Open access peer-reviewed Edited Volume

New Research Directions in DNA Repair

Edited by Clark Chen

University of California, San Diego, United States of America

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

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New Research Directions in DNA RepairEdited by Clark Chen

Published: May 22nd 2013

DOI: 10.5772/46014

ISBN: 978-953-51-1114-6

eBook (PDF) ISBN: 978-953-51-5375-7

Copyright year: 2013

Books open for chapter submissions

53876 Total Chapter Downloads

52 Crossref Citations

79 Web of Science Citations

114 Dimensions Citations


Open access peer-reviewed

1. Recombination Hot-Spots and Defense Players – Maintenance of Genomic Integrity

By Radhika Pankaj Kamdar and Basuthkar J. Rao


Open access peer-reviewed

2. The Role of Multimerization During Non-Homologous End Joining

By Michelle Rubin, Jonathan Newsome and Albert Ribes-Zamora


Open access peer-reviewed

3. Epimutation in DNA Mismatch Repair (MMR) Genes

By Kouji Banno, Iori Kisu, Megumi Yanokura, Yuya Nogami, Kiyoko Umene, Kosuke Tsuji, Kenta Masuda, Arisa Ueki, Nobuyuki Susumu and Daisuke Aoki


Open access peer-reviewed

4. Evolving DNA Repair Polymerases: From Double—Strand Break Repair to Base Excision Repair and VDJ Recombination

By Maria Jose Martin and Luis Blanco


Open access peer-reviewed

5. Direct Repair in Mammalian Cells

By Stephanie L. Nay and Timothy R. O‘Connor


Open access peer-reviewed

6. Chromatin Remodeling in Nucleotide Excision Repair in Mammalian Cells

By Wilner Martínez-López, Leticia Méndez-Acuña, Verónica Bervejillo, Jonatan Valencia-Payan and Dayana Moreno-Ortega


Open access peer-reviewed

7. Emerging Features of DNA Double-Strand Break Repair in Humans

By Hyun Suk Kim, Robert Hromas and Suk-Hee Lee


Open access peer-reviewed

8. Regulation of DNA Repair Process by the Pro-Inflammatory NF-κB Pathway

By Simarna Kaur, Thierry Oddos, Samantha Tucker-Samaras and Michael D. Southall


Open access peer-reviewed

9. Relation of the Types of DNA Damage to Replication Stress and the Induction of Premature Chromosome Condensation

By Dorota Rybaczek and Magdalena Kowalewicz-Kulbat


Open access peer-reviewed

10. p21CDKN1A and DNA Repair Systems: Recent Findings and Future Perspectives

By Micol Tillhon, Ornella Cazzalini, Ilaria Dutto, Lucia A. Stivala and Ennio Prosperi


Open access peer-reviewed

11. The Role of P53 Exonuclease in Accuracy of DNA Synthesis and Sensitivity to Nucleoside Analogs in Various Compartments of Cells

By Galia Rahav and Mary Bakhanashvili


Open access peer-reviewed

12. Biological Systems that Control Transcription of DNA Repair and Telomere Maintenance-Associated Genes

By Fumiaki Uchiumi, Steven Larsen and Sei-ichi Tanuma


Open access peer-reviewed

13. The Endothelin Axis in DNA Damage and Repair: The Cancer Paradigm

By Panagiotis J. Vlachostergios and Christos N. Papandreou


Open access peer-reviewed

14. DNA Repair and Telomeres — An Intriguing Relationship

By Effrossyni Boutou, Dimitris Vlachodimitropoulos, Vassiliki Pappa, Horst-Werner Stürzbecher and Constantinos E. Vorgias


Open access peer-reviewed

15. Genetic Polymorphisms of DNA Repair Genes and DNA Repair Capacity Related to Aflatoxin B1 (AFB1)-Induced DNA Damages

By Qiang Xia, Xiao-Ying Huang, Feng Xue, Jian-Jun Zhang, Bo Zhai, De- Chun Kong, Chao Wang, Zhao-Quan Huang and Xi-Dai Long


Open access peer-reviewed

16. DNA Damage, DNA Repair and Cancer

By Carol Bernstein, Anil R. Prasad, Valentine Nfonsam and Harris Bernstein


Open access peer-reviewed

17. New Potential Therapeutic Approaches by Targeting Rad51- Dependent Homologous Recombination

By Axelle Renodon-Cornière, Pierre Weigel, Magali Le Breton and Fabrice Fleury


Open access peer-reviewed

18. DNA Repair and Resistance to Cancer Therapy

By António S. Rodrigues, Bruno Costa Gomes, Célia Martins, Marta Gromicho, Nuno G. Oliveira, Patrícia S. Guerreiro and José Rueff


Open access peer-reviewed

19. DNA Base Excision Repair: Evolving Biomarkers for Personalized Therapies in Cancer

By Vivek Mohan and Srinivasan Madhusudan


Open access peer-reviewed

20. Nucleotide Excision Repair Inhibitors: Still a Long Way to Go

By K. Barakat and J. Tuszynski


Open access peer-reviewed

21. The Molecular Epidemiology of DNA Repair Polymorphisms in Carcinogenesis

By Paul W. Brandt-Rauf, Yongliang Li, Changmin Long and Regina Monaco


Open access peer-reviewed

22. Aspects of DNA Damage from Internal Radionuclides

By Christopher Busby


Open access peer-reviewed

23. Radiosensitization Strategies Through Modification of DNA Double-Strand Break Repair

By Yoshihisa Matsumoto, Shoji Imamichi, Mikoto Fukuchi, Sicheng Liu, Wanotayan Rujira, Shingo Kuniyoshi, Kazuki Yoshida, Yasuhiro Mae and Mukesh Kumar Sharma


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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