\r\n\tIt has been established that energy/nutrient depletion, calcium flux injury, or oxidative stress disrupt endoplasmic reticulum homeostasis and even induce accumulation of misfolded/unfolded proteins leading to endoplasmic reticulum stress. Under endoplasmic reticulum stress conditions, an adaptive mechanism of coordinated signaling pathways, defined unfolded protein response (UPR), is activated to return the endoplasmic reticulum to its healthy functioning state. The aging causes a decrease of the protective adaptive response of the UPR and an increase of the pro-apoptotic pathway together with endoplasmic reticulum ultrastructural injury. Controlling endoplasmic reticulum stress response, maintaining the appropriate endoplasmic reticulum ultrastructure and homeostasis, and retaining mitochondria interplay are crucial aspects for cellular health.
\r\n
\r\n\tThis book presents a comprehensive overview of endoplasmic reticulum, including, but not limited to, endoplasmic reticulum ultrastructural anatomy, MAMs, endoplasmic reticulum stress, and their implication in health and diseases. Additionally, identifying perturbations in the endoplasmic reticulum stress response could lead to early detection of age-related disease and may help develop therapeutic approaches.
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1. Introduction
Visual information from the eyes generates vast amounts of data for the human brain to process, and provides us with unparalleled clarity and insight into the world we live in. Imaging with terahertz (THz) radiation is a research field that has gained a lot of interest and is in the process of moving from research laboratories to commercial applications [1, 2, 3, 4]. As such, the THz research field has grown so much that it has become impossible for a single human to be able to keep track of all developments [4]. Nevertheless, it is possible to outline why there is great interest and potential in THz imaging technology. Most non-conductive materials and non-polar liquids are THz transparent, useful for non-invasive inspection of many multi-component or buried systems, such as paintings [5], electronic circuits [6], space shuttle panels [7] and carbon-fiber composites [8]. Other possibilities are the measurement of picosecond processes in semiconductors [9], quality control of pharmaceutical tablets [10] and non-invasive detection of explosive substances [11]. A plethora of fundamental material resonances, such as phonons, rotations of molecules and precessions of spins, are observable and controllable by THz radiation [12]. Bio-medical applications are highly alluring most notably because the THz photon energies are non-ionizing and high-water sensitivity gives rise to label-free diagnosis of diseases that alter water content, such as cancer [13] and diabetic foot syndrome [14]. There is also the possibility of damaging or repairing DNA with intense THz radiation [15].
With so many possible applications, the reason why THz radiation is barely used outside of laboratories is due to costs of current THz technology. In particular to imaging, the technology is either too expensive, too slow or sacrifices some detection capability (such as picosecond temporal resolution). This is because materials which are suitable for efficient THz detection simply do not exist. This has resulted in THz detector arrays normally working in either narrowbands [16] or needing cryogenic temperatures for sensitive detection [17]. However, microbolometer arrays have very large bandwidths at room temperature operation [18] and when combined with digital holography they can measure both the amplitude and phase of THz radiation [19, 20]. Unfortunately bolometers achieve frequency resolution with a frequency selective source and they do not offer picosecond temporal resolution. This is acceptable for some applications such as detecting concealed weapons, however for applications where time gated detection is used, for example in extracting depths of painting coatings in original art works [5], it becomes unfeasible. An another imaging technique is to project a THz image on an electro-optic crystal then use visible light CCD arrays to spatially map-out the THz field incident onto the crystal [21, 22]. This does not sacrifice the temporal resolution offered time-domain THz spectrometers, however this needs a regen-amplified Ti:Sapphire laser which makes the whole system big and expensive and has prevented the widespread adoption of this technology despite its capabilities. These imaging techniques are all far-field, apart from [21], meaning that they fail to see detail below ∼500μm due to the THz wavelengths. There are near-field THz imaging techniques [23, 24, 25, 26, 27, 28, 29] which vary from placing AFM-tips next to the sample [23, 24, 25], to near-field THz-fiber probes [27] and even air-plasma has been used for sub-wavelength imaging [29]. A very impressive achievement is by M. Eisele, et al. [24] where they obtained 10 nm spatial resolution with 50 fs temporal resolution to reveal the time-dependence of photoexcitation in InAs nanowires.
The aforementioned imaging approaches are the standard imaging techniques, relying on a detector array or raster scanning, however there is another alternative. Namely, using a spatially modulated light beam and a single-pixel detector to obtain an image [30]. Approaches based on this technique are commonly called computational imaging because a computer is needed to recover the image although single-pixel imaging is another common name. The measurements are obtained sequentially as opposed to in parallel, like in detector arrays, hence this technology is usually slower. This can however be offset by the possibility of obtaining an N-pixel image using fewer measurements by employing techniques known as compressed sensing [30, 31]. The main advantage to this technology is that the use of a single-pixel detector greatly enhances the robustness of the system as well as reducing the complexity and cost. This is what makes them attractive for uses in THz-imaging: potential for fast imaging without increasing costs whilst being compatible with single-element detectors such as photoconductive antennas that can measure the amplitude and phase of a THz-pulse with 100 fs temporal resolution. In this chapter single-pixel imaging technologies for use with THz radiation are discussed, where in §2 we discuss the mathematical theory, §3 discusses the current state of the spatial light modulators for THz radiation with regards to the latest implementations of single-pixel THz cameras. §4 discusses where single-pixel THz cameras are likely to have an advantage over other competing THz technologies and the conclusions §5 summarize the whole chapter and ending with the authors’ view of the future development of THz single-pixel cameras.
2. Single-pixel imaging theory
Single-pixel imaging theory concerns itself with obtaining an image of a scene using a detector that can only measure the total amplitude emanating from the scene. The simplest idea is to raster scan an aperture across the field-of-view, building the image pixel by pixel. However, as the aperture is made smaller and smaller, the signal reaching our detector is reduced. We could increase the light incident onto our detector and overcome detector-noise by simultaneously scanning more apertures during each measurement, an idea that originates with Yates in 1935 [32]. In Figure 1(a) we show the main principle of this idea; we have a light beam that is spatially modulated which propagates through an object and onto a detector with no spatial resolution. It is of the utmost importance that in each measurement we know which apertures were open and which were closed. Without this information we could never reconstruct an image of the object. Each measurement is the dot product of the spatial encoding mask and the transmission function of the object, which is mathematically expressed as
Figure 1.
(a) Imaging with a single-element detector. An encoding mask spatially encodes a beam of radiation, then the beam passes through an object and onto the single-element detector. (b) Spatial encoding masks, where the first, second, third and fourth coloumns were constructed from Sylvester Hadamard, cyclic Hadamard, random and Fourier matrices respectively. The green triangle in the cyclic mask is there as a visual guide. (c) 2D image transform examples. Figure (a) was extracted from reference [33] under creative commons attribution 4.0 international license.
yi=∑j=1Naijxj,E1
where yi is our ith measurement, aij holds the spatial information of the ith mask and xj is the jth pixel of the object. The full set of measurements can be represented by the matrix equation
y=Ax,E2
where the rows of matrix A are shaped into the projected masks (ie. 1D vectors reshaped into 2D masks). Solving Eq. (2) for x is the cornerstone of single-pixel imaging. In the simpler cases A is an invertible matrix, meaning that x=A−1y is sufficient for us to the obtain our image. Alternatively we need to use least squares solvers or complex optimization problems [31], which are commonly used for undersampling procedures where one obtains an image with N pixels using fewer measurements.
A in Eq. (2) is called the basis expansion of our object x. For example, the most commonly know example is if A is the Fourier matrix, then y is the Fourier transform of our object x. This basis expansion determines the masks that will be projected in each measurement, and in 1(b) we show commonly used spatial encoding masks. Namely, masks constructed from a Sylvester-Hadamard, Cyclic-Hadamard, Random and Fourier matrices. Each one has its own advantages and disadvantages and these are briefly outlined.
The Sylvester-Hadamard matrices are binary, meaning that they are easily implemented, specifically with digital micromirror devices which are relatively cheap and have switch rates upto 20 kHz. The reconstruction technique can also be efficiently calculated by just doing the Fast Hadamard-Walsh transform, meaning one does not need to store A in memory that can be very large (ie. for an n×n image A would be a n2×n2 matrix). Further, if one implements the 2D transform of the Hadamard-Walsh transform with sequency ordering, then it has the effect of concentrating all the coefficients with large amplitudes around the (0, 0) pixel as can be seen in Figure 1(c). This is useful for undersampling procedures with the relevant masks obtained by transforming a series 2D-delta functions [34]. Finally, these are orthogonal matrices meaning they are very robust to detector noise [35]. A side note is that creating such masks at sub-THz wavelength resolutions can create grating diffraction effects as shown in § 5.3.2 of reference [33].
The Cyclic-Hadamard matrices, also known as Paley Type I and type II Hadamard matrices as they were first discovered by Paley in 1933 [36], are orthogonal and circulant matrices made of 1 s and -1 s. This means they have large noise robustness, easy binary implementation and they are constructed by having one vector, c, from which every row is created by cyclic permutations of this vector. For the spatial masks, this means that i+1 mask is obtained by shifting the i mask to left which can be seen in column two of Figure 1(b). This means that these masks are most commonly used as physically manufactured masks and can be placed on spinning discs. These matrices also have a fast-reconstruction technique which based on their circulant nature. Given an equation y=Cx where is a C is matrix constructed by cyclically shifting the top row c, then we can rewrite it as y=c⊛x with ⊛ being the circular convolution operator. Then by the circular convolution theorem Fy=Fc⊛x=FcFx, where F is the Fourier transform. This means that x=F−1Fy/Fc, thus if one uses the Fast Fourier Transform then the reconstruction algorithm is very efficient with a complexity of ONlogN for an N-pixel image.
Random masks constructed from Bernoulli matrices, or Gaussian random matrices, can also be made from 1 s and -1 s making for easy implementation using binary spatial light modulators. However, these matrices are not directly invertible and using a pseudo-inverse can create stability problems. Therefore convex minimization algorithms are usually used for image reconstruction [30, 31]. The main benefit of this masking approach is that is can be used for undersampling which can greatly reduce the total measurement time at the expense of complicated calculations. References [37, 38] were the first theoretical investigation and one can obtain their reconstruction scripts from reference [39], although reference [40] also freely provides their MATLAB scripts for another minimization algorithm called TVAL3 [41]. These algorithms can be slow, hence a mention needs to be given to reference [42] where Kowarlz et al. creates a pseudo-inverse matrix via Fourier-domain regularization that is able to recover images of quality similar to the slow minimazation algorithms, however with faster calculations based on matrix multiplication methods. Note, they also provide their MATLAB and Python scripts freely on github [43].
Fourier masks are those derived from the Fourier matrix. However, as this is just linear algebra representation of the Fourier transform and we are measuring real images (without imaginary numbers), then we do not need to measure the negative Fourier frequencies as they are just the complex conjugate of their positive frequency counterpart. The Fourier matrix is also orthogonal meaning it has noise robustness equal to the Hadamard matrices as well efficient image reconstruction algorithms, simply the Fast Fourier Transform. These masks, however, are not binary but require grayscale values which limits their deployability. Binary spatial modulators can accomplish this either by temporal dithering, at the expense of slower switch-rates, or by spatial dithering, which creates some quantization errors [34]. Nevertheless, these masks benefit from extensive literature based on the Fourier Transform and various image compression algorithms that can be reversed for image-undersampling procedures.
3. Spatially modulating THz radiation
In this single-pixel imaging modality, the most crucial part is to create a spatially modulated beam. In this respect for the THz regime there are four main methods that can be employed; by creating a physical mechanical mask, by changing the electrical conductivity of a material via the injection/depletion of charge carriers, by controlling the refractive index of liquid crystal cells and by creating a spatially varied beam directly at the THz generation stage.
3.1 Mechanical masks
Creating a physical mask to modulate THz radiation has the great advantage that this is the easiest in terms of manufacturing with great modulation depth, >99%, over very broadband frequency ranges. This is because most semiconductors and plastics are THz transparent whereas conductive metals absorb and reflect THz radiation [44]. Thus PCB manufacturing techniques can be used to create a set of spatial masks. This results in masks that need to be mechanically moved, however if placed on disc high switch-rates could be potentially achieved as discs can spin at high speeds. These techniques were used in references [45, 46].
There is another modulation technique that falls in this mechanical category. Namely, mirror arrays where each mirror can be individually addressed. Such arrays already exist for the visible light regime in the form of digital micromirror arrays (DMD). However, DMD mirrors are with dimensions around 10 μ m meaning their THz diffraction efficiency is incredibly low. Therefore larger mirrors were manufactured by reference [47]. This means they have good working efficiency and high contrast. Figure 2 shows their concept in parts (a-c) and their results in parts (d-f). The main problem with these devices is the mirrors have to physically move which creates some limits in regards to the switch rate, otherwise the metallic nature of the mirrors means they have a very broadband modulation frequencies.
Figure 2.
Schematic of a single pixel of the THz-SLM for normally incident terahertz waves. The pixel is composed of mirrors that are arranged in 4 rows and 8 columns. (a) OFF-state for a bias voltage of 0 V. all mirrors are inclined and incident terahertz radiation (red) is diffracted away (blue) from the transceiver. (b) ON-state for a bias voltage of 37 V. all mirrors are pulled down to the substrate and incident terahertz radiation (red) is reflected (blue) into the transceiver. (c) Schematic cross-sectional view of an unreleased mirror. The base of the mirror adheres to the parylene C, while the part to be released sits on the poly-Si. (d) Schematic cross-sectional view of a released mirror. The base of the mirror adheres to the parylene C, while the released part is inclined due to residual stress in the Cr-Cu-Cr mirror material. (e) Modulation contrast of the THz-SLM. The contrast exceeds a value of 0.5 for a working range from 0.97 THz to 2.28 THz with a maximum contrast of 0.87 at 1.38 THz. (f) Linear dependence of the detected modulated electric field on the number of switched-ON rows in the THz-SLM. (g) Linear dependence of the detected modulated electric field on the number of switched-ON columns in the THz-SLM. Figure reprinted from reference [47] under creative commons attribution 4.0 international license, with figures being relabelled and re-scaled.
3.2 THz modulation by charge carrier injection/depletion
The main principle with this THz modulation technique is based upon the Drude model dielectric function [48, 49].
εω=ε∞−ωp2ω2+iω/τs,E3
where τs is the carrier scattering time, ε∞ is frequency independent permittivity due to bound charges, and ωp=Ne2/meε0 is the plasma frequency of the material where N is the density of charge carriers with charge e, ε0 is the vacuum permittivity and me is the effective mass. When the incident wave frequency is higher than the plasma frequency, ω>ωp, the material has a dielectric response whereas for ω<ωp we have a metallic absorbing material response. Therefore, by controlling N we can change the plasma frequency of the material so the THz wave interacts with a dialectic or a metallic object. This is the main modulation principle of these devices. However, vanadium dioxide (VO 2) needs to be mentioned as it can undergo an insulator-to-metal phase transition via femtosecond optical excitation [50] or an electric field [51]. This material is placed here as using it as a THz modulator has identical experimental implementation, despite the fundamental physics being very different; namely THz modulation via electrical gating or optical excitation.
3.2.1 Optical modulators
Optical based spatial THz-light modulators are currently the best in terms of achieved switch-rate, operational frequency and ease of implementation. Their switch-rate and operational frequencies are both similar to the electrical modulators in that they also rely on modifying the charge carrier density in some material. However, as they use optical light to achieve this, their experimental implementation is very different and due to the current state of visible-light SLMs they are much easier to be implemented. One starts by patterning a visible light beam and then projecting this spatial pattern onto a semiconductor, thereby creating areas that experience large optical excitation and other areas which are left in their ground state. This in turn creates a spatially varying conductivity/absorption profile on the surface of the semiconductor, and thus if a THz beam passes through this surface then the inverse spatial pattern from the visible-light beam is imparted onto the THz beam. The optical excitation can come in two forms, pulsed and continuous wave. For both cases, the carrier concentration is described by
Nt=e−t/τl∫−∞tGt′et′/τldt′E4
for carrier generation rate Gt and excited carrier lifetime τl. Reference [52] developed a post-processing technique to account for the above equation, resulting in significantly improving image signal-to-noise when the masks are switched on timescales comparable to τl. However, it should be noted that their mathematical proposal is more general and is able to account for any other physical processes, relevant to the temporal response of the system, that can be described by mathematics.
For continuous wave excitation one needs to consider the photo-carrier generation, recombination and diffusion dynamics within the semiconductor. The steady-state equilibrium carrier concentration within the semiconductor is given by [48].
where I0 is the incident power per unit area, T is the Fresnel transmittance of the semiconductor, V is the volume where the photocarriers are in, ℏωe is the photon energy of the photo-excitation beam, and the factor of 2 accounts for the excitation of electrons and holes1. The modulation depth is going to be the difference between the ground-state carrier concentration and this new photomodulated concentration. In Eq. (5) it can be seen that large τl will give the greatest modulation depth, however this comes at the expense of switch-rate. This is seen in Figure 3(a), where we plot the carrier density from Eq. (4) for different carrier lifetimes. It can be seen that for the larger τl values the carrier density still has not reached its ground state value of 0, however they reach larger carrier densities hence this will result in larger THz modulation for the same photo-excitation powers. Hooper et al. experimentally studied the excitation powers needed for efficient THz modulation with regards to carrier lifetimes in reference [54]. Further, the physical resolution with which a pattern can imprinted on the THz beam is going to be either limited by the resolution with which we project our visible-light pattern or the carrier diffusion dynamics. In most cases, photomodulators with lifetimes around tens of microseconds are used hence the diffusion lengths are going be hundreds of microns, which is much higher than the limits imposed by the projection of visible light. There is a thorough theoretical study of carrier diffusion and modulation depth for THz spatial light modulators in reference [55].
Figure 3.
(a) Carrier density (in arbitrary units) for different carrier lifetimes, shown by the colored numbers in ms, as we switch a continuous wave source on and off. (b) Illustration of imaging setup: Using a digital micromirror device and a lens, a pump pulse is spatially structured and projected onto a silicon wafer. This spatially modulates a coincident THz pulse. This THz pulse then passes through an object and is measured on a single-element THz detector. Inset is an optical image of a resolution test target (cartwheel) manufactured from gold on a 6 μm thick silicon wafer. (c-e) THz images of the cartwheel shown in inset in part (b) taken through 400,110,6μm thick silicon wafers respectively. See supplementary fig. S4 for a close-up annotated version of part c. note, the cartwheels in a, b have diameters larger than the field of view. THz polarization is horizontal in experiment figures (b-e) adapted from reference [53]. The Optical Society (OSA) publishing group copyright with re-use permission granted by Rayko I. Stantchev.
For pulsed optical-excitation probed by a synchronous THz pulse, Eq. (5) changes because the THz pulse can travel through the spatially photopumped region a few picoseconds after photoexcitation and for τl>100ps then carrier recombination can be ignored2 however I0 then becomes power per pulse per unit area. Further, since the THz pulse can be set to arrive a few picoseconds after photoexictation, then the carrier diffusion lengths become very small (about 500 nm for silicon [53, 56]). This means that the fundamental resolution is set by the photoexicitation beam provided that one can access the THz near-fields before the THz beam has diffracted due to propagating through space. In practice, this means using ultra-thin photomodulators. Figure 3(b) show the setup of a study which shows how the THz image resolution is affected by the photomodulator thickness, with parts (c-e) showing the achieved resolution of 154, 100, 9 μm with silicon wafer thicknesses of 400, 110 and 6 μm achieving about λ/45 resolution. Recently Chen, et al. used an even thinner photomodulator, 180 nm thick vanadium dioxide, to obtain even better resolution at 4.5 mum at λ/100 [57].
3.2.2 Electrical modulators
Electrical based modulators are likely to be the long-term future solution for spatial THz modulators because they have very little fundamental limitations. Namely, the maximum switch-rates are limited by the carrier recombination rates meaning they can potentially achieve megahertz switch rates, provided the RC constants of the devices are taken into account, especially with electrically tunable materials such as graphene [58, 59]. Their size is determined by photolithographic manufacturing technologies, which is already orders of magnitudes smaller than the THz wavelengths meaning that pixel sizes can be highly subwavelength. In fact, sometimes THz modulation structures can be too large for some commercial photolithographic systems. They are fully self-contained and compact, which is their main advantage over the optical based modulators (see §3.2.1) that need a laser, a spatial visible-light modulator and a photomodulator. However, in the near-term future they are unlikely to be commercially available. This is because their modulation amplitudes are determined by how carriers are injected/depleted via electrical gating and this is yet to optimized.
One of the first demonstrations of this modulation technique was by Kleine-Ostmann et al. in 2004 [60] where they electronically depleted carriers from a GaAs/AlGaAs interface, achieving about 3% modulation across a broadband frequency range of 0.1 to 2 THz. Since then there have been numerous attempts at improving the modulation depth, see references [61, 62] for recent reviews. These efforts have included enhancing the interaction between the THz wave and the charge carrier regions by metamaterial structures [63, 64]. Others have recently used graphene as the modulator [65, 66]. Using metamaterials or Fabry-Perot type resonances to enhance the modulation depth has the trade-off of reducing the working frequencies of the modulator. A further note is that subwavelength grating structures can enhance the THz modulation over a broadband range [58] for the correct THz polarization.
In 2014 C. M. Watts et al. created an electrical based THz-SLM in reference [67], and Figure 4(a) shows their experimental schematic and part (b) shows an image of their SLM. They electrically change the THz absorption of a 2 μm thick layer of n-doped GaAs, with each individual pixel being addressed by a FPGA array. The authors study the noise in final images from raster, random and Hadamard masks. Some of their results can be seen in Figure 4(c) and (d) with part (e) showing their object. Note, they were able to obtain 8×8 images at 1frames-per-second with Figure 4(f) showing 5 frames of the object in part (e) moving across the field of view. The device itself does not have large modulation depths meaning it mostly serves as a powerful proof-of-concept device. Another study creating an electrical based THz-SLM used graphene to create a 4×4 electro spatial-modulator [68]. And at last but certainly not least, we have the 2020 contribution of Y. Malevich et al. [69] where they built a 16×16 SLM by electrically gating two graphene layers sandwiching an electrolyte. This device has broadband modulation depth and the electrolyte results in needing small voltages (below 4 V) meaning it can be easily integrated with microcontrollers. However the switch-rate, shown to be up-to 1 kHz, is limited by the generation of an electrical layer at the electrolyte-graphene interface, therefore more work is needed to optimize the modulation depth and switch rate. Nevertheless, these results [69] mark big progress towards a THz-SLM with a large number of pixels and low driving voltages.
Figure 4.
(a) Schematic of the single-pixel imaging process utilizing an SLM. An image is spatially modulated by the metamaterial and the resulting radiation is sent to the single-pixel detector. (b) Photograph of the SLM (courtesy of K. burke, Boston College media technology services); total active area of the SLM is (4.8 mm2). (c) Image reconstruction using 64 masks with each mask displayed for 22.4 ms, giving a total image acquisition time of 1.43 s. (d) Image reconstruction using FISTA and 45 masks with each mask displayed for 22.4 ms, giving a total image acquisition time of 1 s. the colourmap scale of each reconstruction was chosen to best display the data. (e) Photograph of the object studied. The object was scanned across the field of view at a speed of 1.8 mm/s. (f) Consecutive tiles show FISTA reconstruction using 45 Hadamard masks. Only the first five frames are shown in the figure (see supplementary section ‘compressive sensing’ for full movie: 10 frames). The approximate position of the cross aperture is shown in yellow as a guide to the eye. Figure adapted from reference [67]. Copyright nature publishing group with re-use permission granted by Willie J. Padilla.
3.3 Spatially patterned THz generation
Another innovative approach to single-pixel imaging is to create a spatially patterned beam at the generation step, rather than generate a homogeneous beam that is then spatially modulated, which has the benefit of not needing a THz-SLM. For the terahertz regime, this can be accomplished by three possible ways. First, having an array of photoconductive antennas [70, 71, 72], however this approach suffers from antenna cross-talk and inefficiency problems arising from the small working-area of the antennas whilst occupying a large area. Further, such antennas arrays have only been used as detectors. The second method is to use an electro-optic (EO) crystal that converts visible-light to THz frequencies via non-linear polarization effects [73]. The generation of THz radiation is localized to where the visible light is, hence projecting a spatially varying light beam will generate a THz-beam with the same spatial features. This idea was implemented by references [74, 75] where they used a used a SLM to pattern an 800 nm femtosecond pulse and project that onto a ZnTe crystal. The third method is similar to the second one, with the difference being the use of a spintronic THz emitter instead of an electro-optic crystal. Here the inverse spin Hall effect is used to generate an ultrafast current transient that generates the THz radiation [76, 77, 78]. The spatial patterning is again done by a visible-light SLM since the THz generation is again localized to areas where the optical-pump was shined upon. This was demonstrated by Chen et al. in reference [79].
The similarities between the spintronic and electro-optic crystal approaches are that they both require femtosecond pulses with mJ/cm2 powers and both measure the THz field-strength with sub-picosecond temporal resolution. The differences come from limitations imposed by the electro-optic crystals. First, absorption at the EO crystal phonons limits the working frequencies whereas spintronic emitters can emit from 1 to 30 THz [77], although organic EO crystals can significantly improve working bandwidth with commercial companies offering crystals emitting from 0.3 to 16 THz [80]. Second, EO crystals are typically thicker than the THz wavelengths for good working efficiency whereas spintronic emitters are nanometer thick allowing easier access to the THz near-fields for subwavelength resolution [79]. Finally, for the spintronic emitters the emitted THz polarization state is easily controlled by the externally applied magnetic field needed for THz emission [76], whereas for the EO crystal approach one needs to add an additional visible light SLM [81] resulting in increased system complexity.
Figure 5(a) shows the experimental setup of reference [79] which uses the spintronic emitter array approach. Note that the EO crystal approach is identical in that you only have to replace the spintronic emitter with the EO crystal and remove the magnetic field, then place the object as close as possible to the emitter array. One should note that the use of the second DMD in Figure 5(a) is only to correct the phase front induced by first DMD, which can also be achieved by the technique shown in the supplementary information of reference [82]. The spintronic emitter is nanometer thick hence Chen et al. was able to resolve metallic lines 6 μm in width, as shown in Figure 5(c)–(g), which is significantly shorter than the THz wavelengths. Note, at these subwavelength scales polarization effects become significant as be seen when comparing Figure 5(d) and (e) where they show images with horizontal and vertical polarization, respectively, of the same object.
Figure 5.
(a) Schematic of the GHOSTEAM system. The spintronic THz emitter array (STEA) is excited by two-DMD-encoded fs laser pulses and generates spatially coded THz pulses. An object “CAEP” was placed in the near-field region (z<<λ). The illuminating THz pulse was collected and sent to a single-pixel detector. (b) Schematic of the STEA, consisting of a W(2 nm)/Fe(2 nm)/Pt(2 nm) trilayer heterostructure and working in the binary emission state with polarization perpendicular to applied magnetic field. (c) Optical image of an object with a field of view of FOV 1 = 834 μm 834μm. the bright regions are gold attached on the 150-nm-thick protective SiO2 layer on top of the STEA. THz ghost images in FOV 1 with a magnetic field (green arrows) applied along the vertical direction (d) and horizontal direction (e). The pixel size and scale bar are 13.0 μm and 100μm, respectively, for both images. (f) THz ghost image in FOV 2 (indicated by the black dashed box in c) with a pixel size of 6.5 μm and a scale bar of 50 μm. the applied magnetic field B is along the horizontal direction (indicated by the green arrow), and the polarization of the THz radiation (indicated by the white double-headed arrow) is perpendicular to B. (g) Averaged amplitude of the THz field along the black dashed arrow in (f). Figure adapted and relabelled from reference [79]. Copyright nature publishing group with re-use permission under creative commons attribution 4.0 international license.
3.4 Liquid crystal THz modulators
Liquid crystal modulators work by the re-orientating the material molecules under an applied voltage. As the molecules are oblong, this changes the refractive index that an electro-magnetic wave experiences. Therefore these devices are great for phase modulation giving the greatest freedom in the values that the sampling matrix can take. In other words, they can theoretically project a Fourier matrix that has grayscale complex-values. Note that complex valued masks can be used in conjunction with an intensity only detector to obtain an image that has phase and amplitude information [83]. A liquid crystal based SLM for THz was computationally studied [84]. However, the re-orientation of the molecules is a slow process, and in the visible light regime liquid crystal displays are typically limited to below 100 Hz switch rates. Due to the longer THz wavelengths, thicker layers of liquid crystals are needed resulting in even slower switch rates. For this reason, liquid crystal spatial modulators for THz radiation have been limited mostly to applications where slow switching speeds are acceptable such as dynamically controllable lenses [85, 86], absorption [87] or polarization control [88].
4. Applications and discussion
The first demonstration of a single-pixel THz camera that uses a multi-pixel modulation approach3 was in 2008 by Chan et al. [89]. Therein the authors showed amplitude and phase imaging was possible. Since Chan showed single-pixel THz imaging with metallic masks [89], most publications up until now have focused on improving the implementation by showing proof-of-concept modulation/generation techniques as opposed to potential applications. Shortly after in 2009 spectroscopic imaging was demonstrated [90]. The next experiment was in 2012 by Shen et al. [46] where they used a spinning disc with random masks, but it should be noted that their experiment used an infrared and a THz source whilst using the same SLM. The first demonstration of an optical based SLM was by Shrekenhamer et al. in 2013 [49]. The same group then published an electrical based SLM for single-pixel THz imaging in 2014 [67]. The next developments showed in 2016 that such imaging systems can detect a sub-wavelength fissure (8 μm) in a circuit board hidden by silicon [56]. Other applications show that these single-pixel cameras can be used for near-field biological imaging [91, 92], sub-wavelength THz mapping of graphene photoconductivity [82] as well as 2D tomographic imaging [93]. Further, observing hydration changes in a leaf due to intense light exposure over a 15 minute period has also been demonstrated [52]. Other recent studies include demonstrating a spinning disc system working from 3 to 13 THz using random masks [45]. Reference [94] shows how random, Hadamard and masks based on the discrete cosine transform perform in the THz regime and reference [95] studied Hadamard vs. Fourier masks in the context of undersampling performance.
The potential applications and capabilities of single-pixel THz cameras are directly determined by the THz source and detector, rather than the technique used to impart a spatial pattern in a beam of THz radiation. As such, it is unlikely for there to be a single-solution for all practical applications. Therefore, it is valuable to discuss where each of the techniques in §3 are likely to be used and how they compare to other THz imaging techniques. Metamaterial based SLMs, or specifically those that work over a few select frequencies, are unlikely to become widespread. This is because if you want to take an image only at one THz frequency then you can just use a bolometer detector array [18] and combine it with digital holography [19, 20] for an amplitude and phase measurement. Single-pixel imaging technologies are hampered by the serial data acquisition process, as such they will never truly compete at fast imaging rates with the parallel-data acquisition of detector arrays. As mentioned earlier, they compete in terms of being applicable when a detector array with the desired capabilities is just infeasible. This for THz technology translates itself to time-gated detection techniques that measure the amplitude and phase of a THz pulse with sub-picosecond temporal resolution, for example photo-conductive antennas [73].
The metallic/physical based masks, employed in §3.1, have contrast ratios of ∼99% over very large working frequencies. For example, holes in an aluminum plate could be used as an SLM for visible light as well for sub-THz frequencies and everything in between including ultrasound beams. The upper frequency limit is set by the plasma frequency whereas the lower frequency limit is set by the penetration depth at GHz frequencies. The major drawback is the physical movement involved in changing the masks. Using dynamically controlled mirrors, such those in Figure 2, requires no physical movement however their diffraction efficiency at low frequencies needs to be considered before implementation. Otherwise, their frequency response is going to be again to be determined by the reflection of a metal hence it is very broad. Such SLMs are probably most compatible for THz spectrometers that can measure between 1 and 30 THz [45], such as those based on air-plasma [96], spintronic [77] and organic EO crystals [80] emission techniques. This is of course compared to conductivity based SLMs of §3.2.
Modifying the Drude plasma frequency of a semiconductor via injection/depletion of charge carriers has great potential for compact integration of the entire imaging system, as long as electrical gating is used as it negates the need for an extra pump-laser. The drawback is that to ensure modulation depth over a large frequency range the Drude plasma frequency has to be sufficiently modified. For example, after photoexcitation of silicon if ωp moves from 0.01 THz to 25 THz, then the modulation depth for frequencies above 20 THz is going to be very poor. However, if the measurement only needs to measure frequencies between 0.1 and 2 THz with 100 fs temporal resolution, the working frequencies of many commercial THz-TDS systems, then this plasma frequency is going to be fine. For example, reference [52] achieved a 32×32 THz video with 6 frames-per-second using a system with such measurement capabilities. Their SLM is an optical excitation one, hence their system is not as compact as that shown in Figure 4 but it demonstrates that fast THz imaging with single-pixel cameras is possible. Nevertheless, Chen et al. showed a THz amplitude modulation of near 200%4 over the frequency range of 0.1 to 2 THz using electrical gating of graphene [59]. This shows electrical modulators have great potential but they are far from being commercially available as it was only in 2020 that a demonstration of 16×16 THz modulator was published [69], which has lower modulation depth and slower switch-rate than reference [52]. Finally, the physical resolution of these approaches is ultimately limited by the visible light pattern or the manufacturing technology used to make the array. As such, electrical modulators are capable of reaching resolutions of 150 nm and then not have issues of misalignment. In terms of sheer resolution, however, they are unlikely to compete with the 10 nm resolution achieved with AFM-tips [24] although due to the multiple scatterers and apertures in each measurement they will have larger SNRs [56] and thus offer quicker acquisition. A side note is that using Hadamard-Sylvester masks at sub-wavelength resolutions can result in grating-like diffraction effects for individual masks as shown in chapter 5.3.2 of reference [33].
Direct generation of a spatially varying THz beam, §3.3, has the benefit of not needing a THz-SLM at all, reducing the system complexity, whilst having visible light resolution. However, all the current techniques demonstrated have one major drawback: they need pulse energies around 1 mJ/cm2 for sufficient signal-to-noise. A back of the envelope calculation shows that if such fluences are needed over a 500×500μm square, then average laser powers of 2.5 mW, 0.625 W and 125 W incident onto the emitter area would be needed if the laser repetition rates are 1 kHz, 250 kHz and 50 MHz respectively5. The lower repetition rate lasers have lower signal-to-noise (measuring less pulses per unit time) and usually have larger laser noise-fluctuations causing further degradation. As such, these techniques are likely only usable for areas smaller than 500×500μm where accessing the THz near-fields is necessary. Their competing technology is mapping out the THz fields onto a EO crystal using a CCD camera [21], which can achieve near-field resolution and still measure the THz-fields with sub-picosecond temporal resolution. Theoretically, neither the technique of reference [21] and that shown in Figure 5 have an edge over of the other. However, in terms of experimental implementation the spintronic emitter array [79] has some advantages. Namely, easily controllable polarization and you need a high-quality camera for the EO-mapping approach [21] wheres as DMDs are low cost and found in everyday projectors. Finally, the EO-mapping approach needs an ultra-thin EO crystal thereby necessitating the use of an intense THz-source, whereas the spintronic array could possibly be implemented with a 100 kHz laser which should improve the SNR.
5. Conclusions
Although the first experimental implementations of single-pixel cameras can be traced back to 1976 [97], such imaging approaches were not widely studied or implemented in the commercial world. The reason is that the serial measurement of such ideas can not compete with parallel data acquisition of imaging arrays. Further, compressed sensing techniques began gaining mainstream attention in 2006 after two publications [37, 38]. This coincides with the development of visible light spatial modulators thereby allowing the implementation of the ideas in references [37, 38]. Whilst inherently slower than imaging arrays, these single-pixel cameras are much more robust and easier to implement in areas where imaging array technology is unavailable. In particular, the terahertz frequency regime.
This book chapter began by outlining the current state of THz cameras. Then it discusses the background theory of single-pixel imaging techniques. Most of the chapter was dedicated to discussing the current state of spatial THz-light modulators for use in single-pixel THz imaging in §3. The modulation techniques discussed are based on mechanical masks §3.1, optical §3.2.1 and electrical §3.2.2 modulation of conductivity, direct generation of spatially varying THz beams §3.3 and liquid crystal modulators §3.4. The final §4 is a discussion of the current state of single-pixel cameras as well the pros and cons of each different THz-SLM methodology.
The most advanced THz-SLM at present are those based on optical excitation of semiconductors, §3.2.1, however this is mostly because of their ease of implementation with current technology. Electrical modulators, §3.2.2, are likely to become the most used in the long term because compared to optical modulators they offer the same potential switch-speeds if not quicker, the same working frequencies, they are more compact and the physical resolution is limited by photolithrographic technology as opposed to visible light resolution. Further, the physical resolution been limited by the diffraction of the visible light-pump in an optical SLM is only achievable with high-power low-rep rate lasers, whereas electrical modulators would be compatible with fiber-based THz systems, that have magnitudes higher SNRs and are much cheaper, whilst maintaining the same resolution. Generating a THz beam with spatial variations has great resolution set by the visible-light diffraction limit, however their appeal will significantly drop the moment someone builds an electrical-based THz modulator with say 500×500 nm sized array elements that can be placed in the near-field of an object. Mechanical masks are mostly likely to be used in some niche applications that for example require simultaneous imaging with a THz beam and an ultrasonic beam. Liquid crystal modulators are unlikely to be used in single-pixel imaging unless there is a breakthrough that allows their switch-rates to reach 10 kHz, although they offer the most freedom in regards to the values of the projected masks (ie. complex grayscale values).
Ultimately, the development of single-pixel THz cameras is likely to proceed with optical modulators being used in university laboratories to optimize the algorithms and methodologies used in image recovery as well as synchronization of all the equipment. Simultaneously there will be an effort to develop electrical based array modulators that have fast-switch rates and large modulation depth over a broadband frequency range. Then the miniaturization of such modulator arrays will start and it is likely that at this point such commercially available THz-SLMs will become available from new specialized start-up companies. Spatially-generated THz beams will likely remain only in laboratories for fundamental studies of different systems, but are unlikely to be used for industrial and commercial applications mostly due to the requirement of pump powers of ∼1 mJ/cm2. Further, they are compatible with time-gated synchronization of visible-pump THz-probe experiments allowing the study of sub-picosecond photoexcitation dynamics, hence their appeal to university labs.
Acknowledgments
This work was partially supported by the Research Grants Council of Hong Kong (project numbers 14206717 and 14201415), The Hong Kong Innovation and Technology Fund (project number ITS/371/16), The Engineering and Physical Sciences Research Council (grant number EP/S021442/1), and the Royal Society Wolfson Merit Award (EPM).
Conflict of interest
The authors declare no conflict of interest.
Nomenclature
AFM
Atomic force microscope
PCB
Printed Circuit Board
FPGA
Field-programmable gate array
SLM
Spatial light modulator
THz
Terahertz
EO
Electro-optic
SNR
Signa-to-noise ratio
DMD
Digital micromirror device
VO2
Vanadium Dioxide
CCD
Charge Coupled device
\n',keywords:"spatial light modulator, single pixel camera, compressed sensing, Hadamard imaging, terahertz time-domain spectrometer, single-element detectors, sub-wavelength resolution",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/75638.pdf",chapterXML:"https://mts.intechopen.com/source/xml/75638.xml",downloadPdfUrl:"/chapter/pdf-download/75638",previewPdfUrl:"/chapter/pdf-preview/75638",totalDownloads:368,totalViews:0,totalCrossrefCites:0,dateSubmitted:"October 16th 2020",dateReviewed:"February 17th 2021",datePrePublished:"March 22nd 2021",datePublished:null,dateFinished:"March 10th 2021",readingETA:"0",abstract:"Terahertz imaging looks set to become an integral part of future applications from semiconductor quality control to medical diagnosis. This will only become a reality when the technology is sufficiently cheap and capabilities adequate to compete with others. Single-pixel cameras use a spatial light modulator and a detector with no spatial-resolution in their imaging process. The spatial-modulator is key as it imparts a series of encoding masks on the beam and the detector measures the dot product of each mask and the object, thereby allowing computers to recover an image via post-processing. They are inherently slower than parallel-pixel imaging arrays although they are more robust and cheaper, hence are highly applicable to the terahertz regime. This chapter dedicates itself to terahertz single-pixel cameras; their current implementations, future directions and how they compare to other terahertz imaging techniques. We start by outlining the competing imaging techniques, then we discuss the theory behind single-pixel imaging; the main section shows the methods of spatially modulating a terahertz beam; and finally there is a discussion about the future limits of such cameras and the concluding remarks express the authors’ vision for the future of single-pixel THz cameras.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/75638",risUrl:"/chapter/ris/75638",signatures:"Rayko Ivanov Stantchev and Emma Pickwell-MacPherson",book:{id:"10206",type:"book",title:"Terahertz Technology",subtitle:null,fullTitle:"Terahertz Technology",slug:null,publishedDate:null,bookSignature:"Dr. Borwen You and Dr. Ja-Yu Lu",coverURL:"https://cdn.intechopen.com/books/images_new/10206.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83962-684-5",printIsbn:"978-1-83962-612-8",pdfIsbn:"978-1-83962-685-2",isAvailableForWebshopOrdering:!0,editors:[{id:"191131",title:"Dr.",name:"Borwen",middleName:null,surname:"You",slug:"borwen-you",fullName:"Borwen You"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Single-pixel imaging theory",level:"1"},{id:"sec_3",title:"3. Spatially modulating THz radiation",level:"1"},{id:"sec_3_2",title:"3.1 Mechanical masks",level:"2"},{id:"sec_4_2",title:"3.2 THz modulation by charge carrier injection/depletion",level:"2"},{id:"sec_4_3",title:"3.2.1 Optical modulators",level:"3"},{id:"sec_5_3",title:"3.2.2 Electrical modulators",level:"3"},{id:"sec_7_2",title:"3.3 Spatially patterned THz generation",level:"2"},{id:"sec_8_2",title:"3.4 Liquid crystal THz modulators",level:"2"},{id:"sec_10",title:"4. Applications and discussion",level:"1"},{id:"sec_11",title:"5. Conclusions",level:"1"},{id:"sec_12",title:"Acknowledgments",level:"1"},{id:"sec_15",title:"Conflict of interest",level:"1"},{id:"sec_12",title:"Nomenclature",level:"1"}],chapterReferences:[{id:"B1",body:'Mittleman, D. M. Twenty years of terahertz imaging [Invited]. Optics Express DOI: 10.1364/oe.26.009417 (2018).'},{id:"B2",body:'Chan, W. 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Applied Optics DOI: 10.1364/ao.15.000107 (1976).'}],footnotes:[{id:"fn1",explanation:"This assumes that the photogenerated holes and electrons have similar properties such carrier mobility, effective mass, lifetime,... ie. a hole and an electron absorb the same amount of terahertz."},{id:"fn2",explanation:"This is also assumes that the pulse repetition period is much longer than the carrier lifetime, ie. the carriers have relaxed back to their ground state by the time the next pulse arrives."},{id:"fn3",explanation:"Technically, a raster scanner is a single-pixel camera. However this chapter concerns itself when the beam of radiation has multiple scatters and apertures in each measurement. Therefore raster scanners are excluded."},{id:"fn4",explanation:"This is was done by changing the reflection coefficient from 1 to −1 near the Brewster angle."},{id:"fn5",explanation:"Losses from various optical elements would occur and hence higher laser powers will be needed initially."}],contributors:[{corresp:null,contributorFullName:"Rayko Ivanov Stantchev",address:null,affiliation:'
Department of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong SAR
Department of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong SAR
Physics Department, Warwick University, UK
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IntechOpen chapters and articles are distributed under CC BY 3.0 licences allowing users to “copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship...” and there is no non-commercial restriction.
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This chapter provides a brief history of VR and AR in medicine, as well as the principles and standards of their function. Finally, the studies that show the effect of the implementation of these methods in different fields of medical training are summarized and presented.",book:{id:"6211",slug:"medical-and-surgical-education-past-present-and-future",title:"Medical and Surgical Education",fullTitle:"Medical and Surgical Education - Past, Present and Future"},signatures:"Panteleimon Pantelidis, Angeliki Chorti, Ioanna Papagiouvanni,\nGeorgios Paparoidamis, Christos Drosos, Thrasyvoulos\nPanagiotakopoulos, Georgios Lales and Michail Sideris",authors:[{id:"211650",title:"M.D.",name:"Panteleimon",middleName:null,surname:"Pantelidis",slug:"panteleimon-pantelidis",fullName:"Panteleimon Pantelidis"},{id:"211654",title:"Ms.",name:"Angeliki",middleName:null,surname:"Chorti",slug:"angeliki-chorti",fullName:"Angeliki Chorti"},{id:"220557",title:"Ms.",name:"Ioanna",middleName:null,surname:"Papagiouvanni",slug:"ioanna-papagiouvanni",fullName:"Ioanna Papagiouvanni"},{id:"220558",title:"Mr.",name:"Georgios",middleName:null,surname:"Paparoidamis",slug:"georgios-paparoidamis",fullName:"Georgios Paparoidamis"},{id:"220559",title:"Mr.",name:"Georgios",middleName:null,surname:"Lales",slug:"georgios-lales",fullName:"Georgios Lales"},{id:"220560",title:"Mr.",name:"Thrasyvoulos",middleName:null,surname:"Panagiotakopoulos",slug:"thrasyvoulos-panagiotakopoulos",fullName:"Thrasyvoulos Panagiotakopoulos"},{id:"220561",title:"Mr.",name:"Christos",middleName:null,surname:"Drosos",slug:"christos-drosos",fullName:"Christos Drosos"},{id:"220562",title:"Dr.",name:"Michail",middleName:null,surname:"Sideris",slug:"michail-sideris",fullName:"Michail Sideris"}]},{id:"50915",doi:"10.5772/63266",title:"Doped Bioactive Glass Materials in Bone Regeneration",slug:"doped-bioactive-glass-materials-in-bone-regeneration",totalDownloads:3485,totalCrossrefCites:13,totalDimensionsCites:34,abstract:"In the arena of orthopaedic surgery, autograft is considered to be the gold standard for correction of fracture repair or other bone pathologies. But, it has some limitations such as donor site morbidity and shortage of supply, which evolved the use of allograft that also has some disadvantages such as immunogenic response to the host, low osteogenicity as well as possibilities of disease transmission. Despite the benefits of autografts and allografts, the limitations of each have necessitated the pursuit of alternatives biomaterials that has the ability to initiate osteogenesis, and the graft should closely mimic the natural bone along with regeneration of fibroblasts. A variety of artificial materials such as demineralised bone matrix, coralline hydroxyapatite and calcium phosphate-based ceramics such as hydroxyapatite (HA), β-tricalcium phosphate (β-TCP) and bioactive glass have been used over the decades to fill bone defects almost without associated soft tissue development. Most of them were having only the properties of osteointegration and osteoconduction. Only bioactive glass possesses osteogenic property that stimulates proliferation and differentiation of osteoprogenitor cells and in some cases influencing the fibroblastic properties. But, this material has also some disadvantages such as short-term and low mechanical strength along with decreased fracture resistance; but, this was further minimised by ion doping that positively enhanced new bone formation. There are many metal ions such as magnesium (Mg), strontium (Sr), manganese (Mn), iron (Fe), zinc (Zn), silver (Ag) and some rare earths that have been doped successfully into bioactive glass to enhance their mechanical and biological properties. In some of the cases, mesoporous bioactive glass materials with or without such doping have also been employed (with homogeneous distribution of pores in the size ranging between 2 and 50 nm). These biomaterials can be served as scaffold for bone regeneration with adequate mechanical properties to restore bone defects and facilitate healing process by regeneration of soft tissues as well. This chapter encompasses the use of bioactive glass in bulk and mesoporous form with doped therapeutic ions, their role in bone tissue regeneration, use as delivery of growth factors as well as coating material for orthopaedic implants.",book:{id:"5164",slug:"advanced-techniques-in-bone-regeneration",title:"Advanced Techniques in Bone Regeneration",fullTitle:"Advanced Techniques in Bone Regeneration"},signatures:"Samit Kumar Nandi, Arnab Mahato, Biswanath Kundu and Prasenjit\nMukherjee",authors:[{id:"60514",title:"Dr.",name:"Samit",middleName:null,surname:"Nandi",slug:"samit-nandi",fullName:"Samit Nandi"}]},{id:"37120",doi:"10.5772/29607",title:"Trigeminocardiac Reflex in Neurosurgery - Current Knowledge and Prospects",slug:"the-trigeminocardiac-reflex-in-neurosurgery-current-knowledge-and-prospects",totalDownloads:3425,totalCrossrefCites:10,totalDimensionsCites:27,abstract:null,book:{id:"749",slug:"explicative-cases-of-controversial-issues-in-neurosurgery",title:"Explicative Cases of Controversial Issues in Neurosurgery",fullTitle:"Explicative Cases of Controversial Issues in Neurosurgery"},signatures:"Amr Abdulazim, Martin N. Stienen, Pooyan Sadr-Eshkevari, Nora Prochnow, Nora Sandu, Benham Bohluli and Bernhard Schaller",authors:[{id:"78171",title:"Prof.",name:"Bernhard",middleName:null,surname:"Schaller",slug:"bernhard-schaller",fullName:"Bernhard Schaller"},{id:"78525",title:"Mr.",name:"Amr",middleName:null,surname:"Abdulazim",slug:"amr-abdulazim",fullName:"Amr Abdulazim"},{id:"78530",title:"Dr",name:"Pooyan",middleName:null,surname:"Sadr-Eshkevari",slug:"pooyan-sadr-eshkevari",fullName:"Pooyan Sadr-Eshkevari"},{id:"126039",title:"Dr.",name:"Martin",middleName:"Nikolaus",surname:"Stienen",slug:"martin-stienen",fullName:"Martin Stienen"},{id:"126040",title:"Dr.",name:"Nora",middleName:null,surname:"Prochnow",slug:"nora-prochnow",fullName:"Nora Prochnow"},{id:"126041",title:"Dr.",name:"Benham",middleName:null,surname:"Bohluli",slug:"benham-bohluli",fullName:"Benham Bohluli"}]},{id:"26559",doi:"10.5772/28833",title:"Local Antibiotic Therapy in the Treatment of Bone and Soft Tissue Infections",slug:"local-antibiotic-therapy-in-the-treatment-of-bone-and-soft-tissue-infections",totalDownloads:6554,totalCrossrefCites:5,totalDimensionsCites:21,abstract:null,book:{id:"784",slug:"selected-topics-in-plastic-reconstructive-surgery",title:"Selected Topics in Plastic Reconstructive Surgery",fullTitle:"Selected Topics in Plastic Reconstructive Surgery"},signatures:"Stefanos Tsourvakas",authors:[{id:"75532",title:"Dr.",name:"Stefanos",middleName:null,surname:"Tsourvakas",slug:"stefanos-tsourvakas",fullName:"Stefanos Tsourvakas"}]}],mostDownloadedChaptersLast30Days:[{id:"65467",title:"Anesthesia Management for Large-Volume Liposuction",slug:"anesthesia-management-for-large-volume-liposuction",totalDownloads:5965,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The apparent easiness with which liposuction is performed favors that patients, young surgeons, and anesthesiologists without experience in this field ignore the many events that occur during this procedure. Liposuction is a procedure to improve the body contour and not a surgery to reduce weight, although recently people who have failed in their plans to lose weight look at liposuction as a means to contour their body figure. Tumescent liposuction of large volumes requires a meticulous selection of each patient; their preoperative evaluation and perioperative management are essential to obtain the expected results. The various techniques of general anesthesia are the most recommended and should be monitored in the usual way, as well as monitoring the total doses of infiltrated local anesthetics to avoid systemic toxicity. The management of intravenous fluids is controversial, but the current trend is the restricted use of hydrosaline solutions. The most feared complications are deep vein thrombosis, pulmonary thromboembolism, fat embolism, lung edema, hypothermia, infections and even death. The adherence to the management guidelines and prophylaxis of venous thrombosis/thromboembolism is mandatory.",book:{id:"6221",slug:"anesthesia-topics-for-plastic-and-reconstructive-surgery",title:"Anesthesia Topics for Plastic and Reconstructive Surgery",fullTitle:"Anesthesia Topics for Plastic and Reconstructive Surgery"},signatures:"Sergio Granados-Tinajero, Carlos Buenrostro-Vásquez, Cecilia\nCárdenas-Maytorena and Marcela Contreras-López",authors:[{id:"273532",title:"Dr.",name:"Sergio Octavio",middleName:null,surname:"Granados Tinajero",slug:"sergio-octavio-granados-tinajero",fullName:"Sergio Octavio Granados Tinajero"}]},{id:"42855",title:"Critical Care Issues After Major Hepatic Surgery",slug:"critical-care-issues-after-major-hepatic-surgery",totalDownloads:8909,totalCrossrefCites:2,totalDimensionsCites:2,abstract:null,book:{id:"3164",slug:"hepatic-surgery",title:"Hepatic Surgery",fullTitle:"Hepatic Surgery"},signatures:"Ashok Thorat and Wei-Chen Lee",authors:[{id:"52360",title:"Prof.",name:"Wei-Chen",middleName:null,surname:"Lee",slug:"wei-chen-lee",fullName:"Wei-Chen Lee"},{id:"157213",title:"Dr.",name:"Ashok",middleName:null,surname:"Thorat",slug:"ashok-thorat",fullName:"Ashok Thorat"}]},{id:"72175",title:"Fontan Operation: A Comprehensive Review",slug:"fontan-operation-a-comprehensive-review",totalDownloads:1252,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Since the first description of the Fontan operation in the early 1970s, a number of modifications have been introduced and currently staged, total cavopulmonary connection with fenestration has become the most commonly used multistage surgery in diverting the vena caval blood flow into the lungs. The existing ventricle, whether it is left or right, is utilized to supply systemic circuit. During Stage I, palliative surgery is performed, usually at presentation in the neonatal period/early infancy, on the basis of pathophysiology of the cardiac defect. During Stage II, a bidirectional Glenn procedure is undertaken in which the superior vena caval flow is diverted into the lungs at an approximate age of 6 months. During Stage IIIA, the blood flow from the inferior vena cava (IVC) is rerouted into the pulmonary arteries, typically by an extra-cardiac conduit along with a fenestration, generally around 2 years of age. During Stage IIIB, the fenestration is closed by transcatheter methodology 6–12 months after Stage IIIA. The evolution of Fontan concepts, the indications for Fontan surgery, and the results of old and current types of Fontan operation form the focus of this review.",book:{id:"9585",slug:"advances-in-complex-valvular-disease",title:"Advances in Complex Valvular Disease",fullTitle:"Advances in Complex Valvular Disease"},signatures:"P. Syamasundar Rao",authors:[{id:"68531",title:"Dr.",name:"P. Syamasundar",middleName:null,surname:"Rao",slug:"p.-syamasundar-rao",fullName:"P. 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Interventions meant to correct these conditions are commonly based on symmetrical models of appearance and do not take into account asymmetric organ weight distribution, asymmetries of respiratory mechanics, and dominant movement patterns that are reinforced in daily functional activities. A model of innate, human asymmetry derived from the theoretical framework of the Postural Restoration Institute® (PRI) explicitly describes the physiological, biomechanical, and respiratory components of human asymmetry. This model is important because it gives an accurate baseline for understanding predisposing factors for the development of postural disorders, which, without intervention, will likely progress to structural dysfunction. Clinical tests to evaluate tri-planar musculoskeletal relationships and function, developed by PRI, are based on this asymmetric model. These tests are valuable for assessing patient’s status in the context of human asymmetry and in guiding appropriate exercise prescription and progression. Balancing musculoskeletal asymmetry is the aim of PRI treatment. Restoration of relative balance decreases pain, restores improved alignment, and strengthens appropriate muscle function. It can also halt the progression of dysfunction and improve respiration, quality of life, and appearance. PRI’s extensive body of targeted exercise progressions are highly effective due to their basis in the tri-planar asymmetric human model.",book:{id:"5816",slug:"innovations-in-spinal-deformities-and-postural-disorders",title:"Innovations in Spinal Deformities and Postural Disorders",fullTitle:"Innovations in Spinal Deformities and Postural Disorders"},signatures:"Susan Henning, Lisa C. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
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\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
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\r\n\t
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
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Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"18",type:"subseries",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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Dr. Şentürk currently works as an professor of Biochemistry in the Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Ağri Ibrahim Cecen University, Turkey. \nDr. Şentürk published over 120 scientific papers, reviews, and book chapters and presented several conferences to scientists. \nHis research interests span enzyme inhibitor or activator, protein expression, purification and characterization, drug design and synthesis, toxicology, and pharmacology. \nHis research work has focused on neurodegenerative diseases and cancer treatment. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:320,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/6141",hash:"",query:{},params:{id:"6141"},fullPath:"/chapters/6141",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()