bedside and in the operating room, in the acute setting. We examine how robotics can protect and scale up healthcare services in the ambulatory setting. Finally, in the at-home scenario, we look at how robots can be employed for both rural/remote healthcare delivery and home-based care. In addition to assessing the current state of robotics at the interface of healthcare delivery, we describe critical problems for the future where such technology will be ubiquitous. Patients, health care workers, institutions, insurance companies, and governments will realize that service robots will deliver significant benefits in the future in terms of leverage and cost savings, while maintaining or improving access, equity, and high-quality health care.",book:{id:"10657",title:"Advances in Service Robots",coverURL:"https://cdn.intechopen.com/books/images_new/10657.jpg"},signatures:"Rohit Singla and Christopher Nguan"}],onlineFirstChaptersTotal:7},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:317,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 28th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:9,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"13633",title:"Prof.",name:"Abdelhamid",middleName:null,surname:"Mellouk",slug:"abdelhamid-mellouk",fullName:"Abdelhamid Mellouk",profilePictureURL:"https://mts.intechopen.com/storage/users/13633/images/1567_n.jpg",institutionString:null,institution:{name:"Paris 12 Val de Marne University",institutionURL:null,country:{name:"France"}}},{id:"109268",title:"Dr.",name:"Ali",middleName:null,surname:"Al-Ataby",slug:"ali-al-ataby",fullName:"Ali Al-Ataby",profilePictureURL:"https://mts.intechopen.com/storage/users/109268/images/7410_n.jpg",institutionString:null,institution:{name:"University of Liverpool",institutionURL:null,country:{name:"United Kingdom"}}},{id:"3807",title:"Dr.",name:"Carmelo",middleName:"Jose Albanez",surname:"Bastos-Filho",slug:"carmelo-bastos-filho",fullName:"Carmelo Bastos-Filho",profilePictureURL:"https://mts.intechopen.com/storage/users/3807/images/624_n.jpg",institutionString:null,institution:{name:"Universidade de Pernambuco",institutionURL:null,country:{name:"Brazil"}}},{id:"38850",title:"Dr.",name:"Efren",middleName:null,surname:"Gorrostieta Hurtado",slug:"efren-gorrostieta-hurtado",fullName:"Efren Gorrostieta Hurtado",profilePictureURL:"https://mts.intechopen.com/storage/users/38850/images/system/38850.jpg",institutionString:null,institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},{id:"239041",title:"Prof.",name:"Yang",middleName:null,surname:"Yi",slug:"yang-yi",fullName:"Yang Yi",profilePictureURL:"https://mts.intechopen.com/storage/users/239041/images/system/239041.jpeg",institutionString:"Virginia Tech",institution:{name:"Virginia Tech",institutionURL:null,country:{name:"United States of America"}}}]},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"13818",title:"Dr.",name:"Asim",middleName:null,surname:"Bhatti",slug:"asim-bhatti",fullName:"Asim Bhatti",profilePictureURL:"https://mts.intechopen.com/storage/users/13818/images/system/13818.jpg",institutionString:null,institution:{name:"Deakin University",institutionURL:null,country:{name:"Australia"}}},{id:"151889",title:"Dr.",name:"Joao Luis Garcia",middleName:null,surname:"Rosa",slug:"joao-luis-garcia-rosa",fullName:"Joao Luis Garcia Rosa",profilePictureURL:"https://mts.intechopen.com/storage/users/151889/images/4861_n.jpg",institutionString:null,institution:{name:"University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",institutionURL:null,country:{name:"Turkey"}}}]},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"1177",title:"Prof.",name:"Antonio",middleName:"J. R.",surname:"Neves",slug:"antonio-neves",fullName:"Antonio Neves",profilePictureURL:"https://mts.intechopen.com/storage/users/1177/images/system/1177.jpg",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"220565",title:"Dr.",name:"Jucheng",middleName:null,surname:"Yang",slug:"jucheng-yang",fullName:"Jucheng Yang",profilePictureURL:"https://mts.intechopen.com/storage/users/220565/images/5988_n.jpg",institutionString:null,institution:{name:"Tianjin University of Technology",institutionURL:null,country:{name:"China"}}},{id:"29299",title:"Prof.",name:"Serestina",middleName:null,surname:"Viriri",slug:"serestina-viriri",fullName:"Serestina Viriri",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOalQAG/Profile_Picture_1620817405517",institutionString:null,institution:{name:"University of KwaZulu-Natal",institutionURL:null,country:{name:"South Africa"}}},{id:"315933",title:"Dr.",name:"Yalın",middleName:null,surname:"Baştanlar",slug:"yalin-bastanlar",fullName:"Yalın Baştanlar",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002qpr7hQAA/Profile_Picture_1621430127547",institutionString:null,institution:{name:"Izmir Institute of Technology",institutionURL:null,country:{name:"Turkey"}}}]},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"111683",title:"Prof.",name:"Elmer P.",middleName:"P.",surname:"Dadios",slug:"elmer-p.-dadios",fullName:"Elmer P. Dadios",profilePictureURL:"https://mts.intechopen.com/storage/users/111683/images/system/111683.jpg",institutionString:"De La Salle University",institution:{name:"De La Salle University",institutionURL:null,country:{name:"Philippines"}}},{id:"106873",title:"Prof.",name:"Hongwei",middleName:null,surname:"Ge",slug:"hongwei-ge",fullName:"Hongwei Ge",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Dalian University of Technology",institutionURL:null,country:{name:"China"}}},{id:"171056",title:"Dr.",name:"Sotirios",middleName:null,surname:"Goudos",slug:"sotirios-goudos",fullName:"Sotirios Goudos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9IuQAK/Profile_Picture_1622623673666",institutionString:null,institution:{name:"Aristotle University of Thessaloniki",institutionURL:null,country:{name:"Greece"}}},{id:"15895",title:"Assistant Prof.",name:"Takashi",middleName:null,surname:"Kuremoto",slug:"takashi-kuremoto",fullName:"Takashi Kuremoto",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLrqQAG/Profile_Picture_1625656196038",institutionString:null,institution:{name:"Nippon Institute of Technology",institutionURL:null,country:{name:"Japan"}}},{id:"125844",title:"Prof.",name:"Wellington",middleName:"Pinheiro Dos",surname:"Santos",slug:"wellington-santos",fullName:"Wellington Santos",profilePictureURL:"https://mts.intechopen.com/storage/users/125844/images/4878_n.jpg",institutionString:null,institution:{name:"Federal University of Pernambuco",institutionURL:null,country:{name:"Brazil"}}}]},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",slug:"ciza-thomas",fullName:"Ciza Thomas",profilePictureURL:"https://mts.intechopen.com/storage/users/43680/images/system/43680.jpeg",institutionString:null,institution:{name:"Government of Kerala",institutionURL:null,country:{name:"India"}}},{id:"16614",title:"Prof.",name:"Juan Ignacio",middleName:null,surname:"Guerrero Alonso",slug:"juan-ignacio-guerrero-alonso",fullName:"Juan Ignacio Guerrero Alonso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6HB8QAM/Profile_Picture_1627901127555",institutionString:null,institution:{name:"University of Seville",institutionURL:null,country:{name:"Spain"}}},{id:"3095",title:"Prof.",name:"Kenji",middleName:null,surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/3095/images/1592_n.jpg",institutionString:null,institution:{name:"University of Chicago",institutionURL:null,country:{name:"United States of America"}}},{id:"214067",title:"Dr.",name:"W. David",middleName:null,surname:"Pan",slug:"w.-david-pan",fullName:"W. David Pan",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSEI9QAO/Profile_Picture_1623656213532",institutionString:null,institution:{name:"University of Alabama in Huntsville",institutionURL:null,country:{name:"United States of America"}}},{id:"72920",title:"Prof.",name:"Yves",middleName:"Philippe",surname:"Rybarczyk",slug:"yves-rybarczyk",fullName:"Yves Rybarczyk",profilePictureURL:"https://mts.intechopen.com/storage/users/72920/images/system/72920.jpeg",institutionString:"Dalarna University, Faculty of Data and Information Sciences",institution:{name:"Dalarna University",institutionURL:null,country:{name:"Sweden"}}}]},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. He has served as guest editor for a number of special issues of peer-reviewed international journals.",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"275140",title:"Dr.",name:"Dinh Hoa",middleName:null,surname:"Nguyen",slug:"dinh-hoa-nguyen",fullName:"Dinh Hoa Nguyen",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRbnKQAS/Profile_Picture_1622204093453",institutionString:null,institution:{name:"Kyushu University",institutionURL:null,country:{name:"Japan"}}},{id:"20259",title:"Dr.",name:"Hongbin",middleName:null,surname:"Ma",slug:"hongbin-ma",fullName:"Hongbin Ma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRhDJQA0/Profile_Picture_2022-05-02T08:25:21.jpg",institutionString:null,institution:{name:"Beijing Institute of Technology",institutionURL:null,country:{name:"China"}}},{id:"28640",title:"Prof.",name:"Yasushi",middleName:null,surname:"Kambayashi",slug:"yasushi-kambayashi",fullName:"Yasushi Kambayashi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOQxQAO/Profile_Picture_1625660525470",institutionString:null,institution:{name:"Nippon Institute of Technology",institutionURL:null,country:{name:"Japan"}}}]}]},overviewPageOFChapters:{paginationCount:15,paginationItems:[{id:"82427",title:"Our Globalization Era among Success, Obstacles and Doubts",doi:"10.5772/intechopen.105545",signatures:"Arnaldo Canziani, Annalisa Baldissera and Ahmad Kahwaji",slug:"our-globalization-era-among-success-obstacles-and-doubts",totalDownloads:1,totalCrossrefCites:null,totalDimensionsCites:0,authors:null,book:{title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"82248",title:"Sustainability and Excellence: Pillars for Business Survival",doi:"10.5772/intechopen.105420",signatures:"Irina Severin, Maria Cristina Dijmarescu and Mihai Caramihai",slug:"sustainability-and-excellence-pillars-for-business-survival",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"82124",title:"Assessment of Diversity, Growth Characteristics and Aboveground Biomass of Tree Species in Selected Urban Green Areas of Osogbo, Osun State",doi:"10.5772/intechopen.104982",signatures:"Omolara Aremu, Olusola O. Adetoro and Olusegun Awotoye",slug:"assessment-of-diversity-growth-characteristics-and-aboveground-biomass-of-tree-species-in-selected-u",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",subseries:{id:"94",title:"Climate Change and Environmental Sustainability"}}},{id:"81975",title:"Self-Sustained Communities: Food Security in Times of Crisis",doi:"10.5772/intechopen.104425",signatures:"Kriengsak Chareonwongsak",slug:"self-sustained-communities-food-security-in-times-of-crisis",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}}]},overviewPagePublishedBooks:{paginationCount:0,paginationItems:[]},openForSubmissionBooks:{paginationCount:6,paginationItems:[{id:"11475",title:"Food Security Challenges and Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11475.jpg",hash:"090302a30e461cee643ec49675c811ec",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 5th 2022",isOpenForSubmission:!0,editors:[{id:"292145",title:"Dr.",name:"Muhammad",surname:"Haseeb Ahmad",slug:"muhammad-haseeb-ahmad",fullName:"Muhammad Haseeb Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11450",title:"Environmental Impacts of COVID-19 Pandemic on the World",coverURL:"https://cdn.intechopen.com/books/images_new/11450.jpg",hash:"a58c7b02d07903004be70f744f2e1835",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 10th 2022",isOpenForSubmission:!0,editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11477",title:"Public Economics - New Perspectives and Uncertainty",coverURL:"https://cdn.intechopen.com/books/images_new/11477.jpg",hash:"a8e6c515dc924146fbd2712eb4e7d118",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 27th 2022",isOpenForSubmission:!0,editors:[{id:"414400",title:"Dr.",name:"Habtamu",surname:"Alem",slug:"habtamu-alem",fullName:"Habtamu Alem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11457",title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",hash:"8df7150b01ae754024c65d1a62f190d9",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 1st 2022",isOpenForSubmission:!0,editors:[{id:"317087",title:"Dr.",name:"Pavel",surname:"Samec",slug:"pavel-samec",fullName:"Pavel Samec"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11474",title:"Quality of Life Interventions - Magnitude of Effect and Transferability",coverURL:"https://cdn.intechopen.com/books/images_new/11474.jpg",hash:"5a6bcdaf5ee144d043bcdab893ff9e1c",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 7th 2022",isOpenForSubmission:!0,editors:[{id:"245319",title:"Ph.D.",name:"Sage",surname:"Arbor",slug:"sage-arbor",fullName:"Sage Arbor"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11473",title:"Social Inequality - Structure and Social Processes",coverURL:"https://cdn.intechopen.com/books/images_new/11473.jpg",hash:"cefab077e403fd1695fb2946e7914942",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 13th 2022",isOpenForSubmission:!0,editors:[{id:"313341",title:"Ph.D.",name:"Yaroslava",surname:"Robles-Bykbaev",slug:"yaroslava-robles-bykbaev",fullName:"Yaroslava Robles-Bykbaev"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:5,paginationItems:[{id:"82394",title:"Learning by Doing Active Social Learning",doi:"10.5772/intechopen.105523",signatures:"Anat Raviv",slug:"learning-by-doing-active-social-learning",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"82310",title:"Knowledge of Intergenerational Contact to Combat Ageism towards Older People",doi:"10.5772/intechopen.105592",signatures:"Alice Nga Lai Kwong",slug:"knowledge-of-intergenerational-contact-to-combat-ageism-towards-older-people",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Social Aspects of Ageing - Selected Challenges, Analyses, and Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11479.jpg",subseries:{id:"90",title:"Human Development"}}},{id:"81993",title:"Emergent Chemistry: Using Visualizations to Develop Abstract Thinking and a Sense of Scale Within the Preschool Setting",doi:"10.5772/intechopen.105216",signatures:"Karina Adbo",slug:"emergent-chemistry-using-visualizations-to-develop-abstract-thinking-and-a-sense-of-scale-within-the",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"82252",title:"Early Childhood: Enriched Environments and Roles of Caring Adults",doi:"10.5772/intechopen.105157",signatures:"Analía Mignaton",slug:"early-childhood-enriched-environments-and-roles-of-caring-adults",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"81996",title:"Perspective Chapter: New Active Learning Models in Africa",doi:"10.5772/intechopen.105217",signatures:"Fred Awaah, Cosmas Lambini Kombat and Emmanuel Okyere Ekwam",slug:"perspective-chapter-new-active-learning-models-in-africa",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}}]},subseriesFiltersForOFChapters:[{caption:"Human Development",value:90,count:1,group:"subseries"},{caption:"Education",value:89,count:4,group:"subseries"}],publishedBooks:{paginationCount:32,paginationItems:[{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",slug:"starch-evolution-and-recent-advances",publishedDate:"June 28th 2022",editedByType:"Edited by",bookSignature:"Martins Ochubiojo Emeje",hash:"f197f6062c1574a9a90e50a369271bcf",volumeInSeries:33,fullTitle:"Starch - Evolution and Recent Advances",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",institutionURL:null,country:{name:"Nigeria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",slug:"essential-oils-advances-in-extractions-and-biological-applications",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",hash:"742e6cae3a35686f975edc8d7f9afa94",volumeInSeries:32,fullTitle:"Essential Oils - Advances in Extractions and Biological Applications",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira",profilePictureURL:"https://mts.intechopen.com/storage/users/195290/images/system/195290.png",institutionString:"Museu Paraense Emílio Goeldi",institution:{name:"Museu Paraense Emílio Goeldi",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10839",title:"Protein Detection",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",slug:"protein-detection",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Yusuf Tutar and Lütfi Tutar",hash:"2f1c0e4e0207fc45c936e7d22a5369c4",volumeInSeries:31,fullTitle:"Protein Detection",editors:[{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",institutionString:"University of Health Sciences",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10797",title:"Cell Culture",subtitle:"Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",slug:"cell-culture-advanced-technology-and-applications-in-medical-and-life-sciences",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Xianquan Zhan",hash:"2c628f4757f9639a4450728d839a7842",volumeInSeries:30,fullTitle:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",institutionURL:null,country:{name:"China"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10841",title:"Hydrolases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10841.jpg",slug:"hydrolases",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Sajjad Haider, Adnan Haider and Angel Catalá",hash:"4e868cde273d65a7ff54b1817d640629",volumeInSeries:29,fullTitle:"Hydrolases",editors:[{id:"110708",title:"Dr.",name:"Sajjad",middleName:null,surname:"Haider",slug:"sajjad-haider",fullName:"Sajjad Haider",profilePictureURL:"https://mts.intechopen.com/storage/users/110708/images/system/110708.png",institutionString:"King Saud University",institution:{name:"King Saud University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",slug:"reactive-oxygen-species",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Rizwan Ahmad",hash:"176adcf090fdd1f93cb8ce3146e79ca1",volumeInSeries:28,fullTitle:"Reactive Oxygen Species",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",publishedDate:"March 23rd 2022",editedByType:"Edited by",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",hash:"8b43add5389ba85743e0a9491e4b9943",volumeInSeries:27,fullTitle:"Vitamin K - Recent Topics on the Biology and Chemistry",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10799",title:"Phenolic Compounds",subtitle:"Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10799.jpg",slug:"phenolic-compounds-chemistry-synthesis-diversity-non-conventional-industrial-pharmaceutical-and-therapeutic-applications",publishedDate:"February 23rd 2022",editedByType:"Edited by",bookSignature:"Farid A. Badria",hash:"339199f254d2987ef3167eef74fb8a38",volumeInSeries:26,fullTitle:"Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9659",title:"Fibroblasts",subtitle:"Advances in Inflammation, Autoimmunity and Cancer",coverURL:"https://cdn.intechopen.com/books/images_new/9659.jpg",slug:"fibroblasts-advances-in-inflammation-autoimmunity-and-cancer",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Mojca Frank Bertoncelj and Katja Lakota",hash:"926fa6446f6befbd363fc74971a56de2",volumeInSeries:25,fullTitle:"Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer",editors:[{id:"328755",title:"Ph.D.",name:"Mojca",middleName:null,surname:"Frank Bertoncelj",slug:"mojca-frank-bertoncelj",fullName:"Mojca Frank Bertoncelj",profilePictureURL:"https://mts.intechopen.com/storage/users/328755/images/system/328755.jpg",institutionString:"BioMed X Institute",institution:{name:"University Hospital of Zurich",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:13}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:8},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"23",type:"subseries",title:"Computational Neuroscience",keywords:"Single-Neuron Modeling, Sensory Processing, Motor Control, Memory and Synaptic Pasticity, Attention, Identification, Categorization, Discrimination, Learning, Development, Axonal Patterning and Guidance, Neural Architecture, Behaviours and Dynamics of Networks, Cognition and the Neuroscientific Basis of Consciousness",scope:"Computational neuroscience focuses on biologically realistic abstractions and models validated and solved through computational simulations to understand principles for the development, structure, physiology, and ability of the nervous system. This topic is dedicated to biologically plausible descriptions and computational models - at various abstraction levels - of neurons and neural systems. This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. Particularly interesting are models of various types of more compound functions and abilities, various and more general fundamental principles (e.g., regarding architecture, organization, learning, development, etc.) found at various spatial and temporal levels.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11419,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"13818",title:"Dr.",name:"Asim",middleName:null,surname:"Bhatti",slug:"asim-bhatti",fullName:"Asim Bhatti",profilePictureURL:"https://mts.intechopen.com/storage/users/13818/images/system/13818.jpg",institutionString:null,institution:{name:"Deakin University",institutionURL:null,country:{name:"Australia"}}},{id:"151889",title:"Dr.",name:"Joao Luis Garcia",middleName:null,surname:"Rosa",slug:"joao-luis-garcia-rosa",fullName:"Joao Luis Garcia Rosa",profilePictureURL:"https://mts.intechopen.com/storage/users/151889/images/4861_n.jpg",institutionString:null,institution:{name:"University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",institutionURL:null,country:{name:"Turkey"}}}]},onlineFirstChapters:{paginationCount:14,paginationItems:[{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",doi:"10.5772/intechopen.105543",signatures:"Mary Dover, Michael Kishek, Miranda Eddins, Naneeta Desar, Ketema Paul and Milan Fiala",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80954",title:"Ion Channels and Neurodegenerative Disease Aging Related",doi:"10.5772/intechopen.103074",signatures:"Marika Cordaro, Salvatore Cuzzocrea and Rosanna Di Paola",slug:"ion-channels-and-neurodegenerative-disease-aging-related",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"81647",title:"Diabetes and Epigenetics",doi:"10.5772/intechopen.104653",signatures:"Rasha A. Alhazzaa, Thomas Heinbockel and Antonei B. Csoka",slug:"diabetes-and-epigenetics",totalDownloads:27,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"81099",title:"SK Channels and Heart Disease",doi:"10.5772/intechopen.104115",signatures:"Katherine Zhong, Shawn Kant, Frank Sellke and Jun Feng",slug:"sk-channels-and-heart-disease",totalDownloads:22,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80967",title:"Hot on the Trail of Skin Inflammation: Focus on TRPV1/TRPV3 Channels in Psoriasis",doi:"10.5772/intechopen.103792",signatures:"Lisa S. Martin, Emma Fraillon, Fabien P. Chevalier and Bérengère Fromy",slug:"hot-on-the-trail-of-skin-inflammation-focus-on-trpv1-trpv3-channels-in-psoriasis",totalDownloads:36,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80952",title:"TRPV Family Ion Channels in the Mammary Epithelium: Role in Normal Tissue Homeostasis and along Breast Cancer Progression",doi:"10.5772/intechopen.103665",signatures:"Sari Susanna Tojkander",slug:"trpv-family-ion-channels-in-the-mammary-epithelium-role-in-normal-tissue-homeostasis-and-along-breas",totalDownloads:19,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80157",title:"Structural Determinants for Ligand Accommodation in Voltage Sensors",doi:"10.5772/intechopen.102094",signatures:"Abigail García-Morales, Aylin López-Palestino and Daniel Balleza",slug:"structural-determinants-for-ligand-accommodation-in-voltage-sensors",totalDownloads:100,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"79690",title:"Mitochondrial Channels and their Role in Cardioprotection",doi:"10.5772/intechopen.101127",signatures:"Keerti Mishra and Min Luo",slug:"mitochondrial-channels-and-their-role-in-cardioprotection",totalDownloads:100,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"78415",title:"Epigenetic",doi:"10.5772/intechopen.99964",signatures:"Mehmet Ünal",slug:"epigenetic",totalDownloads:150,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"77443",title:"Cyanobacterial Phytochromes in Optogenetics",doi:"10.5772/intechopen.97522",signatures:"Sivasankari Sivaprakasam, Vinoth Mani, Nagalakshmi Balasubramaniyan and David Ravindran Abraham",slug:"cyanobacterial-phytochromes-in-optogenetics",totalDownloads:197,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"75979",title:"Spatiotemporal Regulation of Cell–Cell Adhesions",doi:"10.5772/intechopen.97009",signatures:"Brent M. Bijonowski",slug:"spatiotemporal-regulation-of-cell-cell-adhesions",totalDownloads:180,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"76646",title:"Functional Mechanism of Proton Pump-Type Rhodopsins Found in Various Microorganisms as a Potential Effective Tool in Optogenetics",doi:"10.5772/intechopen.97589",signatures:"Jun Tamogami and Takashi Kikukawa",slug:"functional-mechanism-of-proton-pump-type-rhodopsins-found-in-various-microorganisms-as-a-potential-e",totalDownloads:216,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"76510",title:"Evolution of Epigenome as the Blueprint for Carcinogenesis",doi:"10.5772/intechopen.97379",signatures:"Zeenat Farooq, Ambreen Shah, Mohammad Tauseef, Riyaz A. Rather and Mumtaz Anwar",slug:"evolution-of-epigenome-as-the-blueprint-for-carcinogenesis",totalDownloads:196,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"74615",title:"Diet-Epigenome Interactions: Epi-Drugs Modulating the Epigenetic Machinery During Cancer Prevention",doi:"10.5772/intechopen.95374",signatures:"Fadime Eryılmaz Pehlivan",slug:"diet-epigenome-interactions-epi-drugs-modulating-the-epigenetic-machinery-during-cancer-prevention",totalDownloads:377,totalCrossrefCites:0,totalDimensionsCites:1,authors:[{name:"Fadime",surname:"Eryılmaz Pehlivan"}],book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}}]},publishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",slug:"starch-evolution-and-recent-advances",publishedDate:"June 28th 2022",editedByType:"Edited by",bookSignature:"Martins Ochubiojo Emeje",hash:"f197f6062c1574a9a90e50a369271bcf",volumeInSeries:33,fullTitle:"Starch - Evolution and Recent Advances",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",institutionURL:null,country:{name:"Nigeria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",slug:"essential-oils-advances-in-extractions-and-biological-applications",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",hash:"742e6cae3a35686f975edc8d7f9afa94",volumeInSeries:32,fullTitle:"Essential Oils - Advances in Extractions and Biological Applications",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira",profilePictureURL:"https://mts.intechopen.com/storage/users/195290/images/system/195290.png",institutionString:"Museu Paraense Emílio Goeldi",institution:{name:"Museu Paraense Emílio Goeldi",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10841",title:"Hydrolases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10841.jpg",slug:"hydrolases",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Sajjad Haider, Adnan Haider and Angel Catalá",hash:"4e868cde273d65a7ff54b1817d640629",volumeInSeries:29,fullTitle:"Hydrolases",editors:[{id:"110708",title:"Dr.",name:"Sajjad",middleName:null,surname:"Haider",slug:"sajjad-haider",fullName:"Sajjad Haider",profilePictureURL:"https://mts.intechopen.com/storage/users/110708/images/system/110708.png",institutionString:"King Saud University",institution:{name:"King Saud University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10799",title:"Phenolic Compounds",subtitle:"Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10799.jpg",slug:"phenolic-compounds-chemistry-synthesis-diversity-non-conventional-industrial-pharmaceutical-and-therapeutic-applications",publishedDate:"February 23rd 2022",editedByType:"Edited by",bookSignature:"Farid A. Badria",hash:"339199f254d2987ef3167eef74fb8a38",volumeInSeries:26,fullTitle:"Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9753",title:"Terpenes and Terpenoids",subtitle:"Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/9753.jpg",slug:"terpenes-and-terpenoids-recent-advances",publishedDate:"July 28th 2021",editedByType:"Edited by",bookSignature:"Shagufta Perveen and Areej Mohammad Al-Taweel",hash:"575689df13c78bf0e6c1be40804cd010",volumeInSeries:21,fullTitle:"Terpenes and Terpenoids - Recent Advances",editors:[{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",institutionString:"King Saud University",institution:{name:"King Saud University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9731",title:"Oxidoreductase",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9731.jpg",slug:"oxidoreductase",publishedDate:"February 17th 2021",editedByType:"Edited by",bookSignature:"Mahmoud Ahmed Mansour",hash:"852e6f862c85fc3adecdbaf822e64e6e",volumeInSeries:19,fullTitle:"Oxidoreductase",editors:[{id:"224662",title:"Prof.",name:"Mahmoud Ahmed",middleName:null,surname:"Mansour",slug:"mahmoud-ahmed-mansour",fullName:"Mahmoud Ahmed Mansour",profilePictureURL:"https://mts.intechopen.com/storage/users/224662/images/system/224662.jpg",institutionString:"King Saud bin Abdulaziz University for Health Sciences",institution:{name:"King Saud bin Abdulaziz University for Health Sciences",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8094",title:"Aflatoxin B1 Occurrence, Detection and Toxicological Effects",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8094.jpg",slug:"aflatoxin-b1-occurrence-detection-and-toxicological-effects",publishedDate:"June 3rd 2020",editedByType:"Edited by",bookSignature:"Xi-Dai Long",hash:"44f4ad52d8a8cbb22ef3d505d6b18027",volumeInSeries:14,fullTitle:"Aflatoxin B1 Occurrence, Detection and Toxicological Effects",editors:[{id:"202142",title:"Prof.",name:"Xi-Dai",middleName:null,surname:"Long",slug:"xi-dai-long",fullName:"Xi-Dai Long",profilePictureURL:"https://mts.intechopen.com/storage/users/202142/images/system/202142.jpeg",institutionString:"Youjiang Medical University for Nationalities",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8004",title:"Nitrogen Fixation",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8004.jpg",slug:"nitrogen-fixation",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Everlon Cid Rigobelo and Ademar Pereira Serra",hash:"02f39c8365ba155d1c520184c2f26976",volumeInSeries:11,fullTitle:"Nitrogen Fixation",editors:[{id:"39553",title:"Prof.",name:"Everlon",middleName:"Cid",surname:"Rigobelo",slug:"everlon-rigobelo",fullName:"Everlon Rigobelo",profilePictureURL:"https://mts.intechopen.com/storage/users/39553/images/system/39553.jpg",institutionString:"São Paulo State University",institution:{name:"Sao Paulo State University",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8028",title:"Flavonoids",subtitle:"A Coloring Model for Cheering up Life",coverURL:"https://cdn.intechopen.com/books/images_new/8028.jpg",slug:"flavonoids-a-coloring-model-for-cheering-up-life",publishedDate:"March 11th 2020",editedByType:"Edited by",bookSignature:"Farid A. Badria and Anthony Ananga",hash:"6c33178a5c7d2b276d2c6af4255def64",volumeInSeries:10,fullTitle:"Flavonoids - A Coloring Model for Cheering up Life",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8170",title:"Chemical Properties of Starch",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8170.jpg",slug:"chemical-properties-of-starch",publishedDate:"March 11th 2020",editedByType:"Edited by",bookSignature:"Martins Emeje",hash:"0aedfdb374631bb3a33870c4ed16559a",volumeInSeries:9,fullTitle:"Chemical Properties of Starch",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",institutionURL:null,country:{name:"Nigeria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8019",title:"Alginates",subtitle:"Recent Uses of This Natural Polymer",coverURL:"https://cdn.intechopen.com/books/images_new/8019.jpg",slug:"alginates-recent-uses-of-this-natural-polymer",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Leonel Pereira",hash:"61ea5c1aef462684a3b2215631b7dbf2",volumeInSeries:7,fullTitle:"Alginates - Recent Uses of This Natural Polymer",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",institutionURL:null,country:{name:"Portugal"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8504",title:"Pectins",subtitle:"Extraction, Purification, Characterization and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/8504.jpg",slug:"pectins-extraction-purification-characterization-and-applications",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Martin Masuelli",hash:"ff1acef627b277c575a10b3259dd331b",volumeInSeries:6,fullTitle:"Pectins - Extraction, Purification, Characterization and Applications",editors:[{id:"99994",title:"Dr.",name:"Martin",middleName:"Alberto",surname:"Masuelli",slug:"martin-masuelli",fullName:"Martin Masuelli",profilePictureURL:"https://mts.intechopen.com/storage/users/99994/images/system/99994.png",institutionString:"National University of San Luis",institution:{name:"National University of San Luis",institutionURL:null,country:{name:"Argentina"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:317,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[],annualVolumeBook:{},thematicCollection:[{type:"book",id:"12222",title:"Advances and Challenges in Microplastics",subtitle:null,isOpenForSubmission:!0,hash:"a36734a551e0997d2255f6ce99eff818",slug:null,bookSignature:"Prof. El-Sayed Salama",coverURL:"https://cdn.intechopen.com/books/images_new/12222.jpg",editedByType:null,submissionDeadline:"July 1st 2022",editors:[{id:"347657",title:"Prof.",name:"El-Sayed",middleName:null,surname:"Salama",slug:"el-sayed-salama",fullName:"El-Sayed Salama",profilePictureURL:"https://mts.intechopen.com/storage/users/347657/images/system/347657.png",biography:"El-Sayed Salama is a professor in the Public Health School,\nLanzhou University, China. He is also a director of the Green Environmental & Energy Laboratory (GEEL) and a distinguished\nexpert of science and technology in the ecological industry, Gansu Province. His GEEL research work focuses on bioenvironmental science and bioenergy. He has several journal publications to\nhis credit.",institutionString:"Lanzhou University, Gansu Academy of Membrane Science and Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Lanzhou University",institutionURL:null,country:{name:"China"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"11668",title:"Mercury Pollution",subtitle:null,isOpenForSubmission:!0,hash:"0bd111f57835089cad4a9741326dbab7",slug:null,bookSignature:"Dr. Ahmed Abdelhafez and Dr. Mohamed Abbas",coverURL:"https://cdn.intechopen.com/books/images_new/11668.jpg",editedByType:null,submissionDeadline:"July 22nd 2022",editors:[{id:"196849",title:"Dr.",name:"Ahmed",middleName:null,surname:"Abdelhafez",slug:"ahmed-abdelhafez",fullName:"Ahmed Abdelhafez",profilePictureURL:"https://mts.intechopen.com/storage/users/196849/images/system/196849.jpg",biography:"Ahmed A. Abdelhafez, PhD, is an associate professor of the Department of Soils and Water Science, Faculty of Agriculture, New Valley University. He is one of the leading scientists in the field of biochar in the Arab region. He worked as a researcher at the Department of Environmental Researches, Agricultural Research Center (ARC), Egypt, for more than 10 years. Dr. Abdelhafez focuses mainly on agricultural production, environmental contamination control, risk assessment and biochar technology. He is a member of the National Committee of Soil Sciences and the Academy of Scientific Research & Technology, Egypt. He has published several research papers related to environmental contamination, risk assessment and potential remediation technologies.",institutionString:"New Valley University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"11666",title:"Soil Contamination - Recent Advances and Future Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"c8890038b86fb6e5af16ea3c22669ae9",slug:null,bookSignature:"Dr. Adnan Mustafa and Dr. Muhammad Naveed",coverURL:"https://cdn.intechopen.com/books/images_new/11666.jpg",editedByType:null,submissionDeadline:"June 9th 2022",editors:[{id:"299110",title:"Dr.",name:"Adnan",middleName:null,surname:"Mustafa",slug:"adnan-mustafa",fullName:"Adnan Mustafa",profilePictureURL:"https://mts.intechopen.com/storage/users/299110/images/system/299110.jpg",biography:"Adnan has completed his Ph.D in Soil Science from Graduate School of Chinese Academy of Agricultural Sciences, Beijing, China.\nHe is currently working as an Assistant Professor at Institute of Chemistry and Technology of Environmental Protection, Brno University of Technology, Brno, Czech Republic. He is simultaneously working as a Researcher with Department of Agrochemistry, Soil Science, Microbiology and Plant Nutrition (FA), Mendel University Brno and Institute of Environmental Studies, Charles University Prague, Czechia. \nHis research is focused on soil organic carbon (SOC) accumulation mechanisms, plant-microbe interactions, biochar production, and utilization for agricultural crop production and environmental remediation. He is actively involved in bioremediation of contaminated soils using organic and inorganic amendments in addition to exploiting plant-microbe interactions. He has published over 50 refereed journal articles, many of which sought to explore the effectiveness of innovative soil amendments and plant growth promoting rhizobacteria (PGPR) for improving crop performance and soil resilience under various abiotic stresses. He has been working for several renowned academic societies and enjoys early career in research.",institutionString:"Brno University of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Brno University of Technology",institutionURL:null,country:{name:"Czech Republic"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"22",title:"Business, Management and Economics",doi:"10.5772/intechopen.100359",issn:"2753-894X",scope:"\r\n\tThis series will provide a comprehensive overview of recent research trends in business and management, economics, and marketing. Topics will include asset liability management, financial consequences of the financial crisis and covid-19, financial accounting, mergers and acquisitions, management accounting, SMEs, financial markets, corporate finance and governance, managerial technology and innovation, resource management and sustainable development, social entrepreneurship, corporate responsibility, ethics and accountability, microeconomics, labour economics, macroeconomics, public economics, financial economics, econometrics, direct marketing, creative marketing, internet marketing, market planning and forecasting, brand management, market segmentation and targeting and other topics under business and management. This book series will focus on various aspects of business and management whose in-depth understanding is critical for business and company management to function effectively during this uncertain time of financial crisis, Covid-19 pandemic, and military activity in Europe.
",coverUrl:"https://cdn.intechopen.com/series/covers/22.jpg",latestPublicationDate:"June 27th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:2,numberOfPublishedChapters:19,numberOfPublishedBooks:1,editor:{id:"356540",title:"Prof.",name:"Taufiq",middleName:null,surname:"Choudhry",fullName:"Taufiq Choudhry",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000036X2hvQAC/Profile_Picture_2022-03-14T08:58:03.jpg",biography:"Prof. Choudhry holds a BSc degree in Economics from the University of Iowa, as well as a Masters and Ph.D. in Applied Economics from Clemson University, USA. In January 2006, he became a Professor of Finance at the University of Southampton Business School. He was previously a Professor of Finance at the University of Bradford Management School. He has over 80 articles published in international finance and economics journals. His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},subseries:[{id:"86",title:"Business and Management",keywords:"Demographic shifts, Innovation, Technology, Next-gen leaders, Worldwide environmental issues and clean technology, Uncertainty and political risks, Radical adjacency, Emergence of new business ecosystem type, Emergence of different leader and leader values types, Universal connector, Elastic enterprise, Business platform, Supply chain complexity",scope:"\r\n\tThe topic on Economics is designed to disseminate knowledge around broad global economic issues. Original submissions will be accepted in English for applied and theoretical articles, case studies and reviews about the specific challenges and opportunities faced by the economies and markets around the world. The authors are encouraged to apply rigorous economic analysis with significant policy implications for developed and developing countries. Examples of subjects of interest will include, but are not limited to globalization, economic integration, growth and development, international trade, environmental development, country specific comparative analysis, technical innovation and knowledge management, political economy analysis, and banking and financial markets.
",annualVolume:11971,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/87.jpg",editor:{id:"327730",title:"Prof.",name:"Jaime",middleName:null,surname:"Ortiz",fullName:"Jaime Ortiz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002zaOKZQA2/Profile_Picture_1642145584421",institutionString:null,institution:{name:"University of Houston",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"104262",title:"Dr.",name:"Chee-Heong",middleName:null,surname:"Quah",fullName:"Chee-Heong Quah",profilePictureURL:"https://mts.intechopen.com/storage/users/104262/images/system/104262.jpg",institutionString:null,institution:{name:"University of Malaya",institutionURL:null,country:{name:"Malaysia"}}},{id:"236659",title:"Prof.",name:"Monica Violeta",middleName:null,surname:"Achim",fullName:"Monica Violeta Achim",profilePictureURL:"https://mts.intechopen.com/storage/users/236659/images/system/236659.jpg",institutionString:null,institution:{name:"Babeș-Bolyai University",institutionURL:null,country:{name:"Romania"}}},{id:"202039",title:"Dr.",name:"Nahanga",middleName:null,surname:"Verter",fullName:"Nahanga Verter",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCwtQAG/Profile_Picture_1643101901237",institutionString:null,institution:{name:"Mendel University Brno",institutionURL:null,country:{name:"Czech Republic"}}},{id:"107745",title:"Emeritus Prof.",name:"Panagiotis E.",middleName:null,surname:"Petrakis",fullName:"Panagiotis E. Petrakis",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRzzaQAC/Profile_Picture_1644221136992",institutionString:null,institution:{name:"National and Kapodistrian University of Athens",institutionURL:null,country:{name:"Greece"}}},{id:"196259",title:"Dr.",name:"Ryan Merlin",middleName:null,surname:"Yonk",fullName:"Ryan Merlin Yonk",profilePictureURL:"https://mts.intechopen.com/storage/users/196259/images/system/196259.jpg",institutionString:null,institution:{name:"American Institute for Economic Research",institutionURL:null,country:{name:"United States of America"}}}]},{id:"88",title:"Marketing",keywords:"Consumer trends, Consumer needs, Media, Pricing, Distribution, Branding, Innovation, Neuromarketing",scope:"