Open access peer-reviewed Edited volume

Toxicity and Drug Testing

Modern drug design and testing involves experimental in vivo and in vitro measurement of the drug candidate's ADMET (adsorption, distribution, metabolism, elimination and toxicity) properties in the early stages of drug discovery. Only a small percentage of the proposed drug candidates receive government approval and reach the market place. Unfavorable pharmacokinetic properties, poor bioavailability and efficacy, low solubility, adverse side effects and toxicity concerns account for many of the drug failures encountered in the pharmaceutical industry. Authors from several countries have contributed chapters detailing regulatory policies, pharmaceutical concerns and clinical practices in their respective countries with the expectation that the open exchange of scientific results and ideas presented in this book will lead to improved pharmaceutical products.

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Toxicity and Drug TestingEdited by Bill Acree

Published: February 10th 2012

DOI: 10.5772/1976

ISBN: 978-953-51-0004-1

Copyright year: 2012

Books open for chapter submissions

106309 Total Chapter Downloads

25 Crossref Citations

79 Web of Science Citations

104 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Blood Brain Barrier Permeation

By Abolghasem Jouyban and Somaieh Soltani

6298

Open access peer-reviewed

2. Diagnostic Accuracy and Interpretation of Urine Drug Testing for Pain Patients: An Evidence-Based Approach

By Amadeo Pesce, Cameron West, Kathy Egan-City and William Clarke

5453

Open access peer-reviewed

3. Experimental and Computational Methods Pertaining to Surface Tension of Pharmaceuticals

By Abolghasem Jouyban and Anahita Fathi-Azarbayjan

4843

Open access peer-reviewed

4. Multi-Well Engineered Heart Tissue for Drug Screening and Predictive Toxicology

By Alexandra Eder, Arne Hansen and Thomas Eschenhagen

1673

Open access peer-reviewed

5. Prediction of Partition Coefficients and Permeability of Drug Molecules in Biological Systems with Abraham Model Solute Descriptors Derived from Measured Solubilities and Water-to-Organic Solvent Partition Coefficients

By William E. Acree, Jr., Laura M. Grubbs and Michael H. Abraham

8418

Open access peer-reviewed

6. Variability of Plasma Methadone Concentration in Opiate Dependent Receiving Methadone: A Personalised Approach Towards Optimizing Dose

By Nasir Mohamad, Nor Hidayah Abu Bakar, Tan Soo Choon, Sim Hann Liang, NIM Nazar, Ilya Irinaz Idrus and Rusli Ismail

1784

Open access peer-reviewed

7. Drug Synergy – Mechanisms and Methods of Analysis

By Hans-Georg Breitinger

13689

Open access peer-reviewed

8. Herbal Medicine in the Treatment of Malaria: Vernonia amygdalina: An Overview of Evidence and Pharmacology

By Anoka A. Njan

3502

Open access peer-reviewed

9. Experimental and Computational Methods Pertaining to Drug Solubility

By Abolghasem Jouyban and Mohammad A. A. Fakhree

5800

Open access peer-reviewed

10. Toxic Effects of Cadmium on Crabs and Shrimps

By Xianjiang Kang, Shumei Mu, Wenyan Li and Na Zhao

2904

Open access peer-reviewed

11. Paraquat, Between Apoptosis and Autophagy

By Rosa A. González-Polo, José M. Bravo-San Pedro, Rubén Gómez-Sánchez, Elisa Pizarro-Estrella, Mireia Niso-Santano and José M. Fuentes

2071

Open access peer-reviewed

12. Prediction of Toxicity, Sensory Responses and Biological Responses with the Abraham Model

By William E. Acree, Jr., Laura M. Grubbs and Michael H. Abraham

2953

Open access peer-reviewed

13. Mikania glomerata and M. laevigata: Clinical and Toxicological Advances

By João Cleverson Gasparetto, Roberto Pontarolo, Thais M. Guimarães de Francisco and Francinete Ramos Campos

2550

Open access peer-reviewed

14. Evaluation of Drug Toxicity for DNA Vaccine Candidates Against Infectious Diseases: Hepatitis C as Experimental Model

By Dania Bacardí, Karelia Cosme, José Suárez, Yalena Amador-Cañizares and Santiago Dueñas-Carrera

1829

Open access peer-reviewed

15. Aluminium Phosphide Poisoning

By Babak Mostafazadeh

9396

Open access peer-reviewed

16. Application of a New Genotoxicity Test System with Human Hepatocyte Cell Lines to Improve the Risk Assessment in the Drug Development

By Tsuneo Hashizume and Hiroaki Oda

2255

Open access peer-reviewed

17. Genotoxic Impurities in Pharmaceuticals

By Abolghasem Jouyban and Hamed Parsa

22175

Open access peer-reviewed

18. Measurement Uncertainty in Forensic Toxicology: Its Estimation, Reporting and Interpretation

By Rod G. Gullberg

3491

Open access peer-reviewed

19. Toxicokinetics and Organ-Specific Toxicity

By P.D. Ward

1668

Open access peer-reviewed

20. Environmental Toxicants Induced Male Reproductive Disorders: Identification and Mechanism of Action

By Kuladip Jana and Parimal C. Sen

3557

Edited volume and chapters are indexed in

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