\r\n\tThere will be a chapter on secondary causes of sexual dysfunction disorders related to diabetes, cardiovascular disease, and obesity. A chapter on remedial measures to enhance sexual activity and maintain human relationships will be discussed. As there is a growing number of cancer survivors a chapter on cancer-related sexual dysfunction will be welcomed for including it.
",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"b988fda30a4e2364ee9d47e417bd0ba9",bookSignature:"Dr. Dhastagir Sultan Sheriff",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11889.jpg",keywords:"Sex, Sexual Response Cycle, Erection, Premature Ejaculation, Libido, Orgasm, Painful Intercourse, Psychological, Female, Lack of Desire, Erectile Disorders, Pain Disorders",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 8th 2022",dateEndSecondStepPublish:"May 6th 2022",dateEndThirdStepPublish:"July 5th 2022",dateEndFourthStepPublish:"September 23rd 2022",dateEndFifthStepPublish:"November 22nd 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dhastagir Sultan Sheriff is a life member of the European Society for Human Reproduction and Early Human Development, Association of Physiologists and Pharmacologists of India, member of the National Academy of Medical Sciences, New Delhi, and resource person for UNESCO for Medical and Bioethics. Dr. Sheriff has authored five books including a textbook on medical biochemistry with additional interest in human sexology. He has done extensive research in andrology, sex education, and counseling.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"167875",title:"Dr.",name:"Dhastagir Sultan",middleName:null,surname:"Sheriff",slug:"dhastagir-sultan-sheriff",fullName:"Dhastagir Sultan Sheriff",profilePictureURL:"https://mts.intechopen.com/storage/users/167875/images/system/167875.jpg",biography:"Dhastagir Sultan Sheriff is a life member of the European Society for Human Reproduction and Early Human Development, Association of Physiologists and Pharmacologists of India, member of the National Academy of Medical Sciences, New Delhi, and resource person for UNESCO for Medical and Bioethics. Dr. Sheriff has authored five books including a textbook on medical biochemistry with additional interest in human sexology. He had editorials written in the British Journal of Sexology, Journal of Royal Society of Medicine, Postgraduate Medicine, and Scientist. He was a former Rotarian, Citizen Ambassador, and was selected for the Ford Foundation Fellowship.",institutionString:"University of Benghazi",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Benghazi",institutionURL:null,country:{name:"Libya"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:null},relatedBooks:[{type:"book",id:"6934",title:"Psycho-Social Aspects of Human Sexuality and Ethics",subtitle:null,isOpenForSubmission:!1,hash:"44731b106aa0d1ab5c64a7394483c7d5",slug:"psycho-social-aspects-of-human-sexuality-and-ethics",bookSignature:"Dhastagir Sultan Sheriff",coverURL:"https://cdn.intechopen.com/books/images_new/6934.jpg",editedByType:"Edited by",editors:[{id:"167875",title:"Dr.",name:"Dhastagir Sultan",surname:"Sheriff",slug:"dhastagir-sultan-sheriff",fullName:"Dhastagir Sultan Sheriff"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7163",title:"Infertility, Assisted Reproductive Technologies and Hormone Assays",subtitle:null,isOpenForSubmission:!1,hash:"6db6e4ccb7088f17f819121f7eb6424d",slug:"infertility-assisted-reproductive-technologies-and-hormone-assays",bookSignature:"Dhastagir Sultan Sheriff",coverURL:"https://cdn.intechopen.com/books/images_new/7163.jpg",editedByType:"Edited by",editors:[{id:"167875",title:"Dr.",name:"Dhastagir Sultan",surname:"Sheriff",slug:"dhastagir-sultan-sheriff",fullName:"Dhastagir Sultan Sheriff"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. 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In the process of operation, the marine riser bears the impact, erosion and other damage of seawater, and it needs to be repaired or renewed frequently. Its service life is only 2–3 years. Marine riser related technology has become one of the main obstacles to human being’s deep-sea development. As the key structure connecting floating platform and underwater production system, marine riser generally bears the axial tension. The lower end connects with the seabed wellhead through the universal joint, and the upper end is coordinated with the slip joint on the platform or the bottom of the ship to carry out drilling, liquid guiding, mud guiding and other work. It is a necessary equipment for the deep-sea oil and gas development and transportation. In deep-sea environments, currents passing through the riser may induce the rear edge of the riser releasing the vortex alternately, known as “Karman vortex street”. The presence of “Karmen vortex street” causes the riser structure vibrating simultaneously in the cross-flow (CF) and the in-line (IL) directions, and the vibration of the riser will in turn change the vortex characteristics of the flow field. This phenomenon of fluid structure interaction is called “VIV”. When the frequency of vortex release is close to the natural frequency of the riser structure, the phenomenon of “Lock-in” occurs. With the significant increase of the vibration amplitude of the riser, fatigue damage and even failure of the riser structure are often caused. In 2011, the “Gannet Alpha” drilling platform of shell oil company on the North Sea area of the United Kingdom suffered a sudden accident, resulting in the fatigue fracture of the oil pipeline connected with the platform. As a result, about 21.6 billion tons of crude oil leaked into the sea, causing serious pollution to the surrounding environment and causing major economic losses. However, the strong non-linearity, non-stationarity and uncertainty of the VIV of marine riser make it extremely difficult to predict the VIV of marine riser. How to accurately predict the VIV of marine riser and provide a more comprehensive theoretical basis for the design and daily maintenance of marine riser has been an ideal goal pursued by engineers and scientists.
Schematic diagram of marine riser operation.
For the study of VIV of marine riser, early scholars started from the simplest riser section, and now they have carried out a very rich experimental and numerical simulation study on two-dimensional (2D) rigid cylinder, including the study of flow around fixed cylinder, forced vibration and self-excited vibration of cylinder. The study of a rigid cylinder VIV (2D VIV) establishes many basic concepts of VIV, explores the law of rigid cylinder VIV, and lays a foundation for the construction of three-dimensional (3D) riser VIV algorithm model. However, the vibration of marine riser shows the characteristics of high order vibration and the vortex released by the rear edge of the riser has obvious 3D characteristics. Therefore, the research results based on the 2D VIV fail to provide complete technical support for the 3D marine riser. This prompted the researchers to study the VIV of 3D marine riser based on the research results of a rigid cylinder VIV. Due to the different emphases of the study on the VIV of a rigid cylinder and slender flexible riser, there are also many differences in the research methods and research hotspots. So far, there have been abundant researches on VIV, and many reviews have summarized the results of studies on the VIV of a rigid cylinder or a riser. For example, Williamson [1], Williamson and Govardhan [2, 3], Sarpkaya [4], Gabbai and Benaroya [5], Bearman [6], Wu et al. [7] have summarized the research results of a cylindrical structure or a riser VIV in recent decades. In this chapter, the numerical simulation study of marine riser VIV in recent decades are summarized, and the development process, advantages and disadvantages of different numerical research methods are analyzed and summarized. Finally, the research progress of current basic research and hot issues in engineering practice is discussed. The numerical analysis methods of marine riser are mainly divided into two categories: one is the empirical model method based on experimental data, the other is the numerical simulation method based on computational fluid dynamics (CFD) and computational structure dynamics (CSD).
The numerical prediction method based on empirical model is suitable for solving practical engineering problems, because the physical model is clear, and the calculation is simple. Empirical models mainly include wake oscillator model, modal superposition model, statistical model, etc. Among them, wake oscillator model and its improvement model are most widely used. Bishop and Hassan [8] and Hartlen and Currie [9] proposed the wake oscillator model and described the hydrodynamic force with the nonlinear Van de Pol equation. In the model, the hydrodynamic equation is coupled with the vibration equation which describes the transverse VIV of the structure. This model can simulate many phenomena in the experiment qualitatively. Iwan and Blevins [10] and Iwan [77] deduced the coupling equation of wake oscillator and structural motion based on momentum conservation principle. The model has clear physical meaning and well reflects the hydrodynamic characteristics of VIV. The empirical parameters in the equation are determined by the test results of forced vibration. Therefore, the wake oscillator model is highly dependent on the empirical coefficient, and the empirical parameters selected by different wake oscillator models are greatly different. Therefore, even for the same research object, the prediction results of different wake oscillators are also significantly different. As demonstrated by Chaplin et al. [11], the amplitude response predicted by fourteen empirical models for the prediction of VIV in the same physical experiment is smaller than the experimental value, and the prediction results of each empirical model are also significantly different. The wake oscillator model has been widely accepted as a mainstream semi-empirical and semi-theoretical algorithm for a long time. However, the inherent deficiency of the algorithm lies in that the hydrodynamic frequency of the algorithm is obtained mainly through the calculation of the St number (St) obtained by the experiments of fixed circular cylinder. However, the frequency of hydrodynamic force of circular VIV of cylinder differs greatly from the frequency corresponding to the St number in the flow around the fixed cylinder. Therefore, in most cases, this algorithm can only obtain qualitative results, and its accuracy is greatly different from the experimental results. Facchinetti et al. [12] improved the dynamic characteristics of the wake oscillator model and, respectively, considered the coupling effect of displacement, velocity and acceleration on the wake oscillator. By comparing the prediction results of different coupling modes with the experimental results, it is found that the coupling of acceleration and lift induced by vortices can reflect the VIV characteristics of rigid cylinders quantitatively. Facchinetti et al. [13] further extended the model and applied it to VIV response of slender flexible cables. Mathelin and Langre [14] extend the work of Facchinetti et al. [13] to predict VIV response in shear flow. Furnes and Sørensen [15], Ge et al. [16] and Li et al. [17] proposed the simulation of dual-coupling oscillator model to simulate flow direction and transverse pulse dynamics, but the wake oscillator processed separately in both directions could not accurately predict the phase difference between flow direction and transverse response. Srinil [18] and Srinil and Zanganeh [19] used a double duffing-van der Pol oscillator to predict VIV responses to flow and lateral coupling. The model can predict the amplitude response of flow direction and transverse VIV more successfully. In general, the empirical model approach does not consider the specific flow field structure, but directly considers the flow field and structure as a whole system. A set of equations is used to describe the characteristics of the whole system, which has the advantages of simple model, wide application range, and low requirement for computing power and storage capacity of the computer. However, this set of equations has many parameters, and the selection of these parameters is determined by experience or experiment. The choice of these parameters is crucial to the result, and the choice of parameters of different empirical models varies greatly. How to apply forced and self-excited vibration test data under specific conditions has not been completely solved, which constitutes a major shortcoming of the empirical model method. In addition, the empirical model is mainly applied to the prediction of VIV response of riser, which is not suitable for the study of VIV mechanism, wake vortex law and fluid-solid coupling characteristics of riser.
Numerical simulation of 2D VIV can be divided into two aspects. On the one hand, how to simulate the numerical results and phenomena which match the physical experiments; on the other hand, the intrinsic mechanism of VIV is studied by numerical simulation. In the study of a cylinder VIV, there are two topics that attract most attention: one is the super upper branch, and another is phase jump.
Jauvtis and Williamson [20, 21] studied the VIV characteristics of a cylindrical structure at low mass and damping with 2 DOF and found that when the mass ratio m* dropped to 2.6, the 2 DOF system got a super upper branch of transverse response amplitude, the largest response amplitude reaching 1.5 D, which all previous experiments had failed to get, and the “2T” vortex mode corresponding to the maximum transverse amplitude is observed.
Blevins and Coughran [22] adopted the physical experiment method to study comprehensively the VIV of cylindrical structure for 1 DOF and 2 DOF with variable mass ratio, damping, and found that the measured maximum amplitude was 1.75 D for a smooth 2 DOF cylinder at Reynolds number of 139,000. Based on experimental study, many scholars have carried out numerical study of VIV. Most scholars have used 2D numerical simulation to study the VIV of a cylindrical structure with low mass-damping [23, 24, 25, 26]. For Re = 100–200, numerical simulations [23, 24, 25, 26], including our previous research [27, 28, 29], gave similar amplitude results (Ay/D = 0.6) which were lower than the expected values. Subsequently, some scholars simulated the VIV of a cylindrical structure with Re = 1000, with the amplitude of transverse vibration reaching a value of Ay/D = 0.7. All these numerical simulations were carried out at low Reynolds numbers, well below the Reynolds numbers used in the classic experiment [21]. For this reason, numerical simulation seemed to capture only the initial and lower branches, whereas the upper and super upper branches were absent. Recently, some scholars began to use numerical simulation methods to study the VIV of a cylindrical structure at Reynolds numbers matched with the classic experimental values. Guilmineau and Queutey [30] used the incompressible two-dimensional Reynolds-Averaged Navier-Stokes (RANS) scheme to simulate the VIV of an elastically mounted rigid cylinder with low mass-damping, constrained to oscillate transversely to a free stream and compared their results with compared with the 1996 experimental results of Khalak and Williamson [31]. According the initial condition used, the simulations predict correctly the maximum amplitude. On the other hand, the numerical results do not match the upper branch found experimentally. However, these results are encouraging, because no simulations have yet predicted such a high amplitude of vibration. Wanderley et al. [32] used the Roe-Sweby scheme to solve the compressible RANS equations to simulate the VIV of an elastically mounted rigid cylinder for 1 DOF with the mass ratio m* = 1.8. The numerical results obtained in the present work agree remarkably well with experimental data obtained from the literature (Khalak and Williamson [31]) which the mass ratio was equal to 2.4 and captured the corresponding response branch and vortex patterns. Pan et al. [33] also adopted the incompressible two-dimensional RANS scheme to simulate the VIV of an elastically mounted rigid cylinder for 1 DOF with the mass ratio m* = 2.4, and the result was compared with the experimental data reported by Khalak and Williamson [31]. The absence of the upper branch in RANS simulations is explained in depth because of discrepancies, which exist between experiments and RANS simulations. Srinil et al. [34] presents an experimental and numerical investigation of an elastically mounted rigid cylinder for 2 DOF with variable nature frequency ratios fx/fy and reported that when fx/fy =1.0 and mass ratio m* = 3.5, the transverse amplitude of the numerical simulation was much smaller than that of the experimental value. Gsell et al. [35] investigated the VIVs of an elastically mounted circular cylinder using a direct numerical simulation method. In the upper branch, the maximum amplitude predicted by the simulation at U* = 6.5 (about 1.2D) is lower than the amplitude measured experimentally [21] at the same reduced velocity. The author thinks that some deviations are expected due to the difference in the value of Re. Zhao and Cheng [36, 37] used the incompressible two-dimensional Reynolds-Averaged Navier-Stokes scheme to obtain the super upper branch and 2T vortex shedding pattern with initial conditions of velocity increasing constantly, which was in a good agreement with the experimental results [21]. Li et al. [38] adopted two typical turbulent models to simulate the VIV of a cylindrical structure for 1 DOF, and the predicted maximum amplitude was lower than that obtained by Khalak and Williamson [31]. Kang et al. [39] applied a modified SST model based on OpenFOAM to simulate experimental results [21] and it captured the maximum amplitude reaching values of 1.4 D when the entrance velocity was made to increase constantly in the process of numerical simulation. In previous studies [36, 37, 39], the initialization of numerical simulation started from the entrance, the inflow velocity is increased gradually from 0 or one low velocity value to the target value at a constant acceleration value and then is kept constant. The results show that the maximum transverse amplitude can be captured more accurately with appropriate inflow acceleration value. The value of this acceleration is usually very small, it takes a long time to accelerate to the target value, and how to determine the appropriate value of acceleration needs to be tested. Using this method to simulate the upper branch, the workload and computation time of is very large. Han et al. [40] successfully capture the initial branch, the lower branch, and the super upper branch with more accurate results, as shown in Figure 2. The units of each coordinate axis in the figure are dimensionless. The corresponding reduced velocity range of each branch is consistent with the classical experimental results [21]. The maximum value of the super upper branch is 1.46 D.
Response amplitudes of the transverse directions under different reduced velocities [
The vortex pattern at different reduced velocities is simulated successfully, as shown in Figure 3. The VIV of the streamwise direction is in a resonance state at a low reduced velocity and the vortex pattern in the wake is a symmetric pair in vortex modes. With the increase in reduced velocity, the transverse amplitude increases continuously, the cylindrical structure response enters the super upper branch, and the vortex pattern switches from 2S to 2T. When the reduced velocity increases further, the cylindrical structure’s response enters the lower branch and the vortex pattern becomes 2P. With further increase in the reduced velocity, the transverse amplitude decreases continuously, and the vortex pattern becomes 2S.
Vorticity contours under different reduced velocity [
Previous work has also shown phase differences between lift and CF displacements. In 1964, Bishop and Hassan [8] experimented on the lateral forced oscillation of a cylinder in a uniform flow, identifying the important phenomenon that when a cylinder oscillation frequency is near a natural vortex shedding frequency, the phase difference of the cylinder lift and the CF response undergoes a “sudden” jump from an “out-of-phase” mode to an “in-phase” mode. Then, Sarpkayab [41, 42], Bearman and Currie [43], Gopalkrishnan [44], and Carberry et al. [45] conducted similar experiments and reported the same phenomenon. The experimental study of Carberry et al. showed that in the process of a cylinder oscillating from a low frequency area (lower than the natural vortex shedding frequency) to a high frequency area (higher than the natural vortex shedding frequency), there is a transition zone. In the transition zone the mode of the vortex wake changes and at the same time the phase difference of the lift and CF responses undergoes a “sudden” jump. Sarpkaya [41] concluded that the phase difference between the lift and CF responses was closely related to an energy transfer between the cylinder and fluid. Zdravkovich [46] used visual means to analyze the previously studied flow field and found that a phase difference between the lift and CF responses was related to the vortex shedding time. Ongoren and Rockwell [47] used visualization analysis and reached a similar conclusion. Gu et al. [48] pointed out that with an increase in the frequency ratio, at a certain critical frequency, compared with the initial time, the cylindrical vortex shedding jumped from one side to another. Previous research has also shown that a phase difference between the cylinder lift and displacement, which determines the amplitude of a cylinder vibration, is related to the energy transfer between the cylinder and fluid. Govardhan and Williamson [49] used the particle image velocimetry method to study transverse VIVs and highlighted that the phase remained slightly above throughout the initial and upper branch regimes and jumps of almost occurred throughout the upper and lower branch. Guilmineau and Queutey [30] used the RANS method to simulate a cylindrical CF forced oscillation and also found that the phase difference jumped about 180°. Li et al. [50] studied the nonlinear characteristics of VIV at and successfully captured phase-switch, lock-in, and beat phenomena. Wang et al. [51] has demonstrated the importance higher harmonic flow forces and phase mechanisms related to relative velocity and has study the effects of the relative velocity of the cylinder’s oscillation with respect to the follow. Vortex formation modes been studied by 2D and 3D simulations before [6, 52, 53, 54, 55, 56]. The abovementioned research [6, 46, 47, 48, 49, 50, 52, 53, 54, 55, 56] highlighted typical behaviors in the relation between CF responses and lift and vortex shedding modes of the both elastically mounted cylinders and forced VIVs but did not clarify the science behind the law of the relationship between vortex shedding and phase difference, or how the vortex affects the phase difference. Despite numerous studies of typical behaviors of the VIV of an elastic cylinder, the underlying mechanisms governing typical behaviors such as phase difference remain to be elucidated. Han et al. [28] investigates the VIV of an elastically mounted cylinder at various frequency ratios. According to differences in the vortex shedding location, the vortex wake can be characterized by two kinds of mode, that is, the “first mode” and the “second mode”. The mechanisms behind the phases of the first mode and the second mode vortex wakes are investigated and it is found that the flow speed induced by a cylindrical transverse vibration and the position of a vortex release are the root causes of the phase difference between the lift coefficient and transverse displacement. The speeds caused by a cylinder vibration and a cylinder shed vortex are the reasons that the lift amplitude of an oscillatory cylinder is different from that of a fixed cylinder. For a CF VIV, when a cylinder sheds the vortex, in addition to producing a flow similar to that of a fixed cylinder with a velocity of
Schematic diagram of the flow field around a fixed cylinder [
Schematic diagram of the “first mode” flow field around a cylinder for CF VIV [
Schematic diagram of the “second mode” flow field around a cylinder for CF VIV [
The basic idea of the multi-strip method is to take a certain number of 2D slices of the riser in the axial direction to simulate the flow field and extract the load acting on the riser. Then, the load is applied to the riser to obtain the motion response of the riser, and the load is applied to the riser to obtain the movement response of the riser, which is carried out repeatedly, and finally to predict the VIV of the riser. This multi-strip method can effectively reduce the calculation time, and many scholars [57, 58, 59, 60, 61] compare the prediction data obtained by the multi-strip method with the experimental data, and the results are relatively consistent. Willden and Graham [59] used the multi-strip method to construct the quasi-three-dimensional riser model to simulate the VIV of riser in the transverse direction under shear flow and found that the fluid controlled the vibration frequency of the structure by influencing additional mass. Yamamoto et al. [57] established a quasi-three-dimensional CFD model, solved the hydrodynamic force of each section with the discrete vortex method, and calculated the vibration response of marine riser based on the Euler Bernoulli beam theory. The vibration response of the riser at different reduction velocities was calculated and compared with the test results. It was found that there was a vortex in the form of “2P” in the larger amplitude and a vortex in the form of “2S” in the smaller amplitude. Based on the theory of slicing method and the radial basis function dynamic mesh technology. Professor Wan [62, 63, 64, 65, 66] led the team to use OpenFOAM to solve the fluid field at each section and used the structural finite element method to simulate the motion response of the riser. The effects of various parameters (such as mass ratio, tip pretension, flow velocity and flow profile) on VIV of a riser were investigated. However, the VIV of a marine riser is a 3D problem in nature, and it is impossible to consider the influence of the flow along the axial direction by using the multi-strip method, and the description of the vibration mechanism of multi-modal coexistence is relatively vague. In addition, for the slicing method, it needs some interpolation algorithms to deal with the relationship between the slices, but this interpolation algorithm does not have a uniform standard [67, 68]. Hovor et al. [69] studied the three-dimensional effect of the wake of oscillating cylinder and the correlation of the flow force along the axial direction and proposed that the three-dimensional flow field characteristics of the vertical tube VIV are closely related to its structure amplitude, and the three-dimensional effect of the wake limited the further increase of the structure response amplitude.
In recent years, due to the improvement of computer hardware, several fully 3D numerical simulations of a marine riser VIV are generated. Constantinides et al. [67] used a finite element Navier-Stokes (NS) solver to study a high L/D riser model. This method overcame the shortcomings of the Q3D method and correctly estimated the 3D effect. The response amplitude of the numerical simulation was compared with experiment to verify the rationality of the algorithm and vortex shedding modes were briefly analyzed. Holmes et al. [68] used fully 3D CFD methods to simulate a straked riser VIV. The resulting solutions were compared with available experiment data on a 38 m long riser model based on RMS displacements. Xie et al. [70] used a finite-volume method to study the multi-mode VIV of a flexible circular cylinder. Huang et al. [71, 72] used a RANS method and an overlapping mesh technique to simulate the VIV of a riser with the length to diameter ratio of 482 in uniform flow and shear flow environments and compared numerical calculation results with the experiment to verify the accuracy of the calculation procedure. Bourguet et al. [73, 74, 75, 76] used direct numerical simulation of the 3D incompressible NS equations and a beam model to simulate the VIV of a cylindrical tensioned beam with the aspect ratio of 200 in linear and exponential shear flows at a Reynolds number equal to 330. Phasing mechanisms between the IL and CF, mono- and multi-frequency, and lock-in of VIV were explained.
In recent studies, many researches have investigated the VIV of marine risers but most of their research has been limited to 2D or rigid cylinder VIV. For the 3D flexible riser VIV, researchers have mostly adopted the 2.5D method. Only a few studies have adopted a bidirectional fluid-structure interaction method to simulate the VIV of the riser. In such studies, the displacement of the riser was solved using a mode superposition method or the Euler-Bernoulli bending beam equations. Most of these studies have concentrated on quantification of the vibration response. Nevertheless, the frequency characteristics of the vibration response and the universal rule of vortex shedding modes and trajectories in the spanwise direction have been less addressed, so further research is needed. Meanwhile, some studies have focused only on the VIV of a riser in linear and exponential shear flows at low Reynolds numbers, and further study is needed for the VIV of a riser in uniform flows at higher Reynolds numbers.
Studies on VIV in recent decades are often accompanied by the discovery of new phenomena and locked-in, jump, lower branch, upper branch, super upper branch, lower branch, and various wake vortex forms (such as 2P, 2T, P + S) are found in cylindrical VIV; in the study of 3D marine riser VIV, the phenomenon of traveling-standing wave interaction propagation, multi-modal vibration and high-order modal vibration was found. Scholars have been continuously exploring the conditions and internal mechanism of these new phenomena, but it is difficult to give a conclusion at present. The goal is to further understand the phenomenon of VIV and extract the internal logic relations of major factors affecting VIV, to establish a more reasonable prediction model to serve ocean engineering practice.
The prediction model of marine riser VIV still needs to be improved. Different from the numerical simulation based on CFD and FEM, these prediction models applied to practical engineering should be of high computational efficiency and can be easily applied to the structural design of marine riser. Perfect forecast model mainly from the following two aspects, that is, one is using simple parameters reflect the basic characteristics of VIV problem and special phenomenon of VIV (jumping, the response of each branch, etc.), and the selection of its value cannot rely too much on user’s personal experience, avoid parameters selection process cumbersome and lose operability. Another is building empirical models that can be validated on a broader scale. At present, although there are various models, and each of them can be verified well under certain conditions, there will be great differences in the calculation of back-to-back verification. No model has absolute advantage, and it is difficult for one model to match the results of multiple experiments.
With the continuous improvement of computer operation speed, numerical methods have been developed rapidly, and now have become one of the main research methods in parallel with theoretical analysis and tank test. The fluid-solid coupling numerical methods based on CFD and CSD are playing more and more important roles in the field of ocean engineering, especially in the design of offshore platforms and structural safety reliability analysis. The development of efficient large-scale parallel numerical analysis system will be an important direction to enhance the competitiveness in the field of ocean engineering in the future.
The 3D numerical simulation of the VIV of marine riser requires a hydrodynamic computational program and a structural mechanical computational program. In the coupling interface, fluid dynamic data and structural displacement data are exchanged, which involves grid data mapping, interpolation and fluid mesh reconstruction of fluid and solid media, resulting in the reduction of precision. In addition, the computing technology also involves some key technical problems, such as efficient interactive use between different solvers, economic and practical parallel algorithm and parallel programming, etc., and exploring more effective algorithms to further improve precision and efficiency is still one of the focuses of recent research. With the increase of the length-diameter ratio of marine riser and the increase of Reynolds number (the actual Reynolds number of marine engineering is mostly within the range of 105–106), the above problems become more difficult to solve. Research on circular VIV within the range of high Reynolds number is still rare, so it is necessary to conduct research on VIV under the condition of high Reynolds number, further enrich the research results, explore new fluid-solid coupling phenomena and theories, and lay a theoretical foundation for the conceptual design of marine engineering riser.
This chapter summarizes the research status of various numerical calculation methods, including empirical model and CFD numerical calculation. In the aspect of experience model, this chapter briefs the development process of experience model and the deficiency of current experience model is proposed. In the aspect of 2D numerical simulation, the progress of 2D numerical simulation of VIV is summarized combining the author’s own research work on the two hot phenomena of super upper branch and phase jump. The development process of the multi-strip method for 3D marine riser VIV simulation is introduced in the aspect of 2.5D numerical simulation. In the aspect of 3D numerical simulation, numerical simulation of 3D marine riser VIV is analyzed with the limitations of current 3D marine riser research. At the end of the chapter, the future research direction is proposed, including the nonlinear mechanism of VIV, prediction models, and CFD and CSD fluid-solid interaction models.
This study was supported by the Guangxi natural science foundation (No. 2018GXNSFBA281138), the National Natural Science Foundation of China (No. 51809144), the Guangxi Major science and technology projects (No. AA17292007), a middle-aged and young teachers’ basic ability promotion project of Guangxi Zhuang Autonomous Region of China (2019KY0443), Qinzhou College Scientific Research Project (2016PY-SJ08), Key subject of Guangxi (Naval Architecture and Ocean Engineering of Qinzhou University) Foundation, and Haiou Talent Plan of Qinzhou City.
No conflict of interest declared.
Ay | the amplitude of the transverse vibration |
D | the cylinder diameter |
U | the inlet velocity |
m∗=m/md | ratio of oscillating mass over displaced mass |
ma=ρπD2/4 | added mass in still water |
St=f0D/U | Strouhal number in still water |
Re=UD/ν | Reynolds number |
ν | kinematic viscosity coefficient |
U∗=U/fnD | reduced velocity in water |
fn=12πkm+ma | natural frequency of elastic cylinder in still water |
fnx | natural frequency of elastic cylinder of x direction in still water |
fny | natural frequency of elastic cylinder of y direction in still water |
Previous investigations (e.g., [1, 2]) have attempted to provide a better understanding and awareness vis-à-vis the two types of hypotheses that exist in all fields of empirical science: universal-deterministic (UD) and probabilistic. In particular, those papers emphasize the potential problems of not acknowledging the theoretical/empirical differences between these two types of scientific propositions. Continuing with this line of research, our paper deals with some objections that have been made by experts in the operations management (OM) field1. More specifically, our paper discusses why those criticisms are not justified. This article strengthens the argument about the importance of acknowledging the distinct characteristics that UD and probabilistic hypotheses possess. This topic is important, not only in operations management research, but in all areas of empirical science.
In sections 2, 3, and 4, we present the aforementioned criticisms and explain why those objections lack justification. In Section 5, we further explore (based on Popperian logic and methodology) how falsified hypotheses can still be of practical use. Section 6 offers some concluding remarks.
There is no question that variability in the measurement of individual observations is an important issue in the empirical sciences. Nevertheless, it is not accurate to say that measurement variability transforms a UD hypothesis into a probabilistic one. These are two separate issues: 1) the problems with the measurement of empirical evidence (e.g., individual observations) when testing a hypothesis of interest, and 2) the logical form and implications of UD hypotheses.
Popper (e.g., [7], p. 63) acknowledges the potential problems that exist with respect to measurement variability. His recommendation is that there should be “methodological rules” by which decisions regarding empirical evidence in support of or against a given hypothesis may be agreed upon: “… Inter-subjectively testable experiments are either to be accepted, or to be rejected in the light of counter-experiments.” Or as Dienes ([8], p. 20, his italics) puts it,
To illustrate Popper’s point, we recall the story of the experiments and events that corroborated Einstein’s general theory of relativity. According to Folsing, ([9], p. 443),
This famous episode in the history of science shows that irrespective of the variability/errors that sometimes are inevitable when measuring empirical evidence, scientists can still develop methodological rules/agreements in order to judge whether the predictions/implications of a UD hypothesis have been corroborated or refuted. Put differently, the variability in the measurement of empirical evidence does not turn a UD hypothesis (e.g., Einstein’s) into a probabilistic one.
We now offer a more recent example. Overbye [10] reported that in September of 2011, a group of scientists announced that they had measured a batch of subatomic particles (neutrinos) traveling faster than the speed of light. This appeared to falsify the UD law that negates that specific occurrence (“no object can travel faster than the speed of light”). However, Overbye then quoted a scientist as saying that “[T]he evidence is beginning to point toward the (results showing falsifying evidence of the UD law) being an artifact of the measurement” (see also [11] for more reports about the same episode).
The neutrinos story was very interesting to follow because the whole process – from the initial claims of falsification to the conclusion that errors had been made during the experiments – was consistent with the logic and methodology that Popper proposed in order to test a UD law. It also serves to illustrate once more that regardless of the different potential difficulties that can be present when testing a UD hypothesis, scientists can still come to the conclusion (based on methodological rules/conventions) that a given UD proposition has been refuted or corroborated. This helps us to affirm that the different difficulties that might appear when testing a UD hypothesis do not turn it into a probabilistic one.
These criticisms arguably reflect the prevalent thinking among scientists that are familiar with the frequentist approach to probability and statistical hypothesis testing2. For the sake of argument, we will assume that this approach is an adequate way to apply Popperian falsificationism when testing a probabilistic hypothesis3. In this approach, researchers usually have to formulate a null hypothesis (Ho) and an alternative hypothesis (H1). We will use these assumptions and conventions to explain one of the theoretical/empirical differences between UD and probabilistic hypotheses.
We first discuss a situation where researchers are interested in testing whether a variable “A” (the cause) has an effect on variable “B”. We model this relationship using the usual principles and assumptions of standard linear regression analysis. We state Ho as a general proposition: “A has no noticeable effect on B” (e.g., Ho: β1 = 0). We also establish H1 as “A has a noticeable effect (e.g., “statistically significant”) on B” (e.g., β1 ≠ 0). Let us also suppose that two different investigations are performed: one to test a probabilistic relationship between A and B, and the other one to test its UD version. To be clear that we are dealing with two different and separate situations, we will rename the variables as
Evidence supporting a probabilistic relationship between
Evidence supporting a UD relationship between Ad and Bd.
These figures show evidence supporting the alternative hypothesis (e.g., H1: “A has a noticeable and positive effect on B”) in both its probabilistic and UD forms. Based on this, the assertion that there are no practical differences between these two types of hypotheses would appear to be true. Put differently, since Figures 1 and 2 support the idea that Ho (“A has no noticeable effect on B”) in its probabilistic and UD forms has been “practically falsified” and “falsified,” respectively, it does seem as if arguing that UD and probabilistic hypotheses are different in nature is indeed a red herring.
We now proceed to explain that, in spite of what was discussed previously, there are clear theoretical/empirical differences between UD and probabilistic hypotheses. To accomplish our objective, we again model a causal relationship between two different variables: C (“the cause”) and D (“the effect”). We make the same assumptions as before, with only one difference: we now suppose that there is prior corroborating evidence showing a noticeable and positive effect of C on D. We state the probabilistic version of this relationship as “
Evidence that “practically falsifies” a probabilistic relationship between
Evidence that falsifies (logically and strictly) a UD relationship between
These illustrations show one of the theoretical/empirical differences between UD and probabilistic hypotheses. Figure 3 shows evidence that the probabilistic relationship between
While it is true that in both cases there appears to be undermining/falsifying evidence against Ho
To complement the current discussion, we now offer an example of a relationship where the dependent and independent variables can be present or absent. To avoid repetition, now we will only model the situation where Ho states a prior noticeable effect of E (the cause) on F (the effect). The probabilistic form of this relationship can be phrased along the lines of “if E occurs/is present, then F is more likely to occur/be present than not.” Its UD form can be stated as “If E occurs/is present, then F will always occur/be present.” Once more we utilize
Let us suppose that we collect two different samples to test the two distinct hypotheses. In the case of the probabilistic relationship, let us assume that we found two cases where
Evidence that practically falsifies a probabilistic relationship between Ep and Fp.
In the case of a UD hypothesis, let us suppose that we found four cases where
Similar to the scenario disused before, it can be seen again that when researchers find evidence that “practically falsifies” a hypothesis stating that “if
Evidence that falsifies (logically and strictly) a UD relationship between
The previous discussions show a clear difference between UD and probabilistic hypotheses: a “practically falsified” probabilistic hypothesis (
The Cambridge Dictionary online4 defines the word “interesting” as:
It could be validly argued that a UD relationship (e.g., something that always occurs) is far more interesting that something that takes place, for example, in most cases (e.g., a probabilistic relationship). Nonetheless, irrespective of why a researcher may deem a causal relationship interesting, we think that all scientists should be knowledgeable about the theoretical/empirical differences between UD and probabilistic hypotheses. This is important in order to avoid inaccuracies/omissions when hypothesis-testing and also when offering advice about research methodology (see [2] for a more detailed discussion about these issues in OM research).
Furthermore, while it is clear that the OM field (and arguably most of Social Sciences5) has been dominated by what could be called as “significance testing” [13], recently some scientists have also attempted to emphasize the importance and utility of UD hypotheses, for example, in the Business/Operations Management field [1, 14]. Likewise, Dienes ([8], p. 26, his italics) affirms that.
Therefore, if UD hypotheses are to become more prominent in the Social Sciences, then it follows that scientists should be aware of their differences vis-à-vis probabilistic hypotheses, regardless of whether scientists (in their subjective views) think them interesting or not.
In Section 3, we explained that when a probabilistic hypothesis has been “practically falsified,” researchers should be inclined to conclude that there is no evidence at all of a causal relationship between an independent and a dependent variable. We also explained that when a UD hypothesis has been logically and strictly falsified, it could still be of practical use, as a noticeable causal relationship between two variables could still be identified (see Figures 4 and 6).
It is not possible to be certain regarding the reasons that explain why expert researchers (see footnote 1) still opine that the differences between UD and probabilistic hypotheses are just a red herring and unimportant. Nevertheless, we think that a contributing factor might be the lack of awareness about the fact that falsified hypotheses can still be of practical utility. It would appear as if researchers tend to equate the terms “falsified/false” with “useless,” “meaningless” or “pointless.” To support our contention that falsified hypotheses can still be of use, we quote Popper ([15], p. 74):
… false theories often serve well enough: most formulae used in engineering or navigation are known to be false, although they may be excellent approximations and easy to handle; and they are used with confidence by people who know them to be false.
Even though Newtonian physics have been “recognized as literally false” ([8], p. 5), “… scientists needed nothing more than Newton’s equations to plot the course of the rocket that landed men on the moon” [16].
More specifically, in the OM field, the influential strategic trade-offs model [17] was put forward as a UD theory [2]. Even if empirical evidence were to falsify – logically and strictly – this proposition in the future, it would be difficult for researchers to affirm that Skinner’s core argument (“
The fact that strictly and logically false/falsified (UD) hypotheses can still be of practical/empirical use should serve to strengthen our argument about the importance of acknowledging the differences that exist between UD and probabilistic hypotheses in empirical science.
Investigations that deal directly with the topics of universal-deterministic and probabilistic hypotheses are not common in business management research in general, and operations management science in particular. Our hope is that this paper can contribute to a better understanding of the theoretical/empirical differences that exist between these two types of hypotheses.
Very few papers in the operations management (OM) field have taken the themes of universal-deterministic (UD) and probabilistic hypotheses as their main topics of investigation and discussion. Our investigation continues a recent line of research that focuses on a better understanding of these critical issues. Specifically, we attempt to respond to some pointed criticisms that experts in the field have made when the topic UD and probabilistic hypotheses have emerged in academic settings/discussions. A detailed analysis of those criticisms shows that they lack merit, thereby reinforcing our argument that it is most important to distinguish between the two types of scientific hypotheses in order to advance in the rigor of OM theoretical and empirical research. Ideas for future research are outlined.
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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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It is a cofactor for enzymes involved in regulating photosynthesis, hormone biosynthesis, and regenerating other antioxidants; which also regulates cell division and growth, is involved in signal transduction, and has roles in several physiological processes, such as immune stimulation, synthesis of collagen, hormones, neurotransmitters, and iron absorption, has also roles in detoxifying the body of heavy metals. Severe deficiency of vitamin C causes scurvy, whereas limited vitamin C intake causes symptoms, such as increased susceptibility to infections, loosening of teeth, dryness of the mouth and eyes, loss of hair, dry itchy skin, fatigue, and insomnia. In contrast, vitamin C can also act as a prooxidant, especially in the presence of transition metals, such as iron and copper, starting different hazardous radical reactions. Vitamin C can both act as a strong, efficient, and cheap antioxidant agent and, at the same time, behave as a radical promoter. Further investigations are needed to illuminate the dual roles of vitamin C",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Fadime Eryılmaz Pehlivan",authors:[{id:"200567",title:"Dr.",name:"Fadime",middleName:null,surname:"Eryılmaz Pehlivan",slug:"fadime-eryilmaz-pehlivan",fullName:"Fadime Eryılmaz Pehlivan"}]},{id:"56440",doi:"10.5772/intechopen.70162",title:"Vitamin C: Sources, Functions, Sensing and Analysis",slug:"vitamin-c-sources-functions-sensing-and-analysis",totalDownloads:6423,totalCrossrefCites:15,totalDimensionsCites:28,abstract:"Vitamin C is a water-soluble compound found in living organisms. It is an essential nutrient for various metabolism in our body and also serves as a reagent for the preparation of many materials in the pharmaceutical and food industry. In this perspective, this chapter can develop interest and curiosity among all practicing scientists and technologists by expounding the details of its sources, chemistry, multifunctional properties and applications.",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Sudha J. Devaki and Reshma Lali Raveendran",authors:[{id:"187911",title:"Associate Prof.",name:"Sudha",middleName:null,surname:"J Devaki",slug:"sudha-j-devaki",fullName:"Sudha J Devaki"},{id:"204937",title:"Mrs.",name:"Reshma",middleName:null,surname:"Laly Ravindran",slug:"reshma-laly-ravindran",fullName:"Reshma Laly Ravindran"}]},{id:"50921",doi:"10.5772/63712",title:"Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet",slug:"menaquinones-bacteria-and-foods-vitamin-k2-in-the-diet",totalDownloads:3315,totalCrossrefCites:10,totalDimensionsCites:21,abstract:"Vitamin K2 is a collection of isoprenologues that mostly originate from bacterial synthesis, also called menaquinones (MKs). Multiple bacterial species used as starter cultures for food fermentation are known to synthesize MK. Therefore, fermented food is the best source of vitamin K2. In the Western diet, dairy products are one of the best known and most commonly consumed group of fermented products.",book:{id:"5169",slug:"vitamin-k2-vital-for-health-and-wellbeing",title:"Vitamin K2",fullTitle:"Vitamin K2 - Vital for Health and Wellbeing"},signatures:"Barbara Walther and Magali Chollet",authors:[{id:"184784",title:"Dr.",name:"Barbara",middleName:null,surname:"Walther",slug:"barbara-walther",fullName:"Barbara Walther"},{id:"188194",title:"Mrs.",name:"Magali",middleName:null,surname:"Chollet",slug:"magali-chollet",fullName:"Magali Chollet"}]},{id:"66098",doi:"10.5772/intechopen.84445",title:"Golden Rice: To Combat Vitamin A Deficiency for Public Health",slug:"golden-rice-to-combat-vitamin-a-deficiency-for-public-health",totalDownloads:3377,totalCrossrefCites:12,totalDimensionsCites:17,abstract:"Vitamin A deficiency (VAD) has been recognised as a significant public health problem continuously for more than 30 years, despite current interventions. The problem is particularly severe in populations where rice is the staple food and diversity of diet is limited, as white rice contains no micronutrients. Golden Rice is a public-sector product designed as an additional intervention for VAD. There will be no charge for the nutritional trait, which has been donated by its inventors for use in public-sector rice varieties to assist the resource poor, and no limitations on what small farmers can do with the crop—saving and replanting seed, selling seed and selling grain are all possible. Because Golden Rice had to be created by introducing two new genes—one from maize and the other from a very commonly ingested soil bacterium—it has taken a long time to get from the laboratory to the field. Now it has been formally registered as safe as food, feed, or in processed form by four industrialised counties, and applications are pending in developing countries. The data are summarised here, and criticisms addressed, for a public health professional audience: is it needed, will it work, is it safe and is it economic? Adoption of Golden Rice, the next step after in-country registration, requires strategic and tactical cooperation across professions, non-governmental organisations (NGOs) and government departments often not used to working together. Public health professionals need to play a prominent role.",book:{id:"7978",slug:"vitamin-a",title:"Vitamin A",fullTitle:"Vitamin A"},signatures:"Adrian Dubock",authors:[{id:"273220",title:"Ph.D.",name:"Adrian",middleName:null,surname:"Dubock",slug:"adrian-dubock",fullName:"Adrian Dubock"}]},{id:"62836",doi:"10.5772/intechopen.79350",title:"The Role of Thiamine in Plants and Current Perspectives in Crop Improvement",slug:"the-role-of-thiamine-in-plants-and-current-perspectives-in-crop-improvement",totalDownloads:1564,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"Current research is focusing on selecting potential genes that can alleviate stress and produce disease-tolerant crop variety. The novel paradigm is to investigate the potential of thiamine as a crop protection molecule in plants. Thiamine or vitamin B1 is important for primary metabolism for all living organisms. The active form, thiamine pyrophosphate (TPP), is a cofactor for the enzymes involved in the synthesis of amino acids, tricarboxylic acid cycle and pentose phosphate pathway. Recently, thiamine is shown to have a role in the processes underlying protection of plants against biotic and abiotic stresses. The aim of this chapter is to review the role of thiamine in plant growth and disease protection and also to highlight that TPP and its intermediates are involved in management of stress. The perspectives on its potential for manipulating the biosynthesis pathway in crop improvement will also be discussed.",book:{id:"6709",slug:"b-group-vitamins-current-uses-and-perspectives",title:"B Group Vitamins",fullTitle:"B Group Vitamins - Current Uses and Perspectives"},signatures:"Atiqah Subki, Aisamuddin Ardi Zainal Abidin and Zetty Norhana\nBalia Yusof",authors:[{id:"240031",title:"Dr.",name:"Zetty-Norhana Balia",middleName:null,surname:"Yusof",slug:"zetty-norhana-balia-yusof",fullName:"Zetty-Norhana Balia Yusof"},{id:"261167",title:"Mr.",name:"Aisamuddin Ardi",middleName:null,surname:"Zainal Abidin",slug:"aisamuddin-ardi-zainal-abidin",fullName:"Aisamuddin Ardi Zainal Abidin"},{id:"261169",title:"Ms.",name:"Atiqah",middleName:null,surname:"Subki",slug:"atiqah-subki",fullName:"Atiqah Subki"}]}],mostDownloadedChaptersLast30Days:[{id:"56440",title:"Vitamin C: Sources, Functions, Sensing and Analysis",slug:"vitamin-c-sources-functions-sensing-and-analysis",totalDownloads:6423,totalCrossrefCites:15,totalDimensionsCites:28,abstract:"Vitamin C is a water-soluble compound found in living organisms. It is an essential nutrient for various metabolism in our body and also serves as a reagent for the preparation of many materials in the pharmaceutical and food industry. In this perspective, this chapter can develop interest and curiosity among all practicing scientists and technologists by expounding the details of its sources, chemistry, multifunctional properties and applications.",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Sudha J. Devaki and Reshma Lali Raveendran",authors:[{id:"187911",title:"Associate Prof.",name:"Sudha",middleName:null,surname:"J Devaki",slug:"sudha-j-devaki",fullName:"Sudha J Devaki"},{id:"204937",title:"Mrs.",name:"Reshma",middleName:null,surname:"Laly Ravindran",slug:"reshma-laly-ravindran",fullName:"Reshma Laly Ravindran"}]},{id:"56013",title:"Vitamin C: An Antioxidant Agent",slug:"vitamin-c-an-antioxidant-agent",totalDownloads:7808,totalCrossrefCites:26,totalDimensionsCites:59,abstract:"Vitamin C or ascorbic acid (AsA) is a naturally occurring organic compound with antioxidant properties, found in both animals and plants. It functions as a redox buffer which can reduce, and thereby neutralize, reactive oxygen species. It is a cofactor for enzymes involved in regulating photosynthesis, hormone biosynthesis, and regenerating other antioxidants; which also regulates cell division and growth, is involved in signal transduction, and has roles in several physiological processes, such as immune stimulation, synthesis of collagen, hormones, neurotransmitters, and iron absorption, has also roles in detoxifying the body of heavy metals. Severe deficiency of vitamin C causes scurvy, whereas limited vitamin C intake causes symptoms, such as increased susceptibility to infections, loosening of teeth, dryness of the mouth and eyes, loss of hair, dry itchy skin, fatigue, and insomnia. In contrast, vitamin C can also act as a prooxidant, especially in the presence of transition metals, such as iron and copper, starting different hazardous radical reactions. Vitamin C can both act as a strong, efficient, and cheap antioxidant agent and, at the same time, behave as a radical promoter. Further investigations are needed to illuminate the dual roles of vitamin C",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Fadime Eryılmaz Pehlivan",authors:[{id:"200567",title:"Dr.",name:"Fadime",middleName:null,surname:"Eryılmaz Pehlivan",slug:"fadime-eryilmaz-pehlivan",fullName:"Fadime Eryılmaz Pehlivan"}]},{id:"69402",title:"Vitamin D Deficiency and Diabetes Mellitus",slug:"vitamin-d-deficiency-and-diabetes-mellitus",totalDownloads:1600,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Vitamin D (VD) is a molecule that can be synthesized directly in the humans’ body or enter the organism with food in the form of inactive precursors. To exert its biological action, VD undergoes two-stage hydroxylation (at the 25th and 1st position) catalyzed by cytochromes P450, the presence of which has already been shown in almost all tissues of the human body. The product of hydroxylation is hormone-active form of vitamin D–1,25(OH)2D. 1,25(OH)2D binds to specific vitamin D receptor (VDR) and regulates the expression of genes involved in bone remodeling (classical function) and genes that control immune response, hormone secretion, cell proliferation, and differentiation (nonclassical functions). VD deficiency is prevalent around the globe and may be one of the key factors for diabetes development. The direct association between vitamin D deficiency and type 1 (T1D) and type 2 (T2D) diabetes has been proven. Detection of VDR in pancreas and adipose tissue, skeletal muscles, and immune cells allowed implying the antidiabetic role of vitamin D by enhancing insulin synthesis and exocytosis, increasing the expression of the insulin receptor, and modulating immune cells’ functions. This chapter summarizes data about relationship between VD insufficiency/deficiency and development of T1D and T2D, and their complications.",book:{id:"7038",slug:"vitamin-d-deficiency",title:"Vitamin D Deficiency",fullTitle:"Vitamin D Deficiency"},signatures:"Ihor Shymanskyi, Olha Lisakovska, Anna Mazanova and Mykola Veliky",authors:null},{id:"76108",title:"Vitamin D Metabolism",slug:"vitamin-d-metabolism",totalDownloads:493,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Vitamin D plays an important role in bone metabolism. Vitamin D is a group of biologically inactive, fat-soluble prohormones that exist in two major forms: ergocalciferol (vitamin D2) produced by plants in response to ultraviolet irradiation and cholecalciferol (vitamin D3) derived from animal tissues or 7-dehydrocholesterol in human skin by the action of ultraviolet rays present in sunlight. Vitamin D, which is biologically inactive, needs two-step hydroxylation for activation. All of these steps are of crucial for Vitamin D to show its effect properly. In this section, we will present vitamin D synthesis and its action steps in detail.",book:{id:"10631",slug:"vitamin-d",title:"Vitamin D",fullTitle:"Vitamin D"},signatures:"Sezer Acar and Behzat Özkan",authors:[{id:"29878",title:"Dr.",name:"Behzat",middleName:null,surname:"Özkan",slug:"behzat-ozkan",fullName:"Behzat Özkan"},{id:"348287",title:"Dr.",name:"Sezer",middleName:null,surname:"Acar",slug:"sezer-acar",fullName:"Sezer Acar"}]},{id:"50754",title:"Medicinal Chemistry of Vitamin K Derivatives and Metabolites",slug:"medicinal-chemistry-of-vitamin-k-derivatives-and-metabolites",totalDownloads:1915,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Vitamin K acts as a cofactor for γ‐glutamyl carboxylase. Recently, various biological activities of vitamin K have been reported. Anti‐proliferative activities of vitamin K, especially in vitamin K3, are well known. In addition, various physiological and pharmacological functions of vitamin K2, such as transcription modulators as nuclear steroid and xenobiotic receptor (SXR) ligands and anti‐inflammatory effects, have been revealed in the past decade. Characterization of vitamin K metabolites is also important for clinical application of vitamin K and its derivatives. In this chapter, recent progress on the medicinal chemistry of vitamin K derivatives and metabolites is discussed.",book:{id:"5169",slug:"vitamin-k2-vital-for-health-and-wellbeing",title:"Vitamin K2",fullTitle:"Vitamin K2 - Vital for Health and Wellbeing"},signatures:"Shinya Fujii and Hiroyuki Kagechika",authors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika"},{id:"180529",title:"Dr.",name:"Shinya",middleName:null,surname:"Fujii",slug:"shinya-fujii",fullName:"Shinya Fujii"}]}],onlineFirstChaptersFilter:{topicId:"42",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!0,editor:{id:"205604",title:"Dr.",name:"Tomas",middleName:null,surname:"Jarzembowski",slug:"tomas-jarzembowski",fullName:"Tomas Jarzembowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKriQAG/Profile_Picture_2022-06-16T11:01:31.jpg",biography:"Tomasz Jarzembowski was born in 1968 in Gdansk, Poland. He obtained his Ph.D. degree in 2000 from the Medical University of Gdańsk (UG). After specialization in clinical microbiology in 2003, he started studying biofilm formation and antibiotic resistance at the single-cell level. In 2015, he obtained his D.Sc. degree. His later study in cooperation with experts in nephrology and immunology resulted in the designation of the new diagnostic method of UTI, patented in 2017. He is currently working at the Department of Microbiology, Medical University of Gdańsk (GUMed), Poland. Since many years, he is a member of steering committee of Gdańsk branch of Polish Society of Microbiologists, a member of ESCMID. He is also a reviewer and a member of editorial boards of a number of international journals.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorTwo:{id:"484980",title:"Dr.",name:"Katarzyna",middleName:null,surname:"Garbacz",slug:"katarzyna-garbacz",fullName:"Katarzyna Garbacz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003St8TAQAZ/Profile_Picture_2022-07-07T09:45:16.jpg",biography:"Katarzyna Maria Garbacz, MD, is an Associate Professor at the Medical University of Gdańsk, Poland and she is head of the Department of Oral Microbiology of the Medical University of Gdańsk. She has published more than 50 scientific publications in peer-reviewed journals. She has been a project leader funded by the National Science Centre of Poland. Prof. Garbacz is a microbiologist working on applied and fundamental questions in microbial epidemiology and pathogenesis. Her research interest is in antibiotic resistance, host-pathogen interaction, and therapeutics development for staphylococcal pathogens, mainly Staphylococcus aureus, which causes hospital-acquired infections. Currently, her research is mostly focused on the study of oral pathogens, particularly Staphylococcus spp.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:19,paginationItems:[{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82827",title:"Epidemiology and Control of Schistosomiasis",doi:"10.5772/intechopen.105170",signatures:"Célestin Kyambikwa Bisangamo",slug:"epidemiology-and-control-of-schistosomiasis",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82667",title:"Perspective Chapter: Analysis of SARS-CoV-2 Indirect Spreading Routes and Possible Countermeasures",doi:"10.5772/intechopen.105914",signatures:"Cesare Saccani, Marco Pellegrini and Alessandro Guzzini",slug:"perspective-chapter-analysis-of-sars-cov-2-indirect-spreading-routes-and-possible-countermeasures",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},overviewPagePublishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. 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The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. 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She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"322007",title:"Dr.",name:"Maria Elizbeth",middleName:null,surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",country:{name:"Mexico"}}},{id:"337443",title:"Dr.",name:"Juan",middleName:null,surname:"A. 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\r\n\tGlobally, the ecological footprint is growing at a faster rate than GDP. This phenomenon has been studied by scientists for many years. However, clear strategies and actions are needed now more than ever. Every day, humanity, from individuals to businesses (public and private) and governments, are called to change their mindset in order to pursue a virtuous combination for sustainable development. Reasoning in a sustainable way entails, first and foremost, managing the available resources efficiently and strategically, whether they are natural, financial, human or relational. In this way, value is generated by contributing to the growth, improvement and socio-economic development of the communities and of all the players that make up its value chain. In the coming decades, we will need to be able to transition from a society in which economic well-being and health are measured by the growth of production and material consumption, to a society in which we live better while consuming less. In this context, digitization has the potential to disrupt processes, with significant implications for the environment and sustainable development. There are numerous challenges associated with sustainability and digitization, the need to consider new business models capable of extracting value, data ownership and sharing and integration, as well as collaboration across the entire supply chain of a product. In order to generate value, effectively developing a complex system based on sustainability principles is a challenge that requires a deep commitment to both technological factors, such as data and platforms, and human dimensions, such as trust and collaboration. Regular study, research and implementation must be part of the road to sustainable solutions. Consequently, this topic will analyze growth models and techniques aimed at achieving intergenerational equity in terms of economic, social and environmental well-being. It will also cover various subjects, including risk assessment in the context of sustainable economy and a just society.
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