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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"7722",leadTitle:null,fullTitle:"Recent Advancements in the Metallurgical Engineering and Electrodeposition",title:"Recent Advancements in the Metallurgical Engineering and Electrodeposition",subtitle:null,reviewType:"peer-reviewed",abstract:"Metallurgy is a field of material science and engineering that studies the chemical and physical behavior of metallic elements, intermetallic compounds, and their mixtures, which are called alloys. These metals are widely used in this kind of engineering because they have unique combinations of mechanical properties (strength, toughness, and ductility) as well as special physical characteristics (thermal and electrical conductivity), which cannot be achieved with other materials. In addition to thousands of traditional alloys, many exciting new materials are under development for modern engineering applications. Metallurgical engineering is an area concerned extracting minerals from raw materials and developing, producing, and using mineral materials. It is based on the principles of science and engineering, and can be divided into mining processes, which are concerned with the extraction of metals from their ores to make refined alloys, and physical metallurgy, which includes the fabrication, alloying, heat treatment, joining and welding, corrosion protection, and different testing methods of metals. Conventional metal forming/shaping techniques include casting and forging, which remains an important processing route. Electrodeposition is one of the most used methods for metal and metallic alloy film preparation in many technological processes. Alloy metal coatings offer a wider range of properties than those obtained by a single metal film and can be applied to improve the properties of the substrate/coating system. This book covers a wide range of topics related to recent advancements in metallurgical engineering and electrodeposition such as metallurgy forming, structure, microstructure properties, testing and characterizations, and electrodeposition techniques. It also highlights the progress of metallurgical engineering, the ferrous and non-ferrous materials industries, and the electrodeposition of nanomaterials and composites.",isbn:"978-1-78984-687-4",printIsbn:"978-1-78984-686-7",pdfIsbn:"978-1-78985-908-9",doi:"10.5772/intechopen.77535",price:119,priceEur:129,priceUsd:155,slug:"recent-advancements-in-the-metallurgical-engineering-and-electrodeposition",numberOfPages:202,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"0d7ff67bd6f4c13830658bc6f9a75851",bookSignature:"Uday Basheer Al-Naib, Dhanasekaran Vikraman and K. Karuppasamy",publishedDate:"April 8th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/7722.jpg",numberOfDownloads:9101,numberOfWosCitations:0,numberOfCrossrefCitations:14,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:26,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:40,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 8th 2018",dateEndSecondStepPublish:"January 17th 2019",dateEndThirdStepPublish:"March 18th 2019",dateEndFourthStepPublish:"May 23rd 2019",dateEndFifthStepPublish:"June 22nd 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"182041",title:null,name:"Uday",middleName:"M.",surname:"Basheer",slug:"uday-basheer",fullName:"Uday Basheer",profilePictureURL:"https://mts.intechopen.com/storage/users/182041/images/system/182041.jpeg",biography:"Dr. Uday M. Basheer Al-Naib is a Senior Lecturer at Universiti Teknologi Malaysia (UTM). He completed his post-doctorate in Material Engineering at Universiti SainsMalaysia (USM) between 2013 and 2014. He received his Ph.D. in Materials Engineering from USM in 2013. He obtained his Master and Bachelor degree in Chemical Engineering from the University of Baghdad and the University of Technology, IRAQ, respectively. He has over 30 years of academic and practical experience in the field of ceramic and metal composites; metal alloys; advanced ceramics; porous ceramics; ceramic-metal joining; materials characterizations and forming; ceramic insulators; ceramic membranes; thermoelectric energy conversion and ceramic coating. He is acknowledged at the practical level for solving specific problems related to material industries. This was evident through his research work issued with different publishers and international material engineering journals with high impact factors. In addition to his own research, Dr. Uday has been acting as a supervisor of several academic theses (Masters and Doctorate) related to different fields of material engineering. He also has professional membership (ProfGradIMMM) in the Institute of Materials, Minerals, and Mining (IOM3) and Fellow membership (F.I.M.M.) at the Institute of Materials, Malaysia (IMM).",institutionString:"University of Technology Malaysia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Technology Malaysia",institutionURL:null,country:{name:"Malaysia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"199404",title:"Prof.",name:"Dhanasekaran",middleName:null,surname:"Vikraman",slug:"dhanasekaran-vikraman",fullName:"Dhanasekaran Vikraman",profilePictureURL:"https://mts.intechopen.com/storage/users/199404/images/system/199404.png",biography:"Dr. Dhanasekaran Vikraman is an assistant professor in the Division of Electronics and Electrical Engineering, Dongguk University, Seoul, Korea. He received his bachelor’s degree from Mannai Rajagopalaswamy Government Arts College, Mannargudi, affiliated with Bharathidasan University, India. He completed his master’s degree and Ph.D. at the Department of Physics, Alagappa University, India. Later, he received a visiting scientist position at KIST, Korea; a Marie-Curie Experienced Researcher fellowship at the Department of Physics, Aristotle University of Thessaloniki, Greece; and post-doc positions at Sejong University and Ajou University, Korea. He has authored more than 180 international journal articles and 3 book chapters and edited several books. He serves as a guest editor and topic editor for various journals.",institutionString:"Dongguk University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Dongguk University",institutionURL:null,country:{name:"Korea, South"}}},coeditorTwo:{id:"300938",title:"Dr.",name:"K.",middleName:null,surname:"Karuppasamy",slug:"k.-karuppasamy",fullName:"K. Karuppasamy",profilePictureURL:"https://mts.intechopen.com/storage/users/300938/images/system/300938.jpeg",biography:"Dr. K. Karuppasamy is currently working as an Assistant professor at Division of Electronics & Electrical Engineering, Dongguk University-Seoul, South Korea. He received his Ph.D. in the field of nanocomposite electrolytes for lithium-ion batteries in Anna University, Chennai, India in 2014. Later, he completed his Post-Doc positions at Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology Bombay, India, and Department of Chemical Engineering, Sogang University, Seoul, South Korea. His research interests mainly focus on synthesis and characterization of nanostructured materials for energy storage and conversion device applications. He has published more than 50 research papers in well reputed international journals and also authored for 25 international and national conference papers.",institutionString:"Dongguk University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Dongguk University",institutionURL:null,country:{name:"Korea, South"}}},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"944",title:"Metallurgy",slug:"metals-and-nonmetals-metallurgy"}],chapters:[{id:"67276",title:"Introductory Chapter: A Brief Introduction to Engineering Materials and Metallurgy",doi:"10.5772/intechopen.86497",slug:"introductory-chapter-a-brief-introduction-to-engineering-materials-and-metallurgy",totalDownloads:1014,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Uday M. Basheer Al-Naib",downloadPdfUrl:"/chapter/pdf-download/67276",previewPdfUrl:"/chapter/pdf-preview/67276",authors:[{id:"182041",title:null,name:"Uday",surname:"Basheer",slug:"uday-basheer",fullName:"Uday Basheer"}],corrections:null},{id:"67513",title:"Structure, Microstructure, and Some Selected Mechanical Properties of Ti-Ni Alloys",doi:"10.5772/intechopen.86717",slug:"structure-microstructure-and-some-selected-mechanical-properties-of-ti-ni-alloys",totalDownloads:1040,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:1,abstract:"Titanium nickel (Ti-Ni) alloys with low nickel (Ni) content can be used as biomaterials because they improve the mechanical properties, corrosion, and wear resistance of commercially pure titanium (Cp-Ti). Among the mechanical properties of a biomaterial, elastic modulus and microhardness are very important, and each varies according to the microstructure and interstitial elements such as oxygen and nitrogen as well as the amount of substitutional element and thermomechanical processing. Heat treatments are used to obtain a homogeneous microstructure, free of internal stresses structural, microstructural, also to retain or change the size of the phases. In this chapter, the preparation, chemical, structural, and microstructural, and mechanical characterization of Ti-Ni alloys are presented. The structural and microstructural characterization showed the predominant presence of α and Ti2Ni phases. There is no clear variation of the microhardness due to the amount of nickel. The dynamic elastic modulus was slightly above the Cp-Ti due to the addition of a new intermetallic phase (Ti2Ni) but did not vary significantly with the amount of Ni.",signatures:"Daniela Cascadan and Carlos Roberto Grandini",downloadPdfUrl:"/chapter/pdf-download/67513",previewPdfUrl:"/chapter/pdf-preview/67513",authors:[{id:"42880",title:"Prof.",name:"Carlos Roberto",surname:"Grandini",slug:"carlos-roberto-grandini",fullName:"Carlos Roberto Grandini"},{id:"292035",title:"Dr.",name:"Daniela",surname:"Cascadan",slug:"daniela-cascadan",fullName:"Daniela Cascadan"}],corrections:null},{id:"67075",title:"Cu-Based Shape Memory Alloys: Modified Structures and Their Related Properties",doi:"10.5772/intechopen.86193",slug:"cu-based-shape-memory-alloys-modified-structures-and-their-related-properties",totalDownloads:1818,totalCrossrefCites:8,totalDimensionsCites:14,hasAltmetrics:1,abstract:"Cu-Al-Ni shape memory alloys (SMAs) have been developed for high-temperature applications due to their ability to return to pre-deformed shape after heating above the transformation temperature, as well as these alloys have a small hysteresis and high transformation temperature comparing with other shape memory alloys. Adding some of the alloying elements such as Ti, Mn, Be, Zr and B or changing the interior content either Al or Ni by increasing/decreasing may have a significant effect on the phase transitions and enhance the mechanical properties of these alloys. However, the martensite phase transformation is the most important factor, which can be changing the whole properties of Cu-Al-Ni SMAs, where this phase is mainly affected by the alloying elements additions. This chapter reviews the effect of alloying elements on the phase transitions and the enhancement of the mechanical properties of this alloy.",signatures:"Safaa Najah Saud Al-Humairi",downloadPdfUrl:"/chapter/pdf-download/67075",previewPdfUrl:"/chapter/pdf-preview/67075",authors:[{id:"285879",title:"Dr.",name:"Safaa Najah Saud",surname:"Al-Humairi",slug:"safaa-najah-saud-al-humairi",fullName:"Safaa Najah Saud Al-Humairi"}],corrections:null},{id:"69959",title:"Fabrication of Dielectric Thick Films by Electrophoretic Deposition and Their Characterization",doi:"10.5772/intechopen.89996",slug:"fabrication-of-dielectric-thick-films-by-electrophoretic-deposition-and-their-characterization",totalDownloads:434,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this chapter, we have discussed about the fabrication of MgTiO3 and (K0.5Na0.5)(Nb0.7Ta0.3)O3 (KNNT) thick films via EPD, including the preparation of stable suspension, which is the essential requirement for EPD. Acetone and isopropyl alcohol are used as solvents for MgTiO3 and (K0.5Na0.5)(Nb0.7Ta0.3)O3, respectively. In both the cases triethanolamine (TEA) is used as the surfactant. It was observed that with increase in applied voltage and deposition time, the deposition of particle on the substrate has increased. For KNNT particle the optimum voltage and time to get quality film was 100 V and 10 min respectively. The surface morphology and film thickness was analyzed from SEM images. The thickness of KNNT and MgTiO3 films was found to be ̴32 and 18–20 μm (for film sintered at 900°C) respectively. In the case of MgTiO3 thick films, the sintering temperature plays an important role in the quality of films since it affects the density and grain growth. An increase in the sintering temperature, from 800–900°C, resulted in increase in the dielectric constant and reduced loss. The dielectric values of the KNNT and MgTiO3 thick film at 1 MHz was 320 and 18.3 respectively.",signatures:"Vineetha P and Venkata Saravanan K",downloadPdfUrl:"/chapter/pdf-download/69959",previewPdfUrl:"/chapter/pdf-preview/69959",authors:[{id:"308241",title:"Dr.",name:"Venkata Saravanan",surname:"K",slug:"venkata-saravanan-k",fullName:"Venkata Saravanan K"},{id:"308242",title:"Ms.",name:"Vineetha",surname:"P",slug:"vineetha-p",fullName:"Vineetha P"}],corrections:null},{id:"69535",title:"Effect of Electrolytic Compositions in Kinetics Mechanism of High-Purity Titanium Electrochemical Extraction Process",doi:"10.5772/intechopen.89528",slug:"effect-of-electrolytic-compositions-in-kinetics-mechanism-of-high-purity-titanium-electrochemical-ex",totalDownloads:777,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"High pure titanium, which is a critical material used for integrated circuit (IC) manufacturing, can be extracted by molten salt-electrolysis process. It will be widely used in the future for the process, is simple and easy, to achieve continuous production. However, some scientific questions need to be clarified at present. (1) Current efficiency needs to be enhanced by way of electrolyte designing and selection; (2) Product quality needs to be improved by means of electrolyte purification; (3) Electrolytic parameters need to be optimized for obtaining a better morphology. Above on, this chapter aims to explore the behaviors of titanium ions in various molten salts by means of chemical analysis and electrochemical testing. The complexes will be discussed for clarifying the influence of electrolytic compositions on kinetics mechanisms of the electrolysis process and the properties of the molten salt. A quantitative method for estimating oxygen content will be also discussed for the purpose of optimizing the composition of electrolytes. The chapter will provide a better understanding mechanism of kinetics of high pure titanium electrolysis, and the basic theory and experimental data can be used for reference in the industrialization process.",signatures:"Jianxun Song, Yusi Che, Yongchun Shu and Jilin He",downloadPdfUrl:"/chapter/pdf-download/69535",previewPdfUrl:"/chapter/pdf-preview/69535",authors:[{id:"307630",title:"Associate Prof.",name:"Jianxun",surname:"Song",slug:"jianxun-song",fullName:"Jianxun Song"},{id:"310156",title:"Dr.",name:"Yusi",surname:"Che",slug:"yusi-che",fullName:"Yusi Che"},{id:"310188",title:"Prof.",name:"Yongchun",surname:"Shu",slug:"yongchun-shu",fullName:"Yongchun Shu"},{id:"310189",title:"Prof.",name:"Jilin",surname:"He",slug:"jilin-he",fullName:"Jilin He"}],corrections:null},{id:"63366",title:"Ionothermal Synthesis of Metal-Organic Framework",doi:"10.5772/intechopen.79156",slug:"ionothermal-synthesis-of-metal-organic-framework",totalDownloads:1e3,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Ionothermal synthesis employs ionic liquids for synthesis of metal organic frameworks (MOFs) as solvent and template. The cations and anions of ionic liquids may be finely adjusted to produce a great variety of reaction environments and thus frameworks. Organisation of the structures synthesised from related ionic liquid combinations give rise to provocative chemical trends that may be used to predict future outcomes. Further analysis of their structures is possible by reducing the complex framework to its underlying topology, which by itself brings more precision to prediction. Through reduction, many seemingly different, but related classes of structures may be merged into larger groups and provide better understanding of the nanoscopic structures and synthesis conditions that gave rise to them. Ionothermal synthesis has promised to enable us to effectively plan the synthesis ahead for a given purpose. However, for its promise to be kept, several difficult limitations must be overcome, including the inseparable cations from the solvent that reside in the framework pore.",signatures:"Hyun-Chang Oh, Sukwoo Jung, Il-Ju Ko and Eun-Young Choi",downloadPdfUrl:"/chapter/pdf-download/63366",previewPdfUrl:"/chapter/pdf-preview/63366",authors:[{id:"246574",title:"Dr.",name:"Eun-Young",surname:"Choi",slug:"eun-young-choi",fullName:"Eun-Young Choi"},{id:"247406",title:"Mr.",name:"Hyun-Chang",surname:"Oh",slug:"hyun-chang-oh",fullName:"Hyun-Chang Oh"},{id:"258419",title:"Mr.",name:"Il-Ju",surname:"Ko",slug:"il-ju-ko",fullName:"Il-Ju Ko"},{id:"258420",title:"Mr.",name:"Sukwoo",surname:"Jung",slug:"sukwoo-jung",fullName:"Sukwoo Jung"}],corrections:null},{id:"71302",title:"Characterization and Treatment of Real Wastewater from an Electroplating Company by Raw Chitin",doi:"10.5772/intechopen.89058",slug:"characterization-and-treatment-of-real-wastewater-from-an-electroplating-company-by-raw-chitin",totalDownloads:555,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The objective of this chapter is to study of the heavy metal removal in real waste water. The use of the raw chitin shows itself of big potential for the treatment of the liquid discharges of the studied unity. It showed itself capable to treating heavy metal loads superior to 200 mg/l by presenting percentage removal between 90 and 97%, as in the case of Cu2+. After the study performed on the global discharge, we were interested in the local treatment that rinses out plating baths, and this is the aim to optimize the treatment process and develop a project of treatment plant, recycling in situ based on the adsorption technique on raw chitin. Examination of the results allowed us to save significant percentages of sewage treated for metals mainly copper. Raw chitin showed a high affinity toward heavy metals in rinsing water supply. According to this study, the design of a treatment facility of this type of release must include a waste water treatment by adsorption on chitin. The valuation of the raw chitin is situated in this context as an economically adsorbing material, which can be an interest at the level of the recovery of heavy metals in waste water.",signatures:"Boukhlifi Fatima",downloadPdfUrl:"/chapter/pdf-download/71302",previewPdfUrl:"/chapter/pdf-preview/71302",authors:[{id:"230141",title:"Prof.",name:"Boukhlifi",surname:"Fatima",slug:"boukhlifi-fatima",fullName:"Boukhlifi Fatima"}],corrections:null},{id:"66917",title:"Analysis of Mechanical Properties of Austempered Ductile Iron Weld Joints Using Developed Electrode",doi:"10.5772/intechopen.84763",slug:"analysis-of-mechanical-properties-of-austempered-ductile-iron-weld-joints-using-developed-electrode",totalDownloads:844,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"In the present investigation mechanical properties of austempered ductile iron (ADI) joints have been studied using two developed electrodes containing with and without Ce content and co-related between microstructure and mechanical properties. Austenitization was done at 900°C for 2 h and austempering at 300 and 350°C for 1.5, 2 and 2.5 h holding time. At 300°C microstructure shows needle shaped bainitic ferrite with lower amount of retained austenite indicate higher hardness and lower impact toughness. However, at 350°C shows feathery shaped bainitic ferrite with higher amount of retained austenite to demonstrate lower hardness and higher impact value. Both the welded joints at both austempering conditions tensile samples broke from the base metal indicates 100% joint efficiency. Fatigue life was varied with varying the austempering temperature and shows higher fatigue life at 350°C austempering temperature presence of higher amount of retained austenite and finer the bainitic ferrite size with smaller graphite nodules. Ce in weld metals to refine the microstructure and shows higher impact toughness and fatigue strength with lower hardness value at both austempering temperatures.",signatures:"Tapan Sarkar",downloadPdfUrl:"/chapter/pdf-download/66917",previewPdfUrl:"/chapter/pdf-preview/66917",authors:[{id:"290095",title:"Mr.",name:"Tapan",surname:"Sarkar",slug:"tapan-sarkar",fullName:"Tapan Sarkar"}],corrections:null},{id:"69501",title:"Spark Plasma Sintered High-Entropy Alloys: An Advanced Material for Aerospace Applications",doi:"10.5772/intechopen.86839",slug:"spark-plasma-sintered-high-entropy-alloys-an-advanced-material-for-aerospace-applications",totalDownloads:971,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"High-entropy alloys (HEAs) are materials of high property profiles with enhanced strength-to-weight ratios and high temperature-stress-fatigue capability as well as strong oxidation resistance strength. HEAs are multi-powder-based materials whose microstructural and mechanical properties rely strongly on stoichiometry combination of powders as well as the consolidation techniques. Spark plasma sintering (SPS) has a notable processing edge in processing HEAs due to its fast heating schedule at relatively lower temperature and short sintering time. Therefore, major challenges such as grain growth, porosity, and cracking normally encountered in conventional consolidation like casting are bypassed to produce HEAs with good densification. SPS parameters such as heating rate, temperature, pressure, and holding time can be utilized as design criteria in software like Minitab during design of experiment (DOE) to select a wide range of values at which the HEAs may be produced as well as to model the output data collected from mechanical characterization. In addition to this, the temperature-stress-fatigue response of developed HEAs can be analyzed using finite element analysis (FEA) to have an in-depth understanding of the detail of inter-atomic interactions that inform the inherent material properties.",signatures:"Ayodeji Ebenezer Afolabi, Abimbola Patricia I. Popoola and Olawale M. Popoola",downloadPdfUrl:"/chapter/pdf-download/69501",previewPdfUrl:"/chapter/pdf-preview/69501",authors:[{id:"214931",title:"Prof.",name:"Api",surname:"Popoola",slug:"api-popoola",fullName:"Api Popoola"},{id:"297964",title:"MSc.",name:"Afolabi",surname:"Ayodeji",slug:"afolabi-ayodeji",fullName:"Afolabi Ayodeji"}],corrections:null},{id:"69178",title:"Cutting Superhard Materials by Jet Methods (on Functional Approach)",doi:"10.5772/intechopen.87094",slug:"cutting-superhard-materials-by-jet-methods-on-functional-approach-",totalDownloads:648,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Dimensional processing of products made from hard alloys and superhard materials is of a certain interest for contemporary high-technology production, as it enables creation of half-finished or final products of various geometric shapes from workpieces obtained by sintering. In this case conventional methods, first of all abrasive processing and electroerosion cutting, find limited application, which is caused by special features of the structural condition and physical and mechanical properties of the materials of the processed workpieces. The functional approach can be used in working of composite workpieces from laminated superhard materials. The performed research with the use of hydro-abrasive cutting (HAC), laser cutting (LC), laser cutting with water cooling (LCC), and water jet-guided laser (WJGL) has enabled studying of the intensity of destruction area introduction into the worked piece and finding out the functional features of a particular process that are caused by the working conditions. It has been shown that the hypothesis of quasistationary rate of destruction is unacceptable for such materials, which is caused by the structure and high hardness of the material. It has also been determined that when deepening increases, the rate of jet introduction has a pronounced tendency toward reduction.",signatures:"Alexandr Salenko, Viktor Shchetynin, Galina Gabuzian, Evgeny Lashko, Mohamed R.F. Budar, Sergey Klimenko and Alexandr Potapov",downloadPdfUrl:"/chapter/pdf-download/69178",previewPdfUrl:"/chapter/pdf-preview/69178",authors:[{id:"294449",title:"Dr.",name:"Oleksandr",surname:"Salenko",slug:"oleksandr-salenko",fullName:"Oleksandr Salenko"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6084",title:"Recent Advances in Porous Ceramics",subtitle:null,isOpenForSubmission:!1,hash:"c6749abbf887821d1030727f7eee1d6f",slug:"recent-advances-in-porous-ceramics",bookSignature:"Uday M. 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The discredit from which liberalism suffers in our time, in many countries, is an astonishing and appalling phenomenon. In reality, this discredit is based on caricatures of liberalism, complacently spread by those who have an interest in fighting it or who are unaware – sometimes voluntarily – of what is the true liberalism. Thus, it is claimed that liberalism is supporting rich people against poor people, that it gives human beings the sole objective of seeking material benefits, that it advocates selfishness, etc. Nothing could be further from the truth, and that is why all those who love the truth should be concerned about learning more about liberalism [1]. Unfortunately, all people have very rarely the opportunity to make this intellectual re-examination, and I am struck, for example, by the fact that all young people who discover by chance a correct explanation of what liberalism is are amazed by its intellectual coherence and the solidity of its ethical foundation.
Liberalism consists into developing ideas based on individual behavior and individual aims to analyze or to promote the working of a society. And this is why liberalism must be considered as a true humanism, since humanism means a way of thinking or acting coherently with what human beings are. And humanism can be considered as the foundation of ethics since ethical actions and thoughts imply to be respectful of the very nature of human beings.
Indeed, liberalism is both a method of analysis and an ethic. It is a method of analysis because it consists in thinking – and this should be obvious – that we can only understand the functioning of a society by having a realistic vision of what a human being is, of his deep nature, of his behavior. A society is not a kind of great machine, but a collection of men and women who have – each of them – their own individuality, but who interact one with the other and are therefore, from this point of view, necessarily in solidarity with each other. Just to give an illustration of the problem, economists quite often develop analyses of what is called “macroeconomics.” But they possibly define discretionary concepts – such as “national income” – which may not have any link with individual behaviors. Thus they may deduct economic proposals which are not respectful of individual behaviors and aims so that they may not be efficient and, above all, they may not be coherent with ethics. To avoid such errors, many intellectuals are in favor of what is called praxeology, that is, the science of human action. Such is the case, in particular, of Ludwig von Mises in his book,
As regards liberal ethics [5] it implies that there is a universal duty to be respectful of everyone’s legitimate rights. Of course, each of us also has his or her own personal moral principles regarding how to behave with others. These personal morals are highly respectable, provided, however, that they are not incompatible with the universal ethic of respect for the legitimate rights of others.
It may be said that liberal values are Christian values or at least are fully compatible with them. It is Christianity which has enabled the emergence of individual freedom in the Western world and which has, moreover, enabled economic take-off and enabled countless masses to escape from poverty. With Christianity, as with liberalism, a human being is not just a cog in the great social machine, but a person who deserves respect as such.
Liberalism and Christianity share a common basis in terms of universal values. But, of course, within this general framework each can develop its own moral concepts. Thus, Christianity considers altruism as a virtue. But this is not incompatible with liberalism. Indeed, a liberal must be intransigent with the universal duty to respect the rights of others, but he does not claim to suggest a particular conduct to human beings, for example, to suggest – or, even less, to impose – altruistic or selfish behavior toward this or that person or category of persons. He considers that this is a matter of personal responsibility and that it is his duty to respect such personal ethics as long as it does not contradict the universal duty to be respectful of the rights of others. That is why it is absurd to say that liberalism supports selfishness. Based on an absolute respect for individuals, liberalism refrains from making judgments about the conduct and opinions of individuals unless they infringe the legitimate rights of others. Thus, it will consider a person’s generous behavior to be perfectly respectable. But it will challenge the State’s claim to redistribute resources through the use of coercion, which in itself constitutes an infringement of the freedom and rights of individuals. Solidarity is worthy of respect when it is voluntary; it is not worthy of respect when it is compulsory. In the latter case, moreover, it is all the less not a moral value since in reality, it is most often used as a means for politicians to serve their own personal interests: They obtain votes in elections by distributing the resources they have taken by force from certain taxpayers. And this is all the more questionable since many people bear the burden of taxes without knowing it.
By giving to itself a virtual monopoly in the exercise of solidarity, the State destroys natural solidarity. It destroys the incentives to work, save, innovate, and undertake in order to create resources (since it takes a large part of the fruits of all efforts), which undermines the prosperity of all and harms the poorest in particular. At the same time, however, it destroys the propensity of individuals to act generously, as they are led to see this role as being played by the State.
This shows how wrong it is to claim that liberalism is attached to material values, that it defends the rich against the poor, the powerful against the oppressed. It is, on the contrary, state interventionism which, by depriving individuals of the full exercise of their freedom, provokes a war of all against all. As the famous French economist [6] put it so well at the beginning of the nineteenth century, “The State is the great fiction through which everyone tries to live at the expense of everyone else.” It should therefore come as no surprise if, in a country like France, one has the feeling that most citizens are embittered, demanding, and frustrated: their fate now depends only marginally on their own efforts and sense of responsibility, it depends on what the State will take from them and give to them in this war of all against all.
What a contrast with what would be a perfectly liberal society based on the freedom of each individual and therefore on individual responsibility! Such a society, totally respectful of the rights of each person, would be peaceful and prosperous. It would allow everyone to live according to his own moral principles, his own goals, and his own decisions. Could we not then trust human beings to build, through their interactions, the peaceful society that each of us deeply desires within our society? And should we not be surprised that citizens hand over so many decisions concerning their lives to men and women who are not chosen for their sense of ethics or, for that matter, for their skills, but more often than not for the promises they make and who are financed by the catching of resources which they did not create and which therefore do not belong to them? It should not be surprising, moreover, that in this immoral world built by statesmen, we find all sorts of corruption scandals and illicit enrichment throughout the world. These are obviously the same people who go to war against liberalism because it threatens their privileges and their spoliations. They do not hesitate to disguise reality and present liberalism as something it is not. In this terribly politicized world in which we find ourselves unfortunately, the confusion of ideas reaches an incredible level. One comes to reproach so-called liberal policies (which are not liberal) for the failures due to state interventionism. As Marine Le Pen – the head of a nationalist extreme-right political party in France – has said, one even comes to claim that liberalism is totalitarianism, even though it is and always has been the only real enemy of totalitarianism!
Should not the trust we place in human beings and in their extraordinary capacities lead us to hope that all these confusions, lies, and the resulting disasters will be dispelled and that, as free beings, they will be able to live in a harmonious and peaceful society?
However many people believe that there are so-called inequalities between the members of a society (for instance the members of a country) and that it is the important role of a State to decide a redistribution policy. It is understandable that some people find it difficult to accept large differences in incomes and living conditions, and the fight against inequality therefore seems sympathetic. But beyond feelings, what is called “inequalities” must be rigorously analyzed. In a country, there is not one big central distributor who would have created all the wealth and who could distribute it in an egalitarian way. There is a multitude of individuals who create their wealth thanks to their efforts of work, savings, entrepreneurial risk-taking, etc. What characterizes a human society is not inequality, but diversity. All human beings are different and the wealth they create is unequal because they differ in age, talents, abilities to make efforts, life choices, etc. However, all members of a society are “united,” for example, because we cannot have prosperous employees if we discourage their employers by overloading them with exorbitant taxes.
At some point in time the situations of all individuals are obviously diverse (“unequal”). But these relative situations change and it is important to give everyone a chance. It is interesting to note, for example, that according to many studies in the United States a significant proportion of those who have high incomes at one point in time have much lower incomes a few years later. On the contrary, there is a significant progress for those with low incomes.
The feeling of solidarity exists in the hearts of human beings and there have always been private initiatives to take care of the weakest people. This voluntary solidarity has a moral basis: those who practice it sacrifice resources they have created to help others. This has nothing to do with the so-called compulsory “solidarity” practiced by representatives of the State and public organizations, which is done with the money of individuals (even if some have a sincere desire to help others). And one can always suspect that they are pursuing personal goals: getting votes in elections. This is why, for example, in most countries, an income tax has progressive rates: politicians do not lose much electoral support by taxing a small number of high-income people heavily in the name of fighting inequality. But in fact they are hurting everyone. Indeed, in a free society, those with high incomes are the ones who create the most wealth through their talent, their productive efforts, and their ability to take risks. They create jobs, and they introduce technical progress which increases everyone’s purchasing power. But if they are too much taxed, they are discouraged from making efforts or they go into exile, depriving their country of opportunities for growth, which is detrimental to everyone. And it would be better if, by reducing this policy of fighting inequality, one could finally see a strong growth, a rapid increase in wages and full employment. The important thing is that everyone should be able to become richer, especially the poorest people, whatever is the evolution of “inequalities.”
Many people – and specially politicians – claim to be in favor of “social justice.” But it is important to analyze what is meant by “social justice” and the remarks made above can help to develop such an analysis. There are two very different definitions of “social justice.” The first one is concerned by what could be called “universal ethics,” namely being respectful of individual rights. On the other hand, the specific and personal ethics of each individual is inspiring the second definition of “social justice”: it consists in comparing the actual situation of individuals and to decide subjectively that some specific differences are fair or not. This second definition is the most widely accepted one and usually, when speaking of “social justice” people care mainly about the monetary incomes of individuals. According to a personal judgment – more or less shared by a great number of people – one considers that the differences between individual incomes must be more or less diminished. Now, some more characteristics of both definitions must be clarified in order to have a rigorous analysis of this problem.
Let us first consider the first definition of social justice. We just mentioned that it means that individual rights are respected by everyone. But it is not sufficient to care about respecting rights, since individual rights have to be ethically founded for a situation respectful of rights to be ethically justified. In fact, let us assume that there is a society in which most properties have been got by stealing them; it is obvious that, in such a case, there is no justification for respecting property rights! This means that it is important to determine in which cases property rights are legitimate.
The basic principle of ethics consists in claiming that individuals are free, which means that they are not subject to the constraint of other people, that is, they are the owners of themselves. But one is not his own owner if ever he is not the owner of the goods and services he is creating by using his mind and his physical activities. Therefore, it must be considered that legitimate property rights are those which are obtained by acts of creation (and obviously, by exchanging goods and services which have been created by partners in exchange).
Thus, the first definition of social justice can potentially be accepted by everyone all over the world (at least if people agree about the legitimacy of property rights). But, as regards the second definition of social justice – namely a comparison of the standard of life of individuals in a society – each individual has a different definition of what he considers as socially fair. There is therefore a very important problem, namely the coherence between these different opinions. As, very likely, all individuals have different opinions about “solidarity” there cannot be an “universal” criterion of what should be considered as “social justice,” that is, the fair distribution of resources. It is then assumed that social justice in the distribution of incomes can be defined by a majority of votes in a democratic system. Nowadays, when speaking of social justice one implicitly means redistributive activities (social policy), which refers to the second meaning of social justice. It is implicitly assumed that social justice implies a reduction of inequalities. In the term “equality” or “inequality,” there is an implicit value judgment. This is why one considers the reduction of inequality as being a morally justified policy.
Libertarians are frequently critical of egalitarian policies so that it is often claimed that they promote selfishness, and that liberalism must be challenged for ethical reasons. But human beings are characterized by their diversity and this is why one should, on the one hand, talk about diversity rather than inequality and, on the other hand, be respectful of this diversity inherent to human nature. The term of inequality would be justified if the fate of all individuals – and in particular their standard of living – was determined by a central authority owning all resources and able to “distribute” them more or less “equally.” But it is not the case – fortunately – in a free society and that is why the expression “income redistribution” is totally misleading.
However, contrary to what is often claimed, liberalism is not supporting the freedom of anyone to do anything, but the freedom to act while respecting the legitimate rights of others. This freedom to act implies the freedom to implement one’s own personal ethics, but only if it is legitimate and if it is respectful of universal ethics. It is the case if someone who holds legitimate property rights on certain resources uses a portion of these resources to help another person; his acts are then in accordance with his personal morality without being damaging to universal morality. This behavior is totally moral and respectable. But someone who steals goods to a person to give his loot to another person – because his personal morality induces him to help the latter – violates the property rights of the first person and therefore universal morality.
Now, it is exactly the same with “inequalities policies”: Statesmen (politicians and bureaucrats) levy, thanks to coercion, resources from some people (known as citizens) to give them to others. In doing so, they undermine universal morality and therefore we must accept the idea that a policy aiming at the reduction of “inequalities” is immoral in principle. Although statesmen are using their monopoly of legal constraint so that this coercion is legal, it is however immoral since it is an attack on legitimate property rights (and this is why one must consider as a moral duty to cut taxes as much as possible). It may be that, in doing thus, some statesmen try to implement their own personal morality, but anyhow they infringe universal morality. On the other hand, it is well known that, so doing, they often pursue personal goals. Thus, to be elected or re-elected, they transfer resources to a large number of voters at the expense of a minority. As we already said, it is for this reason that the progressive tax – immoral and unequal by nature – does exist. And the fact that politicians are elected by a majority of voters do not give them legitimacy since one can always find a majority to violate the legitimate rights of a minority as far as the exercise of legal constraint is possible.
Furthermore, equality is defined arbitrarily from a single criterion, namely income at some point of time. However the objectives of individuals are varied (they do not concern only monetary income), their age is different and therefore their experience and their capital (which are the sources of their incomes). Let us imagine that all individuals be identical, there would, however, be an inequality in incomes according to the age of each person.
Of course, some are victims of physical or mental disabilities and human history shows that charity has always existed in such cases. This charity, decided personally by each individual, is extremely respectable, unlike so-called public charity (which, moreover, is vitiated by prospects concerning elections and which therefore leads to new inequalities between those who thus come to power – claiming to take in charge poverty – and those who must undergo public choices).
Frédéric Bastiat has been a member of the French Parliament and he sat on the benches of the left. Left members of the Parliament applauded him when he advocated economic freedom to improve the life standard of the poorest people. Is that inconceivable in the present period? Improving the life standard of everyone, especially the most vulnerable, is possible and desirable. But we must take the means to do so. Liberalism is the best mean.
Edison’s words are as relevant to today’s start-up scene as they were at the turn of the twentieth century when a flurry of electro-mechanical invention was the touchstone of innovation. In this sense, the innovator’s talent is therefore a combination of illuminating a problem or opportunity with insight and identifying an improvement with imagination. The improvement might be incremental or revolutionary. Edison embodied an approach that was built on systematic experimentation. Design Thinking holds the promise of reducing the time taken for this kind of deductive effort through creative collaboration. This chapter provides an overview of how Design Thinking has evolved and how the stages of convergence and divergence can be harnessed to enable non-designers ideate effectively.
Design Thinking (DT) has developed from its academic roots in the 1970s into a widely adopted business-critical capability today [1]. The value of DT continues to diffuse through ever-increasing numbers of innovation agencies and consultancies, aided by a number of do-it-yourself toolkits that have been devised by high-profile design organisations such as LUMA and IDEO. The popularity of DT, within many fields, has embedded the notion that design is a practical means to help drive innovation (at the level of new ideas and concepts) as a distinctive and human-centred approach that rivals traditional marketing-led and scientific/engineering strategies. The popularity of ‘design-led’ organisations, the visibility of high-profile advocates including Jonny Ives, a growing awareness in the media and prevalence of an agile, diverse, empowered and lean oriented workforce have all contributed to DTs notoriety.
DT is itself an innovation and one that ‘productises’ the problem-solving strategies creatives apply when envisioning new experiences, products and services in three ways. Firstly, through advocating a human-centred design methodology based on research and iterative solution development. Secondly, through a defined and distinctive (if not unique) mindset of creative thought cultivated in art and design schools. Lastly, it embodies a set of traditional applied practices and principles that span the diversity of design of new products and services from the archaic (drawing) to the modern (ethnography).
The notion that designers are ‘futurologists’ in speculating about what could be is a strong current in the literature, as is the idea that design is about realising how things ought to be as utopian endeavour. Buchanan [2] argues that DT can be used to tackle ‘wicked problems’ that defy deductive thinking or logical progression from problem to solution. Rittel and Webber [3] coined this phrase ‘wicked problems’ to describe the kind of intractable issues where ‘the problem is not understood until after the formulation of a solution’ [4] that are amenable to creative strategies.
Unpicking the kinds of pithy problems (e.g. climate change) typified by fuzzy or wicked problems and creating good solutions to them is, so the rationale for DT suggests, best done by reframing (via provisional concepts and iteration) rather than applying sequential problem-solving techniques. Lawson cites Schön’s [5] use of such cognitive (re)framing where problem definition and solutioning are in a continual dialogical loop only resolved when problem and solution are harmonised into a viable future state. This influential construct (reframing) underlies a popular visualisation of effective creative thinking (the double-diamond model [6]) where creative thinking progresses through phases of convergent and divergent thinking:
Convergent thinking – thinking is reductive, narrowing and solution oriented
Divergent thinking – thinking is generative, open-ended and outward
DT is the product of at least three distinct and related traditions that span design but also connect to proximal practices as diverse as anthropology, business consulting, open innovation, agile-style product development and lean manufacturing techniques. Service design is also an influence in positioning designers as creative facilitators of collaboration rather than as creative specialists. In the broadest sense, DT encompasses holistic set of principles, techniques and methods that cover all aspects of innovation, specifically through the lens of creativity and also importantly underpinned by a broad humanistic approach that spans the methodological realisation of those principles through bottom up integration of human needs within supporting research and concept development (Ethnography) to practical ways of empowering people to innovate themselves (Participatory Design).
DT’s overarching approach aligns to a Human-Centred Design (HCD) perspective, where innovation is focused on ensuring new products and services capitalise on human capabilities as well as their limitations. Optimal innovation with new technology augments and enhances human physical and cognitive abilities in order to achieve goals that would otherwise be difficult (or impossible) to achieve by humans or machines alone. In most cases, user involvement is focused on refining pre-defined solutions through incremental ‘tweaks’. This means that the scope of innovation is generally limited to shaping the way a solution is manifested as a marketable product or service (e.g. screens for a shopping cart flow) rather than the broader solution itself (e.g. online purchasing).
This strand in DT emerged from socio-technical design [7] in the 1970s and is explicitly aimed at addressing the introduction of new technology. Balancing human needs with the potential risks and benefits of technology was extended in Participatory Design (PD). The PD movement [8] originated in the Scandinavian and Nordic countries during the 1970s and was overtly political in promoting social democracy especially in designing interactive systems for the workplace. This focus was predicated on the realisation that new systems often failed because of conflicting interests among stakeholders and also that workers loss of control of their work had a detrimental effect of productivity and industrial relations. Lastly, Human-Computer Interaction (HCI) synthesised these two traditions into a multidisciplinary approach that unequivocally focuses on innovation through developing novel ways of interacting with technology and removing barriers to adoption through advocating usability. HCI research usually focuses on conducting primary research with representative users in order to understand their wants, needs and barriers to adoption, and using the resulting insights to ideate potential concepts that are then used to develop representations of the future solution through low-fidelity prototypes. These enable researchers to test and refine potential solutions before full development to make sure that they meet users’ needs and are likely to be adopted by broader audiences.
DT extends human-centricity beyond participation into a deeper level of innovating to meet latent human needs via ethnographic-based research. This extends the scope of innovation out, so that potential solutions emerge as insightful possibilities from the research activity itself rather than field work being used for validation. This ground-up approach increases the likelihood that solutions are grounded in human needs and in some cases meet latent needs that would otherwise be difficult to elicit let alone manifest through tangible product or service concepts.
Ethnography research methods are integral to this strand as is the work of Suchman [9]. She contends that activity is conditional on any given situation in which it takes place and that behaviour is therefore of an improvised rather than planned nature. Allied methods including ethnomethodology [10] have been developed which also lend themselves to understanding complex work situations such as air traffic control, where possibilities to innovate are highly constrained. A more pragmatic set of methods have integrated this approach under the banner.
Contextual Design [11] involves field research (usually in a workplace setting) but with less focus on the granularity of everyday life observed and with more a priori structuring of observational data through boundary type constructs such as personas and workflows that help innovators share knowledge and develop ideas around.
Cultural Probes [12] extends the approach and reduces the role of the research to gather data on people’s non-instrumental latent needs. This is done by proxy so that participants produce their own representation and prototypes using a kit or materials including cards, diaries and throwaway cameras that are given to them.
In conclusion, the various approaches to behaviour-centred innovation use field work not only to generate insights but also locate innovation within existing human practice rather than as a separate activity done by others.
The Design Methods movement [13] is the earliest (and perhaps the most accessible) contributing tradition to DT. Predating the digital revolution of the new economy, the Design Methods movement focuses on defining easy to use, reusable tools and techniques for innovation that can be used by designers and non-designers alike. First among these is Synectics which predates ‘designerly’ cycles of convergent and divergent thinking and is a clear precursor of ideation.
The Design Methods approach is underpinned by two principles. Firstly, that design can be distilled down into discrete techniques that anyone can apply to a given problem or opportunity. Secondly, that solutions are rarely uniquely novel and rather are invariably composed of common components, an approach that draws on the work of Christopher Alexander.
DT’s closest equivalent to synectics is ideation. Ideation is usually done in groups, on the rationale that cohort size correlates with quantity and quality of outputs. Idea generation is also most commonly positioned as the replicating creative cognitive processes employed by designers and is usually conducted as a structured activity that optimises the fuzzy challenge of developing novel ideas. Ideation teams usually consist of between 5 to 10 participants and facilitation aims to foster a ‘designerly’ working environment where the focus is on uncritically, producing many ideas. Similar techniques are found in engineering (e.g. TRIZ) [14].
Popular idea generation techniques include vernacular examples such as ‘round robin’ and ‘crazy 8 s’ as well as more solidly research-based techniques that often draw on the work of Edward de Bono [15]. de Bono published a number of works that introduced foundational terms and techniques such as ‘lateral thinking’ through best-selling books, such as ‘Serious Creativity’ (ibid). The various techniques described in these publications, not only have a natural affinity with DT, but are arguably the tangible foundations of this way of problem solving outside of the design methods school.
A number of studies have explored idea generation methods within the tightly defined context of early concept development. Past research by the authors into the effectiveness of random input [16] suggest that this method generated more numerous and of higher quality ideas than a control group who did not apply the method to an ideation challenge. The study was undertaken with a group of male and female graduates (n = 30). All participants were given a brief relating to a challenge to produce ‘ideas to improve the workplace’. The study involved randomly assigning subjects into four groups. Each group consisted of three to four ideators, who had recently graduated and were under the age of thirty. The cohort was then assigned to either morning or afternoon sessions (giving eight groups in total – ABCD x 2) who were given ideation challenges under differing conditions.
Stress was also found to affect idea creation. Participants who were less physiologically stimulated produced less and poorer quality ideas than those who were moderately excited, although too much stress is known to negatively impact creativity. It maybe that some controlled physical and mental stimulation might enhance group creativity within a certain threshold. These findings helped inform the authors during the development of the Ideation Grids method described in the following section. These evolve traditional Synectic principles and idea development techniques into an easy to use, structured and optimised ideation tool.
Ideation Grids are a design thinking method that applies crowd-sourcing to develop ideas and is focused on pushing ideators past their first and likely least innovative idea, to generate a wide variety of novel solutions. These are elicited through short challenge rounds using predefined challenge cards as stimuli. Ideation grids are based on seven elements comprising:
The authors have successfully applied Ideation Grids to many situations and problems. Preparation for sessions typically includes logistical activities, such as identifying suitable participants and a conducive environment. This can be a physical space or a digital whiteboard. The ideal group size is between five to ten people and sessions should be a maximum of two hours and ideally under an hour. Running a sequence of shorter sessions is more effective than trying to fit many rounds into one long one. Giving participants time to reflect on an ideation challenge can garner more and better ideas. Breaks used judiciously, can improve quality and quantity of ideas.
Participant numbers can be increased, but the authors have found that larger cohorts need to be split into smaller groups comprising of a maximum of ten participants each with their own moderator. This can be achieved through breakout rooms if conducting this exercise remotely. Participants’ profiles are important considerations too. Generally, a good mix of levels (junior to senior), background, experiences and roles (e.g. customer service to sales) works better than homogeneous groups. Over-representation of a single level or grouping tends to skew the ideas that are generated toward the dominant group’s perspective. If the majority is also senior, then this has the negative affect of also inhibiting others who are junior or extroverted. In some cases, it is better to split groups by level, group or when the topic to ideate requires extreme focus than a broader set of viewpoints.
Planning then moves to identifying the right ideation topic and refining what often begins as an ambiguous (or overly specific) starting point. Ideally topics have been developed collaboratively and are also the product of some level of domain research. Ideal ideation topics are one sentence phrases that communicate the problem or opportunity to develop ideas around. Getting them right is an art. Too wordy or long and they can slow down creative thinking and lead to discussion. Too narrow or too ambiguous and they invite questions and clarification and the resulting outputs tend to lose relevance. It’s also good to have more than one topic, whether each one is a slight variation on a single theme that focuses attention on different aspects of a problem or opportunity or whether they direct thinking toward a particular type of solution. Having multiple topics ‘up your sleeve’ enables the moderator to quickly move forward if a topic stalls or is failing to inspire participants. Using the syntax ‘How might we…’ to preface pithy topic is also effective to spur creative thinking.
Having dealt with the logistics and identifying strong ideation challenges, focus shifts to the defining the right structure for the session and identifying a set of ideation challenge cards that are most relevant to the topic at hand (See below). Structure can be loose, especially if participants have been involved in sessions before. Generally, too much structure and timeboxing of individual activities reduces group output, similarly, too loose and the sessions can lack direction, often resulting in a dominant participant taking the lead and implicitly or explicitly taking over.
Nine square grids (either paper or digital) are printed out or originated digitally for each participant and for each round of challenges. Five participants and three rounds will need fifteen grids prepared, three sets of challenge cards for each participant and the agreed ideation topic.
The sessions themselves ideally start with a recap of any supporting insights and domain research. This is a good framing activity to get participants thinking about the topic. Sometimes, an icebreaker activity is also used at the start of the session. Then the ideation topic is presented to the group. It’s good to present this in quite a factual almost official manner without prompting clarifications and allowing for the silence that follows while people cogitate on the problem.
The first challenge round starts when each participant turns over (paper) or makes the text font visible (digital) to reveal the challenge. The moderator the asks the group to spend one-minute writing or sketching an idea in each square of the grid. Ideas can take any form, from an image that represents the concept, a short phrase on a sticky note or even a sketch or illustration. In all cases the ideas must be quickly identified and noted down, as to avoid overthinking the possible constraints of a given digital platform. Showing examples of good outputs in their rawest from is a good way to get participants in the right mindset where they are neither too precious about creating high-quality drawings, clever one-liners or overly long detailed, descriptions.
During the eight minutes that participants are producing ideas the moderator keeps time as well as keeping the group focused on the activity, sharing strong ideas with the group and generally keeping momentum. Sometimes, ideas are shared out among the group if time permits and, in some cases, voting can be done to quickly prioritise outputs. The process is then repeated until all the challenge cards have been used.
Challenge cards are pre-defined physical postcard sized boards or sticky notes (including digital variants) that are placed on the first square of the ideation grid. This is usually the top left square but position is not as important as ensuring participants understand the challenge. The cards instruct participants to ideate on the focus of the card. Running multiple rounds using different challenges produces large numbers of ideas and potential solutions that cover a broader range of options. Ideas from single rounds are often more obvious and are already known by participants. This can inhibit creative thinking as participants have invested in ideas before the session and are sometime reluctant to shift focus. Using the ‘What if..’ syntax to preface the challenge helps provide consistency and also helps spur thinking in the direction of the challenge.
Challenge cards help break the ‘primary generator’ effect [17] whereby participants lock onto one idea (usually the first one they think of) that blocks thinking of alternatives. Challenges also help to clear out the most obvious solutions from consideration, so that participants can shift focus to less obvious ones and novelty. As the challenges are predefined and used by all participants they also act as a leveller reducing scrutiny and encouraging people to produce many ideas rather than worrying if theirs are inferior to others. Predefined timeframes can also be used to catalyse thinking about a particular even horizon in the future and in some cases the past, to see if an existent idea could be reused. Other challenge strategies include laddering whereby each grid square is used to show incremental developments from each idea to another. This is effective in clearing out presumptions about what is possible and encourages more creativity. Similarly, linking uses the grid to show individual ideas developed by adding or removing elements from one to another. This is a very practical way of ideating on a practical situation where a problem or opportunity is deeply embedded in an organisation and its culture.
Starting by eliciting the most obvious ideas is a good opening framing activity and is also effective icebreaker. Asking for the most mundane, boring, unexciting ideas encourages participants to share ideas openly and usually garners some humour. It also level-sets what is acceptable as an idea and reduces judgement as everyone usually has an obvious idea they endorse but are usually reticent to share as it is so obvious. It also sets an implicit anchor point for subsequent stages. At a deeper level, top-of-mind ideas also offer valuable insights into participant’s understanding of the ideation topic and can be used through output analysis to map out the current situation and ‘as-is’ solutions as a starting point for more future oriented activities. Ideas are not just starting points for change but also embody a specific mindset and articulation of a problem or opportunity.
This challenge often produces the most potent ideas in ideation sessions. The randomly generated nature of the resulting concepts are almost always novel and are usually readily built upon by participants in the sessions, creating even more ideas [13]. The random nature of their genesis helps reduced ownership as they are attributed to the method rather than the individuals who identified them. This challenge applies classic analogous thinking and can be done in one or multiple stages depending on participants readiness. At the same time, participants can sometimes baulk at being asked to engage in what often seems as a rather odd diversion activity. Moderators often have to make a call on whether to stick to the method or, if the group is already catalysed to ideate, to go with the flow.
This challenge requires an additional step by the moderator. Firstly, before the session a number of random stimuli topics are identified that will be used to trigger analogous thinking. An arbitrary word, picture, or even sound is chosen as a catalyst to stimulate new and engender lateral ways of thinking about a problem or opportunity (e.g. how might we reduce packaging). The predefined stimuli, (e.g. Tiger), helps ideators’ anchor thinking outside conventional boundaries by forcing convergence on a single and unrelated topic. Participants write down characteristics pertaining to the stimulus (e.g. fierce, endangered, alert, fast etc.) in order to think divergently. Participants then apply these characteristics to the problem at hand. In this example, alert and fast characteristics could stimulate ideas around
Having up to six random stimuli helps if one fails. Diversity is important too, a good set might comprise widely disparate topics such as, ant, airport, light, Curie, satellite and eagle, for example. An alternative way of introducing randomness is to pick subjects arbitrarily from a book and also using oblique strategies [18] for reframing.
Having harvested the most obvious ideas and applied lateral thinking through random input to elicit less obvious ones, it’s good to reign in thinking back to focus on the ideation topic with time as the variable. The time horizon can be very specific and focus on a particular date in the near or distant future or be more ambiguous. Too distant dates tend to elicit ideas you might find in science fiction that while entertaining tend to trivialise the activity and limits practical solution ideas. Similarly, too near timelines result in trivial outcomes often, Using multiple dates in rounds is affective too as does including a range. A very close by date that encourages quick fixes, a mid-point and near future is a good set to get ideas form. Lookback is a variation on this challenge based on Bill Buxton’s innovation model [19]. In this case ideas are based on reverse-engineering and looking for historical precedence to current or future problems or solutions that are the same or similar to the ideation topic.
This challenge usually produces the strongest and most viable ideas in session and ideally should be applied at the later stages of a session after the obvious and ‘blue-sky’ ideas have already been elicited. It involves participants creating eight alternative solutions to the same ideation topic, with a prompt along the lines of ‘now give us your best ideas’. Sessions can exploit the competitive potential of this method, by voting and awarding the best ideas (not participants themselves) including the most mundane, most lateral, quickest win and best overall solution. Dot voting is an effective way of doing this and also minimised group dynamics that might bias outcomes [20].
Ideation Grids embody a design tradition built on aligning innovation to human values. They are also an effect and practical tool to support any organisation wishing to harness the power of crowdsourcing ideas. While there is an art to maximising the method’s effectiveness through skills and expertise in identifying the right ideation topic, selecting participants, defining challenges, moderating and analysing outcomes, they are simple enough for anyone to get started with and leverage the power of creative collaboration to ideate. This method was developed for face-to-face ideation sessions where close interactions between participant are enriched through natural by non-verbal communication. However, we have applied this method successfully during the Covid-19 pandemic with remote participants connected through digital platforms. We found that group dynamic effects were reduced, and that the affordances of digital mediums improved group working; making documentation of outputs easier and enabling the possibility of leveraging globally diverse participants across multiple sessions a practical reality.
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nOAI-PMH
\\n\\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\\n\\nLicense
\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\\n\\nPeer Review Policies
\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
\\n\\nOA Publishing Fees
\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\nDigital Archiving Policy
\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. 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Cells encode “receptors” containing Ub-/Ubl-binding domains that interpret and translate each modification into appropriate cellular responses. Among the different Ubls, NEDD8, which is the ubiquitin’s closest relative, retains many of the structural determinants that enable ubiquitin the ability to target proteins to degradation. Nevertheless, the direct involvement of NEDD8 conjugation to proteasome recruitment has been proved only in a few cases. To date, well-defined major NEDD8 substrates are primarily members of the cullin family, and cullin neddylation does not appear to mark these proteins for degradation. Various studies have demonstrated that selectivity between ubiquitin and NEDD8 is guaranteed by small but substantial differences. Nevertheless, several issues still need to be addressed, mainly concerning which interaction surfaces mediate NEDD8 function and what domains recognize them. Recently, two novel domains identified in KHNYN and N4BP1 proteins have shed new light on this research area. Here, I discuss some recent reports that contributed to shed light on the mechanisms underlining the discrimination between ubiquitin and NEDD8. Understanding the details of these molecular mechanisms represents a prominent facet for the identification of new therapeutic targets.",book:{id:"8301",slug:"ubiquitin-proteasome-system-current-insights-into-mechanism-cellular-regulation-and-disease",title:"Ubiquitin Proteasome System",fullTitle:"Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease"},signatures:"Elena Santonico",authors:[{id:"271923",title:"Dr.",name:"Elena",middleName:null,surname:"Santonico",slug:"elena-santonico",fullName:"Elena Santonico"}]},{id:"28199",doi:"10.5772/31082",title:"F0F1 ATP Synthase: A Fascinating Challenge for Proteomics",slug:"f0f1-atp-synthase-a-fascinating-challenge-for-proteomics",totalDownloads:5574,totalCrossrefCites:2,totalDimensionsCites:8,abstract:null,book:{id:"780",slug:"proteomics-human-diseases-and-protein-functions",title:"Proteomics",fullTitle:"Proteomics - Human Diseases and Protein Functions"},signatures:"Federica Dabbeni-Sala, Amit Kumar Rai and Giovanna Lippe",authors:[{id:"85523",title:"Prof.",name:"Giovanna",middleName:null,surname:"Lippe",slug:"giovanna-lippe",fullName:"Giovanna Lippe"},{id:"149272",title:"Dr.",name:"Federica",middleName:null,surname:"Dabbeni-Sala",slug:"federica-dabbeni-sala",fullName:"Federica Dabbeni-Sala"},{id:"149273",title:"Dr.",name:"Amit",middleName:null,surname:"Kumar Rai",slug:"amit-kumar-rai",fullName:"Amit Kumar Rai"}]},{id:"65025",doi:"10.5772/intechopen.82883",title:"E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting",slug:"e3-ubiquitin-ligases-in-cancer-and-their-pharmacological-targeting",totalDownloads:1693,totalCrossrefCites:2,totalDimensionsCites:8,abstract:"Ubiquitination plays many critical roles in protein function and regulation. Consequently, mutation and aberrant expression of E3 ubiquitin ligases can drive cancer progression. Identifying key ligase-substrate relationships is crucial to understanding the molecular basis and pathways behind cancer and toward identifying novel targets for cancer therapeutics. Here, we review the importance of E3 ligases in the regulating the hallmarks of cancer, discuss some of the key and novel E3 ubiquitin ligases that drive tumor formation and angiogenesis, and review the clinical development of inhibitors that antagonize their function. We conclude with perspectives on the field and future directions toward understanding ubiquitination and cancer progression.",book:{id:"8301",slug:"ubiquitin-proteasome-system-current-insights-into-mechanism-cellular-regulation-and-disease",title:"Ubiquitin Proteasome System",fullTitle:"Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease"},signatures:"Joseph Y. Ong and Jorge Z. Torres",authors:[{id:"186645",title:"Dr.",name:"Jorge",middleName:null,surname:"Torres",slug:"jorge-torres",fullName:"Jorge Torres"},{id:"264944",title:"Mr.",name:"Joseph",middleName:null,surname:"Ong",slug:"joseph-ong",fullName:"Joseph Ong"}]},{id:"28201",doi:"10.5772/31113",title:"Identification of the Novel Plasminogen Receptor, Plg-RKT",slug:"identification-of-the-novel-plasminogen-receptor-plg-rkt",totalDownloads:2452,totalCrossrefCites:1,totalDimensionsCites:5,abstract:null,book:{id:"780",slug:"proteomics-human-diseases-and-protein-functions",title:"Proteomics",fullTitle:"Proteomics - Human Diseases and Protein Functions"},signatures:"Lindsey A. Miles, Nicholas M. Andronicos, Emily I. Chen, Nagyung Baik, Hongdong Bai, Caitlin M. Parmer, Shahrzad Lighvani, Samir Nangia, William B. Kiosses, Mark P. Kamps, John R. Yates III and Robert J. Parmer",authors:[{id:"85634",title:"Dr.",name:"Lindsey A.",middleName:null,surname:"Miles",slug:"lindsey-a.-miles",fullName:"Lindsey A. 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Yates, III"},{id:"85781",title:"Dr.",name:"Robert J.",middleName:null,surname:"Parmer",slug:"robert-j.-parmer",fullName:"Robert J. Parmer"},{id:"123594",title:"Dr.",name:"Samir",middleName:null,surname:"Nangia",slug:"samir-nangia",fullName:"Samir Nangia"},{id:"123595",title:"Dr.",name:"Shahrzad",middleName:null,surname:"Lighvani",slug:"shahrzad-lighvani",fullName:"Shahrzad Lighvani"}]}],mostDownloadedChaptersLast30Days:[{id:"70577",title:"Proteoforms: General Concepts and Methodological Process for Identification",slug:"proteoforms-general-concepts-and-methodological-process-for-identification",totalDownloads:939,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The term proteoform is used to denote all the molecular forms in which the protein product of a single gene can be found. The most frequent processes that lead to transcript modification and the biological implications of these changes observed in the final protein product will be discussed. Proteoforms arising from genetic variations, alternatively spliced RNA transcripts and post-translational modifications will be commented. This chapter will present an evolution of the techniques used to identify the proteoforms and the importance of this identification for understanding of biological processes. This chapter highlights the fundamental concepts in the field of top-down mass spectrometry (TDMS), and provides numerous examples for the use of knowledge obtained from the identification of proteoforms. The identification of mutant proteins is one of the emerging areas of proteogenomics and has the potential to recognize novel disease biomarkers and may point to useful targets for identification of therapeutic approaches.",book:{id:"9352",slug:"proteoforms-concept-and-applications-in-medical-sciences",title:"Proteoforms",fullTitle:"Proteoforms - Concept and Applications in Medical Sciences"},signatures:"Jucélia da Silva Araújo and Olga Lima Tavares Machado",authors:[{id:"30130",title:"Dr.",name:"Olga Lima Tavares",middleName:null,surname:"Machado",slug:"olga-lima-tavares-machado",fullName:"Olga Lima Tavares Machado"},{id:"310148",title:"Dr.",name:"Jucelia",middleName:null,surname:"Da Silva Araujo",slug:"jucelia-da-silva-araujo",fullName:"Jucelia Da Silva Araujo"}]},{id:"65025",title:"E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting",slug:"e3-ubiquitin-ligases-in-cancer-and-their-pharmacological-targeting",totalDownloads:1693,totalCrossrefCites:2,totalDimensionsCites:8,abstract:"Ubiquitination plays many critical roles in protein function and regulation. Consequently, mutation and aberrant expression of E3 ubiquitin ligases can drive cancer progression. Identifying key ligase-substrate relationships is crucial to understanding the molecular basis and pathways behind cancer and toward identifying novel targets for cancer therapeutics. Here, we review the importance of E3 ligases in the regulating the hallmarks of cancer, discuss some of the key and novel E3 ubiquitin ligases that drive tumor formation and angiogenesis, and review the clinical development of inhibitors that antagonize their function. We conclude with perspectives on the field and future directions toward understanding ubiquitination and cancer progression.",book:{id:"8301",slug:"ubiquitin-proteasome-system-current-insights-into-mechanism-cellular-regulation-and-disease",title:"Ubiquitin Proteasome System",fullTitle:"Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease"},signatures:"Joseph Y. Ong and Jorge Z. Torres",authors:[{id:"186645",title:"Dr.",name:"Jorge",middleName:null,surname:"Torres",slug:"jorge-torres",fullName:"Jorge Torres"},{id:"264944",title:"Mr.",name:"Joseph",middleName:null,surname:"Ong",slug:"joseph-ong",fullName:"Joseph Ong"}]},{id:"65109",title:"Ubiquitin Signaling in Regulation of the Start of the Cell Cycle",slug:"ubiquitin-signaling-in-regulation-of-the-start-of-the-cell-cycle",totalDownloads:1595,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"The small protein ubiquitin plays a vital role in virtually all aspects of cellular life. Among the diverse signaling outcomes associated with ubiquitination, the most well-established is the targeted degradation of substrates via the proteasome. During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. In particular, ubiquitin-mediated degradation is critically important at transition points where it provides directionality and irreversibility to the cell cycle, which is essential for maintaining genome integrity. Specifically, the boundary between G1 and S-phase is tightly regulated by the ubiquitin proteasome system. Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation.",book:{id:"8301",slug:"ubiquitin-proteasome-system-current-insights-into-mechanism-cellular-regulation-and-disease",title:"Ubiquitin Proteasome System",fullTitle:"Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease"},signatures:"Michael James Emanuele and Taylor Paige Enrico",authors:[{id:"264977",title:"Dr.",name:"Michael",middleName:null,surname:"Emanuele",slug:"michael-emanuele",fullName:"Michael Emanuele"},{id:"282200",title:"Ms.",name:"Taylor",middleName:null,surname:"Enrico",slug:"taylor-enrico",fullName:"Taylor Enrico"}]},{id:"60432",title:"Protein-Based Detection Methods for Genetically Modified Crops",slug:"protein-based-detection-methods-for-genetically-modified-crops",totalDownloads:1463,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"The generation of genetically modified (GM) crops is rapidly expanding each and every year around the world. The well-being and quality assessment of these harvests are vital issues with respect to buyers’ interests. This drove the administrative specialists to execute an arrangement of extremely strict strategies for the endorsement to develop and use GMOs and to produce an interest in scientific techniques equipped for identifying GM crops. The GM crops have been added to the effective fuse of various attributes by presenting transgenes, for example, Bacillus thuringiensis (Bt) insecticidal qualities, in various crop species. GM crops give critical financial, natural, well-being and social advantages to both small and large agriculturists. The detection strategies incorporate either DNA-based or protein-based measures. Different immunoassays or catalyst connected immunosorbent tests are delicate and more affordable; however, they need experienced technicians. A very simple method, that is, immunochromatographic (ICS) test, is set up in the world, which is modest, compact and simple to utilize. The ICS is a semiquantitative method for indicative screening and semi-measurement of new remote proteins presented through hereditary change of plants. The strip is the easiest method for the assessment of several Bt crop plants for insecticidal quality.",book:{id:"6635",slug:"protein-protein-interaction-assays",title:"Protein-Protein Interaction Assays",fullTitle:"Protein-Protein Interaction Assays"},signatures:"Kausar Malik, Haleema Sadia and Muhammad Hamza Basit",authors:[{id:"238750",title:"Prof.",name:"Kausar",middleName:null,surname:"Malik",slug:"kausar-malik",fullName:"Kausar Malik"},{id:"243713",title:"Dr.",name:"Haleema",middleName:null,surname:"Sadia",slug:"haleema-sadia",fullName:"Haleema Sadia"},{id:"243714",title:"Mr.",name:"Muhammad Hamza",middleName:null,surname:"Basit",slug:"muhammad-hamza-basit",fullName:"Muhammad Hamza Basit"}]},{id:"60064",title:"Rapid Endosomal Recycling",slug:"rapid-endosomal-recycling",totalDownloads:1358,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"Peripheral membrane proteins are endocytosed by constitutive processes of membrane invaginations, followed by internalization driven by diverse endocytic machinery available at the cell surface. It is believed that after endocytic uptake, cargo proteins proceed either through the endosomal recycling circuit of the cell or travel toward late endosomes for degradation. In this chapter, we analyzed trafficking of seven cargo molecules (transferrin receptor, fully conformed MHC-I, non-conformed MHC-I, cholera-toxin B subunit, CD44, ICAM1, and G-protein-coupled receptor Rae-1) known to use the distinct endocytic route. For that purpose, we developed the software for multicompartment analysis of intracellular trafficking. We demonstrate that all endocytosed molecules are rapidly recycled and propose that the rapid recycling is a constitutive process that should be considered in the analysis of intracellular trafficking of peripheral membrane proteins.",book:{id:"6649",slug:"peripheral-membrane-proteins",title:"Peripheral Membrane Proteins",fullTitle:"Peripheral Membrane Proteins"},signatures:"Hana Mahmutefendić, Gordana Blagojević Zagorac, Senka Maćešić\nand Pero Lučin",authors:[{id:"152008",title:"Prof.",name:"Pero",middleName:null,surname:"Lučin",slug:"pero-lucin",fullName:"Pero Lučin"},{id:"245873",title:"Prof.",name:"Hana",middleName:null,surname:"Mahmutefendić",slug:"hana-mahmutefendic",fullName:"Hana Mahmutefendić"},{id:"245875",title:"Prof.",name:"Gordana",middleName:null,surname:"Blagojević Zagorac",slug:"gordana-blagojevic-zagorac",fullName:"Gordana Blagojević Zagorac"},{id:"245876",title:"Prof.",name:"Senka",middleName:null,surname:"Maćešić",slug:"senka-macesic",fullName:"Senka Maćešić"}]}],onlineFirstChaptersFilter:{topicId:"152",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:18,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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