Open access peer-reviewed Edited Volume

Frontiers in Radiation Oncology

Edited by Tejinder Kataria

Medanta The Medicity, India

The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research.

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Frontiers in Radiation OncologyEdited by Tejinder Kataria

Published: July 3rd 2013

DOI: 10.5772/3065

ISBN: 978-953-51-1163-4

eBook (PDF) ISBN: 978-953-51-7170-6

Copyright year: 2013

Books open for chapter submissions

23839 Total Chapter Downloads

3 Crossref Citations

4 Web of Science Citations

6 Dimensions Citations


Open access peer-reviewed

1. Histone Acetyltransferases (HATs) Involved in Non-Homologous End Joining as a Target for Radiosensitization

By Takahiro Oike, Hideaki Ogiwara, Takashi Nakano and Takashi Kohno


Open access peer-reviewed

2. A Framework for Modeling the Cellular Defending Mechanisms Against Genome Stress Under Radiotherapy

By Jin-Peng Qi, Yong-Sheng Ding and Xian-Hui Zeng


Open access peer-reviewed

3. Applications to Radiotherapy Using Three Different Dosimetric Tools: MAGIC-f Gel, PENELOPE Simulation Code and Treatment Planning System

By Thatiane Alves Pianoschi and Mirko Salomón Alva-Sánchez


Open access peer-reviewed

4. 3D Dosimetric Tools in Radiotherapy for Photon Beams

By Mirko Salomón Alva-Sánchez and Thatiane Alves Pianoschi


Open access peer-reviewed

5. A Respiratory Motion Prediction Based on Time-Variant Seasonal Autoregressive Model for Real-Time Image-Guided Radiotherapy

By Kei Ichiji, Noriyasu Homma, Masao Sakai, Makoto Abe, Norihiro Sugita and Makoto Yoshizawa


Open access peer-reviewed

6. Neutron Dose Equivalent in Tissue Due to Linacs of Clinical Use

By S. Agustín Martínez Ovalle


Open access peer-reviewed

7. Curative Radiotherapy in Metastatic Disease: How to Develop the Role of Radiotherapy from Local to Metastases

By Chul-Seung Kay and Young-Nam Kang


Open access peer-reviewed

8. Locally Advanced Esophageal Cancer

By Hend Ahmed El-Hadaad and Hanan Ahmed Wahba


Open access peer-reviewed

9. Reduction Mammaplasty and Intra-Operative Radiotherapy (IORT) in Conservative Surgery

By Simonetta Franchelli, Paolo Meszaros, Michela Massa, Marina Guenzi, Renzo Corvò, Davide Pertile, Giorgia Timon, Ferdinando Cafiero and Pierluigi Santi


Open access peer-reviewed

10. Effects of Radiotherapy on Pharyngeal Reconstruction After Pharyngo-Laryngectomy

By Jimmy Yu-Wai Chan and Gregory Ian Siu Kee Lau


Open access peer-reviewed

11. Breast Cancer Post Treatment Quality of Life

By Sabina Saric


Open access peer-reviewed

12. Nutrition Intervention Improves Nutritional Status and Quality of Life Outcomes in Patients Undergoing Radiotherapy

By Elisabeth Isenring


Edited Volume and chapters are indexed in

  • Worldcat
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  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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