Open access peer-reviewed Edited Volume

Leishmaniases as Re-emerging Diseases

Edited by Farhat Afrin

Taibah University, Saudi Arabia


Hassan Hemeg

Taibah University

Leishmania parasites plague the mammalian host causing high morbidity and mortality. The parasites persist in the hostile milieu, crippling its defensive arsenal. In the face of mounting resistance to an antiquated drug arsenal, new approaches are urgently desired to keep the infection at bay. Furthermore, to strengthen the leishmaniasis elimination drive, particular emphasis has to be laid on identification of new targets and vaccination strategies. This book gives a brief glimpse of the epidemiology of leishmaniasis, immune evasion, vaccination, and therapeutic modalities that may work by untangling the immunological cross-wires of pathogenic cross-talk. The Conventional treatment and its drawbacks, the prospects of phytotherapy and nanomedicines, are also discussed. The identification of drug targets with the aim of designing inhibitors is also exemplified.

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Leishmaniases as Re-emerging DiseasesEdited by Farhat Afrin

Published: October 10th 2018

DOI: 10.5772/intechopen.71150

ISBN: 978-1-78984-102-2

Print ISBN: 978-1-78984-101-5

eBook (PDF) ISBN: 978-1-83881-521-9

Copyright year: 2018

Books open for chapter submissions

11127 Total Chapter Downloads

17 Crossref Citations

9 Web of Science Citations

34 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Leishmaniasis: An Emerging Clinical Syndrome

By Farhat Afrin and Hassan A. Hemeg


Open access peer-reviewed

2. Visceral Leishmaniasis

By Sujit K. Bhattacharya, Ajanta Ghosal, Sudeshna Ganguly, Sandipan Ganguly, Sabahat Azim and Shanta Dutta


Open access peer-reviewed

3. Leishmaniases in West Africa: Past and Current

By Abdoulaye Kassoum Kone, Mahamadou A. Thera, Babacar Faye and Ogobara K. Doumbo†


Open access peer-reviewed

4. Immune Evasion Strategies

By M. Magdalena Aguirre-Garcia, Alma R. Escalona-Montaño, Arturo A. Wilkins-Rodríguez and Laila Gutiérrez-Kobeh


Open access peer-reviewed

5. Vaccines for Human Leishmaniasis: Where Do We Stand and What Is Still Missing?

By Pedro Cecílio, Fabiano Oliveira and Anabela Cordeiro da Silva


Open access peer-reviewed

6. Vaccines for Visceral Leishmaniasis: Hopes and Hurdles

By Eltahir Awad Gasim Khalil


Open access peer-reviewed

7. The Polyamine Pathway as a Potential Target for Leishmaniases Chemotherapy

By Juliana Ide Aoki, Sandra Marcia Muxel, Juliane Cristina Ribeiro Fernandes and Lucile Maria Floeter-Winter


Open access peer-reviewed

8. 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGR) Enzyme of the Sterol Biosynthetic Pathway: A Potential Target against Visceral Leishmaniasis

By Sushma Singh and N. Kishore Babu


Open access peer-reviewed

9. Alternative Treatment for Leishmaniasis

By Renata Mondêgo de Oliveira, Solange de Araújo Melo, Tatiane Aranha da Penha-Silva, Fernando Almeida-Souza and Ana Lucia Abreu-Silva


Open access peer-reviewed

10. Natural Compounds and Extracts from Mexican Medicinal Plants with Anti-Leishmanial Activity: An Update

By María Adelina Jiménez-Arellanes and Rosalba León-Díaz


Open access peer-reviewed

11. Nanomedicines for Cutaneous Leishmaniasis

By Ariane Sousa-Batista and Bartira Rossi-Bergmann


Open access peer-reviewed

12. Crossing Biological Barriers for Leishmaniasis Therapy: From Nanomedicinal Targeting Perspective

By Gul Shahnaz, Hafiz Shoaib Sarwar and Masoom Yasinzai


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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