Open access peer-reviewed Edited Volume


The Hormone of Darkness and its Therapeutic Potential and Perspectives

Edited by Marilena Vlachou

National and Kapodistrian University of Athens

This book, on the pineal hormone melatonin, is addressed to a wide non-cognizant and cognizant readership. The hormone appears to be involved in sleep onset and other functions associated with the body’s clock, the suprachiasmic nucleus. It is ubiquitous throughout both the animal and plant kingdoms and has a long evolutionary history as a hormone. Melatonin has a major role in the regulation of circadian rhythms in non-mammalian vertebrates and forms part of their control in mammals. The present text emphasizes the positive role of exogenously administered melatonin, and its synthetic derivatives, on disrupted circadian rhythm-related dysfunctions. This is effected by resetting the clock in jet lag sufferers and those with seasonal affective disorders, insomnia, and various neurological conditions.

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MelatoninThe Hormone of Darkness and its Therapeutic Potential and PerspectivesEdited by Marilena Vlachou

Published: June 24th 2020

DOI: 10.5772/intechopen.80180

ISBN: 978-1-83962-909-9

Print ISBN: 978-1-83962-908-2

eBook (PDF) ISBN: 978-1-83962-910-5

Copyright year: 2020

Books open for chapter submissions

3050 Total Chapter Downloads

1 Crossref Citations

1 Web of Science Citations

2 Dimensions Citations


Open access peer-reviewed

1. Synthetic Melatonin Receptor Agonists and Antagonists

By Andrew Tsotinis and Ioannis P. Papanastasiou


Open access peer-reviewed

2. Clinical Use of Melatonin in the Treatment of Sleep Disorders

By Alexander Zakharov and Elena Khivintseva


Open access peer-reviewed

3. Melatonin as a Food Supplement for Sleep Disorders

By Ioulia K. Tseti


Open access peer-reviewed

4. Melatonin for a Healthy Heart Rhythm

By Natalia Jorgelina Prado, Margarita Segovia-Roldan, Emiliano Raúl Diez and Esther Pueyo


Open access peer-reviewed

5. Per Os Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach

By Angeliki Siamidi and Yannis Dotsikas


Open access peer-reviewed

6. The Release Kinetics of Melatonin from Innovative Dosage Forms: The Role of the Fractal Geometry of the “Vehicle”

By Natassa Pippa and Costas Demetzos


Open access peer-reviewed

7. Review of Melatonin in Horticultural Crops

By Yanyan Yan, Qinghua Shi and Biao Gong


Open access peer-reviewed

8. Studies on Tryptophan Metabolites in Patients of Major Monopolar Depression

By Hiroi Tomioka, Junichi Masuda, Akikazu Takada and Akira Iwanami


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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