Open access peer-reviewed Edited Volume

Proton Therapy

Current Status and Future Directions

Edited by Thomas J. FitzGerald

UMass Memorial Medical Center


Maryann Bishop-Jodoin

University of Massachusetts Medical School

Over the past twenty-five years, proton therapy has become more prominent worldwide. It is an important component of clinical radiation therapy for both adult and pediatric clinical care. Due to the inherent ability of protons to spare normal tissue, protons will continue to develop and become increasingly important in radiation oncology. As such, Proton Therapy - Current Status and Future Directions reviews many aspects of proton care including the application of protons in modern clinical trials. It also reviews problems associated with the migration of proton care worldwide and examines the future direction of proton care. This project was created by colleagues at IntechOpen and was carefully managed by Romina Rovan. It has been a privilege to help coordinate the text and chapters designed to acknowledge the history, footprint, and growing interest of proton care worldwide. Proton management is now embedded in the clinical trials process. In pediatric care, proton delivery is embedded with photons for the management of pediatric malignancies and adult groups have initiated proton-specific clinical trials. A proton registry has been established and outcomes are under evaluation. Due to the inherent ability of protons to spare normal tissue, protons will continue to develop and become increasingly important in radiation oncology.

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Proton TherapyCurrent Status and Future DirectionsEdited by Thomas J. FitzGerald

Published: August 18th 2021

DOI: 10.5772/intechopen.91072

ISBN: 978-1-83968-013-7

Print ISBN: 978-1-83968-012-0

eBook (PDF) ISBN: 978-1-83968-017-5

Copyright year: 2021

Books open for chapter submissions

763 Total Chapter Downloads


Open access peer-reviewed

1. History and Overview of Proton Therapy

By Ameer L. Elaimy, Linda Ding, Carla Bradford, Yansong Geng, Harry Bushe, I-Lin Kuo, Yankhua Fan, Fenhong Liu, Abdulnasser Khalifeh, Suhong Yu, Jonathan Saleeby, James Shen, Kevin O’Connor and Kenneth Ulin


Open access peer-reviewed

2. Proton Therapy Center Layout and Interface

By Ameer L. Elaimy, Linda Ding, Jonathan Glanzman, Lakshmi Shanmugham, Beth Herrick, Jody Morr, Dan Han, Jeffrey C. Buchsbaum and Thomas J. FitzGerald


Open access peer-reviewed

3. Multi-Institutional Data Collection and Analysis via the Pediatric Proton/Photon Consortium Registry

By Nicholas J. DeNunzio, Miranda P. Lawell and Torunn I. Yock


Open access peer-reviewed

4. Credentialing Proton Centers for Clinical Trials

By Paige A. Taylor


Open access peer-reviewed

5. Clinical Trials Evaluating Proton Therapy

By Paige A. Taylor


Open access peer-reviewed

6. Adaptive Proton Therapy in Head and Neck Cancer

By Nagarjuna Burela


Open access peer-reviewed

7. Proton Therapy in Lower-Middle-Income Countries: From Facts and Reality to Desire, Challenges and Limitations

By Sandra Ileana Pérez Álvarez, Francisco Javier Lozano Ruiz, Federico Maldonado Magos and Aida Mota García


Open access peer-reviewed

8. Proton Cancer Therapy: Synchrotron-Based Clinical Experiences 2020 Update

By Felipe Angel Calvo Manuel, Elena Panizo, Santiago M. Martin, Javier Serrano, Mauricio Cambeiro, Diego Azcona, Daniel Zucca, Borja Aguilar, Alvaro Lassaletta and Javier Aristu


Open access peer-reviewed

9. The Future of Proton Therapy

By Thomas J. FitzGerald, Linda Ding, Christopher Riberdy, Jack Bailey, Michael Anderegg, Ameer Elaimy, James Shen, Kevin O’Connor, Carla Bradford, I-Lin Kuo, Yankhua Fan, Fenghong Liu, Suhong Yu, Harry Bushe, Jonathan Saleeby, Paul Rava, Shirin Sioshansi, M. Giulia Cicchetti, Janaki Moni, Eric Ko, Allison Sacher, Daniel Han and Maryann Bishop-Jodoin


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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