Showing a comparison of some important properties of solders and sinter materials used for die attach.
\r\n\tThis book will aim to survey the most recent diagnostic techniques as well as the most promising therapeutic options we can count on to deal with optic nerve disorders. The audience of the book is quite wide and it aims at being the main entry to this fascinating topic for students, clinicians, and researchers.
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Ferreri",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11704.jpg",keywords:"Toxic Neuropathy, Ethambutol, Methanol, Leber Neuropathy, Congenital Anomalies, Coloboma, Optic Disc Excavation, Systemic Anomalies, Optic Disc Swelling, Anterior ION, Posterior ION, ION Variants",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 25th 2022",dateEndSecondStepPublish:"June 2nd 2022",dateEndThirdStepPublish:"August 1st 2022",dateEndFourthStepPublish:"October 20th 2022",dateEndFifthStepPublish:"December 19th 2022",remainingDaysToSecondStep:"12 days",secondStepPassed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Prof. Felicia M. Ferreri graduated summa cum laude from the University of Messina, Italy in 1998. She served as co-investigator for many national and international clinical trials. 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All semiconductor devices need packaging of some sort, whether they are the integrated circuits of a computer’s central processing unit, an amplifier, diode, transistor or any other kind of device. This chapter focuses on power modules: a subsection of the field of semiconductor packaging. A power module normally contains several power electronics devices such as MOSFETs or IGBTs, diodes, and often the associated passive components like gate resistors and DC link capacitors. The package provides a mechanical interface with the rest of the system, since most semiconductor components produce heat that must be managed in order to keep the device below its maximum allowable junction temperate (Tjmax), the package is almost always mechanically connected to a heatsink. The packaging is also the primary thermal interface between the heat-generating devices and the heat sink. The operating temperature of the devices defines their performance and long-term reliability, if devices operate at higher temperatures their reliability will decrease exponentially as temperature increases [1]. As a result, the thermal interface provided by the packaging is crucially important, and many of the properties of the processes and materials are optimized to provide the best possible heat sink with the lowest achievable thermo-mechanical stress. Electrical interfaces between the devices and the system are also features of the package, with signal pins and power terminals being internally connected to the devices, and emerging through the packaging to allow external connections. Depending on the design, it is also common for electrical insulation to be a feature of the package, normally to ensure that the high-voltage part of the circuit inside is suitably isolated from the heatsink to which the package is attached. The outer surface of the package must also meet the requirements of creepage and clearance to ensure that the terminals are properly insulated from each other. The packaging also provides environmental protection for the modules to some degree. The simplest arrangements have a plastic housing filled with a potting compound, normally a silicone gel. The plastic case makes the module a robust component which can easily be handled during testing, installation, and operation while protecting the devices inside. The case and potting provide protection from dirt, contamination and foreign objects which could damage them or their interconnections. The package can provide reasonable protection from liquid water, but most packages do not provide thorough protection from water vapor. For special applications such as some aerospace systems, hermetically sealed packages are required to provide complete isolation from the environment.
\nA simplified diagram of a typical power electronics module is shown in Figure 1 which has the main design elements outlined above. There is a broad range of shapes and sizes of power modules, but the structure of many of the most commercially successful ones can be described as having similar construction to this. The semiconductor devices are attached, normally using solder, to a ceramic tile metallized with copper on each side. The tile, or substrate, provides a thermal path to extract heat from the device and has a circuit outline etched into the top to provide.
\nA simplified diagram of conventional power module packaging structure. Key to structure is the insulating ceramic tile which is soldered to a base plate. The semiconductors are soldered to the topside of the tile along with the power and signal terminals. The topside interconnection to the devices is achieved with wire bonding. The structure is then encapsulated in silicone gel and a plastic housing.
Isolation between contact pads for the various terminals of the device: anode and cathode in the case of a diode; emitter, gate and collector in the case of an IGBT; or gate, drain and source in the case of a MOSFET for example. Connections between these pads and the device are made using wirebonds, aluminum being a widely used metal in power electronics which is compatible with the aluminum surface of the device. With this combination of soldering and wirebonding, the device is connected to the package, and these connections are some of the most crucial for ensuring the long-term reliability of the entire package under real-world conditions [2]. The entire substrate is then soldered to the base plate, providing a thermal path from the device to the outside world. In many packages, multiple substrate tiles are soldered into one module. Terminals also need to be connected to the contact pads on the substrate tile to allow current flow into and out of the package, and auxiliary signal pins are connected for the device gates and other connections needed to control the devices. The entire arrangement is then surrounded by a plastic case and potted with dielectric gel to provide some protection and electrical insulation (Figure 2).
\nAn example of a three-phase power module with one SiC MOSFET per switch, negative temperature coefficient resistor for temperature sensing, and a DC link capacitor on each substrate. The package concept is similar to that shown in
Power module packages based on the principles shown in Figure 1 have been successful for decades but are not capable of exploiting the benefits of WBG devices such as higher junction temperatures and faster switching speeds. Every part of the package needs to be reconsidered if it is to become a high-performance part suitable for housing WBG semiconductors: the backside die attach material must be able to operate reliably for years at junction temperatures over 200°C; the topside attachment must be suitable for high power density and high reliability. The ceramic substrate and the base plate must have excellent thermal conductivity to keep the devices as cool as possible. The current density of SiC devices is higher than Si which is an advantage for reducing the volume of components, but it also makes it more difficult to cool them. The encapsulating gel must be able to sustain high temperatures without degrading especially since they are normally in intimate contact with the devices themselves, and therefore will be subject to some of the highest temperatures in the package. Further from the junction, temperatures will be lower but the capabilities of materials still need to improve, including the plastic housings, and glue used to connect the housing to the baseplate.
\nThese shortcomings in packaging technology have been recognized and described thoroughly for example in [3], and Section 2 presents a summary of some of the solutions that have been investigated.
\nSiC has a higher thermal conductivity than Si which is one of the properties that makes it an excellent material for power electronics devices. To take advantage of this, all the other materials in the module must have compatible high performance. Alumina or Al2O3 is the most widely used ceramic used for insulating substrates in power modules primarily due to its low cost and large numbers of suppliers across the world. The properties of Al2O3 are not ideal, having a relatively large thermal impedance and high coefficient of thermal expansion. AlN is commonly used in modules where higher reliability and lower thermal impedance are more important requirements, in applications such as rail traction and renewable energy, where system failures can be costly in terms of maintenance and operational losses. AlN has a thermal conductivity around six times greater than Al2O3, and CTE around half as much, making it a much more efficient heat sink which is a better thermal match to the semiconductor devices and therefore reduces thermomechanical stress, which is the main cause of fatigue and wear-out failure in power electronics modules. Silicon nitride, Si3N4, is being increasingly used because it has an even lower CTE than AlN and high mechanical strength [4]. The bond between the ceramic material and the metal layer of the substrate is a common wear-out failure mode caused by long time-constant (minutes and hours rather than seconds) temperature cycling of the module. Therefore, the reliability of the overall system is dependent on the reliability of the substrate material, and improving substrates is an intense area of R&D for the manufacturers. Active metal brazing for bonding the metallization to the ceramic has shown to be more reliable to peeling off then direct copper bonding (DBC), and also aluminum direct bonding (DBA) has been shown to excellent reliability. For these reasons, Si3N4 is likely to be an ideal substrate candidate material for WBG devices. Conventionally substrates have been formed of a single layer of ceramic with metallization on either side, but double layer ceramics are becoming more common for WBG applications: Two ceramic layers are bonded together with a metallization layer between them, with metallization on the top and bottom sides also, giving an overall sandwich structure of three layers of metal and two ceramic [5]. Typically, the top and middle metal layers are used for conducting current, and the bottom layer is used to connect to a heatsink. Electrical connections are made using through the ceramics, thus allowing a very low profile package with a large degree of overlap between conducting surfaces. This allows designers to create very low inductance and low thermal impedance packages.
\nThe module baseplate in silicon power module has normally been made from Cu in less-expensive modules and AlSiC in high-reliability modules. AlSiC is required for achieving the maximum benefit from AlN ceramic tiles, as the large CTE mismatch between AlN and Cu causes excessive stress, despite the high thermal conductivity of the system. High reliability baseplates are normally the largest single component of a module and the most expensive after the semiconductors. The trend in baseplate material is toward higher thermal conductivity, lower CTE, and higher mechanical strength. Base plates must also be finished to a high quality to give excellent bonding and interconnection with the other components. Enhanced cooling can be provided to the module by incorporating metal pin fins on the underside which can be used to directly liquid-cool the material, and these solutions have been widely used in automotive and traction applications to give low Zth from junction to case in the module [6]. Recently, MgSiC has emerged as a promising new baseplate material, which offers marginally higher thermal conductivity (up to around 210 W/mK compared with 170–180 for AlSiC) but which could be simpler to manufacture, and hence help to reduce cost [7].
\nFor high-power modules, thick copper bus bars are needed to handle high current loads without overheating. Solder interconnects have been very common as they are easily manufacturable and can be made in the same process as die attach soldering or substrate attach. As these other processes are becoming solder free, a new attach process for bus bars is beneficial, otherwise one soldering process will remain. Ultrasonic bonding is a mature process for bus-bar attach, which is already widely used in power electronics modules [8].
\nThe most widespread interconnection process for the backside of vertical power semiconductor devices is soldering, either using a solder paste which is mixture of flux and solder alloy; or using a solder preform which is a pre-fabricated foil of solder alloy, usually with the same surface area as the device to be soldered. The choice of alloy to be used for the die attach depends on several factors, such as whether or not the application has a requirement to be Pb free; the maximum processing temperature of other components in the module (such as passive SMT components); and cost. If there is no requirement to be Pb-free, this allows a wide choice of relatively inexpensive Pb-based alloys with melting points up to 300°C, albeit alloys which are far from being eutectic and could have a pasty phase 10°C wide or more between solidus and liquidus. High-melting point lead-bearing alloys are common in high-power, high-reliability power modules in which maximum Tj of the current generation of Si devices is 150°C and while it is theoretically possible to operate Si devices of around 200 V blocking voltage up to 200°C [9], is unlikely to increase above 175°C in high-power modules with blocking voltages greater than 3.3 kV due to device-physics limitations. This gives a temperature range of more than 100°C between the absolute maximum junction temperature of the devices and the melting point of the solder. When considering the suitability of an interconnection material, a useful parameter to define is the homologous temperature, TH, where
\nT (K) is the temperature of interest, which could be the mean operational temperature or the maximum junction temperature in this case, and TM (K) is the melting point of the material. In general, smaller homologous temperatures will give longer lifetimes in electronics packages either by operating as far as possible from the melting point of the solder, or by using a higher melting point solder; however, creep deformation can still occur at relatively low temperatures [10]. If TH is <0.4 this is considered mechanically stable, 0.4 < TM < 0.6 is considered to be the creep range, sensitive to strain, and TM > 0.6 is unable to bear engineering loads [9]. If we take 473 K (200°C) to be a useful operating temperature for SiC devices, the melting point of 1234 K (961°C) for pure silver gives a TH value of 0.38. In comparison, a Pb-rich solder with a melting point of 573 K (300°C) has a TH value of 0.82.
\nThe wide band gap of SiC or GaN allows devices to have a maximum junction temperature of around 300°C, this rules out any solder with a melting point close that figure. Solders with even higher melting points could be too costly, so there has been a great deal of effort in packaging R&D to find an alternative interconnection technology for Si and WBG devices. At the same time that WBG power devices are becoming mature, along with the associated demands on power electronics packaging, there is also the external pressure of environmental policy to eliminate hazardous substances from manufacturing. As mentioned earlier, Pb and its use in solder have been specifically targeted in legislation worldwide as a material which could be eliminated from consumer and industrial products. The European End of Life Vehicle (ELV) Directive sets targets for the reuse, recycling, and recovery of ELVs and their components [11] and the European Reduction of Hazardous Substances (RoHS) Directive Restriction of the Use of Certain Hazardous Substances in Electronic and Electrical Equipment specifically restricts the use of Pb. As of 2018, alloys with a Pb content of more than 85% are exempt from the RoHS restrictions but are subject to periodic exemption review.
\nIn 2010, a consortium of Bosch, Infineon Technologies, NXP, Freescale Semiconductor and STMicroelectronics formed with the aim of developing alternative processes for die attach in semiconductor packages to replace Pb solders, specifically high-melting point solders. Theconsortium is known as the Die Attach 5 (DA5) [12]. The DA5 are focusing on four potential replacements to high-Pb solder: Ag sintering; high electrical and thermal conductivity adhesives; alternative solders; and transient liquid phase soldering (TLPS) [13]. Alternative solders with appropriate properties are available, such as Au80Sn20, AuGe, and AuSi, but the high gold content makes them too expensive to be viable for most applications. Even the best conductive adhesives have poor electrical and thermal properties compared with solder. Ag sintering or transient liquid phase bonding provides a more promising alternative.
\nSintering is the process of forming a solid mass of material from smaller particles or flakes using temperature, pressure, or both, while remaining below the melting point of the sinter material. It is widely used in manufacturing of metallic and ceramic parts. In the context of power-electronics packaging, we refer to sintering as the process of forming interconnection layers by processing a layer of micro or nanoparticles (normally of Ag) by applying a temperature and pressure profile for a controlled period of time. The resulting porous Ag layer has excellent electrical and thermal conductivity and a melting point equal to bulk silver at 961°C, normally with some remaining porosity. The silver particles (also known as the filler) in the paste are combined with a capping agent, binders and solvents. The purpose of these additional materials is to ensure that the silver particles do not begin to sinter themselves together before the actual processing begins, and to make the consistency of the past suitable for screen printing or dispensing. A range of chemicals have been used by the different suppliers of sinter pastes, a useful summary of these was published in 2014 [14]. Sinter pastes are broadly classified as being either ‘pressured,’ that is they require pressure to be applied during processing, or ‘pressureless.’ Sintering is an attractive technology for Pb-free and high temperature operations because the processing temperature are similar to those already used for device soldering, and pressureless paste in particular is seen as a potential drop-in solution which would require the minimum of additional manufacturing equipment; however, it is common for even pressureless pastes to benefit from some application of pressure during the manufacturing stage to increase the deformation of the Ag filler particles and increase the diffusion rate of silver atoms. An early patent (1973) for using sintering to join metal parts illustrated the use of the technique in lap, butt, and T-joints [15]. Sintered connections are not a new technology in semiconductor device packaging, with sintered glass beads being used for insulating materials, and sintering ceramic sheets being used as substrates ( [16] for example). Only more recently, sintering has been used as a means to connect electronic components themselves [17] and particular power-semiconductor devices [18]. In 2006, a sintered interconnection for semiconductor device interconnection was described [19] which had an electrical conductivity of around 2.6 × 10−5 (Ωcm)−1, thermal conductivity of around 2.4 W/Kcm and apparent elastic modulus of 9 GPa. The high thermal conductivity of a sintered joint can lead to a small reduction in the thermal impedance Zth from junction to case compared with a soldered die, particularly in small modules where there are not many devices which may overlap thermally with one another. One team of researchers [20] observed 12% lower thermal impedance compared to a SAC305 solder connection (Figures 3 and 4).
\nCross section of a sintered die attach layer captured using scanning electron microscopy. The bright central area shows where the porosity of the layer has been revealed using focused ion beam (FIB) milling. The edges of the image show the apparent porosity after polishing with diamond suspension fluid. Image courtesy of Dynex Semiconductor Ltd.
Scanning electron microscope (SEM) images of the sinter layer under a semiconductor die showing the variation in porosity from the edges to the middle. The measured porosity on the left, middle, and right-hand side is 22.6, 19.5 and 26.1%, respectively. Image courtesy of Dynex Semiconductor Ltd.
Sintering for die attach in power electronics modules has been an area of extensive research and development and a recent consideration of the maturity of the state of the art has been published in [14, 21]. Ag sintering processes are mature enough for some manufacturers to ship power modules with sintered interconnections, for example it has been used by Semikron to produce entirely solder-free modules [9] and has been used successfully in bipolar devices for joining large thyristors to molybdenum plates. The SKiN module went even further and replaced the wirebonds with a PCB which is sintered to the topside of the device [22]. Uncertainty around the potential for widespread use of Ag sintering for die attach centers on a relative lack of data on the long term reliability compared with soldered interfaces, although many laboratory studies of reliability have been carried out that invariably show a large increase in the number of cycles-to-failure, sometimes by a factor of 10 compared to solder.
\nOne reason silver sintering is more challenging to apply to mass production because of the difficulty in carrying out in-line high-volume automated quality control of sintered joints. In IGBT module production lines, there is 100% screening of the solder layers using X-ray imaging to find and measure the presence of voids in the solder caused by contamination, poor wetting or process irregularities. Modern industrial X-ray imaging systems are capable of automatically detecting and measuring the area of voids for statistical process control and comparison against defined pass/fail criteria. Imperfections in sintered bond lines do not appear as voids in the die attach layer, a good sintered joint and a failed sintered joint look identical to most X-ray systems with the exception of an advanced 3D tomography system, but such analysis would take too long per scan and therefore be too expensive to use as a screening technique in large-scale production. Poor bonding during the sintering process which leaves thin planar areas of no contact between the device and sinter layer, or the sinter layer and the substrate, might potentially be identifiable using scanning acoustic microscopy (SAM). The other alternative would be to forgo complete screening and instead carry out destructive tests on samples from each production batch using the mechanical strength measured in a die-shear test for example as a figure of merit. An alternative destructive method used during process development is a bend test in which the die and substrate and bent over a mandrel, of the substrate cracks and deforms before the device adhesion fails, the sintered joint is considered to be good. Figure 5 shows the result of a bend test of 0.635 mm thick AlN active metal-brazed (AMB) tiles from the FIR3ST project power module. The tiles have been bent over a mandrel almost 90° which has caused the AlN ceramic and the SiC devices to fracture. The devices remain adhered to the surface.
\nSintered SiC MOSFETs on direct bonded copper (DBC) ceramic tiles after bend test. The substrate is bent through almost 90° and is cracked beneath the devices, which have remained adhered to the damaged surface. Image courtesy of Dynex Semiconductor Ltd.
The long-term reliability of Ag-sintered interfaces under thermomechanical cycling conditions is not as well understood as for soldered interconnections, but is an area of ongoing research. Sintered interconnections are vulnerable to the same driving forces of failure as soldered ones because they form a sandwich of materials with different coefficients of thermal expansion and experience temperature cycling with both fast time constants (caused by losses when the devices are switched and conducting current) and slow time constants (caused by heat soak of the overall system and the specific mission profile of the application). This causes thermomechanical stress which leads to cracking and delamination of the layers. Even if the CTE of the materials is closely matched thermomechanical failure modes will take place because power semiconductor modules are, in general, rarely in thermal equilibrium, but always have some temperature gradient across the vertical structure of the module. Studies have focused on how resilient sintered connections are compared with soldered interconnections under temperature cycling conditions, and on the nature of failure modes unique to sintered interfaces. Mechanical shear strength of nano-silver sintered die has been used as a measure of bond quality in 1.706 × 1.380 mm SiC SBDs [23]. It was found that the die shear strength was strongly related to the process time and temperature, with a 40 minute dwell at 300°C providing shear strength of around 40 MPa. These reduced by around 50% (the failure criteria defined in this study) after 5000 temperature cycles between 50 and 250°C. The reduction in shear strength was attributed to thermal-stress-induced dislocation creep leading to the formation of microcavities and grain boundaries.
\nThe properties of sintered interfaces have been found to be a function of the porosity and porosity is a function of the starting material and the pressure used in the process [24]. Even small changes in the porosity can have a large impact, for example increasing the porosity from 5 to 7% (in other words from 95% dense to 93% dense) decreased the thermal conductivity from 380 to 320 W/mK at 100°C, accompanied by a similar relative change in electrical conductivity. On the other hand, the coefficient of thermal expansion was found to be relatively constant at temperatures less than 250°C and between porosity of 5 and 38% [25]. One study found that an established production process capable of sintering DBC master cards up to 5″ × 7″ in area has a porosity of 5%, but that reducing pressure by a factor of 4, the porosity increases to around 20%. Figures 3 and 4 show SEM images of a 20 μm thick sinter layer showing the variation in porosity between the central area of the bond and the edges. Focused ion beam (FIB) milling is needed to reveal the true porosity under the polished surface.
\nA comparison of some properties between solder and silver sinter materials is shown in Table 1. Large area sintering has been investigated as a possible alternative to the use of solder for substrate to baseplate attachment [26]. A large ceramic tile (40 cm2) was sintered to a baseplate and subjected to temperature cycling between −40 and +150°C. The integrity of the sample was measured using scanning acoustic microscopy and the test was stopped after 3000 cycles when it was found that the sinter layer showed no signs of degradation, but the substrate was beginning to delaminate. This is a common trend found in many papers on sintering: practically, all of the research papers report considerable increases in reliability under temperature cycling and active cycling conditions, between a factor of 4 and 10 increases in the number of cycles to failure. This large increase in reliability of one specific interface usually means that another interface in the system becomes the first failure mode instead of the die attach layer, or other solder layer. In many cases, the weak point is the ceramic tile, which starts to delaminate and will quickly cause a large rise in the thermal resistance between junction and case once the delamination begins to impinge on the area under the devices.
\nParameter | \nPb-Sb solder | \nPb-free solder | \nAg nanopowder | \n
---|---|---|---|
CTE (ppm/K) | \n28 | \n20 | \n19–21 | \n
Thermal Conductivity (W/mK) | \n70 | \n70 (SnAg3.5) | \n240–290 | \n
Melting Point (°C) | \n183 | \n220 | \n~961 | \n
Electrical Conductivity | \n14.5 | \n8–12 | \n41 | \n
One negative aspect of sinter layers for both die and substrate attach is that the thin, stiff layers offer less stress relaxation to the structure, and the mechanical stress is transferred to other layers in the module. Figure 6 shows how from changing from soldering to sintering of substrates on a base plate the convex bow shape is completely reversed to become concave. The convex bow is necessary to ensure good thermal contact during operation as the module tends to flatten out due an effect similar to a bimetallic strip as it heats up, thus ensuring as large as possible contact area between base plate and heat sink. If the base plate has become concave, there will be a large area which is not contacted with the heat sink, so thermal impedance will increase, and as a result, the junction temperature.
\nThree profiles of nominally identical baseplates before processing (left), after substrates have been soldered (middle) and after substrates have been attached by sintering (right). The sintering process causes the baseplate to switch from a convex to a concave profile.
In any fully formed solder joint, there is a layer of intermetallic compounds formed as the metallization of the workpieces is dissolved into the molten solder. Typically, these intermetallic layers are of irregular thickness of around several microns. Diffusion soldering promotes the growth of the intermetallics throughout the bulk of the solder joint, so that at the end of the process, the entire solder layer is formed of intermetallics. Sn rich solders and copper metallized substrates are a common combination which give Cu6Sn5 and Cu3Sn intermetallics that have melting points of 416 and 676°C, respectively. A combination of Ag metallized die backside and Sn rich solder can give Ag3Sn (Tm = 480°C). Studies have shown that diffusion-soldered interconnections can have a factor of 10 higher reliability than conventional solder joints, at least as good as sintered interconnections [27].
\nAluminum wedge wirebonding remains the most widely used topside interconnection and has been an area of intense R&D to improve reliability. The most dramatic change is the use of copper wire instead of aluminum [30, 31]. The higher thermal and electrical conductivity of the wire allows increased current density for a given reliability or greater reliability at a given current density. The use of copper wire for die topside interconnection requires a special metallization on the topside of the chip, and some groups have experimented with the use of thick pads on the die topside to enhance the bondability of copper wire [32]. An alternative is the use of aluminum clad copper wire [33, 34, 35].
\nOne study introduced the concept of spot sintering braided cable connections to the topside of devices [36]. A power cycling comparison was made between soldered, wirebonded diodes; and sintered diodes with spot sintered braid topside interconnection. A load current of 90A was used with a constant on time and off time of 1 and 5 s respectively. This test method gave a ΔTj of between 86 and 100 K. The average number of cycles to failure of the soldered/wirebonded interconnection was 50 k cycles, for the sintered die, it was around 300 k cycles.
\nAdvantages of using unipolar wide-band gap devices in power electronics applications also have downsides. High switching speeds when switching inductive loads will cause large voltage overshoots which may exceed the breakdown capability of the device. The ringing of the voltage and current in the circuit caused by fast switching can have implications for EMC and interference at a system level. Figure 7 shows examples of waveforms from 3.3 kV rated devices.
\nTurn-on waveforms for a 3.3 kV Si IGBT with Si fast recovery diode (top), and the same IGBT but with SiC SBD (bottom). The first turn off of the unipolar SiC diode causes oscillation of the output current compared with the slower bipolar Si diode [
Packaging design has an important role to play in mitigating these unwanted side effects. Any electronic component always has some unwanted electrical characteristics and these are normally referred to as ‘stray’ or ‘parasitic’ properties. Stray capacitance, inductance, and resistance can all have negative effects in power electronics modules, and the fast switching speeds of WBG devices make it crucial to not only minimize these stray properties, but even to engineer them to specific values in order to optimize performance. Stray inductance causes voltage overshoots during periods of changing electrical current according to the relationship
\nwhere V is the overshoot voltage, L is the inductance, and di/dt is the rate of change of current. Clearly any inductance in the circuit combined with the high di/dt values associated with WBG devices will cause large voltage overshoots which could destroy the devices if the overall voltage exceeds the breakdown voltage of the device. Stray inductance can easily be minimized in principal by making the current carrying components planar, reducing depth, and overlapping terminals with opposite polarity as much as possible. In practice, however, this is more challenging to achieve: the presence of wire bonds for interconnection make it difficult to achieve really low parasitic inductance, say <5 nH per phase leg, and achieving low profile planar modules requires totally different module design concepts.
\nThe power module developed by the I2MPECT collaboration [38] achieved low stray inductance by adopting a wirebond free design, instead sintering a flexible PCB directly to the topside of the devices and using a low profile design with ultrasonically bonded bus bars for a solder free final package. Ag plated Si3N4 substrates are used and a pressure-assisted sintering processing connects SiC MOSFETs to the substrates, and the substrates are also sintered to the baseplate. The module is shown in Figure 8.
\nI2MPECT SiC power module. On the left, the complete package with lid. The right-hand side shows package internal solder-free structure, with ultrasonically bonded bus bars, double side sintering, and flexible PCB for topside die attach. Image courtesy of Dynex Semiconductor Ltd.
A 3.3 kV full SiC power module for rail traction applications has been reported [39] and further use of a full SiC 3.3 kV module rated at 450 A has been described in [40] and a similar package type has been used with 3rd generation SiC MOSFETs to give a module with 3.3 kV voltage rating and RDS (on) of 5 mΩ at 25°C and 13.8 mΩ at 175°C [41]. This package is becoming widely available from all the principal power module manufacturers, and while it uses relatively conventional packaging technology, for example, it still relies on extensive wire bonding for the topside connections to the devices, it focuses on using a new design approach to reduce the parasitic inductance. In rail traction applications, power modules normally consist of a single switch circuit topology combined together in the inverter to form phase legs. This newer style of package adopts a phase leg topology in a single package, which allows the bus bars to be designed in a way which allows a high degree of overlap between the DC+ and DC− bus bars, thus reducing the inductance while maintaining a module that can be manufactured on existing production lines.
\nIn [42], a packaging concept is presented featuring a modular full SiC design. In each switching element, 1200 V 80 mΩ SiC MOSFETs with solderable top and bottom sides are joined source-to-source with solder and copper bumps in a flipchip type arrangement. This allows a planar, low inductance, double-side cooled switch to be manufactured with a reported inductance [43] of around 12 nH at 10 kHz. VON of the MOSFETs was monitored during temperature cycling from −55°C to +150°C with 30 min soak at each temperature extreme and 15 min transition time. No sign of degradation was apparent after 500 cycles. Thermal simulation and FLIR camera measurement showed that with 100 W dissipated in each MOSFET, junction temperature could be kept below 80°C [44]. The main elements of this design are shown in Figure 9.
\nOverview of the module design concept described in [
In [45], a novel 10 kV, 60 A all SiC power module prototype was manufactured using third Generation Wolfspeed 350 mΩ SiC MOSFETs. Pressure-assisted sintering was used for the die attachment in a wirebond free arrangement which gave an overall thermal resistance in the range 0.11 to 0.14 K/W. This design allowed the low power-loop inductance of 4.4 nH to be achieved, while a direct impingement liquid cooled heat sink allows power densities up to 18.1 W/mm3.
\nMarket forces and technology trends push semiconductor power modules requirements to higher power density, higher operating temperature, higher efficiency, lower cost and higher reliability. Wide band gap power semiconductor devices and Si devices are placing new demands on packaging technology in order to realize the potential of the latest generation of devices to meet these requirements. Silicon devices still have a much larger market share across all applications in which the ever increasing demands outlined above are already providing challenges. As a result, it is often Si power modules that lead the way with the most advanced packaging technology because of the high demand for these devices and competitive market for high reliability products. Sintering, copper wire bonding, wirebond free, planar modules with low inductance have all been introduced with Si devices. It is almost counter intuitive that the first generations of SiC power devices have been brought to market using less advanced packaging technology, often simply being used as drop in replacements for Si devices in conventional packaging, so the full capability of the devices cannot be utilized. However, it seems certain that the time is near when the combination of advanced packaging and the latest generation of WBG devices is realized in mass production of power electronics modules.
\nThe authors wish to thank their colleagues at Dynex semiconductor and CRRC for their cooperation in proof reading the manuscript, to Dr. Yimin Zhao for her technical expertise on aspects of silver sintering, and to Anne Harris for her assistance regarding the FiRS3T and I2MPECT projects.
\nFascioliasis is an ancient food-borne neglected zoonotic disease of medical importance caused by some species of macroscopic and leaf-like digenetic trematodes in the genus
Since every continent is infested with these trematodes, 180 million people are at risk, while an estimated 2.4 million people living in more than 70 countries of the world are suffering from the scourge of fascioliasis [1, 5]. Meanwhile, it has been estimated that
Recently, there has been a significant increase in the global prevalence of human fascioliasis [1, 7] with a strong correlation with a high infection rate among ruminant definitive hosts [8].
A broad range of cosmopolitan freshwater snails in the family Limnaeidae are responsible for the transmission of fascioliasis. For instance,
Liver flukes have a complex life cycle with a wide range of mammalian definitive hosts [9]. Humans are accidental definitive host of
The number of eggs extruded by each adult worm per day varies from one definitive host to the other. Report has shown that as much as 25,000 eggs, 12,000 eggs, and 2,150 eggs could be extruded in sheep, cow, and black rats, respectively [16, 17]. Elsewhere, it has been reported that an individual liver fluke could extrude about 40,000 eggs per day [9]. These unembryonated eggs are transported in the bile medium to the small intestine, where they mix up with feces [18]. In ruminant definitive hosts, they are passed out in the pasture and undergo a period of embryonation under suitable ambient temperature and humidity.
Since freshwater body is crucial to the development of the larval stages of liver flukes [18], hatching takes place in response to external stimuli of light, temperature, and humidity [9, 19, 20]. The emerging free-swimming ciliated miracidia are genetically configured to locate a suitable Limnaeid snail intermediate host via thin films of water [21], in less than 24 hours through positive chemotactic and phototactic movements [9]. By means of their piercing stylets and proteolytic enzymes, they mechanically invade their snail hosts’ body wall and tissues [20, 22] and develop into sporocysts. The sporocysts further metamorphose into mother rediae, which develop into the daughter rediae. The metamorphosis in the snail host culminates in the emergence of cercariae, which are capable of passively infecting suitable vertebrate hosts and humans who drink infested water [18, 23, 24, 25]. Relative humidity above 65%, annual rainfall >100 mm, and ambient temperature of between 25 and 30°C have been reported as the factors that are suitable for the growth and shedding of cercariae [26, 27].
Finally, the cercariae locate the wet leaves of herbaceous plants by negative geotactic movement, encyst, and metamorphose into metacercariae. When ingested by suitable ruminant definitive hosts during grazing, the cyst is digested by the hosts’ enzyme and the metacercariae migrate to the duodenum where they re-encyst [18, 28]. Figure 1 below shows a summary of the life cycle of liver flukes.
Life cycle of liver flukes.
Fascioliasis is endemic in every continent of the world with the exception of Antarctica (Figure 1). The disease is being reported from Africa, Asia, the Caribbean, Europe, parts of Latin America, Middle East, and Oceania [29]. High transmission rate of human fascioliasis has been reported from the Andean highlands of Bolivia, Peru, the Nile valley, the Caspean sea basin, East Asia, and South East Asia [30].
In sub-Saharan Africa (SSA), fascioliasis has been reported in West Africa [12, 31], East Africa [32], and South African countries [33, 34]. However, it has also been reported in Egypt (outside SSA), North Africa [35, 36].
The distribution of fascioliasis in Nigeria covers every geo-political zone. There have been reports from North West [37, 38], North Central [39, 40], North East [41, 42], South West [43, 44], South South [45, 46] and South East [47, 48].
In 1939, Eugene Pavlovsky, a Russian Academician propounded the theory of disease focality, which suggests that some disease-causing organisms (pathogens) naturally occur in specific ecosystems [49, 50]. This implies that the population of the pathogens is an integral part of that natural landscape [51]. Characteristically, pathogens are transmitted in such settings irrespective of the presence of humans. Consequently, humans become accidental definitive hosts when their ecological niche overlaps with suitable hosts from such landscapes and they become infected after establishing contact [52]. Researchers have found out that the epidemiology of fascioliasis has a strong link with the ecology of the settings where the disease is transmitted [30].
Pavlovsky’s theory explains why fascioliasis is categorized as a focal infectious disease [29]. It could be transmitted independent of human presence. Drawing analogy from Pavlovsky’s theory, there are three important elements that play key roles in the transmission pattern of fascioliasis. These are the snail intermediate hosts, ruminant vertebrate hosts, and humans who are the accidental hosts (see Figure 2 below).
Global distribution of fascioliasis. Source: Reprinted from [
The transmission patterns of fascioliasis vary in different epidemiological settings [30]. In the last 20 years, some researchers proposed that the patterns of the disease can be classified as fascioliasis due to influx of immigrants, human endemic/non-human (animal) endemic areas, native or isolated cases, and the three human degrees of endemicity. The fourth classification is further grouped as hypoendemic [prevalence rate < 1% while Arithmetic Mean Intensity of Infection (AMII) < 50 eggs/gram of feces], mesoendemic [prevalence rate of 1–10% while AMII 50–300 eggs/gram of feces], and hyper-endemic [prevalence rate > 10% while AMII >300 eggs/gram of feces]. In mesoendemic settings, school-age children (SAC) [5–15 years] may have higher prevalence rates while in hyper-endemic settings, SAC usually record higher prevalence rates [54, 55].
The role of climate in the ecology of disease-causing organisms cannot be overemphasized. In fact, climate is regarded as a basic concept of ecology. Climate triggers environmental changes [56], which in turn affect the ecosystems where parasites are transmitted, reproduced, and complete their life cycles. Because life cycles, transmission rates, and pattern
Factors that predispose humans and animals to infectious diseases are referred to as risk factors. At different times and locations, many researchers have carried out spatial regression analysis of environmental variables to determine the risk factors of fascioliasis in humans and domestic ruminants. Consequently, significant associations have been described between fascioliasis and streams, wetlands, pastures [60], raising more than five sheep, dog ownership, familiarity with aquatic plants, drinking alfalfa juice, dizzy spells, history of jaundice, peripheral eosinophilia, presence of
Meanwhile, gender, age, epidemiological settings (rural, urban, or rural-urban), feeding habit, familial, and social factors have been reported as the major risk factors of fascioliasis among humans [55].
In areas that are hyper-endemic for human fascioliasis (e.g., Egypt and Bolivia), females have reportedly recorded higher prevalence and intensity rates [55, 63, 64].
All age groups have been found to be at risk of infection with fascioliasis but school-age children (5–15 years) have the highest prevalence and intensity [30, 64].
People from low-middle income countries are more likely to suffer from fascioliasis. However, inhabitants from developed countries could be infected when they feed on imported infested plants that elude quarantine measures [30]. During field trips, urban inhabitants could be at a high risk of infection due to fascioliasis [55].
Source of food and water consumed is an important epidemiological factor of human fascioliasis. Uncontrolled markets of vegetables (like carrot, cucumber, cabbage, onions, tomatoes, spinach, etc.) coupled with drinking infested water or beverages/juice made from local plants could predispose humans to infection since liver flukes have affinity for all plants. Reports have also shown that consumption of raw liver plays a vital role in infection transmission [55, 65].
Information on the prevalence of fascioliasis in Nigeria is more available compared to the intensity of infection: researchers seem to report the former more than the latter.
In a recent cross-sectional study conducted in North Central Nigeria where 686 fecal samples were collected from cattle in 11 villages, 110 were found to test positive for the eggs of
Meanwhile, a study carried out in South-South Nigeria revealed a fascioliasis prevalence (due to
Nevertheless, in the North-East, a fascioliasis (without distinction) prevalence of 28.2% was reported where 262 gall bladders of White Fulani cattle were examined [42]. In a recent longitudinal study carried out in another part of North-East, Nigeria, where 7640 samples of feces and gall bladders were collected from slaughtered cattle, sheep, and goats in seven local government areas, 3092 were positive for the eggs and adults of
Moreover, a cross-sectional study on bovine fascioliasis in southwestern Nigeria where 905 samples of feces were screened for the eggs and adult of both species shows the predominance of
Furthermore, a cross-sectional survey carried out in North-West Nigeria reported a prevalence of 27.68% after fecal and bile samples were examined from 224 cattle [37]. Another cross-sectional survey of slaughtered cattle, sheep, and goats carried out in similar zone reported a prevalence of 29.6% for
Finally, a longitudinal study carried out in South-East 8 years ago reported a prevalence of 17.2% after fecal and liver samples from 367 slaughtered sheep were examined for the presence of
The pattern of the prevalence rate of fascioliasis in Nigeria has proven the focal nature of the disease irrespective of the class of ruminant animals examined.
Oriental forms of liver flukes cause cholangiocarcinoma, a type of liver cancer that is peculiar to areas where
The parasitological means of examining fecal samples for the presence of liver flukes’ eggs is the use of microscope [68]. Eggs become visible after 8–10 weeks post infection. This, however, varies from one host species to another. The limitation of this method is that the sensitivity of the Fecal Egg Count (FEC) may be undermined by factors like the age of the host, quantity of water in each fecal sample, and how representative the number of aliquots is per fecal sample examined [70]. Furthermore, a report has shown that in definitive hosts suffering from the acute phase of the disease, adverse effects of fascioliasis become evident much earlier before the pre-patent period [71]. Consequently, at necropsy, quantitative fecal examination and finding the hepatic fluke load will grossly downplay the severity of the disease [69, 72].
Quite a number of relatively cheap antibody detection indirect enzyme-linked immunosorbent assays (ELISA) with high sensitivity and specificity have been developed. Most of these techniques are based on excretory-secretory products and cathepsin L proteases [70, 73].
Increase in parasite-specific IgG (which becomes detectable after 4 weeks post infection) is peculiar to infection with fascioliasis [74]. The limitation of this technique is that after many months of successful treatment, antibodies could remain in serum, giving a false impression that the infection status is positive [70].
Excellent specificity and sensitivity has been reported for a serodiagnostic technique developed in 2011 for human fascioliasis. SeroFluke, as it is called, is a lateral flow test which has fared better compared with ELISA test (MM3-SERO) [70, 75].
Nonetheless, report has shown the superiority of antigen detection to that of antibody in the diagnosis of human fascioliasis. Coproantigens (antigens in fecal samples) are preferred to antigenemia (the presence of antigens in blood) because in the latter, circulating antigens disappear soon in the serum of patients. Besides, most of them appear in form of immune complex which are not freely detectable [76].
Less than a decade ago, a nested-PCR was developed to boost the sensitivity and specificity of current diagnostic techniques with the view that the fascioliasis could be detected in the feces of sheep 2 weeks post infection. This method entails the amplification of a 423 bp fragment of the Cytochrome C Oxidase 1 gene [70, 77]. Interestingly, similar result was achieved a year later in lesser time by amplifying a 292 bp fragment of ITS2 gene [70, 78]. Because molecular diagnosis using PCR is not readily available everywhere and as well undermined by irreproducibility of published methods, loop-mediated isothermal amplification (LAMP) has been introduced as an alternative. LAMP has proven to be more specific and sensitive by detecting fascioliasis 1 week post infection in sheep within a much shorter time—about 2½ times faster than PCR [70, 79].
Chemotherapeutic approach has been in practice in fascioliasis control for 20 years. Based on its effectiveness, it has been predicted that the
The single dose of 10 mg/kg body weight is effective against the adult in the bile ducts and on immature flukes migrating through the liver [80, 85]. However, TCZ resistance has been reported in animals [87, 88] and in humans [89]. Reports have shown that drug resistance could frustrate fascioliasis control programmes [18]. Besides, TCZ is not commercially available because it is solely distributed by Novartis Pharma. Inc. (Basel, Switzerland). Consequently, it is not recommended for mass administration of medicines (MAM) [80, 90]. The unavailability of the drug, specifically to treat fascioliasis, has been reported to result in outbreaks of the disease more than a decade ago [91].
Periodic antihelmintic use at 12–13 week intervals is effective against both mature and immature flukes. By this strategic control measure, intensity of infection with liver flukes significantly reduces over time. In the tropics where incidence of fascioliasis occurs all year round, annual treatment of up to four times is recommended [82, 92].
In Nigeria, some parts have reported seasonal trends in fascioliasis while some Southern parts of the country have reported an all-year-round occurrence [93]. A recent 46- year meta-analysis of the prevalence and distribution of helminthes of veterinary and zoonotic importance in Nigeria has identified failure of control programmes in the area of strategic deworming, snail host control, and adequate sanitation as the reason for the highest pooled prevalence in southwestern Nigeria [38]. Some authorities recommend that cattle be dewormed regularly [94], while others recommend treatment upon onset of clinical fascioliasis. Meanwhile, two or three annual treatments have been proposed: at the start of the rainy season, mid rainy season, and at the start of the dry season [95]. Currently, the anthelminthic drugs in use in Nigeria include: albendazole, nitroxynil, clorsulon and levamisole. However, a report has shown that the drug of choice against fascioliasis (triclabendazole) is not available for use in Nigeria [82].
The emerging drug-resistant strains of liver flukes have led to the need for vaccine development. Despite the immense effort of researchers in this regard, no commercial vaccine is available yet [96]. Cysteine proteases produced by every stage in the life cycle of the liver flukes are common virulence mediators [97], which mediate biological functions like excystment, tissue invasion, and immune evasion [98].
Adult fluke cathepsin L and newly excysted juvenile (NEJ) cathepsin B are the prominent proteolytic enzymes of their respective excretory secretory (ES) materials [97]. Cathepsin L5 and cathepsin B synthesized by
Recombinant protein expression is critical to the assessment of cysteine protein vaccine potential [97]. The yeast expression system has been a useful tool for the functional expression of cathepsin L1 and L2 [102], cathepsin L5, and cathepsin B [101].
A larger part of these vaccine candidates was first isolated as native proteins from adult worm ES products. Several of these early antigens, including cathepsin L proteases, glutathione S-transferase (GST), and fatty acid binding protein (FABP) significantly reduced worm burden, egg output, and liver pathology in cattle and sheep [96, 103].
Fascioliasis has been established as an important foodborne disease of veterinary and zoonotic importance. Climate change, emerging drug resistance, and the development of new parasite strains through hybridization are the current challenges that could potentially alter the epidemiology of the disease in the nearest future [70]. To this end, researchers need to step up their effort to produce promising vaccines that offer maximum protection to farm animals and humans and as well contribute immensely to global elimination of the disease by reducing its prevalence and intensity. Government of countries in the tropics and subtropics should endeavor to provide more funds for researchers.
The authors sincerely appreciate the effort of Mr. Osuntuyi Mabayoje Pius who did the art work on the Life Cycle of liver flukes. We extend our gratitude to the World Health Organization for granting us the permission to use the map of the world showing the global distribution of fascioliasis under the request ID 312094.
The authors do not have any conflicts of interest to declare.
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\n\nBook Chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen maintains a very flexible Copyright Policy that ensures that there is no copyright transfer to the publisher. Therefore, Authors retain exclusive copyright to their work. All Monographs are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) and journal articles are distributed under a Creative Commons 4.0 International Licence.
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Anthocyanins are responsible for the color of red grapes and wines, hydroxycinnamic and hydroxybenzoic acids act as copigments, stilbenes as antioxidants and the flavan-3-ols are mainly responsible for the astringency, bitterness and structure of wines, being involved also in the color stabilization during aging. This chapter will focus on the chemical structures of the main polyphenols, their identification and quantification in grapes and wines by advanced analytical techniques, highlighting also the maceration and aging impact on the polyphenols evolution. The factors influencing the phenolic accumulation in grapes are also reviewed, emphasizing as well the relationship between phenolic content in grapes versus wine. Polyphenolic changes during the wine making process are highlighted along with the main polyphenol extraction methods and analysis techniques. This research will contribute to the improvement in the knowledge of polyphenols: their presence in grapes, the relationship with wine quality and the influence of the external factors on their evolution.",book:{id:"6077",slug:"grapes-and-wines-advances-in-production-processing-analysis-and-valorization",title:"Grapes and Wines",fullTitle:"Grapes and Wines - Advances in Production, Processing, Analysis and Valorization"},signatures:"Violeta-Carolina Niculescu, Nadia Paun and Roxana-Elena Ionete",authors:[{id:"187102",title:"Dr.",name:"Roxana",middleName:null,surname:"Ionete",slug:"roxana-ionete",fullName:"Roxana Ionete"},{id:"206056",title:"Dr.",name:"Violeta",middleName:"Carolina",surname:"Niculescu",slug:"violeta-niculescu",fullName:"Violeta Niculescu"},{id:"207020",title:"Mrs.",name:"Nadia",middleName:null,surname:"Paun",slug:"nadia-paun",fullName:"Nadia Paun"}]},{id:"58638",doi:"10.5772/intechopen.72823",title:"Occurrence and Analysis of Sulfur Compounds in Wine",slug:"occurrence-and-analysis-of-sulfur-compounds-in-wine",totalDownloads:1953,totalCrossrefCites:4,totalDimensionsCites:11,abstract:"Sulfur compounds play an important role in the sensory characteristics of wine. These molecules can derive from the grape, in which the non-volatile forms are usually present as glycosylated molecules, the metabolic activities of yeast and bacteria, the chemical reactions taking place during the wine aging and storage, and the environment. The sulfur compounds include molecules positively correlated to the aromatic profile of wine, namely the volatile thiols, and are responsible for certain defects, imparting notes described as cabbage, onion, rotten egg, garlic, sulfur and rubber. Due to the low concentration of these molecules in wine, their high reactivity and the matrix complexity, the analytical methods which enable their detection and quantification represent a challenge. The solid phase microextraction (SPME) technique has been developed for sulfur compounds associated with off-flavors. The analysis of volatile thiols usually requires a derivatization followed by gas chromatography (GC)-MS or UPLC-MS methods. Besides the sulfur-containing aromas, another sulfur compound that deserves mention is the reduced glutathione (GSH) which has been widely studied due to its antioxidant properties. The analysis of GSH has been proposed using a liquid chromatography technique (HPLC or UPLC) coupled with fluorescence, MS and UV detectors.",book:{id:"6077",slug:"grapes-and-wines-advances-in-production-processing-analysis-and-valorization",title:"Grapes and Wines",fullTitle:"Grapes and Wines - Advances in Production, Processing, Analysis and Valorization"},signatures:"Daniela Fracassetti and Ileana Vigentini",authors:[{id:"207271",title:"Dr.",name:"Daniela",middleName:null,surname:"Fracassetti",slug:"daniela-fracassetti",fullName:"Daniela Fracassetti"},{id:"220967",title:"Dr.",name:"Ileana",middleName:null,surname:"Vigentini",slug:"ileana-vigentini",fullName:"Ileana Vigentini"}]},{id:"66619",doi:"10.5772/intechopen.85692",title:"Contribution of the Microbiome as a Tool for Estimating Wine’s Fermentation Output and Authentication",slug:"contribution-of-the-microbiome-as-a-tool-for-estimating-wine-s-fermentation-output-and-authenticatio",totalDownloads:1090,totalCrossrefCites:5,totalDimensionsCites:9,abstract:"Wine is the alcoholic beverage which is the product of alcoholic fermentation, usually, of fresh grape must. Grape microbiome is the source of a vastly diverse pool of filamentous fungi, yeast, and bacteria, the combination of which plays a crucial role for the quality of the final product of any grape must fermentation. In recent times, the significance of this pool of microorganisms has been acknowledged by several studies analyzing the microbial ecology of grape berries of different geographical origins, cultural practices, grape varieties, and climatic conditions. Furthermore, the microbial evolution of must during fermentation process has been overstudied. The combination of the microbial evolution along with metabolic and sensorial characterizations of the produced wines could lead to the suggestion of the microbial terroir. These aspects are today leading to open a new horizon for products such as wines, especially in the case of PDO-PGI products. The aims of this review is to describe (a) how the microbiome communities are dynamically differentiated during the process of fermentation from grape to ready-to-drink wine, in order to finalize each wine’s unique sensorial characteristics, and (b) whether the microbiome could be used as a fingerprinting tool for geographical indication, based on high-throughput sequencing (HTS) technologies. Nowadays, it has been strongly indicated that microbiome analysis of grapes and fermenting musts using next-generation sequencing (NGS) could open a new horizon for wine, in the case of protected designation of origin (PDO) and protected geographical indication (PGI) determination.",book:{id:"8054",slug:"advances-in-grape-and-wine-biotechnology",title:"Advances in Grape and Wine Biotechnology",fullTitle:"Advances in Grape and Wine Biotechnology"},signatures:"Dimitrios A. Anagnostopoulos, Eleni Kamilari and Dimitrios Tsaltas",authors:[{id:"180885",title:"Associate Prof.",name:"Dimitris",middleName:null,surname:"Tsaltas",slug:"dimitris-tsaltas",fullName:"Dimitris Tsaltas"},{id:"203761",title:"MSc.",name:"Dimitris",middleName:null,surname:"Anagnostopoulos",slug:"dimitris-anagnostopoulos",fullName:"Dimitris Anagnostopoulos"},{id:"271801",title:"Ms.",name:"Elena",middleName:null,surname:"Kamilari",slug:"elena-kamilari",fullName:"Elena Kamilari"}]},{id:"67444",doi:"10.5772/intechopen.86443",title:"Somatic Variation and Cultivar Innovation in Grapevine",slug:"somatic-variation-and-cultivar-innovation-in-grapevine",totalDownloads:1032,totalCrossrefCites:4,totalDimensionsCites:9,abstract:"Paradoxically, continuous vegetative multiplication of traditional grapevine cultivars aimed to maintain cultivar attributes in this highly heterozygous species ends in the accumulation of considerable somatic variation. This variation has long contributed to cultivar adaptation and evolution under changing environmental and cultivation conditions and has also been a source of novel traits. Understanding how this somatic variation originates provides tools for genetics-assisted tracking of selected variants and breeding. Potentially, the identification of the mutations causing the observed phenotypic variation can now help to direct genome editing approaches to improve the genotype of elite traditional cultivars. Molecular characterization of somatic variants can also generate basic information helping to understand gene biological function. In this chapter, we review the state of the art on somatic variation in grapevine at phenotypic and genome sequence levels, present possible strategies for the study of this variation, and describe a few examples in which the genetic and molecular basis or very relevant grapevine traits were successfully identified.",book:{id:"8054",slug:"advances-in-grape-and-wine-biotechnology",title:"Advances in Grape and Wine Biotechnology",fullTitle:"Advances in Grape and Wine Biotechnology"},signatures:"Pablo Carbonell-Bejerano, Carolina Royo, Nuria Mauri, Javier Ibáñez and José Miguel Martínez Zapater",authors:[{id:"287215",title:"Prof.",name:"Jose Miguel",middleName:null,surname:"Martinez Zapater",slug:"jose-miguel-martinez-zapater",fullName:"Jose Miguel Martinez Zapater"},{id:"287226",title:"Dr.",name:"Javier",middleName:null,surname:"Ibáñez",slug:"javier-ibanez",fullName:"Javier Ibáñez"},{id:"300441",title:"Dr.",name:"Pablo",middleName:null,surname:"Carbonell-Bejerano",slug:"pablo-carbonell-bejerano",fullName:"Pablo Carbonell-Bejerano"},{id:"300442",title:"Dr.",name:"Carolina",middleName:null,surname:"Royo",slug:"carolina-royo",fullName:"Carolina Royo"},{id:"300444",title:"Dr.",name:"Nuria",middleName:null,surname:"Mauri",slug:"nuria-mauri",fullName:"Nuria Mauri"}]},{id:"57946",doi:"10.5772/intechopen.71627",title:"Microbiological, Physical, and Chemical Procedures to Elaborate High-Quality SO2-Free Wines",slug:"microbiological-physical-and-chemical-procedures-to-elaborate-high-quality-so2-free-wines",totalDownloads:1613,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"Sulfur dioxide (SO2) is the most preservative used in the wine industry and has been widely applied, as antioxidant and antibacterial agent. However, the use of sulfur dioxide implicates a range of adverse clinical effects. Therefore, the replacement of the SO2 content in wines is one of the most important challenges for scientist and winemakers. This book chapter gives an overview regarding different microbiological, physical, and chemical alternatives to elaborate high-quality SO2-free wines. In the present chapter, original research articles as well as review articles and results obtained by the research group of the Wine Technology Center (VITEC) are shown. This study provides useful information related to this novel and healthy type of wines, highlighting the development of winemaking strategies and procedures.",book:{id:"6077",slug:"grapes-and-wines-advances-in-production-processing-analysis-and-valorization",title:"Grapes and Wines",fullTitle:"Grapes and Wines - Advances in Production, Processing, Analysis and Valorization"},signatures:"Raúl Ferrer-Gallego, Miquel Puxeu, Laura Martín, Enric Nart, Claudio\nHidalgo and Imma Andorrà",authors:[{id:"207221",title:"Dr.",name:"Raúl",middleName:null,surname:"Ferrer-Gallego",slug:"raul-ferrer-gallego",fullName:"Raúl Ferrer-Gallego"},{id:"208597",title:"Dr.",name:"Miquel",middleName:null,surname:"Puxeu",slug:"miquel-puxeu",fullName:"Miquel Puxeu"},{id:"208598",title:"Dr.",name:"Laura",middleName:null,surname:"Martín",slug:"laura-martin",fullName:"Laura Martín"},{id:"208599",title:"Mr.",name:"Enric",middleName:null,surname:"Nart",slug:"enric-nart",fullName:"Enric Nart"},{id:"208600",title:"Dr.",name:"Claudio",middleName:null,surname:"Hidalgo",slug:"claudio-hidalgo",fullName:"Claudio Hidalgo"},{id:"208601",title:"Dr.",name:"Imma",middleName:null,surname:"Andorrà",slug:"imma-andorra",fullName:"Imma Andorrà"}]}],mostDownloadedChaptersLast30Days:[{id:"58638",title:"Occurrence and Analysis of Sulfur Compounds in Wine",slug:"occurrence-and-analysis-of-sulfur-compounds-in-wine",totalDownloads:1953,totalCrossrefCites:4,totalDimensionsCites:11,abstract:"Sulfur compounds play an important role in the sensory characteristics of wine. These molecules can derive from the grape, in which the non-volatile forms are usually present as glycosylated molecules, the metabolic activities of yeast and bacteria, the chemical reactions taking place during the wine aging and storage, and the environment. The sulfur compounds include molecules positively correlated to the aromatic profile of wine, namely the volatile thiols, and are responsible for certain defects, imparting notes described as cabbage, onion, rotten egg, garlic, sulfur and rubber. Due to the low concentration of these molecules in wine, their high reactivity and the matrix complexity, the analytical methods which enable their detection and quantification represent a challenge. The solid phase microextraction (SPME) technique has been developed for sulfur compounds associated with off-flavors. The analysis of volatile thiols usually requires a derivatization followed by gas chromatography (GC)-MS or UPLC-MS methods. Besides the sulfur-containing aromas, another sulfur compound that deserves mention is the reduced glutathione (GSH) which has been widely studied due to its antioxidant properties. The analysis of GSH has been proposed using a liquid chromatography technique (HPLC or UPLC) coupled with fluorescence, MS and UV detectors.",book:{id:"6077",slug:"grapes-and-wines-advances-in-production-processing-analysis-and-valorization",title:"Grapes and Wines",fullTitle:"Grapes and Wines - Advances in Production, Processing, Analysis and Valorization"},signatures:"Daniela Fracassetti and Ileana Vigentini",authors:[{id:"207271",title:"Dr.",name:"Daniela",middleName:null,surname:"Fracassetti",slug:"daniela-fracassetti",fullName:"Daniela Fracassetti"},{id:"220967",title:"Dr.",name:"Ileana",middleName:null,surname:"Vigentini",slug:"ileana-vigentini",fullName:"Ileana Vigentini"}]},{id:"57497",title:"Recovering Ancient Grapevine Varieties: From Genetic Variability to In Vitro Conservation, A Case Study",slug:"recovering-ancient-grapevine-varieties-from-genetic-variability-to-in-vitro-conservation-a-case-stud",totalDownloads:1768,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"A great number of varieties have been described in grapevine; however, few of them are currently in use. The increasing concern on varietal diversity loss has encouraged actions for recovering and preserving grapevine germplasm, which represents valuable resources for breeding as well as for diversification in grapevine-derived products. On the other hand, it is expected that this important crop, which is distributed in warm areas worldwide, will suffer the climate changes. Therefore, it is also convenient the identification of intravarietal variability and the recovery of accessions well adapted to particular environments. In this chapter, we will contribute to highlight the importance of recovering ancient materials, the usefulness of SSR markers to determine their molecular profile, the importance to analyze their virus status, and the possibilities that offer biotechnological tools for virus sanitation and in vitro storage as a complement of field preservation. In this context, we have evaluated different grapevine accessions and developed in vitro culture protocols for micropropagation, sanitation, and storage grapevine cultivars. In this work, we report the results obtained for the historic variety “Valencí Blanc” (or “Beba”) and the historic and endangered variety “Esclafagerres” (“Esclafacherres” or “Esclafacherris”).",book:{id:"6077",slug:"grapes-and-wines-advances-in-production-processing-analysis-and-valorization",title:"Grapes and Wines",fullTitle:"Grapes and Wines - Advances in Production, Processing, Analysis and Valorization"},signatures:"Carmina Gisbert, Rosa Peiró, Tania San Pedro, Antonio Olmos,\nCarles Jiménez and Julio García",authors:[{id:"207745",title:"Dr.",name:"Carmina",middleName:null,surname:"Gisbert",slug:"carmina-gisbert",fullName:"Carmina Gisbert"},{id:"207748",title:"Dr.",name:"Rosa María",middleName:null,surname:"Peiró",slug:"rosa-maria-peiro",fullName:"Rosa María Peiró"},{id:"207749",title:"Ms.",name:"Tania",middleName:null,surname:"San Pedro Galán",slug:"tania-san-pedro-galan",fullName:"Tania San Pedro Galán"},{id:"207750",title:"Dr.",name:"Antonio",middleName:null,surname:"Olmos",slug:"antonio-olmos",fullName:"Antonio Olmos"}]},{id:"58633",title:"The Evolution of Polyphenols from Grapes to Wines",slug:"the-evolution-of-polyphenols-from-grapes-to-wines",totalDownloads:2023,totalCrossrefCites:5,totalDimensionsCites:13,abstract:"Polyphenols play an important role in the quality of wines, due to their contribution to the wine sensory properties: color, astringency and bitterness. They act as antioxidants, having positive role in human health. They can be divided into non-flavonoid (hydroxybenzoic and hydroxycinnamic acids and stilbenes) and flavonoid compounds (anthocyanins, flavan-3-ols and flavonols). Anthocyanins are responsible for the color of red grapes and wines, hydroxycinnamic and hydroxybenzoic acids act as copigments, stilbenes as antioxidants and the flavan-3-ols are mainly responsible for the astringency, bitterness and structure of wines, being involved also in the color stabilization during aging. This chapter will focus on the chemical structures of the main polyphenols, their identification and quantification in grapes and wines by advanced analytical techniques, highlighting also the maceration and aging impact on the polyphenols evolution. The factors influencing the phenolic accumulation in grapes are also reviewed, emphasizing as well the relationship between phenolic content in grapes versus wine. Polyphenolic changes during the wine making process are highlighted along with the main polyphenol extraction methods and analysis techniques. This research will contribute to the improvement in the knowledge of polyphenols: their presence in grapes, the relationship with wine quality and the influence of the external factors on their evolution.",book:{id:"6077",slug:"grapes-and-wines-advances-in-production-processing-analysis-and-valorization",title:"Grapes and Wines",fullTitle:"Grapes and Wines - Advances in Production, Processing, Analysis and Valorization"},signatures:"Violeta-Carolina Niculescu, Nadia Paun and Roxana-Elena Ionete",authors:[{id:"187102",title:"Dr.",name:"Roxana",middleName:null,surname:"Ionete",slug:"roxana-ionete",fullName:"Roxana Ionete"},{id:"206056",title:"Dr.",name:"Violeta",middleName:"Carolina",surname:"Niculescu",slug:"violeta-niculescu",fullName:"Violeta Niculescu"},{id:"207020",title:"Mrs.",name:"Nadia",middleName:null,surname:"Paun",slug:"nadia-paun",fullName:"Nadia Paun"}]},{id:"67760",title:"Production and Marketing of Low-Alcohol Wine",slug:"production-and-marketing-of-low-alcohol-wine",totalDownloads:1300,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"Moderate wine consumption may be associated with specific health benefits and a healthy lifestyle. However, increased amounts of ethanol are cytotoxic and associated with adverse health outcomes. Alcohol reduction in wine might be an avenue to reduce alcohol related harm without forcing consumers to compromise on lifestyle and benefit from positive aspects of moderate consumption. The aim of this review is to give an overview of viticultural and pre and post fermentation methods to produce low-alcohol wine, and to summarize the current evidence on the consumer acceptance and behaviour related to low-alcohol wine. Strategies for the labelling and marketing of wines with reduced alcohol content are discussed.",book:{id:"8054",slug:"advances-in-grape-and-wine-biotechnology",title:"Advances in Grape and Wine Biotechnology",fullTitle:"Advances in Grape and Wine Biotechnology"},signatures:"Tamara Bucher, Kristine Deroover and Creina Stockley",authors:[{id:"289140",title:"Dr.",name:"Creina",middleName:null,surname:"Stockley",slug:"creina-stockley",fullName:"Creina Stockley"},{id:"289141",title:"Dr.",name:"Tamara",middleName:null,surname:"Bucher",slug:"tamara-bucher",fullName:"Tamara Bucher"},{id:"289142",title:"Ms.",name:"Kristine",middleName:null,surname:"Deroover",slug:"kristine-deroover",fullName:"Kristine Deroover"}]},{id:"57946",title:"Microbiological, Physical, and Chemical Procedures to Elaborate High-Quality SO2-Free Wines",slug:"microbiological-physical-and-chemical-procedures-to-elaborate-high-quality-so2-free-wines",totalDownloads:1613,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"Sulfur dioxide (SO2) is the most preservative used in the wine industry and has been widely applied, as antioxidant and antibacterial agent. However, the use of sulfur dioxide implicates a range of adverse clinical effects. Therefore, the replacement of the SO2 content in wines is one of the most important challenges for scientist and winemakers. This book chapter gives an overview regarding different microbiological, physical, and chemical alternatives to elaborate high-quality SO2-free wines. In the present chapter, original research articles as well as review articles and results obtained by the research group of the Wine Technology Center (VITEC) are shown. This study provides useful information related to this novel and healthy type of wines, highlighting the development of winemaking strategies and procedures.",book:{id:"6077",slug:"grapes-and-wines-advances-in-production-processing-analysis-and-valorization",title:"Grapes and Wines",fullTitle:"Grapes and Wines - Advances in Production, Processing, Analysis and Valorization"},signatures:"Raúl Ferrer-Gallego, Miquel Puxeu, Laura Martín, Enric Nart, Claudio\nHidalgo and Imma Andorrà",authors:[{id:"207221",title:"Dr.",name:"Raúl",middleName:null,surname:"Ferrer-Gallego",slug:"raul-ferrer-gallego",fullName:"Raúl Ferrer-Gallego"},{id:"208597",title:"Dr.",name:"Miquel",middleName:null,surname:"Puxeu",slug:"miquel-puxeu",fullName:"Miquel Puxeu"},{id:"208598",title:"Dr.",name:"Laura",middleName:null,surname:"Martín",slug:"laura-martin",fullName:"Laura Martín"},{id:"208599",title:"Mr.",name:"Enric",middleName:null,surname:"Nart",slug:"enric-nart",fullName:"Enric Nart"},{id:"208600",title:"Dr.",name:"Claudio",middleName:null,surname:"Hidalgo",slug:"claudio-hidalgo",fullName:"Claudio Hidalgo"},{id:"208601",title:"Dr.",name:"Imma",middleName:null,surname:"Andorrà",slug:"imma-andorra",fullName:"Imma Andorrà"}]}],onlineFirstChaptersFilter:{topicId:"1411",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81659",title:"State-of-the-Art Knowledge about 2,4,6-Trichloroanisole (TCA) and Strategies to Avoid Cork Taint in Wine",slug:"state-of-the-art-knowledge-about-2-4-6-trichloroanisole-tca-and-strategies-to-avoid-cork-taint-in-wi",totalDownloads:26,totalDimensionsCites:0,doi:"10.5772/intechopen.103709",abstract:"Cork stoppers have been used for many centuries to seal wine in various vessels. Therefore, corks have become a traditional part of wine packaging in many countries and still play an important role for the entire wine industry. Nowadays, there is a wide option of bottle cork stoppers on the market, such as natural corks, agglomerated and technical stoppers (1 + 1), etc. These cork closures have a number of advantages, including positive sustainable and ecological aspects. Natural cork material can also be responsible for cork taint, which imparts musty/moldy or wet cardboard off-odors to the wine. However, corks are not the only source of cork taint in wine, as will be shown in the present chapter. Over the past decades, a number of compounds have been detected that can contribute to the cork taint. Among them, haloanisoles play a major role, in particular 2,4,6-trichloroanisole (TCA), which has been shown to be responsible for 50–80% or more of musty defect cases in wine. Currently, the cork and wine industries have developed a number of tools and technologies to effectively prevent cork tait in wine or to remove it if the wine is already contaminated. These practical as well as analytical questions about the TCA defects are the subject of the actual chapter.",book:{id:"10901",title:"Grapes and Wine",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg"},signatures:"Andrii Tarasov, Miguel Cabral, Christophe Loisel, Paulo Lopes, Christoph Schuessler and Rainer Jung"},{id:"78620",title:"Table Grapes: There Is More to Vitiviniculture than Wine…",slug:"table-grapes-there-is-more-to-vitiviniculture-than-wine",totalDownloads:139,totalDimensionsCites:0,doi:"10.5772/intechopen.99986",abstract:"Table grapes are fruits intended for fresh human consumption due to their sensory attributes and nutritional value. The objective of this chapter is to review the existing knowledge about table grapes, including a description of different varieties, with particular emphasis on the new highly appreciated seedless varieties. Following an introductory note on the world distribution and production of table grapes, also considering the impact of climate change, selected varieties of table grapes will be characterized in terms of their physiology, postharvest features, and consumer preferences. A morphological description of each variety, with emphasis on grape skin, grape rachis and grape cluster will be included. A final note on the drying of table grapes into raisins, and the most appropriate varieties for drying, will be given. The major changes occurring throughout the growth, development, and ripening phases of table grapes production will be discussed, regarding both physical (skin color and skin and pulp texture) and chemical (phenolic compounds, sugar content and acidity) parameters, as well as growth regulators.",book:{id:"10901",title:"Grapes and Wine",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg"},signatures:"Ana Cristina Agulheiro-Santos, Marta Laranjo and Sara Ricardo-Rodrigues"},{id:"79500",title:"New Insights about the Influence of Yeasts Autolysis on Sparkling Wines Composition and Quality",slug:"new-insights-about-the-influence-of-yeasts-autolysis-on-sparkling-wines-composition-and-quality",totalDownloads:92,totalDimensionsCites:0,doi:"10.5772/intechopen.101314",abstract:"Sparkling wines elaborated using the traditional method undergo a second fermentation in the bottle. This process involves an aging time in contact with the lees, which enriches the wine in various substances, especially proteins, mannoproteins and polysaccharides, thanks to the autolysis of the yeasts. As a result of this yeast autolysis, sparkling wines benefit from better integration of carbon dioxide and a clear sensory improvement, especially in the case of long aging. This chapter synthetizes the main results that our research group has obtained about the influence of yeasts autolysis on sparkling wines composition and quality during last years, making special emphasis on the capacity of the lees to release proteins and polysaccharides as well as on their capacity to consume oxygen and thus protect the sparkling wines from oxidation.",book:{id:"10901",title:"Grapes and Wine",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg"},signatures:"Pere Pons-Mercadé, Pol Giménez, Glòria Vilomara, Marta Conde, Antoni Cantos, Nicolas Rozès, Sergi Ferrer, Joan Miquel Canals and Fernando Zamora"},{id:"79110",title:"Microbial Decontamination by Pulsed Electric Fields (PEF) in Winemaking",slug:"microbial-decontamination-by-pulsed-electric-fields-pef-in-winemaking",totalDownloads:80,totalDimensionsCites:0,doi:"10.5772/intechopen.101112",abstract:"Pulsed Electric Fields (PEF) is a non-thermal technique that causes electroporation of cell membranes by applying very short pulses (μs) of a high-intensity electric field (kV/cm). Irreversible electroporation leads to the formation of permanent conductive channels in the cytoplasmic membrane of cells, resulting in the loss of cell viability. This effect is achieved with low energy requirements and minimal deterioration of quality. This chapter reviews the studies hitherto conducted to evaluate the potential of PEF as a technology for microbial decontamination in the winemaking process for reducing or replacing the use of SO2, for guaranteeing reproducible fermentations or for wine stabilization.",book:{id:"10901",title:"Grapes and Wine",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg"},signatures:"Carlota Delso, Alejandro Berzosa, Jorge Sanz, Ignacio Álvarez and Javier Raso"},{id:"78993",title:"pH Control and Aroma Improvement Using the Non-Saccharomyces Lachancea thermotolerans and Hanseniaspora spp. Yeasts to Improve Wine Freshness in Warm Areas",slug:"ph-control-and-aroma-improvement-using-the-non-saccharomyces-lachancea-thermotolerans-and-hanseniasp",totalDownloads:89,totalDimensionsCites:0,doi:"10.5772/intechopen.100538",abstract:"Lachancea thermotolerans is a yeast species that works as a powerful bio tool capable of metabolizing grape sugars into lactic acid via lactate dehydrogenase enzymes. The enological impact is an increase in total acidity and a decrease in pH levels (sometimes >0.5 pH units) with a concomitant slight reduction in alcohol (0.2–0.4% vol.), which helps balance freshness in wines from warm areas. In addition, higher levels of molecular SO2 are favored, which helps to decrease SO2 total content and achieve better antioxidant and antimicrobial performance. The simultaneous use with some apiculate yeast species of the genus Hanseniaspora helps to improve the aromatic profile through the production of acetyl esters and, in some cases, terpenes, which makes the wine aroma more complex, enhancing floral and fruity scents and making more complex and fresh wines. Furthermore, many species of Hanseniaspora increase the structure of wines, thus improving their body and palatability. Ternary fermentations with Lachancea thermotolerans and Hanseniaspora spp. sequentially followed by Saccharomyces cerevisiae are a useful bio tool for producing fresher wines from neutral varieties in warm areas.",book:{id:"10901",title:"Grapes and Wine",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg"},signatures:"Antonio Morata, Carlos Escott, Iris Loira, Juan Manuel Del Fresno, Cristian Vaquero, María Antonia Bañuelos, Felipe Palomero, Carmen López and Carmen González"},{id:"78970",title:"Alternatives to CU Applications in Viticulture. How R&D Projects Can Provide Applied Solutions, Helping to Establish Legislation Limits",slug:"alternatives-to-cu-applications-in-viticulture-how-r-d-projects-can-provide-applied-solutions-helpin",totalDownloads:178,totalDimensionsCites:2,doi:"10.5772/intechopen.100500",abstract:"Copper (Cu) and its based preparations have been used for over 200 years to control fungi and bacterial diseases in cultivated plants. Downy mildew caused by the obligate biotrophic oomycete Plasmopara viticola is one of the most relevant and recurrent diseases of grapevines. Recently, the use of Cu is being limited by some regulations because of its high impact at different levels (health and environmental problems). Due to its accumulation in soil, this metal causes a little controversy with the principles of sustainable production. Therefore, international legislation and initiatives have recently been arisen to start limiting its use, with the main goal to replace it. In this framework, some alternatives have been tested and others are recently being developed to replace, at least partially, the use of Cu in viticulture. Many of them, are being developed and tested under the scope of research and development EU funded projects. To not compromise sustainability targets in viticulture, results from these R&D projects need to be considered to assess the present risks of using Cu in viticulture and to better support establishing limits for its applications, considering soils vulnerability, while no sustainable alternatives are available in the market.",book:{id:"10901",title:"Grapes and Wine",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg"},signatures:"Mario De La Fuente, David Fernández-Calviño, Bartosz Tylkowski, Josep M. Montornes, Magdalena Olkiewicz, Ruth Pereira, Anabela Cachada, Tito Caffi, Giorgia Fedele and Felicidad De Herralde"}],onlineFirstChaptersTotal:16},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo is a Professor at the Department of Engineering of the University of Naples “Parthenope”, Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino. Her research interests include multi-criteria decision analysis, industrial plant, logistics, manufacturing and safety. She serves as an Associate Editor for the International Journal of the Analytic Hierarchy Process. She is a member of AHP Academy and a member of several editorial boards. She has over 160 Scientific Publications in International Journals and Conferences and she is the author of 5 books on Innovation and Decision Making in Industrial Applications and Engineering.",institutionString:null,institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",isOpenForSubmission:!0,editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",isOpenForSubmission:!0,editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:'Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the "new normal". Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. 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He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}},{id:"351158",title:"Prof.",name:"David W.",middleName:null,surname:"Anderson",slug:"david-w.-anderson",fullName:"David W. Anderson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Calgary",country:{name:"Canada"}}}]}},subseries:{item:{id:"23",type:"subseries",title:"Computational Neuroscience",keywords:"Single-Neuron Modeling, Sensory Processing, Motor Control, Memory and Synaptic Pasticity, Attention, Identification, Categorization, Discrimination, Learning, Development, Axonal Patterning and Guidance, Neural Architecture, Behaviours and Dynamics of Networks, Cognition and the Neuroscientific Basis of Consciousness",scope:"Computational neuroscience focuses on biologically realistic abstractions and models validated and solved through computational simulations to understand principles for the development, structure, physiology, and ability of the nervous system. This topic is dedicated to biologically plausible descriptions and computational models - at various abstraction levels - of neurons and neural systems. This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. 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