Open access peer-reviewed Edited Volume


Hassan M. Heshmati

Endocrinology Metabolism Consulting, LLC

A clinical researcher in Endocrinology and Metabolism with 44 years of experience in Academia and Pharmaceutical Companies and 269 presentations and publications.


Aging Cellular Stress DNA Damage Telomere Shortening Oncogene Activation Longevity Ischemic Heart Disease Stroke Cancer Senotherapy Pro-senescent Therapy Anti-Senescent Therapy

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About the book

The word senescence is derived from the Latin word “senex“ (meaning old man). In biology, senescence is a process by which a cell ages and permanently stops dividing. Senescence can be induced by several stimuli including cellular stress, DNA damage, telomere shortening, and oncogene activation. Senescence is the process of growing old (aging). Aging is a natural universal phenomenon affecting all living organisms (e.g., plants, animals, and humans). It is a progressive deterioration of the cell and organ functioning due to damage accumulation over time. The underlying mechanisms of aging at the cellular level are not fully understood. The most popular theory is the free-radical theory. The lifespan of living organisms ranges from few hours (animals) to few thousand years (plants). The maximum theoretical lifespan in humans is around 120 years. Aging and lifespan are influenced by multiple factors including genetic, epigenetic, lifestyle, environmental, metabolic, and endocrine factors. Extending lifespan while keeping health and vitality has always been a dream for mankind. The “successful aging” is aging without any disabilities and severe diseases. Senescence plays a role in the development of several age-related chronic diseases (e.g., ischemic heart disease, stroke, and cancer). Senescence is emerging as a therapeutic target for several diseases. Clinical trials using pro-senescent and anti-senescent therapies are in progress.

This book intends to provide the reader with a comprehensive overview of the current knowledge about mechanisms and management of senescence in humans together with comparative data in animals and plants.

Publishing process

Book initiated and editor appointed

Date completed: April 30th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: May 28th 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: July 27th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: October 15th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: December 14th 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Hassan M. Heshmati

Endocrinology Metabolism Consulting, LLC

Hassan M. Heshmati, Medical Doctor, Endocrinologist, has 45 years of experience in clinical research in Academia (university-affiliated hospitals in Paris, France and Mayo foundation in Rochester, MN, USA) and in Pharmaceutical Companies (Sanofi, Essentialis, and Gelesis, USA). His research activity has been related to pituitary tumor, hyperthyroidism, thyroid cancer, osteoporosis, obesity, and diabetes. He has extensive knowledge in the development of anti-obesity products. He is the author of 275 presentations and publications related to Endocrinology and Metabolism. He is currently Consultant at Endocrinology Metabolism Consulting, LLC, Anthem, AZ, USA.

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Book chapters authored 5

Books edited 0

Introducing your Author Service Manager

Ms. Dolores Kuzelj

As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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