Open access peer-reviewed Edited Volume

Exploring New Findings on Amyloidosis

Amyloid protein aggregates are involved in ''protein-misfolding diseases'' of enormous social and economic impact, still with no effective therapies. The most prevalent amyloid pathologies are related to neurodegenerative diseases, but amyloidosis also affects other organs. The majority of the studies includes serious health connotations on amyloids. However, not all amyloid fibers play a detrimental role in host. An increasing number of studies shows an important beneficial role as ''functional amyloids''. This book opens an exciting door to provide up-to-date information about the function and the mechanisms of the amyloid formation process from the structural, biophysical, biomedical, and nanotechnological perspective, combining the new findings on toxic and functional amyloids studies using theoretical and experimental approaches to fight against amyloid-based diseases.

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Exploring New Findings on AmyloidosisEdited by Ana Maria Fernandez-Escamilla

Published: August 24th 2016

DOI: 10.5772/61496

ISBN: 978-953-51-2619-5

Print ISBN: 978-953-51-2618-8

eBook (PDF) ISBN: 978-953-51-5447-1

Copyright year: 2016

Books open for chapter submissions

10900 Total Chapter Downloads

5 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Modulating Role of TTR in Aβ Toxicity, from Health to Disease

By Isabel Cardoso, Luis Miguel Santos and Mobina Alemi

878

Open access peer-reviewed

2. Supramolecular Organization of Amyloid Fibrils

By Dmitry Kurouski

879

Open access peer-reviewed

3. Advances in AFM Imaging Applications for Characterizing the Biophysical Properties of Amyloid Fibrils

By Wonseok Lee, Hyungbeen Lee, Gyudo Lee and Dae Sung Yoon

1173

Open access peer-reviewed

4. Effects of Amyloid-β Deposition on Mitochondrial Complex I Activity in Brain: A PET Study in Monkeys

By Hideo Tsukada

755

Open access peer-reviewed

5. Kinetics of Amyloid Formation by Different Proteins and Peptides: Polymorphism and Sizes of Folding Nuclei of Fibrils

By Oxana V. Galzitskaya, Nikita V. Dovidchenko and Olga M. Selivanova

704

Open access peer-reviewed

6. Role of Glycation in Amyloid: Effect on the Aggregation Process and Cytotoxicity

By Clara Iannuzzi, Gaetano Irace and Ivana Sirangelo

939

Open access peer-reviewed

7. Is Alzheimer's Associated Amyloid Beta an Innate Immune Protein

By Ruth Kandel, Mitchell R White, I-Ni Hseih and Kevan L. Hartshorn

906

Open access peer-reviewed

8. Amyloidogenesis and Responses to Stress

By Magda de Eguileor, Rossana Girardello, Annalisa Grimaldi, Laura Pulze and Gianluca Tettamanti

612

Open access peer-reviewed

9. Developments in the Treatment of Amyloid A Amyloidosis Secondary to Rheumatoid Arthritis

By Tadashi Nakamura

589

Open access peer-reviewed

10. The Role of Human IAPP in Stress and Inflammatory Processes in Type 2 Diabetes

By Joel Montane and Anna Novials

877

Open access peer-reviewed

11. Proteasome Inhibitors to Treat AL Amyloidosis

By James J. Driscoll and Saulius Girnius

971

Open access peer-reviewed

12. Amyloid Nephropathy: A Practical Diagnostic Approach and Review on Pathogenesis

By Paisit Paueksakon

725

Open access peer-reviewed

13. A Nanobody‐Based Approach to Amyloid Diseases, the Gelsolin Case Study

By Adriaan Verhelle and Jan Gettemans

894

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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