\r\n\tRNA therapies evolved as profitable and widely applicable individualized treatment solutions. Moreover, RNA-based therapeutic vaccines (e.g., against SARS-CoV-2 infection) have been proven to be safe and effective, and several of them are approved by the United States Food and Drug Administration (FDA). \r\n\tThis book aims to present distinct classes of RNA therapeutics, ranging from single-stranded antisense oligonucleotides (ASOs), and subclasses of RNA interferences (miRNAs and other RNAi), to in vitro transcribed mRNAs and RNA vaccines. Also, it will present some of the challenges in RNA drug engineering, delivery, and specificity. Additionally, the improvement of pharmacological effectiveness will be discussed. Monumental breakthroughs in molecular biology, computational chemistry, bioinformatics, and individualized genomics, which undoubtedly propelled RNA therapeutics through the commercialization stage, will also be examined in this book. \r\n\tRNA therapeutics have had a significant impact on medicine, the economy, and overall public health; they are becoming prescription drugs, and this holds great promise for modernizing healthcare.
",isbn:"978-1-80355-658-1",printIsbn:"978-1-80355-657-4",pdfIsbn:"978-1-80355-659-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"fbffd7b2f97a65ffb0901de38a65bed0",bookSignature:"Prof. Irina Vlasova-St. Louis",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11813.jpg",keywords:"RNAi, miRNA, RNA Interference, ASO Aptamers, Decoys, Genetic Diseases, Cardiovascular and Neurological Diseases, Infectious Diseases, Cancer, Clinical Trials, Moderna, Pfizer",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 22nd 2022",dateEndSecondStepPublish:"May 20th 2022",dateEndThirdStepPublish:"July 19th 2022",dateEndFourthStepPublish:"October 7th 2022",dateEndFifthStepPublish:"December 6th 2022",remainingDaysToSecondStep:"3 days",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Accomplished biomedical specialist with a post-PhD from the University of Minnesota, USA. Dr. St. Louis is a COVID-19 Associate, sponsored by the Association of Public Health Laboratories and the Center for Disease Control and Prevention, USA. She leads the molecular surveillance program of novel SARS-CoV-2 variants. She secured more than $5M USD in grant funding from USA government agencies (NIH, NIAID, NINDS).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"211159",title:"Prof.",name:"Irina",middleName:null,surname:"Vlasova-St. Louis",slug:"irina-vlasova-st.-louis",fullName:"Irina Vlasova-St. Louis",profilePictureURL:"https://mts.intechopen.com/storage/users/211159/images/system/211159.png",biography:"Dr. Vlasova-St. Louis earned her MD and Ph.D. degrees from Ural State Medical Academy, Russia. She completed her postdoctoral training at the University of Minnesota, USA, and fellowship sponsored by the Lymphoma Research Foundation. She served as an Assistant Professor at the Department of Medicine, University of Minnesota. \r\nDr. Vlasova-St. Louis has expertise in several biological disciplines including infectious diseases, immunology, and bioinformatics. By integrating state-of-the-art techniques such as next-generation sequencing, she made numerous biomedical discoveries studying normal and pathological conditions at the molecular, cellular, and organismal levels. \r\nCurrently, Dr. St. Louis is a COVID-19 Associate, sponsored by the Association of Public Health Laboratories and the Center for Disease Control and Prevention. She leads the molecular surveillance program of novel SARS-CoV-2 variants. Additionally, she is conducting research at Johns Hopkins University within the Advanced Academic Program: Individualized Genomics and Health.",institutionString:"University of Minnesota",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Johns Hopkins University",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"19",title:"Pharmacology, Toxicology and Pharmaceutical Science",slug:"pharmacology-toxicology-and-pharmaceutical-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"225753",firstName:"Marina",lastName:"Dusevic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/225753/images/7224_n.png",email:"marina.d@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3569",title:"Biodegradation",subtitle:"Life of Science",isOpenForSubmission:!1,hash:"bb737eb528a53e5106c7e218d5f12ec6",slug:"biodegradation-life-of-science",bookSignature:"Rolando Chamy and Francisca Rosenkranz",coverURL:"https://cdn.intechopen.com/books/images_new/3569.jpg",editedByType:"Edited by",editors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"73306",title:"Self-Government in Yugoslavia: The Path to Capitalism?",doi:"10.5772/intechopen.93673",slug:"self-government-in-yugoslavia-the-path-to-capitalism-",body:'
1. Introduction
Emerging after World War II, Yugoslavia was destined to be qualified as a capitalist country. Its openness to the world market, market-framed consumption, self-management that introduced democracy to economic entities, and supremacy over the working class are just a few things that have always fueled suspicion about the socialist character of Yugoslavia. However, the same qualification was given from different sources and with different intentions: sometimes as a stigma and sometimes as a praise. The list is long: as early as 1951, a prominent Trotskyist economist Ernest Germain (Mandel) [1] wrote that the emergence of the restoration of capitalism in Yugoslavia was imminent.1 In 1963, a Chinese party leadership said that there had been a “counter-revolution” and “replacing of socialism with capitalism” in Yugoslavia [2]. Paul Sweezy [3], a well-known American economist, also argued in the panorama of socialist countries in the 1960s that the existing socialist countries (except China) had opened the door to the invasion of capitalist content, and Yugoslavia did it as well. Now, let us do a little time traveling: Ernst Lohoff [4], a modern German Marxist, used the term “ideeller Gesamtkapitalisten” (ideal total capitalist) to describe the Yugoslav situation, that is, to represent the communist party which took care of the “social capital.”
This does not mean that the list is exhausted. The mentioned assessments definitely stand for certain elements of the historically created situation in Yugoslavia. Yet, they contain certain reductions and do not capture the procedural character of the existence of capitalist aspects in Yugoslavia; if it is claimed that capitalism existed per se in Yugoslavia and a priori a sign of equality is placed between capitalism and Yugoslav socialism, then some important interpretation dimensions are lost. Socialist Yugoslavia disintegrated at the end of the 1980s, and that already created the impression of predetermination, that is, the absence of any alternatives. However, capitalism in self-governing socialism arose as an unplanned outcome of various socio-economic determinations and certain conflicts that were actually the articulation of the same conflicts. Capitalism in Yugoslav socialism could not be perceived on the basis of predetermined paths. A conceptual distinction should be made between capitalism and the existence of elements of capitalism: whatever the definition of capitalism we give, it represents a kind of socio-economic completeness and wholeness.
First, the paper presents a conceptual clarification based on which we have enframed the selected problems. After that, we are going to determine two ideological foundations of the Yugoslav system (self-management and social property) and describe, but not in-depth, the characteristic stages of Yugoslav socialism which relate to the chosen topic of our work. The following sections will contain discussions of the selected moments that show strong presence of capitalist elements which truly anticipate later capitalism on the ruins of Yugoslavia (reliance on the volatile world market as the supreme arbiter of economic rationality, the supremacy of banking and financial capital over social reproduction, the presence of labor market elements). This chapter does not present empirical investigations, but the claims are supported by empirical illustrations. We will neither discuss the causes of the collapse of Yugoslavia, nor the phenomena of “imitated modernizations.” We will only treat the problem of the existence of capitalism in self-governing Yugoslavia on the basis of selected examples.
2. Some conceptual clarifications
Capitalism has always been prone to different interpretations. Max Weber, Werner Sombart, Joseph Schumpeter or Milton Friedman formulated the essence of capitalism in different ways. Moreover, capitalism is currently experiencing renewed and heterogeneous interpretations, some of which have even been questioning the existence of a “unitary definition of capitalism” due to “heterogeneity” [5].
Nevertheless, when discussing about Yugoslavia, we must turn to the author who is valued as the supreme landmark in terms of self-governing socialism, namely, Karl Marx because in this way the effects can be measured immanently, that is, we confront Yugoslav socialism with our own ideological self-understanding. However, Marx did not use the term capitalism as much as he referred to the “mode of capitalist production.” In his perspective, structural determinations of capitalism imply certain social relations which mean that: (1) there must be wage labor which conditions (a) that direct producers are separated from the means of production and do not make investment decisions and (b) there is exploitation of direct producers in the sense that those who have the means of production command the use of labor, that is, achieve “exploitation as domination” [6], (2) there is competition between capital in the market, (3) “monetization of the economy” and the “financial mode of existence of capital” [7], and (4) ideological infrastructure that supports structural determinations.
Socialism implies the appearance as well as a set of different intervention practices that abolish the specified conditions of capitalism. The same practices imply a synthesis of different interventions both in the field of ideology/rights/politics (e.g. disempowerment of property rights) and in the economic domain (e.g. creation of nonantagonistic relations in production, creation of socio-economic conditions for appropriation of surplus labor of direct producers). Therefore, socialism implies a deep-seated political-economic transformation: that was the intention of the Yugoslav communists as well. Yet they (like many others) understood socialism as a “transitional state” between capitalism and communism, that is, as a process that led to the goal of history. In other words, socialism was viewed both procedurally and teleologically: the communist party was considered to be the one that was “supposed to know” the paths of history leading to the desired goal.
At least two things need to be clarified here.
First, although the ideologists of Yugoslav self-governing socialism were not clear about this, it must be said that capitalism and (self-managing) socialism exist in the same conceptual field. Both are based on what the Yugoslav communists called “commodity-based production.” However, the same communists projected the possibility of turning commodity-mediated collective organizations into a means that could be harnessed in the course of teleologically understood history. Successful instrumentalization of the commodity-principle is the main prerequisite for socialism not to regress into capitalism. Socialism represents a certain relationship between fine-tuning of instruments (commodity/market) and anticipated goals (communism). It is important to mention that the criticism that affects the ideological projections of the Yugoslav communists from leftist perspectives centers on that they managed to realize legal and political interventions with respect to the fabric of society, but not epochal changes in terms of transforming the structure of productions.
Second, Yugoslav ideologists like Edvard Kardelj [8] referred to social capital2. The semantic context of this term brings us back again to Marx, who in Volume III of Capital wrote about the self-transformation of capital (about joint-stock companies as forms of socialization of capital) “within the capitalist mode of production itself.” “Cooperative firms” and “joint-stock companies” are signs that capitalism has come to its own “superseding” independently of the property rights of the means of production, which means that “workers in the association become their own capitalists.”3
The same stands for the Yugoslav communists. The above given arguments indicate the existence of capitalism and socialism on the same soil. Does this mean that there is capitalism in socialism or vice versa, socialism in capitalism?
Johanna Bockman [11, 12] raised a provocative thesis stating that “neo-liberalism”4 does not only have transnational roots but also “leftist origins.” She explicitly mentions Yugoslav economists as interlocutors who, because of greater intellectual freedom in the former Yugoslavia, had the opportunity to familiarize themselves with the neoclassical logic of Western economists and, during the intensive communication and scholarship, thus also became acquainted with the appropriate economic techniques. In addition, more liberal worldview that emerged in Yugoslavia after the break with Stalin resulted in systematic translations of economic literature in the West. This would then mean that the discursive constructions of liberal economists in Yugoslavia, who were attacking the system anyway, were an inevitable “source” for the renewal of liberal capitalism. Or it meant that one of the most famous Yugoslav economists (who regularly used the neoclassical technique), Branko Horvat, a theorist of self-management, malgré lui contributed to the emergence of neoliberalism. Bockman is not surprised that the Yugoslav self-governing enterprise has become an exceptional subject for various economic theorists in a capitalist perspective: neoclassical discourse has followed with great interest the models of employees being “their own capitalists” [14].
Bockmann’s thesis is problematic as it overemphasizes neoclassical discourse (which cannot be equated with Hayek’s Austrian discourse who played a significant role in the reshaping of the framework of today’s “neoliberalism”). Moreover, changes of socialism toward capitalism or the affirmation of capitalism can be understood only by measuring the relationship between structure and agencies in Yugoslav society. The proposition that local economic discourse could contribute to the emergence of “neo-liberalism” should not be questioned, but it is of greater significance to notice that (at least if we accept that we can talk about embryos of “neoliberalism” in Yugoslavia) different social agencies were the “bearers” of this constellation.
However, there is an idea in Bockman’s thesis that is important to us: it actually suggests that there is ante litteram capitalism on a discursive level. As for the relevance of discursive articulations, we can say that discourses have a function of revelation. Indeed, if we take a look at, for example, some economic and political discourses in the 1960s (regardless of Bockman), they actually anticipate transitional discourses of the late 1980s when, after the collapse of self-management, there was official transition to capitalism and ideology propagated definite supremacy of capitalism with respect to socialism. Or, if we evaluate the various economic discourses in the 1960s regarding the international market, then we see the absolutization of such export orientation, which is also emphasized in the post-socialist order as a panacea.
Broadly speaking, Bockman’s argument is the basis for our further argumentation: the “transition period” was burdened with the “recurrences of the past” as ideologists said many times before (hence, there is always a path-dependent logic that determines the present) and at the same time it was determined by the elements of future that later became unambiguously “capitalist.” Thus, the “transition period” develops diachronic time sequences as well as synchronous temporality. It is a temporal framework in which we can thematize the presence of capitalism in socialist Yugoslavia.
3. Ideological fundamentals throughout the history
There were two fundamentals of the system: self-management and social property. In both cases, the system saw itself as a pioneer [15]. The emergence of capitalism in Yugoslavia can only be understood as an expression of the collapse of the synthesis between self-management and social property.
In a nutshell, self-management meant that the “working man” in various associations was the main subject of the economic domain and the axis of all life in general [16]. At the same time, self-management as the microfoundation was the basis for macro-construction, that is, for the “self-government society.” There was, therefore, an intention to expand self-management to the entire society, to transfer the norms of labor socialization to other (say, communal) levels, too.
Self-management was the negative fundamental of the system: Yugoslav socialism was considered to be significantly different from both the Soviet type of state socialism and the organization of labor under capitalism. Self-government was supposed to realize analogous goals as well as capitalism and state socialism (economic rationality, productivism), but in a significantly superior way. Self-management goals can accordingly be classified in the following modes:
improving efficiency while creating the necessary conditions for calibrating economic motivations—self-managing enterprise overcomes various deficits of capitalist enterprise in terms of efficiency (according to some data, the total productivity of production factors in the period 1953–1965 in capitalism was 3.3, in state socialism it was 3.0, and in self-management it was 4.7 [17], p. 170). Thus, modern economic discourse recognizes in capitalism the acute problem of “incomplete contract” [18] in terms of organization of production and control by capitalists, but in self-management this problem disappears as there is no need for constant supervision of workers who are “their own capitalists”; they are capitalists with the right motivation but without capitalism;
the achievement of just distribution and egalitarianism, starting from the micro to the macro level (the Gini coefficient in the mentioned period was 0.40 in capitalist countries, 0.26 in “statist countries,” and 0.25 in self-management) [17], p. 171; self-governing socialism wanted the same thing as transformed capitalisms after World War II, the prosperity, but in a different way;
some theorists and strategists even had the idea of abolishing the division of labor;
in the philosophical sense, the realization of “humanism,” i.e. disalienation, or overcoming various forms of alienation in capitalism.
The conception of self-management was, in certain aspects, on the ground of capitalism, but for the purpose of transcending to the capitalism, and this can be proved with the thinking of Horvat who has already been mentioned here (he once managed federal Yugoslav planning institutions to become an “internal opposition” to the system). It is characteristic that, unlike liberal economists who believed in the late 1980s that entrepreneurship was possible only with the existence of consistently derived private property (according to the Austrian concept), Horvat insisted on self-management until the end of socialism as an adequate framework for collective entrepreneurship [19, 20]. Still, this concept of “collective as entrepreneur” does not exclude personal initiative: on the contrary, this way self-management surpasses capitalism, which enables far-reaching inclusion of personal initiatives in the collectivity. Self-government in the context of “commodified production” aimed to establish efficient and fair use of capital—but always without capitalism.
Social property was more difficult to interpret because it had far fewer predecessors than self-management. We can understand social-property as a critique of private and group property in the sense that social-property is inclusive in relation to the exclusivity of the mentioned forms of property. Strictly speaking, “society” was the bearer of property and this clearly had an anti-capitalist trait, but it was not easy to operationalize in the context of the increasingly intensifying market in Yugoslavia. A solution was found in the separation of economic and legal aspects of property, which is again (at least partially) analogous to a joint-stock company in capitalism where shareholders are the legal holders of property, but only management can establish “economic control.”5 It can be said that the combination of self-management and social-property had double function: (a) finding a unique Yugoslav position toward capitalism and state socialism and (b) overcoming the antagonism between capital and labor as well as divergence between socialized economy and private appropriation6.
Self-management was gradually introduced after the conflict with Stalin in 19487 and, as often described in the literature, with a great burden of the past it meant: (a) the legacy of pre-war Yugoslavia which was a peripheral capitalist country, (b) great destruction in World War II, brutal destruction of the existing capital which caused a lack of capital in the context of accelerated industrialization, (c) high disparities, that is, divergences in the development between different parts of a country with a federal structure. The Yugoslav communists knew that the weak working class, which was necessarily recruited from the peasantry in the agrarian country, lacked cognitive resources as well as habitualization for the realization of self-management. However, they assumed that the self-management processes could involve learning-by-doing principle due to the absence of time for education. Alternatively, we can say that the practiced self-management is not only a combination of goal-rational actions but also the creation of “endogenous preferences,” that is, the creation of subjectivities for individual economic initiatives. Worker subjectivity is a dynamic category8 and it can change depending on institutional conditions; dynamic self-management will just develop harmony between social justice and effectiveness.
For the genealogical approach, it is purposeful to adopt the well-established scheme9 that shows briefly the dynamics of self-management with the macroelements relevant for our analysis:
1945–1948: industrial take off; pure imitation of state socialism including state-property (in 1948 the industry was 100% state-owned); the plan directly and as legal imperative directed the economy, orders the proportions;
1948–1965 [28]: introduction and affirmation of self-management; double decentralization both in terms of territorial organization and in terms of basic economic entities; existence of significant economic growth; plan/market axis in the sense that the plan sets the “basic proportions” of economics, however, self-management was never implemented consistently and, in addition, it always carried an inherent sign of the politics “from above”; at the beginning of the 60s, the first signs of exhaustion of the great industrial take off from the 50s appeared, that is, the cycle that brought primarily (unrepeatable) high growth was exhausted; the necessity of choosing a new direction in terms of economics, which would create a reform in 1965 (reforms were “endemic” in socialism anyway, as Adam Przeworski says);
1965–1974: the inflammation of hard crisis (industrial production grew at a rate of 12.7 in the period 1952–1964, and at a rate of 7.1 in the period 1964–1978 [29]); strong turn toward the world market especially in search for foreign aid; the modes of introducing market categories gave enormous power to the banks; a break in the “plan-market axis” in terms of the gradual disappearance of comprehensive planning; stabilization of high unemployment level; survival of regional disparities; high rate of inflation and significant social polarization; strong presence of elements of capitalism but without the appropriate capitalist rationality that would “domesticate” the results of deregulated markets; loss of socialism contours;
1974–1980: constitutional completing of national states of the existing federalism with the modes and effects of confederalization; strengthening of economic sovereignty of federation constituents; “nationalization” of different economies with mimetic reheating of political conflicts between national oligarchies (politology employs here the term of “polyarchy”); exposition to advancing international economic crisis.
1980–…: “perpetuation of Yugoslav crisis”; condensation of aggressive economic nationalism among the entities of federation leading to final disintegration; futile efforts to reconstitute Yugoslavia; openness to capitalism completed.
4. World market as a generator of capitalism in self-governing socialism: dependence
Capital circulation in the world market represents a significant source of capitalist elements in socialist countries. However, we should demystify a myth that persists in a permanent autarchy of socialism in which strong ideology has control over the economic communication with capitalism system: this bears no reality in the context of “red globalization” [30, 31]. Yugoslavia appears here as an exception, but with regard to it, we can only discuss about gradual differences in overall socialist world.
In any case, it is true that, as early as in 1950, Yugoslavia rapidly integrated into the world capitalist system, which was under the domination of the victorious USA. There were different forms of accession: integration into economic institutions of “liberal internationalism” (Coal Committee of the Economic Committee for Europe, loans from the World Bank, the IMF and the US Export–Import Bank, as well as British banks [32]), bilateral treaties; it was indicative that there was a very favorable balance of payment in 1948 (the period which, according to many authors, is believed to be the period of autarchism). The following year, there were “efforts to find new markets in the European Economic Community and the United States for… minerals… and timber; agreed to the dinar-dollar exchange rate…so as to obtain IMF credits” [33]. These moments are only examples, but they are representative enough to demonstrate that self-governing Yugoslavia was part of the capitalist world system and that it acted in compliance with capitalist norms.
However, there are phases that shed light on capitalist aspects: by 1965, although external financing was important, there was a certain balance between internal and external sources of financing and the debt was 1.2 billion of dollars until that period [34]. It can be said that there had been “shallow integration” by that time despite gradual integration into the world market determined by capital, and that it was not until 1965 that “deep integration” took place.10
Changes in integration in capitalist world market were depended on the processes in the early 1960s. Namely, the economic growth as well as the growth rate was slowed down, and it was obvious that the development direction should be reconstructed. One group of theorists and politicians, who emerged from liberal milieu, focused their attention to the world market as an ultimate criterion of economic rationality. They drew attention to the fact that the products of self-governing companies should be tested, in other words, the results of self-managers should be proven in the market with dominant capitalist rationality and absence of communist ideas. In addition, the highest-level political officials also warned about the necessity for reorientation in a domain such as tourism in order to attract foreign investments [36]. Other theorists and politicians (in scientific literature referred to as “developmentalists”) have emphasized the importance of a phenomenon commonly referred to as “import substitution industrialization,” which would imply a distance between Yugoslav economy to the capitalist dimensions of world market and focus on national resources.
The 1965 reform brought the triumph of economic liberalization. It can be said that this also meant a certain victory for economists and politicians of liberal provenance who emphasized the inevitability of the competitiveness of the Yugoslav economy in the world market (exports in 1970 amounted to about 15.1% of GDP [37]). A number of typical deregulatory measures were adopted with the aim of improving efficiency of the foreign trade system, devaluation of dinar was realized, and as the official documents emphasized “free disposal of foreign exchange,” “foreign exchange self-financing,” and “interbanking foreign exchange market” should be achieved [38]. Import was also increased and in the period between 1961 and 1965 it was covered with export in the range of 74% and then the same coverage was gradually reduced [28], p. 104. An institution, which was completely unknown in socialist countries, appeared as an expression of new orientation, namely, joint business venture (in accordance with the legislation, there was a certain restriction that “the foreign partner could not have more than 49% of the total value of joint investments”). Simultaneously, joint ventures were unknown source of financing as well as the form of cooperation with foreign capitalist companies for profit purposes. In the period between 1967 and 1980 “joint ventures were signed to the value of 49,255 million dinars, of which the foreign participation amounted to 10,264 million dinars or 20.74% of the total” [39]. Actually, the level of investment made by different foreign multinational companies (their structure reflected the structure of foreign trade of Yugoslavia with a significant presence of Western Germany and USA) varied but it represented a significant source of financing. Therefore, it can be said that with certain restriction, self-governing socialism found the source of financing based on the profit criteria; therefore, it can be said that Yugoslavia, following market-economic rationality, used loans for investment and not for consumption.11
However, despite the results (for example, state property definitely disappeared with the reform and became social property), major problems arose. The system of the federal state was decentralized in such a way that the possibility of joint-federal planning was increasingly lost, that is, there was a fatal fragmentation between the members of the Yugoslav federation who were divided by nationalist interest. Decentralization is a principle that can be justified, but at that time it acquired a pronounced disintegration-nationalist meaning: the focus was on the work that merged the nationalist affirmation of justice with market criteria. Favoring of the market often had a national character, the perspective of those who benefited from inclusion in the world capitalist system. Moreover, it should be noted that the IMF, which of course implemented the norms of capitalist rationality in terms of debt, acted as a “promoter” of capitalism but internal decentralization of Yugoslavia as well12. In the meantime, Yugoslav economy became deregulated in significant elements losing chains between market and plan; the federation apparatus was losing its competencies and it could eventually manage only the monetary flows. It entered volatile world market with strong competitive pressures, but with subsequently drastically increased American interest rate, which resulted in the countries in debt being in undesirable situation [41], or with oil price shocks, Yugoslav economy was literally unprotected from contingent shocks of the world system. Some Yugoslav economists metaphorically called Yugoslav economy a laissez-faire system indicating to the absence of planning dimension, Rusinow [42] even used the term “laissez-faire socialism” ironically.13 During the 1980s, which were important because the world economy was also restructured and profound transformations were commonly associated with the offensive of Ronald Reagan and Margaret Thatcher (who demolished post-war Keynesian compromise), Yugoslav economy was strongly affected.14 Yugoslav economy with aspects of deregulation competed in the world market, its actors had to adopt the roles of capitalist subjects, and at the same time, Yugoslavia as a whole was left with and without capitalist resilience regarding the relationship between market and plan—we must not forget that the plan exists in capitalism as well (corporate planning), although it develops in a different way compared to socialism. Yugoslav communists wanted “endogenous planning”15 (as opposed to imposed exogenous planning), and in the 1970s and 1980s they even legally forced basic economic units to implement planning, but planning in Yugoslavia became less and less possible. Socialism projects planning as a control of economic flows; planning is a guarantee to reduce waste, and self-management promised virtuous cycles between plan and market—however, these projections increasingly failed.
5. Banks as the institutionalization of “financial mode of capital”
As we have already seen, there were various forms of financing economic activities in the 1960s and they were related to the profit motive, that is, to capitalist incentives, with the constant intensification of dependence on the world market. However, banks in Yugoslavia played a special role in the entire constellation in the 1960s. The background to the problem was the argument about adequate sources of financing because some Yugoslav actors, at the same time, proposed institutionalization of the capital market as in capitalism, which would imply a consistent market distribution of funds for investment purposes.
The capital market was often a subject of various discussions regarding the market socialism. Namely, the advocates of market socialism believe that it is possible to develop market but without transition into capitalism, that is, it is possible to affirm market without capitalism (unlike those critics who believe that market socialists are inherently “capitalist roaders” [45, 46]). The capital market can be rationalized in the system in which there is a synthesis of worker-control and decentralized market.
The capital market was not introduced in Yugoslav self-managing socialism. The argument for this was that, in that case, a self-manager would just be a pure “shareholder” of “social capital.” At the same time, liberal economists discussed about that as being a symptom of a significant problem because the expansion of real income could not be converted into investments as it was converted into personal consumption and status of goods. This constellation encouraged some researchers to claim that Yugoslav self-management belonged to the sphere of “market socialism” [33], p. 169, due to the lack of capital market. The consumer market articulated personal consumption based on the logic of prices; there was a significant liberalization of the price mechanism in foreign trade as well, but the market mechanisms and allocative efficiency of the market were not applied in production factors. It is interesting that there is a belief even by the critical left that it was a mistake to give up on the introduction of the capital market [40], p. 291, because with appropriate infrastructure the engaged self-managers could rationalize the distribution of funding sources and control the use of resources exposed to irrational spending, that is, waste of resources. The result of this logic is that the capital market would enable rational use of social capital, which would finalize the idea regarding the targeted use of capital, but without transformation into capitalism. Conceptually, this argument emphasizes that it is completely wrong to think within the framework of a rigid dichotomy between plan and market, that is, the fact that there was no plan in Yugoslavia as coercive encompassing of economy does not mean that it represented market socialism.
However, coexistence between market and socialism has never been present without certain tensions. Actually, it was this context that the banks appeared in the 1960s as exclusive financiers and as financial entities in the absence of capital market. Banks, as financial institutions, did not have earlier a constitutive role in financing investments in Yugoslavia, they were simply a part of “bureaucratic planning”: they did not prevent “irrational” allocation of resources, nor they could sanction “insolvencies.” However, intensive liberalization in 1965 resulted in banks being analyzed from a new perspective. Actually, they were supposed to become an organic part of the “integrated self-management system” and achieve harmony between market and self-management.16
Commercial banks began to operate in accordance with capitalist norms, that is, they could borrow from the banks abroad and take deposits in foreign currency, thus being able to finance domestic companies and mediate between savings and investments [37], p. 399. The reform of the banks was intended to: (a) consequently complete the decentralization process that took place in Yugoslavia at various levels, (b) ensure price stability, and (c) prevent the supremacy of any institution that finances the Yugoslav self-managing economy. In other words, the territorial and functional organization of the banks was supposed to ensure the final triumph of self-management, that is, the victory of the working man who mastered the entire social reproduction. The self-managers actually gave a part of the “social capital” to the banks in order to rationalize the allocation of resources—that was the official argument.
However, if we try to understand the intention of financing investments and transfer of savings into investments as a “financial root” of self-management, then it can definitely be said that the reform failed. Banks in fact became superior to self-managing entities by becoming dominant managers over significant segments of “social capital” allowing them to establish control over self-governing entities, even to “blackmail” self-governing actors. “Banking oligopoly” (known in the literature) became a relevant social phenomenon that soon became a political problem. This is proven by data: banks’ funds in financing investments were about 7.0% in the period 1952–1958, but in the period 1964–1971, the same percentage was 30 to 41% [28], p. 99. Therefore, it should be added that “joint work” increasingly depended on financing based on foreign funds: in the period 1971–1975, foreign sources of investment increased to 28% [49].
Banks were criticized many times and most of those criticisms were political and were addressed to monetary technocracy in banks. However, the mentioned technocracy (which has been criticized many times for being “alienated” from joint work) just implemented rationality norms in the newly developed situation. In fact, it seems as if, at this stage, the discourse of differentiation between capitalism and socialism is reversed. Namely, if we were to analyze the language of the debates of that time, then we would have the impression that the discussions were conducted in a discursive perspective or of the Finance capital of Rudolf Hilferding (1910), or in the perspective of later and present elements of “financialization.” In fact, there were aspects of both retrospective and anticipatory forms of financial capital in Yugoslavia.
In Yugoslav socialism when self-criticism always had strong forms, certain influential actors (such as Kardelj who is already mentioned here) analyzed the penetration of the banking capital as a prelude to capitalism. So, it should not come as a surprise that the measures adopted in the 1960s were homologous to the economic-political measures realized during the transition in post-socialist countries in the 1990s (control of public finances for the purpose of curbing inflation, etc.) and other implemented measures of economic policy that anticipated later transition into capitalism (relying on IMF loans, encouraging of exporting-based economy, “restrictive monetarism,” cutting of import and budget, or lessening of welfare provisions, etc.). In fact, the same measures can be compared with the orientation schemes of late transition to capitalism. Capitalism was structurally present as anticipation.
6. Unemployment: elements of capitalist labor market?
In 1965, a dissemination of certain market criteria (in the sphere of housing construction17 in the domain of service activities, etc.) was welcomed. Consequently, certain forms of social differentiation were intensified resulting in the destruction of egalitarianism as a socialist principle. The system made efforts to regulate income differences within the firm, i.e. the range of income, which provided certain forms of intra-firm egalitarianism, but the deregulated market created different forms of “rents” (which also implies different forms of inequality and exploitation).18 Self-management socialism raised its flag which wrote “reward according to work” (this form was later changed and became “reward according to the results of work” [40], p. 345, which implies different perspective), but the “system of rents” created such situations in which income did not depend on work but on the branch of economy in which a “self-managing worker” performed his activities (locational rent). There were forms of intra-firm interest, but the workers in certain firms defended their own interests without respecting the interests of the working class as a whole. Relevant research indicated a tendency of agents of individual firms to behave as subjects of capitalist firms, namely, as agents of atomized firms with conflicting interests (this allows us to discuss about “fragmented” and “atomized” self-management). Although some research showed that “competitive pressures” in self-governing company was “relatively weak” [46], p. 314; [51], p. 243, in comparison to the capitalist firms, this did not imply expansion of solidarity in the form of socialist egalitarianism. Solidarity did not overwrite atomized interests. In capitalism, “choice in the small does not provide choice in the large”19, which means that there was a structural possibility for individual rationality to be converted into “collective irrationality” (Przeworski), or into collective myopia, and Yugoslav self-governing socialism underwent that change.
A special attention here should be paid to unemployment. It is certain that it was connected with the mentioned reform as it can be seen from data: the number of unemployed people in 1965 was 265.000 and in 1968 it was 315.000 [28], p. 105. Simultaneously, the unemployment rate increased dramatically in the underdeveloped countries. In Macedonia, which was part of Yugoslavia, the unemployment rate in 1952 was 6.3%, in 1965 it was 13.5% (with a tendency to increase), and in 1974 it was 19.7%, and in Slovenia, the unemployment rate in the same year was only 1.4% [37], p. 394.
However, it must be said that the problem of unemployment (which is not interesting for us due to its phenomenology but in the light of the presence of capitalism) has attracted constant attention since the beginning of the second Yugoslavia, that is, since 1965. The Communist Party was faced with the mentioned problem earlier so it came to the conclusion that it was impossible to avoid unemployment, that is, it concluded that there was an “inevitable”/functional unemployment rate in self-governing socialism as well. Even in the period before 1965, when the growth rate in the social sector (4%) was high, job could not be provided to a great number of people who came from rural to urban areas. After the mentioned reform in the social sector, the employment rate in the period increased at a rate of 0.8%, which was less than the growth rate of the labor force; moreover, if we compare the employment rate with the growth rate of the entire population, then we could see negative rate of −0.1% [28]. The fact causing the concern was that around 50% of unemployed people were young. If we start from the fact that the “inevitable” unemployment rate in capitalism at that time was 4–5%, then the relevant fact is that the same rate in Yugoslavia was around 7% [40], p. 294, or that in 1968, around 47% more people were looking for employment in comparison to the percentage before reform [54], which indicates to the collapse of employment policy. Statistics showed permanent, long-term unemployment, but research, at the same time, indicated to excessive unemployment in companies (contrary to Benjamin Ward’s theory of self-governing firms, which suggested that the said type of firm was a labor-saving one).
The problem of unemployment affected the basic ideological matrices of self-governing socialism. We should not forget that its ideology was based on socialization which is based on work20, that is, on the fact that it can be integrated in social community only through the sphere of work. None can enjoy the benefits of socialism without work and a person may become a-social without work-biased subjectivity. The fact that aspects of labor market, which determine economic flows, also undermine socialist principle is very important here [56]. The Yugoslav communists clearly projected the necessity of overcoming wage labor. Finally, as the important Polish economist Michal Kalecki [57] reminded us, unemployment is per se a political problem, that is, the employment rate always shows political configuration of power. Consequently, higher employment rate is homologous to the power and capacity of the working class. Political economy of Yugoslav unemployment was, in that sense, an adequate expression of general contradictions in terms of “real” self-governing socialism. Not only is unemployment an economic phenomenon but also condensation of the existing social relationships. At the same time, it shows the loss of “associational power”21, that is, disempowering of the working class which is always associated with the tendencies in the labor market. In addition, recurrent unemployment, loss of self-governing power, as published by the Yugoslav scientific literature, replicates capitalism in such a way that a “degraded worker” who loses the sense of commitment turns to infinite consumption and becomes a slave of “capitalist consumption mentality” [59]. When Yugoslav researchers tried to operationalize “alienation” (as a sense of “meaninglessness,” “anomie,” “social isolation”) then they came to the conclusion that self-governing workers felt like wage earners; therefore, despite the desired projections, the wage labor was present [60].
If we understand self-management as a framework for “zero-sum game” between socialism and capitalism, then perpetuated unemployment can be viewed as a loss of socialist horizon. Due to unemployment, the Yugoslav management allowed workers to go abroad after some hesitation. In 1972, there were about million workers and their dependents in what was then West Germany; it represented 10% of the active population and “about 20 percent of those employed outside agriculture” [36], p. 199. Two-thirds of workers went abroad just after the 1965 reform [28], which shows the effects of the reform. This only completed the extroverted mode of existence of self-management socialism, that is, the structure of dependence from world-capitalism. The mentioned dependence was obvious in the situation when there was a stagnation in capitalism in the 70s and the Western European market was less and less absorbing labor from Yugoslavia. We also have to add that with perpetual unemployment the black market flourished which, together with aspects of dependence on the world labor market, inevitably indicated to the fact that there were constitutive dimensions of capitalism in self-governing Yugoslavia.
7. Conclusion
Yugoslav self-management promised idiosyncratic coordination between politico-economic actors. Self-government was determined based on the relations between the ruling communist party, capital, and labor. The goal of the self-management was to realize the dominance of labor over capital, but workers did not become “their own capitalists.” Many economists have emphasized that self-management in Yugoslavia was introduced (“imposed”) for noneconomic or ideological reasons. Simultaneously, there was hope that self-forcing mechanisms of self-management would create such a motivational structure of economic entities that would lead to adjustment of ideological and economic patterns. Strategists in the former Yugoslav order as well as many economists believed that the market, in the context of self-management and social property, was a set of neutral mechanisms that can combine ideological teleology and economic rationality. Pro-market arguments presented by Yugoslav liberal economists did not differ from the same arguments made by theorists in capitalism (e.g. Hayek regarding the information superiority of the market.) There is even a certain analogy with state socialism which aim was to govern the market; some economists thought that there was a “socialist commodity production.” Liberal economists wished self-management to be embedded in the mechanism of the market as a guarantee of different types of freedom. Communists, however, expected the market to be embedded in self-management. However, if we take a look at the collapse of self-management in Yugoslavia, as well as the “collective irrationality” of Yugoslav socialism, then it can be said that the forms of markets that existed only prepared the way for capitalism, that is, that self-managements in Yugoslavia were “capitalist roaders.” This will not after all provide general answer to the question already mentioned here as to whether market socialism is possible at all; it will only shed light on the fact that the empirical forms of the market in Yugoslavia did not prevent later capitalism. Self-management was constituted as a front against state socialism in Soviet Union and capitalism, as well (it was the so-called “third road”); consequently, the failures of self-management marked triumph of capitalism.
Yugoslav strategists did not think that capitalism was infeasible; on the contrary, they often mentioned “capital-relationship” as an existing horizon that should be overcome, but which returned to the self-governing scene as an internal danger. Capital was, in negative context, often mentioned in various forms, such as “state capital” (that is not “socially owned”), “trade and bank capital,” and sometimes even the phrase “state capitalism” was mentioned. We have to interpret this as forms of the presence of capitalism in self-management; it cannot be otherwise. Self-governing Yugoslavia was always a strong candidate for the “bearer” of the phenomenon of capitalism due to its market orientation, which had strong deregulatory aspects. We could say that capitalism existed in self-governing socialism as a futur antérieur.
\n',keywords:"self-management, Yugoslavia, socialism, capitalism, market",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/73306.pdf",chapterXML:"https://mts.intechopen.com/source/xml/73306.xml",downloadPdfUrl:"/chapter/pdf-download/73306",previewPdfUrl:"/chapter/pdf-preview/73306",totalDownloads:423,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:51,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"June 13th 2020",dateReviewed:"August 21st 2020",datePrePublished:"September 24th 2020",datePublished:"July 7th 2021",dateFinished:"September 23rd 2020",readingETA:"0",abstract:"This chapter analyzes self-governing Yugoslavia in the context of capitalism. Regarding the problem of capitalism in socialist world, the practice of the former Yugoslavia cannot be ignored. The socialist Yugoslavia was predetermined to be qualified as capitalist. The Yugoslav leadership developed: (a) self-government, (b) elements of market-biased socialism, and (c) openness to the international economy or the integration in the world market. Its economy achieved remarkable results by the mid-1960s. Some notable economists compliment the results and suggest that the model is sustainable. However, since the mid-1960s, regressive tendencies have emerged that perpetuate significant social dissatisfaction. In 1968, students protested against the state of Yugoslav socialism, believing that it had absorbed capitalism. Others felt that Yugoslav socialism had not sufficiently developed market-based socialism. There were authors that argued that Yugoslav socialism had become capitalist but without capitalist rationality. In the 1970s, the de iure existing federation became a de facto confederation with closed national economies. The chapter discusses the presence of elements of capitalism in this form of socialism based on (a) dependence on the world market, (b) banks as the institutionalization of “financial mode of capital,” and (c) the existence of perpetuated unemployment.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/73306",risUrl:"/chapter/ris/73306",book:{id:"9551",slug:"emerging-markets"},signatures:"Alpar Losoncz, Andrea Ivanišević and Mark Losoncz",authors:[{id:"320156",title:"Prof.",name:"Andrea",middleName:null,surname:"Ivanišević",fullName:"Andrea Ivanišević",slug:"andrea-ivanisevic",email:"andrea.ivanisevic@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Novi Sad",institutionURL:null,country:{name:"Serbia"}}},{id:"324136",title:"Prof.",name:"Alpar",middleName:"N",surname:"Losonc",fullName:"Alpar Losonc",slug:"alpar-losonc",email:"alpar@uns.ac.rs",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"329031",title:"Dr.",name:"Mark",middleName:null,surname:"Losoncz",fullName:"Mark Losoncz",slug:"mark-losoncz",email:"losonczmark@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Belgrade",institutionURL:null,country:{name:"Serbia"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Some conceptual clarifications",level:"1"},{id:"sec_3",title:"3. Ideological fundamentals throughout the history",level:"1"},{id:"sec_4",title:"4. World market as a generator of capitalism in self-governing socialism: dependence",level:"1"},{id:"sec_5",title:"5. Banks as the institutionalization of “financial mode of capital”",level:"1"},{id:"sec_6",title:"6. Unemployment: elements of capitalist labor market?",level:"1"},{id:"sec_7",title:"7. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Germain E. First Balance Sheet of the Yugoslav Affair June 28, 1948–June 28, 1951. Available from: https://www.marxists.org/archive/mandel/1951/07/yugoslav.htm [Accessed: 22 July 2020]'},{id:"B2",body:'van der Linden M. Western Marxism and the Soviet Union A Survey of Critical Theories and Debates, Since 1917. Boston, Leiden: Brill; 2007. p. 209'},{id:"B3",body:'Sweezy PM. Postrevolutionary-Society. New York, London: Monthly Review Press; 1980'},{id:"B4",body:'Lohoff E. Der dritte Weg in den Bürgerkrieg – Jugoslawien und das Ende der nachholenden Modernisierung. Bad Honeff: Horlemann-Verlag; 1996. p. 47'},{id:"B5",body:'Block FL. Capitalism: The Future of an Illusion. Oakland, CA: University of California Press; 2018'},{id:"B6",body:'Vrousalis N. Exploitation as domination. Southern Journal of Philosophy. 2017;54:527-538'},{id:"B7",body:'Milios J. The Origins of Capitalism as Social System. London: Routledge; 2018. p. 4'},{id:"B8",body:'Kardelj E. Samoupravljanje u Jugoslaviji 1950-1976 (Self-management in Yugoslavia 1950-1976). Beograd: Privredni pregled; 1976. p. 24'},{id:"B9",body:'Karl M. Capital. Vol. 3. Harmondsworth: Penguin Books; (1894); 1981. pp. 571-572'},{id:"B10",body:'Jossa B. On producer cooperatives and socialism. International Critical Thought. 2014;4(3):289-303'},{id:"B11",body:'Bockman J. Markets in the Name of Socialism: The Left-Wing Origins of Neoliberalism. Stanford: Stanford University Press; 2011'},{id:"B12",body:'Bockman J. The long road to 1989, neoclassical economics, alternative socialisms, and the advent of neoliberalism. Radical History Review. 2012;(112):9-42'},{id:"B13",body:'Milton F. Neo-liberalism and its prospects. Farmand. 1951;17:89-93'},{id:"B14",body:'Avner B-N. The life-cycle of worker-owned firms in market economies: A theoretical analysis. Journal of Economic Behavior and Organization. 1988;10(3):287-313'},{id:"B15",body:'Autogestion, L’Encyclopédie internationale (without editors). 2016. Available from: https://www.syllepse.net/syllepse_images/table-des-matie--res.pdf [Accessed: 27 July 2020]'},{id:"B16",body:'Maksimović I. Osnove i razvoj socijalističkog samoupravnog sistema privređivanja (Basis and development of self-management system of economising). In: Jurin S, editor. Politička ekonomija (Political Economy). Beograd: Naučna knjiga; 1976. p. 623'},{id:"B17",body:'Horvat B. Politička ekonomija socijalizma (Political Economy of Socialism). Zagreb: Globus; 1984'},{id:"B18",body:'Bernard S. The Economics of Contracts. Cambridge, MA and London: MIT Press; 1997'},{id:"B19",body:'Horvat B. An essay on Yugoslav Society. White Plains, NY: International Arts and Sciences Press; 1969'},{id:"B20",body:'Horvat. Poduzetništvo s društvenim kapitalom (Enterpreneurship with social capital). Naše teme. 1989;11:2830'},{id:"B21",body:'Bajt A. Društvena svojina-kolektivna i individualna (Social ownership-collective and individual). Gledišta. 1968;XIX:531-544'},{id:"B22",body:'Bajt A. Social Ownership – Collective and Individual. In: Horvat B, Marković M, Kramer H, editors. Self-Governing Socialism, Vol. 2, Sociology and Politics Economics. White Plains, New York: International Arts and Sciences Press; 1975. pp. 151-164'},{id:"B23",body:'Ness I, Azzelini D, editors. Ours to Master and to Own. Chicago: Haymarket Books; 2011'},{id:"B24",body:'Jossa B. The key contradiction in capitalist system. Review of Radical Political Economics. 2014;46(3):277-291'},{id:"B25",body:'Duan Z. Market socialists’ three false propositions. Critique. 2003;31(1):131-144'},{id:"B26",body:'Samary C. Le marché contre l’autogestion: l’expérience yougoslave. Paris: Publisud, Montreuil; 1988'},{id:"B27",body:'Samary C. Le statut autogestionnaire des producteurs citoyens. In: Y a-t-il une vie apres le capitalisme (sous la direction de S. Kouvelakis). Paris: Le Temps des Cerises; 2008. pp. 65-89'},{id:"B28",body:'Sekulić D. Društveno-ekonomske reforme u jugoslovenskom društvu s osvrtom na društva “realnog socijalizma”. In: Golubović Z, editor. Teorija i praksa “realnog” socijalizma. Belgrade: Filip Višnjić; 1987'},{id:"B29",body:'Statistical Yearbook of Yugoslavia. Belgrade: Federal Statistical Office; 1971 and 1978'},{id:"B30",body:'Sanchez-Sibony O. Red Globalization: The Political Economy of the Soviet Cold War from Stalin to Khrushchev. Cambridge: Cambridge University Press; 2014'},{id:"B31",body:'Robertson JM. The socialist world in the second age of globalization: An alternative history? Markets, Globalization & Development Review. 2018;3(2):5. DOI: 10.23860/MGDR-2018-03-02-05'},{id:"B32",body:'Robertson JM. Navigating the postwar liberal order: Autonomy, creativity and modernism in socialist Yugoslavia, 1949-1953. Modern Intellectual History. 2018;17(2):385-412'},{id:"B33",body:'Woodward S. Socialist Unemployment: The Political Economy of Yugoslavia, 1945-1990. Princeton University Press: Princeton; 1995'},{id:"B34",body:'Latifić I. JUGOSLAVIJA, 1945-1990, razvoj privrede i društvenih delatnosti (Yugoslavia, 1945-1990. development of economy and social domains). Beograd: Društvo za istinu o antifašističkoj narodno oslobodilačkoj borbi u Jugoslaviji (1941-1945); 1997'},{id:"B35",body:'ten Brink T. Global Political Economy and the Modern State System. Leiden: Brill; 2014. p. 134'},{id:"B36",body:'Sirc LJ. The Yugoslav Economy under Self-Management. London: Macmillan; 1979'},{id:"B37",body:'Gligorov V. Jugoslavija i razvoj. In: Jugoslavija u istorijskoj perspektivi (Yugoslavia in Historical Perspective). Beograd: Helsinški odbor za ljudska prava; 2007. p. 401'},{id:"B38",body:'Adamović Lj S. The foreign trade system of Yugoslavia. Eastern European Economics. 1982;20(3-4):144-165'},{id:"B39",body:'Buckley B. Joint ventures in Yugoslavia: Opportunities and constraints. Journal of International Business Studies. 1985;16(1):115'},{id:"B40",body:'Suvin D. Samo jednom se ljubi. Beograd: Rosa-Luxembourg Foundation; 2014'},{id:"B41",body:'Li M. Barbarism or socialism: 1917-2017-2050 (?). Agrarian South: Journal of Political Economy. 2017;6(2):263-286'},{id:"B42",body:'Rusinow D. The Yugoslav Experiment. Berkeley: University of California Press; 1977'},{id:"B43",body:'Comisso E. Yugoslavia in the 1970’s: Self-management and bargaining. Journal of Comparative Economics. 1980;4:192-208'},{id:"B44",body:'Bajt A. Alternativna ekonomska politika (Alternative Economic Politics). Zagreb: Globus; 1985. p. 30'},{id:"B45",body:'Scott AN. Marx and disequilibrium in market socialist relations of production. Economics and Philosophy. 1987;3:23'},{id:"B46",body:'Schweickart D. Market socialist capitalist roaders: A comment on Arnold. Economics and Philosophy. 1987;3(2):308-319'},{id:"B47",body:'Perišin I. Novac, kredit i bankarstvo u sistemu samoupravljanja. Informator: Zagreb; 1975'},{id:"B48",body:'Gedeon S. Money and banking in Yugoslavia. Review of Radical Political Economics. 1985;17(1&2):41-58'},{id:"B49",body:'Gnjatović D. The Role of Foreign Funds in the Economic Development of Yugoslavia. Belgrade: Faculty of Economics; 1985. p. 129'},{id:"B50",body:'Flaherty D. Plan, market and unequal regional development in Yugoslavia. Soviet Studies. 1988;XL(1):100-124'},{id:"B51",body:'Saul E. Self-Management: Economic Theory and Yugoslav Practice. Cambridge: Cambridge University Press; 1983'},{id:"B52",body:'Elson D. Market socialism or socialisation of the market? New Left Review. 1988;172:3-44'},{id:"B53",body:'Przeworski A. Could we feed everyone? The irrationality of capitalism and the infeasibility of socialism. Politics and Society. 1991;19(1):1-38'},{id:"B54",body:'Bilandžić D. Historija Socijalističke Federativne Republike Jugoslavije. Školska knjiga: Zagreb; 1985. p. 318'},{id:"B55",body:'Palloix C, Zarifian P. De la socialisation. Paris: Francois Maspero; 1981'},{id:"B56",body:'McNally D. Against the Market: Political Economy, Market Socialism and the Marxist Critique. London: Verso; 1993. pp. 170-217'},{id:"B57",body:'Kalecki M. Political aspects of full employment. The Political Quarterly. 1943;14(4):322-330. DOI: 10.1111/j.1467-923X.1943.tb01016.x'},{id:"B58",body:'Wright E. Working-class power, capitalist-class interests, and class compromise. The American Journal of Sociology. 2000;105(4):957-1002'},{id:"B59",body:'Mesić M. Rad i upravljanje (Work and Government). Zagreb: Naše teme; 1986. p. 163'},{id:"B60",body:'Rus V, Arzenšek V. Rad Kao Sudbina i Kao Sloboda (Work as Destiny and Freedom). Zagreb: SNL; 1984. p. 431'}],footnotes:[{id:"fn1",explanation:"Yet, we should note that Mandel believed all socialist countries to be capitalist."},{id:"fn2",explanation:"This term is not be equalized with “social capital” popularized by Pierre Bourdieu."},{id:"fn3",explanation:"See [9], quoted by Jossa [10]. Jossa is a rare theoretician who believes that if capital goods are not owned by capitalists the “system is non-capitalistic” because it “reverses the capital-labor” relation. He does not use the term of self-management as much as the term of cooperatives for which he claims to be a new form of “mode of production.”"},{id:"fn4",explanation:"On neoliberalism, see [13]."},{id:"fn5",explanation:"See the discussion on property rights and appropriation [21, 22, 23]."},{id:"fn6",explanation:"Jossa [24] believes that there is a question “Which is the fundamental contradiction of capitalism: the capital-labor polarity or the contrast between socialized production and private appropriation?”. Yugoslav self-management was the answer to that question."},{id:"fn7",explanation:"We are not starting an otherwise important discussion here about the motivation of introduction for self-government, and we are not arguing whether the motivation was idealistic, legitimation-based (establishing of something unique compared to state socialism), or opportunistic (transfer of responsibility to working entities), i.e. positioning the party in internal power configuration."},{id:"fn8",explanation:"For example, some theoreticians [25] reject market socialism based on that because it assumes constant preferences."},{id:"fn9",explanation:"This periodization could be referred, for example, to [26, 27]."},{id:"fn10",explanation:"For these notions but in other perspective, see [35]."},{id:"fn11",explanation:"Or not for consumption, as other real-socialist countries did; on this relationship between Yugoslavia and the other socialist countries, see [34], p. 47."},{id:"fn12",explanation:"On this, see [40], p. 123, and [32], p. 169, 170."},{id:"fn13",explanation:"There were efforts later to solve these problems with a specific system of bargaining where the firm was no longer an operating unit but a “unit of bargaining,” see [43]."},{id:"fn14",explanation:"This paper does not focus on the breakup of Yugoslavia which can be interpreted in different ways. In Yugoslavia, the debt of the country is often exaggerated because it was not more than third of the total product (see [37]) which means that interest rate did not account for high percentage of the GDP."},{id:"fn15",explanation:"For the concept of endogenous development, see [44]."},{id:"fn16",explanation:"For a detailed account, see [47]. See the analysis of Yugoslav experiment in the light of Currency-school in banking here [48]."},{id:"fn17",explanation:"Only certain market criteria because even in the 80s it was lamented that everyone should pay for housing investments; however, only small number of beneficiaries used them. Actually, there was still no market basis for the housing construction."},{id:"fn18",explanation:"It was the request of Diane Flaherty [50]."},{id:"fn19",explanation:"See [52], p. 18, quoted by Przeworski [53]."},{id:"fn20",explanation:"We use this concept here in terms of [55]. Elson [52] used the concept of socialization in different sense as a market in the public perspective."},{id:"fn21",explanation:"On “associational power,” see [58]."}],contributors:[{corresp:null,contributorFullName:"Alpar Losoncz",address:null,affiliation:'
Faculty of Technics, University of Novi Sad, Serbia
Institute for Philosophy and Social Theory, University of Belgrade, Serbia
'}],corrections:null},book:{id:"9551",type:"book",title:"Emerging Markets",subtitle:null,fullTitle:"Emerging Markets",slug:"emerging-markets",publishedDate:"July 7th 2021",bookSignature:"Vito Bobek and Chee-Heong Quah",coverURL:"https://cdn.intechopen.com/books/images_new/9551.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-435-7",printIsbn:"978-1-83968-434-0",pdfIsbn:"978-1-83968-436-4",reviewType:"peer-reviewed",numberOfWosCitations:0,isAvailableForWebshopOrdering:!0,editors:[{id:"128342",title:"Prof.",name:"Vito",middleName:null,surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"104262",title:"Dr.",name:"Chee-Heong",middleName:null,surname:"Quah",slug:"chee-heong-quah",fullName:"Chee-Heong Quah"},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"65"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"76899",type:"chapter",title:"Liberalism, the Only True Humanism",slug:"liberalism-the-only-true-humanism",totalDownloads:133,totalCrossrefCites:0,signatures:"Pascal Salin",reviewType:"peer-reviewed",authors:[{id:"322752",title:"Prof.",name:"Pascal",middleName:null,surname:"Salin",fullName:"Pascal Salin",slug:"pascal-salin"}]},{id:"74641",type:"chapter",title:"Institutions, Culture and Foreign Direct Investment in Transition Economies: Does Culture Matter and Why?",slug:"institutions-culture-and-foreign-direct-investment-in-transition-economies-does-culture-matter-and-w",totalDownloads:431,totalCrossrefCites:0,signatures:"Sabina Silajdzic and Eldin Mehic",reviewType:"peer-reviewed",authors:[{id:"233162",title:"Associate Prof.",name:"Sabina",middleName:null,surname:"Silajdzic",fullName:"Sabina Silajdzic",slug:"sabina-silajdzic"},{id:"233367",title:"Prof.",name:"Eldin",middleName:null,surname:"Mehic",fullName:"Eldin Mehic",slug:"eldin-mehic"}]},{id:"74048",type:"chapter",title:"Africa’s Journey to Industrialization",slug:"africa-s-journey-to-industrialization",totalDownloads:180,totalCrossrefCites:0,signatures:"Chimezirim Young and Ayo Oyewale",reviewType:"peer-reviewed",authors:[{id:"324795",title:"Dr.",name:"Ayo",middleName:null,surname:"Oyewale",fullName:"Ayo Oyewale",slug:"ayo-oyewale"},{id:"327385",title:"M.Sc.",name:"Chimezirim",middleName:"Charles",surname:"Young",fullName:"Chimezirim Young",slug:"chimezirim-young"}]},{id:"73879",type:"chapter",title:"Are African Stock Markets Inefficient or Adaptive? Empirical Literature",slug:"are-african-stock-markets-inefficient-or-adaptive-empirical-literature",totalDownloads:377,totalCrossrefCites:0,signatures:"Adefemi A. Obalade and Paul-Francois Muzindutsi",reviewType:"peer-reviewed",authors:[{id:"327747",title:"Prof.",name:"Paul-Francois",middleName:null,surname:"Muzindutsi",fullName:"Paul-Francois Muzindutsi",slug:"paul-francois-muzindutsi"},{id:"327794",title:"Dr.",name:"Adefemi A.",middleName:null,surname:"Obalade",fullName:"Adefemi A. Obalade",slug:"adefemi-a.-obalade"}]},{id:"73097",type:"chapter",title:"“Pandemic” in a Stateless Society",slug:"-pandemic-in-a-stateless-society",totalDownloads:357,totalCrossrefCites:0,signatures:"Chee-Heong Quah",reviewType:"peer-reviewed",authors:[{id:"104262",title:"Dr.",name:"Chee-Heong",middleName:null,surname:"Quah",fullName:"Chee-Heong Quah",slug:"chee-heong-quah"}]},{id:"76316",type:"chapter",title:"The Influence of Economic Activity of Women in Malaysia and Guatemala on National Development",slug:"the-influence-of-economic-activity-of-women-in-malaysia-and-guatemala-on-national-development",totalDownloads:332,totalCrossrefCites:0,signatures:"Verena Habrich, Vito Bobek and Tatjana Horvat",reviewType:"peer-reviewed",authors:[{id:"128342",title:"Prof.",name:"Vito",middleName:null,surname:"Bobek",fullName:"Vito Bobek",slug:"vito-bobek"},{id:"293992",title:"Dr.",name:"Tatjana",middleName:null,surname:"Horvat",fullName:"Tatjana Horvat",slug:"tatjana-horvat"},{id:"327914",title:"B.A.",name:"Verena",middleName:null,surname:"Habrich",fullName:"Verena Habrich",slug:"verena-habrich"}]},{id:"73901",type:"chapter",title:"Digital and Digitalized Economy in EMs: A Focus on Turkey",slug:"digital-and-digitalized-economy-in-ems-a-focus-on-turkey",totalDownloads:350,totalCrossrefCites:0,signatures:"Gonca Atici",reviewType:"peer-reviewed",authors:[{id:"207200",title:"Prof.",name:"Gonca",middleName:null,surname:"Atici",fullName:"Gonca Atici",slug:"gonca-atici"}]},{id:"74578",type:"chapter",title:"Rise of Hindutva Politics, Demonetisation, and Its Impact on Micro, Small and Medium Enterprises in India",slug:"rise-of-hindutva-politics-demonetisation-and-its-impact-on-micro-small-and-medium-enterprises-in-ind",totalDownloads:254,totalCrossrefCites:0,signatures:"Geeta Sinha and Bhabani Shankar Nayak",reviewType:"peer-reviewed",authors:[{id:"322322",title:"Dr.",name:"Bhabani Shankar",middleName:null,surname:"Nayak",fullName:"Bhabani Shankar Nayak",slug:"bhabani-shankar-nayak"},{id:"322323",title:"Ms.",name:"Geeta",middleName:null,surname:"Sinha",fullName:"Geeta Sinha",slug:"geeta-sinha"}]},{id:"73166",type:"chapter",title:"The Simplification of Customs Formalities: The Role of the Authorized Economic Operator (AEO) in Vietnam and in the EU",slug:"the-simplification-of-customs-formalities-the-role-of-the-authorized-economic-operator-aeo-in-vietna",totalDownloads:305,totalCrossrefCites:0,signatures:"Alessandro Torello",reviewType:"peer-reviewed",authors:[{id:"327011",title:"Ph.D. Student",name:"Alessandro",middleName:null,surname:"Torello",fullName:"Alessandro Torello",slug:"alessandro-torello"}]},{id:"76807",type:"chapter",title:"Chile in Times of Pandemic",slug:"chile-in-times-of-pandemic",totalDownloads:209,totalCrossrefCites:0,signatures:"Daniela Ramírez",reviewType:"peer-reviewed",authors:[{id:"329687",title:"Prof.",name:"Daniela",middleName:null,surname:"Ramirez",fullName:"Daniela Ramirez",slug:"daniela-ramirez"}]},{id:"73523",type:"chapter",title:"Competitive Advantages of Cross-Border M&As to Non-Location-Bound Chinese ICT Firms",slug:"competitive-advantages-of-cross-border-m-as-to-non-location-bound-chinese-ict-firms",totalDownloads:316,totalCrossrefCites:0,signatures:"Yan Chen, Fei Li, Jaime Ortiz and Wenbo Guo",reviewType:"peer-reviewed",authors:[{id:"327730",title:"Prof.",name:"Jaime",middleName:null,surname:"Ortiz",fullName:"Jaime Ortiz",slug:"jaime-ortiz"},{id:"327908",title:"Prof.",name:"Yan",middleName:null,surname:"Chen",fullName:"Yan Chen",slug:"yan-chen"},{id:"327909",title:"Dr.",name:"Fei",middleName:null,surname:"Li",fullName:"Fei Li",slug:"fei-li"},{id:"330953",title:"Dr.",name:"Wenbo",middleName:null,surname:"Guo",fullName:"Wenbo Guo",slug:"wenbo-guo"}]},{id:"73306",type:"chapter",title:"Self-Government in Yugoslavia: The Path to Capitalism?",slug:"self-government-in-yugoslavia-the-path-to-capitalism-",totalDownloads:423,totalCrossrefCites:0,signatures:"Alpar Losoncz, Andrea Ivanišević and Mark Losoncz",reviewType:"peer-reviewed",authors:[{id:"320156",title:"Prof.",name:"Andrea",middleName:null,surname:"Ivanišević",fullName:"Andrea Ivanišević",slug:"andrea-ivanisevic"},{id:"324136",title:"Prof.",name:"Alpar",middleName:"N",surname:"Losonc",fullName:"Alpar Losonc",slug:"alpar-losonc"},{id:"329031",title:"Dr.",name:"Mark",middleName:null,surname:"Losoncz",fullName:"Mark Losoncz",slug:"mark-losoncz"}]}]},relatedBooks:[{type:"book",id:"2355",title:"International Trade from Economic and Policy Perspective",subtitle:null,isOpenForSubmission:!1,hash:"8fe6804794ddc1a7f4202db20aed5985",slug:"international-trade-from-economic-and-policy-perspective",bookSignature:"Vito Bobek",coverURL:"https://cdn.intechopen.com/books/images_new/2355.jpg",editedByType:"Edited by",editors:[{id:"128342",title:"Prof.",name:"Vito",surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"38490",title:"A Survey of Effects of International Trade on Growth",slug:"a-survey-of-effects-of-international-trade-on-growth",signatures:"Maria Hamideh Ramjerdi",authors:[{id:"140299",title:"Prof.",name:"M H",middleName:null,surname:"Ramjerdi",fullName:"M H Ramjerdi",slug:"m-h-ramjerdi"}]},{id:"38483",title:"Regions as Networks: Towards a Conceptual Framework of Territorial Dynamics",slug:"regions-as-networks-towards-a-conceptual-framework-of-territorial-dynamics",signatures:"Carlos Brito and Ricardo Correia",authors:[{id:"143319",title:"PhD.",name:"Ricardo",middleName:null,surname:"Correia",fullName:"Ricardo Correia",slug:"ricardo-correia"},{id:"143325",title:"Prof.",name:"Carlos",middleName:null,surname:"Brito",fullName:"Carlos Brito",slug:"carlos-brito"}]},{id:"38484",title:"The Extent of Intra Industry Trade Between Thailand and ASEAN Economic Community (AEC)",slug:"the-extent-of-intra-industry-trade-between-thailand-and-asean-economic-community-aec-",signatures:"Sujinda Chemsripong",authors:[{id:"143385",title:"Dr.",name:"Sujinda",middleName:null,surname:"Chemsripong",fullName:"Sujinda Chemsripong",slug:"sujinda-chemsripong"}]},{id:"38481",title:"Regional Dynamics in Romanian Counties: Convergence and Trade",slug:"regional-dynamics-in-romanian-counties-convergence-and-trade",signatures:"Jesús López-Rodríguez and Cosmin Bolea-Gabriel",authors:[{id:"141386",title:"Prof.",name:"Jesús",middleName:null,surname:"López-Rodríguez",fullName:"Jesús López-Rodríguez",slug:"jesus-lopez-rodriguez"},{id:"141545",title:"Mr.",name:"Cosmin",middleName:null,surname:"Bolea Gabriel",fullName:"Cosmin Bolea Gabriel",slug:"cosmin-bolea-gabriel"}]},{id:"38488",title:"The Impact and Consequences of Tax Revenues' Components on Economic Indicators: Evidence from Panel Groups Data",slug:"the-impact-and-consequences-of-tax-revenues-components-on-economic-indicators-evidence-from-panel-gr",signatures:"Taufik Abdul Hakim and Imbarine Bujang",authors:[{id:"143713",title:"Dr.",name:"Imbarine",middleName:null,surname:"Bujang",fullName:"Imbarine Bujang",slug:"imbarine-bujang"},{id:"143844",title:"Mr.",name:"Taufik",middleName:null,surname:"Abdul Hakim",fullName:"Taufik Abdul Hakim",slug:"taufik-abdul-hakim"}]},{id:"38482",title:"A Comparative Analysis of the Economic Effects of Cross-Border Mergers and Acquisitions in European Countries",slug:"a-comparative-analysis-of-the-economic-effects-of-cross-border-mergers-and-acquisitions-in-european-",signatures:"Anita Maček",authors:[{id:"142587",title:"Dr.",name:"Anita",middleName:null,surname:"Maček",fullName:"Anita Maček",slug:"anita-macek"}]},{id:"38485",title:"Transboundary Animal Diseases and International Trade",slug:"transboundary-animal-diseases-and-international-trade",signatures:"Andrés Cartín-Rojas",authors:[{id:"139628",title:"Ms.",name:"Andrés",middleName:null,surname:"Cartín-Rojas",fullName:"Andrés Cartín-Rojas",slug:"andres-cartin-rojas"}]},{id:"38489",title:"International Trade Promotion in Southern Africa: Challenges and Lessons",slug:"international-trade-promotion-in-southern-africa-challenges-and-lessons",signatures:"Mercy Mpinganjira",authors:[{id:"140107",title:"Prof.",name:"Mercy",middleName:null,surname:"Mpinganjira",fullName:"Mercy Mpinganjira",slug:"mercy-mpinganjira"}]},{id:"38491",title:"Technical Barriers to Trade of Leather and Footwear: Impacts and Challenges Posed by International Standards, Regulations and Market Requirements in Brazil",slug:"technical-barriers-to-trade-of-leather-and-footwear-impacts-and-challenges-posed-by-international-st",signatures:"Mauro Silva Ruiz, Alexandre de Oliveira e Aguiar, Pedro Luiz Cortez, Cláudia Echevenguá Teixeira and Gustavo Silveira Graudenz",authors:[{id:"141766",title:"Dr.",name:"Mauro",middleName:"Silva",surname:"Ruiz",fullName:"Mauro Ruiz",slug:"mauro-ruiz"},{id:"162299",title:"Dr.",name:"Cláudia",middleName:null,surname:"Echevenguá Teixeira",fullName:"Cláudia Echevenguá Teixeira",slug:"claudia-echevengua-teixeira"},{id:"166310",title:"Dr.",name:"Alexandre",middleName:null,surname:"de Oliveira e Aguiar",fullName:"Alexandre de Oliveira e Aguiar",slug:"alexandre-de-oliveira-e-aguiar"}]},{id:"38487",title:"A Perspective on Remanufacturing Business: Issues and Opportunities",slug:"a-perspective-on-remanufacturing-business-issues-and-opportunities",signatures:"Mosè Gallo, Elpidio Romano and Liberatina Carmela Santillo",authors:[{id:"11826",title:"Prof.",name:"Elpidio",middleName:null,surname:"Romano",fullName:"Elpidio Romano",slug:"elpidio-romano"},{id:"11827",title:"Prof.",name:"Liberatina",middleName:null,surname:"Santillo",fullName:"Liberatina Santillo",slug:"liberatina-santillo"},{id:"138996",title:"PhD.",name:"Mosè",middleName:null,surname:"Gallo",fullName:"Mosè Gallo",slug:"mose-gallo"}]},{id:"38486",title:"Optimizing Global Value Chain Activities by Diagonal Cumulation of Origin",slug:"optimizing-global-value-chain-activities-by-diagonal-cumulation-of-origin",signatures:"Romana Korez-Vide",authors:[{id:"139320",title:"Dr.",name:"Romana",middleName:null,surname:"Korez Vide",fullName:"Romana Korez Vide",slug:"romana-korez-vide"}]}]}],publishedBooks:[{type:"book",id:"10",title:"Coherence and Ultrashort Pulse Laser Emission",subtitle:null,isOpenForSubmission:!1,hash:"e1bd25a76712d1cb8792820acf2ff001",slug:"coherence-and-ultrashort-pulse-laser-emission",bookSignature:"F. J. Duarte",coverURL:"https://cdn.intechopen.com/books/images_new/10.jpg",editedByType:"Edited by",editors:[{id:"13752",title:"Dr.",name:"F. J.",surname:"Duarte",slug:"f.-j.-duarte",fullName:"F. J. Duarte"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11",title:"Multi-Robot Systems",subtitle:"Trends and Development",isOpenForSubmission:!1,hash:null,slug:"multi-robot-systems-trends-and-development",bookSignature:"Toshiyuki Yasuda",coverURL:"https://cdn.intechopen.com/books/images_new/11.jpg",editedByType:"Edited by",editors:[{id:"5669",title:"Dr.",name:"Toshiyuki",surname:"Yasuda",slug:"toshiyuki-yasuda",fullName:"Toshiyuki Yasuda"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12",title:"Numerical Simulations",subtitle:"Examples and Applications in Computational Fluid Dynamics",isOpenForSubmission:!1,hash:null,slug:"numerical-simulations-examples-and-applications-in-computational-fluid-dynamics",bookSignature:"Lutz Angermann",coverURL:"https://cdn.intechopen.com/books/images_new/12.jpg",editedByType:"Edited by",editors:[{id:"13342",title:"Prof.",name:"Lutz",surname:"Angermann",slug:"lutz-angermann",fullName:"Lutz Angermann"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"13",title:"Paths to Sustainable Energy",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"paths-to-sustainable-energy",bookSignature:"Jatin Nathwani and Artie Ng",coverURL:"https://cdn.intechopen.com/books/images_new/13.jpg",editedByType:"Edited by",editors:[{id:"13730",title:"Dr.",name:"Artie",surname:"Ng",slug:"artie-ng",fullName:"Artie Ng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"14",title:"Traveling Salesman Problem",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:null,slug:"traveling-salesman-problem-theory-and-applications",bookSignature:"Donald Davendra",coverURL:"https://cdn.intechopen.com/books/images_new/14.jpg",editedByType:"Edited by",editors:[{id:"2961",title:"Prof.",name:"Donald",surname:"Davendra",slug:"donald-davendra",fullName:"Donald Davendra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[]},onlineFirst:{chapter:{type:"chapter",id:"81876",title:"An Introduction to Chiropractic BioPhysics® (CBP®) Technique: A Full Spine Rehabilitation Approach to Reducing Spine Deformities",doi:"10.5772/intechopen.102686",slug:"an-introduction-to-chiropractic-biophysics-cbp-technique-a-full-spine-rehabilitation-approach-to-red",body:'
1. Introduction
Chiropractic Biophysics® (CBP®) technique is a full-spine and posture correcting method that incorporates engineering and mathematical principles into a unique approach in the treatment of spine disorders [1, 2, 3, 4, 5]. CBP technique is best described as a ‘structural’ rehabilitation approach as opposed to ‘functional’ rehabilitation that typically encompasses physiotherapeutic modalities, stretching and exercises to regain function. The goal in structural rehabilitation is to restore the spine alignment and posture to as near normal as possible.
CBP operates on three main premises: 1. There is a normal/ideal static spinal configuration; 2. Abnormal alterations of the spine/posture result in abnormal function disrupting homeostatic balance; 3. Altered static spine/postural alignment results in abnormal dynamics [1]. The contemporary spine literature supports all three of these premises (See Section 4). CBP technique has published research on many facets of the technique including defining what normal/ideal spine alignment is, how to measure spine alignment parameters with reliable and repeatable methods, how to correct/re-align spinal displacements, and evidence proving correcting spine and postural displacements correlates with improvements in pain, disability and quality of life (QOL) measures (These studies are detailed later).
Herein, an overview is given of the scientific approach to treating spine disorders (i.e. subluxation) by the unique approach of CBP technique. A review will be given of the historical beginnings of CBP, rotations and translations of posture, the Harrison normal spinal model, radiographic analysis, posture and spinal coupling, the CBP protocol, clinical evidence of efficacy as well as the safety of the use of X-rays (The term ‘X-rays’ imply the use of plain radiographs throughout this chapter).
2. Historical beginnings
Donald D. Harrison, who had a Master’s degree in Mechanical Engineering and a Doctorate degree in Applied Mathematics developed a devote urgency to bring contemporary science to chiropractic. In the late 1970s, Harrison was the main instructor for the chiropractic technique named ‘Pettibon.’ Dissatisfied with the failure to produce spinal correction, he often incorporated his own methods in certain cases to better attain spine and posture improvements. It was in the treatment of one particular case (circa 1980) where he discovered that the body must be treated using the principles of mathematics; the term ‘mirror image®’ adjusting he later coined to describe these new approaches [1].
A 1974 paper by Panjabi et al. describes a Cartesian coordinate system for use in the description and study of joint biomechanics (Figure 1) [6]. Harrison was the first to apply this system of analysis to upright human posture (Figures 2 and 3). Harrison began discovering the rotations and translations of human posture in 1980. During the early 1980s, the analysis system evolved to incorporate a full spine analysis of the head, rib cage and pelvis in three-dimensions. The technique methods continued to evolve with intellectual contributions from early practitioners of CBP including among others, Drs. DeGeorge, Gambale, Pope and Deed Harrison (founder’s son).
Figure 1.
A vertebra described in terms of rotations about and translations along the x, y, and z-axes on a cartesian coordinate system as proposed by Panjabi (courtesy CBP seminars).
Figure 2.
If the head, thoracic cage, and pelvis are considered rigid bodies, then the possible rotations in three-dimensions are illustrated. Flexion and extension are rotations on the x-axis, axial rotation is about the y-axis, and lateral flexion is rotation about the z-axis (courtesy CBP seminars).
Figure 3.
If the head, thoracic cage, and pelvis are considered rigid bodies, then the possible translations in three-dimensions are illustrated. Lateral translations occur along the x-axis, vertical translations occur along the y-axis, and anterior–posterior translations (protraction-retraction) occurs along the z-axis (courtesy CBP seminars).
One of the unique methods within CBP is the use of ‘extension traction’ to restore the normal cervical or lumbar lordosis (Figures 4 and 5). The first cervical extension traction was with use of an inclined bench that utilized a camlock and pulley system to hyperextend the neck by pulling on the forehead [7]. This is the traction used in the first CBP non-randomized controlled clinical trial (nRCT) that showed that no traction either by no treatment or only cervical manipulation but no traction resulted in no improved alignment, while the traction group (also receiving cervical spinal manipulation) achieved improved lordosis [7].
Further development in cervical traction involved the addition of a posterior-to-anterior (PA) pull through the mid cervical spine with simultaneous extension and distraction of the head while sitting in a chair, so-called ‘Pope’s 2-way’ traction (Figure 4) [8]. A slight modification of this traction involves the use of a chin-forehead strap to add weight directly to the patients head as an extension-compression 2-way traction (Figure 4) [9]. More recently, a cervical extension orthotic (Denneroll) has been shown to be effective at increasing cervical lordosis (Figure 4).
In the mid 1990s, Deed Harrison helped to develop precision vectors for lumbar extension traction (Figure 5), where the first nRCT showing lumbar curve restoration was published in the Archives of Physical Medicine and Rehabilitation in 2002 and concluded: “This new method of lumbar extension traction is the first nonsurgical rehabilitative procedure to show increases in lumbar lordosis in chronic LBP (low back pain) subjects with hypolordosis” [10]. A lumbar extension orthotic device by Denneroll is also used for lumbar extension traction (Figure 5).
CBP technique is one of the most scientifically based posture and spine correcting techniques. There are many randomized controlled trials (RCTs), nRCTs, and well over 100 case reports/series documenting the improvement of diverse spine deformity patterns with concomitant reduction of pain, disability and increased QOL measures [11].
3. Rotations and translations of posture
The main strength of CBP technique is its fundamental underpinnings in engineering and mathematics [1]. It is a general theorem that any object can be decomposed as a rotation, a translation and a deformation [12]. Acknowledging that deformation of living tissues occurs, as in compressing of discs, ligaments, muscles etc., we divert attention to rotations and translations of posture. The main masses of the body, namely the head, thorax and pelvis can be described in relation to the body mass below within a Cartesian coordinate system (Figures 2 and 3). That is, the head is described in relation to the thorax, the thorax in relation to the pelvis, and the pelvis in relation to the feet [1, 13].
Any rotations or translations of the body masses as seen in neutral posture via external observation or internally by X-ray is acknowledged as abnormal. Therefore, no offset of the masses equates to the normal postural alignment (i.e. un-subluxated position). It is important to note that in the assessment of a patient, it is the presence of a rotation or translation in the neutral standing position that is abnormal. When Harrison first applied this method of analysis, the treatment became apparent with the postural diagnosis. That is, for any rotation or translation apparent in neutral standing posture, the opposite position would need to be the treatment as applied during exercises, spinal traction or spinal adjustments, as this is the mathematical solution, “the exact reversing of the patient’s abnormal posture.” [1] In fact, because the soft tissues require a significant magnitude of stress and strains to attempt to correct the spinal position via mirror image methods, Harrison suggested that postural reflections (i.e. ‘mirror image’ adjustments) need to be applied in “twice the negative of the translation distances and rotation angles.” [1].
It should be noted when Harrison finally developed the full spine analysis of rotations and translations of posture in the mid 1980s, he discovered that virtually 50% of all human movements had never been studied (except forward head posture). Thus, the Harrison research group performed several studies to evaluate the normal range of motion for several translation postures including lateral head and thoracic postures as well as anterior and posterior thoracic translation postures (Discussed in Section 6). [2, 3] Clinically, the spinal coupling patterns as discovered to be associated with these common postural positions are of utmost importance in the treatment of these spinal disorders.
Importance of the study of these never previously studied translation postures can be highlighted in the distinction between true scoliosis and ‘pseudo-scoliosis’ (Figure 6) [14] Pseudo-scoliosis is a lateral thoracic translation posture that characteristically features little to no vertebral rotation (simple to correct) [15, 16], whereas, true scoliosis characteristically features significant vertebral rotation (and is typically much more difficult to treat). X-ray screening of the spine is the only way to differentiate true scoliosis from pseudo-scoliosis.
Figure 6.
Posture image and antero-posterior lumbar radiographs depicting a left lateral thoracic translation (side shift). Both patients in the radiographs have a 20 mm left lateral shift of T10 off midline. Left patient has a pure left lateral thoracic translation posture, aka ‘pseudo-scoliosis.’ Right patient has a true left lumbar scoliosis (vertebral rotation). Green line is vertical; red line highlights patient alignment (courtesy CBP seminars).
As mentioned, the absence of rotations and translations of the body masses in standing posture is normal. However, the shape of the spine position, particularly in the sagittal plane has traditionally been debated.
4. The Harrison normal spine model
In the mid 1990s to the mid 2000s, the Harrison research team performed a series of spine modeling studies of the sagittal spinal curves (Figure 7) [17, 18, 19, 20, 21, 22, 23, 24]. To this day, this seminal work serves as the treatment outcome goal (i.e. gold standard) for providing structural rehabilitation by CBP methods (Figure 8). In a series of systematic studies, elliptical shape modeling of the path of the posterior longitudinal ligament was performed as it could be easily compared to the posterior vertebral body margins on X-rays, the same anatomical region used for measuring the sagittal spinal curves (i.e. Harrison posterior tangents (Figure 9) [25, 26, 27, 28]).
Figure 7.
The Harrison normal sagittal spine model as the path of the posterior longitudinal ligament. The cervical, thoracic and lumbar curves are all portions of an elliptical curve having a unique minor-to-major axis ratio. The cervical curve is circular meaning the minor and major axes are equal (courtesy CBP seminars).
Figure 8.
Three patients demonstrating dramatically different spine alignment patterns. Left: excessive lumbar hyperlordosis, L4 anterolisthesis, and excessive anterior sagittal balance in a mid-aged female with disabling low back pain; middle: excessive thoracolumbar kyphosis and early degenerative changes in a mid-aged male; right: excessive thoracic hyperkyphosis in a young male with Scheuermann’s disease. Red line is contiguous with posterior vertebral body margins; green line represents Harrison normal spinal model (courtesy PAO).
Figure 9.
Harrison posterior tangent method involves lines drawn contiguous with the posterior vertebral body margins. Intersegmental as well as regional sagittal curves are easily quantified having a standard error of measurement within about 2° (courtesy CBP seminars).
Computer iterations of spine shape modeling were applied to determine the best-fit geometric spinal shapes by fitting ellipses of varying minor-to-major axis ratios to the digitized data points from the posterior vertebral body corners from X-ray samples for each of the three regions of the spine (cervical [17, 18, 19], thoracic [20, 21], and lumbar spine [22, 23, 24]). As shown in Figure 7, the Harrison normal spinal model features a circular cervical lordosis, an elliptical thoracic curve featuring greater curvature cephalad with a straightened thoraco-lumbar junction and an elliptical lumbar lordosis showing a greater distal lumbar curvature. The spine is assumed to be vertical in the front view.
Although some have attempted to criticize the Harrison normal spinal model, it is important to acknowledge that it has been validated in several ways. Simple analysis of alignment data on samples of normal, asymptomatic populations have been done [17, 18, 19, 20, 21, 22, 23, 24]. Comparison studies between normal samples to symptomatic samples have been performed [17, 29]. Comparisons between normal samples to theoretical ideal models have been done [17, 18, 20, 23]. Statistical differentiation of asymptomatic subjects from symptomatic pain group patients based on alignment data has been performed [19, 24].
In subsequent biomechanical modeling studies, the Harrison group used a validated postural loading model to verify that sagittal spinal balance and the sagittal curves of the spine are critical biomechanical parameters for maintaining postural load balance in healthy subjects [30]. Keller et al. [30] stated “because the pattern of [intervertebral disc] IVD postural stresses mirrored the sagittal curvatures and sagittal displacement of the spine, a failure of the IVD’s hydrostatic mechanism under these sustained loads could occur”. In a similar biomechanical modeling study, Harrison et al. determined that anterior sagittal thoracic posture (anterior thorax translation relative to the pelvis) resulted in significant increases in disc loads and stresses for all vertebral levels below T9 and that the extensor muscle loads required to maintain static equilibrium in upright anterior posture increased almost five times that of normal [31]. In another study Keller et al. [32] determined that “postural forces are responsible for initiation of osteoporotic spinal deformity in elderly subjects”.
The Harrison group also used an elliptical shell model to evaluate the loads and bending moments on the cervical vertebrae in varying cervical spine deformity alignments [33, 34]. They found that in normal lordosis the anterior and posterior vertebral body stresses are nearly uniform and minimal, whereas, in cervical deformity configurations having kyphosis (S-shape kyphosis high or low, total kyphosis), the vertebral body stresses are ‘very large’ and opposite in direction compared to normal lordosis [33]. They concluded “This analysis provides the basis for the formation of osteophytes (Wolff’s Law) on the anterior margins of vertebrae in kyphotic regions of the sagittal cervical curve. This indicates that any kyphosis is an undesirable configuration in the cervical spine” [33]. Anterior head translation and a ‘military’ neck also displayed significantly increased vertebral body stresses that are reverse in direction from C5-T1 and are also proven to be “undesirable configurations in the cervical spine” [34].
5. Radiographic analysis
All radiographs should be taken in the ‘neutral’ standing position with the feet positioned with the heels at hips width apart. This is to avoid any induced postural deviations due to foot position. Also, to ensure a reproducible neutral (i.e. natural) body position, the subject should close their eyes and nod the head back and forth a couple times to where the subject should stop in their preferred position and then open their eyes while maintaining this adopted stance. Any postural misalignments seen in the subject should not be corrected. The lower body mass on the particular view being taken should be centered to the bucky. All X-rays should be taken without footwear.
It should be mentioned that the measurement of different sagittal spinal contours including regional curves or absolute rotation angles (ARAs) (i.e. cervical/lumbar lordosis; thoracic kyphosis) and intersegmental relative rotation angles (RRAs) between adjacent vertebrae can be easily quantified by use of the Harrison posterior tangent (HPT) lines (Figure 9) [25, 26, 27, 28]. The HPT method is preferred for three main reasons, 1. The posterior margins of the vertebral bodies are less affected by osteoarthritic changes as compared to the anterior margins which makes anatomical measurements more reliable and valid; 2. The posterior tangents are contiguous with the slope of the spinal curves and represent the first derivative in an engineering analysis and therefore, their intersection accurately depicts the sagittal configuration; 3. The HPT method has a small standard error of measurement (SEM) of approximately 2° versus higher SEMs with the Cobb (4.5–10°) [25, 26, 27]. This is why the HPT method is superior to other methods of sagittal spine mensuration including the popular Cobb method.
Generally, the global curves are measured as C2-C7, T1-T12, and L1-L5, however since the inflection of the cervical lordosis to thoracic kyphosis occurs at T1, some clinicians prefer to measure the cervical curve from C1-T1, and the thoracic curve from T2-T11 or T3-T10. Anterior sagittal translation distances are simply measured by the horizontal displacement offset between comparison vertebrae such as C2-S1, C2-C7 or T1, T1-T12, etc.
The anterior-to-posterior (AP) or PA X-rays are taken using the same postural positioning. The modified Risser-Ferguson method is employed to measure coronal plane alignment (Figure 10) [28]. On the AP/PA cervicothoracic view an upper angle is created as the angle between the best fit line of the upper cervical segments and intersection with the bite line, and a lower angle is formed between the best fit lines of the upper to lower spine segments [28]. The Rz angle is the angle formed by a vertical axis line (VAL) drawn from T4 and the lower cervicothoracic best fit line. Normal upper angle, lower angle and Rz cervicothoracic angles are 90°, 0° and 0°, respectively. The AP/PA thoracic view may show an angle. The lumbo-pelvic view has an upper angle, the angle between the best fit line of the upper versus lower lumbar segments, and a lower angle, the angle between the best fit line between the lower segments and the horizontal pelvic line [28]. The upper angle and lower angle should be 0° and 90°, respectively. Any regional or full-spine coronal balance offset (i.e. imbalance) can be easily quantified as the horizontal distance between the uppermost segment to the lowermost segment (e.g. C2-T2, T1-T12, T12-S1, C2-S1).
Figure 10.
AP radiographic line drawing by modified Risser-Ferguson method.
6. Posture and spinal coupling
Postural rotations and translations as described by Harrison (Figures 2 and 3) are understood as ‘main motions’ and the corresponding spinal displacements to accommodate the postural positions are termed ‘coupled motions’ [2, 3, 35, 36, 37, 38]. In CBP, a considerable clinical significance is placed on the correlation between the patient’s three-dimensional postural presentation (posture displacement in terms of rotations and translations) and the two-dimensional X-ray coupled motion (spinal rotations and translations) [2, 3, 38].
Of prime importance is the appreciation that unless there is buckling, anomalies or ligament damage, standing neutral postural rotation and translation displacements of the head or thorax cause the vertebral spinal coupling patterns as seen on X-ray. If a patient’s rotations and/or translations of posture ‘match’ the associated spinal coupling pattern as expected (i.e. normal coupling), then it is considered an ‘easy’ or typical case and the intuitive mirror image application of CBP methods would apply. When the patient’s rotations and/or translations of posture do not match the expected spine coupling pattern (i.e. spinal coupling does not match postural displacement), then it is considered an atypical case where the clinician needs to consider alternative (i.e. more complicated) strategies for spine rehabilitation.
A classic demonstration of the ‘matching’ versus ‘mismatching’ of rotations and translations of posture and spine coupling patterns can be illustrated with forward head posture, aka, anterior head translation (AHT) (Figure 11). The natural and expected spine coupling with a forward translated head posture involves lower cervical spine flexion and upper cervical spine extension. As seen in Figure 11, many spine different vertebral coupling patterns are possible including hyperlordosis, hypolordosis, or kyphosis and accordingly, each cervical configuration requires its own unique application of CBP methods for its ideal correction.
Figure 11.
Forward head translation as shown in posture and in three unique lateral cervical radiographs. All three X-ray images have about 25 mm of forward head translation. Left: hyperlordosis; middle: hypolordosis; right: kyphosis. Green line is normal alignment; red line highlights patient alignment.
These cervical spine patterns have been termed harmonics and their presence can only be determined by radiography [2, 39]. Importantly, in CBP treatment approaches, each cervical spine coupling pattern (harmonic) requires its own unique treatment protocol. This is why many manual therapy approaches (e.g. Mackenzie head retractions) are inadequate at correcting posture and spine alignment as these are prescribed universally (i.e. ‘blackbox treatment’) resulting in many patients receiving treatment protocols that are contraindicated. A patient with a hyperlordotic cervical spine should never be prescribed neck extension exercises as this would dynamically hyperextend the cervical joints. A patient with a complete cervical kyphosis should never be prescribed head retraction exercises as this often ‘buckles’ the spine into further kyphosis.
Also, as mentioned and illustrated in Figure 6, ‘pseudo-scoliosis’ or pure lateral translations of the thorax (or head) must be distinguished from true scoliosis by examination of the spinal coupling patterns [14]. If there is minimal or no vertebral rotation then this represents a typical case requiring CBP mirror image postural correction [3]. If there is vertebral rotation then it is considered true scoliosis and a completely different application of CBP methods (i.e. non-commutative properties of finite rotation angles [40, 41]). Case examples of the special application of CBP methods in the treatment of scoliosis is described later.
7. CBP protocol
The CBP patient management protocol [2, 3, 4] involves all typical initial patient examination procedures including the consultation, examination as well as pain, disability and quality of life questionnaires (Figure 12). In addition, CBP treatment consideration requires, without exception, a full-spine posture assessment as well as full-spine AP and lateral standing radiographs. Posture needs to be either qualitatively, but ideally quantitatively assessed as rotations and translations of the head, thorax and pelvis in three-dimensions (Figures 2 and 3). The X-rays need to be digitized and quantified, ideally with the Harrison posterior tangent method for the sagittal images and with the modified Risser-Ferguson on the AP images.
Figure 12.
CBP protocol treatment algorithm.
As seen in Figure 12, if appropriate, a new patient should be treated for their acute pain that is distinct and separate from CBP methods. It is recommended that the acute ‘pain care’ treatment include spinal manipulation, stretching (e.g. proprioceptive neuromuscular facilitation (PNF), Yoga, etc.), heat/ice, soft tissue myofascial therapy (e.g. transverse friction, Nimmo-receptor tonus technique, etc.). Once the patient experiences some initial pain relief (e.g. 6–12 treatments) they can be re-assessed and graduated to CBP structural rehabilitation. The decision to first treat a new patient with ‘acute’ pain care is a clinical decision that is mainly for patients that have either never seen a chiropractor previously or they have not been previously treated for their acute condition. For patients who have received recent previous treatment without relief, CBP rehabilitation care is recommended from the start of treatment [2, 3, 4].
CBP structural rehabilitation is suggested as either three times per week for 12-weeks (36 treatments) or four times per week for 9-weeks (36 treatments), however, the controlled trial data support treatment blocks of 30–40 treatment sessions [7, 8, 9, 10, 15, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55]. An initial patient who has acute or chronic pains and who has not been treated recently or at all for their current spine issue should be treated for an initial 6–12 sessions to provide pain relief. After signs of relief have occurred, a progress exam should be performed and the patient should be transitioned or ‘graduated’ to CBP corrective care.
CBP treatment occurs in ‘blocks of care.’ Numerous CBP controlled clinical trials (RCTs [43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55] and nRCTs [7, 8, 9, 10, 15, 42]) provide evidence for spine altering changes to occur in the range of 30–40 treatment sessions; thus, it is the practitioners’ choice to set their protocol within this range (i.e. treatment blocks). The end of each ‘block’ of CBP care requires a progress exam which includes all of the typical assessment procedures as well as a posture and X-ray assessment. Exam results may either dictate the need for further CBP treatment or the recommendation for ‘supportive’ or maintenance care. An initial block of CBP structural rehabilitation will include any acute care provided in the first 2–4 weeks. It is always recommended that ongoing ‘progress exams’ be performed regularly, at either 4-week or 12 treatment intervals, or as frequently as recommended by each practitioner’s regional regulatory board requirements.
CBP does not specifically support ‘long-term’ care plans. However, based on the data, an adult typically needs 6-months of corrective care (e.g. 72 treatments over 6-months at 3x/week) which is an evidence-based recommendation. Although, any given patient may require a shorted (i.e. 3-month) or longer treatment program based on their initial presenting postural parameters—approximate treatment extrapolations can be made by studying Tables 1–3. There is also support for supportive/maintenance care at a frequency of approximately 2×/month [8, 9, 10].
Study
Journal
Traction method
Traction time
Number of treatments
Change (*)
Change/txt (*)
Theoretical treatment extrapolation
Hypolordotic -20°
No curve 0°
Kyphotic +20°
RCTs
Moustafa
Sci Reports
Denneroll
20m
30
13.9
0.46
32
76
119
Moustafa
Heliyon
Denneroll
15–20m
30
13.4
0.45
34
78
123
Moustafa
J Athl Train
Denneroll
20m
30
14.7
0.49
31
71
112
Moustafa
APMR
Denneroll
20m
30
13.1
0.44
34
80
126
Moustafa
EJPRM
Denneroll
20m
30
13.7
0.46
33
77
120
Moustafa
BFPTCU
Denneroll
20m
36
12.8
0.36
42
98
155
nRCTs
Harrison
JMPT
Pope 2-way
20m
38
17.9
0.47
32
74
117
Harrison
APMR
2way
20m
35
14.2
0.41
37
86
136
Harrison
JMPT
Ext-comp
10m
60
13.2
022
68
159
250
Table 1.
Summary of cervical lordosis improvement by number of treatments, magnitude correction/treatment and the extrapolation to typical sagittal cervical curve subluxation types and the theoretical treatment number required for their correction to -35° C2-7 ARA.
*Note: Correction is estimated to achieve -35 of cervical lordosis.
Study
Journal
Traction method
Traction time
Number of treatments
Change (*)
Change/ txt (*)
Theoretical treatment extrapolation
Hypolordotic -30°
Hypolordotic -15°
No curve 0°
RCTs
Moustafa
JBMR/JMPT
LET
20m
30
6.2
0.21
48
121
194
Moustafa
Clin Rehab
LET
20m
30
8.7
0.29
34
86
138
nRCTs
Harrison
APMR
LET
20m
36
11.3
0.31
32
80
127
Table 2.
Summary of lumbar lordosis improvement by number of treatments, magnitude correction/treatment and the extrapolation to typical sagittal lumbar curve subluxation types and the theoretical treatment number required for their correction to -40° L1-5 ARA.
*Note: Correction is estimated to achieve -40 of lumbar lordosis.
Study
Journal
Traction method
Traction time
Number of treatments
Change (mm)
Change/txt (mm)
Theoretical treatment extrapolation
Mild offset ±10mm
Moderate offset ±20mm
Severe offset ±30mm
nRCTs
Head trans Harrison
JRRD
Lat trans
20 m
37
6.9
0.19
54
107
161
Thorax trans Harrison
Eur Sp J
Lat trans
20 m
36
7.7
0.21
47
94
140
Table 3.
Summary of AP head and thorax lateral translation reduction by number of treatments, magnitude correction/treatment and the extrapolation to larger coronal plane offset subluxations and the theoretical treatment number required for their correction.
Note: Correction is estimated to achieve 0mm of offset.
8. Clinical evidence of efficacy
As mentioned, CBP technique has an abundance of clinical evidence supporting its effectiveness in correcting spine deformity and posture [7, 8, 9, 10, 15, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55]. Recently, systematic reviews have summarized the clinical evidence as reported in the published controlled trials on these methods [56, 57]. We summarize the evidence here in four parts: cervical lordosis, lumbar lordosis, lateral translation (pseudo-scoliosis) postures of the head and thorax, and finally, evolving evidence from case reports/series on other important spine deformities including lumbar spondylolisthesis, cervical spondylolisthesis, thoracic hyperkyphosis, thoraco-lumbar junctional kyphosis, thoracic hypokyphosis (straight back syndrome), anterior sagittal balance, lumbar kyphosis (flat back syndrome), lumbar hyperlordosis, post-surgical cervical spine fusion and scoliosis.
8.1 Cervical lordosis
A recent systematic review found that of the RCTs and nRCTs on CBP extension traction methods, a 12–18° improvement in cervical lordosis can be achieved in 10–15 weeks after 30–36 treatment sessions [57]. Most RCTs have used the cervical Denneroll [43, 44, 45, 46, 47, 49, 50], and the three nRCTs all used different CET methods (Table 1) [7, 8, 9].
Table 1 shows the improvement in degrees per treatment as well as theoretical numbers of treatments for various presenting cervical spine subluxations. On average, there appears to be just less than a half degree improvement per treatment session; obviously, there are patients that will have both more correction and less correction than this. Using this estimation as an initial guideline, evidence-based treatment numbers can be predicted. For example, a patient presenting with a cervical kyphosis of 20° would require over 100 treatments to restore the neck to a curve of 35°.
Figures 13 and 14 show the long-term outcomes in patients receiving cervical extension traction versus comparative groups not receiving the traction. The patients restoring lordosis via CBP traction methods show improved cervical alignment which is maintained at a years’ follow-up (Figure 13) whereas, comparative groups receiving various physiotherapeutic treatments less the extension traction do not experience cervical improvement (Figure 13) and also show that any initial pain relief regresses back towards baseline levels after the cessation of treatment (Figure 14). Patient’s with improved lordosis retain their initial pain relief a year later (Figure 14). This is alarming as it shows patients receiving various physiotherapeutic treatments who do not improve their cervical lordosis (in hypolordotic patients) will have a future regression of symptoms post-treatment and may be misled by ‘apparent treatment efficacy’ [5, 57].
Figure 13.
Data from five RCTs demonstrates patients achieving cervical lordosis improvement (via extension traction) as well as conventional treatments have lordosis improvements that are sustained for 1 year after stopping treatment versus the cervical curve of comparative groups (controls not achieving lordosis improvement) remain unaffected by conventional treatments (weighted averages from five RCTs [44, 45, 47, 49, 50]). * indicates a significant group difference as specified in each of the five trials; brackets represent weighted standard deviation.
Figure 14.
Data from five RCTs demonstrates patients achieving cervical lordosis improvement (via extension traction) as well as conventional treatments have pain reductions that are sustained for 1 year after stopping treatment versus comparative groups (controls not achieving lordosis improvement) who show a regression (increase) of pain intensity towards baseline after stopping treatment (weighted averages from five RCTs [45, 46, 47, 49, 50]). * indicates a significant group difference as specified in each of the five trials; brackets represent weighted standard deviation.
8.2 Lumbar lordosis
A recent systematic review found “Limited but good quality evidence substantiates that the use of extension traction methods in rehabilitation programs definitively increases lumbar hypolordosis” [56]. The authors further stated: “Preliminarily, these studies indicate these methods provide longer-term relief to patients with low back disorders versus conventional rehabilitation approaches tested” [56]. On average, a 7–11° increase in lordosis can be achieved over 10–12 weeks after 30–36 treatment sessions (Table 2).
It must be mentioned that lumbar extension traction is necessary to increase the lumbar lordosis. Importantly, using the data from published trials [10, 53, 54, 55], one can extrapolate approximate treatment duration (Table 2). As seen, a mild hypolordotic lumbar spine of 30° (L1-L5 ARA) may only require 32–48 treatments, whereas, a flat lumbar curve would require 127–194 treatments to achieve a normal 40° lordosis.
The same trend as observed in patients receiving cervical lordosis correction versus comparative groups not receiving lordosis improvement is seen in the trials on the lumbar spine [5, 56]. Lordosis increase in patients receiving lumbar extension traction is achieved and maintained at 6-months follow-up (Figure 15); these patients also retain their initial pain relief whereas, comparative patient groups not receiving lordosis improvement (Figure 15) lose their initial pain relief by 6-months after cessation of treatment (Figure 16). Again, this is alarming and shows how active low back treatment, although offering transient pain relief, will likely regress after treatment if not receiving concurrent lordosis correction in those suffering from hypolordotic-related LBP [5, 56].
Figure 15.
Data from two RCTs demonstrates patients achieving lumbar lordosis improvement (via extension traction) as well as conventional treatments have lordosis improvements that are sustained for 6-months after stopping treatment versus the lumbar curve of comparative groups (controls not achieving lordosis improvement) remain unaffected by conventional treatments (weighted averages from two RCTs [53, 54]). * indicates a significant group difference as specified in each of the two trials; brackets represent weighted standard deviation.
Figure 16.
Data from two RCTs demonstrates patients achieving lumbar lordosis improvement (via extension traction) as well as conventional treatments have pain reductions that are sustained for 6-months after stopping treatment versus comparative groups (controls not achieving lordosis improvement) who show a regression (increase) of pain intensity towards baseline after stopping treatment (weighted averages from two RCTs [53, 54]). * indicates a significant group difference as specified in each of the two trials; brackets represent weighted standard deviation.
8.3 AP head and thorax postures
Coronal plane lateral translations of the head and thorax also referred to as ‘pseudo-scoliosis’ each has an nRCT published [15, 42] and many case reports demonstrating its reduction [16, 58, 59, 60, 61, 62, 63]. As discussed earlier, the differentiation from true scoliosis is that the involved vertebrae have minimal to no rotation, whereas, true scoliosis has substantial vertebral rotation (Figure 6). Also, the spinal coupling pattern of a laterally translated body mass (head or thorax) will demonstrate the lower involved spinal region to laterally flex towards the side of the translation and the upper involved spinal region to laterally flex back towards the vertical [35, 36].
Based on the data, a laterally translated body mass can be reduced about 7–8 mm after about 35 treatments. On average, correction of a laterally translated head or thorax can be corrected at about 0.2 mm per treatment, or about 1 mm per five treatments. Extrapolations of treatment numbers to patient subluxation presentation are shown in Table 3. From the data in each of the nRCTs, an approximate 50% reduction of the initial laterally translated head and thorax postures occurred; therefore, an average patient having an approximate 15 mm translation posture (head or rib cage) requires 6-months of corrective care (approximately 72 treatments). It must also be mentioned that many case reports have demonstrated larger lateral translation postural corrections/reductions with CBP methods in similar time frames [16, 58, 59, 60, 61, 62, 63], thus, these serve as approximate treatment extrapolations.
8.4 Other spine deformities
It is known that the science for manual therapies is lacking [64]. Therefore, lesser forms of evidence must be considered when evaluating various treatment approaches used to treat various spinal conditions by manual therapists [65, 66]; this includes treatment utilizing CBP methods. We now highlight more recent case studies and series showing structural spinal correction for a variety of relatively common disorders.
8.4.1 Lumbar spondylolisthesis
Fedorchuk et al. [67] reported on an 11 mm reduction (13.3–2.4 mm) of an L4 anterolisthesis in a 69-year old suffering from LBP and leg cramping. Pain relief was achieved after 60 treatments over 45 weeks. This was the first documented report of a reduction of a Grade 2 lumbar spondylolisthesis by CBP methods, as well as any other non-surgical method.
Oakley and Harrison reported on the reduction of multiple retrolistheses from L1-L4 ranging from 4.5 to 5.9 mm in a 32-year old male with LBP [68]. These were all reduced to within normal (<4.5 mm) after approximately 36 treatments over 14-weeks. A 13-month follow-up indicated the patient remained well and reported no back pain and the corrections had remained stable.
Fedorchuk et al. [69] reported on the reduction of L1 (−6.6 to −1.7 mm) and L2 (−6.1 to −2.0 mm) retrolistheses and an L5 anterolisthesis (+6.8 to −2.5 mm) in a 63-year old female bodybuilder with severe LBP and osteoarthritis. Thirty treatments were given over 10-weeks which resulted in normalizing all spondylolistheses as well as a dramatic reduction in pain and an ability to leg press 60 more pounds in the gym.
Fedorchuk et al. reported the complete reduction of an L3 retrolisthesis and L4 anterolisthesis after 50 treatments over a 7-month period [70]. The patient was 57-years old with severe LBP and sciatica. The L3 retrolisthesis reduced from −5.3 to −1.7 and the L4 anterolisthesis reduced from +5.4 to +1.0 mm. After treatment the patient was able to return to playing hockey and experienced full resolution of the back pain which had forced him to retire from sport. A 1-year follow-up showed the patient had remained well and maintained the corrections.
8.4.2 Cervical spondylolisthesis
Recently, Fedorchuk et al. present a case series of eight female patients with concomitant cervical hypolordosis, forward head translation and spondylolistheses [71]. All were in motor vehicle collisions, each having at least one, and at most four simultaneous cervical vertebral spondylolistheses ranging in magnitude from >2 mm up to 4.5 mm. All cases experienced a reduction in translational offset of the spondylolistheses, and increase in cervical lordosis and a decrease in forward head translation as well as an increase in spinal canal diameter at the location of the spondylolisthesis after 30 treatment sessions that included cervical extension traction over a duration of 12-weeks. On average, the spondylolistheses reduced by 2.6 mm and there was an average drop in neck disability by 30%.
In another case, Fedorchuk et al. presented a single case of a 52-year old with chronic neck pain [72]. The patient had a C4 anterolisthesis of 2.4 mm which was reduced to 0.7 mm as well as an increase in cervical lordosis and reduction in forward head translation after 30 treatments over 12-weeks. The patient reported a resolution of their neck pain and stiffness.
8.4.3 Thoracic hyperkyphosis
Thoracic hyperkyphosis is a relatively common subluxation pattern in the aging. Although there is one RCT on CBP methods showing reduction of the deformity, it is yet to be formally published [52]. A systematic review of CBP methods used to reduce thoracic hyperkyphosis was published [73] and summarized the outcomes of several case reports and series [74, 75, 76, 77, 78, 79]. In Table 2 of the Oakley and Harrison review an average 12° reduction in thoracic kyphosis occurred after 32 treatments over 14.5 weeks from a total of 17 patients [52]. The improved posture correlated with reduced pain, disability and improved QOL [52]. Figures 17 and 18 show various CBP mirror image spinal exercises and traction, respectively.
Figure 17.
CBP recommended mirror image exercises for patients with thoracic hyper-kyphosis.
Figure 18.
CBP mirror image traction for patients with thoracic hyper-kyphosis.
8.4.4 Thoracolumbar junctional kyphosis
Thoracolumbar kyphosis is the forward angled spine at the junction of the thoracic and lumbar spine and is associated with chronic LBP (CLBP). Gubbels et al. presented a case of the minimization of pain in a 16-year old female after a 22° reduction of thoracolumbar kyphosis, a 48 mm reduction of posterior sagittal balance, an 11° increase in lumbar lordosis and a 10° increase in sacral inclination [80]. Twenty-four in office treatments were given over an 8-week period with daily home traction resulting in a minimization of back pains.
8.4.5 Thoracic hypokyphosis (straight back syndrome)
Thoracic spine hypolordosis is termed straight back syndrome (SBS) and is associated with back pains and exertional dyspnea. Fortner et al. [81] reported on an 18-year old male suffering from back pains and exertional dyspnea. Twenty-four treatments over a 9-week period resulted in a 15° increase in thoracic kyphosis, a decrease in pain and improved exertional dyspnea symptoms. A 4-month follow-up showed the patient remained well.
Betz et al. [82] reported the improvement in a 19-year old male who suffered from exertional dyspnea and back pain. Over 12-weeks a 14° increase in thoracic curve was achieved resulting in relief of exertional dyspnea and pain, as well as increases in both the antero-posterior thoracic diameter and the ratio of antero-posterior to transthoracic diameter, both measures critical to the wellbeing of patients with SBS. A 2.75-year follow-up showed the patient remained well.
Fedorchuk et al. [83] reported on a 13° increased thoracic curve in a 26-year old male with back pains and type 1 diabetes. Treatment over 7-weeks included 36 sessions. Back pains reduced and importantly, there was also improvement in blood glucose immediately following the onset of each visit. An improvement in blood glucose averages, percentage of time of blood glucose in a healthy target range, and glycosylated hemoglobin occurred and the patient was able to reduce their basal insulin need by approximately half after the 7-weeks of care.
Mitchel et al. [84] reported a 10° increase in thoracic curve over 16-weeks in a 33-year old male suffering from exertional dyspnea and back pains. The measured lung capacity improved by 2L, the back pain diminished and the exertional dyspnea resolved. A 7-month follow-up indicated the patient remained well.
8.4.6 Anterior sagittal balance
Anterior sagittal balance (ASB) is the forward displacement of the upper body over the pelvis. Haas et al. reported on the dramatic 110 mm reduction in ASB in an 87-year old female with CLBP and sciatica [85]. Treatment consisted of 24 in office sessions over an 8-week period. The patient achieved a dramatic reduction of symptoms, improvements in flexibility and orthopedic testing.
Anderson et al. [86] reported on a 91 mm reduction in ASB in a 59-year old male patient suffering from a variety of symptoms associated with Parkinson’s disease. Initial treatment involved 38 treatments over 5 months. The patient experienced significant improvements in multiple postural parameters, gait, balance, hand tremors, low back and knee pains and SF-36 values. A 21-month follow-up showed the patient remained essentially well and most of the initial postural improvements were maintained.
8.4.7 Lumbar kyphosis (flat back syndrome)
Flat back syndrome (FBS) is the anterior translation of the upper body and gross loss (or kyphosis) of the lumbar spine and is associated with high pain and disability. In a case series, Harrison and Oakley describe the significant restoration of lumbar lordosis in two patients suffering from debilitating CLBP from flat back syndrome [87]. One patient had a 50° lordosis improvement in 100 treatments over 20 weeks, the other had a 26° lordosis improvement in 70 treatments over 16.5 weeks. In the discussion section of the report, it was calculated that the treatment costs of the patients receiving CBP treatment versus the projected costs for the surgical procedures recommended to the two patients equated to only 1–8%; the authors stated “at first 70 or 100 treatments may be criticized as ‘over-treatment,’ however, considering the overall cost-effectiveness and positive patient outcomes, it certainly is not” [87].
8.4.8 Lumbar hyperlordosis
Although lumbar hypolordosis is the most common lumbar misalignment in those presenting with chronic LBP [10], lumbar hyperlordosis is also seen clinically. CBP methods can be directed at decreasing lumbar lordosis and its typically associated anteriorly rotated pelvis. In a recent case, Oakley et al. [88] presented a case demonstrating the relief of CLBP and hip pains after an 8° reduction in lumbar hyperlordosis, a 5° reduction in pelvic tilt and an accompanying 17 mm reduction of forward sagittal balance. This occurred over a period of 13 months and 73 total treatments.
8.4.9 Post-surgical cervical spine fusion
Post-surgical cervical spine intervertebral fusion is not a common finding in clinical practice however, it is occasionally encountered. Many of these patients continue to suffer years after the intervention. Harrison et al. [89] presented a case showing improvement in sagittal postural parameters which corresponded with improved clinical outcome in a 52-year old male. Over a 6-month period, a 6° increase in cervical lordosis was achieved as well as a 13 mm reduction in anterior head translation (AHT). These improvements were maintained at a 2.5-year follow-up.
Fedorchuk et al. [90] also presented a successful outcome in a 43-year old with a C5-6 intersegmental fusion. After 36 treatments over 3-months, there was a 13° increase in cervical lordosis, a 9 mm decrease in AHT and a 5 mm reduction in lateral head translation.
8.4.10 Scoliosis
Although too large of a topic to address in this chapter, CBP technique has a unique approach in the treatment of scoliosis [3]. CBP methods incorporates the ‘non-commutative property of finite rotation angles under addition’ to ascertain the order of postural movements to be prescribed in the mirror image treatment of this disorder. Harrison and Oakley described reductions in curve magnitude in five lumbar or thoracolumbar scoliosis patients ranging from 5° to 24° after 18–84 treatments [40]. All patients were female and ranged in age from 19 to 45 years.
Haggard et al. reported a 19° reduction in a thoracolumbar curve in a 15-year old female patient after 24 office treatments over 15-weeks. The patient also performed 45 at home spine blocking sessions as prescribed by the attending chiropractor [41]. The patients LBP and headaches were dramatically improved, and the curve was reduced to 8°.
9. Use of X-ray
Use of X-ray for spine analysis is essential for treating spine deformities, including with CBP technique methods. Historically, there has been concerns of carcinogenicity associated with X-ray use. Recently, however, new evidence has come to light showing that anti-X-ray sentiment stemming from the supposed carcinogenicity is based on flawed science [91, 92, 93]. The bottom line is the linear no-threshold (LNT) model used to support radiation risk analysis is not scientific as it is not consistent with current radiobiological data [94, 95, 96, 97, 98].
X-rays and CT scans deliver low-dose radiation doses (<200 mGy), and because of this they cannot cause cancer. This is because low-dose (versus high-dose) radiation exposures stimulate the adaptive repair systems of the body to repair any damage done [99, 100, 101]. Although this topic is important, it is a much larger issue than the scope of this chapter but many recent reviews have found that X-rays (and CT scans) are not harmful [103]. In fact, after a substantial and critical review of higher quality studies on radiation exposure, Schultz et al. concluded: “The evidence suggests that exposure to multiple CT scans and other sources of low-dose radiation with a cumulative dose up to 100 mSv (approximately 10 scans), and possibly as high as 200 mSv (approximately 20 scans), does not increase cancer risk.” Thus, there should be no hesitation or misunderstanding surrounding X-ray risks. Doctors and patients need to become updated on X-ray safety and not succumb to the traditional carcinogenicity misinformation.
10. Conclusion
CBP technique is a well-studied approach to the structural improvement of spinal disorders. Many spinal disorders with associated pain and functional syndromes have either well characterized or evolving evidence for their treatment by the mirror image approach that underpins CBP methods. The correlation of the spine alignment and postural rotations and translations of posture are of critical importance and unique in the CBP approach.
Acknowledgments
We acknowledge the pioneering work of Dr. Donald D. Harrison.
Conflict of interest
D.E.H. teaches spine rehabilitation methods and sells products related to the treatment of spine deformities; P.A.O. is a paid consultant to CBP.
Nomenclature
AHT
anterior head translation
ASB
anterior sagittal balance
AP
anterior-to-posterior
ARA
absolute rotation angle
CBP
Chiropractic BioPhysics®
CLBP
chronic low back pain
HPT
Harrison posterior tangent
IVD
intervertebral disc
LBP
low back pain
LNT
linear no-threshold
nRCT
non-randomized controlled trial
QOL
quality of life
PA
posterior-to-anterior
PNF
proprioceptive neuromuscular facilitation
RCT
randomized controlled trial
RRA
relative rotation angle
SEM
standard error of measurement
SBS
straight back syndrome
\n',keywords:"spine deformity, structural rehabilitation, traction, exercise, chiropractic",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/81876.pdf",chapterXML:"https://mts.intechopen.com/source/xml/81876.xml",downloadPdfUrl:"/chapter/pdf-download/81876",previewPdfUrl:"/chapter/pdf-preview/81876",totalDownloads:46,totalViews:0,totalCrossrefCites:0,dateSubmitted:"October 13th 2021",dateReviewed:"January 16th 2022",datePrePublished:"May 19th 2022",datePublished:null,dateFinished:"May 19th 2022",readingETA:"0",abstract:"Chiropractic Biophysics® (CBP®) technique is a full-spine and posture correcting method that incorporates mathematical principles into a unique approach to treat spinal disorders. It considers that the identification of postural rotations and translations of human postures are first evaluated and compared to the radiographic assessment of the spine alignment. Mirror image® postural positions and movements are utilized including spinal extension positions to improve the spine and posture towards a normal/ideal alignment. Specifically, corrective exercises, corrective traction and chiropractic adjustments are performed encompassing a multimodal rehabilitation program with the goal of improving the posture and spine alignment. CBP Rehabilitation programs are typically performed in-office with supportive at-home measures. Repeat assessment including radiographs are used to quantify and monitor structural improvements. CBP technique is an evidence-based approach to treat spine deformities and is supported by all forms of clinical evidence including systematic literature reviews, randomized controlled trials, non-randomized controlled trials, case reports/series as well as is supported by biomechanical posture-spine coupling validity, radiographic and posture analysis reliability/repeatability and use of a validated biomechanical spinal model as the outcome goal of care. CBP technique is a proven method to improve pain, disability and quality of life in those with structural deformities.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/81876",risUrl:"/chapter/ris/81876",signatures:"Deed E. Harrison and Paul A. Oakley",book:{id:"11042",type:"book",title:"Complementary Therapies",subtitle:null,fullTitle:"Complementary Therapies",slug:null,publishedDate:null,bookSignature:"Prof. Mario Bernardo-Filho, Prof. Redha Taiar, Danúbia Da Cunha De Sá-Caputo and Dr. Adérito Seixas",coverURL:"https://cdn.intechopen.com/books/images_new/11042.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83969-012-9",printIsbn:"978-1-83969-011-2",pdfIsbn:"978-1-83969-013-6",isAvailableForWebshopOrdering:!0,editors:[{id:"157376",title:"Prof.",name:"Mario",middleName:null,surname:"Bernardo-Filho",slug:"mario-bernardo-filho",fullName:"Mario Bernardo-Filho"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"308067",title:"Dr.",name:"Paul A.",middleName:null,surname:"Oakley",fullName:"Paul A. Oakley",slug:"paul-a.-oakley",email:"docoakley.icc@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"308068",title:"Dr.",name:"Deed E.",middleName:null,surname:"Harrison",fullName:"Deed E. Harrison",slug:"deed-e.-harrison",email:"drdeedharrison@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Historical beginnings",level:"1"},{id:"sec_3",title:"3. Rotations and translations of posture",level:"1"},{id:"sec_4",title:"4. The Harrison normal spine model",level:"1"},{id:"sec_5",title:"5. Radiographic analysis",level:"1"},{id:"sec_6",title:"6. Posture and spinal coupling",level:"1"},{id:"sec_7",title:"7. CBP protocol",level:"1"},{id:"sec_8",title:"8. Clinical evidence of efficacy",level:"1"},{id:"sec_8_2",title:"8.1 Cervical lordosis",level:"2"},{id:"sec_9_2",title:"8.2 Lumbar lordosis",level:"2"},{id:"sec_10_2",title:"8.3 AP head and thorax postures",level:"2"},{id:"sec_11_2",title:"8.4 Other spine deformities",level:"2"},{id:"sec_11_3",title:"8.4.1 Lumbar spondylolisthesis",level:"3"},{id:"sec_12_3",title:"8.4.2 Cervical spondylolisthesis",level:"3"},{id:"sec_13_3",title:"8.4.3 Thoracic hyperkyphosis",level:"3"},{id:"sec_14_3",title:"8.4.4 Thoracolumbar junctional kyphosis",level:"3"},{id:"sec_15_3",title:"8.4.5 Thoracic hypokyphosis (straight back syndrome)",level:"3"},{id:"sec_16_3",title:"8.4.6 Anterior sagittal balance",level:"3"},{id:"sec_17_3",title:"8.4.7 Lumbar kyphosis (flat back syndrome)",level:"3"},{id:"sec_18_3",title:"8.4.8 Lumbar hyperlordosis",level:"3"},{id:"sec_19_3",title:"8.4.9 Post-surgical cervical spine fusion",level:"3"},{id:"sec_20_3",title:"8.4.10 Scoliosis",level:"3"},{id:"sec_23",title:"9. Use of X-ray",level:"1"},{id:"sec_24",title:"10. Conclusion",level:"1"},{id:"sec_25",title:"Acknowledgments",level:"1"},{id:"sec_28",title:"Conflict of interest",level:"1"},{id:"sec_27",title:"Nomenclature",level:"1"}],chapterReferences:[{id:"B1",body:'Harrison DD, Janik TJ, Harrison GR, Troyanovich S, Harrison DE, Harrison SO. Chiropractic biophysics technique: A linear algebra approach to posture in chiropractic. Journal of Manipulative and Physiological Therapeutics. 1996;19(8):525-535'},{id:"B2",body:'Harrison DE, Harrison DD, Haas JW. Structural Rehabilitation of the Cervical Spine. Evanston, WY: Harrison CBP® Seminars, Inc.; 2002'},{id:"B3",body:'Harrison DE, Betz JW, Harrison DD, et al. CBP Structural Rehabilitation of the Lumbar Spine. Eagle, ID, USA: Harrison Chiropractic Biophysics Seminars; 2007'},{id:"B4",body:'Oakley PA, Harrison DD, Harrison DE, Haas JW. Evidence-based protocol for structural rehabilitation of the spine and posture: Review of clinical biomechanics of posture (CBP) publications. Journal of the Canadian Chiropractic Association. 2005;49(4):270-296'},{id:"B5",body:'Oakley PA, Moustafa IM, Harrison DE. Restoration of Cervical and Lumbar Lordosis: CBP® Methods Overview. In: Bettany-Saltikov J, Kandasamy G, editors. Spinal Deformities in Adolescents, Adults and Older Adults [Internet]. London: IntechOpen; 2019 [cited 2022 Apr 26]. DOI: 10.5772/intechopen.90713'},{id:"B6",body:'Panjabi MM, White AA 3rd, Brand RA Jr. A note on defining body parts configurations. Journal of Biomechanics. 1974;7(4):385-387'},{id:"B7",body:'Harrison DD, Jackson BL, Troyanovich S, Robertson G, de George D, Barker WF. The efficacy of cervical extension-compression traction combined with diversified manipulation and drop table adjustments in the rehabilitation of cervical lordosis: A pilot study. Journal of Manipulative and Physiological Therapeutics. 1994;17(7):454-464'},{id:"B8",body:'Harrison DE, Cailliet R, Harrison DD, Janik TJ, Holland B. A new 3-point bending traction method for restoring cervical lordosis and cervical manipulation: A nonrandomized clinical controlled trial. Archives of Physical Medicine and Rehabilitation. 2002;83(4):447-453'},{id:"B9",body:'Harrison DE, Harrison DD, Betz JJ, Janik TJ, Holland B, Colloca CJ, et al. Increasing the cervical lordosis with chiropractic biophysics seated combined extension-compression and transverse load cervical traction with cervical manipulation: Nonrandomized clinical control trial. Journal of Manipulative and Physiological Therapeutics. 2003;26(3):139-151'},{id:"B10",body:'Harrison DE, Cailliet R, Harrison DD, Janik TJ, Holland B. Changes in sagittal lumbar configuration with a new method of extension traction: Nonrandomized clinical controlled trial. Archives of Physical Medicine and Rehabilitation. 2002;83(11):1585-1591'},{id:"B11",body:'CBP NonProfit. www.cbpnonprofit.com'},{id:"B12",body:'Beer FP, Johnston ER. Vector Mechanics for Engineers: Statics and Dynamics. 4th ed. New York: McGraw-Hill; 1984. p. 95'},{id:"B13",body:'Harrison DD. Abnormal postural permutations calculated as rotations and translations from an ideal normal upright static spine. In: Sweere J, editor. Chiropractic Family Practice. Gaitherburg, MD: Aspen Publishers; 1992'},{id:"B14",body:'Harrison DE, Betz JW, Cailliet R, Colloca CJ, Harrison DD, Haas JW, et al. Radiographic pseudoscoliosis in healthy male subjects following voluntary lateral translation (side glide) of the thoracic spine. Archives of Physical Medicine and Rehabilitation. 2006;87(1):117-122'},{id:"B15",body:'Harrison DE, Cailliet R, Betz JW, Harrison DD, Colloca CJ, Haas JW, et al. A non-randomized clinical control trial of Harrison mirror image methods for correcting trunk list (lateral translations of the thoracic cage) in patients with chronic low back pain. European Spine Journal. 2005;14(2):155-162'},{id:"B16",body:'Henshaw M, Oakley PA, Harrison DE. Correction of pseudoscoliosis (lateral thoracic translation posture) for the treatment of low back pain: A CBP® case report. Journal of Physical Therapy Science. 2018;30(9):1202-1205'},{id:"B17",body:'Harrison DD, Janik TJ, Troyanovich SJ, Holland B. Comparisons of lordotic cervical spine curvatures to a theoretical ideal model of the static sagittal cervical spine. Spine. 1996;21(6):667-675'},{id:"B18",body:'Harrison DD, Janik TJ, Troyanovich SJ, Harrison DE, Colloca CJ. Evaluations of the assumptions used to derive an ideal normal cervical spine model. Journal of Manipulative and Physiological Therapeutics. 1997;20(4):246-256'},{id:"B19",body:'Harrison DD, Harrison DE, Janik TJ, Cailliet R, Haas JW, Ferrantelli J, et al. Modeling of the sagittal cervical spine as a method to discriminate hypolordosis: Results of elliptical and circular modeling in 72 asymptomatic subjects, 52 acute neck pain subjects, and 70 chronic neck pain subjects. Spine. 2004;29:2485-2492'},{id:"B20",body:'Harrison DE, Janik TJ, Harrison DD, Cailliet R, Harmon S. Can the thoracic kyphosis be modeled with a simple geometric shape? The results of circular and elliptical modeling in 80 asymptomatic subjects. Journal of Spinal Disorders. 2002;15(3):213-220'},{id:"B21",body:'Harrison DE, Harrison DD, Janik TJ, Cailliet R, Haas JW. Do alterations in vertebral and disc dimensions affect an elliptical model of the thoracic kyphosis? Spine. 2003;28(5):463-469'},{id:"B22",body:'Troyanovich SJ, Cailliet R, Janik TJ, Harrison DD, Harrison DE. Radiographic mensuration characteristics of the sagittal lumbar spine from a normal population with a method to synthesize prior studies of lordosis. Journal of Spinal Disorders. 1997;10(5):380-386'},{id:"B23",body:'Janik TJ, Harrison DD, Cailliet R, Troyanovich SJ, Harrison DE. Can the sagittal lumbar curvature be closely approximated by an ellipse? Journal of Orthopaedic Research. 1998;16(6):766-770'},{id:"B24",body:'Harrison DD, Cailliet R, Janik TJ, Troyanovich SJ, Harrison DE, Holland B. Elliptical modeling of the sagittal lumbar lordosis and segmental rotation angles as a method to discriminate between normal and low back pain subjects. Journal of Spinal Disorders. 1998;11(5):430-439'},{id:"B25",body:'Harrison DE, Harrison DD, Cailliet R, et al. Cobb method or Harrison posterior tangent method: which to choose for lateral cervical radiographic analysis. Spine. 2000;25:2072-2078'},{id:"B26",body:'Harrison DE, Cailliet R, Harrison DD, et al. Reliability of centroid, Cobb, and Harrison posterior tangent methods: Which to choose for analysis of thoracic kyphosis. Spine. 2001;26:E227-E234'},{id:"B27",body:'Harrison DE, Harrison DD, Cailliet R, et al. Radiographic analysis of lumbar lordosis: Centroid, Cobb, TRALL, and Harrison posterior tangent methods. Spine. 2001;26:E235-E242'},{id:"B28",body:'Harrison DE, Holland B, Harrison DD, et al. Further reliability analysis of the Harrison radiographic line drawing methods: Crossed ICCs for lateral posterior tangents and AP modified-Risser Ferguson. Journal of Manipulative and Physiological Therapeutics. 2002;25:93-98'},{id:"B29",body:'McAviney J, Schulz D, Bock R, Harrison DE, Holland B. Determining the relationship between cervical lordosis and neck complaints. Journal of Manipulative and Physiological Therapeutics. 2005;28(3):187-193'},{id:"B30",body:'Keller TS, Colloca CJ, Harrison DE, Harrison DD, Janik TJ. Influence of spine morphology on intervertebral disc loads and stresses in asymptomatic adults: Implications for the ideal spine. The Spine Journal. 2005;5(3):297-309'},{id:"B31",body:'Harrison DE, Colloca CJ, Harrison DD, Janik TJ, Haas JW, Keller TS. Anterior thoracic posture increases thoracolumbar disc loading. European Spine Journal. 2005;14(3):234-242'},{id:"B32",body:'Keller TS, Harrison DE, Colloca CJ, Harrison DD, Janik TJ. Prediction of osteoporotic spinal deformity. Spine. 2003;28(5):455-462'},{id:"B33",body:'Harrison DE, Harrison DD, Janik TJ, William Jones E, Cailliet R, Normand M. Comparison of axial and flexural stresses in lordosis and three buckled configurations of the cervical spine. Clinical Biomechanics. 2001;16(4):276-284'},{id:"B34",body:'Harrison DE, Jones EW, Janik TJ, Harrison DD. Evaluation of axial and flexural stresses in the vertebral body cortex and trabecular bone in lordosis and two sagittal cervical translation configurations with an elliptical shell model. Journal of Manipulative and Physiological Therapeutics. 2002;25(6):391-401'},{id:"B35",body:'Harrison DE, Harrison DD, Cailliet R, Janik TJ, Troyanovich SJ. Cervical coupling during lateral head translations creates an S-configuration. Clinical Biomechanics (Bristol, Avon). 2000;15(6):436-440'},{id:"B36",body:'Harrison DE, Cailliet R, Harrison DD, Janik TJ, Troyanovich SJ, Coleman RR. Lumbar coupling during lateral translations of the thoracic cage relative to a fixed pelvis. Clinical Biomechanics (Bristol, Avon). 1999;14(10):704-709'},{id:"B37",body:'Harrison DE, Cailliet R, Harrison DD, Janik TJ. How do anterior/posterior translations of the thoracic cage affect the sagittal lumbar spine, pelvic tilt, and thoracic kyphosis? European Spine Journal. 2002;11(3):287-293'},{id:"B38",body:'Harrison DE, Harrison DD, Haas JW, Oakley PA. Spinal Biomechanics for Clinicians. Vol. I. Evanston, WY: Harrison Chiropractic Biophysics Seminars, Inc.; 2003'},{id:"B39",body:'Oakley PA, Cuttler JM, Harrison DE. X-ray imaging is essential for contemporary chiropractic and manual therapy spinal rehabilitation: Radiography increases benefits and reduces risks. Dose-Response. 2018;16(2):1559325818781437'},{id:"B40",body:'Harrison DE, Oakley PA. Scoliosis deformity reduction in adults: A CBP® Mirror image® case series incorporating the \'non-commutative property of finite rotation angles under addition\' in five patients with lumbar and thoraco-lumbar scoliosis. Journal of Physical Therapy Science. 2017;29(11):2044-2050'},{id:"B41",body:'Haggard JS, Haggard JB, Oakley PA, Harrison DE. Reduction of progressive thoracolumbar adolescent idiopathic scoliosis by chiropractic biophysics® (CBP®) mirror image® methods following failed traditional chiropractic treatment: A case report. Journal of Physical Therapy Science. 2017;29(11):2062-2067'},{id:"B42",body:'Harrison DE, Cailliet R, Betz J, Haas JW, Harrison DD, Janik TJ, et al. Conservative methods for reducing lateral translation postures of the head: A nonrandomized clinical control trial. Journal of Rehabilitation Research and Development. 2004;41(4):631-639'},{id:"B43",body:'Moustafa IM, Diab AA, Hegazy F, Harrison DE. Demonstration of central conduction time and neuroplastic changes after cervical lordosis rehabilitation in asymptomatic subjects: A randomized, placebo-controlled trial. Scientific Reports. 2021;11(1):15379'},{id:"B44",body:'Moustafa IM, Diab A, Shousha T, Harrison DE. Does restoration of sagittal cervical alignment improve cervicogenic headache pain and disability: A 2-year pilot randomized controlled trial. Heliyon. 2021;7(3):e06467'},{id:"B45",body:'Moustafa I, Youssef ASA, Ahbouch A, Harrison DE. Demonstration of autonomic nervous function and cervical sensorimotor control after cervical lordosis rehabilitation: A randomized controlled trial. Journal of Athletic Training. 2021;56(3):10'},{id:"B46",body:'Moustafa IM, Diab AA, Hegazy F, Harrison DE. Does improvement towards a normal cervical sagittal configuration aid in the management of cervical myofascial pain syndrome: A 1-year randomized controlled trial. BMC Musculoskeletal Disorders. 2018;19(1):396'},{id:"B47",body:'Moustafa IM, Diab AA, Harrison DE. The effect of normalizing the sagittal cervical configuration on dizziness, neck pain, and cervicocephalic kinesthetic sensibility: A 1-year randomized controlled study. European Journal of Physical and Rehabilitation Medicine. 2017;53(1):57-71'},{id:"B48",body:'Moustafa IM, Diab AAM, Hegazy FA, Harrison DE. Does rehabilitation of cervical lordosis influence sagittal cervical spine flexion extension kinematics in cervical spondylotic radiculopathy subjects? Journal of Back and Musculoskeletal Rehabilitation. 2017;30(4):937-941'},{id:"B49",body:'Moustafa IM, Diab AA, Taha S, Harrison DE. Addition of a sagittal cervical posture corrective orthotic device to a multimodal rehabilitation program improves short- and long-term outcomes in patients with discogenic cervical radiculopathy. Archives of Physical Medicine and Rehabilitation. 2016;97(12):2034-2044'},{id:"B50",body:'Moustafa IM. Does improvement towards a normal cervical configuration aid in the management of fibromyalgia. A randomized controlled trial. Bulletin of Faculty of Pharmacy, Cairo University. 2013;18(2):29-41'},{id:"B51",body:'Moustafa IM, Diab AM, Ahmed A, Harrison DE. The efficacy of cervical lordosis rehabilitation for nerve root function, pain, and segmental motion in cervical spondylotic radiculopathy. Physiotherapy. 2011;97(supplment):846-847'},{id:"B52",body:'Moustafa IM, Walton LM, Raigangir V, Shousha TM, Harrison D. Reduction of posture hyperkyphosis improves short- and long-term outcomes in patients with neck pain. Abstract: International Journal of Orthopaedic & Sports Physical Therapy. 2020;50(1):CSM143'},{id:"B53",body:'Diab AAM, Moustafa IM. The efficacy of lumbar extension traction for sagittal alignment in mechanical low back pain: A randomized trial. Journal of Back and Musculoskeletal Rehabilitation. 2013;26(2):213-220'},{id:"B54",body:'Moustafa IM, Diab AA. Extension traction treatment for patients with discogenic lumbosacral radiculopathy: A randomized controlled trial. Clinical Rehabilitation. 2012;27(1):51-62'},{id:"B55",body:'Diab AA, Moustafa IM. Lumbar lordosis rehabilitation for pain and lumbar segmental motion in chronic mechanical low back pain: A randomized trial. Journal of Manipulative and Physiological Therapeutics. 2012;35(4):246-253'},{id:"B56",body:'Oakley PA, Ehsani NN, Moustafa IM, Harrison DE. Restoring lumbar lordosis: A systematic review of controlled trials utilizing Chiropractic Bio Physics® (CBP®) non-surgical approach to increasing lumbar lordosis in the treatment of low back disorders. Journal of Physical Therapy Science. 2020;32(9):601-610'},{id:"B57",body:'Oakley PA, Ehsani NN, Moustafa IM, Harrison DE. Restoring cervical lordosis by cervical extension traction methods in the treatment of cervical spine disorders: A systematic review of controlled trials. Journal of Physical Therapy Science. 2021;33(10):784-794'},{id:"B58",body:'Haas JW, Oakley PA, Harrison DE. Cervical pseudo-scoliosis reduction and alleviation of dystonia symptoms using chiropractic BioPhysics® (CBP®) technique: A case report with a 1.5-year follow-up. The Journal of Contemporary Chiropractic. 2019;2:131-137'},{id:"B59",body:'Jaeger JO, Oakley PA, Moore RR, Ruggeroli EP, Harrison DE. Resolution of temporomandibular joint dysfunction (TMJD) by correcting a lateral head translation posture following previous failed traditional chiropractic therapy: A CBP® case report. Journal of Physical Therapy Science. 2018;30(1):103-107'},{id:"B60",body:'Oakley PA, Harrison DE. Alleviation of pain and disability in a post-surgical C4-C7 total fusion patient after reducing a lateral head translation (side shift) posture: A CBP® case report with a 14 year follow-up. Journal of Physical Therapy Science. 2018;30(7):952-957'},{id:"B61",body:'Berry RH, Oakley P, Harrison D. Alleviation of radiculopathy by structural rehabilitation of the cervical spine by correcting a lateral head translation posture (-TxH) using Berry translation traction as a part of CBP methods: A case report. The Chiropractic Journal of Australia. 2017;45(1):63-72'},{id:"B62",body:'Berry RH, Oakley PA, Harrison DE. Alleviation of chronic headaches by correcting lateral head translation posture (-TxH) using Chiropractic Biophysics & Berry Translation Traction. Annals of Vertebral Subluxation Research. 2017;(1-2):87-92'},{id:"B63",body:'Oakley PA, Berry RH, Harrison DE. A structural approach to the postsurgical laminectomy case. Journal of Vertebral Subluxation Research. 2007;(March 19):1-7'},{id:"B64",body:'Nuckols TK, Lim YW, Wynn BO, et al. Rigorous development does not ensure that guidelines are acceptable to a panel of knowledgeable providers. Journal of General Internal Medicine. 2008;23(1):37-44'},{id:"B65",body:'Rome P, Waterhouse JD. An evidence-based narrative of the evidence-base concept. Asia-Pacific Chiropractic Journal. 2020;1:004. https://doi.org/10.46323/2021004'},{id:"B66",body:'Ebrall P, Doyle M. The value of case reports as clinical evidence. The Chiropractic Journal of Australia. 2020;47(1):29-43'},{id:"B67",body:'Fedorchuk C, Lightstone DF, McRae C, Kaczor D. Correction of grade 2 spondylolisthesis following a non-surgical structural spinal rehabilitation protocol using lumbar traction: A case study and selective review of literature. Journal of Radiology Case Reports. 2017;11(5):13-26'},{id:"B68",body:'Oakley PA, Harrison DE. Correction of multilevel lumbar retrolistheses by non-surgical extension traction procedures in a patient with congenital fusion of L5-S1: A CBP® case report with a 13-month follow-up. The Journal of Contemporary Chiropractic. 2020;3(1):137-142'},{id:"B69",body:'Fedorchuk C, Haugen H. Reduction in three levels of lumbar degenerative spondylolisthesis following chiropractic care: A case report & review of the literature. Annals of Vertebral Subluxation Research. 2020;(Dec. 3):165-170'},{id:"B70",body:'Fedorchuk CA, Lightstone DF, Oakley PA, Harrison DE. Correction of a double spondylolisthesis of the lumbar spine utilizing chiropractic biophysics® technique: A case report with 1-year follow-up. Journal of Physical Therapy Science. 2021;33(1):89-93'},{id:"B71",body:'Fedorchuk C, Lightstone DF, DeVon CR, Katz E, Wilcox J. Improvements in cervical spinal canal diameter and neck disability following correction of cervical lordosis and cervical spondylolistheses using chiropractic BioPhysics technique: A case series. Journal of Radiology Case Reports. 2020;14(4):21-37'},{id:"B72",body:'Fedorchuk C, Lightstone D. Reduction in cervical anterolisthesis & pain in a 52-year-old female using chiropractic biophysics® technique: A case study and selective review of literature. Annals of Vertebral Subluxation Research. 2016;3:118-124'},{id:"B73",body:'Oakley PA, Harrison DE. Reducing thoracic Hyperkyphosis subluxation deformity: A systematic review of chiropractic BioPhysics® methods employed in its structural improvement. The Journal of Contemporary Chiropractic. 2018;1(1):59-66'},{id:"B74",body:'Fortner MO, Oakley PA, Harrison DE. Alleviation of chronic spine pain and headaches by reducing forward head posture and thoracic hyperkyphosis: A CBP® case report. Journal of Physical Therapy Science. 2018;30(8):1117-1123'},{id:"B75",body:'Oakley PA, Jaeger JO, Brown JE, Polatis TA, Clarke JG, Whittler CD, et al. The CBP® mirror image® approach to reducing thoracic hyperkyphosis: A retrospective case series of 10 patients. Journal of Physical Therapy Science. 2018;30(8):1039-1045'},{id:"B76",body:'Fortner MO, Oakley PA, Harrison DE. Treating \'slouchy\' (hyperkyphosis) posture with chiropractic biophysics®: A case report utilizing a multimodal mirror image® rehabilitation program. Journal of Physical Therapy Science. 2017;29(8):1475-1480'},{id:"B77",body:'Miller JE, Oakley PA, Levin SB, Harrison DE. Reversing thoracic hyperkyphosis: A case report featuring mirror image® thoracic extension rehabilitation. Journal of Physical Therapy Science. 2017;29(7):1264-1267'},{id:"B78",body:'Fedorchuk C, Snow E. Reduction in thoracic hyperkyphosis with increased peak expiratory flow (PEF), forced expiratory volume (FEV) and SF-36 scores following CBP protocols in asymptomatic patients: A case series. Annals of Vertebral Subluxation Research. 2017;(Oct. 12):189-200'},{id:"B79",body:'Jaeger JO, Oakley PA, Colloca CJ, et al. Non-surgical reduction of thoracic hyper-kyphosis in a 24-year old music teacher utilizing chiropractic biophysics® technique. British Journal of Medicine and Medical Research. 2016;11:1-9'},{id:"B80",body:'Gubbels CM, Werner JT, Oakley PA, Harrison DE. Reduction of thoraco-lumbar junctional kyphosis, posterior sagittal balance, and increase of lumbar lordosis and sacral inclination by chiropractic BioPhysics® methods in an adolescent with back pain: A case report. Journal of Physical Therapy Science. 2019;31(10):839-843'},{id:"B81",body:'Fortner MO, Oakley PA, Harrison DE. Chiropractic biophysics management of straight back syndrome and exertional dyspnea: A case report with follow-up. The Journal of Contemporary Chiropractic. 2019;2:115-122'},{id:"B82",body:'Betz JW, Oakley PA, Harrison DE. Relief of exertional dyspnea and spinal pains by increasing the thoracic kyphosis in straight back syndrome (thoracic hypo-kyphosis) using CBP® methods: A case report with long-term follow-up. Journal of Physical Therapy Science. 2018;30(1):185-189'},{id:"B83",body:'Fedorchuk C, Lightstone DF, Comer RD, Weiner MT, McCoy M. Improved glycosylated hemoglobin, hyperglycemia, and quality of life following thoracic hypokyphosis vertebral subluxation correction using Chiropractic BioPhysics®: A prospective case report. Journal of Diabetes & Metabolism. 2018;9(10):1-10'},{id:"B84",body:'Mitchell JR, Oakley PA, Harrison DE. Nonsurgical correction of straight back syndrome (thoracic hypokyphosis), increased lung capacity and resolution of exertional dyspnea by thoracic hyperkyphosis mirror image® traction: A CBP® case report. Journal of Physical Therapy Science. 2017;29(11):2058-2061'},{id:"B85",body:'Haas JW, Harrison DE, Oakley PA. Non-surgical reduction in anterior sagittal balance subluxation and improvement in overall posture in a geriatric suffering from low back pain and sciatica: A CBP® case report. The Journal of Contemporary Chiropractic. 2020;3(1):45-50'},{id:"B86",body:'Anderson JM, Oakley PA, Harrison DE. Improving posture to reduce the symptoms of Parkinson’s: A CBP® case report with a 21 month follow-up. Journal of Physical Therapy Science. 2019;31(2):153-158'},{id:"B87",body:'Harrison DE, Oakley PA. Non-operative correction of flat back syndrome using lumbar extension traction: A CBP® case series of two. Journal of Physical Therapy Science. 2018;30(8):1131-1137'},{id:"B88",body:'Oakley PA, Ehsani NN, Harrison DE. Non-surgical reduction of lumbar hyperlordosis, forward sagittal balance and sacral tilt to relieve low back pain by Chiropractic BioPhysics® methods: A case report. Journal of Physical Therapy Science. 2019;31(10):860-864'},{id:"B89",body:'Harrison DE, Oakley PA, Betz JW. Anterior head translation following cervical fusion-a probable cause of post-surgical pain and impairment: A CBP® case report. Journal of Physical Therapy Science. 2018;30(2):271-276'},{id:"B90",body:'Fedorchuk C, Lightstone DF, Andino H. Failed neck surgery: Improvement in neck pain, migraines, energy levels, and performance of activities of daily living following subluxation correction using Chiropractic Biophysics® Technique: A case study. Annals of Vertebral Subluxation Research. 2017;(May 18):93-100'},{id:"B91",body:'Calabrese EJ. Cancer risk assessment foundation unraveling: New historical evidence reveals that the US National Academy of Sciences (US NAS), biological effects of atomic radiation (BEAR) committee genetics panel falsified the research record to promote acceptance of the LNT. Archives of Toxicology. 2015;89(4):649-650'},{id:"B92",body:'Calabrese EJ. An abuse of risk assessment: How regulatory agencies improperly adopted LNT for cancer risk assessment. Archives of Toxicology. 2015;89(4):647-648'},{id:"B93",body:'Calabrese EJ. On the origins of the linear no-threshold (LNT) dogma by means of untruths, artful dodges and blind faith. Environmental Research. 2015;142:432-442'},{id:"B94",body:'Scott BR, Sanders CL, Mitchel REJ, Boreham DR. CT scans may reduce rather than increase risk of cancer. The Journal of the American Physicians and Surgeons. 2008;13(1):8-11'},{id:"B95",body:'Lemon JA, Phan N, Boreham DR. Single CT scan prolongs survival by extending cancer latency in Trp53 heterozygous mice. Radiation Research. 2017;188(4.2):505-511'},{id:"B96",body:'Lemon JA, Phan N, Boreham DR. Multiple CT scans extend lifespan by delaying cancer progression in cancer-prone mice. Radiation Research. 2017;188(4.2):495-504'},{id:"B97",body:'Cuttler JM. Application of low doses of ionizing radiation in medical therapies. Dose-Response. 2020;18(1):1559325819895739'},{id:"B98",body:'Calabrese EJ, Dhawan G, Kapoor R, Kozumbo WJ. Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose. Human & Experimental Toxicology. 2019;38(8):888-898'},{id:"B99",body:'Pollycove M, Feinendegen LE. Radiation-induced versus endogenous DNA damage: Possible effect of inducible protective responses in mitigating endogenous damage. Human and Experimental Toxicology. 2003;22(6):290-306'},{id:"B100",body:'Pollycove M. Radiobiological basis of low-dose irradiation in prevention and therapy of cancer. Dose-Response. 2006;5(1):26-38'},{id:"B101",body:'Feinendegen LE, Cuttler JM. Biological effects from low doses and dose rates of ionizing radiation: Science in the service of protecting humans, a synopsis. Health Physics. 2018;114(6):623-626'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Deed E. Harrison",address:null,affiliation:'
CBP NonProfit, Inc., USA
'},{corresp:"yes",contributorFullName:"Paul A. Oakley",address:"docoakley.icc@gmail.com",affiliation:'
Private Practice, Canada
'}],corrections:null},book:{id:"11042",type:"book",title:"Complementary Therapies",subtitle:null,fullTitle:"Complementary Therapies",slug:null,publishedDate:null,bookSignature:"Prof. Mario Bernardo-Filho, Prof. Redha Taiar, Danúbia Da Cunha De Sá-Caputo and Dr. Adérito Seixas",coverURL:"https://cdn.intechopen.com/books/images_new/11042.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83969-012-9",printIsbn:"978-1-83969-011-2",pdfIsbn:"978-1-83969-013-6",isAvailableForWebshopOrdering:!0,editors:[{id:"157376",title:"Prof.",name:"Mario",middleName:null,surname:"Bernardo-Filho",slug:"mario-bernardo-filho",fullName:"Mario Bernardo-Filho"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"289740",title:"M.Sc.",name:"Erika",middleName:null,surname:"Hernández-Rubio",email:"ehernandezru@ipn.mx",fullName:"Erika Hernández-Rubio",slug:"erika-hernandez-rubio",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"Instituto Politécnico Nacional",institutionURL:null,country:{name:"Mexico"}}},booksEdited:[],chaptersAuthored:[{id:"67391",title:"Mobile Distributed User Interfaces",slug:"mobile-distributed-user-interfaces",abstract:"The success of a mobile application is due to the usability that the graphical user interface provides. A feature of mobile devices is the limited space for the interaction and the deployment of the graphical user interface. For this reason, user interfaces can have different interaction modalities. However, to work with information that can be complex to display, the use of modalities may not solve this problem. A possible alternative to provide more workspace to the users is through a distributed user interface (DUI). A mobile DUI allows the mobile applications to use two or more devices to execute the user interface. These devices can be Smart TVs or wearable such as smart watches. In this work the concepts of mobile DUI design are discussed, some use cases are presented and it is shown that its development in mobile devices is feasible.",signatures:"Erika Hernández-Rubio, Amilcar Meneses-Viveros and Sonia G. Mendoza-Chapa",authors:[{id:"289740",title:"M.Sc.",name:"Erika",surname:"Hernández-Rubio",fullName:"Erika Hernández-Rubio",slug:"erika-hernandez-rubio",email:"ehernandezru@ipn.mx"},{id:"289742",title:"Dr.",name:"Amilcar",surname:"Meneses-Viveros",fullName:"Amilcar Meneses-Viveros",slug:"amilcar-meneses-viveros",email:"ameneses@cs.cinvestav.mx"},{id:"301053",title:"Dr.",name:"Sonia G.",surname:"Mendoza-Chapa",fullName:"Sonia G. Mendoza-Chapa",slug:"sonia-g.-mendoza-chapa",email:"smendoza@cs.cinvestav.mx"}],book:{id:"8678",title:"Mobile Computing",slug:"mobile-computing",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"17608",title:"Dr.",name:"Pavel",surname:"Loskot",slug:"pavel-loskot",fullName:"Pavel Loskot",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Swansea University",institutionURL:null,country:{name:"United Kingdom"}}},{id:"212143",title:"Mr.",name:"Salman",surname:"Al-Shehri",slug:"salman-al-shehri",fullName:"Salman Al-Shehri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"289742",title:"Dr.",name:"Amilcar",surname:"Meneses-Viveros",slug:"amilcar-meneses-viveros",fullName:"Amilcar Meneses-Viveros",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",institutionURL:null,country:{name:"Mexico"}}},{id:"290776",title:"Dr.",name:"José",surname:"Jailton",slug:"jose-jailton",fullName:"José Jailton",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"290799",title:"Dr.",name:"Tassio",surname:"Costa Carvalho",slug:"tassio-costa-carvalho",fullName:"Tassio Costa Carvalho",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"297181",title:"Dr.",name:"Michael J.",surname:"Hirsch",slug:"michael-j.-hirsch",fullName:"Michael J. Hirsch",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"298486",title:"BSc.",name:"Miguel Itallo B.",surname:"Azevedo",slug:"miguel-itallo-b.-azevedo",fullName:"Miguel Itallo B. Azevedo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"298488",title:"BSc.",name:"Carlos",surname:"Coutinho",slug:"carlos-coutinho",fullName:"Carlos Coutinho",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"298489",title:"BSc.",name:"Eylon Martins",surname:"Toda",slug:"eylon-martins-toda",fullName:"Eylon Martins Toda",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"301053",title:"Dr.",name:"Sonia G.",surname:"Mendoza-Chapa",slug:"sonia-g.-mendoza-chapa",fullName:"Sonia G. Mendoza-Chapa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"conflicts-of-interest-policy",title:"Conflicts of Interest Policy",intro:"
As an Open Access publisher, IntechOpen is dedicated to maintaining the highest ethical standards and principles in publishing. In addition, IntechOpen promotes the highest standards of integrity and ethical behavior in scientific research and peer-review. To maintain these principles IntechOpen has developed basic guidelines to facilitate the avoidance of Conflicts of Interest.
",metaTitle:"Conflicts of Interest Policy",metaDescription:"As an Open Access publisher, IntechOpen is dedicated to maintaining the highest ethical standards and principles in publishing. In addition, IntechOpen promotes the highest standards of integrity and ethical behavior in scientific research and peer-review.",metaKeywords:null,canonicalURL:"/page/conflicts-of-interest-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"
In each instance of a possible Conflict of Interest, IntechOpen aims to disclose the situation in as transparent a way as possible in order to allow readers to judge whether a particular potential Conflict of Interest has influenced the Work of any individual Author, Editor, or Reviewer. IntechOpen takes all possible Conflicts of Interest into account during the review process and ensures maximum transparency in implementing its policies.
\\n\\n
A Conflict of Interest is a situation in which a person's professional judgment may be influenced by a range of factors, including financial gain, material interest, or some other personal or professional interest. For IntechOpen as a publisher, it is essential that all possible Conflicts of Interest are avoided. Each contributor, whether an Author, Editor, or Reviewer, who suspects they may have a Conflict of Interest, is obliged to declare that concern in order to make the publisher and the readership aware of any potential influence on the work being undertaken.
\\n\\n
A Conflict of Interest can be identified at different phases of the publishing process.
\\n\\n
IntechOpen requires:
\\n\\n
\\n\\t
Authors to declare all relevant Conflicts of Interest that might have any bearing on research reported in their submitted manuscript.
\\n\\t
Book Editors and Reviewers to declare all possible Conflicts of Interest that might warrant their exclusion from any further handling of submissions.
\\n
\\n\\n
CONFLICT OF INTEREST - AUTHOR
\\n\\n
All Authors are obliged to declare every existing or potential Conflict of Interest, including financial or personal factors, as well as any relationship which could influence their scientific work. Authors must declare Conflicts of Interest at the time of manuscript submission, although they may exceptionally do so at any point during manuscript review. For jointly prepared manuscripts, the corresponding Author is obliged to declare potential Conflicts of Interest of any other Authors who have contributed to the manuscript.
\\n\\n
CONFLICT OF INTEREST – ACADEMIC EDITOR
\\n\\n
Editors can also have Conflicts of Interest. Editors are expected to maintain the highest standards of conduct, which are outlined in our Best Practice Guidelines (templates for Best Practice Guidelines). Among other obligations, it is essential that Editors make transparent declarations of any possible Conflicts of Interest that they might have.
\\n\\n
Avoidance Measures for Academic Editors of Conflicts of Interest:
\\n\\n
For manuscripts submitted by the Academic Editor (or a scientific advisor), an appropriate person will be appointed to handle and evaluate the manuscript. The appointed handling Editor's identity will not be disclosed to the Author in order to maintain impartiality and anonymity of the review.
\\n\\n
If a manuscript is submitted by an Author who is a member of an Academic Editor's family or is personally or professionally related to the Academic Editor in any way, either as a friend, colleague, student or mentor, the work will be handled by a different Academic Editor who is not in any way connected to the Author.
\\n\\n
CONFLICT OF INTEREST - REVIEWER
\\n\\n
All Reviewers are required to declare possible Conflicts of Interest at the beginning of the evaluation process. If a Reviewer feels he or she might have any material, financial or any other conflict of interest with regards to the manuscript being reviewed, he or she is required to declare such concern and, if necessary, request exclusion from any further involvement in the evaluation process. A Reviewer's potential Conflicts of Interest are declared in the review report and presented to the Academic Editor, who then assesses whether or not the declared potential or actual Conflicts of Interest had, or could be perceived to have had, any significant impact on the review itself.
\\n\\n
EXAMPLES OF CONFLICTS OF INTEREST:
\\n\\n
FINANCIAL AND MATERIAL
\\n\\n
\\n\\t
ownership of relevant stocks or shares;
\\n\\t
past and/or present work or consulting work for the research funder;
\\n\\t
membership of the relevant board;
\\n\\t
payment to the Reviewer/Academic Editor of financial fees by the Author;
\\n\\t
acceptance by the Reviewer/Academic Editor of gifts from the Author;
\\n\\t
other direct or indirect sources of funding or material benefit gained by the Reviewer/Academic Editor through the Author.
\\n
\\n\\n
NON-FINANCIAL
\\n\\n
\\n\\t
professional or personal relationships with institutions and funding bodies, including non-governmental organizations, research institutions and charities;
\\n\\t
membership of relevant company boards or governmental organizations;
\\n\\t
personal relationships, either through friendship, marriage, acting as a mentor, family relationships or being a student of other contributors, whether they are Authors, Reviewers or Academic Editors.
\\n
\\n\\n
Authors are required to declare all potentially relevant non-financial, financial and material Conflicts of Interest that may have had an influence on their scientific work.
\\n\\n
Academic Editors and Reviewers are required to declare any non-financial, financial and material Conflicts of Interest that could influence their fair and balanced evaluation of manuscripts. If such conflict exists with regards to a submitted manuscript, Academic Editors and Reviewers should exclude themselves from handling it.
\\n\\n
All Authors, Academic Editors, and Reviewers are required to declare all possible financial and material Conflicts of Interest in the last five years, although it is advisable to declare less recent Conflicts of Interest as well.
\\n\\n
EXAMPLES:
\\n\\n
Authors should declare if they were or they still are Academic Editors of the publications in which they wish to publish their work.
\\n\\n
Authors should declare if they are board members of an organization that could benefit financially or materially from the publication of their work.
\\n\\n
Academic Editors should declare if they were coauthors or they have worked on the research project with the Author who has submitted a manuscript.
\\n\\n
Academic Editors should declare if the Author of a submitted manuscript is affiliated with the same department, faculty, institute, or company as they are.
In each instance of a possible Conflict of Interest, IntechOpen aims to disclose the situation in as transparent a way as possible in order to allow readers to judge whether a particular potential Conflict of Interest has influenced the Work of any individual Author, Editor, or Reviewer. IntechOpen takes all possible Conflicts of Interest into account during the review process and ensures maximum transparency in implementing its policies.
\n\n
A Conflict of Interest is a situation in which a person's professional judgment may be influenced by a range of factors, including financial gain, material interest, or some other personal or professional interest. For IntechOpen as a publisher, it is essential that all possible Conflicts of Interest are avoided. Each contributor, whether an Author, Editor, or Reviewer, who suspects they may have a Conflict of Interest, is obliged to declare that concern in order to make the publisher and the readership aware of any potential influence on the work being undertaken.
\n\n
A Conflict of Interest can be identified at different phases of the publishing process.
\n\n
IntechOpen requires:
\n\n
\n\t
Authors to declare all relevant Conflicts of Interest that might have any bearing on research reported in their submitted manuscript.
\n\t
Book Editors and Reviewers to declare all possible Conflicts of Interest that might warrant their exclusion from any further handling of submissions.
\n
\n\n
CONFLICT OF INTEREST - AUTHOR
\n\n
All Authors are obliged to declare every existing or potential Conflict of Interest, including financial or personal factors, as well as any relationship which could influence their scientific work. Authors must declare Conflicts of Interest at the time of manuscript submission, although they may exceptionally do so at any point during manuscript review. For jointly prepared manuscripts, the corresponding Author is obliged to declare potential Conflicts of Interest of any other Authors who have contributed to the manuscript.
\n\n
CONFLICT OF INTEREST – ACADEMIC EDITOR
\n\n
Editors can also have Conflicts of Interest. Editors are expected to maintain the highest standards of conduct, which are outlined in our Best Practice Guidelines (templates for Best Practice Guidelines). Among other obligations, it is essential that Editors make transparent declarations of any possible Conflicts of Interest that they might have.
\n\n
Avoidance Measures for Academic Editors of Conflicts of Interest:
\n\n
For manuscripts submitted by the Academic Editor (or a scientific advisor), an appropriate person will be appointed to handle and evaluate the manuscript. The appointed handling Editor's identity will not be disclosed to the Author in order to maintain impartiality and anonymity of the review.
\n\n
If a manuscript is submitted by an Author who is a member of an Academic Editor's family or is personally or professionally related to the Academic Editor in any way, either as a friend, colleague, student or mentor, the work will be handled by a different Academic Editor who is not in any way connected to the Author.
\n\n
CONFLICT OF INTEREST - REVIEWER
\n\n
All Reviewers are required to declare possible Conflicts of Interest at the beginning of the evaluation process. If a Reviewer feels he or she might have any material, financial or any other conflict of interest with regards to the manuscript being reviewed, he or she is required to declare such concern and, if necessary, request exclusion from any further involvement in the evaluation process. A Reviewer's potential Conflicts of Interest are declared in the review report and presented to the Academic Editor, who then assesses whether or not the declared potential or actual Conflicts of Interest had, or could be perceived to have had, any significant impact on the review itself.
\n\n
EXAMPLES OF CONFLICTS OF INTEREST:
\n\n
FINANCIAL AND MATERIAL
\n\n
\n\t
ownership of relevant stocks or shares;
\n\t
past and/or present work or consulting work for the research funder;
\n\t
membership of the relevant board;
\n\t
payment to the Reviewer/Academic Editor of financial fees by the Author;
\n\t
acceptance by the Reviewer/Academic Editor of gifts from the Author;
\n\t
other direct or indirect sources of funding or material benefit gained by the Reviewer/Academic Editor through the Author.
\n
\n\n
NON-FINANCIAL
\n\n
\n\t
professional or personal relationships with institutions and funding bodies, including non-governmental organizations, research institutions and charities;
\n\t
membership of relevant company boards or governmental organizations;
\n\t
personal relationships, either through friendship, marriage, acting as a mentor, family relationships or being a student of other contributors, whether they are Authors, Reviewers or Academic Editors.
\n
\n\n
Authors are required to declare all potentially relevant non-financial, financial and material Conflicts of Interest that may have had an influence on their scientific work.
\n\n
Academic Editors and Reviewers are required to declare any non-financial, financial and material Conflicts of Interest that could influence their fair and balanced evaluation of manuscripts. If such conflict exists with regards to a submitted manuscript, Academic Editors and Reviewers should exclude themselves from handling it.
\n\n
All Authors, Academic Editors, and Reviewers are required to declare all possible financial and material Conflicts of Interest in the last five years, although it is advisable to declare less recent Conflicts of Interest as well.
\n\n
EXAMPLES:
\n\n
Authors should declare if they were or they still are Academic Editors of the publications in which they wish to publish their work.
\n\n
Authors should declare if they are board members of an organization that could benefit financially or materially from the publication of their work.
\n\n
Academic Editors should declare if they were coauthors or they have worked on the research project with the Author who has submitted a manuscript.
\n\n
Academic Editors should declare if the Author of a submitted manuscript is affiliated with the same department, faculty, institute, or company as they are.
\n\n
Policy last updated: 2016-06-09
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{id:"965887@"},profiles:[],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6601},{group:"region",caption:"Middle and South America",value:2,count:5906},{group:"region",caption:"Africa",value:3,count:2400},{group:"region",caption:"Asia",value:4,count:12541},{group:"region",caption:"Australia and Oceania",value:5,count:1008},{group:"region",caption:"Europe",value:6,count:17561}],offset:0,limit:12,total:null},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"1",sort:"dateEndThirdStepPublish",src:"ECM",topicId:"8,9,10,11,14,15,17,20,22,24"},books:[{type:"book",id:"11554",title:"Information Systems Management",subtitle:null,isOpenForSubmission:!0,hash:"3134452ff2fdec020663f241c7a9a748",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11554.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11546",title:"Smart and Sustainable Transportation",subtitle:null,isOpenForSubmission:!0,hash:"e8ea27a1ff85cde00efcb6f6968c20f8",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11546.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11834",title:"Steppe Geography",subtitle:null,isOpenForSubmission:!0,hash:"363517fa6f079daf94c51ea1b91fed2a",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11834.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11836",title:"Estuary Research",subtitle:null,isOpenForSubmission:!0,hash:"ef822fc9eee5600aeb7e45492e04a6e7",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11836.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11837",title:"The Mediterranean",subtitle:null,isOpenForSubmission:!0,hash:"bbb25987a982d61da4f47fb13614ba3c",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11837.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11846",title:"Seabed",subtitle:null,isOpenForSubmission:!0,hash:"1b1698a2d8d36b5ec3571c20486eb2c9",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11846.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11911",title:"Scientometrics",subtitle:null,isOpenForSubmission:!0,hash:"ed74b66a0dc7d009900af198efc6b2e1",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11911.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11913",title:"Scheduling Algorithms",subtitle:null,isOpenForSubmission:!0,hash:"da42ea7b678d715e23ffcae50ae47078",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11913.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11915",title:"Ontology in Computer Science",subtitle:null,isOpenForSubmission:!0,hash:"b52397215f6b5e05a22368f629695704",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11915.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11917",title:"Computational Semantics",subtitle:null,isOpenForSubmission:!0,hash:"bd9343348f2c50dbbc819a0b48a76591",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11917.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11938",title:"Ballistics",subtitle:null,isOpenForSubmission:!0,hash:"9c64ef67aac55216f08c65a2a179835c",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11938.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11941",title:"Advances in Turbomachinery",subtitle:null,isOpenForSubmission:!0,hash:"fe2c693976d70c5d0cc5f8003e6e73c5",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11941.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:41},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:12},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:17},{group:"topic",caption:"Computer and Information Science",value:9,count:16},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:17},{group:"topic",caption:"Engineering",value:11,count:32},{group:"topic",caption:"Environmental Sciences",value:12,count:7},{group:"topic",caption:"Immunology and Microbiology",value:13,count:11},{group:"topic",caption:"Materials Science",value:14,count:11},{group:"topic",caption:"Mathematics",value:15,count:6},{group:"topic",caption:"Medicine",value:16,count:106},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:7},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:11},{group:"topic",caption:"Physics",value:20,count:2},{group:"topic",caption:"Psychology",value:21,count:8},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:32},{group:"topic",caption:"Technology",value:24,count:1},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:106},popularBooks:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4387},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",publishedDate:"May 18th 2022",numberOfDownloads:3340,editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1845,editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1096,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",publishedDate:"May 18th 2022",numberOfDownloads:995,editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3791,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",publishedDate:"May 11th 2022",numberOfDownloads:2982,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",publishedDate:"May 18th 2022",numberOfDownloads:559,editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",publishedDate:"May 18th 2022",numberOfDownloads:546,editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",publishedDate:"May 18th 2022",numberOfDownloads:539,editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",publishedDate:"May 18th 2022",numberOfDownloads:535,editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"66",title:"Economic Development",slug:"economic-development",parent:{id:"7",title:"Business, Management and Economics",slug:"business-management-and-economics"},numberOfBooks:5,numberOfSeries:0,numberOfAuthorsAndEditors:89,numberOfWosCitations:7,numberOfCrossrefCitations:29,numberOfDimensionsCitations:58,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"66",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10215",title:"Circular Economy",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"161dc2ffcd5ef7e5f8144938ed7fe477",slug:"circular-economy-recent-advances-new-perspectives-and-applications",bookSignature:"Tao Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/10215.jpg",editedByType:"Edited by",editors:[{id:"185487",title:"Associate Prof.",name:"Tao",middleName:null,surname:"Zhang",slug:"tao-zhang",fullName:"Tao Zhang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9030",title:"Perspectives on Economic Development",subtitle:"Public Policy, Culture, and Economic Development",isOpenForSubmission:!1,hash:"8167ab72010ab459c0fc080da946ae8c",slug:"perspectives-on-economic-development-public-policy-culture-and-economic-development",bookSignature:"Ryan Merlin Yonk and Vito Bobek",coverURL:"https://cdn.intechopen.com/books/images_new/9030.jpg",editedByType:"Edited by",editors:[{id:"196259",title:"Dr.",name:"Ryan Merlin",middleName:null,surname:"Yonk",slug:"ryan-merlin-yonk",fullName:"Ryan Merlin Yonk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8150",title:"Elements of Bioeconomy",subtitle:null,isOpenForSubmission:!1,hash:"f5a930b0695ff23259fe96f219ff9a15",slug:"elements-of-bioeconomy",bookSignature:"Krzysztof Biernat",coverURL:"https://cdn.intechopen.com/books/images_new/8150.jpg",editedByType:"Edited by",editors:[{id:"155009",title:"Prof.",name:"Krzysztof",middleName:null,surname:"Biernat",slug:"krzysztof-biernat",fullName:"Krzysztof Biernat"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6008",title:"Taxes and Taxation Trends",subtitle:null,isOpenForSubmission:!1,hash:"ab59d9449969c67a1365d8b852094898",slug:"taxes-and-taxation-trends",bookSignature:"Jolanta Iwin-Garzy?ska",coverURL:"https://cdn.intechopen.com/books/images_new/6008.jpg",editedByType:"Edited by",editors:[{id:"203547",title:"Prof.",name:"Jolanta",middleName:null,surname:"Iwin-Garzyńska",slug:"jolanta-iwin-garzynska",fullName:"Jolanta Iwin-Garzyńska"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5819",title:"Research and Development Evolving Trends and Practices",subtitle:"Towards Human, Institutional and Economic Sectors Growth",isOpenForSubmission:!1,hash:"7e551ea4bdbca2454d3f7abb2837814d",slug:"research-and-development-evolving-trends-and-practices-towards-human-institutional-and-economic-sectors-growth",bookSignature:"Soha Maad",coverURL:"https://cdn.intechopen.com/books/images_new/5819.jpg",editedByType:"Edited by",editors:[{id:"7692",title:"Dr.",name:"Soha",middleName:null,surname:"Maad",slug:"soha-maad",fullName:"Soha Maad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:5,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"70618",doi:"10.5772/intechopen.90631",title:"Why Coevolution of Culture and Institutions Matters for Economic Development and Growth?",slug:"why-coevolution-of-culture-and-institutions-matters-for-economic-development-and-growth-",totalDownloads:702,totalCrossrefCites:3,totalDimensionsCites:15,abstract:"Theoretical considerations that choose to make reference to the institutional and cultural considerations presuppose that these are in an optimal form. However, this is not the case in the real world. This chapter argues that the coevolution requirements of institutional and culture change are critical for economic outcomes. When institutions and culture coevolve in an optimal pattern, economic development and growth are facilitated. In contrast, when institutions and culture deviate from the optimal pace of coevolution, incompatible alterations of institutions and culture may end up causing an inability of the policy designers to implement the required changes in institutions and/or cultural behaviors. The result can be a series of failing attempts to implement a modernized progrowth framework of institutional settings and cultural behaviors. Using a dataset of 80 countries for the period 1981–2019, the analysis concludes that institutions and culture are complements—and not substitutes—in terms of their role in economic development, as when both sizes are strong it leads to higher levels of GDP per capita. When either or both of them are at a weak level, economic development is much lower.",book:{id:"9030",slug:"perspectives-on-economic-development-public-policy-culture-and-economic-development",title:"Perspectives on Economic Development",fullTitle:"Perspectives on Economic Development - Public Policy, Culture, and Economic Development"},signatures:"Kyriaki I. Kafka, Pantelis C. Kostis and Panagiotis E. Petrakis",authors:null},{id:"68007",doi:"10.5772/intechopen.85036",title:"Overview of the Process of Enzymatic Transformation of Biomass",slug:"overview-of-the-process-of-enzymatic-transformation-of-biomass",totalDownloads:1377,totalCrossrefCites:4,totalDimensionsCites:5,abstract:"Cellulase is an enzyme which depolymerizes the cellulose into glucose. Cellulases are produced by a diverse array of microbes including fungi, bacteria, yeast and actinomycetes. Considerable research for understanding the mechanism of cellulases began in early 1950s because of the significant use of these enzymes in various industries. This review provides a general account structure and availability of lignocellulosic biomass, pretreatment strategies for effective digestion, cellulase producing organisms, cellulase activity assay, and enzymology of cellulose degradation. Cellulase production, optimization, purification and characterization studies in addition to the industrial application of cellulase have also been discussed. At last a brief account of present market scenario of cellulases and future prospects of the study are also taken into account.",book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Namita Singh, Anita Devi, Manju Bala Bishnoi, Rajneesh Jaryal, Avni Dahiya, Oleksandr Tashyrev and Vira Hovorukha",authors:[{id:"278205",title:"Prof.",name:"Namita",middleName:null,surname:"Singh",slug:"namita-singh",fullName:"Namita Singh"},{id:"282352",title:"Dr.",name:"Anita",middleName:null,surname:"Devi",slug:"anita-devi",fullName:"Anita Devi"},{id:"282353",title:"MSc.",name:"Avni",middleName:null,surname:"Dahiya",slug:"avni-dahiya",fullName:"Avni Dahiya"},{id:"282354",title:"MSc.",name:"Manju Bala",middleName:null,surname:"Bishnoi",slug:"manju-bala-bishnoi",fullName:"Manju Bala Bishnoi"},{id:"282355",title:"Dr.",name:"Oleksandr",middleName:null,surname:"Tashyrev",slug:"oleksandr-tashyrev",fullName:"Oleksandr Tashyrev"},{id:"282356",title:"Dr.",name:"Rajneesh",middleName:null,surname:"Jaryal",slug:"rajneesh-jaryal",fullName:"Rajneesh Jaryal"},{id:"282939",title:"Dr.",name:"Vira",middleName:null,surname:"Hovorukha",slug:"vira-hovorukha",fullName:"Vira Hovorukha"}]},{id:"56708",doi:"10.5772/intechopen.69096",title:"Human Development and Research-Development-Extension Relationships",slug:"human-development-and-research-development-extension-relationships",totalDownloads:1733,totalCrossrefCites:1,totalDimensionsCites:5,abstract:"Human capital is the most important strategic factor for development; as new technologies emerge, the market demand for better and healthier products and consumer demand in terms of quality and delivery time are changing. In today’s world, it becomes increasingly important to know how information can be accessed, how it is adopted, and how it can be assimilated. In this respect, each country allocates budget for training, education, and extension according to its own conditions. This budget may be intended for rural community-based social assistance, but the economic and welfare effect is essential. In this way, it is aimed to increase the living standards of the families living in the rural areas. This will naturally contribute to national income and to the prosperity of society. The subject has been discussed generally in the world, especially in the case of Turkey. According to this, all over the world, particularly in developing countries, research and extension (R&E) is very important and should be considered at least as much as research and development (R&D). However, it will be ensured that societies meet with the technology produced. For this, the development of human resources should be emphasized and a suitable atmosphere should be prepared for this widespread prosperity.",book:{id:"5819",slug:"research-and-development-evolving-trends-and-practices-towards-human-institutional-and-economic-sectors-growth",title:"Research and Development Evolving Trends and Practices",fullTitle:"Research and Development Evolving Trends and Practices - Towards Human, Institutional and Economic Sectors Growth"},signatures:"Orhan Özçatalbaş",authors:[{id:"170206",title:"Prof.",name:"Dr. Orhan",middleName:null,surname:"Özçatalbaş",slug:"dr.-orhan-ozcatalbas",fullName:"Dr. Orhan Özçatalbaş"}]},{id:"59430",doi:"10.5772/intechopen.74381",title:"Taxation and Economic Growth in a Resource-Rich Country: The Case of Nigeria",slug:"taxation-and-economic-growth-in-a-resource-rich-country-the-case-of-nigeria",totalDownloads:3858,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"In this chapter, we examine the relationship between taxation and economic growth in a resource rich country, using Nigeria as a case study. We explore the linkages between availability of higher resource revenue and lower taxation effort of other revenue categories and the effects of these on growth. Ordinary least square (OLS) estimation technique is employed in estimating the specified model. Also, descriptive analysis is carried out regarding tax trends and tax efforts in Nigeria to determine the effectiveness of existing tax structures, as well to as examine relevant national and cross-country data. Empirical results reveal that taxation has a significant impact on Real GDP growth rates. However, the proportion of tax contribution to the growth rate falls short of the optimal level in terms of the volume of economic activities and value of total output. Nigeria also lags other African countries with respect to tax effort and as such has a huge untapped potential for enhanced revenue mobilisation. We recommend therefore, that the Government should institute an appropriate tax system with an emphasis on broadening the tax base and in some cases, reviewing upwards the tax rates in order to increase the tax effort as well as ensure optimal contribution of taxation towards economic growth and development.",book:{id:"6008",slug:"taxes-and-taxation-trends",title:"Taxes and Taxation Trends",fullTitle:"Taxes and Taxation Trends"},signatures:"Ojijo Odhiambo and Oluwatosin Olushola",authors:[{id:"203736",title:"Mr.",name:"Ojijo",middleName:null,surname:"Odhiambo",slug:"ojijo-odhiambo",fullName:"Ojijo Odhiambo"},{id:"206483",title:"Mr.",name:"Oluwatosin",middleName:null,surname:"Olushola",slug:"oluwatosin-olushola",fullName:"Oluwatosin Olushola"}]},{id:"66110",doi:"10.5772/intechopen.84770",title:"Gold Recovery Process from Primary and Secondary Resources Using Bioadsorbents",slug:"gold-recovery-process-from-primary-and-secondary-resources-using-bioadsorbents",totalDownloads:1994,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Bioadsorbents were prepared in a simple manner only by treating in boiling concentrated sulfuric acid from various biomass materials such as various polysaccharides, persimmon tannin, cotton, paper and biomass wastes such as orange juice residue and microalgae residue after extracting biofuel. These bioadsorbents exhibited high selectivity only to gold over other metals and extraordinary high loading capacity for gold(III), which were elucidated to be attributable to the selective reduction of gold(III) ion to elemental gold due to its highest oxidation-reduction potential of gold(III) of metal ions, catalyzed by the surface of bioadsorbents prepared in boiling sulfuric acid. By using these biosorbents, recovery of gold from actual samples of printed circuit boards of spent mobile phones and Mongolian gold ore was investigated. Recovery of trace concentration of gold(I) from simulated spent alkaline cyanide solution was also investigated using the bioadsorbent. Application of bioadsorbents to some recovery processes of gold from cyanide solutions was proposed.",book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Katsutoshi Inoue, Durga Parajuli, Manju Gurung, Bimala Pangeni, Kanjana Khunathai, Keisuke Ohto and Hidetaka Kawakita",authors:[{id:"198951",title:"Prof.",name:"Keisuke",middleName:null,surname:"Ohto",slug:"keisuke-ohto",fullName:"Keisuke Ohto"},{id:"259238",title:"Dr.",name:"Hidetaka",middleName:null,surname:"Kawakita",slug:"hidetaka-kawakita",fullName:"Hidetaka Kawakita"},{id:"289372",title:"Dr.",name:"Katsutoshi",middleName:null,surname:"Inoue",slug:"katsutoshi-inoue",fullName:"Katsutoshi Inoue"},{id:"298633",title:"Dr.",name:"Bimala",middleName:null,surname:"Pangeni",slug:"bimala-pangeni",fullName:"Bimala Pangeni"},{id:"298634",title:"Dr.",name:"Manju",middleName:null,surname:"Gurung",slug:"manju-gurung",fullName:"Manju Gurung"},{id:"298635",title:"Dr.",name:"Kanjana",middleName:null,surname:"Khunathai",slug:"kanjana-khunathai",fullName:"Kanjana Khunathai"},{id:"298636",title:"Dr.",name:"Durga",middleName:null,surname:"Parajuli",slug:"durga-parajuli",fullName:"Durga Parajuli"}]}],mostDownloadedChaptersLast30Days:[{id:"66110",title:"Gold Recovery Process from Primary and Secondary Resources Using Bioadsorbents",slug:"gold-recovery-process-from-primary-and-secondary-resources-using-bioadsorbents",totalDownloads:1989,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Bioadsorbents were prepared in a simple manner only by treating in boiling concentrated sulfuric acid from various biomass materials such as various polysaccharides, persimmon tannin, cotton, paper and biomass wastes such as orange juice residue and microalgae residue after extracting biofuel. These bioadsorbents exhibited high selectivity only to gold over other metals and extraordinary high loading capacity for gold(III), which were elucidated to be attributable to the selective reduction of gold(III) ion to elemental gold due to its highest oxidation-reduction potential of gold(III) of metal ions, catalyzed by the surface of bioadsorbents prepared in boiling sulfuric acid. By using these biosorbents, recovery of gold from actual samples of printed circuit boards of spent mobile phones and Mongolian gold ore was investigated. Recovery of trace concentration of gold(I) from simulated spent alkaline cyanide solution was also investigated using the bioadsorbent. Application of bioadsorbents to some recovery processes of gold from cyanide solutions was proposed.",book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Katsutoshi Inoue, Durga Parajuli, Manju Gurung, Bimala Pangeni, Kanjana Khunathai, Keisuke Ohto and Hidetaka Kawakita",authors:[{id:"198951",title:"Prof.",name:"Keisuke",middleName:null,surname:"Ohto",slug:"keisuke-ohto",fullName:"Keisuke Ohto"},{id:"259238",title:"Dr.",name:"Hidetaka",middleName:null,surname:"Kawakita",slug:"hidetaka-kawakita",fullName:"Hidetaka Kawakita"},{id:"289372",title:"Dr.",name:"Katsutoshi",middleName:null,surname:"Inoue",slug:"katsutoshi-inoue",fullName:"Katsutoshi Inoue"},{id:"298633",title:"Dr.",name:"Bimala",middleName:null,surname:"Pangeni",slug:"bimala-pangeni",fullName:"Bimala Pangeni"},{id:"298634",title:"Dr.",name:"Manju",middleName:null,surname:"Gurung",slug:"manju-gurung",fullName:"Manju Gurung"},{id:"298635",title:"Dr.",name:"Kanjana",middleName:null,surname:"Khunathai",slug:"kanjana-khunathai",fullName:"Kanjana Khunathai"},{id:"298636",title:"Dr.",name:"Durga",middleName:null,surname:"Parajuli",slug:"durga-parajuli",fullName:"Durga Parajuli"}]},{id:"59430",title:"Taxation and Economic Growth in a Resource-Rich Country: The Case of Nigeria",slug:"taxation-and-economic-growth-in-a-resource-rich-country-the-case-of-nigeria",totalDownloads:3853,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"In this chapter, we examine the relationship between taxation and economic growth in a resource rich country, using Nigeria as a case study. We explore the linkages between availability of higher resource revenue and lower taxation effort of other revenue categories and the effects of these on growth. Ordinary least square (OLS) estimation technique is employed in estimating the specified model. Also, descriptive analysis is carried out regarding tax trends and tax efforts in Nigeria to determine the effectiveness of existing tax structures, as well to as examine relevant national and cross-country data. Empirical results reveal that taxation has a significant impact on Real GDP growth rates. However, the proportion of tax contribution to the growth rate falls short of the optimal level in terms of the volume of economic activities and value of total output. Nigeria also lags other African countries with respect to tax effort and as such has a huge untapped potential for enhanced revenue mobilisation. We recommend therefore, that the Government should institute an appropriate tax system with an emphasis on broadening the tax base and in some cases, reviewing upwards the tax rates in order to increase the tax effort as well as ensure optimal contribution of taxation towards economic growth and development.",book:{id:"6008",slug:"taxes-and-taxation-trends",title:"Taxes and Taxation Trends",fullTitle:"Taxes and Taxation Trends"},signatures:"Ojijo Odhiambo and Oluwatosin Olushola",authors:[{id:"203736",title:"Mr.",name:"Ojijo",middleName:null,surname:"Odhiambo",slug:"ojijo-odhiambo",fullName:"Ojijo Odhiambo"},{id:"206483",title:"Mr.",name:"Oluwatosin",middleName:null,surname:"Olushola",slug:"oluwatosin-olushola",fullName:"Oluwatosin Olushola"}]},{id:"71401",title:"Budget Deficit and the Federal Government Debt in Malaysia",slug:"budget-deficit-and-the-federal-government-debt-in-malaysia",totalDownloads:1180,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"In general, most countries in the world, particularly developing countries, are facing significant budget constraints, in which the collection of tax and nontax revenues is less than the government’s total expenditure. Therefore, borrowing either from the local capital or international capital markets is made. Borrowing increases government debts. The budget deficits and the growth of the government debt are the major factors that determine the health of macroeconomics. There is a solid consensus among economists mainly on the effect of budget deficits on macroeconomics in terms of crowding out private investment, increasing interest rates, expanding money supply and escalating consumer price and in certain extent affect exchange rate. Government bonds issued to finance budget deficits are also in question as part of the net wealth of private sectors. On the other side, there is an agreement that the budget deficits financed by the issuance of bonds will crowd out private investment through increasing interest rate. This paper plans to investigate the impact of budget deficits on Malaysia’s economy. Cointegration test and vector error correction models are used to examine the impact of budget deficits on certain macroeconomic variables.",book:{id:"9030",slug:"perspectives-on-economic-development-public-policy-culture-and-economic-development",title:"Perspectives on Economic Development",fullTitle:"Perspectives on Economic Development - Public Policy, Culture, and Economic Development"},signatures:"Mohamed Aslam and Raihan Jaafar",authors:null},{id:"56708",title:"Human Development and Research-Development-Extension Relationships",slug:"human-development-and-research-development-extension-relationships",totalDownloads:1731,totalCrossrefCites:1,totalDimensionsCites:5,abstract:"Human capital is the most important strategic factor for development; as new technologies emerge, the market demand for better and healthier products and consumer demand in terms of quality and delivery time are changing. In today’s world, it becomes increasingly important to know how information can be accessed, how it is adopted, and how it can be assimilated. In this respect, each country allocates budget for training, education, and extension according to its own conditions. This budget may be intended for rural community-based social assistance, but the economic and welfare effect is essential. In this way, it is aimed to increase the living standards of the families living in the rural areas. This will naturally contribute to national income and to the prosperity of society. The subject has been discussed generally in the world, especially in the case of Turkey. According to this, all over the world, particularly in developing countries, research and extension (R&E) is very important and should be considered at least as much as research and development (R&D). However, it will be ensured that societies meet with the technology produced. For this, the development of human resources should be emphasized and a suitable atmosphere should be prepared for this widespread prosperity.",book:{id:"5819",slug:"research-and-development-evolving-trends-and-practices-towards-human-institutional-and-economic-sectors-growth",title:"Research and Development Evolving Trends and Practices",fullTitle:"Research and Development Evolving Trends and Practices - Towards Human, Institutional and Economic Sectors Growth"},signatures:"Orhan Özçatalbaş",authors:[{id:"170206",title:"Prof.",name:"Dr. Orhan",middleName:null,surname:"Özçatalbaş",slug:"dr.-orhan-ozcatalbas",fullName:"Dr. Orhan Özçatalbaş"}]},{id:"68851",title:"Introductory Chapter: Objectives and Scope of Bioeconomy",slug:"introductory-chapter-objectives-and-scope-of-bioeconomy",totalDownloads:964,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"8150",slug:"elements-of-bioeconomy",title:"Elements of Bioeconomy",fullTitle:"Elements of Bioeconomy"},signatures:"Krzysztof Biernat",authors:[{id:"155009",title:"Prof.",name:"Krzysztof",middleName:null,surname:"Biernat",slug:"krzysztof-biernat",fullName:"Krzysztof Biernat"}]}],onlineFirstChaptersFilter:{topicId:"66",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. In brief, we hope that books in this series will provide accessible references for those interested or working in this field and encourage learning in a range of different topics.",coverUrl:"https://cdn.intechopen.com/series/covers/13.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:10,editor:{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,annualVolume:11415,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,annualVolume:11416,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,annualVolume:11417,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. Portugal",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:0,paginationItems:[]},overviewPagePublishedBooks:{paginationCount:0,paginationItems:[]},openForSubmissionBooks:{paginationCount:3,paginationItems:[{id:"11580",title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",hash:"1806716f60b9be14fc05682c4a912b41",secondStepPassed:!0,currentStepOfPublishingProcess:4,submissionDeadline:"March 23rd 2022",isOpenForSubmission:!0,editors:[{id:"258334",title:"Dr.",name:"Carlos Eduardo",surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11579",title:"Animal Welfare - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11579.jpg",hash:"12e4f41264cbe99028655e5463fa941a",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 1st 2022",isOpenForSubmission:!0,editors:[{id:"51520",title:"Dr.",name:"Shao-Wen",surname:"Hung",slug:"shao-wen-hung",fullName:"Shao-Wen Hung"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11578",title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",hash:"3731c009f474c6ed4293f348ca7b27ac",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 3rd 2022",isOpenForSubmission:!0,editors:[{id:"225390",title:"Dr.",name:"Asghar Ali",surname:"Kamboh",slug:"asghar-ali-kamboh",fullName:"Asghar Ali Kamboh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:17,paginationItems:[{id:"81751",title:"NanoBioSensors: From Electrochemical Sensors Improvement to Theranostic Applications",doi:"10.5772/intechopen.102552",signatures:"Anielle C.A. Silva, Eliete A. Alvin, Lais S. de Jesus, Caio C.L. de França, Marílya P.G. da Silva, Samaysa L. Lins, Diógenes Meneses, Marcela R. Lemes, Rhanoica O. Guerra, Marcos V. da Silva, Carlo J.F. de Oliveira, Virmondes Rodrigues Junior, Renata M. Etchebehere, Fabiane C. de Abreu, Bruno G. Lucca, Sanívia A.L. Pereira, Rodrigo C. Rosa and Noelio O. Dantas",slug:"nanobiosensors-from-electrochemical-sensors-improvement-to-theranostic-applications",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81766",title:"Evolution of Organoids in Oncology",doi:"10.5772/intechopen.104251",signatures:"Allen Thayakumar Basanthakumar, Janitha Chandrasekhar Darlybai and Jyothsna Ganesh",slug:"evolution-of-organoids-in-oncology",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81678",title:"Developmental Studies on Practical Enzymatic Phosphate Ion Biosensors and Microbial BOD Biosensors, and New Insights into the Future Perspectives of These Biosensor Fields",doi:"10.5772/intechopen.104377",signatures:"Hideaki Nakamura",slug:"developmental-studies-on-practical-enzymatic-phosphate-ion-biosensors-and-microbial-bod-biosensors-a",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hideaki",surname:"Nakamura"}],book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81547",title:"Organoids and Commercialization",doi:"10.5772/intechopen.104706",signatures:"Anubhab Mukherjee, Aprajita Sinha, Maheshree Maibam, Bharti Bisht and Manash K. Paul",slug:"organoids-and-commercialization",totalDownloads:33,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81412",title:"Mathematical Morphology and the Heart Signals",doi:"10.5772/intechopen.104113",signatures:"Taouli Sidi Ahmed",slug:"mathematical-morphology-and-the-heart-signals",totalDownloads:18,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81360",title:"Deep Learning Algorithms for Efficient Analysis of ECG Signals to Detect Heart Disorders",doi:"10.5772/intechopen.103075",signatures:"Sumagna Dey, Rohan Pal and Saptarshi Biswas",slug:"deep-learning-algorithms-for-efficient-analysis-of-ecg-signals-to-detect-heart-disorders",totalDownloads:31,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81294",title:"Applications of Neural Organoids in Neurodevelopment and Regenerative Medicine",doi:"10.5772/intechopen.104044",signatures:"Jing Gong, Jiahui Kang, Minghui Li, Xiao Liu, Jun Yang and Haiwei Xu",slug:"applications-of-neural-organoids-in-neurodevelopment-and-regenerative-medicine",totalDownloads:25,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81318",title:"Retinal Organoids over the Decade",doi:"10.5772/intechopen.104258",signatures:"Jing Yuan and Zi-Bing Jin",slug:"retinal-organoids-over-the-decade",totalDownloads:39,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81068",title:"Characteristic Profiles of Heart Rate Variability in Depression and Anxiety",doi:"10.5772/intechopen.104205",signatures:"Toshikazu Shinba",slug:"characteristic-profiles-of-heart-rate-variability-in-depression-and-anxiety",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"80691",title:"Applications of Quantum Mechanics, Laws of Classical Physics, and Differential Calculus to Evaluate Source Localization According to the Electroencephalogram",doi:"10.5772/intechopen.102831",signatures:"Kristin S. Williams",slug:"applications-of-quantum-mechanics-laws-of-classical-physics-and-differential-calculus-to-evaluate-so",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}}]},subseriesFiltersForOFChapters:[{caption:"Bioinformatics and Medical Informatics",value:7,count:13,group:"subseries"}],publishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",slug:"reactive-oxygen-species",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Rizwan Ahmad",hash:"176adcf090fdd1f93cb8ce3146e79ca1",volumeInSeries:28,fullTitle:"Reactive Oxygen Species",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",publishedDate:"March 23rd 2022",editedByType:"Edited by",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",hash:"8b43add5389ba85743e0a9491e4b9943",volumeInSeries:27,fullTitle:"Vitamin K - Recent Topics on the Biology and Chemistry",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10799",title:"Phenolic Compounds",subtitle:"Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10799.jpg",slug:"phenolic-compounds-chemistry-synthesis-diversity-non-conventional-industrial-pharmaceutical-and-therapeutic-applications",publishedDate:"February 23rd 2022",editedByType:"Edited by",bookSignature:"Farid A. Badria",hash:"339199f254d2987ef3167eef74fb8a38",volumeInSeries:26,fullTitle:"Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9659",title:"Fibroblasts",subtitle:"Advances in Inflammation, Autoimmunity and Cancer",coverURL:"https://cdn.intechopen.com/books/images_new/9659.jpg",slug:"fibroblasts-advances-in-inflammation-autoimmunity-and-cancer",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Mojca Frank Bertoncelj and Katja Lakota",hash:"926fa6446f6befbd363fc74971a56de2",volumeInSeries:25,fullTitle:"Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer",editors:[{id:"328755",title:"Ph.D.",name:"Mojca",middleName:null,surname:"Frank Bertoncelj",slug:"mojca-frank-bertoncelj",fullName:"Mojca Frank Bertoncelj",profilePictureURL:"https://mts.intechopen.com/storage/users/328755/images/system/328755.jpg",institutionString:"BioMed X Institute",institution:{name:"University Hospital of Zurich",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9753",title:"Terpenes and Terpenoids",subtitle:"Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/9753.jpg",slug:"terpenes-and-terpenoids-recent-advances",publishedDate:"July 28th 2021",editedByType:"Edited by",bookSignature:"Shagufta Perveen and Areej Mohammad Al-Taweel",hash:"575689df13c78bf0e6c1be40804cd010",volumeInSeries:21,fullTitle:"Terpenes and Terpenoids - Recent Advances",editors:[{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",institutionString:"King Saud University",institution:{name:"King Saud University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9403",title:"Human Microbiome",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9403.jpg",slug:"human-microbiome",publishedDate:"June 16th 2021",editedByType:"Edited by",bookSignature:"Natalia V. Beloborodova and Andrey V. Grechko",hash:"c31366ba82585ba3ac91d21eb1cf0a4d",volumeInSeries:20,fullTitle:"Human Microbiome",editors:[{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9731",title:"Oxidoreductase",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9731.jpg",slug:"oxidoreductase",publishedDate:"February 17th 2021",editedByType:"Edited by",bookSignature:"Mahmoud Ahmed Mansour",hash:"852e6f862c85fc3adecdbaf822e64e6e",volumeInSeries:19,fullTitle:"Oxidoreductase",editors:[{id:"224662",title:"Prof.",name:"Mahmoud Ahmed",middleName:null,surname:"Mansour",slug:"mahmoud-ahmed-mansour",fullName:"Mahmoud Ahmed Mansour",profilePictureURL:"https://mts.intechopen.com/storage/users/224662/images/system/224662.jpg",institutionString:"King Saud bin Abdulaziz University for Health Sciences",institution:{name:"King Saud bin Abdulaziz University for Health Sciences",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9742",title:"Ubiquitin",subtitle:"Proteasome Pathway",coverURL:"https://cdn.intechopen.com/books/images_new/9742.jpg",slug:"ubiquitin-proteasome-pathway",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Xianquan Zhan",hash:"af6880d3a5571da1377ac8f6373b9e82",volumeInSeries:18,fullTitle:"Ubiquitin - Proteasome Pathway",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",institutionURL:null,country:{name:"China"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9002",title:"Glutathione System and Oxidative Stress in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9002.jpg",slug:"glutathione-system-and-oxidative-stress-in-health-and-disease",publishedDate:"August 26th 2020",editedByType:"Edited by",bookSignature:"Margarete Dulce Bagatini",hash:"127defed0a50ad5ed92338dc96e1e10e",volumeInSeries:17,fullTitle:"Glutathione System and Oxidative Stress in Health and Disease",editors:[{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:3},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:8},{group:"subseries",caption:"Chemical Biology",value:15,count:10}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:3},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:249,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"39",type:"subseries",title:"Environmental Resilience and Management",keywords:"Anthropic effects, Overexploitation, Biodiversity loss, Degradation, Inadequate Management, SDGs adequate practices",scope:"
\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with the environment and promote the use of adequate management practices such as those outlined in the United Nations’ Sustainable Development Goals.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",hasOnlineFirst:!1,hasPublishedBooks:!1,annualVolume:11967,editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",slug:"jose-navarro-pedreno",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",biography:"Full professor at University Miguel Hernández of Elche, Spain, previously working at the University of Alicante, Autonomous University of Madrid and Polytechnic University of Valencia. Graduate in Sciences (Chemist), graduate in Geography and History (Geography), master in Water Management, Treatment, master in Fertilizers and Environment and master in Environmental Management; Ph.D. in Environmental Sciences. His research is focused on soil-water and waste-environment relations, mainly on soil-water and soil-waste interactions under different management and waste reuse. His work is reflected in more than 230 communications presented in national and international conferences and congresses, 29 invited lectures from universities, associations and government agencies. Prof. Navarro-Pedreño is also a director of the Ph.D. Program Environment and Sustainability (2012-present) and a member of several societies among which are the Spanish Society of Soil Science, International Union of Soil Sciences, European Society for Soil Conservation, DessertNet and the Spanish Royal Society of Chemistry.",institutionString:"Miguel Hernández University of Elche, Spain",institution:null},editorTwo:null,editorThree:null,series:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713"},editorialBoard:[{id:"177015",title:"Prof.",name:"Elke Jurandy",middleName:null,surname:"Bran Nogueira Cardoso",slug:"elke-jurandy-bran-nogueira-cardoso",fullName:"Elke Jurandy Bran Nogueira Cardoso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGxzQAG/Profile_Picture_2022-03-25T08:32:33.jpg",institutionString:"Universidade de São Paulo, Brazil",institution:null},{id:"211260",title:"Dr.",name:"Sandra",middleName:null,surname:"Ricart",slug:"sandra-ricart",fullName:"Sandra Ricart",profilePictureURL:"https://mts.intechopen.com/storage/users/211260/images/system/211260.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}}]},onlineFirstChapters:{paginationCount:9,paginationItems:[{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81681",title:"Immunomodulatory Effects of a M2-Conditioned Medium (PRS® CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic System",doi:"10.5772/intechopen.104486",signatures:"Juan Pedro Lapuente",slug:"immunomodulatory-effects-of-a-m2-conditioned-medium-prs-ck-storm-theory-on-the-possible-complex-mech",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81580",title:"Graft-Versus-Host Disease: Pathogenesis and Treatment",doi:"10.5772/intechopen.104450",signatures:"Shin Mukai",slug:"graft-versus-host-disease-pathogenesis-and-treatment",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"80485",title:"Potential Marker for Diagnosis and Screening of Iron Deficiency Anemia in Children",doi:"10.5772/intechopen.102792",signatures:"Yulia Nadar Indrasari, Siti Nurul Hapsari and Muhamad Robiul Fuadi",slug:"potential-marker-for-diagnosis-and-screening-of-iron-deficiency-anemia-in-children",totalDownloads:42,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"79693",title:"Ferroptosis: Can Iron be the Last or Cure for a Cell?",doi:"10.5772/intechopen.101426",signatures:"Asuman Akkaya Fırat",slug:"ferroptosis-can-iron-be-the-last-or-cure-for-a-cell",totalDownloads:90,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"79616",title:"Dietary Iron",doi:"10.5772/intechopen.101265",signatures:"Kouser Firdose and Noor Firdose",slug:"dietary-iron",totalDownloads:144,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"78977",title:"FERALGINE™ a New Oral iron Compound",doi:"10.5772/intechopen.100445",signatures:"Valentina Talarico, Laura Giancotti, Giuseppe Antonio Mazza, Santina Marrazzo, Roberto Miniero and Marco Bertini",slug:"feralgine-a-new-oral-iron-compound",totalDownloads:129,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}}]},publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"7437",title:"Nanomedicines",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7437.jpg",slug:"nanomedicines",publishedDate:"February 13th 2019",editedByType:"Edited by",bookSignature:"Muhammad Akhyar Farrukh",hash:"0e1f5f6258f074c533976c4f4d248568",volumeInSeries:5,fullTitle:"Nanomedicines",editors:[{id:"63182",title:"Dr.",name:"Muhammad Akhyar",middleName:null,surname:"Farrukh",slug:"muhammad-akhyar-farrukh",fullName:"Muhammad Akhyar Farrukh",profilePictureURL:"https://mts.intechopen.com/storage/users/63182/images/system/63182.png",institutionString:"Forman Christian College",institution:{name:"Forman Christian College",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/73306",hash:"",query:{},params:{id:"73306"},fullPath:"/chapters/73306",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()