Regional Lactic Acid-Fermented Specialties in the Philippines
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5457",leadTitle:null,fullTitle:"Contemporary Leadership Challenges",title:"Contemporary Leadership Challenges",subtitle:null,reviewType:"peer-reviewed",abstract:"Social and behavioral science has for decades studied and recognized leadership as a social exchange between leaders and followers. But leadership is rather complex, and as such, it tends to lead to an increased interest within and across different disciplines. This book is an attempt to provide theoretical and empirical framework to better understand leadership challenges in various contexts. The authors cover an array of themes that span from an individual level to an organizational and societal level. In this volume, two sections are presented. The first section based on individual level focuses on different leadership styles and abilities, and the other section provides theories to understand leadership in public administration, in industrial settings and in nonprofit organizations.",isbn:"978-953-51-2904-2",printIsbn:"978-953-51-2903-5",pdfIsbn:"978-953-51-4116-7",doi:"10.5772/62977",price:119,priceEur:129,priceUsd:155,slug:"contemporary-leadership-challenges",numberOfPages:274,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"1fcedc3f8fe4dc3365c22aba9ed7af26",bookSignature:"Aida Alvinius",publishedDate:"February 1st 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5457.jpg",numberOfDownloads:50321,numberOfWosCitations:23,numberOfCrossrefCitations:24,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:36,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:83,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 14th 2016",dateEndSecondStepPublish:"May 5th 2016",dateEndThirdStepPublish:"August 9th 2016",dateEndFourthStepPublish:"November 7th 2016",dateEndFifthStepPublish:"December 7th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"145558",title:"Associate Prof.",name:"Aida",middleName:null,surname:"Alvinius",slug:"aida-alvinius",fullName:"Aida Alvinius",profilePictureURL:"https://mts.intechopen.com/storage/users/145558/images/2643_n.jpg",biography:"Aida Alvinius (Ph.D sociolog., Karlstad University, Sweden) is associate professor and university lecturer at the Department of Security, Strategy and Leadership, Swedish Defence University. She has published articles, chapters in books, and research reports within the field of organisation, collaboration, gender studies and leadership, sociology of disasters, and military sociology.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"National Defence College Kenya",institutionURL:null,country:{name:"Kenya"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"438",title:"Leadership",slug:"leadership"}],chapters:[{id:"53615",title:"Waking Up to the Power of Reflection to Unlock Transformation in People, Teams and Organizations",doi:"10.5772/66656",slug:"waking-up-to-the-power-of-reflection-to-unlock-transformation-in-people-teams-and-organizations",totalDownloads:2173,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"In our busy and frenetic world, leaders face overwhelm. Never before has there been so much change on so many fronts, demanding attention, squeezing out critical reflective time and thinking space. This is time and space to develop the personal capacities to lead with greater clarity, humanity and wisdom in order for transformation to occur, to learn how to reflect on experience, to sense what is needed and to lean into the futures’ emerging potential, instead of problem solving based on habitual thinking and yesterday's logic. This chapter will give reflection and reflective learning a rebranding, propelling it from dusty classrooms to become centre stage in a leader's toolkit, and will show how to apply the findings of the authors’ important new research in the workplace. The new leadership process “Reflect to Create!” with its seven human capacities for inspiring, creating and leading transformational change in today's VUCA world is introduced. The four core conditions and four key practices to embed the approach are also introduced.",signatures:"Elaine Patterson",downloadPdfUrl:"/chapter/pdf-download/53615",previewPdfUrl:"/chapter/pdf-preview/53615",authors:[{id:"189794",title:"M.A.",name:"Elaine",surname:"Patterson",slug:"elaine-patterson",fullName:"Elaine Patterson"}],corrections:null},{id:"52166",title:"Reflective Leadership: Learning to Manage and Lead Human Organizations",doi:"10.5772/64968",slug:"reflective-leadership-learning-to-manage-and-lead-human-organizations",totalDownloads:4028,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"This chapter mainly focuses on the concept of reflection as a process, both individual and collaborative, involving experience and uncertainty under the theme of reflective leadership. This type of leadership basically means learning to manage and lead human organizations. It originates from the concept of reflection defining leadership roles and responsibilities in all types of organizations. Focusing on reflection for learning in an effort to create reflective learning communities for all stakeholders taking part in both administrative and executive positions in organizations, this chapter is expected to contribute to leadership theories, to link theory and practice in concrete terms describing new leadership roles and responsibilities under the reflective thought considering its unique impact on organizational functioning.",signatures:"Süleyman Davut Göker and Kıvanç Bozkuş",downloadPdfUrl:"/chapter/pdf-download/52166",previewPdfUrl:"/chapter/pdf-preview/52166",authors:[{id:"190035",title:"Associate Prof.",name:"Süleyman Davut",surname:"Göker",slug:"suleyman-davut-goker",fullName:"Süleyman Davut Göker"},{id:"190044",title:"Dr.",name:"Kivanc",surname:"Bozkus",slug:"kivanc-bozkus",fullName:"Kivanc Bozkus"}],corrections:null},{id:"52673",title:"Developing Leadership Resilience Through a Sense of Coherence",doi:"10.5772/65770",slug:"developing-leadership-resilience-through-a-sense-of-coherence",totalDownloads:2207,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Leadership resilience is something that is accrued through experience. Becoming resilient necessarily involves the negative side of leadership and is one in which the leader often manifests symptoms of work‐induced stress. When in this space, the leader often feels isolated, and the voice of the leader is quietened as few leaders are able to say they are afraid. This case study provides insight into one leader's journey, during which he was able to find his voice. In so doing he developed a sense of coherence, which enabled the leadership episode to become part of a broader narrative. The process was facilitated through a coaching relationship, one in which a resilience and Salutogenic model/process and interpretative phenomenological analysis was utilised.",signatures:"Dee Gray",downloadPdfUrl:"/chapter/pdf-download/52673",previewPdfUrl:"/chapter/pdf-preview/52673",authors:[{id:"189709",title:"Dr.",name:"Dee",surname:"Gray",slug:"dee-gray",fullName:"Dee Gray"}],corrections:null},{id:"52779",title:"Leadership and Gender Differences—Are Men and Women Leading in the Same Way?",doi:"10.5772/65774",slug:"leadership-and-gender-differences-are-men-and-women-leading-in-the-same-way-",totalDownloads:5540,totalCrossrefCites:7,totalDimensionsCites:8,hasAltmetrics:1,abstract:"In this chapter, we aim to highlight the main gender differences in terms of leadership, to provide a critical comparative analysis, to discuss potential barriers that need to be overcome, and to find some ways of increasing organizational performance through a better leadership style. The focus will not be placed on the gender differences by themselves but on the ways these differences can positively influence the organizational performance. Our proposed chapter is mainly based on literature review as a methodology in its own right. Since literature review has revealed quite many divergent opinions, we also used questionnaires and interviews as data collection tools and we intend to present some of our results, without aiming to generalize all these results to different cultures. We cannot conclude that men’s leadership skills are more powerful and more important than women’s skills or vice versa, but it is clear that gender differences do exist and people should capitalize on them. We consider the word ‘complementary’ is better than the word ‘different’ when talking about leadership styles and that it is possible for leaders to develop a series of skills that are not necessarily traditionally linked to their own gender.",signatures:"Cătălina Radu, Alecxandrina Deaconu and Corina Frăsineanu",downloadPdfUrl:"/chapter/pdf-download/52779",previewPdfUrl:"/chapter/pdf-preview/52779",authors:[{id:"189086",title:"Ph.D.",name:"Cătălina",surname:"Radu",slug:"catalina-radu",fullName:"Cătălina Radu"}],corrections:null},{id:"52788",title:"Leadership: The Act of Serving",doi:"10.5772/65970",slug:"leadership-the-act-of-serving",totalDownloads:1798,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"This chapter is directed toward servant leadership as applied to the field of sport and athletic coaching. The purpose of the chapter is to give a brief definition of servant leadership and the application of such in coaching, and then to offer strategies for servant leadership as well as discuss several different research studies in athletic coaching. The conclusion simply states that though little research in coaching servant leadership exists, that which has been accomplished argues for implementation of coaching styles that are servant leadership focused.",signatures:"Sharon K. Stoll, Jennifer M. Beller, Peter VanMullem, Kevin Bryant\nand Marcis R. Fennell",downloadPdfUrl:"/chapter/pdf-download/52788",previewPdfUrl:"/chapter/pdf-preview/52788",authors:[{id:"189960",title:"Prof.",name:"Sharon Kay",surname:"Stoll",slug:"sharon-kay-stoll",fullName:"Sharon Kay Stoll"},{id:"213781",title:"Dr.",name:"Pete",surname:"Van Mullem",slug:"pete-van-mullem",fullName:"Pete Van Mullem"}],corrections:null},{id:"53703",title:"Leadership as an Art and a Responsibility: A Case Study of the Linguistic Choices of Nigeria's President Goodluck Jonathan",doi:"10.5772/67014",slug:"leadership-as-an-art-and-a-responsibility-a-case-study-of-the-linguistic-choices-of-nigeria-s-presid",totalDownloads:2059,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"President Jonathan of Nigeria continuously proclaimed that no blood of a Nigerian is worth his ambition before the 2015 elections. However, when he lost the presidential elections in 2015, it would be natural to expect him to become anti‐government and seek ill of the Nigerian people who rejected him. This study thus sought to determine the usage of language by President Jonathan in order to determine if he uses language responsibly and for the peace and unity of Nigeria. The data were sourced from his Facebook page. These were saved and analysed using the Chomsky theta theory and Halliday theme‐rheme system. The findings from the discussion show that Dr. Jonathan consistently exhibit responsible leadership in his linguistic usage. He continued to encourage and call on Nigerians to unite and support the government of the day. It was thus concluded that he has in him the spirit of leadership, which manifests in his positive use of language to encourage Nigeria's unity.",signatures:"Iyabode Omolara Akewo Daniel",downloadPdfUrl:"/chapter/pdf-download/53703",previewPdfUrl:"/chapter/pdf-preview/53703",authors:[{id:"190346",title:"Dr.",name:"Iyabode",surname:"Daniel",slug:"iyabode-daniel",fullName:"Iyabode Daniel"}],corrections:null},{id:"52733",title:"Critical Revision of Leadership Styles in Management and Company Cases",doi:"10.5772/65952",slug:"critical-revision-of-leadership-styles-in-management-and-company-cases",totalDownloads:2489,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"In this chapter, we expose from a critical point of view the main leadership styles and then three successful international case companies (Inditex, Santander, and Telefónica) that recognized their style and the strategies they developed. These cases will be the start point to discuss what kind of leadership seems to be more suitable for staff development and for a better management of human resources. Our hypothesis is that with these styles of leadership, effectiveness of human resources is enhanced, and productivity of enterprises is assured to remain competitive, adapted, and successful. Also, we assume that there are some cultures in which these styles of leadership are better prepared, as the culture predisposes employees to accept and assimilate them. We are aware that worldwide business culture has a long way to progress toward more evolved leadership styles. This business culture is partly linked, or it is concomitant to the value or condition that is given to citizens in societies.",signatures:"Beatriz Peña-Acuña",downloadPdfUrl:"/chapter/pdf-download/52733",previewPdfUrl:"/chapter/pdf-preview/52733",authors:[{id:"194887",title:"Dr.",name:"Beatriz",surname:"Peña-Acuña",slug:"beatriz-pena-acuna",fullName:"Beatriz Peña-Acuña"}],corrections:null},{id:"52477",title:"Ethical Leadership in Crisis Management: The Role of University Education",doi:"10.5772/65497",slug:"ethical-leadership-in-crisis-management-the-role-of-university-education",totalDownloads:2113,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Ethical leadership is a necessary ingredient for successful crisis management. The study outlines generalizable prescriptive remedial steps that can be taken by business leaders faced by crises. But these remedial steps are simply the “bricks and mortar” of effective crisis management. The “pulsating soul” of ethical leadership is required to give such remedial steps the necessary moral compass for the initiation and sustained directional focus required for successful crisis management operationalization. The study’s objective and purpose are twofold. First, it outlines a model of crisis management derived from recent case studies of best practice and briefly indicates how such practices reduce financial losses to the organizations concerned if correctly implemented by ethical leaders. Second, the study aims to show how ethical leadership required for effective crisis management might be nurtured through specific ethics-oriented postgraduate university instruction. The study suggests that these two aspects, ethical leadership and prescriptive steps to follow in the event of a crisis, are not only mutually reinforcing but also indispensable in effective crisis management.",signatures:"David A.L. Coldwell",downloadPdfUrl:"/chapter/pdf-download/52477",previewPdfUrl:"/chapter/pdf-preview/52477",authors:[{id:"189110",title:"Prof.",name:"David",surname:"Coldwell",slug:"david-coldwell",fullName:"David Coldwell"}],corrections:null},{id:"52362",title:"Development of Leadership Competencies During Studies at an Institution of Higher Education: Students’ Opinion",doi:"10.5772/65269",slug:"development-of-leadership-competencies-during-studies-at-an-institution-of-higher-education-students",totalDownloads:4687,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"In order for more professionals to take the role of leaders, the systematic attitude to this question is necessary and one of the aspects is that it is needed to begin preparing students for the leadership at a higher school. Although there are many facts about the importance of developing of leadership competences at higher schools, there is a lack of research on the subject of students’ opinion about leadership development in Lithuania, as well as in other countries. That is why the research considering this issue is relevant practically and quite new scientifically. The aim of this study is to reveal students’ opinion about developing leadership competences during the studies at an institution of higher education. For this purpose, in the year 2015 and 2016 the research involving 857 last year students from different Lithuanian higher education institutions was fulfilled. The research has shown that the demand of students to develop leadership competences is significantly high and it is realized only partially. The research also confirmed the idea that the development of the leadership competencies could not be based on only one subject, but the integrated strategy needs to be applied. Based on the findings, some recommendations for higher education institutions were formulated as well.",signatures:"Aelita Skarbalienė",downloadPdfUrl:"/chapter/pdf-download/52362",previewPdfUrl:"/chapter/pdf-preview/52362",authors:[{id:"189070",title:"Dr.",name:"Aelita",surname:"Skarbalienė",slug:"aelita-skarbaliene",fullName:"Aelita Skarbalienė"}],corrections:null},{id:"52214",title:"Leadership in Non-Profit Organisations",doi:"10.5772/65268",slug:"leadership-in-non-profit-organisations",totalDownloads:2092,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Emerging at the end of the twentieth century, non-profit sector has taken on a new significance. Non-governmental organisations, health institutions, educational institutions and museums are examples for the variety of non-profit organisations. Museums are defined as the symbols of national cultures and bridges uniting the past with the present. However, it may be suggested that this definition has lost its validity on a large scale due to globalism that penetrated into our lives in the twentieth century. Globalism and multiculturalism played an important role in the industrialisation of culture, and being the symbols of culture, museums assumed the form of dynamics within this industry. Accordingly, the concept of museum leadership gained importance. The increasing competition amongst museums makes leadership more crucial. Compared to other sectors, museums have not been studied enough in terms of leadership and the late, but the necessary attempt to improve museum leadership is of vital importance for cultural industry. This study first discusses leadership and non-profit organisations separately, and afterwards, it investigates into leadership in non-profit organisations. Lastly, it elaborates on museum leadership, which is a popular concept of the modern day.",signatures:"Beste Gökçe Parsehyan",downloadPdfUrl:"/chapter/pdf-download/52214",previewPdfUrl:"/chapter/pdf-preview/52214",authors:[{id:"189113",title:"Dr.",name:"Beste",surname:"Gokce Parsehyan",slug:"beste-gokce-parsehyan",fullName:"Beste Gokce Parsehyan"}],corrections:null},{id:"52851",title:"Industrial Leadership: Leading Within the Field of Construction and Design",doi:"10.5772/65680",slug:"industrial-leadership-leading-within-the-field-of-construction-and-design",totalDownloads:3762,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The structure of the design and construction organizations is different from that of the service or manufacturing industry. Although design and construction organizsations are parts of the construction industry, they are different from each other, also. This chapter is based on the researches investigating the leadership behaviours of construction professionals and consists basically of two main sections. In the first section, the concept of leadership and importance of leadership in design and construction processes will beis discussed. In this first section, firstlyinitially, as the leaders of the design teams, the importance of leadership skills of architects in both architectural design teams and other design teams, and, secondly, the importance of leadership skills of construction professionals will beis evaluated. In the second section, the focus of the study will befocuses on the evaluation of leadership behaviours of construction professionals with a literature review of previous researches. In this second section, initially, the leadership stiles in design teams, and secondly leadership stiles of construction teams will beis evaluated.",signatures:"Esin Kasapoğlu",downloadPdfUrl:"/chapter/pdf-download/52851",previewPdfUrl:"/chapter/pdf-preview/52851",authors:[{id:"189772",title:"Dr.",name:"Esin",surname:"Kasapoglu",slug:"esin-kasapoglu",fullName:"Esin Kasapoglu"}],corrections:null},{id:"52757",title:"Leadership Requirements for Successful Implementation of Lean Management in Health Care: A Systematic Review of the Literature",doi:"10.5772/65653",slug:"leadership-requirements-for-successful-implementation-of-lean-management-in-health-care-a-systematic",totalDownloads:2279,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Lean is a management philosophy aimed at increasing value for end users by controlling waste. As such, it is a promising approach for health-care organizations to improve quality and control costs. Yet the transition to Lean management often fails in health-care organizations, commonly due to a lack of specific Lean leadership skills. This research addresses a gap in the knowledge about leadership requirements for successful Lean implementation in health-care organizations. A systematic literature search was performed using the MEDLINE, EMBASE and Emerald databases, resulting in the selection of 23 articles. Analysis of these articles confirmed the five Lean leadership principles identified in the manufacturing literature—improvement culture, self-development, employee training, going to the gemba, and hoshin kanri—and identified specific leadership behaviors, skills, characteristics, and attitudes for each principle. A sixth leadership principle, that of customer value, was also identified. This research contributes to existing Lean literature by providing new insights into leadership requirements for Lean transitions in health care. A new leadership framework is suggested for Lean leadership requirements during Lean implementation. In practice, this research provides health-care leaders with a practical framework and guidance with which to successfully implement Lean in a health-care institution.",signatures:"Kjeld H. Aij and Marion E. Veth",downloadPdfUrl:"/chapter/pdf-download/52757",previewPdfUrl:"/chapter/pdf-preview/52757",authors:[{id:"190181",title:"Dr.",name:"Kjeld",surname:"Aij",slug:"kjeld-aij",fullName:"Kjeld Aij"},{id:"195731",title:"Dr.",name:"Marion",surname:"Veth",slug:"marion-veth",fullName:"Marion Veth"}],corrections:null},{id:"52389",title:"Leadership and Healthcare Services",doi:"10.5772/65288",slug:"leadership-and-healthcare-services",totalDownloads:1878,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The reasons why organizations make changes in various fields, especially in their structure, include various changing situations such as globalization, increasing awareness in human rights and employee rights, developments in communication technologies, and changes in people’s expectations and demands. These changes in their structures have brought along changes in their management perspectives. In shaping the new management perspective which became a field of study which contains specialties, international competition has also played a major role as well as abovementioned notions of globalization, human rights, and communication technologies. Organizations keeping up with the time and reaching success by achieving competitive superiority in their field of activity are closely related with being managed by real leaders and these leaders’ behaviors and attitudes. Competition in healthcare sector has increased as a result of raised awareness in the right of healthy life which is one of the fundamental rights of individuals and that their demands were developed in that direction. In addition to this, it is quite important that the leaders, who are able to guide people, have ethical leadership characteristics in order to set an example to especially people who follow them and show righteousness and honesty in their actions.",signatures:"Bilge Sözen Şahne and Sevgi Şar",downloadPdfUrl:"/chapter/pdf-download/52389",previewPdfUrl:"/chapter/pdf-preview/52389",authors:[{id:"184120",title:"Dr.",name:"Bilge",surname:"Sözen Şahne",slug:"bilge-sozen-sahne",fullName:"Bilge Sözen Şahne"},{id:"190488",title:"Prof.",name:"Sevgi",surname:"Şar",slug:"sevgi-sar",fullName:"Sevgi Şar"}],corrections:null},{id:"52409",title:"Leadership in Nursing",doi:"10.5772/65308",slug:"leadership-in-nursing",totalDownloads:13219,totalCrossrefCites:6,totalDimensionsCites:8,hasAltmetrics:0,abstract:"The nursing literature, until recently presents the phenomenon of leadership as associated with nurse executives and formal leadership roles. That is leadership is defined in terms of an interactive process where followers are motivated and empowered to accomplish specific goals. The purpose of this chapter is to present the phenomena of nursing clinical leadership and leadership at the bedside, which is a new area of research in nursing. This chapter proposes that leadership is not merely linked to top management levels, but it can be developed and implemented at bedside for nurses. Clinical leadership skills focus on patients and healthcare teams rather than formal leadership position. In addition, clinical leadership relates to nursing professional activities, which provide direct care at bedside, which differs from the traditional nursing leadership notion. Thus, acquiring clinical leadership skills is crucial for nurses who provide direct patient care. This allows nurses to direct and support patients and healthcare teams when providing care. Furthermore, it is crucial that nurses develop an effective leadership role to deliver high-quality care and ensure patient safety while engaging in numerous daily leadership roles. Moreover, it emphasized the importance of the cooperation between nursing education programs and healthcare organizations in preparing nurses to be effective leaders by 2020 for the new era of health care.",signatures:"Reem Nassar AL-Dossary",downloadPdfUrl:"/chapter/pdf-download/52409",previewPdfUrl:"/chapter/pdf-preview/52409",authors:[{id:"194238",title:"Dr.",name:"Reem",surname:"Al-Dossary",slug:"reem-al-dossary",fullName:"Reem Al-Dossary"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5472",title:"Gender Differences in Different Contexts",subtitle:null,isOpenForSubmission:!1,hash:"2f67b9514d1d24a468b8cdf15f0c1cdb",slug:"gender-differences-in-different-contexts",bookSignature:"Aida Alvinius",coverURL:"https://cdn.intechopen.com/books/images_new/5472.jpg",editedByType:"Edited by",editors:[{id:"145558",title:"Associate Prof.",name:"Aida",surname:"Alvinius",slug:"aida-alvinius",fullName:"Aida Alvinius"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6781",title:"Leadership",subtitle:null,isOpenForSubmission:!1,hash:"f3afd6d261e6aec6511ce90e5c0601ca",slug:"leadership",bookSignature:"Suleyman Davut Göker",coverURL:"https://cdn.intechopen.com/books/images_new/6781.jpg",editedByType:"Edited by",editors:[{id:"190035",title:"Associate Prof.",name:"Süleyman Davut",surname:"Göker",slug:"suleyman-davut-goker",fullName:"Süleyman Davut Göker"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7799",title:"Digital Leadership",subtitle:"A New Leadership Style for the 21st Century",isOpenForSubmission:!1,hash:"04acd8ff54f1ae641699692e90c508b3",slug:"digital-leadership-a-new-leadership-style-for-the-21st-century",bookSignature:"Mario Franco",coverURL:"https://cdn.intechopen.com/books/images_new/7799.jpg",editedByType:"Edited by",editors:[{id:"105529",title:"Dr.",name:"Mário",surname:"Franco",slug:"mario-franco",fullName:"Mário Franco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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By measuring the contact angle for a liquid droplet on a solid surface, the surface can be primarily divided into three categories; Super hydrophobic (150° ≤ θ < 180°) hydrophobic (90° ≤ θ < 150°), and hydrophilic (0 < θ < 90°). The contact angle, which is a function of the surface energy of a sample, determines if a given liquid drop will roll up or spread when deposited on it. In the past few decades, the wettability of solid surfaces has raised considerable interest because of its application in various fields, from microfluidics to chemistry. Wetting is also crucial in the bonding or adherence of two materials. Wetting and the surface forces that control wetting are also responsible for other related effects, including capillary effects.
\r\n\r\n\tThis book aims to introduce readers to the fundamentals of wetting phenomena, different methods for the fabrication or modification of the wetting behavior of a surface, and also its applications in various fields. The book also aims to introduce the readers to the recent advances and research trends in wetting.
",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"6583ba7e352af61a955a2c437b9237b9",bookSignature:"Dr. Pratibha Goel, Dr. Samir Kumar and Dr. Kavita Yadav",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10046.jpg",keywords:"Cassie-Baxter State, Wenzel State, Metastable State, Rough Surface, Surface Wetting Characterization, Water Droplet Dynamics, Thermoplasmonic, Marangoni Effect, Self-cleaning Surfaces, Smart Surface, Molecular Dynamic Simulation, Free Energy",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"December 16th 2019",dateEndSecondStepPublish:"March 5th 2020",dateEndThirdStepPublish:"May 4th 2020",dateEndFourthStepPublish:"July 23rd 2020",dateEndFifthStepPublish:"September 21st 2020",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"315718",title:"Dr.",name:"Pratibha",middleName:null,surname:"Goel",slug:"pratibha-goel",fullName:"Pratibha Goel",profilePictureURL:"https://mts.intechopen.com/storage/users/315718/images/system/315718.jpg",biography:"Dr. Pratibha Goel received her PhD from the Indian Institute of Technology Delhi (IITD) in 2016. Since then, she has been a postdoctoral fellow at Peking University (China), CSIR-NPL (India), and Imperial College London (UK). Currently, she is working as a postdoctoral research associate at the University of Notre Dame, USA. Her research interests include nanostructured surfaces for tunable wetting properties and Surface-enhanced Raman Spectroscopy (SERS). Currently, she is working on nanopipette-based, single-molecule-based biosensors.",institutionString:"University of Notre Dame",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Notre Dame",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:{id:"296661",title:"Dr.",name:"Samir",middleName:null,surname:"Kumar",slug:"samir-kumar",fullName:"Samir Kumar",profilePictureURL:"https://mts.intechopen.com/storage/users/296661/images/system/296661.png",biography:'I have extensive experience in tailoring the nanomorphology using a physical self-assembly induced nanostructure fabrication technique called \\"Glancing Angle Deposition\\" for developing novel optical films and plasmonic substrates for SERS, water repellent surfaces, bio/chemical sensing, and photocatalysis. 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Filipino cuisine is no exception as distinct regional flavors stem from the unique food preparation techniques and culinary traditions of each region. Although Philippine indigenous foods are reminiscent of various foreign influences, local processes are adapted to indigenous ingredients and in accordance with local tastes. Pervasive throughout the numerous islands of the Philippines is the use of fermentation to enhance the organoleptic qualities as well as extend the shelf-life of food.
Traditional or indigenous fermented foods are part and parcel of Filipino culture since these are intimately entwined with the life of local people. The three main island-groups of the Philippines, namely – Luzon, Visayas, and Mindanao, each have their own fermented food products that cater to the local palate. Fermentation processes employed in the production of these indigenous fermented foods often rely entirely on natural microflora of the raw material and the surrounding environment; and procedures are handed down from one generation to the next as a village-art process. Because traditional food fermentation industries are commonly home-based and highly reliant on indigenous materials without the benefit of using commercial starter cultures, microbial assemblages are unique and highly variable per product and per region. Hence the possibility of discovering novel organisms, products, and interactions are likely.
Various microorganisms are involved in common food fermentation processes. In particular, lactic acid bacteria (LAB) in food is a type of biopreservation system. They not only contribute to the flavor of the food but LAB are also able to control pathogenic and spoilage microorganisms through various ways that include, but are not limited to, production of peroxidases, organic acids, and bacteriocins. Traditionally, identification of LAB in foods is largely dependent on culture-based methods; and properties of each isolate are evaluated under controlled conditions. However, with the advent of molecular techniques, the enumeration of microorganisms missed by culture-dependent methods is now possible. Also, as more LAB metabolites, such as bacteriocins, are being reported, a wider database for identification and comparison with potential novel products are now available.
As the production and consumption of traditional fermented food products become increasingly relevant in the face of rapidly increasing population and food insecurity, more research and development to ensure the safety and nutritional quality of these fermented products is warranted. For a more extensive discussion of the principles and technology of Philippine fermented foods, the readers are directed to Sanchez (2008). This book is a detailed reference based on decades of research. Some data from the book will be presented again here in addition to other data from more recent studies. It is not the intention of this present paper to repeat what has been presented in the book, especially regarding fermentation processes, but only to present, as complete as possible, the data that are available regarding LAB present in indigenous/traditional fermented foods.
This paper aims to briefly review the various lactic acid-fermented indigenous fermented specialties in the different regions of the Philippines. Majority of the discussion will focus on recent data gathered from bacteriocin research and metagenomics studies of Philippine fermented specialties. Lastly, the health applications of the different fermented food products and their development as functional foods will be evaluated.
There are various lactic acid-fermented indigenous food products in the Philippines. Table 1 gives a summary of these different fermented specialties found in the different regions. Although a particular product type can be seen throughout the whole country, the texture, taste, and appearance would vary depending on the local taste, materials used, and process employed. For example, bagoong is a common fermented fish paste found all over the Philippines but the characteristic of the product found in Luzon is different from that found in the Visayas and Mindanao regions. Bagoong also takes on different names; there is bagoong na isda, bagoong alamang, bagoong na sisi, and guinamos (Sanchez, 2008). A product that is processed in a similar manner is dayok; it is made of brined fish entrails. Research indicates that this is also a lactic acid-fermented food but the LAB involved have not been identified yet (Besas and Dizon, 2012). Longanisa is sausage made of beef, pork, or chicken. It also takes on many forms depending on where it is made. The more famous ones are Vigan Longanisa in Northern Luzon, Pampanga Longanisa in Central Luzon, Lucban Longanisa in Southern Luzon, and Cebu Longanisa in the Visayas. The tastes vary from spicy, garlicky, sour, to sweet.
In lactic acid-fermented foods, LAB are important in preventing the growth of spoilage organisms, and altering flavor, aroma, and texture of the product. Although LAB are initially present in low numbers in the raw materials used, they soon proliferate as other organisms are inhibited by the initial addition of salt and as the continuous growth of LAB decreases the pH of the food making it less conducive for growth of other organisms. Recent studies, however, have shown that there are a lot more benefits that can be derived from LAB in traditional fermented foods.
Fermented vegetables, fruits | Burong mustasa | Luzon | Mustard leaves, cooked rice and/or rice washings | Side dish | |
Burong pipino | Whole Phil | cucumber | Side dish | ||
Burong mangga | Whole Phil | Immature mango | Side dish | ||
Atchara | Whole Phil | Immature papaya or chayote, or turnip (singkamas) | Unknown | Side dish | |
Cheese | Kesong puti | Luzon, Visayas | Cow or carabao milk | White soft cheese | |
Fermented fish and fishery products | Balao-balao | Luzon | Cooked rice, shrimp, salt | Side dish, condiment | |
Burong-isda | Luzon | Freshwater fish, rice, salt | Side dish, condiment | ||
Tinabal | Visayas | Parrot fish (for tinabal molmol) and frigate fish (for tinabal mangko), salt | Side dish, viand | ||
Burong talangka | Luzon | Small shore crabs ( | Side dish, viand | ||
Patis | Whole Phil | Small fish, salt | Fish sauce (patis), fish paste (bagoong), used as condiment, sauce, flavoring agent, viand | ||
Bagoong isda | Whole Phil | Small fish, salt | |||
Bagoong alamang | Whole Phil | Small shrimps, salt | |||
Bagoong na sisi | Visayas | Shell fish, salt | |||
Guinamos | Bagoong isda in Visayas, Mindanao | Salt water small fish (dilis/belabid – | Condiment, viand, side dish | ||
Dayok | Visayas, Mindanao | Fish entrails, salt | Unidentified LAB | Condiment, viand, side dish | |
Fermented meat, sausages | Longanisa | Whole Phil | Ground pork, beef, or chicken meat, spices and preservatives | Viand | |
Agos-os | Visayas | Sweet potato and ground pig’s head | Viand | ||
Burong kalabi | Luzon | Cooked rice, ground carabao meat | Side dish, viand | ||
Burong babi | Luzon | Cooked rice, ground pork | Side dish, viand | ||
Fermented rice, cassava, sugar cane, coconut, soya | Puto | Whole Phil | Rice, sugar | Steamed rice cake | |
Bibingka | Whole Phil | Rice, sugar | Baked rice cake | ||
Tapuy | Luzon | Rice, glutinous rice | Wine; beer | ||
Pangasi | Mindanao | Rice | Unknown | Wine | |
Landang | Visayas, Mindanao | Cassava, or buli palm flour | Unknown | Dried jelly pellets pellets, rice substitute | |
Puto balanghoy | Mindanao | Cassava | Unknown | Steamed cake | |
Basi | Luzon | Sugar cane | Unknown | Wine | |
Suka | Whole Phil | Sugar cane juice (for sukang Iloco), palm inflorescence sap (for sukang tuba) | Vinegar, condiment, flavoring | ||
Sinamak | Luzon | Sugar cane juice, spices (chilies, onions, garlic) | Unknown | Spiced vinegar, condiment, flavoring | |
Pinakurat | Visayas, Mindanao | Coconut sap, chilies, salt, various spices | Unknown | Spiced vinegar, condiment, flavoring | |
Tuba | Whole Phil | Coconut sap | Unknown | Wine | |
Lambanog | Whole Phil | Coconut sap | Unknown | Wine | |
Toyo | Whole Phil | Soybeans | Condiment, flavoring agent, seasoning |
Regional Lactic Acid-Fermented Specialties in the Philippines
Bacteriocins are antimicrobial proteins or peptides produced by certain bacterial strains. Unlike the peptide antibiotics they usually have a narrow spectrum of antimicrobial activity, usually inhibiting growth of closely related bacterial species or strains and lacking lethality to the producer strain (Riley and Wertz, 2002).
The bacteriocins of LAB are small, cationic, hydrophobic, or amphiphilic peptides or small proteins, composed of 20 to 60 amino acid residues (Chen & Hoover, 2003). The bactericidal mode of action and biochemical properties depend on the protein moiety that could be specific to a particular LAB strain,
LAB bacteriocins have attracted attention in recent years because of their generally regarded as safe (GRAS) status and good value as natural biopreservatives which can find applications in the food and cosmetic industries (Cleveland et al., 2001; Daeschel, 1993; Riley and Wertz, 2002). Nisin, produced by strains of
Some efforts on the isolation of bacteriocin-producing LAB had been started for more than a decade now in two major research institutions in the country namely: University of the Philippines Los Banos (specifically, the National Institutes of Molecular Biology and Biotechnology or BIOTECH-UPLB and the Institute of Biological Sciences or IBS-UPLB) and the Philippine Root Crop Research and Training Center, Visayas State University (VSU). These two institutions branched out knowledge on bacteriocin research through affiliate tutorship, as thesis advisers and as trainors to students and staff from a few other academic institutions which also did bacteriocin researches like University of Santo Tomas (UST), University of the Philippines Manila (UPM), De La Salle University (DLSU) and Ateneo de Manila University (ADMU). BIOTECH-UPLB and IBS-UPLB jointly worked on bacteriocins of
Various fermented food products with proteinaceous components were the major sources of isolated LAB for bacteriocin screening. Such fermented food products are home-grown or produced by small enterprises and are still commercially available from public markets in Luzon, Philippines and some parts of the Visayas like Leyte island. Examples of Philippine indigenous fermented foods that were good sources of bacteriocin-producing LAB are fermented rice and shrimp (
In one of the first isolation studies for bacteriocinogenic LAB, various proteinaceous fermented foods native to Central and Southern, Philippines were screened for bacteriocin-producing bacterial isolates. Seventy one out of several hundreds of colony-forming unit isolated by agar plate streaking were found antagonistic to the indicator microorganism,
Being pleomorphic, identification of LAB is quite challenging. A combination of various microbiological and molecular biology tools would help in finding the real identity. Banaay et al. (2004) did a thorough identification of the bacteriocinogenic LAB isolate using conventional morphological, biochemical and physiological methods, chemotaxonomic methods, as well as molecular methods. This is especially relevant to the identification of
ISOLATE/ STRAIN No. | (primer) HOMOLOGY to | |||
AA-5a | partial 16S rRNA gene ID: | (1492R)98% 99% (27F) 99% 99% | Elegado et al. 2003 | ped + ; REP and RAPD |
4E2 | partial 16S rRNA gene ID: | (1492R) 98% 99% (27F) 99% 99% | Apaga (2012) | ped+ |
4E4 | partial 16S rRNA gene ID: | (1492R) 97% 99% (27F) 98% 99% | Apaga (2012) | ped+ |
4E5 | partial 16S rRNA gene ID: | (1492R) 99% (27F) 99% | Laxamana et al. (2011) | ped+ ; REP |
4E6 | partial 16S rRNA gene ID: | (1492R) 98% 99% (27F) 99% 99% | Apaga (2012) | ped+;[ 99% |
4E10 | partial 16S rRNA gene ID: | (1492R) 96% 99% (27F) 99% 99% | Apaga (2012) | ped- |
4BL7 | partial 16S rRNA gene ID: | (1492R) 98% 99% (27F) 99% 99% | Apaga (2012) | ped+ |
3G3 | API CHL50 ID: partial 16S rRNA gene ID: P. acidilactici | (1492R) 99% (27F) 98% | Elegado and Perez (2012) | ped+ ; REP; ped+ |
3G8 | partial 16S rRNA gene ID: | (1492R) 99% (27F) 98% | Elegado and Perez (2012) | ped+ |
3F3 | partial 16S rRNA gene ID: | (1492R) 95% (27F) 98% 99% | Apaga (2012) | ped+ |
3F8 | partial 16S rRNA gene ID: | (1492R) 98% 99% (27F) 99% 99% | Apaga (2012) | ped+ |
3F10 | partial 16S rRNA gene ID: | (1492R) 97% 99% (27F) 97% 99% | Apaga (2012) | ped+ [99% |
IG7 | partial 16S rRNA gene ID: | (1492R) 97% 99% | Apaga (2012) | ped+ [100% pediocin operon;PSMB74]; |
K2A2-3 | API: partial 16S rRNA gene ID: | (1492R) 97% 99% (27F) 99% 99% | Villarante (2011); Elegado and Perez (2012) | ped+ ; plan+ ped+ ; REP |
K2A2-1 | API: | - | Abuel (2007) | ped+ ; plan+ ped+ |
K2A2-5 | API: partial 16S rRNA gene ID: | (1492R) 97% 99% (27F) 99% 99% | Apaga (2012) | ped+ [99% |
K2A1-1 | partial 16S rRNA gene ID: | (1492R) 99% 99% (27F) 98% 99% | Apaga (2012) | ped+ |
K3A2-2 | API: partial 16S rRNA gene ID: | - | ped+ ; plan+; ped+ | |
K3A2-3 | partial 16S rRNA gene ID: | 100% | Elegado and Perez (2012) | ped+ |
S3 | partial 16S rRNA gene ID: | (1492R) 98% 99% (27F) 97% 99% | Apaga (2012) | ped+ [99% pediocin operon; pSMB72]; |
Identification and bacteriocin gene determination of putative
Purification of bacteriocin peptides or small proteins into homogeneity is necessary in order to fully characterize them, particularly the determination of molecular mass, the primary structure or amino acid sequence and secondary structure. For pediocin, it was found that a simple and rapid method is effective for its purification. This method involves adsorption of pediocin onto the cell wall of the producer cell at pH 6 and 0.05 M NaCl and then subsequent desorption at pH 2.0 and 1 M NaCl (Elegado et al., 1997; Yang et al., 1992). This method seemed more applicable to pediocin but not with the lactococcin, nisin or plantaricin. The reason is not clear but it could be related to variation in cell wall properties. The pH-adsorption/desorption method was able to provide materials for pH and temperature tolerance assays, estimation of molecular mass through SDS-PAGE, residual activity determination after protease, amylase and other enzyme actions (Laxamana et al., 2011). Enough amount of semi-purified bacteriocin from pediococci using this method was obtained for further purification through preparative reverse phase HPLC for various characterization studies, including the determination of secondary structures by circular dichroism and confirmation of double bonds through trypsin digestion and electrospray mass spectrometry (Elegado and Kwon, 1998). Other preparative purification methods prior to reverse phase HPLC and spectrometry included ion exchange chromatography and gel filtration chromatography (Elegado et al., 2003), and hydrophobic interaction chromatography (Villarante et al., 2011). This method could also be applied with bacteriocins of pediococci and lactobacilli. The properties obtained from well characterized bacteriocinogenic LAB are shown in Table 3.
AA5a | pediocin | pH adsorption/desorption Reversed-phase HPLC | Tolerant to pH 2-9 and 121 °C | |
BS25 | plantaricin | Gel filtration chromatography Reversed-phase HPLC | MW = 3,830 Da | |
K2a2-3 | pediocin | Hydrophobic interaction and ion-exchange chromatographies Reversed-phase HPLC | MW = 4,626 Da | |
K2a2-1 | pediocin | pH adsorption/desorption | Optimum pH = 5-7 Resistant to boiling but not to autoclaving | |
4E5 | pediocin | pH adsorption/desorption | Tolerant to pH 2-9; slight loss of activity at 100 °C; loss of activity at 121 °C; tolerates high salt; est. MW = 6,500 Da by SDS-PAGE |
List of purified and characterized bacteriocins from LAB isolated from Philippine indigenous fermented foods.
Bacteriocin production is largely dependent on the nutrients and nitrogen content of the fermentation medium. For instance, increased yeast extract concentration and polypeptone amount increases bacteriocin production. Molasses, raw sugar and sago hydrolyzates of amylase digestion were found to be good carbon sources. Other possible substrate base and supplements are cheese whey, coconut water and rice bran extract. Initial sugar concentration of usually 2 to 3% and inoculation rate of 3% by volume of at least 108 cells/mL provides good bacteriocin production (Elegado et al., 2001).
Bacteriocin production is highly dependent on cell or biomass growth. LAB are microaerophilic and most are either mesophilic or slightly thermophilic. The following conditions are applicable to their production: pH= 5.5 to 6.0; temperature = 35 – 40 °C; agitation = 50 rpm; without aeration. Usually, bacteriocin is optimally produced or secreted in the culture broth during the early stationary phase of growth. For
Pediocins and plantaricins are the commonly found bacteriocins in Philippine fermented foods so far studied. Their antimicrobial properties have been investigated in several studies (Banaay et al., 2004; Elegado et al., 2003, 2004, 2007; Marilao et al., 2007). Although pediocins and plantaricins show promise, their applications are limited at present because it is a well-known fact that other bacteriocins aside from nisin are not yet approved for food use. For pediocins and plantaricins, the most practical use for now would be dermatological and animal health care use. But since the bacteriocin-producing LAB are of GRAS status, those with probiotic properties such as tolerance to acidic pH (2.0 -3.0) and bile (0.3%) and adhesion properties to intestinal mucosa would be an advantage when used as adjunct inocula in fermented food products (Gervasio and Lim, 2007).
Perhaps another importance of bacteriocin-producing LAB is their effectiveness in biomedical applications. In one study, for example, partially-purified pediocin K2a2-3, through pH-mediated bacteriocin extraction method, was found cytotoxic against human colon adenocarcinoma (HT29) and human cervical carcinoma (HeLa) cells
An offshoot of the initial research on bacteriocins of LAB isolated from indigenous fermented foods is the emergence of probiotic research towards developing functional foods for biomedical applications. Probiotics refer to microorganisms that, when administered in adequate amounts, confers health benefits to the host. Although there are many microorganisms that can be considered as probiotics, LAB are the most common types because they produce antimicrobial compounds that inhibit other harmful microorganisms, they are able to tolerate acids and bile present in the digestive system, and they are able to adhere and establish themselves in the gut surfaces.
Many benefits have been ascribed to probiotics. For example,
Traditional culture-based methods have been used for isolating LAB from fermented foods. These studies form the basis for the starter cultures used in food fermentation technologies employed for commercial production. Sanchez (2008) gives detailed information on the different technologies and cultures used for the production of some traditional as well as developed technologies that have arisen from the culture-based studies conducted in earlier years.
In recent years culture-based approaches in LAB isolation have become more targeted for detection of bacteriocin-producers and those that have potential as probiotics. In one initiative, LAB isolates from fermented foods were screened for bacteriocin production and a PCR-based assay was used to detect specific bacteriocin-encoding genes. Acid and bile tolerance were also determined. Among all the isolates tested,
With the advent of molecular techniques, the existence of non-culturable microorganisms has been acknowledged especially since the occurrence of culture-bias is already well-accepted. Culture-independent approaches, therefore, have been gaining popularity in microbial diversity studies and this includes researches on microorganisms found in fermented foods. The microbial populations in selected Philippine fermented foods were assessed through Polymerase Chain Reaction followed by Denaturing Gradient Gel Electrophoresis (PCR-DGGE) in two recent studies (Dalmacio et al., 2011; Larcia, 2010). Food samples tested include
The results of the two studies using molecular approaches in defining diversity of LAB in Philippine fermented foods show that culture-independent approaches are efficient tools for the analysis of microbial populations in fermented foods. Majority of the identified bacteria (LAB and other bacterial groups) have not been reported in culture-dependent studies. As such, the isolated bacterial 16S rRNA genes were cloned to have an initial partial 16S rRNA gene library for Philippine fermented foods (Dalmacio et al., 2011).
Anti-Obesity
Obesity is defined as an abnormal or excessive fat accumulation that presents risks to health. Probiotics can help in fighting obesity by reducing lipid absorption through its action on bile acid metabolism, and by assimilation of cholesterol thus eliminating it from the host’s system. Several studies were conducted to examine anti-obesity properties of different probiotic strains.
In one study, oral administration of
Recently, it has been postulated that the development of obesity may be caused by a shift in the composition of the gut microbiota towards the Firmicutes population (Ley et al., 2005). Firmicutes characterize obese versus lean/non-obese individuals together with a drop or no change in Bacteroidetes (Delzenne and Cani, 2010). Interestingly, Ley et al. (2006) found that a low fat diet had an effect to reverse the shift of Firmicutes/Bacteroidetes proportion. Because of this, dietary manipulation has been seen as a potential means of changing bacterial populations in the colonic microbiota and perhaps treating or at least preventing diseases like obesity. Although the root cause of obesity is excessive caloric intake coupled with a sedentary lifestyle (Blaut and Bischoff, 2010), Ley et al. (2005) proposed in their findings that alteration in the populations of mice gut microflora may have caused or may have been an effect of obesity. Because of this, current researches aim in using probiotics in the treatment of diseases such as obesity.
In two related studies (Arroyo and Fabiculana, 2011; Parungao et al., 2012), the effect of a functional food containing
Immuno-enhancement
A preliminary
Reduction of blood glucose levels
A study by Ngo et al. (2008) showed that oral administration of kefir, a common fermented food consumed by the elderly, significantly decreased blood glucose levels and body weight of diabetic obese male Sprague Dawley rats. The results of the study showed lower blood glucose levels (from 198.5 to 105.6 mg/dL) and clinically lower body weights (from 342.9 to 311.5 g) of the treated diabetic-obese rats than the untreated diabetic-obese control group.
Prevention of hypercholesterolemia
The effect of
The development of functional foods containing known probiotic strains stems from earlier researches on bacteriocins and isolation of potential probiotics from traditional fermented foods. The beneficial effects of probiotic-supplemented chocolate bars (Arroyo et al., 2010; Arroyo and Fabiculana, 2011), fermented mustard leaves (Calapardo et al., 2006), and coffee wine (Parungao, 2007) have been investigated. Initial studies on mango-milk and carrot juice drinks supplemented with probiotic strains have also been conducted (Bugarin et al., 2010; Elegado et al., 2005). These potential functional foods contain probiotic strains, previously isolated from traditional fermented foods such as
Aside from the research works presented earlier in this paper as well as on-going follow-up studies related to them, future goals may include research on a variety of other possible biomedical applications of LAB with potential probiotic properties. The effect of probiotics on
Much is still to be learned about the existing probiotic strains. The molecular biology and genomics of these isolates may be pursued in order to further elucidate their properties and mechanisms of action.
Determination of factors affecting probiotic viability in foods is also important as these will determine if their survival in the food, and therefore their delivery into the host, is maintained. This will constitute a quality control for functional foods.
The potential physiological effects of multiple prebiotic strains, as opposed to a single strain, are also interesting areas of research. The delivery of multiple probiotic strains may help ensure its effectiveness in an environment that contains high diversity of resident microflora. The potential benefits of synbiotics, (combination of probiotic and prebiotic) which have synergistic interaction, may also be investigated. A good combination will greatly enhance the health benefits to humans.
Extracellular vesicles (EVs) are traditionally classified into three types: exosomes (Exo), microvesicles (MVs), and apoptotic vesicles. Several theories exist on how tumor cells alter their neighboring cells and matrix ultimately changing their behavior into an invasive one. This typically would involve the transport of materials from tumor cells to their adjacent surroundings. These materials include a wide range of soluble cytokines, RNA species, enzymes, and proteins. Most of which are carried in nano-sized carriers such as EVs. EVs are classified according to their size and the mechanism of genesis. The first class of EVs known as MVs or when secreted from cancer cells, are called oncosomes [1]. MVs formation is originated by the outward budding of the cell surface at specific regions along the plasma membrane enriched with high concentrations of lipids, such as cholesterol and glycosphingolipids, and proteins such as Flotillin-1 and 2 [2]. Exo represent the second major class of EVs [3]. They are formed when multivesicular bodies (MVBs) in the endo-lysosomal pathway accumulate intraluminal vesicles (ILVs) that consist of proteins and nucleic acids. Exo are smaller in size and range from 30 to 50 nm.
EVs can function in an autocrine, paracrine, and even endocrine fashion, and were shown to impact various cancer cell phenotypes, increasing their cell growth and promoting metastasis [4]. This secretome is released into the microenvironment and acts as cell-cell communicators. Tumor derived Exo (TDE) has appeared as imperative facilitators in cancer initiation, progression, metastasis, host immune suppression, and drug resistance [5]. TDE typically consists of high sphingolipids and cholesterol contents that contain major histocompatibility complex (MHC) molecules, heat shock proteins, and tetraspanin (CD63, CD81, and CD9). Additionally, tumor antigens such as Mart1, gp100, TRP, and Her2-neu have been discovered in TDE [5]. TDE also contains surface and soluble proteins and RNA species such as mRNAs and miRNAs. mRNAs conveyed in EVs result in proteins synthesis in target cells, while miRNAs alter their gene expression [6]. The
Tumor development is a multistep process that starts by cellular reprogramming of cells to acquire the hallmarks of cancer cells to gain and maintain abnormal growth and invasive capacity [8]. The complex process of tumor formation and spreading additionally requires a rewiring of the surrounding stromal cells. This can be induced by intrinsic cell events such as genetic or epigenetic aberrations or by external factors from direct or indirect cell communication [9]. In cancer, EVs especially Exo, have been shown to be essential for various steps during tumor initiation and progression. EVs disrupt signaling and gene expression regulation in the recipient cell by horizontally transferring bioactive chemicals between cancer cells and the surrounding stroma. As a result, malignant cells can change the phenotype of surrounding benign cells to one that supports tumor growth and metastasis, creating a favorable environment for cancer progression and spread. EVs play several roles in priming the surrounding environment preparing it for metastasis and invasion. The role of EVs in promoting tumor progression has been elucidated in studies on mixed populations of EVs. The function of EVs largely depends on their bioactive cargo, in particular the shuttling of tumor-specific proteins to the surrounding cells. While researchers have mainly studied the RNA content of EVs, however, the focus is starting to shift towards the EVs proteome [10].
The protein content of MVs within mixed populations of EVs was discovered to be significantly diverse from that of the Exo proteome, and is supplemented in proteins involved in microtubule, actin, and cytoskeleton networks, ARF6, its effector phospholipase D2, and parts of the endosomal sorting complex required for transport family (ESCRT-I) [11]. By transporting these molecules, MVs can impact nearby tumor cells and stromal cells.
One example in which MVs shed by the cancer cells were shown to enhance tumor cell proliferation is in multiple myeloma. This effect was shown to be related to the amelioration of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147) on the tumor MVs. This protein is known to be overexpressed in solid tumors, some lymphomas, and leukemias [12]. Another study in breast cancer cells found that the highly glycosylated version of EMMPRIN exists in high quantities in breast cancer cell-derived MVs and enhances tumor invasion through activation of p38/MAPK signaling [11]. Interestingly, it was found that MVs from patient Blood with metastatic breast cancer had a similar high-EMMPRIN expression, along with the tumor marker Mucin-1 (MUC1/CA 15-3) [11]. Additionally, the truncated oncogenic form of the epidermal growth factor receptor (EGFR), EGFRvIII, commonly expressed in aggressive brain tumor cells, is associated with pro-tumorigenic tumor–tumor crosstalk via MVs. It was discovered that EGFRvIII was present in MVs released by U373 glioma cells, allowing them to transfer malignant features from highly aggressive tumor cells to the more benign tumor cells, EGFRvIII-negative, thereby facilitating their oncogenic transformation [11]. Hence, MVs are convenient communicators within the TME, as they can either mediate the horizontal transfer of oncogenic material or activate oncogenic signaling pathways in neighboring cancer cells, enhancing their survival, proliferative, and angiogenic potential and triggering their transformation into an aggressive phenotype.
Alongside the tumor–tumor communication, MVs were proven to facilitate the crosstalk between the tumor and its surrounding stroma and immune cells which ultimately leads to cancer immune evasion. In breast cancer cells, the secretion of both tumor MV and TDE induced the expression of Wnt5a in tumor-associated macrophages. Macrophage Wnt5a promoted ß-catenin-independent Wnt signaling in breast cancer cells when delivered by macrophage-derived MVs and Exo, resulting in enhanced tumor invasion. This shows how EV-based cell-cell communication can drive tumor-associated immune cells to stimulate tumor growth [11]. MVs-enriched preparations induced the differentiation of monocytes producing anti-inflammatory cytokines such as IL-10. In line with this, early stimulation with tumor MV triggered macrophage polarization towards an anti-inflammatory phenotype with decreased anti-tumor cytotoxic potential. Additionally, as T cells represent the first line of the immune defense, tumor cells appear to suppress T cell activity and diminish antitumoral immune response via MVs-mediated cell-cell communication. For instance, leukemia-derived MVs deliver miRNAs to T cells, which alters T cell phenotype [13] (Figure 1). Moreover, MVs released by irradiated breast cancer cells were shown to carry abundant immune-suppressive proteins, such as programmed cell death ligand 1 (PD-L1) which inhibited cytotoxic T cell activity and enabled tumor growth (Figure 1)[15].
Exosome PD-L1 (similar to tumor PD-L1) can bind to PD-1 on T cells, induce T cell apoptosis, and inhibit T cell activation and proliferation [
TDEs, through their miRNAs proteins, DNAs, mRNAs lncRNAs, initiate the transformation of epithelial cells to mesenchymal cells. This transformation was due to the loss of epithelial E-cadherin expression, cell-cell adhesion and cell polarity, and gaining of vimentin expression [16].
The complex and heterogeneous microenvironment of both primary or metastatic tumor is comprised of a network of cellular and acellular constituents. The cellular compartment consists of tumor cells and assorted non-transformed cells, such as cancer-associated fibroblasts (CAFs), macrophages, and endothelial cells. The non-cellular part is formed by secreted factors and components of the ECM. The tumor microenvironment modulates tumor progression by providing inhibitory or stimulatory growth signals [17]. Thus pre-metastatic niche refers to the microenvironment, that is primed to allow tumor cells to colonize in and disseminate to distant sites. The main machineries of the premetastatic niche formation include tumor-derived secreted factors (TDSFs), EVs bone marrow-derived cells (BMDCs), suppressive immune cells and host stromal cells [4], and inflammation. Chronic inflammation is a driving force for tumor development and metastasis. Thus, the local inflammatory microenvironment is one of the essential factors for the pre-metastatic niche formation and driving force for metastasis.
Tumor development and metastasis are aided by chronic inflammation. As a result, one of the most important variables in the establishment of a pre-metastatic niche is the local inflammatory microenvironment. Tumor cells can be induced to create TDSFs such as vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNF-α), transforming growth factor (TGF-β), and interleukin-2 by the local inflammatory microenvironment. These TDSFs then exert a paracrine effect on myeloid cells, initiating their migration to potential pre-metastatic niche formation sites [18]. Host stromal cells in the pre-metastatic niche may upregulate the expression of inflammatory factors in response to TDSF activation. The recruitment of BMDCs or immune cells to the pre-metastatic niche speeds up the release of inflammatory factors. Exo from tumors also transport inflammatory substances into the bloodstream, where they reach the pre-metastatic niche. In the pre-metastatic niche, an inflammatory milieu supportive to tumors is eventually generated [18].
In a study conducted by Hoshino, he showed that the proinflammatory cytokine s100 was upregulated up to four folds when Kupffer cells were treated with integrin intact Exo, as compared to those treated with integrin knocked out Exo. Hoshino speculated that the activation of Src, and its phosphorylation might be a causative pathway [19].
TDE and MV were also shown to modify fibroblasts in the tumor stroma. When normal human fibroblasts were exposed to oral squamous carcinoma derived MV [20] the fibroblasts were altered into a cancer phenotype. This switch to CAFs was largely mediated via metabolic reprogramming of the fibroblasts to aerobic glycolysis, with an increase in glucose uptake and lactate secretion. Some TDEs contain surface TGF-β along with betaglycan, which could trigger SMAD-dependent signaling and regulate the differentiation of fibroblasts to myofibroblasts [21]. This was further proved by co-culturing the generated CAF with cancer cells which led to enhanced cancer cell invasion and migration, creating a bidirectional cross-talk that favors tumor promotion and spread. The MVs-induced fibroblast activation and spreading seem to occur in the matrix milieu in the tumor periphery [22]. In prostate cancer, TDE were shown to induce the expression of RANKL and Metalloproteinases in CAFs, through miR-100, -21, and -139, further promoting its metastasis [23]. Hypoxia seems to stimulate prostate cancer cells to release protein-rich Exo which further induces activation of CAFs [24], promotes epithethelial mesenchymal transition (EMT), stemness, and angiogenesis by prostate cancer cells.
Additionally, TDE were also described as regulators of metabolism in the tumor microenvironment, for example, breast cancer tumors could suppress glucose uptake by lung fibroblasts, via secretion of Exo containing miR-122, increasing glucose availability and facilitating metastasis [25]. The cell-to-cell communication mediated by Exo is also affected by the genetic profile of the recipient fibroblasts. For example, fibroblasts lacking the BRCA1, a tumor suppressor gene, internalize larger amounts of serum-derived Exo when compared to BRCA1 containing fibroblasts [26]. Furthermore, these cells were found to undergo a malignant transformation when exposed to Exo derived from sera of cancer patients, implying that oncosuppressor genes can prevent exosome information from tumor cells from being integrated and thus shelter these cells from their pro-oncogenic signals [26].
Tumor MVs extravasate through the vessel wall in pancreatic cancer, reach the liver microcirculation and are picked up by perivascular macrophages to prime the liver metastatic niche in a CD36-dependent manner. Furthermore, tumor MVs produced from the B16F10 melanoma cell line was discovered to cause metastases in BALB/c mice, which are generally resistant to the B1610 tumor cell line [27]. TDEs also protect cancer cells from apoptosis by selectively effluxing apoptosis inducer proteins that are delivered by T cells or natural killer (NK) cells. TDEs also reduce the effects of therapy by preventing drug efflux or concealing the binding site of monoclonal antibodies, which could lead to the emergence of chemotherapy-resistant cell populations [28].
Exosome-derived programmed death receptor 1 (PD-1) and programmed death-ligand 1 have been linked to an immunological escape mechanism in recent years. PD-1 is mostly found on macrophages, activated T cells, and B cells, whereas PD-L1 is abundant in tumor tissues, antigen-presenting cells (APCs), and stromal cells [29]. T lymphocytes can recognize and destroy tumor cells in normal circumstances. When PD-1 attaches to PD-L1, however, it sends an inhibitory signal to T cells, causing them to die and inhibiting their activation and proliferation. As a result, blocking the PD-1/PD-L1 pathway may boost the immune response by increasing the killing effect of T cells [30]. T lymphocytes can recognize and destroy tumor cells in normal circumstances. When PD-1 attaches to PD-L1, however, it sends an inhibitory signal to T cells, causing them to die and inhibiting their activation and proliferation (Figure 1). As a result, blocking the PD-1/PD-L1 pathway may boost the immune response by increasing the killing effect of T cells. As a result, Exo containing PD-L1 suppress the immune system in the pre-metastatic milieu and promote the establishment of a pre-metastatic niche [31].
Angiogenesis within the primary tumor is also influenced by tumor MVs and TDE. Normal endothelial cells (ECs) were shown to endocytose tumor EVs, which triggered PI3K/Akt signaling and increased EC motility and tube formation ability [32]. Tumor MVs and TDE also release VEGF, a pro-angiogenic substance that stimulates ECs [33]. Similarly, MVs produced from multiple myeloma cells have been demonstrated to transfer CD138, a myeloma cell marker, to ECs, promoting their proliferation, invasion, and production of the angiogenic mediators IL-6 and VEGF, resulting in tube formation [50] (Figure 2). MVs change the environment around the main tumor and create pre-metastatic niches from afar. This was originally attributed to their procoagulant activity, which encouraged the production of microthrombi and facilitated the extravasation of trapped circulating tumor cells. ECs are important components of the tumor microenvironment because they provide a pathway for nutrients and trophic substances [34].
Possible mechanisms of pre-metastatic niche formation. The figure delineates how TDEs can modulate its surroundings of ECM, cancer-CAFs, immune cells, ECs, and MSCs all in favor of tumor support and progression. TDE can carry integrins to distant sites and create a pre-metastatic niche.
TDE enriched in vascular cell adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1 has been demonstrated to regulate the process of neovascularization in myeloid leukemia [35]. Furthermore, enhanced vascularization has been linked to the packaging of miR-92a in Exo derived from leukemia[36] and CO-029/D6.1A Tetraspanin in Exo produced from pancreatic cancer [37]. Upregulation of Heparanase in tumor cells, such as myeloma and breast malignancies, has also been linked to increased exosome production and exosomal packing of Syndecan-1, VEGF, and hepatocyte growth factor, resulting in enhanced endothelial invasion through the ECM [38]. Exo produced from skin cancer can also enhance angiogenesis by transferring the EGFR [39] and miR-9 to ECs [26]. Furthermore, melanoma-derived Exo have been found to condition sentinel lymph nodes prior to the installation of melanoma cells and subsequent metastasis by upregulating Collagen 18 and Laminin 5, as well as producing angiogenic growth factors [26].
Another significant component in altering tumor-EC communication is hypoxia. Hypoxic glioblastoma cells, for example, release Exo that interact with ECs, promoting proliferation and angiogenesis both in vitro and in vivo [40], and also prompting tissue factor/Factor VIIa dependent activation of hypoxic ECs [26].
Exo from melanoma cause pulmonary vascular leakiness and upregulate tumor cell recruitment genes such Stabilin 1, Vitronectin, Integrins, and Ephrin receptor b4 in lymph nodes, forming pre-metastatic niches [41]. Furthermore, breast cancer-derived Exo enriched in miR-105 alter the expression of Claudin 5, Zonula Occludens protein 1, and Occludin, which promotes metastasis by disrupting vascular endothelial barriers [42]. Exo produced from brain tumors include miR-181c, which regulates EC actin dynamics and promotes the breakdown of the blood-brain barrier by three times. Protein Kinase-1 Degradation Requires Phosphoinositol [43]. Similarly, glioblastoma cells release Exo with high quantities of VEGF-A, which promote EC permeability and angiogenesis in vitro [44].
TDE can promote pro-tumorigenic microenvironments via promoting tumor-stem/progenitor cell contact, in addition to its well-known actions in differentiated cells. Melanoma-derived Exo, for example, stimulate BMDCs by transferring the oncoprotein MET, resulting in the mobilization of vasculogenic and hematopoietic bone marrow progenitor cells to ensure vascular proliferation and immunosuppression at pre-metastatic niches [45]. Communication between tumor stem/progenitor cells is also critical in bone metastasis. Exo from bone metastatic prostate cancer PC3 cells were found to influence the process of bone metastasis by modulating both osteoclast genesis and osteoblast proliferation. Exo generated from osteoblasts, on the other hand, have been demonstrated to stimulate PC3 prostate cancer cell proliferation [46].
TDE was also demonstrated to influence the development of myeloid precursor cells into myeloid-derived suppressor cells (MDSCs), which are known to aid tumor progression by permitting immune escape [47]. Exo produced from breast carcinomas have been found to be taken up by bone marrow cells and to convert these cells’ development pathways toward MDSCs via Prostaglandin E2 and TGF-β, boosting COX2, IL6, VEGF, and Arginase1 accumulation by MDSCs [48].
TDE can also cause alterations in mesenchymal stem cells (MSCs), which help to promote and maintain tumor-promoting inflammatory environments. For example, HSP70+ lung tumor-derived exosomes (TDEs) activate NF-kB and cause MSCs to secrete IL-6, IL-8, and MCP1 via TLR2-mediated signaling, causing MSCs to become more inflammatory and tumor supportive [49]. According to De Veirman et al. [50], myeloma-derived Exo transfer miR-146a to mesenchymal cells, stimulating them to secrete numerous cytokines and chemokines including CXCL1, IL6, IL-8, IP-10, MCP-1, and CCL-5 (Figure 2). Another example is Exo produced by KMBC cholangiocarcinoma cells, which cause MSCs to upregulate IL-6, and hence KMBC cell proliferation [51].
One of the proposed mechanisms of tumorigenicity of TDE is the induction of tumor cell proliferation. Studies involving various cancer cells such as, chronic myeloid leukemia and in human gastric cancer, showed that this proliferative potential is via an autocrine induction through the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) and MAPK/ERK signaling pathways. Additionally, through the transference of lncRNAs (reviewed in [49]).
In addition, glioblastoma-derived Exo were shown to induce proliferation of the human glioma U87 cell line [40] in a mechanism dependent on the chloride intracellular channel protein 1 (CLIC1) [52]. In a more specific context linked to prostate cancer treatment, prostate cancer LNCaP cells grown in the presence of androgens generate Exo high in CD9, which enhance the growth of androgen-depleted LNCaP cells. Another example involves the promotion of in vivo growth of murine melanomas by systemic treatment of mice with melanoma-derived Exo, which accelerated growth and inhibited apoptosis of melanoma tumors in vivo [26].
TDE can alter the migratory behavior of recipient malignant cells. Exo produced from nasopharyngeal cancer-bearing EMT-inducing signals such as TGF-β and hypoxia-inducible factor 1 alpha (HIF1a) [53], matrix metalloproteinases (MMPs) Notch1, LMP1 Casein Kinase II and Annexin A2, were shown to enhance the migratory capacity of the tumor recipient cells. Another example involves Exo derived from hypoxic prostate cancer cells, which prompted invasiveness and motility of naïve human prostate cancer cells (reviewed in [26]) through the neighboring stroma and to nearby cells.
Exo have been found to have a role in tumor-tumor communication by transferring chemoresistance. Exo have been linked to the transfer of Docetaxel resistance in prostate cancer since Corcoran and colleagues first discovered it [54]. The transfer of cisplatin resistance in lung cancer is achieved by donor resistant cells producing Exo with low levels of miR-100-5p, which leads to enhanced expression of the mammalian target of rapamycin (mTOR) protein and chemoresistance in recipient cells [55].
MiRNA packed in Exo from drug-resistant cells can modulate the expression of specific target genes in breast cancer, such as miR-23a targeting Sprouty2, miR-222 targeting PTEN, miR-452 targeting APC4, and miR-24 targeting p27, thereby modulating chemoresistance in recipient cells that integrate these Exo. In fact, exosomal miR-222 plays a key role in this process, as the silencing of miR-221/222 prevents the transmission of resistance [56].
In addition to miRNAs, the transfer of exosomal mRNAs that encode drug-resistant proteins may result in chemoresistance in the receiving cell. GSTP1 exosomal mRNA from Adriamycin-resistant breast cancer cells, for example, confers resistance to previously susceptible cells. The presence of GSTP1 in circulating Exo from patients’ peripheral blood was linked to a worse outcome in breast cancer patients receiving Adriamycin [57]. A supporting stroma is required for an optimum metabolic and physiological environment for tumor growth. Fibroblasts are the most abundant cells in most solid tissues, participating in environmental cue responses and being a common target of tumor-derived signals [58].
Integrins are a wide family of cell adhesion receptor proteins such as alpha3beta1, alpha6beta1, alpha6beta4, and alpha7beta1. Their roles have been implicated in tumor metastasis and mesenchymal transformation. TDE carry these integrins from primary tumor sites to distant sites such as lung, lymph nodes, brain, and bone creating pre-metastatic niches (Figure 2) [59].
TDEs are involved in the advancement of several forms of cancer. Because of their abundance, TDEs may serve as noninvasive diagnostic and prognostic tools for various cancers. Additionally, blocking exosome secretion can slow the growth of some malignancies. Hence, Exo have been a popular target for developing cancer treatment techniques because of this property. Decreasing the expression of the exosomal proteins, Rab27a and Rab27b, inhibit exosome secretion without matching changes in soluble proteins secretions [60]. Several drugs used in the pharmaceutical industry such as Ketoconazole (an anti-fungal) sphingomyelinase (a hydrolase enzyme that is responsible for degrading sphingomyelin) [61], are additionally Rab27a inhibitors. These drugs can be re-directed as cancer modulators for their possible effects on attenuating TDE tumor progressive effects.
Furthermore, TDE owing to its small size, cancer-homing, and nontoxic nature, TDE can be re-directed to serve as a drug delivery system. Exo have been proven in several investigations to act as drug delivery vehicles, transporting anti-cancer chemicals to target cells [62]. For example, adriamycin and paclitaxel, target cancer cells via exosomal encapsulation and have low toxicity and immunogenicity [63].
EVs modulate the environment that favors tumor growth and progression. EVs provide a method of cell-cell communication, and through their rich cargo of ECM proteins, cell adhesion proteins, tyrosine kinases, chaperones, signaling proteins, DNA and RNA binding proteins, they create a pre-metastatic niche. By priming nearby and distant cells into becoming cancerous, they promote tumor metastasis. Several mechanisms have been discovered for their actions including, promotion of migratory behavior, chemoresistance, anti-apoptosis, vascular leakage, and immune modulation. Understanding how TDE and MVs create a pre-metastatic niche and how halting the trafficking of such vesicles can produce a revolutionizing new era in the field of cancer therapeutics. By preventing TDE-promoted metastasis and tumor progression, coupled with conventional radio and chemotherapy, the survival rates of cancer patients can significantly improve.
The author declares no conflicts of interest.
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',metaTitle:"Terms and Conditions",metaDescription:"These terms and conditions outline the rules and regulations for the use of IntechOpen Website at https://intechopen.com and all its subdomains owned by Intech Limited located at 7th floor, 10 Lower Thames Street, London, EC3R 6AF, UK.",metaKeywords:null,canonicalURL:"/page/terms-and-conditions",contentRaw:'[{"type":"htmlEditorComponent","content":"By accessing the website at www.intechopen.com you are agreeing to be bound by these Terms of Service, all applicable laws and regulations, and agree that you are responsible for compliance with any applicable local laws. Use and/or access to this site is based on full agreement and compliance of these Terms. All materials contained on this website are protected by applicable copyright and trademark laws.
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\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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Lopez",coverURL:"https://cdn.intechopen.com/books/images_new/2221.jpg",editedByType:"Edited by",editors:[{id:"146976",title:"Dr.",name:"Gloria",middleName:"I.",surname:"López",slug:"gloria-lopez",fullName:"Gloria López"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:7,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"64510",doi:"10.5772/intechopen.82320",title:"Introductory Chapter: Morphodynamic Model for Predicting Beach Changes Based on Bagnold’s Concept and Its Applications",slug:"introductory-chapter-morphodynamic-model-for-predicting-beach-changes-based-on-bagnold-s-concept-and",totalDownloads:894,totalCrossrefCites:13,totalDimensionsCites:15,abstract:null,book:{id:"6012",slug:"morphodynamic-model-for-predicting-beach-changes-based-on-bagnold-s-concept-and-its-applications",title:"Morphodynamic Model for Predicting Beach Changes Based on Bagnold's Concept and Its Applications",fullTitle:"Morphodynamic Model for Predicting Beach Changes Based on Bagnold's Concept and Its Applications"},signatures:"Takaaki Uda, Masumi Serizawa and Shiho Miyahara",authors:[{id:"13491",title:"Dr.",name:"Takaaki",middleName:null,surname:"Uda",slug:"takaaki-uda",fullName:"Takaaki Uda"}]},{id:"67923",doi:"10.5772/intechopen.87843",title:"Structure and Dynamics of Plumes Generated by Small Rivers",slug:"structure-and-dynamics-of-plumes-generated-by-small-rivers",totalDownloads:862,totalCrossrefCites:6,totalDimensionsCites:13,abstract:"The total share of small rivers in the influxes of fluvial water and suspended matter to the world ocean is estimated at between 25 and 40%. On a regional scale, this contribution can be even more significant for many coastal regions. In this chapter, we show that dynamics of small river plumes is significantly different from that of plumes generated by large rivers. Spatial structure of small plumes is generally characterized by sharper horizontal and vertical gradients. As a result, small plumes exhibit more energetic temporal variability in response to external forcing. In this chapter, we address several dynamical features typical for small plumes. We describe and discuss the response of small plumes to wind forcing and river discharge variability, the interaction between neighboring small plumes, and the generation of high-frequency internal waves in coastal ocean by small rivers. We also substantiate the Lagrangian approach to numerical modeling of small river plumes.",book:{id:"8007",slug:"estuaries-and-coastal-zones-dynamics-and-response-to-environmental-changes",title:"Estuaries and Coastal Zones",fullTitle:"Estuaries and Coastal Zones - Dynamics and Response to Environmental Changes"},signatures:"Alexander Osadchiev and Peter Zavialov",authors:[{id:"296909",title:"Prof.",name:"Peter",middleName:null,surname:"Zavialov",slug:"peter-zavialov",fullName:"Peter Zavialov"},{id:"296910",title:"Dr.",name:"Alexander",middleName:null,surname:"Osadchiev",slug:"alexander-osadchiev",fullName:"Alexander Osadchiev"}]},{id:"41072",doi:"10.5772/51864",title:"The November, 1st, 1755 Tsunami in Morocco: Can Numerical Modeling Clarify the Uncertainties of Historical Reports?",slug:"the-november-1st-1755-tsunami-in-morocco-can-numerical-modeling-clarify-the-uncertainties-of-histori",totalDownloads:2407,totalCrossrefCites:4,totalDimensionsCites:10,abstract:null,book:{id:"2221",slug:"tsunami-analysis-of-a-hazard-from-physical-interpretation-to-human-impact",title:"Tsunami - Analysis of a Hazard",fullTitle:"Tsunami - Analysis of a Hazard - From Physical Interpretation to Human Impact"},signatures:"R. Omira, M.A. Baptista, S. Mellas, F. Leone, N. Meschinet de Richemond, B. Zourarah and J-P. Cherel",authors:[{id:"16693",title:"Prof.",name:"Maria Ana",middleName:null,surname:"Baptista",slug:"maria-ana-baptista",fullName:"Maria Ana Baptista"},{id:"16695",title:"Dr.",name:"Rachid",middleName:null,surname:"Omira",slug:"rachid-omira",fullName:"Rachid Omira"},{id:"92702",title:"Prof.",name:"Frederic",middleName:null,surname:"Leone",slug:"frederic-leone",fullName:"Frederic Leone"},{id:"148352",title:"MSc.",name:"Samira",middleName:null,surname:"Mellas",slug:"samira-mellas",fullName:"Samira Mellas"},{id:"148353",title:"Prof.",name:"Bendahou",middleName:null,surname:"Zourarah",slug:"bendahou-zourarah",fullName:"Bendahou Zourarah"},{id:"148356",title:"Prof.",name:"Jean-Philippe",middleName:null,surname:"Cherel",slug:"jean-philippe-cherel",fullName:"Jean-Philippe Cherel"},{id:"157593",title:"Prof.",name:"Nancy",middleName:null,surname:"Meschinet De Richemond",slug:"nancy-meschinet-de-richemond",fullName:"Nancy Meschinet De Richemond"}]},{id:"58729",doi:"10.5772/intechopen.73217",title:"Spatio-Temporal Analysis of Sea Surface Temperature in the East China Sea Using TERRA/MODIS Products Data",slug:"spatio-temporal-analysis-of-sea-surface-temperature-in-the-east-china-sea-using-terra-modis-products",totalDownloads:1054,totalCrossrefCites:3,totalDimensionsCites:8,abstract:"Sea surface temperature (SST) is an important parameter in determining the atmospheric and oceanic circulations, and satellite thermal infrared remote sensing can obtain the SST with very high spatio-temporal resolutions. The study first validated the accuracy of TERRA MODIS SST daytime and nighttime products with the timing SST measurements from the ships in the East China Sea (ECS) in February, May, August and November, 2001, and then the daily variation of daytime and nighttime SST difference was analyzed. Using 16-year MODIS SST monthly products data from February 2000 to January 2016, when all SST monthly products in February, May, August and November were averaged respectively, the seasonal spatial distribution pattern of SST in the ECS was discovered. After monthly sea surface temperature anomaly was finally processed by the empirical orthogonal function (EOF), the interannual variability of SST in the ECS was discussed. The results show that the MODIS SST daily products have a good accuracy with a mean absolute percentage error (MAPE) below 5%. The SST difference between day and night is the largest in winter, followed by spring, then for autumn and the smallest in summer, while the diurnal SST difference is very low for the same season in the different seas. The SST in the ECS displays the obvious seasonal spatial distribution pattern, in which the SST of winter is gradually increasing from north to south, while local temperature difference is the largest for 26.5°C in a year. In comparison, the SST in summer tends uniform and the difference is not more than 5°C in the whole sea. From the EOF analysis of SST anomaly, the interannual variability of SST in the ECS is affected by the East Asian monsoon, the latitudinal difference of solar radiation, the offshore circulation and the submarine terrain.",book:{id:"6195",slug:"sea-level-rise-and-coastal-infrastructure",title:"Sea Level Rise and Coastal Infrastructure",fullTitle:"Sea Level Rise and Coastal Infrastructure"},signatures:"Shaoqi Gong and Kapo Wong",authors:[{id:"219135",title:"Dr.",name:"Shaoqi",middleName:null,surname:"Gong",slug:"shaoqi-gong",fullName:"Shaoqi Gong"},{id:"219138",title:"Mr.",name:"Wong",middleName:null,surname:"Kapo",slug:"wong-kapo",fullName:"Wong Kapo"}]},{id:"63609",doi:"10.5772/intechopen.80903",title:"Saltwater Intrusion in the Changjiang Estuary",slug:"saltwater-intrusion-in-the-changjiang-estuary",totalDownloads:1460,totalCrossrefCites:3,totalDimensionsCites:7,abstract:"Saltwater intrusion in the Changjiang Estuary and the impacts of river discharge, tide, wind, sea level rise, river basin, and major estuary projects on saltwater intrusion are studied in this chapter. There is a net landward flow in the NB (North Branch) when river discharge is low during spring tide, resulting in a type of saltwater intrusion known as the SSO (saltwater-spilling-over from the NB into the SB (South Branch)), which is the most striking characteristic of saltwater intrusion in the estuary. A three-dimension numerical model with HSIMT-TVD advection scheme was developed to study the hydrodynamic processes and saltwater intrusion in the Changjiang Estuary. Saltwater intrusion in the estuary is controlled mainly by river discharge and tide, but is also influenced by wind, sea level rise, river basin, and estuary projects. Saltwater intrusion is enhanced when river discharge decreases. There is more time for the reservoir to take freshwater from the river when river discharge is larger. The fortnightly spring tide generates greater saltwater intrusion than the neap tide. The saltwater intrusion in the SP (South Passage) is stronger than that in the NP (North Passage), and the intrusion in the NP is stronger than that in the NC (North Channel). The northerly wind produces southward currents along the Subei coast as well as the landward Ekman transport, which enhances the saltwater intrusion in the NC and NB and weakens the saltwater intrusion in the NP and SP. Saltwater intrusion becomes stronger as the sea level rises and is much stronger when river discharge is much small. The DWP (Deep Waterway Project) alleviates the saltwater intrusion in the NC and the lower reaches of the NP and enhances the saltwater intrusion in the SP and in the upper reaches of the NP. The Three Gorges Dam (TGD) increases river discharge in winter, which weakens saltwater intrusion, and is favorable for reducing the burden of freshwater supplement in the highly populated estuarine region. The Water Diversion South to the North Project (WDP) decreases river discharge, enhances saltwater intrusion, and is unfavorable for freshwater supply in the estuary.",book:{id:"8669",slug:"coastal-environment-disaster-and-infrastructure-a-case-study-of-china-s-coastline",title:"Coastal Environment, Disaster, and Infrastructure",fullTitle:"Coastal Environment, Disaster, and Infrastructure - A Case Study of China's Coastline"},signatures:"Jianrong Zhu, Hui Wu, Lu Li and Cheng Qiu",authors:[{id:"266207",title:"Dr.",name:"Jianrong",middleName:null,surname:"Zhu",slug:"jianrong-zhu",fullName:"Jianrong Zhu"}]}],mostDownloadedChaptersLast30Days:[{id:"70994",title:"Circulations in the Pearl River Estuary: Observation and Modeling",slug:"circulations-in-the-pearl-river-estuary-observation-and-modeling",totalDownloads:794,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"This chapter reports a cruise survey on the Pearl River Estuary (PRE) and adjacent costal water in the period between May 3, 2014 and May 11, 2014. The circulation and salinity structure were sampled for different tidal phases. With the cruise data, a “sandwich” structure of the lateral salinity distribution and a two-layer structure of longitudinal circulation were identified, together with high variations influenced by wind and tide. Furthermore, longitudinally orientated convergence or divergence of the lateral velocity close to the channel location for certain tidal conditions was observed. The finite volume community ocean model (FVCOM) is configured and run with high spatial resolution of 100 m in the PRE. An atmospheric model, the Weather Research and Forecasting (WRF) Model, is also run to provide high spatial and temporal resolution of atmospheric forcing for the FVCOM. The FVCOM modeling skill assessment is conducted using the cruise salinity and velocity data, as well as water levels, showing that the model can well simulate the velocity and salinity structures. The numerical model reveals that there is a strong neap-spring cycle for the PRE de-tided circulation with 0.37 m s−1 during the neap tide about 42% stronger than that (0.26 m s−1) during the spring tide in the surface layer.",book:{id:"8007",slug:"estuaries-and-coastal-zones-dynamics-and-response-to-environmental-changes",title:"Estuaries and Coastal Zones",fullTitle:"Estuaries and Coastal Zones - Dynamics and Response to Environmental Changes"},signatures:"Jiayi Pan, Wenfeng Lai and Adam Thomas Devlin",authors:[{id:"280757",title:"Dr.",name:"Adam",middleName:"Thomas",surname:"Devlin",slug:"adam-devlin",fullName:"Adam Devlin"},{id:"302219",title:"Associate Prof.",name:"Jiayi",middleName:null,surname:"Pan",slug:"jiayi-pan",fullName:"Jiayi Pan"},{id:"309888",title:"Dr.",name:"Wenfeng",middleName:null,surname:"Lai",slug:"wenfeng-lai",fullName:"Wenfeng Lai"}]},{id:"41072",title:"The November, 1st, 1755 Tsunami in Morocco: Can Numerical Modeling Clarify the Uncertainties of Historical Reports?",slug:"the-november-1st-1755-tsunami-in-morocco-can-numerical-modeling-clarify-the-uncertainties-of-histori",totalDownloads:2407,totalCrossrefCites:4,totalDimensionsCites:10,abstract:null,book:{id:"2221",slug:"tsunami-analysis-of-a-hazard-from-physical-interpretation-to-human-impact",title:"Tsunami - Analysis of a Hazard",fullTitle:"Tsunami - Analysis of a Hazard - From Physical Interpretation to Human Impact"},signatures:"R. Omira, M.A. Baptista, S. Mellas, F. Leone, N. Meschinet de Richemond, B. Zourarah and J-P. Cherel",authors:[{id:"16693",title:"Prof.",name:"Maria Ana",middleName:null,surname:"Baptista",slug:"maria-ana-baptista",fullName:"Maria Ana Baptista"},{id:"16695",title:"Dr.",name:"Rachid",middleName:null,surname:"Omira",slug:"rachid-omira",fullName:"Rachid Omira"},{id:"92702",title:"Prof.",name:"Frederic",middleName:null,surname:"Leone",slug:"frederic-leone",fullName:"Frederic Leone"},{id:"148352",title:"MSc.",name:"Samira",middleName:null,surname:"Mellas",slug:"samira-mellas",fullName:"Samira Mellas"},{id:"148353",title:"Prof.",name:"Bendahou",middleName:null,surname:"Zourarah",slug:"bendahou-zourarah",fullName:"Bendahou Zourarah"},{id:"148356",title:"Prof.",name:"Jean-Philippe",middleName:null,surname:"Cherel",slug:"jean-philippe-cherel",fullName:"Jean-Philippe Cherel"},{id:"157593",title:"Prof.",name:"Nancy",middleName:null,surname:"Meschinet De Richemond",slug:"nancy-meschinet-de-richemond",fullName:"Nancy Meschinet De Richemond"}]},{id:"63921",title:"Eight Types of BG Models and Discretization",slug:"eight-types-of-bg-models-and-discretization",totalDownloads:953,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Eight types of the BG models are introduced in this chapter. The Type 1 is a model using wave parameters at the breaking point. In the Type 2, the effect of longshore sand transport due to the effect of the longshore gradient of breaker height is included with an additional term given by Ozasa and Brampton. In the Type 3, the intensity of sand transport P is assumed to be proportional to the third power of the amplitude of the bottom oscillatory velocity um due to waves, and in the Type 4, P is given by the wave energy dissipation rate due to wave breaking at a local point. In the Type 5, wave power is calculated using the coordinate system different from that for the calculation of beach changes to predict the topographic changes of an island or a cuspate foreland in a shallow water body under the action of waves randomly incident from every direction. In the Type 6, the height of wind waves is predicted using Wilson’s formula using the wind fetch distance and wind velocity, and then sand transport fluxes are calculated. The Type 7 is a model for predicting the formation of the ebb-tidal delta under the combined effect of waves and ebb-tidal currents with an analogy of the velocity distribution of ebb-tidal currents to the wave diffraction coefficient, which can be calculated by the angular spreading method for irregular waves. In the Type 8, the effect of the nearshore currents induced by forced wave breaking is incorporated into the model by calculating the nearshore currents, taking both the wave field and the current velocity at a local point into account.",book:{id:"6012",slug:"morphodynamic-model-for-predicting-beach-changes-based-on-bagnold-s-concept-and-its-applications",title:"Morphodynamic Model for Predicting Beach Changes Based on Bagnold's Concept and Its Applications",fullTitle:"Morphodynamic Model for Predicting Beach Changes Based on Bagnold's Concept and Its Applications"},signatures:"Takaaki Uda, Masumi Serizawa and Shiho Miyahara",authors:[{id:"13491",title:"Dr.",name:"Takaaki",middleName:null,surname:"Uda",slug:"takaaki-uda",fullName:"Takaaki Uda"}]},{id:"57606",title:"Analysis of Dynamic Effects on the Brazilian Vertical Datum",slug:"analysis-of-dynamic-effects-on-the-brazilian-vertical-datum",totalDownloads:961,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"This chapter presents a methodology of analyzing the dynamic effect from mean sea level variations, based on Global Navigation Satellite System (GNSS) data, velocity models, tide gauge observations, and satellite altimetry data. GNSS observations were processed in order to obtain the variation of up coordinate required to identify the possible crust movements. Velocity model served as a comparative basis to verify the obtained results from the GNSS data processing and served as a basis for analyzing the time periods without GNSS information. Tide gauge data were used to evaluate the sea level temporal evolution in the Imbituba Brazilian Vertical Datum (I-BVD). Satellite altimetry data were used for checking the results from the GNSS and the tide gauge time series. The analyses were based on time series of observations by GNSS from 2007 until 2016, tide gauge from 1948 until 1968 and 2001 until 2016, and satellite altimetry data from 1991 until 2015 from different missions. As basis for the analysis, it used GNSS SIRGAS-CON stations, the SIRGAS velocity model (VEMOS), and NUVEL velocity model. Considering the discrimination of the crust vertical movement (GNSS processing) from the results obtained with the tide gauge observations, it was observed that there is an evidence of mean sea level (MSL) rising approximately +2.24 ± 0.4 mm/year.",book:{id:"6195",slug:"sea-level-rise-and-coastal-infrastructure",title:"Sea Level Rise and Coastal Infrastructure",fullTitle:"Sea Level Rise and Coastal Infrastructure"},signatures:"Luciana M. Da Silva, Sílvio R.C. De Freitas and Regiane Dalazoana",authors:[{id:"208387",title:"Dr.",name:"Luciana",middleName:"Maria",surname:"Da Silva",slug:"luciana-da-silva",fullName:"Luciana Da Silva"},{id:"209224",title:"Dr.",name:"Sílvio",middleName:null,surname:"De Freitas",slug:"silvio-de-freitas",fullName:"Sílvio De Freitas"},{id:"209225",title:"Dr.",name:"Regiane",middleName:null,surname:"Dalazoana",slug:"regiane-dalazoana",fullName:"Regiane Dalazoana"}]},{id:"58909",title:"Coastal Disasters and Remote Sensing Monitoring Methods",slug:"coastal-disasters-and-remote-sensing-monitoring-methods",totalDownloads:1133,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Coastal disaster is abnormal changes caused by climate change, human activities, geological movement or natural environment changes. According to formation cause, marine disasters as storm surges, waves, Tsunami coastal erosion, sea-level rise, red tide, seawater intrusion, marine oil spill and soil salinization. Remote sensing technology has real-time and large-area advantages in promoting the monitoring and forecast ability of coastal disaster. Relative to natural disasters, ones caused by human factors are more likely to be monitored and prevented. In this paper, we use several remote sensing methods to monitor or forecast three kinds of coastal disaster cause by human factors including red tide, sea-level rise and oil spilling, and make proposals for infrastructure based on the research results. The chosen method of monitoring red tide by inversing chlorophyll-a concentration is improved OC3M Model, which is more suitable for the coastal zone and higher spatial resolution than the MODIS chlorophyll-a production. We monitor the sea-level rise in coastal zone through coastline changes without artificial modifications. The improved Lagrangian model can simulate the trajectory of oil slick efficiently. Making the infrastructure planning according the coastal disasters and features of coastline contributes to prevent coastal disaster and coastal ecosystem protection. Multi-source remote sensing data can effectively monitor and prevent coastal disaster, and provide planning advices for coastal infrastructure construction.",book:{id:"6195",slug:"sea-level-rise-and-coastal-infrastructure",title:"Sea Level Rise and Coastal Infrastructure",fullTitle:"Sea Level Rise and Coastal Infrastructure"},signatures:"Yan Yu, Shengbo Chen, Tianqi Lu and Siyu Tian",authors:[{id:"162887",title:"Prof.",name:"Shengbo",middleName:null,surname:"Chen",slug:"shengbo-chen",fullName:"Shengbo Chen"},{id:"220026",title:"Dr.",name:"Yan",middleName:null,surname:"Yu",slug:"yan-yu",fullName:"Yan Yu"}]}],onlineFirstChaptersFilter:{topicId:"839",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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",coverUrl:"https://cdn.intechopen.com/series/covers/22.jpg",latestPublicationDate:"June 27th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"356540",title:"Prof.",name:"Taufiq",middleName:null,surname:"Choudhry",slug:"taufiq-choudhry",fullName:"Taufiq Choudhry",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000036X2hvQAC/Profile_Picture_2022-03-14T08:58:03.jpg",biography:"Prof. Choudhry holds a BSc degree in Economics from the University of Iowa, as well as a Masters and Ph.D. in Applied Economics from Clemson University, USA. In January 2006, he became a Professor of Finance at the University of Southampton Business School. He was previously a Professor of Finance at the University of Bradford Management School. He has over 80 articles published in international finance and economics journals. His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"89",title:"Education",coverUrl:"https://cdn.intechopen.com/series_topics/covers/89.jpg",isOpenForSubmission:!1,editor:{id:"260066",title:"Associate Prof.",name:"Michail",middleName:null,surname:"Kalogiannakis",slug:"michail-kalogiannakis",fullName:"Michail Kalogiannakis",profilePictureURL:"https://mts.intechopen.com/storage/users/260066/images/system/260066.jpg",biography:"Michail Kalogiannakis is an Associate Professor of the Department of Preschool Education, University of Crete, and an Associate Tutor at School of Humanities at the Hellenic Open University. He graduated from the Physics Department of the University of Crete and continued his post-graduate studies at the University Paris 7-Denis Diderot (D.E.A. in Didactic of Physics), University Paris 5-René Descartes-Sorbonne (D.E.A. in Science Education) and received his Ph.D. degree at the University Paris 5-René Descartes-Sorbonne (PhD in Science Education). His research interests include science education in early childhood, science teaching and learning, e-learning, the use of ICT in science education, games simulations, and mobile learning. He has published over 120 articles in international conferences and journals and has served on the program committees of numerous international conferences.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorTwo:{id:"422488",title:"Dr.",name:"Maria",middleName:null,surname:"Ampartzaki",slug:"maria-ampartzaki",fullName:"Maria Ampartzaki",profilePictureURL:"https://mts.intechopen.com/storage/users/422488/images/system/422488.jpg",biography:"Dr Maria Ampartzaki is an Assistant Professor in Early Childhood Education in the Department of Preschool Education at the University of Crete. Her research interests include ICT in education, science education in the early years, inquiry-based and art-based learning, teachers’ professional development, action research, and the Pedagogy of Multiliteracies, among others. She has run and participated in several funded and non-funded projects on the teaching of Science, Social Sciences, and ICT in education. She also has the experience of participating in five Erasmus+ projects.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorThree:null},{id:"90",title:"Human Development",coverUrl:"https://cdn.intechopen.com/series_topics/covers/90.jpg",isOpenForSubmission:!0,editor:{id:"191040",title:"Dr.",name:"Tal",middleName:null,surname:"Dotan Ben-Soussan",slug:"tal-dotan-ben-soussan",fullName:"Tal Dotan Ben-Soussan",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBf1QAG/Profile_Picture_2022-03-18T07:56:11.jpg",biography:"Tal Dotan Ben-Soussan, Ph.D., is the director of the Research Institute for Neuroscience, Education and Didactics (RINED) – Paoletti Foundation. Ben-Soussan leads international studies on training and neuroplasticity from neurophysiological and psychobiological perspectives. As a neuroscientist and bio-psychologist, she has published numerous articles on neuroplasticity, movement and meditation. She acts as an editor and reviewer in several renowned journals and coordinates international conferences integrating theoretical, methodological and practical approaches on various topics, such as silence, logics and neuro-education. She lives in Assisi, Italy.",institutionString:"Research Institute for Neuroscience, Education and Didactics, Patrizio Paoletti Foundation",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:5,paginationItems:[{id:"82394",title:"Learning by Doing Active Social Learning",doi:"10.5772/intechopen.105523",signatures:"Anat Raviv",slug:"learning-by-doing-active-social-learning",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"82310",title:"Knowledge of Intergenerational Contact to Combat Ageism towards Older People",doi:"10.5772/intechopen.105592",signatures:"Alice Nga Lai Kwong",slug:"knowledge-of-intergenerational-contact-to-combat-ageism-towards-older-people",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Social Aspects of Ageing - 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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. 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In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. 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He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. from Integral University, Lucknow, India, with his work titled ‘Development and evaluation of silymarin nanoformulation for hepatic carcinoma’. Currently, he is an Assistant Professor of Pharmaceutics, at the Faculty of Pharmacy, Integral University. He has been teaching PharmD, BPharm, and MPharm students and conducting research in the novel drug delivery domain. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than twenty-four original journal articles, two edited books, four book chapters, and several scientific articles to his credit. He is a member of the American Association for Cancer Research, the International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}}]}},subseries:{item:{id:"4",type:"subseries",title:"Fungal Infectious Diseases",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11400,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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