Open access peer-reviewed Edited Volume

Liquid Biopsy

Edited by Ilze Strumfa

Riga Stradiņš University


Reliable diagnosis is the cornerstone, starting point, and prerequisite of successful treatment. Therefore, development of innovative diagnostic technologies represents a hot topic in medical research. Liquid biopsy is a novel, minimally invasive laboratory evaluation concept for diagnostic, prognostic, and predictive testing, as well as dynamic monitoring of treatment or disease course. To achieve these goals, a multitude of specific, targeted tests can be performed to detect free nucleic acids, exosomes, microRNAs, tumor-educated platelets, and whole cells of tumor or fetal origin in different biological fluids, including blood, urine, cerebrospinal fluid, and others. Although tissue biopsy has long been considered the gold standard of diagnostics, especially regarding malignant tumors, liquid biopsy has the advantages of a non-invasive approach and thus low risk of complications. It is technically feasible even in serious general status or if tumors or metastases are not easily accessible using conventional tissue biopsy. The testing is fast, exact, and can be repeated to ensure real-time follow-up. In contrast to classic tumor markers, liquid biopsy is distinguished by high specificity at genomic, proteomic, and cellular levels. It is expected to equal and exceed the diagnostic value of tissue biopsy. The field of liquid biopsies is developing rapidly regarding the selection of targets, technological improvements, and quality assessment. This book, written by a global team of recognized scientists, comprises state-of-the-art reviews on the current knowledge and advances in the technologies and software for liquid biopsy. Examples of practical application of liquid biopsy to evaluate thyroid cancer, multiple myeloma, etc. are discussed as well. The book is intended to serve as a reference for scientists and clinicians interested in the development and practical implementation of liquid biopsy.

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Liquid BiopsyEdited by Ilze Strumfa

Published: July 10th 2019

DOI: 10.5772/intechopen.73612

ISBN: 978-1-83881-130-3

Print ISBN: 978-1-83881-129-7

eBook (PDF) ISBN: 978-1-83881-131-0

Copyright year: 2019

Books open for chapter submissions

7494 Total Chapter Downloads

6 Crossref Citations

4 Web of Science Citations

11 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Liquid Biopsy — A Promising Technology of the Future

By Ilze Strumfa and Janis Gardovskis


Open access peer-reviewed

2. Profiling Circulating Tumour Cells for Clinical Applications

By Kah Yee Goh and Wan-Teck Lim


Open access peer-reviewed

3. Circulating Cell-Free DNA

By Yingli Sun, Ke An and Caiyun Yang


Open access peer-reviewed

4. A Review on Machine Learning and Deep Learning Techniques Applied to Liquid Biopsy

By Arets Paeglis, Boriss Strumfs, Dzeina Mezale and Ilze Fridrihsone


Open access peer-reviewed

5. Liquid Biopsies in Multiple Myeloma

By David Vrabel, Adela Souckova, Lenka Sedlarikova and Sabina Sevcikova


Open access peer-reviewed

6. Liquid Biopsy in Patients with Thyroid Carcinoma

By Ilze Fridrihsone, Arnis Abolins, Andrejs Vanags, Dzeina Mezale and Guntis Bahs


Open access peer-reviewed

7. The Diagnostic and Prognostic Application of Heat Shock Proteins and their Post-Translational Modifications from Liquid Biopsies

By Byron Baron


Open access peer-reviewed

8. Blood-Brain Barrier Breakdown by Combined Detection of Circulating Tumor and Endothelial Cells in Liquid Biopsy

By Natalia Malara and Giuseppe Donato


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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