Human activity valuation model.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10723",leadTitle:null,fullTitle:"Brachial Plexus Injury - New Techniques and Ideas",title:"Brachial Plexus Injury",subtitle:"New Techniques and Ideas",reviewType:"peer-reviewed",abstract:"In this book, specialists from different countries and continents share their knowledge and experience in brachial plexus surgery. It discusses the different types of brachial plexus injury and advances in surgical treatments.",isbn:"978-1-83969-687-9",printIsbn:"978-1-83969-686-2",pdfIsbn:"978-1-83969-688-6",doi:"10.5772/intechopen.94695",price:119,priceEur:129,priceUsd:155,slug:"brachial-plexus-injury-new-techniques-and-ideas",numberOfPages:176,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"94c1a38f1ee7a078ee6ec640360c39f2",bookSignature:"Jörg Bahm",publishedDate:"January 26th 2022",coverURL:"https://cdn.intechopen.com/books/images_new/10723.jpg",numberOfDownloads:1346,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:0,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 11th 2021",dateEndSecondStepPublish:"April 8th 2021",dateEndThirdStepPublish:"June 7th 2021",dateEndFourthStepPublish:"August 26th 2021",dateEndFifthStepPublish:"October 25th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"78207",title:"Prof.",name:"Jörg",middleName:null,surname:"Bahm",slug:"jorg-bahm",fullName:"Jörg Bahm",profilePictureURL:"https://mts.intechopen.com/storage/users/78207/images/system/78207.jpg",biography:"Jörg Bahm obtained an MD in 1987 and a Ph.D. from Université libre de Bruxelles (ULB), Brussels, Belgium in 2011. As a general, plastic, and hand surgeon, Dr. Bahm worked for five years at University Hospital Aachen, Germany. Since 1994, he has focused on brachial plexus surgery. He has been a chief surgeon in the Reconstructive Microsurgery Unit of the Franziskushospital, Aachen, Germany since 2000. In 2020, this unit was transferred into the Aachen University Hospital as the Division for Plexus Surgery within the Department for Plastic, Hand and Burn Surgery. \nSince 2003, Dr. Bahm has been a consultant for peripheral nerves in the Orthopaedic Department, Erasme University Hospital, Brussels, Belgium. He is an active member of the German (DGH) and Belgian (BHG) Hand Surgery Society and of the German Plastic Surgery Society (DGPRÄC). He is a member of the Narakas club for brachial plexus surgery and editor of the online Journal of Brachial Plexus and Peripheral Nerve Injury. He has written more than 50 scientific papers and presented at more than 200 congresses.\nDr. Bahm was president of the BHG in 2012 and 2013 and congress president of the FESSH Hand Surgery congress 2012 in Antwerp, Belgium.\nHis specific interests are peripheral nerve surgery and microsurgical reconstruction of the upper limb.",institutionString:"RWTH University Hospital",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Universitätsklinikum Aachen",institutionURL:null,country:{name:"Germany"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1148",title:"Neurosurgery",slug:"neurosurgery"}],chapters:[{id:"79635",title:"Introductory Chapter: Treatment of Brachial Plexus Lesions - A New Transdisciplinary Approach",doi:"10.5772/intechopen.101547",slug:"introductory-chapter-treatment-of-brachial-plexus-lesions-a-new-transdisciplinary-approach",totalDownloads:59,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Jörg Bahm",downloadPdfUrl:"/chapter/pdf-download/79635",previewPdfUrl:"/chapter/pdf-preview/79635",authors:[{id:"78207",title:"Prof.",name:"Jörg",surname:"Bahm",slug:"jorg-bahm",fullName:"Jörg Bahm"}],corrections:null},{id:"77532",title:"Nerve Transfers for Restoring Elbow Flexion in Brachial Plexus Palsy",doi:"10.5772/intechopen.98869",slug:"nerve-transfers-for-restoring-elbow-flexion-in-brachial-plexus-palsy",totalDownloads:158,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Nerve transfers (NT) consist in sectioning a donor nerve and connecting it to the distal stump of a recipient unrepairable nerve. For elbow flexion restoration in brachial plexus palsy (BPP) we used different NT: 1) GF motor Ulnar Nerve to Biceps nerve (Oberlin technique), 2) Double fascicular median/ulnar to biceps/brachialis nerve transfer (Mackinnon), 3) InterCostal Nerves (ICN) to MCN (+/− nerve graft), 4) Medial Pectoral Nerve (MPN) to MCN, 5) ThoracoDorsal Nerve (TDN) to MCN, 6) Spinal Accessory Nerve (SAN) to MCN transfer, 7) Phrenic Nerve (PhN) to MCN, 8) Cervical Plexus C3-C4 to MCN and 9) Contralateral C7 (CC7). I want to present my personal experience using the phrenic nerve (PhN), the intercostal nerves (ICN) and Oberlin’s technique. The aim of this retrospective study is to evaluate the results of this procedure in BPP. NT is an important goal in BPP. ICN transfer into the nerve of biceps for elbow flexion recovery is a reliable procedure in BPP. ICN transfer for triceps offers a positive alternative (Carroll transposition). Oberlin technique is simple and offers better results in a shorter amount of time and is an effective and safe option.",signatures:"Teodor Stamate and Dan Cristian Moraru",downloadPdfUrl:"/chapter/pdf-download/77532",previewPdfUrl:"/chapter/pdf-preview/77532",authors:[{id:"356223",title:"Emeritus Prof.",name:"Teodor",surname:"Stamate",slug:"teodor-stamate",fullName:"Teodor Stamate"},{id:"422017",title:"Dr.",name:"Dan Cristian",surname:"Moraru",slug:"dan-cristian-moraru",fullName:"Dan Cristian Moraru"}],corrections:null},{id:"77904",title:"Nerve Transfers to Recover External Rotation of the Shoulder after Brachial Plexus Injuries in Adults",doi:"10.5772/intechopen.99330",slug:"nerve-transfers-to-recover-external-rotation-of-the-shoulder-after-brachial-plexus-injuries-in-adult",totalDownloads:113,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Restoration of external rotation of the shoulder in adults with partial brachial plexus palsies is challenging. While nerve grafts are possible, nerve transfers are currently the most use method for satisfactory restoration of function. Numerous nerve transfers have been described, although the transfer of the spinal accessory nerve to the suprascapular nerve remains the gold standard. The suprascapular nerve and the nerve to the teres minor muscle are the two preferred targets to restore external rotation of the shoulder. There are numerous nerve donors, but their use obviously depends on the initial injury. The most common donors are the spinal accessory nerve, the rhomboid nerve, branches of the radial nerve, the C7 root fascicle or the ulnar nerve. The choice for the transfer depends on the available nerves and first of all on chosen approach, whether it be cervical or scapular. It also depends on the other associated reconstruction procedures, grafts, or nerve transfers for the recovery of other functions, specifically, elevation of the shoulder and flexion of the elbow. The objective of this chapter is to present the main nerve transfers and to propose a therapeutic strategy.",signatures:"Jean-Noel Goubier, Camille Echalier, Elodie Dubois and Frédéric Teboul",downloadPdfUrl:"/chapter/pdf-download/77904",previewPdfUrl:"/chapter/pdf-preview/77904",authors:[{id:"40328",title:"Dr.",name:"Jean-Noel",surname:"Goubier",slug:"jean-noel-goubier",fullName:"Jean-Noel Goubier"},{id:"414005",title:"Dr.",name:"Frédéric",surname:"Teboul",slug:"frederic-teboul",fullName:"Frédéric Teboul"},{id:"414006",title:"Dr.",name:"Camille",surname:"Echalier",slug:"camille-echalier",fullName:"Camille Echalier"},{id:"414628",title:"Dr.",name:"Elodie",surname:"Dubois",slug:"elodie-dubois",fullName:"Elodie Dubois"}],corrections:null},{id:"78166",title:"Derotational Osteotomies for The Late Treatment of Brachial Plexus Injury",doi:"10.5772/intechopen.99679",slug:"derotational-osteotomies-for-the-late-treatment-of-brachial-plexus-injury",totalDownloads:101,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Obstetric brachial plexus palsy [OBBP] can affect the function of the upper extremity. Most of the injuries are limited to the upper spinal nerves and heals spontaneously. However, some of them will have incomplete recovery after OBBP often results in weakness of the external rotators [teres minor and infraspinatus] muscles compared to the internal rotators [teres major, pectoralis major, latissimus dorsi] muscles. The predominance of the internal rotators and adductor muscles over external rotators leads to an internal rotation contracture. The development of internal rotational deformity may progress to increased glenoid retroversion and posterior humeral head subluxation. If the surgeon does not repair internal rotation deformity, the humeral head is forced into a posterior position causing a complete posterior dislocation. Many procedures are performed to treat these deformities: In the young child, improving the remodeling of the glenohumeral joint, capsulectomy, and subscapular release are introduced. Tendon transfers of the shoulder have good results for motion but fail to restore the glenohumeral joint. The failure of improving joint alignment may represent the loss in clinical improvement over time. In older children, a humeral osteotomy can be an alternative to realign the limb into external rotation, improve appearance, and enhance eating, washing hair, and scratching the back of the neck. We will discuss all the techniques along with their advantages and disadvantages.",signatures:"Ahmet Emrah Açan and Ertuğrul Şahin",downloadPdfUrl:"/chapter/pdf-download/78166",previewPdfUrl:"/chapter/pdf-preview/78166",authors:[{id:"356769",title:"Associate Prof.",name:"Ahmet Emrah",surname:"Açan",slug:"ahmet-emrah-acan",fullName:"Ahmet Emrah Açan"},{id:"426178",title:"Dr.",name:"Ertuğrul",surname:"Şahin",slug:"ertugrul-sahin",fullName:"Ertuğrul Şahin"}],corrections:null},{id:"78304",title:"The Role of Functional Electrical Stimulation in Brachial Plexus Injury Repair",doi:"10.5772/intechopen.99660",slug:"the-role-of-functional-electrical-stimulation-in-brachial-plexus-injury-repair",totalDownloads:356,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Brachial plexus injury (BPI) is a type of peripheral nerve injury, which is mainly manifested as upper limb sensory and motor dysfunction. Although the injury will not endanger life, it can cause serious functional loss and high disability rate, and eventually lead to patients unable to live normally. At present, the treatment methods for BPI mainly include conservative treatment, such as limb massage, exercise, drug therapy, autonomous movement and strength training; In clinic, nerve repair, nerve transplantation and muscle transfer can also be used. Although surgical treatment can better restore the function of injured brachial plexus, there is a certain risk, so it is not the first choice of treatment. As a mature electrical stimulation method, functional electrical stimulation (FES) can play a good role in promoting injured nerve regeneration and preventing skeletal muscle denervation atrophy, so it can be widely used in the treatment and functional recovery of BPI. This article will review the research progress of FES in the treatment of BPI.",signatures:"Lin Yang, Yaxuan Li, Qianling Zhang, Mengnan Jiang and Jia He",downloadPdfUrl:"/chapter/pdf-download/78304",previewPdfUrl:"/chapter/pdf-preview/78304",authors:[{id:"314534",title:"Dr.",name:"Lin",surname:"Yang",slug:"lin-yang",fullName:"Lin Yang"},{id:"414339",title:"Ms.",name:"Jia",surname:"He",slug:"jia-he",fullName:"Jia He"},{id:"414341",title:"MSc.",name:"YaXuan",surname:"Li",slug:"yaxuan-li",fullName:"YaXuan Li"},{id:"414342",title:"Ms.",name:"MengNan",surname:"Jiang",slug:"mengnan-jiang",fullName:"MengNan Jiang"},{id:"421931",title:"BSc.",name:"Qianling",surname:"Zhang",slug:"qianling-zhang",fullName:"Qianling Zhang"}],corrections:null},{id:"77527",title:"Outcome Measures in OBPP",doi:"10.5772/intechopen.98796",slug:"outcome-measures-in-obpp",totalDownloads:160,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Traditional outcome measurement scales, such as the Medical Research Council (MRC) score, the Active Movement Scale (AMS), and Mallet score, are used by surgeons to assess outcomes in patients with obstetric brachial plexus palsy (OBPP). The measurement scales used to evaluate patients fall under the International Classification of Functioning (ICF) domains of Body Function, Body Structure, Activity, Participation, and Environment and are used to assess function and disability of patients. Currently used outcome measures scales for OBPP are also contrasted with those used for another perinatal condition affecting the upper limb, cerebral palsy (CP).",signatures:"Shivani Gupta, Nivetha Srinivasan, Jasmine Mahajan, Amy Song, Alice Chu and Aleksandra McGrath",downloadPdfUrl:"/chapter/pdf-download/77527",previewPdfUrl:"/chapter/pdf-preview/77527",authors:[{id:"414275",title:"Dr.",name:"Aleksandra",surname:"McGrath",slug:"aleksandra-mcgrath",fullName:"Aleksandra McGrath"},{id:"414279",title:"Dr.",name:"Alice",surname:"Chu",slug:"alice-chu",fullName:"Alice Chu"},{id:"418526",title:"B.Sc.",name:"Nivetha",surname:"Srinivasan",slug:"nivetha-srinivasan",fullName:"Nivetha Srinivasan"},{id:"418527",title:"B.Sc.",name:"Jasmine",surname:"Mahajan",slug:"jasmine-mahajan",fullName:"Jasmine Mahajan"},{id:"418529",title:"B.Sc.",name:"Shivani",surname:"Gupta",slug:"shivani-gupta",fullName:"Shivani Gupta"},{id:"422006",title:"B.Sc.",name:"Amy",surname:"Song",slug:"amy-song",fullName:"Amy Song"}],corrections:null},{id:"77632",title:"Factors of Cortical Plasticity in Brachial Plexus Injury",doi:"10.5772/intechopen.98822",slug:"factors-of-cortical-plasticity-in-brachial-plexus-injury",totalDownloads:109,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Cortical plasticity is the brain’s capability of decoding new information through growth and reorganization over our whole life spam. It is the basis for good outcomes after reinnervation and for rehabilitation of adult and obstetric brachial plexus injury. Knowledge about cortical reorganization is crucial to reconstructive surgeons and physiotherapists that aim to give their patients a reasonable prognosis. This chapter intends to present and summarize the current literature on how to detect and quantify cortical plasticity and how research on factors that influence cortical plasticity, mainly in relation to peripheral nerve and more precise brachial plexus injury progresses. Peculiarities of adult and obstetric brachial plexus injuries and their treatment are given. We present techniques that visualize and quantify cortical plasticity with focus on functional imaging like fMRI and nTMS as well as molecular aspects. Future research is needed to understand mechanisms of how molecular changes on a synaptic level of a neuron influence the macroscopic plasticity, to improve rehabilitative resources, to understand the exact prognostic value of nTMS in brachial plexus injury and to investigate the therapeutic capability of rTMS.",signatures:"Jennifer Reinsch, Anna Zdunczyk, Tarik Alp Sargut, Maren Denker, Melina Engelhardt, Peter Vajkoczy, Thomas Picht and Nora Dengler",downloadPdfUrl:"/chapter/pdf-download/77632",previewPdfUrl:"/chapter/pdf-preview/77632",authors:[{id:"355641",title:"Associate Prof.",name:"Nora F.",surname:"Dengler",slug:"nora-f.-dengler",fullName:"Nora F. Dengler"},{id:"418293",title:"Ms.",name:"Jennifer",surname:"Reinsch",slug:"jennifer-reinsch",fullName:"Jennifer Reinsch"},{id:"422165",title:"Dr.",name:"Anna",surname:"Zdunczyk",slug:"anna-zdunczyk",fullName:"Anna Zdunczyk"},{id:"422168",title:"Dr.",name:"Tarik Alp",surname:"Sargut",slug:"tarik-alp-sargut",fullName:"Tarik Alp Sargut"},{id:"422170",title:"Ms.",name:"Maren",surname:"Denker",slug:"maren-denker",fullName:"Maren Denker"},{id:"422171",title:"MSc.",name:"Melina",surname:"Engelhardt",slug:"melina-engelhardt",fullName:"Melina Engelhardt"},{id:"422172",title:"Prof.",name:"Peter",surname:"Vajkoczy",slug:"peter-vajkoczy",fullName:"Peter Vajkoczy"},{id:"422173",title:"Prof.",name:"Thomas",surname:"Picht",slug:"thomas-picht",fullName:"Thomas Picht"}],corrections:null},{id:"78316",title:"Effects of Timing of Nerve Injury and Repair in Neonatal and Adult Brachial Plexus Injury Models",doi:"10.5772/intechopen.99359",slug:"effects-of-timing-of-nerve-injury-and-repair-in-neonatal-and-adult-brachial-plexus-injury-models",totalDownloads:120,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Brachial plexus Injury causes severe and long-term upper limb deficits at any age. The outcome from current reconstructive options depends on the severity of nerve injury and timing of intervention. This chapter summarises the differing biological responses to nerve injury that occur during neonatal, young adult and mature adult life. The central and peripheral reactions to nerve injury, the effects of timing of repair on both motor and sensory neuronal survival and basic science evidence to support early intervention are discussed.",signatures:"Grainne Bourke, Lev Novikov, Andrew Hart and Mikael Wiberg",downloadPdfUrl:"/chapter/pdf-download/78316",previewPdfUrl:"/chapter/pdf-preview/78316",authors:[{id:"355857",title:"Dr.",name:"Grainne",surname:"Bourke",slug:"grainne-bourke",fullName:"Grainne Bourke"},{id:"355858",title:"Prof.",name:"Mikael",surname:"Wiberg",slug:"mikael-wiberg",fullName:"Mikael Wiberg"},{id:"355859",title:"Prof.",name:"Lev",surname:"Novikov",slug:"lev-novikov",fullName:"Lev Novikov"},{id:"355860",title:"Prof.",name:"Andrew",surname:"Hart",slug:"andrew-hart",fullName:"Andrew Hart"}],corrections:null},{id:"79557",title:"A Funhouse Mirror: Muscular Co-Contractions as a Reflection of a Spontaneous Aberrant Regeneration of the Brachial Plexus Injury in the Adults - Anatomical Background, an Attempt to Classify and Their Clinical Relevance within the Reconstruction Strategie",doi:"10.5772/intechopen.100609",slug:"a-funhouse-mirror-muscular-co-contractions-as-a-reflection-of-a-spontaneous-aberrant-regeneration-of",totalDownloads:104,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"A certain number of spontaneously recovering birth injuries to the brachial (BPI) plexus are known to be accompanied by muscle co-contractions (Co-Cs). The process of aberrant spontaneous regeneration contributes to the appearance of this phenomenon. Treatment strategies are mostly narrowed down to temporarily “switching off” the antagonist, allowing the agonist to perform. Less is known about the incidence of BPI-associated Co-Cs in adults (a-BPI), the control of which mainly presumes the extrapolation of a treatment strategy that has been shown to be effective in infants. Nowadays, surgical reconstruction of independent elbow flexion at BPIs relies heavily on redirection (transfer) of nerves that produce their own Co-Cs. These induced Co-Cs could potentially be reduced. Selecting the appropriate nerve transfer strategy (when the donor pool is narrowing), with its potential impact on the already complex and intricate global and segmental biomechanics of the upper extremity, becomes challenging. The chapter presents the anatomical background for the occurrence of muscular Co-Cs, a work on clinical classification of both regeneration associated and induced Co-Cs, possible surgical strategies, their benefits and limitations, in the presence of regeneration-associated muscle Co-Cs at a-BPI and clinical examples.",signatures:"Alexander A. Gatskiy and Ihor B. Tretyak",downloadPdfUrl:"/chapter/pdf-download/79557",previewPdfUrl:"/chapter/pdf-preview/79557",authors:[{id:"356896",title:"M.D.",name:"Alexander A.",surname:"Gatskiy",slug:"alexander-a.-gatskiy",fullName:"Alexander A. Gatskiy"},{id:"414397",title:"Prof.",name:"Ihor B.",surname:"Tretyak",slug:"ihor-b.-tretyak",fullName:"Ihor B. Tretyak"}],corrections:null},{id:"78600",title:"Frontiers of Brachial Plexus Injury: Future Revolutions in the Field",doi:"10.5772/intechopen.99209",slug:"frontiers-of-brachial-plexus-injury-future-revolutions-in-the-field",totalDownloads:68,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The field of brachial plexus surgery has undergone dramatic changes in the past 40 years. Most of these have been incremental in nature. We have seen increased use of nerve grafts and nerve transfers. We have seen the introduction of robotic limb replacements for the most severe flail limbs where surgical intervention has failed. In some cases, we have seen an increase in the use of computer simulation and virtual reality to train surgeons to plan and execute surgeries. More recently, we have seen the introduction of technologies derived from regenerative medicine research.",signatures:"Joseph M. Rosen, Jennifer Hong, Julien Klaudt-Moreau, Allison Podsednik and Vincent R. Hentz",downloadPdfUrl:"/chapter/pdf-download/78600",previewPdfUrl:"/chapter/pdf-preview/78600",authors:[{id:"354867",title:"Prof.",name:"Joseph M.",surname:"Rosen",slug:"joseph-m.-rosen",fullName:"Joseph M. Rosen"},{id:"354868",title:"Prof.",name:"Jennifer",surname:"Hong",slug:"jennifer-hong",fullName:"Jennifer Hong"},{id:"426471",title:"Dr.",name:"Julien",surname:"Klaudt-Moreau",slug:"julien-klaudt-moreau",fullName:"Julien Klaudt-Moreau"},{id:"426472",title:"Dr.",name:"Allison",surname:"Podsednik",slug:"allison-podsednik",fullName:"Allison Podsednik"},{id:"426473",title:"Dr.",name:"Vincent",surname:"R. Hentz",slug:"vincent-r.-hentz",fullName:"Vincent R. 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surrounding environment. To make justified and timely decisions for sustainable existence, reliable and detailed information about environmental parameters is inevitable.
\r\n\tWe need such information of the environmental indicators day and night, from the crowded cities and the most remote locations. Therefore the study, development, and application of automated sensing systems have been booming during the last decades and the progress in this field is really fast.
\r\n\tThe current book intends to provide the reader with the most recent trends in the development of sensing technologies for environmental control and monitoring, application of these novel technologies for the detection and monitoring of different environmental indicators, but also identification of hazardous chemical compounds and pathogens, and to introduce various aspects of using the online sensing data for decision-making in different fields of social life.
\r\n\t
History is important, present decisions can be concluded based on yesterday’s events. Just as a man values his memory, so the human race should value their history. Deductions from history enlighten the present mind, bringing about self awareness and historical exposure. History is indeed, “a roadmap that shows where you were from where you are and navigates you to the future”. It is a wonder to note that many people and society plan without taking history into cognizance. Consequently, most men have been thinking and doing things as if the world began today. The flagrant disregard of history has led to man’s inability to predetermine events and procedures, which makes man to continue to repeat his mistakes and suffer avoidable pains [1].
This book presents how Nigerians can start a journey towards industrialization; solve their myriads of problems, improve on its performance and save the failing nation from further collapse. It presents the experiences of other nations in promoting rapid industrialization; explains the scientific bases of the activities they carried out, and describes how these other counties have used their experiences to achieve industrialization and enhance their performance. History is indeed, “a roadmap that shows where you were from where you are and navigates you to the future”. It is a wonder to note that many people and society plan without taking history into cognizance. Consequently, most men have been thinking and doing things as if the world began today. The flagrant disregard of history has led to man’s inability to predetermine events and procedures, which makes man to continue to repeat his mistakes and suffer avoidable pains [1].
History shows that Britain and France spent 2000 years before achieving modern industrialization [2]. Here is an account of the positive changes which formed an intrinsic part of their evolutionary development voyage. Most pre-industrial European economies also had subsistence (as it is the case in Nigeria, today) standards of living among majority of the population. For example, in medieval Europe, a large percentage of the labor force was employed in subsistence agriculture. Increase in Poverty, Increase in population and escalated crime rates; during the reign of Henry VIII, approximately 72,000 people were executed for criminal offenses [3].
In the eighteenth and nineteenth centuries, massive increase in agricultural productivity due to the mechanization of agricultural processes was experienced by the United Kingdom, this experience was known as the British Agricultural Revolution. The British Agricultural Revolution enabled and freed up a significant percentage of the workforce from farming and helping to drive the Industrial Revolution. Increase in steel works and Demand for more machinery was increasing, job opportunities also began to increase [4]. The overwhelming efficiency of mechanized farming made the increased population not to be dedicated to agriculture. The process of production was divided into simple tasks, each one of them being gradually mechanized in order to boost productivity and thus increase income. The application of new technologies enabled the industrialization process to continue to evolve. Industrialization is the replacement of hand tools by machine and powered tools by a society. Industrialization also involves vast economic and social changes, e.g., a tendency towards urbanization, a growing body of wage earners, increased technical and advanced education [5].
In 1938, a ship-building yard was established and engineering works began. In 1939 the corset iron company started a steelworks. France, Germany, Sweden and other European nations had similar experiences and Britain had a single digit unemployment rate of 4.0% (tradingeconomics.com) and the ability of their economy to absorb labor increased [6].
In Singapore’s case the most feasible solution to their low economic development and high unemployment rate was to embark on a bold and comprehensive program of industrialization. Labor-intensive industries were a prime target. However, industrialization was a relatively new experience to Singapore because they had no industrial tradition. Both capital and entrepreneurship had historically been active in trading and commercial activities. The working population in Singapore focused mainly in trade, processing and service activities [7].
The Economic Development Board (EDB) of Singapore invested in manpower development, being an investment promotion agency? They work with other relevant government agencies, skills and technologies. In 1971, an Overseas Training Program for Singapore workforce was established by the EDB for training in industrialized countries and subsequently, technology and design training institutions in Singapore and other foreign countries. Additionally, to encourage the right kind of manpower training, the EDB administers the Skills Development Fund and promotes the opportunity for the trained to apply the acquired knowledge and this paid off, because they currently have an unemployment rate of 2.20%.
The need to develop a highly learned and versatile workforce is very important, and Singapore has been preparing its human capital by developing a wide pool of skilled knowledge workers. The outcome of all these developments is rapid economic growth and full employment.
Singapore emphasized the increase on R&D and the installation of high technology based industries, this restructured industries [8]. This brings about product diversification which is crucial in enhancing sustained export performance and growth. There are two engines of economic growth identified in the restructuring process in Singapore: manufacturing and services.
Studying the case of America, Colonies gained independence in 1783 just as industrial productions and coordination’s were beginning to shift production from handmade to machine made. The Industrial Revolution (1820–1870) was significant to the economic development of the United States. The Industrial Revolution itself refers to a change from hand and home production to machine and factory production.
People in the Pacific Northwest practiced food preservation although substantial agriculture, built wooden houses, used nets and weirs to catch fish, and was not developed [9]. Throughout the colonies, people were self-sufficient, they lived primarily on small farms and in the few small cities and among the larger plantations, some necessities and virtually all luxuries were imported in return for tobacco, rice, and indigo exports [10].
A unique confluence of geographical, social, and economic factors facilitated American industrialization. The passage of the Embargo Act of 1807 and the War of 1812 was the real impetus for America entering the Industrial Revolution. The British opened fire when they were not allowed to search the Chesapeake ship and this made Americans upset. The desertion caused from seizing four men and hanging one of them resulted in much public outrage and the passage of the Embargo Act which stopped the export of American goods and effectively ended the import of goods from other nations. Eventually, the war with Great Britain in 1812 made it apparent that America needed a better transportation system and more economic independence. The manufacturing industry began to expand and employment began to boom [11]. This gave rise to increase in productivity and ability of the nation to absorb labor.
Small local industries such as sawmills and gristmills emerged as the colonies grew and standard of living generally increased [12]. However, the people involved were small in number which in turn slowed down their rate of technological change and advancement [9]. To check this, everybody including children worked in large numbers in mines, glass factories, textiles, agriculture, canneries, home industries, and as newsboys, messengers, bootblacks, and peddlers. The industrial processes were able to keep the unemployment rate to 3.70%.
Sustainable Economic Growth, Industrialization and Development (SEGID) are achieved through learning. The value of the “learning-man” appreciates in a compound fashion with learning intensity and time [12]. So what does learning involve? Stahl [13] observed that learning begins from the novices’ position and progresses to the experts’ position. This in turn creates relatively permanent changes in knowledge, skills and other behaviors [14]. Thus, when a person commences an educational or apprenticeship program, he or she usually begins from the minimum level. At the end of the first year of learning, the learning-person is promoted to the second level having learnt the things scheduled for the first level. The growth achieved this way is sustainable [15]. The learning person builds up capabilities or competence i.e.
If this is what learning involves, what then is the benefit of learning? Drucker [16] said that only man is capable of enlargement, because man grows, develops and acquires skills, and individuals can learn a specific type of knowledge, and the amount they learn is cumulative [17]. Learning and acquiring knowledge, skills, and capabilities and applying these in solving problems, including production, are the basis for achieving sustainable economic growth and industrialization [18].
Education and training are both essential arms of the learning process. But then, Ehiametalor [19] suggests that a clear path between education and training is very important for successful manpower planning. Formal education emphasizes on the acquisition of theoretical knowledge and the development of basic mental capabilities and general knowledge. Education, according to Coombs [20], is institutionalized instructions or course of study designed to make the learning persons, or student, experience the type of curriculum that is capable of providing essential learning needs. Education equips the individual with the ability to think and reason. Nyerere [21] considered education to be an instrument for effecting economic and technological change, change in ideas and personality. The essence of education is in developing critical thinkers and enhancing performance.
Coombs [20], however, defines training as a scheme designed to generate expertise or skills needed to perform a particular job or series of jobs. Kanawaty [22] observed that training prepares people for work and life-skills are largely developed in a working situation; competence develops through improvements of awareness, knowledge and skills. These work skills are of three types: technical, interpersonal or human and conceptual skills [23]. These skills are obtained through learning. That is, from “learning-by-doing” and “learning-by-adapting” to “learning-by-design” and “learning-by-improved design” and then to “learning-by-setting-up a complete production system.” [24].
Policy is a guide to thinking and action [25]; policy guides every thought process and activity undertaken in a society. Therefore, Nigeria must carefully consider its science and technology policies to guide the way we think and act.
Policies will not be successful if they do not go through the formulation stage, the implementation stage and the evaluation stage [26]. Policies once formulated, tend to become doctrines and models; they direct and justify action for some time, hence they should not be entered flimsily.
The knowledge and understanding that the scientists have about the world is often represented in the form of models. This scientific method is basically one of creating, verifying, and modifying models of the world and the goal is to simplify and explain the complexity and confusion of the world. The applied scientists and technologists then use the models of science to predict and control the world.
Discussing the journey to industrialization requires an emphasis on the desire to achieve industrialization, the desire to improve work performance and the desire to acquire knowledge. These models represented in this chapter would have no effect if there is an absence of genuine desire.
Each model discussed in this chapter represents a policy statement for personal and economic development. The policy statements were adapted from developed countries and modeled for easy interpretation and understanding. Nations must realize that attaining industrialization transforms the economy from a dependent state to an independent one, even further more to an interdependent state. Hence, the importance of these models for personal growth, economic development, performance enhancement and industrialization cannot be over emphasized. Therefore, to grow into a dependent or interdependent state, an individual or country needs to improve their manufacturing and service performance.
Every developing nation must know why and what to do to achieve that development and also know how best to go about achieving such an endeavor. It is good to understand that real growth and development do not take place suddenly; the price must be paid over an extended period of time in order to reap the benefits for a long time.
The following models offer insights on the concept of industrialization and performance enhancement. There are models that guide developing nations on the path to industrialization and models that transform individuals to become active creators, learned and productive.
Before a nation attempts to be industrialized, there must be proper groundwork: research. This means a nation must undergo proper planning and forecasting. However, before a nation can plan, they need to have a direction, a goal and a vision. That direction must be well stated. This model emphasizes the need for sustaining values, having a unifying language, goal, purpose or creed to form a seamless boundary to curb tribalism, individualism, terrorism, nepotism and religious segmentation. Invariably all Africans should resolve in their hearts saying,
Let the vision be in a form of multiyear development plans. These multiyear development plans can make the attainment of economic development easier and faster. They can form a positive norm in the hearts of the citizenry, improve their performance and gear them towards productivity.
This creed, when said often becomes the subconscious language of the citizens. The citizens become a group of people who through their oneness of mind and language are able to achieve whatever they planned to do.
This creed is a guide and mandate that everyone must uphold, and it is a language everyone must speak. By so doing, it promotes unity and oneness. At this point, everyone would understand that although they have diverse cultures and tongues, they are one through the attainment of this creed.
A productive Citizen is one who has the ability to think and act respectively. In order to make productivity a lifestyle, citizens must be constantly thinking of new ways and seeking the slightest opportunity to apply those new ideas. The mind is the best creative tool. What flows into the mind is definitely what is expected to flow out. The mind helps to create a thinking atmosphere for new ideas and provides the ability for application. Each thought creates a neuron, each neuron directly and indirectly formulates a policy.
The mind power is the first tool to promoting sustainable growth, development and industrialization. The potential to think and improve the world around us is directly dependent on the level of knowledge or exposure attained – conceptually, technically and human relations. The true measures of any society or any individual is not what it knows but what it does with what it knows.
We have been made to constantly think that foreigners are better than us. We have harnessed this thought so much, creating millions of neurons and automatically is seems the foreigners are truly better than us.
Observing the historical experiences of Europe, America, Singapore and other developed nations, five factors are noted as key contributors that promoted their performance and industrialization process;
Manpower Development,
Employment Creation
Increased Productivity
Inventions and Innovations
Increased Learning Rate
These factors as presented in Figure 1 either grow or reduce the industrial core. It was observed that a nation which hopes to manufacture many products must develop the people to manufacture them. These people developed are referred to as the nation’s workforce or manpower. Developing nation’s especially African nations need to set up a framework for training university graduates in a curriculum-based scheme for 4 years, so as to acquire the skills to modernize and repackage their traditional activities and for studying, servicing, maintaining, duplicating, and eventually improving upon the things they import today.
Sustainable industrialization initiators.
Nigeria and other African nations need to encourage, support and give opportunities to science and engineering graduates to input the theories they acquire in universities into their artisan/craft activities like blacksmithing, wood-works, textiles/tailoring, construction works, and factory floor work settings and all other places where skill acquisition opportunities abound. This is how the countries can improve performance and produce youths that can develop independent thoughts to solutions about everyday problems. These youth shall evolve to become Industrialization Vanguards (IVs). Their Productivity increases as they develop manpower capability and are employed into productive activities. This in turn creates more room for employment through expansion, and as they continually involve themselves in productive activities, inventions/innovations sprout out and these inventions/innovations form the basis for new knowledge.
Industrialization is not about erecting structures, it is about developing competencies and improving performances for doing uncountable things. It is about ensuring a large percentage of resource is geared towards manpower development, employment creation, increasing productivity, promoting inventions and innovations and increasing the learning rate of the citizens. Industrialization is an all-encompassing process, it equals productivity and development. Actualization can be attained when industrialization, development and productivity are growing exponentially. Figure 2 explains the components of the industrial core.
Components of the industrial core.
The industrial core consists of simple parameters that must not be overlooked. Figure 2 shows the components that make up the industrial core. The industrial core is made up of two layers: the INTERNAL CORE and the EXTERNAL CORE.
The internal core includes the primary, secondary and tertiary industries. The primary industry also known as the extractive industry deals with the extensive extraction of natural resources without provision for their renewal. The primary industry is key and fundamental for the effective existence of both the secondary and tertiary industries. The secondary industry is the manufacturing industry as it deals with the process of converting raw materials in components or parts with the use of machines, into finished goods that meet a customer’s expectation or specifications. The tertiary industry which is also known as the service industry serves other industries. This basically refers to the intangible products that are important to the primary and secondary industries.
The external core constitutes the decisive environment such as the percentage utilization of libraries, educational centers, information technology centers, scientific research findings, cultural uniqueness of the citizens. The integration of all these into government policies go a long way to determine the kind of industries, level of industrialization, performances and growth prospects available. Below is a list of industries classified in their particular sector.
Being ready for industrialization depends on the effectiveness of the components within the industrial core. An economy or an individual must first be familiar with the components within the industrial core before the industrialization process is initiated. That economy must clearly have a reason for industrialization and know how to go about it. This is the journey the nation needs to embark on to prepare for industrialization. This process is not a waste of time and this stage holds all the fundamental elements for development. The level of preparation determines the outcome that the nation hopes to achieve. At this phase policies are set, decision are made, objectives are outlined, plans are arrayed, resources are weighed based on availability and capacity of use, forecasts are determined and a focus is outlined. A country can only be ready for development when all these are sincerely and truthfully harnessed.
From history we can deduce that there are three true measures of sustainable economic development and performance enhancement. They are: 1) the level of technological knowledge, 2) the level of industrialization and 3) the level of national productivity. As shown in Figure 3, these three true measures are intertwined.
The three true measures of economic development.
An increase in the level of technological knowledge through learning spurs increased national productivity through employment of a workforce that possesses technical knowledge. In turn, more industries would be established to utilize the knowledge and productivity in order to meet demands and exportation. As this cycle continues, the economy experiences sustainable growth and development and industrialization sets in. Industrialization is the extensive organization of an economy for the purpose of manufacturing. It introduces a period of social and economic changes that transform or liberates a human group from an agrarian society into an industrial one.
Historically, industrialization processes involves the expansion of the secondary sector in an economy originally dominated by primary-sector activities. The lack of an industrial sector in a country can slow growth in the country’s economy and power, so government often encourages or enforces industrialization. These series of activities should lead to increased productivity, increased manpower that possesses technical knowledge and a high industrial cluster in all sectors.
Manpower is that portion of the population which has actual or potential capability to contribute to the production of goods and services. They make up the workforce of a nation. The Manpower Development Learning Model has three key components that help initiate an efficient and effective workforce, as shown in Figure 4. These components are 1) education (the theoretical part of Learning), 2) Training (the Practical part of learning) and 3) Age (experience and Timing).
Manpower learning model.
A workforce that possesses a high composition of theoretical, practical and experiential knowledge can catalyze and experience greater productivity, increase in technological application, high performances and generate innovations. Industrialization can only strive where such a workforce exists. For an economy to achieve sustainable development there must be an increase in the level of industrialization, an increase in the level of national productivity and an increase in the level of technical knowledge.
A nation’s workforce must therefore concentrate on increasing productivity and acquiring more technical knowledge through research and development to spur innovations. The process of acquiring such intellect is known as the Manpower Development process and the manpower learning model is a guide to effective acquisition of the knowledge. The three major components of the model, education, training, and age, are discussed below.
The higher the university education completion rate, the higher the share of knowledge that intensive service industries receive. The Knowledge Intensive Service Industry provides consumers with knowledge – based services, mainly relying on high technology, expertise, information and experience. The service process includes knowledge production, knowledge dissemination and knowledge use. The knowledge Intensive Service Industry is supported mainly by science, engineering, technology and other industries. The education and skills of the labor force have been recognized to be the underpinnings of innovation.
Innovation is possible if there are people who can perform research that generates new ways of thinking and new knowledge, who can apply their knowledge and skills, and who can adapt to change. Therefore, the workforce must aim at attaining a high theoretical knowledge, especially science and engineering graduates. Simultaneously, s/he must receive complementary training and skills based on their age and educational attainment. A workforce should be encouraged to pursue a university degree, alongside complementary training/skills. Education helps to build the technical, interpersonal or human and conceptual skills of the workforce.
Coombs [21] defines training as a scheme designed to generate expertise or skills needed to perform a particular job or series of jobs. Kanawaty [23] observed that the training that prepares people for work and life skills are largely developed in a working situation; competence develops through improvements of awareness, knowledge and skills.
Training skills range from soft skills, basic artisan skills to advanced technical skills. Training must be practical and must complement educational (theoretical) knowledge. Training begins when a child is born, with soft skills and goes through from basic artisan skills to advanced professional skills.
Soft skills build character; they help develop the character traits of a person and they help define their personality. Everyone needs soft skills to prepare them and maintain a healthy working attitude.
Soft skills can be learnt at any age, but the nature of these skills suggests that they are best learnt at a very young age because they are foundational. Soft skills build the competence and confidence of the labor force, giving room for more achievements.
Soft skills range from learning diverse languages, presentation skills, drawing skills, writing skills, reading skills, music skills, ethics and etiquettes, etc. These skills improve creativity. This skill will enable the workforce to create sustainable enterprises and visionary companies. Soft skills are critical for the foundational setting of the workforce. They can provide great energy and cohesion for the members of the workforce.
An artisan is a craftsman, someone who does skilled work; making things with his hands, manually. The artisan skills range from woodland crafts, building crafts, field crafts, workshop crafts, textile crafts and domestic crafts.
Woodland crafts
This includes coppices, hurdle makers, rake makers, fork makers, besom makers, handle makers, hoop markers, ladder makers, crib makers, broaches and peg makers, clog sole cutters, charcoal burners, oak basket makers, stick and staff makers, field gate makers, willow basket makers, and net makers.
Building crafts
The builders include stone masons, plumbers, decorators, bridge builders, French polishers, and sign writers.
Farmers
This includes hedge layers, stile makers, well diggers, peat cutter, gardeners, horticulturists, tree surgeons, foresters, farmers, shepherds, shearers, bee keepers, millers, fishermen, orchardist, and veterinarians.
Workshop crafts
This includes chair makers, iron founders, black smiths, wheelwright, coopers, coppersmiths, tinsmiths, wood turners, coach builders, boat builders, boiler makers, boiler men, soap makers, gunsmiths,, clay pipe maker, and tool maker.
Textile crafts
This includes spinners, weavers, dryers, silk growers, tailors, seamstresses, milliners, hatter, lace makers, button makers, mat and rug makers, crochet workers, tatting and macramé workers, knitters, quilters, smock workers, embroiderers, leather workers, and felt makers.
Domestic crafts
Fish smokers, bacon curers, dish wash maker, insecticide makers, butter makers, cheese makers, brewers, cider makers, wine makers, distillers, herbalists, ice cream makers, bakers, barrister and coffee roasters, osteopaths, naturopaths, story tellers, teacher, naturalists, historians, jesters, actors, administrators, philosophers, laborers, poets, writers, midwifes, publicans, booksellers, Liberians, movie makers, public speakers, etc.
Advanced skills are necessary for the mechanization or automation of artisan skills and the production of other advanced products not possible by craftsmen alone. Advanced skills include qualitative analytical forecasting skills, military training, leadership skills, teamwork and management skills, policy formulation and advocacy skills, wafer fabrication, Integrated Circuit Design, biotech, making petrochemicals, fine chemicals, pharmaceutical, automotive machines and cybernetics, aerospace, computer aided design tools and other precision engineering components.
Advanced skills involve a lot of research and development and are important to bring about innovation. Innovation improves and increases productivity, spurring industrialization and economic development. An advanced skill is a must-have collection of activities for advanced level students. The advanced training of workers is carried out through individual and team training, both on-the-job and in a variety of short courses. Such training is offered by institutes for improving the skills of managerial personnel and specialists. Advanced training does not usually require taking time off from work.
Therefore an “expert manpower” is one who has attained proper education and had been trained to an advanced professional technological level; integrating both theory and practice to improving productivity and promoting industrialization.
Every human being requires the opportunity to listen, teach and apply what they have learnt to productivity. Most of them do not know when to perform each of these activities, hence the need for the guide as represented in Table 1.
Age | Listening | Teaching | Application | Total |
---|---|---|---|---|
0–5 years | 85% | 05% | 10% | 100% |
6–19 years | 55% | 15% | 30% | 100% |
20–60 years | 30% | 30% | 40% | 100% |
Above 61 years | 30% | 60% | 10% | 100% |
Human activity valuation model.
Source: Author, 2014.
Listening is associated with the acquisition of theoretical knowledge, Teaching is associated with mentorship, raising successors and transferring values to younger generations. Application is simply the acquisition and utilization of practical knowledge.
Studying developed nations resulted in designing the Development Flow Chart, as shown in Figure 5. Studying the models of developed countries on how they scaled through the process of industrialization, we can identify various stages that promoted and sustained their ability to do so. These stages include; Preparation, Learning, Productivity and Networking of scientific ideas.
Development flowchart.
This flow chart shows the importance of Preparation. Although the United Kingdom went through industrialization process without preparation, it started out of curiosity. This curiosity-driven industrialization process lasted for a long time before actualization but studying other countries like America, Singapore and the Newly Industrialized Countries (NIC) we see the elements of planning and preparation and industrialization were achieved in less than 50 years.
The developed countries had to prepare for development; hence the precursor was a decision for industrialization. Before a child is born, the parents get ready for the arrival of the baby. In the same way, before a country becomes industrialized, the country must prepare for the industrialization process.
The nation needs to setup policies to get them ready for industrialization. The nation needs to be willing to be industrialized, the nation needs to start up a chain reaction that leads to industrialization and get to a state of readiness, especially for industrialization.
From history, it was observed that learning was taken very seriously by the industrialized nations. For example, a developing nation could be likened to a growing child. A baby sits and observes, recording everything everybody does and then begins almost immediately to do likewise. The baby who depended on others to always hold her now runs on her own. That child that could only babble now speaks clearly. It is good to know that the child has been developing. No parent would be happy if their child, after two years, has failed to speak and walk. How does a child achieve all these activities? Learning!
Learning is the second stage as shown in Figure 5, and it comes in different forms; Learning-by-doing and learning-by-adapting, learning-by-design and learning-by-improved design, and learning-by-setting-up a complete production system [24]. People do not learn by-letting experts do everything for them. If so, they will continually be slaves to the expert who knows and the learner will lack the opportunity to become an expert.
The third stage is Productivity. A developing nation needs to acquire knowledge and that knowledge obtained should be mandatorily applied in productive activities to increase the total performance and value of goods produced and services provided within a year. The use of this knowledge obtained improves the effectiveness of the production, i.e. being able to produce quality amounts of goods, and services, etc.
The fourth stage is Networking/Synergy. The term synergy comes from the Greek word
Nations or individuals that intend to adopt the Development Flow Chart, also known as “YOUNG’s MODEL,” must first prepare themselves for development. Any man that follows this path is on the right path towards development. If not, it is dearth (starvation, Poverty and Lack).
The developing nations have lately been focusing on fostering the spirit of entrepreneurship in the hearts of the citizens. This is a good move, but the right kinds of entrepreneurs need to be developed. This book concentrates on two kinds of entrepreneurs that promote industrialization and growth; the technological entrepreneur and the commercial entrepreneur.
The technological entrepreneur is a producer who is involved in a considerable amount of research and development and his activities greatly promote industrialization, see Figure 6.
Schematic presentation of a technological entrepreneur.
Technological entrepreneurship requires innovative skills for the creation of new products, new production methods, discovery of new sources of raw materials, opening of new markets and creation of new forms of organization [27].
Technological entrepreneurs are the right kind of entrepreneurs every developing nation requires. These are the kind of entrepreneurs you need to breed; those who enjoy innovation and production; those who enjoy mixing different procedures and processes; those who love creativity.
Technological entrepreneurship aims at creating new products, designing new production methods, discovery of new sources of raw materials, opening new markets and developing new forms of organizations through innovative skills. The performance measurement for these entrepreneurs include; number of innovation, number of new markets and number of new market products, number of new raw materials, of new production process, number of new forms of organization.
Commercial entrepreneurs aim at creating profitable operations resulting in private gain. The performance measurements for these entrepreneurs include; financial indicators, market share, customer satisfaction and quality. Figure 7 is a diagrammatic representation of Commercial entrepreneurship. The producer determines how much the entrepreneur sells, and the time, quality and quantity of the goods to be sold. If the producer decides to pull out from that market the commercial entrepreneur is automatically knocked out of business.
Schematic presentation of a commercial entrepreneur.
The commercial entrepreneur is totally dependent on the producer. He is usually referred to as the lazy entrepreneur. He is not involved in productive activities. His research, development and innovative activities shall be limited to market and organizational innovation. All he needs to do is study a market; find out their need or the product demand of the market, link with the producer of such product and act as a middle man who suppliers the needed product to the market. The entrepreneur buys from the producer and supplies the market, simple!
However, the risk involved in being a commercial entrepreneur is far too great. We need both technological entrepreneurs and commercial entrepreneurs because when production meets distribution we attain optimum consumption and standards of living increase. It is paramount we have more technological entrepreneurs to boost economic productivity, because an increase in economic productivity increases economic strength, growth, development and industrialization.
A manufacturing revolution has emerged in the past 50 years that is as significant as the industrial revolution of the 19th century. The industrial revolution, which captured the introduction of radically new production technologies diffused across the globe and has fundamentally affected the nature of global production, birthed the manufacturing revolution.
Limited knowledge and ability of its people to create new innovations are the greatest challenges facing industrial process in developing nations. Failure to continuously strengthen and increase our knowledge base will surely result in a declining ability to provide for the needs wants and of our people. When increased productivity is viewed as a generator of wealth, the importance of innovation is clear. Employment opportunities in many industries will increase tremendously as productivity increases. Indirect employment will be created as well.
Moves towards industrialization are scarce and hesitant in developing countries. This is as a result of the copy and paste policy syndrome from industrialized nations by developing nations, without knowledge that there is no general rule or prescriptions for industrialization change. Policies should be specifically tailored to the capabilities of the particular country with more selective options requiring the highest levels of capabilities.
Simply put, these two challenges namely; (1) limited knowledge and knowledge acquisition processes, and (2) the poor policy formulation process are the main causes of Africa’s problems. They are both associated with our thinking process and it’s been proven that our actions are fruits of thoughts. When these challenges are tackled, a smooth journey to industrialization for developing nations like ours would be ensured.
Historically, a large majority of the citizens of developing nations were denied the benefits of the industrial revolution. Many of them were cheap slaves and contractual servants; thus robbing them of their uniqueness, self-esteem, poise and confidence.
However, despite the change in state of affairs; with developing nations gaining a greater measure of freedom and independence, many of the citizens of developing countries are still struggling with their uniqueness and their sense of self-worth. Many of the nations that progressed and developed through the industrial revolution have reinforced (by attitude, policies, and legislation) the notion that the citizens of developing nations do not possess the potential to develop the skills, intelligence and sophistication necessary to equal that of industrialized nations.
The developing nations in effect are led to still look to the industrially developed states for their measure of standard, quality and excellence. This in turn breeds a sense of disrespect and suspicion for their own products and a denial of the great potential that lies dormant in the citizens of developing nations everywhere. There is still the notion that the presence of a foreign element is necessary for the maintenance of excellence and quality. This is not true! Citizens of developing nations are great; they possess the intelligence for transformation and the sooner we realize this truth and believe in our ability to stimulate the industrialization process; only then will the journey to industrialization begin.
We acknowledge and appreciate Awojobi Anthonia, Abang Scott, Obaze Irene, Ryan Sherry, Nnachi Joseph and Ojuloge Blessing for their support.
This chapter would not have been possible without the keen interest of our friends and the crew who, all through our life, has experienced our little victories, defeats, and believed and held fast to the simple theories we emerged.
But most of all, this chapter is for our mentors, partners and protégés too numerous to mention. And to you reading this, we say thank you for supporting sustainable economic growth, development and industrialization.
Thank you for embracing performance enhancement principles.
To truly appreciate the history of our understanding of macrophages, we must first understand how macrophages manifest from earlier cellular lineages. Just as humans have common ancestors and lineages with other primates, so too do macrophages with other cells derived from myeloid progenitor cells. All this is to say, just as humans are complex organisms, macrophages have fantastic intricacies and potential fates. The whole world is its oyster, or petri dish, if you will.
So, how do macrophages come to be? We’ll go over some key points here, and some will be expanded upon in subsequent sections within this chapter. Discussion in this chapter will pertain to macrophages, monocytes, and fibroblasts in a broad cellular sense but will also have a focus on human physiology. Briefly, macrophages comprise a heterogenous and highly variable group of myeloid cells that function within the innate immune system [1]. The functions of macrophages are largely attributed to inflammation, which will be discussed further below.
What makes macrophages particularly fascinating is the plasticity of their manifestation. In other words, macrophages have the innate ability to alter their phenotype during development in response to, and in conjunction with, myriad environmental signals [1]. This plasticity in “activation” of macrophages is a growing area of research in fields such as immunology, disease progression, tissue and extracellular matrix homeostasis, and resolution of inflammation [2].
More specifically, the activation of macrophages can come about by stimuli such as cytokines—special cellular signaling proteins—that influence levels of gene and protein expression [2]. The unique composition of cell surface receptors, intracellular enzymes, and cytokines allows us to create distinctions that organize our understanding of macrophage activation.
The exact categories of macrophage activation go beyond the scope of this chapter, and such distinctions are still a point of ongoing scientific discussion. However, for the purpose of our understanding, there are two primary routes of macrophage activation. The first is commonly known as “classically activated” or “type 1” macrophages (M1), and the second is known as “alternatively activated” or “type 2” (M2) [2]. These states of activation have been described as polarized extremes within a continuum of macrophage functionality [3]. Indeed, various subsets of nomenclature have been established, such as M2a and M2b, that expand upon the basic M1 and M2 classifications, accounting for the possibility of activation within a spectrum of phenotypes [2]. For the purpose of this chapter, we’ll delve deeper into M1 and M2, bearing in mind the continuum within which we are exploring.
Classically activated macrophages are purported to be involved in the canonical response to tissue injury and/or infection. As expected, this pathway of activation is characterized by macrophage expression of many pro-inflammatory cytokines, such as TNF-α, and interleukins such as IL-1β, IL-6, and IL-12 [1]. These M1 macrophages are heavily involved in the inflammatory cascade discussed in subsequent sections within this chapter, primarily through the production of reactive oxygen and nitrogen species [1].
Alternatively activated macrophages, in contrast to M1 macrophages, secrete minimal pro-inflammatory cytokines [1]. Instead, M2 macrophages secrete numerous anti-inflammatory cytokines such as IL-10, CCL18, and CCL22 [1]. Further, alternatively activated macrophages play a crucial role in counteracting pro-inflammatory and cellular immune mechanisms, with inhibitory and regulatory functions in such pathways [4]. In this respect, M1 macrophages are broadly categorized as the pro-inflammatory side of the spectrum, whereas M2 macrophages pertain mostly to the anti-inflammatory side of the spectrum [1].
Though more complicated than necessary for the purpose of discussion in this chapter, there are various
To conclude our introduction to the manifestation of macrophages, it should additionally be noted that IL-10 is a much more complex cytokine than previously thought. Difficult to describe and fully encapsulate in experimental data or scientific publications, IL-10 can behave as both a pro-inflammatory and anti-inflammatory cytokine in various environmental conditions [6, 7]. With the presence of IL-10 during the developmental process of macrophages, it is exciting to consider that there is potentially still much to learn about macrophages, and that our history of understanding these cells continues into our future.
Now that we understand a bit more about the manifestation of macrophages, let us now turn our attention to the myeloid cells from which macrophages are themselves derived—monocytes. Monocytes are another complex and intriguing cell type and will be one of our focuses for the bulk of this chapter. However, it would be inappropriate to discuss the functions and fates of monocytes without also discussing the role of another cell type involved in would healing—fibroblasts. Fibroblasts are largely involved in the structuring and maintenance of the extracellular matrix (ECM) of tissue and play a vital role in the wound healing process.
In most human tissues, healthy wound healing is predicted to occur following hemostasis (blood clotting) via orderly and efficient progression through various stages of a signaling cascade (Figure 1). These stages include local inflammation, inflammatory resolution, tissue cell proliferation, and tissue remodeling [8]. Fibrosis—the formation of dysfunctional and often distorted scar tissue—occurs when these sequential events are dysregulated by dynamic signaling pathways [9, 10].
Signaling cascade following hemostasis during wound healing. Progression through these stages, either subsequently or in an overlapping fashion, leads to the healthy remodeling of tissue. Dysregulation at various points within this cascade can result in aberrant wound repair, as is seen in fibrosis.
The inflammatory phase of wound healing is when circulating monocytes, as well as neutrophils, infiltrate tissue at the site of injury via cytokine recruitment [8]. Upon arrival, these circulating monocytes, in addition to local tissue monocytes, may differentiate into tissue macrophages (Figure 2) [8]. Classically or alternatively activated macrophages then play a role in tissue debridement, phagocytosis of foreign particles, and interaction with other cell types at the wound site such as fibroblasts and lymphocytes. This communication is in the form of secreted cytokines and growth factors, such as platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and transforming growth factor β (TGFβ) [8]. Macrophages also play a role in antigen presentation for T-lymphocytes for development of downstream memory immune responses [8]. Without the vital role of macrophages, there would be slowed growth of damaged tissue, persistence of cellular and particulate debris, and slowed progression through the subsequent stages of wound healing (Figure 1).
Schematic of the central role of macrophages in wound healing. Circulating monocytes that differentiate into macrophages, in addition to tissue resident macrophages, can be classically or alternatively activated. Activated macrophages then contribute to various processes associated with wound healing. Cellular crosstalk between monocytes, macrophages, and stromal myofibroblasts further contributes to the complexity of the wound repair process.
The plasticity of activated macrophages is quite impressive. The elegant balance between classically and alternatively activated macrophages is crucial for preventing pathologies or acute reactions within wounded tissue [11]. This balance is made possible by the macrophage phenotypic plasticity; classically activated macrophages within the wound site can kill pathogens, neutralize toxins, and debride the wound [11]. In turn, alternatively activated macrophages are recruited via cytokines to repair tissue and heal the wound [11]. To prevent recruitment of circulating monocytes beyond this point, classically activated macrophages can switch their apparent phenotype to alternatively activated macrophages, based on signals from the local stromal tissue (Figure 2) [11]. This interesting signaling between stromal tissue, macrophages, and circulating monocytes will be discussed further later in this chapter.
In many human tissues, wound healing initiates the TGFβ signaling pathway, distinct from macrophage-secreted TGFβ [10]. Exposure of tissue fibroblasts to TGFβ induces another type of cellular activation. In this situation, tissue fibroblasts can become activated into myofibroblasts, characterized by expression of α-smooth muscle actin (α-SMA) [8]. Myofibroblasts play a prominent role in wound healing by synthesizing and secreting large quantities of ECM material, and additionally obtain a phenotype of increased contractility. The ECM secretions and increased contractility of these cell types facilitate wound healing, though excessive levels are characteristic of tissue fibrosis [8].
The magnitude and duration of the proliferative stage of wound healing is correlated to the duration of the inflammatory phase [12]. Indeed, the amount of collagen deposited by myofibroblasts can be reduced by attenuating the inflammatory response [13]. During remodeling, fibrovascular tissue formed during the proliferative stage matures into scar tissue [12]. Normal reduction in myofibroblast numbers through apoptosis is important during this ECM remodeling, and prolongation of myofibroblast survival leads to excessive scar tissue formation [12].
Before moving to the next section of this chapter, let us connect these concepts and ideas surrounding cell types to form a clearer picture for our understanding. It certainly wasn’t an exaggeration on my part when I described monocytes, macrophages, and fibroblasts as complex cell types! In a vacuum, each of these cells can behave in unique ways, demonstrating variable phenotypes even when assessed individually as a mono-culture of cells. This is a focal point of many
The canonical understanding of wound healing involves the “forward talk” from circulating immune cells to stromal cells, such as fibroblasts, to induce paracrine signaling or activation of these fibroblasts into myofibroblasts [8]. Indeed, it has long been accepted that the processes of monocyte recruitment, differentiation into classically or alternatively activated macrophages, and signaling to fibroblasts follow an organized and stringent process [14]. However, our general understanding is somewhat lacking when considering the “back talk” from stromal cells to monocytes, and the effects of this communication on monocyte cytokine production and downstream macrophage differentiation (Figure 2).
As a brief aside, a commonly used cell line for assessing monocyte cellular processes is the THP-1 cell line. THP-1 cells are immortalized human monocytes derived from an acute monocytic leukemia patient [15]. These cells are invaluable because they potentiate a simplistic but widely available
However, as is the case with many
Previous studies have shown that gene expression in THP-1 monocytes encoding macrophage differentiation markers is influenced by co-culture with fibroblasts [16]. However, there are currently few studies of this type that assess the relative effects of co-culture on both cell types, particularly in the context of wound healing. Could it be the case that multiple cell types influence each other’s behavior in cell culture? Let us explore this for a moment.
As outlined earlier, fibroblast activation into myofibroblasts is largely induced by mechanical properties of the ECM through various mechanotransduction pathways [14]. Strain caused by fibroblast focal adhesions within the collagen meshwork of the ECM enables efficient mechanical activation of latent TGFβ1 through integrin-mediated cell-pulling [14]. Increased TGFβ1 signaling can then induce further fibroblast activation into myofibroblasts in a positive feedback loop. As well, myofibroblast activation facilitates active ECM remodeling during wound healing, producing mechanical cues for other cell types such as circulating blood monocytes [14]. Such signaling characterizes the “back talk” from ECM myofibroblasts to monocytes. Erroneous and persistent communication from ECM signals to monocytes can promote further myofibroblast activation and fibrosis [14], characterizing a feedback loop of “forward talk”. Thus, a 3D cell culture model that closely resembles physiological ECM would likely be most appropriate for the assessment of myofibroblast activation via TGFβ1 signaling pathways.
That there have been relatively few studies assessing the relative effects of co-culture on circulating monocytes and fibroblasts is unfortunate. It is troubling because of a phenomenon previously demonstrated via
All this is to say, there are complex cell-cell interactions between stromal fibroblasts in a 3D ECM and circulating blood monocytes. Indeed, stromal cells, specifically fibroblasts, are becoming increasingly prominent in research regarding pathogenesis of tissue inflammation, immunomodulation of tissue microenvironments, transition from acute to chronic inflammation, and inflammation persistence associated with rheumatoid arthritis [19]. In this context, fibroblasts play a functional role in the progression of chronic inflammation, in addition to their role in tissue fibrosis highlighted earlier.
Beyond involvement in chronic inflammation and tissue fibrosis, fibroblasts and stroma in a broad sense play a functional role in another chronic pathology: malignant disease. In this instance, stromal cells lay down the components of the non-tumor ECM that potentiates growth of solid tumors [19]. However, stromal cells can also be a key driver of tumor progression through the inhibition of apoptosis in malignant cells in breast carcinoma [20]. Further, stromal cells and cancer-associated fibroblasts are purported to facilitate tumorigenesis and eventual metastasis through production of oncogenic signals and promotion of angiogenesis [19].
While reading this, you may notice that we have veered onto tangential thinking. Our main discussion involves monocytes, fibroblasts, and macrophages in the context of wound healing following acute inflammation. How, then, does chronic inflammation and malignant disease progression relate to this? The answer lies within the interactions between the cell types involved in these processes. The “forward talk” and “back talk” in each of these situations is critical for the progression of cell migration, development, signaling, and proliferation. Just as communication is vital for a healthy relationship between humans, so too is it vital for these cellular processes—even if pathological!
To realign our thinking regarding fibroblasts, it is purported that even in the absence of external stimuli, fibroblasts are capable of promoting monocyte migration through the production of similar protein signals to cytokines, called chemokines [17]. Further, this behavior is not limited to one cell type, but instead is an intrinsic property of fibroblasts [17]. This alludes to the concept of immunologically-activated myofibroblast “back talk” inducing monocytic migration, which then ties into our understanding of downstream fates of monocytes into classically or alternatively activated macrophages, for example.
With this in mind, lets tie a few more strings together. At a site of wound injury, circulating blood monocytes are recruited to the site of injury via the process of inflammation [21]. Through a multitude of cytokine signals between monocytes, tissue macrophages, and stromal cells, monocytes quickly acquire certain macrophage phenotypic characteristics once at the wound site [21]. The coordination between blood-derived and tissue macrophages allows for the synthesis and release of many different types of regulatory cytokines and chemokines that are crucial for the wound healing process [21]. This “forward talk” from monocytes and macrophages allows for stromal fibroblasts to acquire a myofibroblast phenotype in many cases, and facilitates processes such as matrix deposition, tissue contraction, and cellular reorganization. The last point of discussion for the purpose of this chapter will thus be how the “forward talk” and “back talk” demonstrate an elegant interplay, influencing the quality and quantity of wound repair.
Up to this point, we have discussed the key players of the inflammatory cascade, some cell types involved in wound repair, and the significance of the “forward talk” and “back talk” between some of these cellular driving forces. What implications, then, does all of this have with regards to our understanding of macrophages?
The answer to this question, as is the case with many scientific inquiries, lies in how we observe and assess the communicatory phenomena surrounding monocytes and macrophages. We’ve already alluded to how each cell type can innately behave one way when assessed in mono-culture, and how this behavior can be altered when assessed in co-culture. However, the extent to which we can improve our experimentation on these cell types is dependent on how accurately we can recapitulate some of the physiological processes that occur
Two potential ways through which the scientific community can better understand the complex interplay of monocytes, macrophages, and fibroblasts is through the use of co-culture systems, but also through the use of 3D cell culture systems. Such 3D systems could more intimately mimic the biological interactions that occur in living tissues and can provide novel perspectives beyond those attainable through 2D cell cultures [16, 22]. Current cell culture models that lack 3D and co-culture techniques are likely to underestimate potential immunomodulatory effects of stromal fibroblasts on monocytes and macrophage development due to the omission of complex bi-directional signaling that can occur between these cell types in living tissue [22].
For example, a novel macrophage and fibroblast co-culture model was designed and employed to assess the effect of material surface properties on inflammatory response regulation
A similar model designed by many of the same authors was also used to assess physiological host responses of biomaterials
A step in the right direction toward a more comprehensive experimental system for monocytes, macrophages, and fibroblasts is the recent development of organ-on-a-chip (OOC) models. These models employ microfluidic
Our understanding of macrophages has immensely improved over the past 140 years. So too has our understanding of myriad cellular interactions, such as inflammation, wound healing, and tissue homeostasis. This has, in part, been made possible by our simultaneous understanding of other crucial cell types, such as monocytes and stromal fibroblasts, and the role these cells have in our greater understanding of macrophages.
The importance of experimental models that employ both 3D and co-culture techniques for assessing cellular responses to inflammatory cytokine stimuli thus cannot be understated. To that end, we must appreciate the potential to accumulate incomplete or perhaps even fallacious data from mono-culture or 2D systems that do not incorporate various physiological factors that are at play during the “forward talk” and “back talk” of these cellular processes.
Looking ahead, our understanding of macrophages can and should be expanded upon. By designing cell culture systems that better enable assessment of the many cell-cell communications during inflammation, wound healing, and tissue homeostasis, we can continue to explore these incredible feats of nature. Advancements in these areas could improve clinical outcomes for patients suffering from numerous pathologies discussed in this chapter, such as chronic inflammation, tissue fibrosis, and even cancer formation. I look forward to the “forward talk” that we have yet to discover.
The authors declare no conflict of interest.
I would like to personally thank my undergraduate research thesis advisors, Dr. Cindy Hutnik and Dr. David O’Gorman, for their role in shaping my fascination for this area of scientific discovery. You both challenged me to learn and explore topics surrounding wound healing, inflammation, and fibrosis and enabled me to branch into fields of research that I had never thought to consider prior.
I would also like to personally thank Jelena Vrdoljak, the Author Service Manager for IntechOpen, for her role in supporting the production of this chapter. Her patience, guidance, and communication made submission to this book seamless and organized.
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Morrell",authors:[{id:"29913",title:"Prof.",name:"Jane M.",middleName:null,surname:"Morrell",slug:"jane-m.-morrell",fullName:"Jane M. Morrell"}]},{id:"68173",doi:"10.5772/intechopen.86799",title:"A Review on the Influence of Climate Change on Sheep Reproduction",slug:"a-review-on-the-influence-of-climate-change-on-sheep-reproduction",totalDownloads:1255,totalCrossrefCites:10,totalDimensionsCites:13,abstract:"Increasing food and natural fibre production ensure food security for nearly 10 billion people, the projected global population in 2050, without causing further environmental damage can be achieved by transforming systems and adopting sustainable agriculture practices within a changing climate. Globally, climate change effects are having both direct and indirect effects on agricultural productivity including changing rainfall patterns, drought, flooding and the geographical redistribution of pests and diseases. Climate change induced heat stress is thus one of the complex factors making sheep management and husbandry challenging in many geographical locations in the world. Within the sheep industry, reproductive wastage (RW) is a major challenge throughout the varying breeding landscapes. Reproductive wastage is defined as the early losses of embryos undergoing natural and/or artificial breeding programs. Our previous research showed that heat stress (THI > 75) and elevated glucocorticoid levels (indexed using faecal glucocorticoid metabolites) are linked to embryo loss in Merino ewes. This mini review discusses how extreme variation in climate such as heat stress affects the maternal reproductive performance in the Merino sheep and the impacts on the wool industry. 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The normal duration of estrus cycle is 21 days in cow, sow, and mare, 17 days in ewe, and 20 days in doe. The species which exhibit a single estrus cycle are known as monstrous and species which come into estrus twice or more are termed polyestrous animals. Among them some species have estrus cycles in a particular season and defined as seasonal polyestrous. It includes goats, sheep, and horses. On the other hand, cattle undergo estrus throughout the year. The estrus inducers can grossly be divided into two parts, that is, non-hormonal and hormonal. Non-hormonal treatments include plant-derived heat inducers, mineral supplementation, uterine and ovarian massage, and use of Lugol’s iodine. The hormones that are used in estrus induction are estrogen, progesterone, GnRH, prostaglandin, insulin, and anti-prolactin-based treatment. Synchronization can shorten the breeding period to less than 5 days, instead of females being bred over a 21-day period, depending on the treatment regimen. The combination of GnRH with the prostaglandin F2α (PGF2α)- and progesterone-based synchronization program has shown a novel direction in the estrus synchronization of cattle with the follicular development manipulation.",book:{id:"8545",slug:"animal-reproduction-in-veterinary-medicine",title:"Animal Reproduction in Veterinary Medicine",fullTitle:"Animal Reproduction in Veterinary Medicine"},signatures:"Prasanna Pal and Mohammad Rayees Dar",authors:[{id:"299126",title:"Dr.",name:"Mohammad Rayees",middleName:null,surname:"Dar",slug:"mohammad-rayees-dar",fullName:"Mohammad Rayees Dar"},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal"}]},{id:"16102",title:"Sperm Preparation Techniques for Artificial Insemination - Comparison of Sperm Washing, Swim Up, and Density Gradient Centrifugation Methods",slug:"sperm-preparation-techniques-for-artificial-insemination-comparison-of-sperm-washing-swim-up-and-den",totalDownloads:30025,totalCrossrefCites:8,totalDimensionsCites:8,abstract:null,book:{id:"185",slug:"artificial-insemination-in-farm-animals",title:"Artificial Insemination in Farm Animals",fullTitle:"Artificial Insemination in Farm Animals"},signatures:"Ilaria Natali",authors:[{id:"27026",title:"Dr.",name:"Ilaria",middleName:null,surname:"Natali",slug:"ilaria-natali",fullName:"Ilaria Natali"}]},{id:"71105",title:"Understanding Sow Sexual Behavior and the Application of the Boar Pheromone to Stimulate Sow Reproduction",slug:"understanding-sow-sexual-behavior-and-the-application-of-the-boar-pheromone-to-stimulate-sow-reprodu",totalDownloads:1168,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"In this chapter, we review the sexual behavior of domestic pigs, and the visible or measurable anatomical features of the pig that will contribute to detecting sows in estrus. 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Many factors can influence the development of mastitis; however, inflammation of the mammary gland is usually a consequence of adhesion, invasion, and colonization of the mammary gland by one or more mastitis pathogens such as Staphylococcus aureus, Streptococcus uberis, and Escherichia coli.",book:{id:"8545",slug:"animal-reproduction-in-veterinary-medicine",title:"Animal Reproduction in Veterinary Medicine",fullTitle:"Animal Reproduction in Veterinary Medicine"},signatures:"Oudessa Kerro Dego",authors:[{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego"}]}],onlineFirstChaptersFilter:{topicId:"1379",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:16,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. 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His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. 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