About the book
The word senescence is derived from the Latin word “senex“ (meaning old man). In biology, senescence is a process by which a cell ages and permanently stops dividing. Senescence can be induced by several stimuli including cellular stress, DNA damage, telomere shortening, and oncogene activation. Senescence is the process of growing old (aging). Aging is a natural universal phenomenon affecting all living organisms (e.g., plants, animals, and humans). It is a progressive deterioration of the cell and organ functioning due to damage accumulation over time. The underlying mechanisms of aging at the cellular level are not fully understood. The most popular theory is the free-radical theory. The lifespan of living organisms ranges from few hours (animals) to few thousand years (plants). The maximum theoretical lifespan in humans is around 120 years. Aging and lifespan are influenced by multiple factors including genetic, epigenetic, lifestyle, environmental, metabolic, and endocrine factors. Extending lifespan while keeping health and vitality has always been a dream for mankind. The “successful aging” is aging without any disabilities and severe diseases. Senescence plays a role in the development of several age-related chronic diseases (e.g., ischemic heart disease, stroke, and cancer). Senescence is emerging as a therapeutic target for several diseases. Clinical trials using pro-senescent and anti-senescent therapies are in progress.
This book intends to provide the reader with a comprehensive overview of the current knowledge about mechanisms and management of senescence in humans together with comparative data in animals and plants.