Open access peer-reviewed Edited Volume

Hyperbaric Oxygen Treatment in Research and Clinical Practice

Mechanisms of Action in Focus

Edited by Ines Drenjančević

University of Osijek, Croatia

Hyperbaric oxygen treatment (HBO2) is a widely accepted adjuvant therapy in various health conditions that exhibit impaired tissue blood flow. At high pressures, the delivery of the dissolved oxygen in plasma is enhanced, which contributes to better tissue oxygenation, cellular metabolism and ultimately, healing. However, this is not the only beneficial outcome of HBO2 treatment since oxygen is a highly reactive molecule and can induce upregulation of many enzymatic systems in the cell at the cellular, genetic and molecular level. Particularly, vascular/endothelial function is affected by the HBO2. Our understanding of these mechanisms is still emerging. There have been many controversies related to the HBO2 protocols and indications. As well as exhibiting beneficiary effects on the tissue perfusion, it is known that HBO2 demonstrates high toxicity at higher pressures, due to increased oxidative stress and barotrauma. On the other hand, there is a lack of translation of the knowledge on the mechanisms of action of HBO2 obtained from the experimental research to the clinical practice. Thus, this book presents the reader with an overview of the current knowledge on the mechanisms of HBO2 effects in various experimental models and clinical treatment protocols, in an attempt to provide a better understanding of how and when HBO2 should be used as an effective therapy without unwanted side effects.

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Hyperbaric Oxygen Treatment in Research and Clinical PracticeMechanisms of Action in FocusEdited by Ines Drenjančević

Published: August 29th 2018

DOI: 10.5772/intechopen.70322

ISBN: 978-1-78923-599-9

Print ISBN: 978-1-78923-598-2

eBook (PDF) ISBN: 978-1-83881-469-4

Copyright year: 2018

Books open for chapter submissions

4720 Total Chapter Downloads

1 Crossref Citations

2 Web of Science Citations

4 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Hyperbaric Oxygen Treatment: Old Treatment with New Understanding

By Ines Drenjančević


Open access peer-reviewed

2. Therapeutic Mechanisms of Action for Hyperbaric Oxygen on Femoral Head Necrosis

By Gerardo Bosco, Alex Rizzato, Giuliano Vezzani, Vincenzo Zanon and Enrico Camporesi


Open access peer-reviewed

3. Hyperbaric Oxygen Therapy in Traumatic Brain Injury: Cellular and Molecular Mechanisms

By Sanja Pekovic, Sanja Dacic, Danijela Krstic, Rada Jeremic, Marina Djelic and Predrag Brkic


Open access peer-reviewed

4. Microcirculation and Hyperbaric Oxygen Treatment

By Fethi Gul, Omer Faruk Boran and Reyhan Arslantas


Open access peer-reviewed

5. Cell Culture Effects of Altered Oxygen Levels and Hyperbaric Treatment In Vitro

By Edit Gara


Open access peer-reviewed

6. Mechanisms of HBO-Induced Vascular Functional Changes in Diabetic Animal Models

By Ivana Jukic, Mihael Mišir, Martina Mihalj, Zrinka Mihaljevic, Sanela Unfirer, Dijana Kibel and Aleksandar Kibel


Open access peer-reviewed

7. Toxic Effects of Hyperbaric Conditions

By Ali Erdal Gunes


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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